@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_0670: (2015-12-17 )
MRAKMKDIYLDVEKSIKDLQSIFKNADGRDEKLKRFNQEALEVFQKLERESLKELESLKNNEEWENFTIAFYGETGAGKSTLIECLRMFFKEQSKVDQQERFKRLYSTYQYNHQNFILLDVPGIEGSEKKVIDQISNATQKAHAIFMLPKRLILRKKEKKGKGERLKKSKNSLIRKQRYGRFSTNRLIAQEP
Atome Classification :
(20 SA)
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------.......---..10........20........30....-.-.-----..40........50--....------.--------....60-..-.......70........80........90-..------..-.---...----100-----....--.....110.......120-----.-..---..---.---.---.-------.---130--.........140...--....150.......160..-......170.......180.----------......190------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MRAK
M
K
D
---
I
Y
L
D
V
E
K
S
I
K
D
L
Q
S
I
F
KNADG
R
D
E
K
L
K
R
-
F
-
N
-----
Q
E
A
L
E
V
F
Q
K
L
E
R
E
---
S
L
K
E
------
L
--------
E
S
L
KN--NE-EWE
N
F
T
I
A
F
YGETGA
G
K
S
T
L
I
E
C
L
R
M
F
F
K
-
E
Q
------SK-V---
D
Q
Q
----
E
-------
R
F
K
R
--
L
Y
S
T
YQYNHQ
N
F
I
L
L
D-------V-PG---IE---G---
S
---
E
-------
K
---
K
----
V
I
D
Q
I
SN
A
T
Q
K
A
H
A
I
--
F
M
L
P
K
R
L
I
L
R
K
K
EKK-GK
G
-
E
R
L
K
K
S
K
N
S
L
I
R
K
Q
RYGRFS----------TNRLIAQEP------------------------------------------------------------------------------------------------------------------------------------------
63
HHSearch
67.78
21%
7
- C1 -
3WMG
1
?
A:
[305-519]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
Q
---
V
W
P
D
V
T
R
G
L
G
A
G
G
E
L
F
A
M
I
D
R
V
P
Q
Y
R
R
P
-
D
-
P
G
A
E
V
V
T
Q
P
L
V
L
K
Q
G
I
V
F
E
---
N
V
H
F
------
R
Y
PTRMNV-
E
V
L
R
G
I
S
L
T
-
I
P
N
G
K
T
V
A
I
V
G
G
S
G
A
G
K
S
T
I
I
Q
L
L
M
R
F
Y
D
-
I
E
PQG---
G
G
L
L
L
F
-
D
G
T
PAWN
Y
-------
D
F
H
A
--
L
R
S
Q
I
G
L
V
S
Q
E
P
V
L
F
S
-------
G
-
T
I
R
D
N
I
L
Y
--
G
---
K
---
R
-------
D
---
A
----
T
D
E
E
V
I
Q
A
L
R
E
A
N
A
Y
--
S
F
V
M
A
L
P
D
G
L
D
T
E
V
G
-
E
R
G
-
L
A
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
I
L
K
H
----------
P
T
L
L
C
L
D
E
S
------------------------------------------------------------------------------------------------------------------------------------------
61
HHSearch
65.79
20%
19
- C1 -
3B60
2
MSBA_SALTY
A:
[300-507]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
T
N
---
V
N
A
Q
F
Q
R
G
M
A
A
C
Q
T
L
F
A
I
L
D
S
E
Q
E
K
D
E
G
-
K
-
R
------
V
I
D
R
A
T
G
D
L
E
F
R
---
N
V
T
F
------
T
Y
PGREV--
P
A
L
R
N
I
N
L
K
-
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
-
I
D
------
E
G
H
I
L
M-
D
G
H
DLRE
Y
-------
T
L
A
S
--
L
R
N
Q
V
A
L
V
S
Q
N
V
H
L
F
N
-------
D
-
T
V
A
N
N
I
A
---
Y
---
A
---
R
TE-----
E
---
Y
----
S
R
E
Q
I
E
E
A
