@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_0644: (2015-12-17 )
MQHKTIMDKIIIQGARENNLKNIFLEIPKNQFVVFTGLSGSGKSTLAFDTLYAEGQRRYLESLSSYARQFLDKVGKPNVDKIEGLTPAIAIDQKTTSKNPRSTVGTITEIYDYLRLLFARVGEQFCPTCLEPISSMSASDIISQICHLEENSKIIILAPIIKDKKGSFNDKLESLRLKGYVRAFVDGVMVRLDEEIHLHKTKKHTIEAVVDRVVINSENASRIASAVEKALKESYGELEVEILQDNAPSIRKHYSEHKACFKCKMSFEELEPLSFSFNSPKGACESCLGLGTKFSLDISKILDPNTPLNQGAIKVIFGYNRSYYAQMFEGFCTYNGIDSALCFNELNKEQQDALLYGNGTEISFHFKNSPLKRPWKGIIQIAYDMFKEQKDLSDYMSEKTCSSCNGHRLKASSLSVQVAGLKMADFLTKPIEEVYHFFNDPTHFNYLNEQEKKIAEPILKEILERVFFLYDVGLGYLTLGRDARTISGGESQRIRIASQIGSGLTGVLYVLDEPSIGLHEKDTLKLINTLRNLQKKGNTLIVVEHDKETIKHADFVVDIGPKAGRHGGEVVFSGSVKDLLQNNHSTALYLNGTKKIERPKFEPPKEKHFLEIKNVNINNIKNLSVQIPLKQLVCITGVSGSGKSSLILQTLLPTAQTLLNHAKKNQSLNGVEIVGLEYLDKVIYLDQAPIGKTPRSNPATYTGVMDEIRILFAEQKEAKILGYSTSRFSFNVKGGRCEKCQGDGDIKIEMHFLPDVLVQCDSCKGAKYNPQTLEIKVKGKSIADVLNMSVEEAYEFFAKFPKIAVKLKTLIDVGLGYITLGQNATTLSGGEAQRIKLAKELSKKDTGKTLYILDEPTTGLHFEDVNHLLQVLHSLVALGNSMLVIEHNLDIIKNADYIIDMGPDGGDKGGKVIASGTPLEVAQNCEKTQSYTGKFLALELK
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.-......270.......280.......290....-...300-.......--310.....-..320.......330.......340.......350.......360.-....-----------..---.-----370...---....--------380.------------------....----------.------.390.......400.......410.......420.......430....--------...------440.....-..450...-..----..460.......470.......480.......490.......500...-....510.......520.......530.......540.......550.-.......560.......570.......580.---..-....590---...--------..--.-------.---.--600--....-...610...----.----.----..620.......630.......640.......650---------.......660....------...670....--....-680.......690.......700.......710.......720.........730.......740.......-750-----------------------------------------------------------------------------------...----------------------------.....760.......770.......780.......790.......800------------------------.........810.......820.......830.......840.......850.......860.......870.....-..880.......890-.-......900.......910.......920......-.930.......940
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MQ
H
K
T
I
M
D
K
I
I
IQGARENNL
K
N
I
F
L
EIPKN
Q
F
V
V
F
TGLSGSGK
S
T
L
A
F
D
T
L
Y
A
E
G
Q
R
R
Y
L
E
S
L
S
S
Y
A
R
Q
F
L
D
KVGKPNV
D
K
IEGLT
P
A
I
A
IDQKTTSKNPRSTVG
T
I
T
E
I
Y
D
Y
L
R
L
L
F
A
R
V
G
E
Q
F
C
P
T
C
L
E
P
I
S
SM
S
A
S
D
I
I
S
Q
I
CHLEEN
S
K
I
I
I
L
A
PIIKDKKGS
F
N
D
K
L
E
S
L
R
L
K
G
Y
V
R
A
F
V
D
G
V
M
V
RLDE
E
I
H
LHKTKK
H
T
I
E
A
V
V
D
R
V
V
INSE
N
A
S
R
I
A
S
A
V
E
K
A
L
K
E
SYG
E
L
E
V
E
I
LQDN
A
P
S
I
R
K
H
Y
S
E
H
K
A
C
F
K
C-KM
S
F
E
ELE
P
L
S
F
SFNSP
K
G
A
C
E
S
C
L
GLG
T
K
F
S
L
-
D
I
S
K
IL-DPNTPLN--QG
A
I
K
V
I
F
-GY
N
R
S
Y
Y
A
Q
M
F
E
G
F
CTYNGI
D
S
A
L
C
F
N
E
LN
K
E
Q
Q
D
A
L
L
YGNG
T
E
-
I
-
S
F
H
F-----------KN---S-----PLK
R
P
W
---
K
G
I
I
--------
Q
I
A
Y
------------------
D
M
F
K
----------
E
------
Q
K
D
L
S
D
Y
M
S
EKTCSSCNG
H
R
L
KAS
S
L
S
V
Q
V
AG
L
K
M
A
D
F
L
T
K
P
I
E
E
V
Y
H
--------
F
FN------DPTHF
N
Y
L
-
N
E
Q
E
K
K
I
A
-
E
P
----
I
L
K
E
I
L
E
R
V
F
F
L
Y
DVGLG
Y
L
T
LGRDARTISGGES
Q
R
I
R
I
A
S
Q
IGSGL
T
-
G
V
L
Y
V
LDEPSIGLH
E
K
D
T
L
K
L
I
N
T
L
R
N
L
Q
KKG
N
T
L
I
V
V
EHD
K
E
TIK-H-A
D
F
V
V
DIGPKAGRHG
G
E
V
V
FSG
S
V
K
D
L
L
QNN---HS-
T
A
L
Y
LN----GTK--------KI--E-------R---P--KFE--PPKE-K
H
F
L
E
I
KNV----N----I----N
N
I
K
N
L
S
V
Q
IP
L
K
Q
L
V
C
I
TGVSGSG
K
S
S
L
I
L
Q
T
L
L
---------
P
T
A
Q
T
L
L
N
H
A
K
KNQ------SLNG-
V
E
I
V
G
--
L
E
Y
L
-
D
K
V
I
Y
LDQAPIGKTPRSNPATY
T
G
V
M
D
E
I
R
I
L
F
AEQKE
A
K
I
--
L
G
Y
ST
S
R
F
S
F
NVKGGRCEKCQGDG
D
I
K
I
E
-
M
H
------------------------------------------------------------------------------------FL
P
----------------------------
D
V
L
V
QCDSCKGAKYNP
Q
T
L
E
I
K
V
KG
K
S
I
A
D
V
L
N
M
S
V
E
E
A
Y
E
F
F
A
KF--------------------------
P
K
I
A
V
K
L
K
T
L
I
D
VGL
G
Y
I
T
LGQNATTLSGG
E
A
Q
R
I
K
L
A
K
E
L
SKKDTG
K
T
L
Y
I
L
DEPTTGL
H
F
E
D
V
N
H
L
L
Q
V
L
H
S
L
V
A-LG
N
S
M
L
V
I
EHNL
D
I
I-K-NA
D
Y
I
I
D
MGPDGGDKG
G
K
V
I
ASGT
P
L
E
V
A
Q
N
C
E
K
T
-
Q
SYTG
K
F
L
A
L
E
LK
1
PsiBlast_PDB
96.10
52%
-86
- C5 -
3UWX
3
?
