@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_0683: (2015-12-17 )
MRSWMKKKYFTLLLQSSVVLAVFIGCSSTRNHTFSALSNQENTDDKLPVVHSIKTINDVSSVGFEWSKVADTYDIDGFVLYRLKKDSKLKRIATIKNPYATHYYDEGLETESSYTYQLATYKGDKISKLSEPILVKTSFINPVESVFASLEYPKSVKVFWSPHPNPSVSKYIIQRQNKDGKFLNVGAVKNRLFVEFFDKDLEDGQKYRYQIIAENFMGDKSRPSVIVEGKTKDLPKEIANVRVSQNLTRQIELSWDKSPEEDVIAYRIYASNNRNDKYKFIAQTTNTSYVDKIEKDNLTRYYKVVAVDKTHLEGALPKEPAMGETSDRPEAPIITKGTIQDSSALIQWENNPSPKIATYAVYRFEANSKTPLRFGNITQNQFVDKDMKVGVAYRYQVVSVDKDGLESHPSKEVRLFLER
Atome Classification :
(20 SA)
.........10........20........30........40........50......-..60......--..70-.--........80.....---------------...90...------------.--------....100....-...110.......120-----.....---..130.....---..140........----150-........160-...----.----.-----..--.170.....-.-.-180.-----...-....---.-190......---.200.......210.....-----.----.--220.......230----------------------------------------------------------------------------------.--...-..-..240..----....-.250.......----260.----.-----......-.270--.----.....--------.-----.-.-280---.----.----.--.....290--.......300---........310.......-.320.....---...330......-.-340---.........--350.----.--....----.360..----....-.-----370.--.----.----.---.--------------....380...-....390.......400------.----.-.....410.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
R
S
W
M
K
K
K
Y
F
T
L
L
L
QS
S
V
V
L
A
V
F
IGCSSTRN
H
T
F
SALSNQENTDDKL
P
V
V
H
S
IKTIN-
D
V
S
S
VGFEWS--KVA--D--TYDID
G
F
V
L
Y
R
LKKD---------------SK
L
K
R
I
A
T------------I--------KNPYA
T
H
Y
Y
DE-GLETES
S
Y
T
Y
Q
L
A
TYK-----GD
K
I
S
---KLSE
P
I
L
V
K
T---SFI
N
-
P
V
E
S
V
F
A
S----LE--YP
K
S
V
K
V
F
WS--PHP----N----P-----
S
V
--
S
K
Y
I
I
Q
RQN-K-D-G--
K
-----
F
L
N
-
V
G
A
V---K-
N
R
L
F
V
E
F
F
D
---KDLEDG
Q
K
Y
R
Y
Q
I
I
A
E
N
FM-----G----D--KSR
P
S
V
I
V
EGKT-----------------------------------------------------------------------------------K--
D
L
P
-
K
E
-
I
A
N
V
RVS----QNL
T
-
R
Q
I
E
L
SWDKSP----E--E----
D
-----
V
I
A
Y
R
I
-
Y
A----S----NNRND--------
K
-----
Y
-
K
-
F
-
I
---
A
----Q----T--TN
T
S
Y
V
D
K--IEKDNL
T
R
Y
----
Y
K
V
V
A
V
DKT-HLEGALPK-EP-AMGETS---DRPEA
P
I
I
T
K
G
T-I-Q-----DS
S
A
L
I
Q
WE--NNPS----P--
K
I
A
T
----
Y
A
V
Y
R
F
----EANS-K-----T--P--
L
----
R
----F---G--------------NITQNQFVDK-DM
K
V
G
V
A
Y
R
Y
Q
V
V
S
VDK------D----G-LESHPSK
E
V
R
L
F
LER
13
HHSearch
83.71
16%
-23
- C2 -
1FNF
-
FINC_HUMAN
A:
[1145-1500]
----------------------------------------------
P
P
T
N
L
H
L
E
A
N
P
-
D
T
G
V
L
T
V
S
W
E
--
R
S
T
--
T
--
P
-
D
I
T
G
Y
R
I
T
T
T
P
T
N
G--------------
Q
Q
G
N
S
L
E
E
------------
V
--------
V
H
A
D
Q
S
S
C
T
F
D
-
N
L
S
P
G
L
E
Y
N
V
S
V
Y
T
V
K
-----
D
D
K
E
S
---
V
P
I
S
D
T
I
-
I
----
P
A
V
P
-
P
P
T
D
L
R
F
T
----
N
I
--
G
P
D
T
M
R
V
T
W
A
--
P
P
P
----
S
----
I
-----
D
L