A
R
M
A
Y
A
M
--
D
F
I
N
K
M
D
N
G
L
D
T
I
I
G
-
E
N
G
-
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
----------
S
P
I
L
I
L
D
E
A
------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
64.18
28%
-103
- C2 -
4DCT
1
DER_BACSU
A:
[181-253]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
---
H
F
K
N
------
I
--------
P
E
T
K
Y
--
N
E
-
E
V
I
Q
F
C
L
--
I
G
R
P
N
V
G
K
S
S
L
V
N
A
--
M
L
G
E
-
E
R
------
V
I
-
V
---
S
N
-----------------DA
V
D
T
S
F
T
Y
N
Q
Q
E
F
V
I
V
D
-------
T
-
A
G
---
M
R
---
K
---
K
---
G
-------
K
---
V
----
Y
E
T
T
E
K
Y
S
V
L
R
A
L
K
A
--
I
D
R
S
E
V
V
A
V
V
L
D
G
E
E
-
G
I
I
-
E
Q
D
K
R
I
A
G
Y
A
H
E
A
G
K
A
V
V
I
V
----------
V
N
K
W
D
A
V
D
K
------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
63.95
28%
-97
- C2 -
4DCU
1
DER_BACSU
A:
[181-253]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
---
H
F
K
N
------
I
--------
P
E
T
K
Y
--
N
E
-
E
V
I
Q
F
C
L
--
I
G
R
P
N
V
G
K
S
S
L
V
N
A
--
M
L
G
E
-
E
R
------
V
I
-
V
---
S
N
-----------------DA
V
D
T
S
F
T
Y
N
Q
Q
E
F
V
I
V
D
-------
T
-
A
G
---
M
R
---
K
---
K
---
G
-------
K
---
V
----
Y
E
T
T
E
K
Y
S
V
L
R
A
L
K
A
--
I
D
R
S
E
V
V
A
V
V
L
D
G
E
E
-
G
I
I
-
E
Q
D
K
R
I
A
G
Y
A
H
E
A
G
K
A
V
V
I
V
----------
V
N
K
W
D
A
V
D
K
------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
63.91
28%
-106
- C2 -
4DCS
1
DER_BACSU
A:
[181-253]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
---
H
F
K
N
------
I
--------
P
E
T
K
Y
--
N
E
-
E
V
I
Q
F
C
L
--
I
G
R
P
N
V
G
K
S
S
L
V
N
A
--
M
L
G
E
-
E
R
------
V
I
-
V
---
S
N
-----------------DA
V
D
T
S
F
T
Y
N
Q
Q
E
F
V
I
V
D
-------
T
-
A
G
---
M
R
---
K
---
K
---
G
-------
K
---
V
----
Y
E
T
T
E
K
Y
S
V
L
R
A
L
K
A
--
I
D
R
S
E
V
V
A
V
V
L
D
G
E
E
-
G
I
I
-
E
Q
D
K
R
I
A
G
Y
A
H
E
A
G
K
A
V
V
I
V
----------
V
N
K
W
D
A
V
D
K
------------------------------------------------------------------------------------------------------------------------------------------
50
Fugue
63.63
15%
-29
- C1 -
1MKY
6
DER_THEMA
A:
[2-439]
-------------------------------------------------------------------------------------A
T
V
L
I
V
G
R
P
NVG
K
S
T
L
F
N
K
L
V
KDPV
Q
D
T
V
E
W
YG
K
T
F
K
L
V
DTCGVFDNPQDIIS
Q
K
M
K
E
V
T
L
N
M
I
R
EADLVL
F
V
V
D
GKRGIT
K
E
D
E
S
L
A
D
F
L
R
K
S
T
V
D
T
I
L
V
A
N
KAEN
L
R
E
F
E
R
E
---
V
K
P
E
L
Y
S
L
--
G
F
G
E
P
I
P
V
S
A
E
H
N
I
N
L
D
T
M
L
-
E
-----
T
I
I
K
K
L
E
E
K
G
L
D
L
---
E
---------------------
S
K
--
P
E
-
I
T
D
A
I
K
V
A
I
V
G
R
P
N
V
G
K
S
T
L
F
N
A
I
L
N
--
K
-
E
R
------
A
L
-
V
---
S
P
I
----
P
-------
V
------
D
D
E
V
F
I
D
G
R
K
Y
V
F
V
D
-------
T
-
A