A:
[21-952]
------
M
D
K
I
I
V
K
G
A
R
A
H
N
L
K
N
I
D
V
E
I
P
R
G
K
L
V
V
L
T
G
L
S
G
S
G
K
S
S
L
A
F
D
T
I
Y
A
E
G
Q
R
R
Y
V
E
S
L
S
A
Y
A
R
Q
F
L
G
Q
M
E
K
P
D
V
D
A
I
E
G
L
S
P
A
I
S
I
D
Q
K
T
T
S
R
N
P
R
S
T
V
G
T
V
T
E
I
Y
D
Y
L
R
L
L
F
A
R
I
G
R
P
I
C
P
T
H
G
I
E
I
Q
S
Q
T
I
E
Q
M
V
D
R
L
L
S
Y
P
E
R
T
K
M
Q
I
L
A
P
I
V
S
G
K
K
G
T
H
A
K
T
L
E
D
I
R
K
Q
G
Y
V
R
V
R
I
D
R
E
M
R
E
L
T
G
D
I
E
L
E
K
N
K
K
H
S
I
D
V
V
V
D
R
I
I
I
K
D
G
I
A
A
R
L
A
D
S
L
E
T
A
L
K
L
A
D
G
K
V
V
V
D
V
I
G
E
G
----
E
L
L
F
S
E
K
H
A
C
P
Y
C
-
G
F
S
I
G
E
L
E
P
R
L
F
S
F
N
S
P
F
G
A
C
P
D
C
D
G
L
G
A
K
L
E
V
-
D
L
D
L
V
I
--
P
N
D
E
L
T
LK
E
H
A
I
A
P
W
E
-
P
----
Y
Y
P
Q
L
L
E
A
V
C
R
H
Y
G
I
P
M
D
V
P
V
K
D
L
P
K
E
Q
L
D
K
I
L
Y
G
S
G
G
E
P
I
-
Y
F
R
Y
-----------
T
N
DF-
G
-----
Q
V
R
E
Q
Y
I
AF
E
G
V
I
P
N
V
E
R
R
Y
R
E
T
S
S
------------------
D
Y
I
R
----------
E
------
Q
--
M
E
K
Y
M
A
E
Q
P
C
P
T
C
Q
G
Y
R
L
K
K
E
S
L
A
V
L
V
G
G
K
H
I
G
E
V
T
A
M
S
V
T
E
A
L
A
--------
F
F
D
------
G
L
E
----
L
-
T
E
K
E
A
Q
I
A
-
R
L
----
I
L
R
E
I
R
D
R
L
G
F
L
Q
N
V
G
L
D
Y
L
T
L
S
R
S
A
G
T
L
S
G
G
E
A
Q
R
I
R
L
A
T
Q
I
G
S
R
L
T
-
G
V
L
Y
V
L
D
E
P
S
I
G
L
H
Q
R
D
N
D
R
L
I
A
T
L
K
S
M
R
D
L
G
N
T
L
I
V
V
E
H
D
E
D
T
M
L
-
A
-
A
D
Y
L
I
D
I
G
P
G
A
G
I
H
G
G
E
V
V
A
A
G
T
P
E
E
V
M
N
D
P
---
N
S
L
T
G
Q
Y
L
S
----
G
K
K
--------
F
I
--
P
-------
I
---
P
--
A
E
R
--
R
R
P
D
-
G
R
W
L
E
V
V
G
A
----
R
----
E
----
H
N
L
K
N
V
S
V
K
I
P
L
G
T
F
V
A
V
T
G
V
S
G
S
G
K
S
T
L
V
N
E
V
L
Y
---------
K
A
L
A
Q
K
L
H
R
A
K
A
K
P
------
G
E
H
--
R
D
I
R
G
--
L
E
H
L
-
D
K
V
I
D
I
D
Q
S
P
I
G
R
T
P
R
S
N
P
A
T
Y
T
G
V
F
D
D
I
R
D
V
F
A
S
T
N
E
A
K
V
--
R
G
Y
K
K
G
R
F
S
F
N
V
K
G
G
R
C
E
A
C
H
G
D
G
I
I
K
I
E
-
M
H
------------------------------------------------------------------------------------
F
L
P
----------------------------
D
V
Y
V
P
C
E
V
C
H
G
K
R
Y
N
R
E
T
L
E
V
T
Y
K
G
K
N
I
A
E
V
L
D
M
T
V
E
D
A
L
D
F
F
A
S
I
--------------------------
P
K
I
K
R
K
L
E
T
L
Y
D
V
G
L
G
Y
M
K
L
G
Q
P
A
T
T
L
S
G
G
E
A
Q
R
V
K
L
A
A
E
L
H
R
R
S
N
G
R
T
L
Y
I
L
D
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P
T
T
G
L
H
V
D
D
I
A
R
L
L
D
V
L
H
R
L
V
D
-
N
G
D
T
V
L
V
I
E
H
N
L
D
V
I
-
K
-
T
A
D
Y
I
I
D
L
G
P
E
G
G
D
R
G
G
Q
I
V
A
V
G
T
P
E
E
V
A
---
E
V
K
-
E
S
H
T
G
R
Y
L
K
P
I
L
E
133
HHSearch
96.04
53%
-88
- C3 -
2R6F
5
?
A:
[21-956]
------
M
D
K
I
I
V
K
G
A
R
A
H
N
L
K
N
I
D
V
E
I
P
R
G
K
L
V
V
L
T
G
L
S
G
S
G
K
S
S
L
A
F
D
T
I
Y
A
E
G
Q
R
R
Y
V
E
S
L
S
A
Y
A
R
Q
F
L
G
Q
M
E
K
P
D
V
D
A
I
E
G
L
S
P
A
I
S
I
D
Q
K
T
T
S
R
N
P
R
S
T
V
G
T
V
T
E
I
Y
D
Y
L
R
L
L
F
A
R
I
G
R
P
I
C
P
T
H
G
I
E
I
Q
S
Q
T
I
E
Q
M
V
D
R
L
L
S
Y
P
E
R
T
K
M
Q
I
L
A
P
----------------------------------------------
I
D
V
V
V
D
R
I
I
I
K
D
G
I
A
A
R
L
A
D
S
L
E
T
A
L
K
L
A
D
G
K
V
V
V
D
V
I
G
----
E
G
E
L
L
F
S
E
K
H
A
C
P
Y
C
-
G
F
S
I
G
E
L
E
P
R
L
F
S
F
N
S
P
F
G
A
C
P
D
C
D
G
L
G
A
K
L
E
V
-
D
L
D
L
V
I
P
N
D
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L
T
L
K
--
E
H
A
I
A
P
W
E
-
P
----
Y
Y
P
Q
L
L
E
A
V
C
R
H
Y
G
I
P
M
D
V
P
V
K
D
L
P
K
E
Q
L
D
K
I
L
Y
G
S
G
G
E
-
P
I
Y
F
R
Y
T
N
DF
G
------
Q
V
---
R
-----
E
Q
Y
I
A
F
---
E
G
V
I
--------
P
N
V
E
------------------
R
R
Y
R
----------
E
TSS
D
Y
I
R
E
Q
M
E
K
Y
M
A
E
Q
P
C
P
T
C
Q
G
Y
R
L
K
K
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S
L
A
V
L
V
G
G
K
H
I
G
E
V
T
A
M
S
V
T
E
A
L
A
--------
F
F
D
------
G
L
E
L
-----
T
E
K
E
A
Q
I
A
-
R
L
----
I
L
R
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I
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D
R
L
G
F
L
Q
N
V
G
L
D
Y
L
T
L
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A
G
T
L
S
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G
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A
Q
R
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R
L
A
T
Q
I
G
S
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L
T
-
G
V
L
Y
V
L
D
E
P
S
I
G
L
H
Q
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N
D
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L
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K
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M
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D
L
G
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L
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V
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D
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A
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A
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Y
L
I
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P
G
A
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H
G
G
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A
A
G
T
P
E
E
V
M
N
D
P
N--
S
L
-
T
G
Q
Y
L
S
----
G
K
K
--------
F
I
--
P
-------
I
---
P
--
A
E
R
--
R
R
P
D
-
G
R
W
L
E
V
V
G
A
----
R
----
E
----
H
N
L
K
N
V
S
V
K
I
P
L
G
T
F
V
A
V
T
G
V
S
G
S
G
K
S
T
L
V
N
E
V
L
Y
---------
K
A
L
A
Q
K
L
H
R
A
-
K
A
K
------
P
G
E
H
-
R
D
I
R
G
--
L
E
H
L
-
D
K
V
I
D
I
D
Q
S
P
I
G
R
T
P
R
S
N
P
A
T
Y
T
G
V
F
D
D
I
R
D
V
F
A
S
T
N
E
A
K
V
--
R
G
Y
K
K
G
R
F
S
F
N
V
K
G
G
R
C
E
A
C
H
G
D
G
I
I
K
I
E
-
M
H
------------------------------------------------------------------------------------
F
L
P
----------------------------
D
V
Y
V
P
C
E
V
C
H
G
K
R
Y
N
R
E
T
L
E
V
T
Y
K
G
K
N
I
A
E
V
L
D
M
T
V
E
D
A
L
D
F
F
A
S
I
--------------------------
P
K
I
K
R
K
L
E
T
L
Y
D
V
G
L
G
Y
M
K
L
G
Q
P
A
T
T
L
S
G
G
E
A
Q
R
V
K
L
A
A
E
L
H
R
R
S
N
G
R
T
L
Y
I
L
D
E
P
T
T
G
L
H
V
D
D
I
A
R
L
L
D
V
L
H
R
L
V
D
-
N
G
D
T
V
L
V
I
E
H
N
L
D
V
I
-
K
-
T
A
D
Y
I
I
D
L
G
P
E
G
G
D
R
G
G
Q
I
V
A
V
G
T
P
E
E
V
A
E
V
---
K
-
E
S
H
T
G
R
Y
L
K
P
I
L
E
2
PsiBlast_PDB
94.99
52%
-84
- C3 -
2R6F
5
?