--
T
N
F
L
V
R
Y
S
P
V
K
-
N
E
E
--
D
-----
V
A
E
-
L
-
S
I
-----
S
P
S
D
N
A
V
V
L
---
T
N
L
L
P
G
T
E
Y
V
V
S
V
S
S
V
Y
E
Q
-----
H
-------
E
S
T
P
L
R
---
G
R
Q
-----------------------------------------------------------------------------------
K
--
T
G
L
-
D
S
-
P
T
G
I
D
F
S
----
D
I
T
A
-
N
S
F
T
V
H
W
I
A
P
R
-------
A
----
T
-----
I
T
G
Y
R
I
-
R
H
----
H
----
P
E
H
F
S
--------
G
R----
P
R
E
-
D
-
R
---
V
----
P
----
H
--
S
R
N
S
I
T
L
T
--
N
L
T
P
G
T
E
Y
V
----
V
S
I
V
A
L
N
G
R
-
E
E
-
S
P
L
-
L
-
I
----
G
Q
Q
S
---
T
V
S
D
V
P
R
D
L
E
V
V
-
A
A
T
-----
P
T
S
L
L
I
S
W
D
--
A
P
A
-----
V
--
T
V
R
Y
----
Y
R
I
T
Y
G
----
E
T
G
G
-
N
-----
S
P
V
Q
--
E
----
F
----
T
---
V
--------------
P
G
S
K
S
T
A
T
I
S
-
G
L
K
P
G
V
D
Y
T
I
T
V
Y
A
V
T
G
------
R
----
G
-
D
-
S
P
A
S
S
--------
23
HHSearch
81.01
14%
-23
- C2 -
3L5H
7
IL6RB_HUMAN
A:
[102-481]
-------------------------------------------
P
P
E
K
P
K
N
L
S
C
I
V
N
--
E
G
K
K
M
R
C
E
W
D
--
G
G
R
--
E
--
T
H
L
E
T
N
F
T
L
K
S
E
W
A
T
---------------
H
K
F
A
D
C
K
A
------------
K
--------
R
D
-
T
P
T
S
C
T
V
D
Y
S
T
V
Y
F
V
N
I
E
V
W
V
E
A
E
N
-----
A
L
G
K
V
---
T
-
S
D
H
I
N
F
D
P
VYK
V
K
P
N
-
P
P
H
N
L
S
V
I
----
N
S
EE
L
S
S
I
L
K
L
T
W
T
--
N
P
S
----
I
KS--
V
-----
I
I
--
L
K
Y
N
I
Q
Y
R
T
K
D
-
A
-
S
--
T
-----
W
S
Q
-
I
P
P
E
D--
T
-
A
S
T
R
S
S
F
T
V
---
Q
D
L
K
P
F
T
E
Y
V
F
R
I
R
C
M
K
E
D
-----
G
----
K
G
Y
W
S
D
W
S
E
E
A
S
G
I
T
-----------------------------------------------------------------------------------
Y
E-
D
R
P
-
S
K
A
P
S
F
W
Y
K
I
D
PSH
T
Q
G
Y
-
R
T
V
Q
L
V
W
K
T
L
P
PFEA
N
--
G
----
K
-----
I
L
D
Y
E
V
-
T
L
----
T
----
R
W
K
S
H
--------
L
-------
Q
-
N
-
Y
--------
T
----
V
--
N
A
T
K
L
T
V
---
N
-
L
T
N
D
R
Y
L
----
A
T
L
T
V
R
N
L
V
-
G
K
S
D
-
A
A
V
-
L
T
-
I
P
A
C
D
F
---
Q
A
T
H
P
V
M
D
L
K
A
F
-
P
-
K
-----
D
N
M
L
W
V
E
W
T
--
T
P
R
-----
E
--
S
V
K
K
----
Y
I
L
E
W
C
----
V
L
S
D
-
K
A
P
C
I
T
D
--
W
--
Q
----
Q
----
E
---
D
--------------
G
T
V
H
R
T
Y
L
R
G
-
N
L
A
E
S
K
C
Y
L
I
T
V
T
P
V
Y
A
------
D
----
G
-
P
G
S
P
E
S
I
K
A
Y
L
K
Q
A
P
11
HHSearch
75.37
14%
-7
- C2 -
3T1W
-
FINC_HUMAN
A:
[1187-1530]
----------------------------------------------------------
D
T
G
V
L
T
V
S
W
E
--
R
S
T
--
T
--
P
-
D
I
T
G
Y
R
I
T
T
T
P
T
N
G--------------
Q
Q
G
N
S
L
E
E
------------
V
--------
V
H
A
D
Q
S
S
C
T
F
D
-
N
L
S
P
G
L
E
Y
N
V
S
V
Y
T
V
K
-----
D
D
K
E
S
---
V
P
I
S
D
T
-
I
I
P
----
E
V
P
-
Q
L
T
D
L
S
F
V
----
D
I
--
T
D
S
S
I
G
L
R
W
T
--
P
L
N
----
S
----
S
-----
T
I
--
I
G
Y
R
I
T
V
V
A
-
A
-
G
-
E
--
G
-----
I
P
I
-
F
E
D
F
---
V
-
D
S
S
V
G
Y
Y
T
V
---
T
G
L
E
P
G
I
D
Y
D
I
S
V
I
T
L
I
N
G
-----
G
-------
E
S
A
P
T
---
T
L
T
Q
-----------------------------------------------------------------------------------
Q
--
T
A
V
-