G
---
L
E
---
K
Y--
S
---
N
-------
Y
---
R
----
V
V
D
S
I
E
K
A
D
---
V
V
V
--
I
V
L
D
A
T
Q
G
I
T
R
Q
D
Q
R
M
A
G
L
M
E
R
R
G
R
A
S
V
V
V
F
N
K
W
D
L
V
V
H
R
----------
E
K
R
Y
D
E
F
T
K
L
F
R
E
K
L
YFIDY
S
P
L
I
F
T
S
ADKGWN
I
D
R
M
I
D
A
M
N
L
A
Y
A
S
Y
T
T
K
V
P
S
S
A
I
N
S
A
L
Q
K
V
L
A
F
T
N
L
P
RGLKIF
F
G
V
Q
VDIKPP
T
F
L
F
F
V
NSIEKVK
N
P
Q
K
I
F
L
R
K
L
I
R
D
YVFPFEG
S
P
I
F
L
K
F
K
R
S
R----------------
16
PsiBlast_PDB
63.09
28%
-94
- C2 -
4DCV
1
DER_BACSU
A:
[181-253]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
---
H
F
K
N
------
I
--------
P
E
T
K
Y
--
N
E
-
E
V
I
Q
F
C
L
--
I
G
R
P
N
V
G
K
S
S
L
V
N
A
--
M
L
G
E
-
E
R
------
V
I
-
V
---
S
N
-----------------DA
V
D
T
S
F
T
Y
N
Q
Q
E
F
V
I
V
D
-------
T
-
A
G
---
M
R
---
K
---
K
---
G
-------
K
---
V
----
Y
E
T
T
E
K
Y
S
V
L
R
A
L
K
A
--
I
D
R
S
E
V
V
A
V
V
L
D
G
E
E
-
G
I
I
-
E
Q
D
K
R
I
A
G
Y
A
H
E
A
G
K
A
V
V
I
V
----------
V
N
K
W
D
A
V
D
K
------------------------------------------------------------------------------------------------------------------------------------------
62
HHSearch
61.46
16%
21
- C1 -
3ZDQ
1
ABCBA_HUMAN
A:
[297-510]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
S
S
---
F
Y
S
E
L
M
K
G
L
G
A
G
G
R
L
W
E
L
L
E
R
E
P
K
L
P
F
N
-
E
-
G
V
I
---
L
N
E
K
S
F
Q
G
A
L
E
F
K
---
N
V
H
F
------
A
Y
PARPEV-
P
I
F
Q
D
F
S
L
S
-
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
-
P
A
------
S
G
T
I
S
L
-
D
G
H
DIRQ
L
-------
N
P
V
W
--
L
R
S
K
I
G
T
V
S
Q
E
P
I
L
F
S
-------
C
-
S
I
A
E
N
I
A
---
Y
---
G
---
A
D------
D
PSS
V
----
T
A
E
E
I
Q
R
V
A
E
V
A
N
A
V
--
A
F
I
R
N
F
P
Q
G
F
N
T
V
V
G
-
E
K
G
-
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
----------
P
K
I
L
L
L
D
E
A
------------------------------------------------------------------------------------------------------------------------------------------
60
HHSearch
58.61
19%
246
- C- -
3B5X
-
MSBA_VIBCH
A:
[300-507]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
T
S
---
V
T
S
E
F
Q
R
G
M
A
A
C
Q
T
L
F
G
L
M
D
L
E
T
E
R
D
N
G
-
K
-------
Y
E
A
E
R
V
N
G
E
V
D
V
K
---
D
V
T
F
T
Y
QGKE
K
--------
P
A
L
S
H
V
S
F
S
-
I
P
Q
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
N
L
F
T
R
F
Y
D
-
V
D
------
S
G
S
I
C
L
-
D
G
H
DVRD
Y
-------
K
L
T
N
--
L
R
R
H
F
A
L
V
S
Q
N
V
H
L
F
N
-------
D
-
T
I
A
N
N
I
A
---
Y
---
A
---
A
EG-----
E
---
Y
----
T
R
E
Q
I
E
Q
A
A
R
Q
A
H
A
M
--
E
F
I
E
N
M
P
Q
G
L
D
T
V
I
G
-
E
N
G
-
T
S
L
S
G
G
Q
R
Q
R
V
A
I
A
R
A
L
L
R
D
----------
A
P
V
L
I
L
D
E
A
------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
57.26
31%
-56
- C2 -
5DGX
1
?