A:
[22-952]
-------
D
K
I
I
V
K
G
A
R
A
H
N
L
K
N
I
D
V
E
I
P
R
G
K
L
V
V
L
T
G
L
S
G
S
G
K
S
S
L
A
F
D
T
I
Y
A
E
G
Q
R
R
Y
V
E
S
L
S
A
Y
A
R
Q
F
L
G
Q
M
E
K
P
D
V
D
A
I
E
G
L
S
P
A
I
S
I
D
Q
K
T
T
S
R
N
P
R
S
T
V
G
T
V
T
E
I
Y
D
Y
L
R
L
L
F
A
R
I
G
R
P
I
C
P
T
H
G
I
E
I
Q
S
Q
T
I
E
Q
M
V
D
R
L
L
S
Y
P
E
R
T
K
M
Q
I
L
A
P
----------------------------------------------
I
D
V
V
V
D
R
I
I
I
K
D
G
I
A
A
R
L
A
D
S
L
E
T
A
L
K
L
A
D
G
K
V
V
V
D
V
I
G
E
G
----
E
L
L
F
S
E
K
H
A
C
P
Y
C
-
G
F
S
I
G
E
L
E
P
R
L
F
S
F
N
S
P
F
G
A
C
P
D
C
D
G
L
G
A
K
L
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V
-
D
L
D
L
V
I
--
P
N
D
E
L
T
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E
H
A
I
A
P
W
E
-
P
----
Y
Y
P
Q
L
L
E
A
V
C
R
H
Y
G
I
P
M
D
V
P
V
K
D
L
P
K
E
Q
L
D
K
I
L
Y
G
S
G
G
E
P
I
-
Y
F
R
Y
-----------
T
N
DF-
G
-----
Q
V
R
E
Q
Y
I
AF
E
G
V
I
P
N
V
E
R
R
Y
R
E
T
S
S
------------------
D
Y
I
R
----------
E
------
Q
M
E
--
K
Y
M
A
E
Q
P
C
P
T
C
Q
G
Y
R
L
K
K
E
S
L
A
V
L
V
G
G
K
H
I
G
E
V
T
A
M
S
V
T
E
A
L
A
--------
F
F
D
------
G
L
E
----
L
-
T
E
K
E
A
Q
I
A
-
R
L
----
I
L
R
E
I
R
D
R
L
G
F
L
Q
N
V
G
L
D
Y
L
T
L
S
R
S
A
G
T
L
S
G
G
E
A
Q
R
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R
L
A
T
Q
I
G
S
R
L
T
-
G
V
L
Y
V
L
D
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P
S
I
G
L
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Q
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D
N
D
R
L
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A
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L
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M
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V
V
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L
-
A
-
A
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Y
L
I
D
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G
P
G
A
G
I
H
G
G
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V
V
A
A
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T
P
E
E
V
M
N
D
P
---
N
S
L
T
G
Q
Y
L
S
----
G
K
K
--------
F
I
--
P
-------
I
---
P
--
A
E
R
--
R
R
P
D
-
G
R
W
L
E
V
V
G
A
----
R
----
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----
H
N
L
K
N
V
S
V
K
I
P
L
G
T
F
V
A
V
T
G
V
S
G
S
G
K
S
T
L
V
N
E
V
L
Y
---------
K
A
L
A
Q
K
L
H
R
A
K
A
K
P
------
G
E
H
--
R
D
I
R
G
--
L
E
H
L
-
D
K
V
I
D
I
D
Q
S
P
I
G
R
T
P
R
S
N
P
A
T
Y
T
G
V
F
D
D
I
R
D
V
F
A
S
T
N
E
A
K
V
--
R
G
Y
K
K
G
R
F
S
F
N
V
K
G
G
R
C
E
A
C
H
G
D
G
I
I
K
I
E
-
M
H
------------------------------------------------------------------------------------
F
L
P
----------------------------
D
V
Y
V
P
C
E
V
C
H
G
K
R
Y
N
R
E
T
L
E
V
T
Y
K
G
K
N
I
A
E
V
L
D
M
T
V
E
D
A
L
D
F
F
A
S
I
--------------------------
P
K
I
K
R
K
L
E
T
L
Y
D
V
G
L
G
Y
M
K
L
G
Q
P
A
T
T
L
S
G
G
E
A
Q
R
V
K
L
A
A
E
L
H
R
R
S
N
G
R
T
L
Y
I
L
D
E
P
T
T
G
L
H
V
D
D
I
A
R
L
L
D
V
L
H
R
L
V
D
-
N
G
D
T
V
L
V
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E
H
N
L
D
V
I
-
K
-
T
A
D
Y
I
I
D
L
G
P
E
G
G
D
R
G
G
Q
I
V
A
V
G
T
P
E
E
V
A
---
E
V
K
-
E
S
H
T
G
R
Y
L
K
P
I
L
E
3
PsiBlast_PDB
91.45
48%
-73
- C3 -
3ZQJ
3
UVRA_MYCTU
A:
[23-971]
------
A
D
R
L
I
V
K
G
A
R
E
H
N
L
R
S
V
D
L
D
L
P
R
D
A
L
I
V
F
T
G
L
S
G
S
G
K
S
S
L
A
F
D
T
I
F
A
E
G
Q
R
R
Y
V
E
S
L
S
A
Y
A
R
Q
F
L
G
Q
M
D
K
P
D
V
D
F
I
E
G
L
S
P
A
V
S
I
D
Q
K
S
T
N
R
N
P
R
S
T
V
G
T
I
T
E
V
Y
D
Y
L
R
L
L
Y
A
R
A
G
T
P
H
C
P
T
C
G
E
R
V
A
R
Q
T
P
Q
Q
I
V
D
Q
V
L
A
M
P
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T
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F
L
V
L
A
P
V
V
R
T
R
K
G
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A
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L
F
D
K
L
N
A
Q
G
Y
S
R
V
R
V
D
G
V
V
H
P
L
T
D
P
P
K
L
K
K
Q
E
K
H
D
I
E
V
V
V
D
R
L
T
V
K
A
A
A
K
R
R
L
T
D
S
V
E
T
A
L
N
L
A
D
G
I
V
V
L
E
F
V
D
------
E
Q
R
F
S
E
K
L
A
C
P
N
G
H
A
L
A
V
D
D
L
E
P
R
S
F
S
F
N
S
P
Y
G
A
C
P
E
C
S
G
L
G
I
R
K
E
V
-
D
P
E
L
V
V
P
D
P
D
R
T
L
A
--
Q
G
A
V
A
P
W
S
N
G
H
T
A
E
Y
F
T
R
M
M
A
G
L
G
E
A
L
G
F
D
V
D
T
P
W
R
K
L
P
A
K
A
R
K
A
I
L
E
G
A
D
E
Q
-
V
-
H
V
R
Y
-----------
R
N
---
R
YGRTR
S
Y
Y
A
D
F
---
E
G
V
L
AF
L
Q
R
K
M
S
Q
T
E
S
------------------
E
Q
M
K
----------
E
------
R
Y
E
--
G
F
M
R
D
V
P
C
P
V
C
A
G
T
R
L
K
P
E
I
L
A
V
T
L
A
G
E
S
K
G
E
H
G
A
K
S
I
A
E
V
C
E
L
S
I
A
D
C
A
D
F
L
N
------
A
L
T
----
L
-
G
P
R
E
Q
A
I
A
-
G
Q
----
V
L
K
E
I
R
S
R
L
G
F
L
L
D
V
G
L
E
Y
L
S
L
S
R
A
A
A
T
L
S
G
G
E
A
Q
R
I
R
L
A
T
Q
I
G
S
G
L
V
-
G
V
L
Y
V
L
D
E
P
S
I
G
L
H
Q
R
D
N
R
R
L
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T
L
T
R
L
R
D
L
G
N
T
L
I
V
V
E
H
D
E
D
T
I
E
-
H
-
A
D
W
I
V
D
I
G
P
G
A
G
E
H
G
G
R
I
V
H
S
G
P
Y
D
E
L
L
R
N
K
---
D
S
I
T
G
A
Y
L
S
----
G
R
E
--------
S
I
--
E
-------
I
---
P
--
A
I
R
--
R
S
V
D
P
R
R
Q
L
T
V
V
G
A
----
R
----
E
----
H
N
L
R
G
I
D
V
S
F
P
L
G
V
L
T
S
V
T
G
V
S
G
S
G
K
S
T
L
V
N
D
I
L
A
---------
A
V
L
A
N
R
L
N
G
A
R
Q
V
P
------
G
R
H
--
T
R
V
T
G
--
L
D
Y
L
-
D
K
L
V
R
V
D
Q
S
P
I
G
R
T
P
R
S
N
P
A
T
Y
T
G
V
F
D
K
I
R
T
L
F
A
A
T
T
E
A
K
V
--
R
G
Y
Q
P
G
R
F
S
F
N
V
K
G
G
R
C
E
A
C
T
G
D
G
T
I
K
I
E
-
M
N
------------------------------------------------------------------------------------
F
L
P
----------------------------
D
V
Y
V
P
C
E
V
C
Q
G
A
R
Y
N
R
E
T
L
E
V
H
Y
K
G
K
T
V
S
E
V
L
D
M
S
I
E
E
A
A
E
F
F
E
P
I
--------------------------
A
G
V
H
R
Y
L
R
T
L
V
D
V
G
L
G
Y
V
R
L
G
Q
P
A
P
T
L
S
G
G
E
A
Q
R
V
K
L
A
S
E
L
Q
K
R
S
T
G
R
T
V
Y
I
L
D
E
P
T
T
G
L
H
F
D
D
I
R
K
L
L
N
V
I
N
G
L
V
D
-
K
G
N
T
V
I
V
I
E
H
N
L
D
V
I
-
K
-
T
S
D
W
I
I
D
L
G
P
E
G
G
A
G
G
G
T
V
V
A
Q
G
T
P
E
D
V
A
A
---
V
P
-
A
S
Y
T
G
K
F
L
A
E
V
V
-
21
PsiBlast_CBE
90.38
48%
-72
- C3 -
3ZQJ
2
UVRA_MYCTU
E:
[23-971]
------
A
D
R
L
I
V
K
G
A
R
E
H
N
L
R
S
V
D
L
D
L
P
R
D
A
L
I
V
F
T
G
L
S
G
S
G
K
S
S
L
A
F
D
T
I
F
A
E
G
Q
R
R
Y
V
E
S
L
S
A
Y
A
R
Q
F
L
G
Q
M
D
K
P
D
V
D
F
I
E
G
L
S
P
A
V
S
I
D
Q
K
S
T
N
R
N
P
R
S
T
V
G
T
I
T
E
V
Y
D
Y
L
R
L
L
Y
A
R
A
G
T
P
H
C
P
------
A
R
Q
T
P
Q
Q
I
V
D
Q
V
L
A
M
P
E
G
T
R
F
L
V
L
A
P
V
V
R
T
R
K
G
E
F
A
D
L
F
D
K
L
N
A
Q
G
Y
S
R
V
R
V
D
G
V
V
H
P
L
T
D
P
P
K
L
K
K
Q
E
K
H
D
I
E
V
V
V
D
--------
K
R
R
L
T
D
S
V
E
T
A
L
N
L
A
D
G
I
V
V
L
E
F
V
D
H
------------
L
A
C
P
N
G
H
A
L
A
V
D
D
L
E
P
R
S
F
S
F
N
S
P
Y
G
A
C
P
E
C
S
G
L
G
I
R
K
E
V
-
D
P
E
L
V
V
P
D
P
D
R
T
L
A
--
Q
G
A
V
A
P
W
S
N
G
H
T
A
E
Y
F
T
R
M
M
A
G
L
G
E
A
L
G
F
D
V
D
T
P
W
--
L
P
A
K
A
R
K
A
I
L
E
G
A
D
E
Q
-
V
-
H
V
R
Y
-----------
R
N
---
R
YGRTR
S
Y
Y
A
D
F
---
E
G
V
L
A
F
L
Q
R
K
M
S
Q
T
E
S
------------------
E
Q
M
K
----------
E
------
R
Y
E
--
G
F
M
R
D
V
P
C
P
V
C
A
G
T
R
L
K
P
E
I
L
A
V
T
L
A
---
K
G
E
H
G
A
K
S
I
A
E
V
C
E
L
S
I
A
D
CAD
F
L
N
------
A
L
T
----
L
-
G
P
R
E
Q
A
I
A
-
G
Q
----
V
L
K
E
I
R
S
R
L
G
F
L
L
D
V
G
L
E
Y
L
S
L
S
R
A
A
A
T
L
S
G
G
E
A
Q
R
I
R
L
A
T
Q
I
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S
G
L
V
-
G
V
L
Y
V
L
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S
I
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L
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N
R
R
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L
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L
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V
E
H
D
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-
H
-
A
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W
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V
D
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A
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G
G
R
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H
S
G
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Y
D
E
L
L
R
N
K
---
D
S
I
T
G
A
Y
L
S
----
G
R
E
--------
S
I
--
E
-------
I
---
P
--
A
I
R
--
R
S
V
D
P
R
R
Q
L
T
V
V
G
A
----
R
----
E
----
H
N
L
R
G
I
D
V
S
F
P
L
G
V
L
T
S
V
T
G
V
S
G
S
G
K
S
T
L
V
N
D
I
L
A
---------
A
V
L
A
N
R
L
N
G
A
R
Q
V
P
------
G
R
H
--
T
R
V
T
G
--
L
D
Y
L
-
D
K
L
V
R
V
D
Q
S
P
I
G
R
T
P
R
S
N
P
A
T
Y
T
G
V
F
D
K
I
R
T
L
F
A
A
T
T
E
A
K
V
--
R
G
Y
Q
P
G
R
F
S
F
N
V
K
G
G
R
C
E
A
C
T
G
D
G
T
I
K
I
E
-
M
N
------------------------------------------------------------------------------------
F
L
P
----------------------------
D
V
Y
V
P
C
E
V
C
Q
G
A
R
Y
N
R
E
T
L
E
V
H
Y
K
G
K
T
V
S
E
V
L
D
M
S
I
E
E
A
A
E
F
F
E
P
I
--------------------------
A
G
V
H
R
Y
L
R
T
L
V
D
V
G
L
G
Y
V
R
L
G
Q
P
A
P
T
L
S
G
G
E
A
Q
R
V
K
L
A
S
E
L
Q
K
R
S
T
G
R
T
V
Y
I
L
D
E
P
T
T
G
L
H
F
D
D
I
R
K
L
L
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V
I
N
G
L
V
D
-
K
G
N
T
V
I
V
I
E
H
N
L
D
V
I
-
K
-
T
S
D
W
I
I
D
L
G
P
E
G
G
A
G
G
G
T
V
V
A
Q
G
T
P
E
D
V
A
A
---
V
P
-
A
S
Y
T
G
K
F
L
A
E
V
V
-
23
PsiBlast_CBE
90.20
48%
-73
- C3 -
3ZQJ
3
UVRA_MYCTU
B:
[23-971]
------
A
D
R
L
I
V
K
G
A
R
E
H
N
L
R
S
V
D
L
D
L
P
R
D
A
L
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V
F
T
G
L
S
G
S
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K
S
S
L
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T
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F
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G
Q
R
R
