@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_0685: (2015-12-17 )
MSVIIAANNLCLQYQQNEPVIKHANLRIKRKDFVFISGPSGSGKSTLLRSFYGDLKVFSGKLEVCNINMNNASKSTILDLRKNIGVVFQDYKLIQDYTIEQNIKLPMVICGIKKEECHLQLEKLLGHIDLRHKANRYPKELSGGEQQRVAMARAMANCPELILADEPTGNLDDYSSDKIWSLLRGMNTQLNATIVVVTHKFPKNFSAYHRKFYIEEGEVYEYS
Atome Classification :
(45 SA)
.........10......---..20---....---....30........40......---..50.----...------....60........70---------....----------...-..80..-......90.-.......100.-..-....---110........120.......----130.-.-.-....140--.........150.......160.......170.......180.......190-.......200........-.210.......220.-------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
S
V
I
I
A
AN
N
L
C
L
Q
YQQN---EP
V
I
---KHA
N
---
L
R
I
K
RK
D
F
V
F
I
SGPSGS
G
K
S
T
L
---
L
R
S
F
Y----GD
L
------
K
V
FS
G
K
L
E
V
C
N
I
NMN----------NAS
K
----------
S
T
I
-
L
D
L
R
K
N-I
G
V
V
F
Q
D
Y
K
-
L
I
Q
D
Y
TIEQNI-KL-
P
M
V
I
---C-GI
K
K
E
E
C
H
L
Q
L
E
K
L
L
G
H
I
D
----
L
R
H
K
-A-N-RY
P
K
E----LSG
G
E
Q
Q
R
V
A
M
A
R
A
M
ANCP
E
L
I
LADEPTGNLDDYS
S
D
K
I
W
S
L
L
R
GMNTQL
N
A
-
T
I
V
V
V
THK--FPKN
F
S
A
Y
-
H
R
K
F
Y
IEEG
E
V
YEYS-------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
95.01
39%
-112
- C1 -
1L2T
4
Y796_METJA
A:
[1-223]
---
M
I
K
L
K
N
V
T
K
T
Y
K
M
G
---
E
E
I
I
Y
AL
K
N
V
N
---
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
---
L
N
I
I
G
----
C
L
D
------
K
P
T
E
G
E
V
Y
I
D
N
I
K
T
N
----------
D
L
D
D
----------
D
E
L
-
T
K
I
R
R
D
K
I
G
F
V
F
Q
Q
F
N
-
L
I
P
L
L
T
A
L
E
N
V
-
E
L
-
P
L
I
F
KYR
G
-
A
M
S
G
E
E
R
R
K
R
A
L
E
C
L
K
M
A
E
----
L
E
E
R
F
A
-
N
-
H
K
P
N
Q
----
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
G
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
D
G
K
-
T
V
V
V
V
T
H
D
--
I
--
N
V
A
R
F
G
E
R
I
I
Y
L
K
D
G
E
V
E
R
E
E
-------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
93.67
38%
-115
- C1 -
3TIF
7
Y796_METJA
A:
[1-223]
---
M
V
K
L
K
N
V
T
K
T
Y
K
M
G
---
E
E
I
I
Y
AL
K
N
V
N
---
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
---
L
N
I
I
G
----
C
L
D
------
K
P
T
E
G
E
V
Y
I
D
N
I
K
T
N
----------
D
L
D
D
----------
D
E
L
-
T
K
I
R
R
D
K
I
G
F
V
F
Q
Q
F
N
-
L
I
P
L
L
T
A
L
E
N
V
-
E
L
-
P
L
I
F
KYR
G
-
A
M
S
G
E
E
R
R
K
R
A
L
E
C
L
K
M
A
E
----
L
E
E
R
F
A
-
N
-
H
K
P
N
Q
----
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
W
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
D
G
K
-
T
V
V
V
V
T
H
D
--
I
--
N
V
A
R
F
G
E
R
I
I
Y
L
K
D
G
E
V
E
R
E
E
-------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
93.41
39%
-109
- C1 -
1L2T
4
Y796_METJA
B:
[1-223]
---
M
I
K
L
K
N
V
T
K
T
Y
K
M
G
---
E
E
I
I
YAL
K
N
V
N
---
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
---
L
N
I
I
G
----
C
L
D
------
K
P
T
E
G
E
V
Y
I
D
N
I
K
T
N
----------
D
L
D
D
----------
D
E
L
-
T
K
I
R
R
D
K
I
G
F
V
F
Q
Q
F
N
-
L
I
P
L
L
T
A
L
E
N
V
-
E
L
-
P
L
I
F
KYR
G
-
A
M
S
G
E
E
R
R
K
R
A
L
E
C
L
K
M
A
E
----
L
E
E
R
F
A
-
N
-
H
K
P
N
Q
----
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
G
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