A:
[46-132]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
A
F
V
G
K
S
G
S
G
K
T
T
L
T
S
I
I
S
R
F
Y
T
-
Q
H
E
G
E
I
L
L
D
G
-
V
---
D
T
R
----
E
L------
T
L
E
N
--
L
R
S
H
L
S
I
V
S
Q
N
V
H
L
F
D
DT
V
Y
N
N
I
A
-
F
G
----
E
---
V
---
S
---
E
-------
E
---
E
----
V
I
D
A
L
K
R
A
N
A
Y
E
F
V
Q
--
E
L
S
D
G
I
N
T
N
I
G
N
N
G
S
-
K
L
S
-
G
G
Q
R
Q
R
I
S
I
A
R
A
L
L
K
N
A
P
V
L
----------
I
F
D
E
L
E
S
L
T
------------------------------------------------------------------------------------------------------------------------------------------
65
HHSearch
56.64
18%
27
- C1 -
3NH6
2
A:
[19-217]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
H
M
F
I
D
M
E
N
M
F
D
L
L
K
E
E
T
E
V
K
D
L
-
P
G
A
-----
G
P
L
R
F
Q
K
G
R
I
E
F
E
---
N
V
H
F
------
S
YADGR---
E
T
L
Q
D
V
S
F
T
-
V
M
P
G
Q
T
L
A
L
V
G
P
S
G
A
G
K
S
T
I
L
R
L
L
F
R
F
Y
D
-
I
S
------
S
G
C
I
R
I
-
D
G
Q
----
D
ISQV---
T
Q
A
S
--
L
R
S
H
I
G
V
V
P
Q
D
T
V
L
F
N
-------
D
-
T
I
---
A
D
N
I
R
Y
---
G
---
R
V------
T
---
A
----
G
N
D
E
V
E
A
A
A
Q
A
A
G
I
H
--
D
A
I
M
A
F
P
E
G
Y
R
T
Q
V
G
-
E
R
G
-
L
K
L
S
G
G
E
K
Q
R
V
A
I
A
R
T
I
L
K
A
----------
P
G
I
I
L
L
D
E
A
------------------------------------------------------------------------------------------------------------------------------------------
67
HHSearch
55.09
15%
20
- C1 -
2IXE
4
TAP1_RAT
A:
[13-183]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
G
L
V
K
F
Q
---
D
V
S
F
------
A
YPNHPNV-
Q
V
L
Q
G
L
T
F
T
-
L
Y
P
G
K
V
T
A
L
V
G
P
N
G
S
G
K
S
T
V
A
A
L
L
Q
N
L
Y
Q
-
P
T
------
G
G
K
V
L
L
-
D
G
E
PLVQ
Y
-------
D
H
H
Y
--
L
H
T
Q
V
A
A
V
G
Q
E
P
L
L
F
G
-------
R
-
S
F
---
R
E
---
N
---
I
A
YG
L
T
R
-----
T
---
P
----
T
M
E
E
I
T
A
V
A
M
E
S
G
A
H
--
D
F
I
S
G
F
P
Q
G
Y
D
T
E
V
G
-
E
T
G
-
N
Q
L
S
G
G
Q
R
Q
A
V
A
L
A
R
A
L
I
R
K
----------
P
R
L
L
I
L
D
N
A
------------------------------------------------------------------------------------------------------------------------------------------
75
HHSearch
54.52
19%
13
- C1 -
1MV5
2
LMRA_LACLA
A:
[23-166]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
-
A
Q
P
N
S
I
I
A
F
A
G
P
S
G
G
G
K
S
T
I
F
S
L
L
E
R
F
Y
Q
-
P
T
------
A
G
E
I
T
I
-
D
G
Q
PIDN
I
-------
S
L
E
N
--
W
R
S
Q
I
G
F
V
S
Q
D
S
A
I
M
A
-------
G
-
T
I
---
R
E
---
N
L
T
Y
G
---
L
EG-----
D
---
Y
----
T
D
E
D
L
W
Q
V
L
D
L
A
F
A
R
--
S
F
V
E
N
M
P
D
Q
L