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L
S
A
Y
A
R
Q
F
L
G
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M
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K
P
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L
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K
S
T
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R
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S
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Y
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L
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L
L
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P
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V
V
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K
L
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Q
G
Y
S
R
V
R
V
D
G
V
V
H
P
L
T
D
P
P
K
L
K
K
Q
E
K
H
D
I
E
V
V
V
D
--------
K
R
R
L
T
D
S
V
E
T
A
L
N
L
A
D
G
I
V
V
L
-------------
F
S
E
K
L
A
C
P
N
G
H
A
L
A
V
D
D
L
E
P
R
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F
S
F
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S
P
Y
G
A
C
P
E
C
S
G
L
G
I
R
K
E
V
-
D
P
E
L
V
V
P-------------
A
P
W
S
N
G
H
T
A
E
Y
F
T
R
M
M
A
G
L
G
E
A
L
G
F
D
V
D
T
P
W
R
K
L
P
A
K
A
R
K
A
I
L
E
G
A
D
E
Q
-
V
-
H
V
R
Y
-----------
R
N
---
R
YG
R
T
R
S
Y
Y
A
D
F
---
E
G
V
L
AF
L
Q
R
K
M
S
Q
T
E
S
------------------
E
Q
M
K
----------
E
------
R
Y
E
--
G
F
M
R
D
V
P
C
P
V
C
A
G
T
R
L
K
P
E
I
L
A
V
T
L
A
G
E
S
K
G
E
H
G
A
K
S
I
A
E
V
C
E
L
S
I
A
D
CAD
F
L
N
------
A
L
T
----
L
-
G
P
R
E
Q
A
I
A
-
G
Q
----
V
L
K
E
I
R
S
R
L
G
F
L
L
D
V
G
L
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Y
L
S
L
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A
A
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G
G
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A
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A
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L
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-
G
V
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A
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L
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---
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S
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----
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R
E
--------
S
I
--
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-------
I
---
P
--
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R
--
R
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V
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P
R
R
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L
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V
V
G
A
----
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----
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----
H
N
L
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G
I
D
V
S
F
P
L
G
V
L
T
S
V
T
G
V
S
G
S
G
K
S
T
L
V
N
D
I
L
A
---------
A
V
L
A
N
R
L
N
G
A
R
Q
V
P
------
G
R
H
--
T
R
V
T
G
--
L
D
Y
L
-
D
K
L
V
R
V
D
Q
S
P
I
G
R
T
P
R
S
N
P
A
T
Y
T
G
V
F
D
K
I
R
T
L
F
A
A
T
T
E
A
K
V
--
R
G
Y
Q
P
G
R
F
S
F
N
V
K
G
G
R
C
E
A
C
T
G
D
G
T
I
K
I
E
-
M
N
------------------------------------------------------------------------------------
F
L
P
----------------------------
D
V
Y
V
P
C
E
V
C
Q
G
A
R
Y
N
R
E
T
L
E
V
H
Y
K
G
K
T
V
S
E
V
L
D
M
S
I
E
E
A
A
E
F
F
E
P
I
--------------------------
A
G
V
H
R
Y
L
R
T
L
V
D
V
G
L
G
Y
V
R
L
G
Q
P
A
P
T
L
S
G
G
E
A
Q
R
V
K
L
A
S
E
L
Q
K
R
S
T
G
R
T
V
Y
I
L
D
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P
T
T
G
L
H
F
D
D
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K
L
L
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V
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N
G
L
V
D
-
K
G
N
T
V
I
V
I
E
H
N
L
D
V
I
-
K
-
T
S
D
W
I
I
D
L
G
P
E
G
G
A
G
G
G
T
V
V
A
Q
G
T
P
E
D
V
A
A
---
V
P
-
A
S
Y
T
G
K
F
L
A
E
V
V
-
22
PsiBlast_CBE
89.77
48%
-74
- C3 -
3ZQJ
3
UVRA_MYCTU
C:
[23-971]
------
A
D
R
L
I
V
K
G
A
R
E
H
N
L
R
S
V
D
L
D
L
P
R
D
A
L
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V
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T
G
L
S
G
S
G
K
S
S
L
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T
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F
A
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G
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R
R
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L
S
A
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A
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F
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P
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L
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S
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K
S
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N
R
N
P
R
S
T
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T
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T
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Y
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Y
L
R
L
L
Y
A
R
A
G
T
P
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C
P
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C
G
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R
V
A
R
Q
T
P
Q
Q
I
V
D
Q
V
L
A
M
P
------
V
L
A
P
V
V
R
T
R
K
G
E
F
A
D
L
F
D
K
L
N
A
Q
G
Y
S
R
V
R
V
D
G
V
V
H
P
L
T
D
P
P
K
L
K
K
Q
E
K
H
D
I
E
V
V
----------
K
R
R
L
T
D
S
V
E
T
A
L
N
L
A
D
G
I
V
V
------------------
L
A
C
P
N
G
H
A
L
A
V
D
D
L
E
P
R
S
F
S
F
N
S
P
Y
G
A
C
P
E
C
S
G
L
G
I
R
K
E
V
-
D
P
E
L
V
V
P-----------
A
V
A
P
W
S
N
G
H
T
A
E
Y
F
T
R
M
M
A
G
L
G
E
A
L
G
------------
K
A
R
K
A
I
L
E
G
A
D
E
Q
-
V
-
H
V
R
Y
-----------
R
N
---
R
YGR
T
R
S
Y
Y
A
D
F
---
E
G
V
L
AFL
Q
R
K
M
S
Q
T
E
S
------------------
E
Q
M
K
----------
E
------
R
Y
E
--
G
F
M
R
D
V
P
C
P
V
C
A
G
T
R
L
K
P
E
I
L
A
V
T
L
A
G
-----
H
G
A
K
S
I
A
E
V
C
E
LSIADCAD
F
L
N
------
A
L
T
----
L
-
G
P
R
E
Q
A
I
A
-
G
Q
----
V
L
K
E
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R
S
R
L
G
F
L
L
D
V
G
L
E
Y
L
S
L
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R
A
A
A
T
L
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G
G
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A
Q
R
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R
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A
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Q
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G
L
V
-
G
V
L
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P
Y
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L
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N
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---
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S
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T
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A
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L
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----
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R
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--------
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--
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-------
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---
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--
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--
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G
A
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----
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----
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L
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G
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K
S
T
L
V
N
D
I
L
A
---------
A
V
L
A
N
R
L
N
G
A
R
Q
V
P
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G
R
H
--
T
R
V
T
G
--
L
D
Y
L
-
D
K
L
V
R
V
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A
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--
R
G
Y
Q
P
G
R
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F
N
V
K
G
G
R
C
E
A
C
T
G
D
G
T
I
K
I
E
-
M
N
------------------------------------------------------------------------------------
F
L
P
----------------------------
D
V
Y
V
P
C
E
V
C
Q
G
A
R
Y
N
R
E
T
L
E
V
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Y
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K
T
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S
E
V
L
D
M
S
I
E
E
A
A
E
F
F
E
P
I
--------------------------
A
G
V
H
R
Y
L
R
T
L
V
D
V
G
L
G
Y
V
R
L
G
Q
P
A
P
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G
G
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A
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L
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L
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K
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G
A
G
G
G
T
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V
A
Q
G
T
P
E
D
V
A
A
---
V
P
-
A
S
Y
T
G
K
F
L
A
E
V
V
-
132
HHSearch
82.56
41%
-84
- C3 -
2VF7
4
?