P
P
-
P
T
D
L
R
F
T
----
N
I
G
P
-
D
T
M
R
V
T
W
A
P
P
P
----
S
--
I
----
D
-----
L
T
N
F
L
V
-
R
Y
----
S
----
P
V
K
N
E
E-------
D
-----
V
-
A
E
L
-
S
---
I
----
S
----
P
--
S
D
N
A
V
V
L
T
--
N
L
L
P
G
T
E
Y
V
----
V
S
V
S
S
V
Y
E
Q
-
H
E
S
T
P
L
-
R
------
G
R
Q
K
---
T
G
L
D
S
P
T
G
I
D
F
S
-
D
I
T
-----
A
N
S
F
T
V
H
W
I
--
A
P
R
-----
A
--
T
I
T
G
----
Y
R
I
R
H
H
----
P
E
H
F
S
G
R
----
P
--
R
--
E
----
D
----
R
---
V
--------------
P
H
S
R
N
S
I
T
L
T
-
N
L
T
P
G
T
E
Y
V
V
S
I
V
A
L
N
G
------
R
----
E
--
E
S
P
L
----------
14
HHSearch
71.72
13%
-34
- C2 -
3L5H
6
IL6RB_HUMAN
A:
[198-589]
-------------------------------------------
K
P
N
P
P
H
N
L
S
V
I
N
S
E
E
L
S
S
I
L
K
L
T
W
T
--
N
P
S
--
I
K-
S
V
I
I
L
K
Y
N
I
Q
Y
R
T
K
D
A--------------
S
T
W
S
Q
I
P
P
E-----------
D
--------
T
A
S
T
R
S
S
F
T
V
Q
-
D
L
K
P
F
T
E
Y
V
F
R
I
R
C
M
K
-----
E
D
G
K
G
Y
W
S
D
W
S
E
E
A
S
G
I
T
YE-
D
R
P
S
K
A
P
S
F
W
Y
K
I
D
PSH
T
Q
--
G
Y
R
T
V
Q
L
V
W
K
--
T
L
P
PFEA
N
----
G
-----
K
I
--
L
D
Y
E
V
T
L
T
R
-
W
-
K
-
S
--
H
-----
L
Q
N
-
Y
-
T
-------
V
N
A
T
K
L
T
V
----
N
L
-
T
N
D
R
Y
L
A
T
L
T
V
R
N
L
V
-----
G
----
K
---
S
D
A
A
V
-
L
T
I
P
A
CD---------------------------------------------------------------------------------
F
--
Q
A
T
-
H
P
-
V
M
D
L
K
A
F
----
P
-
K
D
-
N
M
L
W
V
E
W
T
T
P
R
-------
E
----
S
-----
V
K
K
Y
I
L
-
E
W
----
C
----
V
L
S
D
K
A
P
C
I
T
---
D
-----
W
-
Q
-
Q
-
E
---
D
----
G
----
T
--
V
H
R
T
Y
L
R
G
--
N
L
A
E
S
K
C
Y
L
----
I
T
V
T
P
V
Y
A
D
-
G
P
G
S
P
E
-
S
-
I
K
-
A
Y
L
-
K
Q
---
A
P
P
S
K
G
P
T
V
R
T
K
K
V
-
G
-----
K
N
E
A
V
L
E
W
D
--
Q
L
P
V
DVQN
G
--
F
I
R
N
----
Y
T
I
F
Y
R
----
T
I
I
G
-
N
-----
E
--
T
--
A
----
V
----
N
---
V
--------------
D
S
S
H
T
E
Y
T
L
S
-
S
L
T
S
D
T
L
Y
M
V
R
M
A
A
Y
T
D
------
E
----
G
---
G
K
D
G
P
E
F
T
F
T
T
P
K
27
HHSearch
68.57
17%
-41
- C2 -
3L5I
20
A:
[22-277]
-----------------------------------------------------------
Y
R
T
V
Q
L
V
W
K
TL
P
P
F
E-
A
--
N
G
K
I
L
D
Y
E
V
T
L
T
R
W
K
---------------
S
H
L
Q
N
Y
T
------------------------
V
N
A
T
K
L
T
V
N
--
L
-
T
N
D
R
Y
L
A
T
L
T
V
R
N
-----
L
V
G
K
S
---
D
A
A
V
L
T
I
P
A
C
D
F
-
Q
A
T
H
-
P
V
M
D
L
K
A
F
----
P
K
--
D
-
N
M
L
W
V
E
W
T
--
T
P
R
----
E
----------
S
V
--
K
K
Y
I
L
E
W
C
V
L
S
-
D
-
K
--
A
PC
I
T
D
W
Q
Q
-
E
------
D
-
G
T
V
H
R
T
Y
L
R
---
G
N
L
A
E
S
K
C
Y
L
I
T
V
T
P
V
Y
A
D
-----
G
----
P
--
G
-
S
P
E
S
I
K
A
Y
L
K
-----------------------------------------------------------------------------------
Q
--
A
P
P
-
S
K
-
G
P
T
V
R
T
K
----
K
V
G
K
-
N
E
A
V
L
E
W
D
Q
L
P
VDVQ
N
--
G
----
F
-----
I
R
N
Y
T
I
-
F
Y
----
R
----
T
I
I
G
N
--------
E
-----
T
-
A
-
V
-
N
---
V
----
D
----
S
--
S
H
T
E
Y
T
L
S
--
S
L
T
S
D
T
L
Y
M
----
V
R
M
A
A
Y
T
D
E
-
G
G
K
D
G
P
E
F
-
T
F
-
T
T
P