N
T
E
V
G
-
E
R
G
-
V
K
I
S
G
G
Q
R
Q
R
L
A
I
A
R
A
F
L
R
N
----------
P
K
I
L
M
L
D
E
A
------------------------------------------------------------------------------------------------------------------------------------------
76
HHSearch
54.37
16%
18
- C1 -
3TUI
1
METN_ECOLI
C:
[23-190]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
M
I
K
L
S
---
N
I
T
K
------
V
FHQGTRTI
Q
A
L
N
N
VS
L
H
-
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
-
P
T
------
E
G
-
S
VLV
D
G
Q
----
E
LTTLSES
E
L
T
K
--
A
R
R
Q
I
G
M
I
F
Q
H
F
N
L
L
S
-------
S
R
T
V
---
F
G
---
N
VAL
P
---
L
ELD----
N
---
T
PKDE
V
K
R
R
V
T
E
L
L
S
L
V
G
L
G
--
D
K
H
-------
D
-----
S
Y
P
-
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
----------
P
K
V
L
L
C
D
Q
A
------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
54.30
25%
-4
- C1 -
2GZA
1
VIRBB_BRUSU
A:
[135-258]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
G
F
F
K
H
V
R
P
M
S
K
S
L
T
P
-
F
-
E
-----
Q
E
L
L
A
L
-----
K
E
---
A
G
D
Y
------
M
--------
S
F
L
R
R
--
A
V
-
Q
L
E
R
-
V
I
V
V
A
G
E
T
G
S
G
K
T
T
L
M
K
A
L
M
Q
E
I
P
-
F
D
------
Q
R
-
L
---
I
T
I
----
E
-------
D
V
P
E
--
L
F
L
P
---
D
H
P
N
H
V
H
L
F
-------
Y
-
P
--------------------------------------
V
T
A
A
T
L
L
R
S
C
L
--
R
M
K
P
T
R
I
L
L
A
E
L
R
G
G
-
E
A
Y
-
D
F
I
N
V
A
A
S
G
H
G
G
S
I
T
S
C
H
A
G
----------
S
C
E
L
T
F
E
R
L
------------------------------------------------------------------------------------------------------------------------------------------
59
Fugue
52.94
14%
14
- C3 -
4BTB
1
P4HA1_HUMAN
A:
[3-237]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PG
F
F
T
S
I
G
Q
M
T
D
---
L
I
H
T
E
K
D
L
V
T
S
L
K
D
Y
I
K
A
E
E
D
K
L
E
Q
I
K
K
-
W
-
A
-----
E
K
L
D
R
L
T
S
T
A
T
K
D
PGH
P
V
N
A
------
F
--------
K
L
M
K
R
--
L
N
T
E
W
S
E
L
E
N
L
V
L
K
D
M
S
D
G
F
I
S
N
L
T
I
Q
R
Q
Y
F
P
N
D
E
------
D
Q
-
V
---
G
A
A
----
K
-------
A
L
L
R
--
L
Q
D
T
Y
N
L
D
T
D
T
I
S
K
G
N
-------
L
-
P
G
---
V
K
---
H
---
K
---
S
-------
F
---
L
----
T
A
E
D
C
F
E
L
G
K
V
A
Y
T
E
AD
Y
Y
H
T
E
L
W
M
E
Q
A
L
R
Q
L
-
D
E
G
-
E
I
S
T
I
D
K
V
S
V
L
D
Y
L
S
Y
A
V
Y
Q
Q
GD
L
D
K
A
L
L
L
T
K
K
L
L
E
L
D
P
EH
Q
R
A
N
G
N
L
K
Y
F
E
Y
I
M
A-------------------------------------------------------------------------------------------------------------------------
57
Fugue
52.41
14%
5
- C1 -
4IHQ
5
?