A:
[11-841]
----
P
D
G
G
F
V
Q
V
R
G
A
R
Q
H
N
L
K
D
I
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K
V
P
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V
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T
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V
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G
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G
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L
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A
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A
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D
A
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A
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S
N
L
L
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M
L
Y
S
R
A
G
D
Y
P
P
G
-
Q
G
I
-------------------------------------------------------------------------------------------------------------------------------------------
V
Y
A
E
G
F
S
P
N
T
P
E
G
A
C
P
E
C
H
G
L
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P
S
L
T
I
R
--
E
R
A
V
A
A
W
P
-
Q
A
W
---
G
G
Q
N
Q
R
D
I
L
V
T
L
G
I
D
V
D
V
P
W
R
E
L
P
E
E
T
R
H
W
I
L
F
T
D
E
Q
P
-
V
-
V
P
V
Y
P
GLT
P
A
E
T
Q
R
A
L
K
---
K
-----
K
M
E
P
S
Y
---
M
G
T
F
--------
S
S
A
R
------------------
R
H
V
L
H
T
F
A
NTES
A
S
M
------
K
K
R
V
Q
G
Y
M
I
S
E
E
C
P
L
C
H
G
K
R
L
R
Q
E
A
L
N
V
T
F
A
G
L
D
I
T
E
L
S
R
L
P
L
A
R
V
S
E
--------
L
L
R
PYAE--
E
R
E
P
G
H
A
E
-
R
V
K
N
R
P
E
Q
-
A
I
A
L
Q
R
M
A
A
D
L
V
K
R
L
D
V
L
L
H
L
G
L
G
Y
L
G
L
D
R
S
T
P
T
L
S
P
G
E
L
Q
R
L
R
L
A
T
Q
L
Y
S
N
L
F
-
G
V
V
Y
V
L
D
E
P
S
A
G
L
H
P
A
D
T
E
A
L
L
S
A
L
E
N
L
K
R
G
G
N
S
L
F
V
V
E
H
D
L
D
V
I
R
-
R
-
A
D
W
L
V
D
V
G
P
E
A
G
E
K
G
G
E
I
L
Y
S
G
P
P
E
G
L
K
H
V
P
E--
S
Q
-
T
G
Q
Y
L
F
----
A
D
R
--------
H
T
--
E
-------
P
---
H
----
T
--
P
R
E
P
-
A
G
W
L
E
L
N
G
V
----
T
----
R
----
N
N
L
D
N
L
D
V
R
F
P
L
G
V
M
T
S
V
T
G
V
S
G
S
G
K
S
T
L
V
S
Q
A
L
V
---------
D
A
L
A
A
H
F
G
Q
--------------
G
S
A
R
L
G
G
D-
L
A
Q
I
-
T
R
L
V
R
V
D
Q
K
P
I
G
R
T
P
R
S
N
M
A
T
Y
T
G
L
F
D
Q
V
R
K
L
F
A
A
T
P
L
A
K
K
--
R
G
Y
N
A
G
R
F
S
F
N
V
K
G
G
R
C
E
H
C
Q
G
E
G
W
V
M
V
E
-
L
L
------------------------------------------------------------------------------------
F
L
P
----------------------------
S
V
Y
A
P
C
P
V
C
H
G
T
R
Y
N
A
E
T
L
E
V
E
Y
R
G
K
N
I
A
D
V
L
A
L
T
V
D
E
A
H
D
F
F
A
D
E
--------------------------
S
A
I
F
R
A
L
D
T
L
R
E
V
G
L
G
Y
L
R
L
G
Q
P
A
T
E
L
S
G
G
E
A
Q
R
I
K
L
A
T
E
L
R
R
S
G
R
G
G
T
V
Y
V
L
D
E
P
T
T
G
L
H
P
A
D
V
E
R
L
Q
R
Q
L
V
K
L
V
D
-
A
G
N
T
V
I
A
V
E
H
K
M
Q
V
V
-
A
-
A
S
D
W
V
L
D
I
G
P
G
A
G
E
D
G
G
R
L
V
A
Q
G
T
P
A
E
V
A
Q
A
---
A
-
G
S
V
T
A
P
Y
L
R
A
A
L
R
4
PsiBlast_PDB
71.22
38%
-72
- C3 -
2VF7
4
?
A:
[142-842]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
S
P
N
T
P
E
G
A
C
P
E
C
H
G
L
G
R
V
Y
T
V
T
E
D
S
M
V
P
-
D
P
S
L
T
I
R
--
E
---
R
A
V
A
-
A
W
P
Q
A
W
G
G
Q
N
Q
R
D
I
L
V
T
L
G
I
D
V
D
V
P
W
R
E
L
P
E
E
T
R
H
W
I
L
F
T
D
E
Q
P
-
V
-
V
P
V
Y
-----------
P
G
LT
P
A
-----
E
T
Q
R
A
L
---
K
K
K
M
--------
E
P
S
Y
M
G
T
F
S
S
A
R
R
H
V
L
H
T
F
A
NT
E
S
A
S
----------
M
------
K
K
R
V
Q
G
Y
M
I
S
E
E
C
P
L
C
H
G
K
R
L
R
Q
E
A
L
N
V
T
F
A
G
L
D
I
T
E
L
S
R
L
P
L
A
R
V
S
E
--------
L
L
R
PYAEER
E
P
G
H
A
E
R
V
K
N
R
P
E
Q
A
I
A
L
Q
R
----
M
A
A
D
L
V
K
R
L
D
V
L
L
H
L
G
L
G
Y
L
G
L
D
R
S
T
P
T
L
S
P
G
E
L
Q
R
L
R
L
A
T
Q
L
Y
S
N
L
F
-
G
V
V
Y
V
L
D
E
P
S
A
G
L
H
P
A
D
T
E
A
L
L
S
A
L
E
N
L
K
R
G
G
N
S
L
F
V
V
E
H
D
L
D
V
I
R
-
R
-
A
D
W
L
V
D
V
G
P
E
A
G
E
K
G
G
E
I
L
Y
S
G
P
P
E
G
L
K
H
V
P
---
E
S
Q
T
G
Q
Y
L
F
----
A
D
R
--------
H
T
--
E
--------------
P
H
T
--
P
R
E
P
-
A
G
W
L
E
L
N
G
V
----
T
----
R
----
N
N
L
D
N
L
D
V
R
F
P
L
G
V
M
T
S
V
T
G
V
S
G
S
G
K
S
T
L
V
S
Q
A
L
V
D
A
L
A
A
H
F
GQ-----------------------
G
-
S
A
R
L
G
G
D
L
A
Q
I
-
T
R
L
V
R
V
D
Q
K
P
I
G
R
T
P
R
S
N
M
A
T
Y
T
G
L
F
D
Q
V
R
K
L
F
A
A
T
P
L
A
K
K
--
R
G
Y
N
A
G
R
F
S
F
N
V
K
G
G
R
C
E
H
C
Q
G
E
G
W
V
M
V
E
-
L
L
------------------------------------------------------------------------------------
F
L
P
----------------------------
S
V
Y
A
P
C
P
V
C
H
G
T
R
Y
N
A
E
T
L
E
V
E
Y
R
G
K
N
I
A
D
V
L
A
L
T
V
D
E
A
H
D
F
F
A
D
E
--------------------------
S
A
I
F
R
A
L
D
T
L
R
E
V
G
L
G
Y
L
R
L
G
Q
P
A
T
E
L
S
G
G
E
A
Q
R
I
K
L
A
T
E
L
R
R
S
G
R
G
G
T
V
Y
V
L
D
E
P
T
T
G
L
H
P
A
D
V
E
R
L
Q
R
Q
L
V
K
L
V
D
-
A
G
N
T
V
I
A
V
E
H
K
M
Q
V
V
-
A
-
A
S
D
W
V
L
D
I
G
P
G
A
G
E
D
G
G
R
L
V
A
Q
G
T
P
A
E
V
A
Q
A
A
----
G
S
V
T
A
P
Y
L
R
A
A
L
R
26
PsiBlast_CBE
70.71
38%
-72
- C3 -
2VF7
4
?