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
HHSearch
68.55
16%
-33
- C2 -
3BPO
-
I13R1_HUMAN
C:
[4-312]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
P
-
P
V
T
N
L
S
V
S
----
V
E
--
N
L
C
T
V
I
W
T
W
N
--
P
P
E
----
G
ASS-
N
-----
C
S
--
L
W
Y
F
S
H
F
G
--
Q
-
D
-
K
--
K
-----
I
A
P
-----------
E
T
-
R
R
S
I
E
---
V
P
L
N
E
--
R
I
C
L
Q
V
G
S
Q
C
--------------------
I
L
V
E
K
C
I
S
P
P
E-------------------------------------------------------------------------------
G
---
P
E
-
S
A
-
V
T
E
L
Q
C
I
----
W
H
N
L
-
S
Y
M
K
C
S
W
L
P
G
R
------------
P
-----
D
T
N
Y
T
L
-
Y
Y
----
W
----
H
R
S
L
E
--------
K
-----
I
-
H
-
Q
-
C
---
E
N
I
F
R
E
----
G
--
Q
Y
F
G
C
S
F
D
--
L
T
K
----
H
S
----
V
Q
I
M
V
K
D
N
A
-
G
K
I
K
-
P
S
F
-
N
I
-
V
P
L
T
S
R
---
V
K
P
D
P
P
H
I
K
N
L
S
-
F
-
H
-----
N
D
D
L
Y
V
Q
W
E
--
N
P
Q
N
----
F
IS
R
C
L
F
----
Y
E
V
E
V
N
----
N
--
T
-
E
-----
T
--
H
--
N
----
V
----
F
---
Y
V
QEAKCENPEFERN
V
E
N
T
S
C
F
M
V
P
-
G
V
L
P
D
T
L
N
T
V
R
I
R
V
K
T
N
KLCYED
D
----
K
-
L
W
S
N
W
S
Q
E
M
S
I
G
K
K
R
22
HHSearch
63.52
16%
-40
- C2 -
3S98
1
INAR1_HUMAN
A:
[17-293]
------------------------------------------------------------
D
N
F
I
L
R
W
N
--------------
V
T
F
S
F
D
Y
Q
K
T
G
M--------------
D
N
W
I
K
L
S
G
------------
C
--------
Q
N
I
T
S
T
K
C
N
F
S
-
S
-
N
V
Y
E
E
I
K
L
R
I
R
A
E
K
-----
E
-
N
T
S
---
S
W
Y
E
V
D
S
F
T
P
FRK
A
Q
I
G
-
P
P
-
E
V
H
L
E
----
A
E
---
D
K
A
I
V
I
H
I
S
--
P
G
-----------SVMW--
S
--
F
T
Y
S
L
V
I
W
K
N
S
-
S
-
G
--
V
-----
E
E
R
-
I
E
--------
N
I
Y
S
R
H
K
I
---
Y
K
L
S
P
E
T
T
Y
C
L
K
V
K
A
A
L
L
T
S----
W
----
K
--
I
G
V
Y
S
P
V
H
C
I
K
T
-----------------------------------------------------------------------------------
T
V
E
N
E
L
-
P
P
-
P
E
N
I
E
V
S
----
V
Q
-
N
-
Q
N
Y
V
L
K
W
D
Y
T
Y
----
A
-------------
N
M
T
F
Q
V
-
Q
W
L
HAF
L
KRNP----
Y
--------
K
-----
W
-
K
-
Q
-
I
PDC
E
----
N
----
V
--
K
T
T
Q
C
V
F
P
Q-
N
V
F
Q
K
G
I
Y
L
----
L
R
V
Q
A
S
D
G
N
-
N
-
T
S
F
W
S
E
-
E
I
-
K
F
D
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
HHSearch
63.22
11%
-20
- C2 -
2DTG
-
INSR_HUMAN
E:
[481-906]
----------------------------------------------------------
S
F
D
K
I
L
L
R
W
E
--
P
Y
W
P
P
D
--
F
R
D
L
L
G
F
M
L
F
Y
K
E
A
P
YQNVT
E
F
D
G
Q
D
A
C
GS
N
S
W
T
V
V
D
I
------------
D
P
P
L
R
S
N
D
P
K
S
Q
N
H
P
G
W
L
M
R
-
G
L
K
P
W
T
Q
Y
A
I
F
V
K
T
L
V
T
F
S
DE
R
R
T
Y
G
---
A
K
S
D
I
I
Y
V
Q
T
D
A
-
T
N
P
S
-
V
P
L
D
P
I
S
V
----
S
N
--
S
S
S
Q
I
I
L
K
W
K
--
P
P
S
----
D
PN--
G
-----
N
I
--
T
H
Y
L
V
F
W
E
R
-
Q
-
A
-
E
--
D
-----
S
E
------------
L
F
E
L
D
Y
C
L
---
K
G
L
K
L
P
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-----
H
-
R
-
P
-
F
E
--
K
----
V
----
V
--
N
K
E
S
L
V
I
S
--
G
L
R
H
F
T
G
Y
R
----
I
E
L
Q
A
C
N
Q
D
-
T
P
E
E
R
C
S
V
A
A
Y
-
V
S
A
R
T