A:
[2-513]
S
F
V
E
D
Y
L
T
K
LQ
E
R
P
T
I
I
ENPNILKGSKI
F
N
A
I
Y
R
V
D
DF
V
Y
I
H
I
Q
SIKSEDG
Y
N
Q
Y
N
V
I
E
P
P
RPT
H
D
E
M
E
E
I
E
E
K
F
A
L
S
IGD
K
E
P
P
ED
T
K
E
K
E
K
L
I
R
S
I
L
D
K
I
L
L
RMRLSVP
K
E
Y
V
I
Y
H
F
I
R
D
K
LYTGSL
E
P
L
I
R
DPYIEDISIPGL
G
H
V
Y
I
V
H
KVF
G
P
M
R
T
SIKFEN
Y
E
E
L
D
N
L
I
V
S
L
S
E
K
S
Y
R
P
V
S
HNRP
V
V
D
A
S
L
P
D
G
S
R
V
N
F
V
Y
G
V
D
I
S
R
R
G
S
N
L
T
V
R
K
F
S
R
V
P
----
T
-
S
-----
I
T
Q
L
I
M
F
G
T
L
S
S
M
---
M
A
A
Y
------
I
--------
W
T
M
L
D
--
E
-----
G
M
N
L
F
V
C
G
E
T
A
S
G
K
T
T
T
L
N
A
I
T
A
F
I
P
-
P
N
------
L
K
-
I
---
V
T
I
----
E
-------
D
T
P
E
--
L
----
T
V
P
H
S
N
W
V
A
E
V
-------
T
-
R
E
---
T
G
---
G
---
E
---
G
-------
T
---
I
----
K
L
F
D
L
L
K
A
A
L
R
Q
R
P
N
--
Y
I
L
V
G
A
I
--
R
D
K
E
G
N
-
V
A
F
-
Q
A
M
Q
T
G
H
S
V
M
A
T
F
H
A
A
N
I
T
T
----------
L
I
Q
R
L
T
G
Y
P
IEVPKSYINNLN
I
A
L
F
Q
T
A
L
Y
D
KKG
N
L
I
R
R
VV
E
V
D
E
I
I
DIDPVTN
D
V
V
Y
I
PA
F
T
Y
D
SVQD
K
M
L
F
AGKGSSYLIENK
I
A
V
K
R
GIDRRNI
G
L
L
Y
D
E
L
Q
M
R
S
R
F
L
N
L
L
V
E
K
KIFN
Y
Y
D
V
W
D
Y
I
L
R
A
R
Q
MG
L
E
E
A
I
K
Y
V
SNI
78
HHSearch
52.01
19%
19
- C1 -
2GHI
5
?
A:
[15-182]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
V
N
I
E
F
S
---
D
V
N
F
------
S
Y
PKQTNH-
R
T
L
K
S
I
N
F
F
-
I
P
S
G
T
T
C
A
L
V
G
H
T
G
S
G
K
S
T
I
A
K
L
L
Y
R
F
Y
D
-
A
E
------
G
D
-
I
K
I
-
G
G
K
NVNK
Y
-------
N
R
N
S
--
I
R
S
I
I
G
I
V
P
Q
D
T
I
L
F
N
-------
E
-
T
I
---
K
Y
---
N
I
L
Y
G
K--
L
-------
D
---
A
----
T
D
E
E
V
I
K
A
T
K
S
A
Q
L
Y
--
D
F
I
E
A
L
P
K
K
W
D
T
I
V
G
-
N
K
G
-
M
K
L
S
G
G
E
R
Q
R
I
A
I
A
R
C
L
L
K
D
----------
P
K
I
V
I
F
D
E
A
------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
50.77
32%
-6
- C2 -
4M1M
2
MDR1A_MOUSE
B:
[1037-1087]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
F
N
Y
P
T
R
P
---
S
I
P
V
------
L
--------
Q
G
L
-
S
--
L
E
-
V
K
K
G
Q
T
L
A
L
V
G
S
S
G
C
G
K
S
T
V
V
Q
L
L
E
R
F
Y
D
-
P
M
------
A
G
-
S
---
V
F
L
----
D
-------
G
K
E
I
--
K
Q
L
N
V
Q
W
L
R
A
Q
L
G
I
V
S
-------
Q
-
E
P
---
I
L
---
F
---
D
---
C
-------
S
---
I
----
A
E
N
I
A
Y
G
D
N
S
R
V
V
S
Y
--
E
E
I
V
R
A
A
K
E
A
N
I
H
Q
F
-
I
D
S
-
L
P
D
K
Y
N
T
R
V
G
D
K
G
T
Q
L
S
G
G
Q
----------
K
Q
R
I
A
I
A
R
A
------------------------------------------------------------------------------------------------------------------------------------------
71
HHSearch
50.51
18%
-3
- C1 -
2IT1
-
?
A:
[18-160]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
N
N
I
N
L
K
-
I
K
D
G
E
F
M
A
L
L
G
P
S
G
S
G
K
S
T
L
L
Y
T
I
A
G
I
Y
K
-
P
T
------
S
G
-
K
I
Y
F
D
E
K
----
D
VT-----
E
L
P
P
--
K
D
R
N
V
G
L
V
F
Q
N
W
A
L
Y
P
-------
H
M
T
V
---
Y
K
---
N
I
A
F
P
---
L
E
L
R
KAP
R
E
---
E
----
I
D
K
K
V
R
E
V
A
K
M
L
H
I
D
--
K
L
L
N
R
Y
------------
P
-
W
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
V
K
E
----------
P
E
V
L
L
L
D
E
P
------------------------------------------------------------------------------------------------------------------------------------------