B:
[142-842]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
S
P
N
T
P
E
G
A
C
P
E
C
H
G
L
G
R
V
Y
T
V
T
E
D
S
M
V
P
-
D
P
S
L
T
I
R
--
E
---
R
A
V
A
-
A
W
P
Q
A
W
G
G
Q
N
Q
R
D
I
L
V
T
L
G
I
D
V
D
V
P
W
R
E
L
P
E
E
T
R
H
W
I
L
F
T
D
E
Q
P
-
V
-
V
P
V
Y
-----------
P
G
LT
P
A
-----
E
T
Q
R
A
L
---
K
K
K
M
--------
E
P
S
Y
M
G
T
F
S
S
A
R
R
H
V
L
H
T
F
A
NT
E
S
A
S
----------
M
------
K
K
R
V
Q
G
Y
M
I
S
E
E
C
P
L
C
H
G
K
R
L
R
Q
E
A
L
N
V
T
F
A
G
L
D
I
T
E
L
S
R
L
P
L
A
R
V
S
E
--------
L
L
R
PYAEER
E
P
G
H
A
E
R
V
K
N
R
P
E
Q
A
I
A
L
Q
R
----
M
A
A
D
L
V
K
R
L
D
V
L
L
H
L
G
L
G
Y
L
G
L
D
R
S
T
P
T
L
S
P
G
E
L
Q
R
L
R
L
A
T
Q
L
Y
S
N
L
F
-
G
V
V
Y
V
L
D
E
P
S
A
G
L
H
P
A
D
T
E
A
L
L
S
A
L
E
N
L
K
R
G
G
N
S
L
F
V
V
E
H
D
L
D
V
I
R
-
R
-
A
D
W
L
V
D
V
G
P
E
A
G
E
K
G
G
E
I
L
Y
S
G
P
P
E
G
L
K
H
V
P
---
E
S
Q
T
G
Q
Y
L
F
----
A
D
R
--------
H
T
--
E
--------------
P
H
T
--
P
R
E
P
-
A
G
W
L
E
L
N
G
V
----
T
----
R
----
N
N
L
D
N
L
D
V
R
F
P
L
G
V
M
T
S
V
T
G
V
S
G
S
G
K
S
T
L
V
S
Q
A
L
V
D
A
L
A
A
H
F
GQ-----------------------
G
-
S
A
R
L
G
G
D
L
A
Q
I
-
T
R
L
V
R
V
D
Q
K
P
I
G
R
T
P
R
S
N
M
A
T
Y
T
G
L
F
D
Q
V
R
K
L
F
A
A
T
P
L
A
K
K
--
R
G
Y
N
A
G
R
F
S
F
N
V
K
G
G
R
C
E
H
C
Q
G
E
G
W
V
M
V
------------------------------------------------------------------------------------------
P
----------------------------
S
V
Y
A
P
C
P
V
C
H
G
T
R
Y
N
A
E
T
L
E
V
E
Y
R
G
K
N
I
A
D
V
L
A
L
T
V
D
E
A
H
D
F
F
A
D
E
--------------------------
S
A
I
F
R
A
L
D
T
L
R
E
V
G
L
G
Y
L
R
L
G
Q
P
A
T
E
L
S
G
G
E
A
Q
R
I
K
L
A
T
E
L
R
R
S
G
R
G
G
T
V
Y
V
L
D
E
P
T
T
G
L
H
P
A
D
V
E
R
L
Q
R
Q
L
V
K
L
V
D
-
A
G
N
T
V
I
A
V
E
H
K
M
Q
V
V
-
A
-
A
S
D
W
V
L
D
I
G
P
G
A
G
E
D
G
G
R
L
V
A
Q
G
T
P
A
E
V
A
Q
A
A
----
G
S
V
T
A
P
Y
L
R
A
A
L
R
25
PsiBlast_CBE
70.57
38%
-70
- C3 -
2VF7
5
?
C:
[142-842]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
S
P
N
T
P
E
G
A
C
P
E
C
H
G
L
G
R
V
Y
T
V
T
E
D
S
M
V
P
-
D
P
S
L
T
I
R
--
E
---
R
A
V
A
-
A
W
P
Q
A
W
G
G
Q
N
Q
R
D
I
L
V
T
L
G
I
D
V
D
V
P
W
R
E
L
P
E
E
T
R
H
W
I
L
F
T
D
E
Q
P
-
V
-
V
P
V
Y
-----------
P
G
LT
P
A
-----
E
T
Q
R
A
L
---
K
K
K
M
--------
E
P
S
Y
M
G
T
F
S
S
A
R
R
H
V
L
H
T
F
A
NT
E
S
A
S
----------
M
------
K
K
R
V
Q
G
Y
M
I
S
E
E
C
P
L
C
H
G
K
R
L
R
Q
E
A
L
N
V
T
F
A
G
L
D
I
T
E
L
S
R
L
P
L
A
R
V
S
E
--------
L
L
R
PYAEER
E
P
G
H
A
E
R
V
K
N
R
P
E
Q
A
I
A
L
Q
R
----
M
A
A
D
L
V
K
R
L
D
V
L
L
H
L
G
L
G
Y
L
G
L
D
R
S
T
P
T
L
S
P
G
E
L
Q
R
L
R
L
A
T
Q
L
Y
S
N
L
F
-
G
V
V
Y
V
L
D
E
P
S
A
G
L
H
P
A
D
T
E
A
L
L
S
A
L
E
N
L
K
R
G
G
N
S
L
F
V
V
E
H
D
L
D
V
I
R
-
R
-
A
D
W
L
V
D
V
G
P
E
A
G
E
K
G
G
E
I
L
Y
S
G
P
P
E
G
L
K
H
V
P
---
E
S
Q
T
G
Q
Y
L
F
----
A
D
R
--------
H
T
--
E
--------------
P
H
T
--
P
R
E
P
-
A
G
W
L
E
L
N
G
V
----
T
----
R
----
N
N
L
D
N
L
D
V
R
F
P
L
G
V
M
T
S
V
T
G
V
S
G
S
G
K
S
T
L
V
S
Q
A
L
V
D
A
L
A
A
H
FG--------------------------
S
A
R
L
G
G
D
L
A
Q
I
-
T
R
L
V
R
V
D
Q
K
P
I
G
R
T
P
R
S
N
M
A
T
Y
T
G
L
F
D
Q
V
R
K
L
F
A
A
T
P
L
A
K
K
--
R
G
Y
N
A
G
R
F
S
F
N
V
K
G
G
R
C
E
H
C
Q
G
E
G
W
V
M
V
E
-
L
L
------------------------------------------------------------------------------------
F
L
P
----------------------------
S
V
Y
A
P
C
P
V
C
H
G
T
R
Y
N
A
E
T
L
E
V
E
Y
R
G
K
N
I
A
D
V
L
A
L
T
V
D
E
A
H
D
F
F
A
D
E
--------------------------
S
A
I
F
R
A
L
D
T
L
R
E
V
G
L
G
Y
L
R
L
G
Q
P
A
T
E
L
S
G
G
E
A
Q
R
I
K
L
A
T
E
L
R
R
S
G
R
G
G
T
V
Y
V
L
D
E
P
T
T
G
L
H
P
A
D
V
E
R
L
Q
R
Q
L
V
K
L
V
D
-
A
G
N
T
V
I
A
V
E
H
K
M
Q
V
V
-
A
-
A
S
D
W
V
L
D
I
G
P
G
A
G
E
D
G
G
R
L
V
A
Q
G
T
P
A
E
V
A
Q
A
A
----
G
S
V
T
A
P
Y
L
R
A
A
L
R
5
PsiBlast_PDB
69.66
38%
-72
- C3 -
2VF8
7
?
A:
[142-842]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
S
P
N
T
P
E
G
A
C
P
E
C
H
G
L
G
R
V
Y
T
V
T
E
D
S
M
V
P
-
D
P
S
L
T
I
R
--
E
---
R
A
V
A
-
A
W
P
Q
A
W
G
G
Q
N
Q
R
D
I
L
V
T
L
G
I
D
V
D
V
P
W
R
E
L
P
E
E
T
R
H
W
I
L
F
T
D
E
Q
P
-
V
-
V
P
V
Y
-----------
P
G
LT
P
A
-----
E
T
Q
R
A
L
---
K
K
K
M
--------
E
P
S
Y
M
G
T
F
S
S
A
R
R
H
V
L
H
T
F
A
NT
E
S
A
S
----------
M
------
K
K
R
V
Q
G
Y
M
I
S
E
E
C
P
L
C
H
G
K
R
L
R
Q
E
A
L
N
V
T
F
A
G
L
D
I
T
E
L
S
R
L
P
L
A
R
V
S
E
--------
L
L
R
PYAEER
E
P
G
H
A
E
R
V
K
N
R
P
E
Q
A
I
A
L
Q
R
----
M
A
A
D
L
V
K
R
L
D
V
L
L
H
L
G
L
G
Y
L
G
L
D
R
S
T
P
T
L
S
P
G
E
L
Q
R
L
R
L
A
T
Q
L
Y
S
N
L
F
-
G
V
V
Y
V
L
D
E
P
S
A
G
L
H
P
A
D
T
E
A
L
L
S
A
L
E
N
L
K
R
G
G
N
S
L
F
V
V
E
H
D
L
D
V
I
R
-
R
-
A
D
W
L
V
D
V
G
P
E
A
G
E
K
G
G
E
I
L
Y
S
G
P
P
E
G
L
K
H
V
P
---
E
S
Q
T
G
Q
Y
L
F
----
A
D
-------------
E
--------------
P
H
T
--
P
R
E
P
-
A
G
W
L
E
L
N
G
V
----
T
----
R
----
N
N
L
D
N
L
D
V
R
F
P
L
G
V
M
T
S
V
T
G
V
S
G
S
G
K
S
T
L
V
S
Q
A
L
V
D
A
L
A
A
H
F
GQ-----------------------
G
-
S
A
R
L
G
G
D
L
A
Q
I
-
T
R
L
V
R
V
D
Q
K
P
I
G
R
T
P
R
S
N
M
A
T
Y
T
G
L
F
D
Q
V
R
K
L
F
A
A
T
P
L
A
K
K
--
R
G
Y
N
A
G
R
F
S
F
N
V
K
G
G
R
C
E
H
C
Q
G
E
G
W
V
M
V
------------------------------------------------------------------------------------------
P
----------------------------
S
V
Y
A
P
C
P
V
C
H
G
T
R
Y
N
A
E
T
L
E
V
E
Y
R
G
K
N
I
A
D
V
L
A
L
T
V
D
E
A
H
D
F
F
A
D
E
--------------------------
S
A
I
F
R
A
L
D
T
L
R
E
V
G
L
G
Y
L
R
L
G
Q
P
A
T
E
L
S
G
G
E
A
Q
R
I
K
L
A
T
E
L
R
R
S
G
R
G
G
T
V
Y
V
L
D
E
P
T
T
G
L
H
P
A
D
V
E
R
L
Q
R
Q
L
V
K
L
V
D
-
A
G
N
T
V
I
A
V
E
H
K
M
Q
V
V
-
A
-
A
S
D
W
V
L
D
I
G
P
G
A
G
E
D
G
G
R
L
V
A
Q
G
T
P
A
E
V
A
Q
A
A
----
G
S
V
T
A
P
Y
L
R
A
A
L
R
24
PsiBlast_CBE
68.48
38%
-67
- C3 -
2VF8
9
?