M
P
E
A
K
A
D
D
I
V
G
P
V
T
H
E
-
I
F
E
-----
N
N
V
V
H
L
M
W
Q
--
E
P
K
E
PN--
G
--
L
I
V
L
----
Y
E
V
S
Y
R
----
R
Y
G
D
-
E
-----
E
--
L
--
H
L
C
D
T
R
----
K
---
H
--------------
F
A
L
E
R
G
C
R
L
R
-
G
L
S
P
G
-
N
Y
S
V
R
I
R
A
T
S
L
------
A
----
G
--
N
G
S
W
T
E
P
T
Y
F
Y
V
T
D
26
HHSearch
63.04
13%
-11
- C2 -
3R8Q
-
A:
[14-261]
----------------------------------------------------------
T
P
T
S
L
S
A
Q
W
T
--
P
P
N
------
V
Q
L
T
G
Y
R
V
R
V
T
P
K
E
KT-------------
G
P
M
K
E
I
N
----------------------
L
A
P
D
S
S
S
V
V
V
S
-
G
L
M
V
A
T
K
Y
E
V
S
V
Y
A
L
K
-----
D
T
L
T
S
---
R
P
A
Q
G
V
V
T
T
L
---
E
N
V
S
-
P
P
R
R
A
R
V
T
----
D
A
--
T
E
T
T
I
T
I
S
W
R
--
T
K
T
---------
E
-----
T
I
--
T
G
F
Q
V
D
A
V
P
-
A
-
N
-
G
--
Q
-----
T
P
I
-
Q
R
T
I
---
K
--
P
D
V
R
S
Y
T
I
---
T
G
L
Q
P
G
T
D
Y
K
I
Y
L
Y
T
L
N
D
N
-----
A
-------
R
S
S
P
V
---
V
I
D
A
-----------------------------------------------------------------------------------
S
--
T
A
I
-
D
A
-
P
S
N
L
R
F
L
----
A
T
T
P
-
N
S
L
L
V
S
W
Q
P
P
R
-------
A
----
R
-----
I
T
G
Y
I
I
-
K
Y
----
E
----
K
P
G
S
P
--------
P
-----
R
-
E
-
V
-
V
PR-
P
----
R
----
P
--
G
V
T
E
A
T
I
T
--
G
L
E
P
G
T
E
Y
T
----
I
Y
V
I
A
L
K
N
N
-
Q
K
S
E
P
L
I
G
-
R
K
-
K
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
HHSearch
62.78
15%
-16
- C2 -
3R8Q
-
A:
[1-263]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
I
P
-
A
P
T
D
L
K
F
T
----
Q
V
--
T
P
T
S
L
S
A
Q
W
T
--
P
P
N
---------
V
-----
Q
L
--
T
G
Y
R
V
R
V
T
P
K
E
-
K
T
G
--
P
-----
M
K
E
-
I
-
N
L
---
A
--
P
D
S
S
S
V
V
V
---
S
G
L
M
V
A
T
K
Y
E
V
S
V
Y
A
L
K
D
T
-----
L
-------
T
S
R
P
A
Q
G
V
-
V
T
T
-----------------------------------------------------------------------------------
L
--
E
N
V
-
S
P
-
P
R
R
A
R
V
T
----
D
A
T
E
-
T
T
I
T
I
S
W
R
T
K
T
-------
E
----
T
-----
I
T
G
F
Q
V
-
D
A
----
V
----
P
A
N
G
Q
--------
T
P
----
I
-
Q
-
R
-
T
---
I
----
K
----
P
--
D
V
R
S
Y
T
I
T
--
G
L
Q
P
G
T
D
Y
K
----
I
Y
L
Y
T
L
N
D
N
-
A
R
S
S
P
V
-------
V
I
D
A
S
---
T
A
I
D
A
P
S
N
L
R
F
L
-
A
T
T
-----
P
N
S
L
L
V
S
W
Q
--
P
P
R
-----
A
--
R
I
T
G
----
Y
I
I
K
Y
E
----
K
P
G
S
-
P
-----
P
--
R
E
V
V
----
P
----
R
---
P
--------------
R
P
G
V
T
E
A
T
I
T
-
G
L
E
P
G
T
E
Y
T
I
Y
V
I
A
L
K
N
------
N
----
Q
--
K
S
E
P
L
I
G
R
K
K
T
---
30
HHSearch
61.75
14%
-9
- C2 -
1TDQ
-
A:
[16-278]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-
G
P
T
Q
I
L
V
R
----
D
V
--
S
D
T
V
A
F
V
E
W
T
--
P
P
R
----
A
----------
K
V
--
D
F
I
L
L
K
Y
G
L
V
G
G
E
-
G
--
G
-----
K
T
T
-
F
-
R
L
-----
Q
P
P
L
S
Q
Y
S
V
---
Q
A
L
R
P
G
S
R
Y
E
V
S
I
S
A
V
R
G
T
-----
N
-------
E
S
D
A
S
S
-
T
Q
F
T
---------------------------------------------------------------------------------------
T
E
I
-
D
A
-
P
K
N
L
R
V
G
----
S
R
T
A
-
T
S
L
D
L
E
W
D
N
S
E