B:
[142-842]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
S
P
N
T
P
E
G
A
C
P
E
C
H
G
L
G
R
V
Y
T
V
T
E
D
S
M
V
P
-
D
P
S
L
T
I
R
--
E
---
R
A
V
A
-
A
W
P
Q
A
W
G
G
Q
N
Q
R
D
I
L
V
T
L
G
I
D
V
D
V
P
W
R
E
L
P
E
E
T
R
H
W
I
L
F
T
D
E
Q
P
-
V
-
V
P
V
Y
-----------
P
G
LT
P
A
-----
E
T
Q
R
A
L
---
K
K
K
M
--------
E
P
S
Y
M
G
T
F
S
S
A
R
R
H
V
L
H
T
F
A
N
T
E
S
A
S
----------
M
------
K
K
R
V
Q
G
Y
M
I
S
E
E
C
P
L
C
H
G
K
R
L
R
Q
E
A
L
N
V
T
F
A
G
L
D
I
T
E
L
S
R
L
P
L
A
R
V
S
E
--------
L
L
R
PYAEER
E
P
G
H
A
E
R
V
K
N
R
P
E
Q
A
I
A
L
Q
R
----
M
A
A
D
L
V
K
R
L
D
V
L
L
H
L
G
L
G
Y
L
G
L
D
R
S
T
P
T
L
S
P
G
E
L
Q
R
L
R
L
A
T
Q
L
Y
S
N
L
F
-
G
V
V
Y
V
L
D
E
P
S
A
G
L
H
P
A
D
T
E
A
L
L
S
A
L
E
N
L
K
R
G
G
N
S
L
F
V
V
E
H
D
L
D
V
I
R
-
R
-
A
D
W
L
V
D
V
G
P
E
A
G
E
K
G
G
E
I
L
Y
S
G
P
P
E
G
L
K
H
V
P
---
E
S
Q
T
G
Q
Y
L
F
----
A
D
R
--------
H
T
--
E
--------------
P
H
T
--
P
R
E
P
-
A
G
W
L
E
L
N
G
V
----
T
----
R
----
N
N
L
D
N
L
D
V
R
F
P
L
G
V
M
T
S
V
T
G
V
S
G
S
G
K
S
T
L
V
S
Q
A
L
V
D
A
L
A
A
H
F
GQ
P
V
N
P
D
P
E
D
D
E
D
P
A
D
------
H
T
A
G
-
S
A
R
L
G
G
D
L
A
Q
I
-
T
R
L
V
R
V
D
Q
K
P
I
G
R
T
P
R
S
N
M
A
T
Y
T
G
L
F
D
Q
V
R
K
L
F
A
A
T
P
L
A
K
K
--
R
G
Y
N
A
G
R
F
S
F
N
V
K
G
G
R
C
E
H
C
Q
G
E
G
W
V
M
V
E
-
L
L
------------------------------------------------------------------------------------
F
L
P
----------------------------
S
V
Y
A
P
C
P
V
C
H
G
T
R
Y
N
A
E
T
L
E
V
E
Y
R
G
K
N
I
A
D
V
L
A
L
T
V
D
E
A
H
D
F
F
A
D
E
--------------------------
S
A
I
F
R
A
L
D
T
L
R
E
V
G
L
G
Y
L
R
L
G
Q
P
A
T
E
L
S
G
G
E
A
Q
R
I
K
L
A
T
E
L
R
R
S
G
R
G
G
T
V
Y
V
L
D
E
P
T
T
G
L
H
P
A
D
V
E
R
L
Q
R
Q
L
V
K
L
V
D
-
A
G
N
T
V
I
A
V
E
H
K
M
Q
V
V
-
A
-
A
S
D
W
V
L
D
I
G
P
G
A
G
E
D
G
G
R
L
V
A
Q
G
T
P
A
E
V
A
Q
A
A
----
G
S
V
T
A
P
Y
L
R
A
A
L
R
136
HHSearch
60.28
31%
-80
- C3 -
2VF7
3
?
A:
[13-476]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
F
V
Q
V
R
G
A
----
R
----
Q
----
H
N
L
K
D
I
S
V
K
V
P
R
D
A
L
V
V
F
T
G
V
S
G
S
G
K
S
S
L
A
F
G
T
L
Y
---------
A
E
A
Q
R
R
Y
L
E
S
V
S
P
Y
ARRLFN
Q
A
G
V
-
P
D
V
D
A
--
I
D
G
L
-
P
P
A
V
A
L
Q
Q
A
R
G
T
P
T
A
R
S
S
V
G
S
V
T
T
L
S
N
L
L
R
M
L
Y
S
R
A
G
D
Y
P
P
GQ
G
I
V
Y
A
E
G
F
S
P
N
T
P
E
G
A
C
P
E
C
H
G
L
G
R
V
Y
T
V
T
E
D
SMVPDPSLTIRERAVAAWPQA
W
G
G
Q
N
Q
R
D
I
L
V
T
L
GIDVDVPWRELP
E
E
T
R
H
W
I
L
FTD
E
Q
P
V
V
P
V
Y
P
GLT
P
A
E
T
Q
R
A
L
K
K
KMEPS
Y
M
G
T
F
S
S
A
R
R
H
V
L
H
T
F
A
NTES
A
S
M
K
K
R
V
Q
G
Y
M
I
S
E
E
C
P
L
C
H
G
K
R
L
R
Q
E
A
L
N
V
T
F
A
G
L
D
I
T
E
L
S
R
L
P
L
A
R
V
S
E
L
L
R
P
Y
AEEREPGHAERVKNRPE
Q
A
I
A
L
Q
R
M
A
A
D
L
V
K
R
L
D
V
L
L
H
L
G
L
G
Y
L
G
L
D
R
S
T
P
T
L
S
P
G
E
L
Q
R
L
R
L
A
T
Q
L
Y
S
N
L
-
F
G
V
V
Y
V
L
D
E
P
S
A
G
L
H
P
A
D
T
E
A
L
L
S
A
L
E
N
L
K
R
-
G
G
N
S
L
F
V
V
E
H
D
L
D
V
I
-
R
-
R
A
D
W
L
V
D
V
G
P
E
A
G
E
K
G
G
E
I
L
Y
S
G
P
P
E
G
L
K
H
V
P
E
S
Q
-
T
G
Q
Y
L
F
A
D
R
H
T
E
P
142
HHSearch
56.21
36%
-69
- C3 -
2R6F
3
?