-------
A
----
E
-----
A
Q
E
Y
K
V
-
V
Y
----
S
----
T
L
A
G
E
--------
Q
-----
Y
-
H
-
E
-
V
---
L
----
V
P
KGI
G
--
P
T
T
K
T
T
L
T
--
D
L
V
P
G
T
E
Y
G
----
V
G
I
S
A
V
M
N
S
-
K
Q
S
-
I
P
------
A
T
M
N
A
R
---
T
E
L
D
S
P
R
D
L
M
V
T
-
A
S
S
-----
E
T
S
I
S
L
I
W
T
--
K
A
S
-----
G
--
P
I
D
H
----
Y
R
I
T
F
T
----
P
S
S
G
-
I
-----
S
--
S
--
E
----
V
----
T
---
V
--------------
P
R
D
R
T
S
Y
T
L
T
-
D
L
E
P
G
A
E
Y
I
I
S
I
T
A
E
R
G
------
R
----
Q
--
Q
S
L
E
S
T
V
D
A
F
----
18
HHSearch
60.07
10%
-31
- C2 -
2GYS
2
IL3RB_HUMAN
A:
[15-418]
----------------------------------------------------------
Y
T
S
H
I
T
C
R
W
A
--
D
T
Q
--
D
--
A
Q
R
L
V
N
V
T
L
I
R
R
V
N
E
D
L
-------------
L
E
P
V
S
C
D
L
S
DDMPWSACPHP
R
--------
C
V
P
R
R
C
V
I
P
C
Q
-
S
F
V
V
T
D
V
D
Y
F
S
F
Q
P
D
R
-----
P
L
G
T
------
R
L
T
V
T
L
T
Q
H
--
V
Q
P
P
-
E
P
R
D
L
Q
I
S
-----
T
--
D
Q
D
H
F
L
L
T
W
S
--
V
A
L
----------HWLSP
G
D
--
L
E
F
E
V
V
Y
K
R
-
L
-
Q
-
D
--
S
-----
W
E
D
-
A
A
I
L
---
L
S
N
T
S
Q
A
T
L
G
P
---
E
H
L
M
P
S
S
T
Y
V
A
R
V
R
T
R
L
A
P
GSR
L
S
G
----
R
--
P
S
K
W
S
P
E
V
C
W
D
S
Q----------------------------------------------------------------------------------
P
--
G
D
E
-
A
Q
-
P
Q
N
L
E
C
F
----
F
D
G
A
-
A
V
L
S
C
S
W
E
V
R
K
----
E
V
-
A
----
S
-----
S
V
S
F
G
L
-
F
Y
----
K
----
P
----SA
V
L
L
R
E
E
E
-----
C
-
S
-
P
V
L
---
R
E
---
G
L
G
SL
H
--
T
R
H
H
C
Q
I
P
V
P
D
P
A
T
H
G
Q
Y
I
----
V
S
V
Q
P
R
R
A
E
-
K
H
I
K
-
S
-
S
----
V
N
-------
I
Q
M
A
P
P
-
S
L
Q
V
T
----------
D
S
Y
S
L
R
W
E
--
T
-----------
D
H
T
----
F
E
I
Q
Y
R
----
K
D
T
A
T
W
-----
K
--
D
--
S
----
K
T
---
E
---
T
--------------
L
Q
N
A
H
S
M
A
L
P
-
A
L
E
P
S
T
R
Y
W
A
R
V
R
V
R
T
S
------
R
TG
Y
N
G
-
I
W
S
E
W
S
E
A
R
S
W
D
T
--
28
HHSearch
59.99
13%
-4
* C2 *
3T1W
-
FINC_HUMAN
A:
[1173-1436]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
L
S
-
P
P
T
N
L
H
L
E
----
A
N
P-
D
T
G
V
L
T
V
S
W
E
--
R
S
T
----
T
----
P
-----
D
I
--
T
G
Y
R
I
T
T
T
P
T
N
-
G
-
Q
--
Q
-----
G
N
S
-
L
E
E
V
---
V
-
H
A
D
Q
S
S
C
T
F
---
D
N
L
S
P
G
L
E
Y
N
V
S
V
Y
T
V
K
D
D
-----
K
-------
E
S
V
P
I
---
S
D
T
I
-----------------------------------------------------------------------------------
I
--
P
E
V
-
P
Q
-
L
T
D
L
S
F
V
----
D
I
T
D
-
S
S
I
G
L
R
W
T
P
L
N
----
S
--
S
----
T
-----
I
I
G
Y
R
I
-
T
V
----
V
----
A
A
G
E
G
--------
I
PI---
F
-
E
-
D
-
F
---
V
----
D
----
S
--
S
V
G
Y
Y
T
V
T
--
G
L
E
P
G
I
D
Y
D
----
I
S
V
I
T
L
I
N
G
-
G
E
S
A
-
P
T
T
------
L
T
Q
Q
---
T
A
V
P
P
P
T
D
L
R
F
T
-
N
I
G
-----
P
D
T
M
R
V
T
W
A
--
P
P
P
S
----
I
--
D
L
T
N
----
F
L
V
R
Y
S
----
P
V
K
N
E
E
D
----
V
--
A
--
E
----
L
----
S
---
I
--------------
S
P
S
D
N
A
V
V
L
T
-
N
L
L
P
G
T
E
Y
V
V
S
V
S
S
V
Y
E
------
Q
----
H
----------------
34
Fugue
59.71
19%
-20
- C2 -
3MPC
1
?