A:
[627-953]
------
G
R
W
L
E
V
V
G
A
R
E
H
N
L
K
N
V
S
V
K
I
P
L
G
T
F
V
A
V
T
G
V
S
G
S
G
K
S
T
L
V
N
E
V
L
Y
K
A
L
A
Q
K
L
H
R
A
-------
K
A
K
P
G
E
H
R
D
I
R
G
L
E
H
L
D
K
V
I
D
I
D
Q
S
P
I
G
R
T
P
R
S
N
P
A
T
Y
T
G
V
F
D
D
I
R
D
V
F
A
S
T
N
E
A
K
----------------------------------------------------------------------------------------------------------------------------------------------
V
R
G
Y
K
K
G
R
F
S
F
N
V
K
G
G
R
C
E
A
C
H
G
D
G
I
I
K
-
I
-
E
M
H
-------------------------------
F
----------------------------------------------------------------------------------------------------------------------------------
L
--
P
D
V
Y
V
P
C
E
V
C
H
G
K
R
Y
N
R
E
T
L
E
V
T
Y
K
G
K
N
I
A
E
V
L
D
M
T
V
E
D
A
L
D
--------
F
F
A
------
S
I
------------------------
P
K
I
K
R
K
L
E
T
L
Y
D
V
G
L
G
Y
M
K
L
G
Q
P
A
T
T
L
S
G
G
E
A
Q
R
V
K
L
A
A
E
L
H
R
R
S
N
G
R
T
L
Y
I
L
D
E
P
T
T
G
L
H
V
D
D
I
A
R
L
L
D
V
L
H
R
L
V
D
N
G
D
T
V
L
V
I
E
H
N
L
D
V
I
K
-
T
-
A
D
Y
I
I
D
L
G
P
E
G
G
D
R
G
G
Q
I
V
A
V
G
T
P
E
E
V
A
E
V
K
E--
S
H
-
T
G
R
Y
L
K
----
P
I
L
--------
E
R
--
D
-------
R
---
A
--
R
M
Q
--
A
R
Y
E
-
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
138
HHSearch
50.70
21%
-44
- C3 -
3J16
2
RLI1_YEAST
B:
[205-560]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
I
K
I
L
Q
L
E
N
-
V
L
K
R
D
I
E
K
L
S
G
G
E
L
Q
R
F
A
I
G
M
S
C
V
Q
E
A
D
---
V
Y
M
F
D
E
P
S
S
Y
L
D
V
K
Q
R
L
N
A
A
Q
I
I
R
S
L
L
A
P
T
K
Y
V
I
C
V
E
H
D
L
S
V
L
D
Y
L
-
S
D
F
V
C
I
I
Y
G
V
P
S
V
Y
-
G
V
V
T
L
P
A
S
V
R
E
G
I
N
I
F
L
D
G
H
I
-
P
A
E
N
L
R
----
F
R
T
E
-------
A
L
Q
F
R
-------
I
---
A
DA
T
E
D
LQ
N
D
S
A
-
S
R
A
F
S
Y
P
S
L
----
K
K
T
QG
D
----
F
V
L
N
V
E
E
G
E
F
S
D
S
E
I
L
V
M
M
G
E
N
G
T
G
K
T
T
L
I
K
L
L
A
G
---------
A
L
-----
K
------------------
P
D
E
G
--
Q
D
I
P
K
L
N
V
S
M
K
P
Q
K
I
A
-------------------
P
K
------------------
F
--
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
G
T
V
R
Q
L
F
F
K
K
I
R
G
Q
---
F
L
N
-----------------------------
P
Q
F
Q
T
D
V
V
K
P
L
R
I
D
D
-
I
I
D
Q
E
V
Q
H
L
S
G
G
E
L
Q
R
V
A
I
V
L
A
L
G
I
P
---
A
D
I
Y
L
I
D
E
P
S
A
Y
L
D
S
E
Q
R
I
I
C
S
K
V
I
R
R
F
I
L
H
N
K
K
T
A
F
I
V
E
H
D
F
I
M
A
-
T
Y
L
A
D
K
V
I
V
F
E
G
----
I
P
S
K
N
A
H
A
R
A
P
E
S
L
L
T
G
C
N
R
F
-
L
K
N
L
N
V
T
F
R
R
D
P
N
140
HHSearch
50.03
23%
-51
- C3 -
1YQT
4
?
A:
[145-477]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
E
L
E
N
-
V
L
E
R
E
I
Q
H
L
S
G
G
E
L
Q
R
V
A
I
A
A
A
L
L
R
N
A
T
---
F
Y
F
F
D
E
P
S
S
Y
L
D
I
R
Q
R
L
N
A
A
R
A
I
R
R
L
S
E
E
G
K
S
V
L
V
V
E
H
D
L
A
V
L
D
-
Y
L
S
D
I
I
H
V
V
Y
G
E
P
G
V
Y
G
I
F
S
Q
P
K
G
T
R
N
G
I
N
------
E
F
-
L
R
G
Y
L
K
----
D
E
N
VRFRP
Y
E
I
K
F
--
T
-------
K
T--
G
--
E
R
V
--
E
I
E
R
-
E
T
L
V
T
Y
P
R
L
----
V
----
K
D
YGS
F
R
L
E
V
E
P
G
E
I
K
K
G
E
V
I
G
I
V
G
P
N
G
I
G
K
T
T
F
V
K
M
L
A
G
---------
V
E
-----------------------
E
P
T
E
G
---------
K
I
E
W
D
L
T
V
-
A
---------
Y
---
K
P
Q
Y
I
K
A
-----------------
D
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
G
T
V
Y
E
L
L
S
K
I
D
--
A
S
K
L
------------------------------
N
S
N
F
Y
K
T
E
L
L
K
P
L
G
I
I
D
-
L
Y
D
R
E
V
N
E
L
S
G
G
E
L
Q
R
V
A
I
A
A
T
L
L
R
D
---
A
D
I
Y
L
L
D
E
P
S
A
Y
L
D
V
E
Q
R
L
A
V
S
R
A
I
R
H
L
M
E
K
N
E
K
T
A
L
V
V
E
H
D
V
L
M
I
-
D
Y
V
S
D
R
L
M
V
F
E
G
E
P
G
K
Y
G
R
A
L
P
P
M
G
M
R
E
G
M
N
R
F
L
A
S
I
-
G
I
T
F
R
R
D
P
D
T
G
R
P
137
HHSearch
48.76
23%
-53
- C3 -
3BK7
2
?
A:
[212-547]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
K
E
L
E
L
E
N
-
V
L
D
R
E
L
H
Q
L
S
G
G
E
L
Q
R
V
A
I
A
A
A
L
L
R
K
A
H
---
F
Y
F
F
D
E
P
S
S
Y
L
D
I
R
Q
R
L
K
V
A
R
V
I
R
R
L
A
N
E
G
K
A
V
L
V
V
E
H
D
L
A
V
L
D
Y
L
-
S
D
V
I
H
V
V
Y
G
E
P
G
V
Y
G
I
F
S
K
P
K
G
T
R
N
G
I
-
N
-----
E
F
-
L
Q
G
Y
L
K
----
D
E
N
VRFRP
Y
--
E
I
--
R
-------
F
TKL
S
--
E
R
V
--
D
V
E
R
-
E
T
L
V
E
Y
P
R
L
----
V
----
K
D
YGS
F
K
L
E
V
E
P
G
E
I
R
K
G
E
V
I
G
I
V
G
P
N
G
I
G
K
T
T
F
V
K
M
L
A
G
---------
V
E
-----------------------
E
P
T
E
G
---------
K
V
E
W
D
L
T
-
V
A
Y
K
P
Q
-----------
Y
I
K
A
E
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
G
T
V
Y
E
L
L
S
K
I
D
S
S
--
K
L
-
N
-----------------------------
S
N
F
Y
K
T
E
L
L
K
P
L
G
I
I
D
L
-
Y
D
R
N
V
E
D
L
S
G
G
E
L
Q
R
V
A
I
A
A
T
L
L
R
D
---
A
D
I
Y
L
L
D
E
P
S
A
Y
L
D
V
E
Q
R
L
A
V
S
R
A
I
R
H
L
M
E
K
N
E
K
T
A
L
V
V
E
H
D
V
L
M
I
-
D
Y
V
S
D
R
L
I
V
F
E
G
E
P
G
R
H
G
R
A
L
P
P
M
G
M
R
E
G
M
N
R
F
L
A
S
V
-
G
I
T
F
R
R
D
P
D
S
G
R
P
139
HHSearch
47.85
22%
-56
- C3 -
3OZX
5
?
A:
[123-460]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
L
L
N
M
T
N
L
-
W
N
K
D
A
N
I
L
S
G
G
G
L
Q
R
L
L
V
A
A
S
L
L
R
E
A
D
---
V
Y
I
F
D
Q
P
S
S
Y
L
D
V
R
E
R
M
N
M
A
K
A
I
R
E
L
L
K
-
N
K
Y
V
I
V
V
D
H
D
L
I
V
L
D
Y
L
-
T
D
L
I
H
I
I
-------
Y
G
E
S
S
V
Y
G
R
V
S
K
S
Y
A
A
R
---
V
G
-
I
N
N
F
L
K
GYLP
A
E
N
M-------
K
I
--
R
PDEIKFM
L
---
K
----------
L
-
K
T
K
M
K
W
T
K
I
I
K
K
L
G
----
D
----
F
Q
L
V
V
D
N
G
E
A
K
E
G
E
I
I
G
I
L
G
P
N
G
I
G
K
T
T
F
A
R
I
L
V
G
---------
E
I
-----------------------
T
A
D
E
G
---------
S
V
T
P
E
K
Q
I
L
S
Y
K
P
Q
R
I
--------------
F
-----------------
P
N
Y
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
D
G
T
V
Q
Q
Y
L
E
N
A
S
K
D
A
L
---
S
----------------------------
T
S
S
W
F
F
E
E
V
T
K
R
L
N
L
H
R
-
L
L
E
S
N
V
N
D
L
S
G
G
E
L
Q
K
L
Y
I
A
A
T
L
A
K
E
---
A
D
L
Y
V
L
D
Q
P
S
S
Y
L
D
V
E
E
R
Y
I
V
A
K
A
I
K
R
V
T
R
E
R
K
A
V
T
F
I
I
D
H
D
L
S
I
H
-
D
Y
I
A
D
R
I
I
V
F
K
G
E
P
E
K
A
G
L
A
T
S
P
V
T
L
K
T
G
M
N
E
F
L
R
E
L
-
E
V
T
F
R
R
D
A
E
T
G
R
P
147
HHSearch
44.19
21%
-19
- C1 -
1V43
-
?
A:
[124-243]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
W
A
A
E
L
L
Q
I
E
E
-
L
L
N
R
Y
P
A
Q
L
S
G
G
Q
R
Q
R
V
A
V
A
R
A
I
V
V
E
---
P
D
V
L
L
M
D
E
P
L
S
N
L
D
A
K
L
R
V
A
M
R
A
E
I
K
K
L
Q
Q
K
L
K
V
T
T
I
Y
V
T
H
D
Q
V
E
A
M
T
-
M
G
D
R
I
A
V
M
------
N
R
G
Q
L
L
Q
I
G
S
P
T
E
V
Y
L
R
---
P
N
S
V
F
V
A
T
F
I
G
A
P
E
M