A:
[3-98]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
A
P
-
A
F
-
P
T
G
L
S
A
V
----
L
D
S
S
G
N
T
A
N
L
T
W
N
A
A
P
------------
G
-----
A
N
S
Y
N
V
-
K
R
----
S
----
T
K
S
G
G
--------
P
-----
Y
-
T
-
T
-
I
---
A
----
T
N---
I
--
T
S
T
N
Y
T
D
T
--
G
V
A
T
G
T
K
Y
Y
----
Y
V
V
S
A
V
S
N
G
-
V
E
T
L
N
S
A
E
-
A
I
-
L
Q
Y
P
K
L
---
E
H
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
17
HHSearch
59.55
11%
-19
- C2 -
2Q7N
9
LIFR_MOUSE
A:
[16-486]
----------------------------------------------------------
N
M
R
V
W
D
C
T
W
P
--
A
P
L
--
G
--
V
S
P
G
T
V
K
D
I
C
I
K
D
R
------------------
F
H
S
C
H
P
------------
L
--------
E
---
T
T
N
V
K
I
P
-
A
L
S
P
G
---
D
H
E
V
T
I
N
Y
-----
L
N
G
F
Q
---
S
K
F
T
L
-
N
E
K
D
V
S
-
L
I
P
E
-
T
P
E
I
L
D
L
S
A
---
D
F
--
F
T
S
S
L
L
L
K
W
N
--
D
R
G
----
S
ALP
H
P
-----
S
N
--
A
T
W
E
I
K
V
L
Q
N
P
-
R
-
T
EP
V
-----
A
L
V
-
L
L
N
T
M
L
S
G
-
K
D
T
V
Q
H
W
N
W
T
S
D
L
P
L
-
Q
C
A
T
H
S
V
S
I
R
W
H
I
D
S
-----
P
HFSG
Y
K
E
W
S
D
W
S
P
L
K
N
I
S
W
IRNTETNVFPQD
K
V
V
L
AGSN
M
T
I
C
C
M
S
PTKVL
S
G
Q
I
GNTLRPLIHLYGQT
V
A
I
H
ILNIPVSENS
G
T
N
I
I
F
I
T
D
D
D
V
Y
G
T
V
V
F
A
G
--
Y
P
P
-
D
V
-
P
Q
K
L
S
C
E
----
T
H
D
L
-
K
E
I
I
C
S
W
N
P
G
R
----
I
--
T
----
G
LVGPR
N
T
E
Y
T
L
-
F
E
----
S
----
I
S
G
K
S
--------
A
-----
V
-
F
-
H
-
R
---
I
EGL-
T
----
N
--
E
T
Y
R
L
G
V
Q
--
M
H
P
G
Q
E
I
H
N
----
F
T
L
T
G
R
N
P
L
-
G
Q
A
Q
S
A
-
V
--
V
-
I
N
V
T
E
R
---
V
A
P
H
D
P
T
S
L
K
V
K
-
D
I
N
-----
S
T
V
V
T
F
S
W
Y
--
L
P
G
N
FT--
K
--
I
N
L
L
----
C
Q
I
E
I
C
----
K
A
N
S
-
K
K
----
E
--
V
--
R
----
N
A
T
I
R
G
---
A
--------------
E
D
S
T
Y
H
V
A
V
D
-
K
L
N
P
Y
T
A
Y
T
F
R
V
R
C
S
S
K
------
T
----
F
W
K
W
S
R
W
S
D
E
K
R
H
L
T
T
E
5
PsiBlast_PDB
59.54
22%
-13
- C2 -
4PBX
-
PTPRS_HUMAN
A:
[419-568]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
G
Y
R
V
Y
Y
T
--
M
E
P
----
E
----
H
-----
P
V
--
G
N
W
--
Q
K
H
N
-
V
-
D
-
D
--
S
-----
L
L
T
T
V
G
S
L
-------------------
L
E
D
-
E
T
Y
T
V
R
V
L
A
F
T
S
V
-----
G
----
D
--
G
P
L
S
D
P
I
Q
V
K
T
Q
-----------------------------------------------------------------------------------
Q
--
G
V
P
-
G
Q
-
P
M
N
L
R
A
E
----
A
R
S
E
-
T
S
I
T
L
S
W
S
P
P
R
----
Q
--
E
----
S
-----
I
I
K
Y
E
L
-
L
F
----------
R
E
G
D
--------
H
-----
G
-
R
-
E
-
V
---
G
----
R
----
T
F
D
P
T
T
S
Y
V
V
E
--
D
L
K
P
N
T
E
Y
A
----
F
R
L
A
A
R
S
P
Q
-
G
L
G
A
F
T
P
V
-
V
R
-
Q
R
T
L
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
HHSearch
58.58
13%
-20
- C2 -
3S98
1
INAR1_HUMAN
A:
[8-300]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
V
E
V
D
----
I
I
---
D
D
N
F
I
L
R
W
N
------------------------
V
T
F
S
F
D
Y
Q
K
T
G
-
M
-
D
--
N
-----
W
I
K
-
L
S
G
C
---
Q
-
N
I
T
S
T
K
C
N
F
---
S
S
-
N
V
Y
E
E
I
K
L
R
I
R
A
E
K
E
------
N
-------
T
S
S
W
Y
E
V
D
S
F
T
P
-----------------------------------------------------------------------------------
F
RK
A
Q
I
-
G
P
-
P
-
E
V
H
L
E
----
A
E
-
D
-
K
A
I
V
I
H
I
S
P
G
---------SVMW------
S
F
T
Y
S
L
-
V
I
----
W
----
K
N
S
S
G
--------
V
-----
E
-
E
-
R
-
I
---
E
---------
N
--
I
Y
S
R
H
K
I
Y
--
K
L
S
P
E
T
T
Y
C
----
L
K
V
K
A
A
L
L
T
S
W
K
I
G
V
Y
S
P
-
V
H
C
I
K
T
T
V
E
---
N
E
L
P
P
P
E
N
I
E
V
S
-
V
-
Q
-----
N
Q
N
Y
V
L
K
W
D
--
Y
T
Y
A
--------
N
M
T
F
Q
V
Q
W
L
H
A
F
L
KRNP-----
Y
-----
K
--
W
--
K
----
Q
----
I
PDC
E
--------------
N
V
K
T
T
Q
C
V
F
P
Q
N
V
F
Q
K
G
I
Y
L
L
R
V
Q
A
S
D
G
------
N
----
N
--
T
S
F
W
S
E
E
I
K
F
D
T
--
25
HHSearch
57.86
11%
-19
- C2 -
3L5I
20
A:
[21-290]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Y
R
T
V
Q
L
V
W
K
TL
P
P
F
----
E
AN--
G
-----
K
I
--
L
D
Y
E
V
T
L
T
R
-
W
-
K
-
S
--
H
-----
L
Q
N
-
Y
T
--------
V
N
A
T
K
L
T
V
---
N
-
L
-
T
N
D
R
Y
L
A
T
L
T
V
R
N
L
V
-----
G
-------
K
S
D
A
A
V
L
T
I
P
A
C
D----------------------------------------------------------------------------------
F
--
Q
A
T
-
H
P
-
V
M
D
L
K
A
F
----
P
K
D
--
N
M
L
W
V
E
W
T
T
P
R
-------
E
----
S
-----
V
K
K
Y
I
L
-
E
W
----
C
----
V
L
S
D
K
APC
I
T
---
D
-----
W
-
Q
-
Q
-
E
---
D
----
G
----
T
--
V
H
R
T
Y
L
R
G
--
N
L
A
E
S
K
C
Y
L
----
I
T
V
T
P
V
Y
A
D
-
G
P
G
S
P
E
-
S
-
I
--
K
A
Y
L
K
Q
---
A
P
P
S
K
G
P
T
V
R
T
K
-
K
V
G
-----
K
N
E
A
V
L
E
W
D
--
Q
L
P
V
DVQN
G
--
F
I
R
N
----
Y
T
I
F
Y
R
----
T
I
I
G
-
N
-----
E
--
T
--
A
----
V
----
N
---
V
--------------
D
S
S
H
T
E
Y
T
L
S
-
S
L
T
S
D
T
L
Y
M
V
R
M
A
A
Y
T
D
------
E
----
G
--
G
K
-
D
G
P
E
F
T
F
T
T
P
K
1
PsiBlast_PDB
57.28
27%
-1
- C2 -
4YH7
-
PTPRD_MOUSE
A:
[276-434]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
S
A
N
Y
T
C
V
A
M
S
T
L
-----
G
----
V
--
I
E
---
A
I
A
Q
I
T
V
-----------------------------------------------------------------------------------
K
--
A
L
P
-
K
P
-
P
G
T
P
V
V
T
----
E
S
T
A
-
T
S
I
T
L
T
W
D
S
G
N
----
P
--
E
----
P
-----
V
S
Y
Y
I
I
Q
H
K
----
P
----
K
N
S
E
E
--------
P
-----
Y
-
K
-
E
-
I
---
D
----
G
----
I
--
A
T
T
R
Y
------
S
V
A
G
L
S
P
Y
S
D
Y
E
F
R
V
V
A
V
N
N
I
-
G
R
G
P
A
--
S
-
E
P
-
V
L
T
Q
T
S
---
E
--
Q
A
P
S
S
A
P
R
D
-
V
-
Q
A
R
M
L
S
S
T
T
I
L
V
Q
W
K
E
P
E
E
P
N
----
G
--
Q
I
Q
G
----
Y
R
V
Y
Y
T
----
M
D
P
T
-
Q
-----
H
--
V
--
N
----
N
----
W
---
M
--------------
K
H
N
V
A
D
S
Q
I
T
-
T
I
G
N
L
V
P
Q
K
T
Y
S
V
K
V
L
A
------
F
----
T
-
S
I
G
D
G
P
L
S
S
D
I
Q
V
I
T
16
HHSearch
56.00
11%
-16
- C2 -
2V5Y
4
PTPRM_HUMAN
A:
[275-568]
-----------------------------------------------------------
A
T
Y
L
W
I
Q
L
N
--
A
N
S
--
I
NG
D
G
P
I
V
A
R
E
V
E
Y
C
T
A
S
---------------
G
S
W
N
D
R
Q
P
------------
V
-----------
D
S
T
S
Y
K
I
G
-
H
L
D
P
D
T
E
Y
E
I
S
V
L
L
T
R
P
G---
E
G
G
T
G
---
S
P
G
P
A
L
R
T
R
T
K
C
A
D
P
M
R
-
G
P
R
K
L
E
V
V
----
E
V
--
K
S
R
Q
I
T
I
R
W
E
--
P
F
G
----
Y
----
N
VT---
R
C
H
S
Y
N
L
T
V
H
Y
C
Y
Q
V
-
G
-
G
Q
E
Q
-----
V
R
E
E
V
S
W
D
---
T
-
E
N
S
H
P
Q
H
T
I
---
T
N
L
S
P
Y
T
N
V
S
V
K
L
I
L
M
N
P
E
-----
G
----
R
---
K
E
-
S
Q
E
L
I
V
Q
T
-----------------------------------------------------------------------------------
D
E-
D
L
P
G
A
V
-
P
T
E
S
I
Q
G
----
S
T
F
E
-
E
K
I
F
L
Q
W
R
E
P
T
----
Q
TY
G
----
V
-----
I
T
L
Y
E
I
-
T
Y
----
K
----
A
V
S
S
F
--------
D
DLSN
Q
S
-
G
-
R
V
S
---
K
----
L
----
G
--
N
E
T
H
F
L
F
F
--
G
L
Y
P
G
T
T
Y
S
----
F
T
I
R
A
S
T
A
K
-
G
F
-
G
P
P
A
T
--
N
-
Q
F
T
T
K
I
---
S
A
P
S
M
--------------------------------------------------------------------------------------------------------------------------------------------------------------