D
G
K
-
T
V
V
V
V
T
H
D
--
I
--
N
V
A
R
F
G
E
R
I
I
Y
L
K
D
G
E
V
E
R
E
E
-------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
93.32
39%
-110
- C1 -
1F3O
2
Y796_METJA
A:
[2-223]
----
I
K
L
K
N
V
T
K
T
Y
K
M
G
---
E
E
I
I
YAL
K
N
V
N
---
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
---
L
N
I
I
G
----
C
L
D
------
K
P
T
E
G
E
V
Y
I
D
N
I
K
T
N
----------
D
L
D
D
----------
D
E
L
-
T
K
I
R
R
D
K
I
G
F
V
F
Q
Q
F
N
-
L
I
P
L
L
T
A
L
E
N
V
-
E
L
-
P
L
I
F
K
YR
G
-
A
M
S
G
E
E
R
R
K
R
A
L
E
C
L
K
M
A
E
----
L
E
E
R
F
A
-
N
-
H
K
P
N
Q
----
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
E
P
T
G
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
D
G
K
-
T
V
V
V
V
T
H
D
--
I
--
N
V
A
R
F
G
E
R
I
I
Y
L
K
D
G
E
V
E
R
E
E
-------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
91.74
38%
-113
- C1 -
3TIF
7
Y796_METJA
B:
[1-223]
---
M
V
K
L
K
N
V
T
K
T
Y
K
M
G
---
E
E
I
I
YAL
K
N
V
N
---
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
---
L
N
I
I
G
----
C
L
D
------
K
P
T
E
G
E
V
Y
I
D
N
I
K
T
N
----------
D
L
D
D
----------
D
E
L
-
T
K
I
R
R
D
K
I
G
F
V
F
Q
Q
F
N
-
L
I
P
L
L
T
A
L
E
N
V
-
E
L
-
P
L
I
F
KYR
G
-
A
M
S
G
E
E
R
R
K
R
A
L
E
C
L
K
M
A
E
----
L
E
E
R
F
A
-
N
-
H
K
P
N
Q
----
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
W
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
D
G
K
-
T
V
V
V
V
T
H
D
--
I
--
N
V
A
R
F
G
E
R
I
I
Y
L
K
D
G
E
V
E
R
E
E
-------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
78.81
39%
-103
- C1 -
2PCL
12
LOLD_AQUAE
A:
[2-217]
-
A
E
I
L
R
A
E
N
I
K
K
V
I
R
G
Y
---
E
-
I
L
---
K
G
I
S
---
L
S
V
K
K
G
E
F
V
S
I
I
G
A
S
G
S
G
K
S
T
L
---
L
-
Y
I
L
----
G
L
L
DAPT
E
G
K
V
F
---
L
E
G
K
E
V
D
Y
T
----------
N
E
K
E
----------
L
S
L
-
L
R
N
R
K
--
L
G
F
V
F
Q
F
H
Y
-
L
I
P
E
L
T
A
L
E
N
V
-
I
V
-
P
M
L
K
---
M
-
G
K
P
K
K
E
A
K
E
R
G
E
Y
L
L
S
E
L
G
----
L
G
D
K
-
L
-
S
-
R
K
P
Y
E
----
L
S
G
G
E
Q
Q
R
V
A
I
A
R
A
L
A
N
E
P
I
L
L
F
A
D
E
P
T
G
N
L
D
S
A
N
T
K
R
V
M
D
I
F
L
K
I
N
-
E
G
G
T
-
S
I
V
M
V
T
H
E
---
R
E
L
A
E
L
T
-
H
R
T
L
E
M
K
D
G
K
V
V
G
E
I
-------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
78.78
39%
-106
- C1 -
2PCJ
1
LOLD_AQUAE
B:
[2-217]
-
A
E
I
L
R
A
E
N
I
K
K
V
I
R
G
Y
---
E
-
I
L
---
K
G
I
S
---
L
S
V
K
K
G
E
F
V
S
I
I
G
A
S
G
S
G
K
S
T
L
---
L
-
Y
I
L
----
G
L
L
DAPTEG
K
V
F
---
L
E
G
K
E
V
D
Y
T
----------
N
E
K
E
----------
L
S
L
-
L
R
N
R
K
--
L
G
F
V
F
Q
F
H
Y
-
L
I
P
E
L
T
A
L
E
N
V
-
I
V
-
P
M
L
K
---
M
-
G
K
P
K
K
E
A
K
E
R
G
E
Y
L
L
S
E
L
G
----
L
G
D
K
-
L
-
S
-
R
K
P
Y
E
----
L
S
G
G
E
Q
Q
R
V
A
I
A
R
A
L
A
N
E
P
I
L
L
F
A
D
E
P
T
G
N
L
D
S
A
N
T
K
R
V
M
D
I
F
L
K
I
N
-
E
G
G
T
-
S
I
V
M
V
T
H
E
---
R
E
L
A
E
L
T
-
H
R
T
L
E
M
K
D
G
K
V
V
G
E
I
-------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
75.34
39%
-99
- C1 -
2PCJ
-
LOLD_AQUAE
A:
[2-217]
-
A
E
I
L
R
A
E
N
I
K
K
V
I
R
G
Y
---
E
-
I
L
---
K
G
I
S
---
L
S
V
K
K
G
E
F
V
S
I
I
G
A
S
G
S
G
K
S
T
L
---
L
-
Y
I
L
----
G
L
L
DAPT
E
G
K
V
F
---
L
E
G
K
E
V
D
Y
T
----------
N
E
K
E
----------
L
S
L
-
L
R
N
R
K
--
L
G
F
V
F
Q
F
H
Y
-
L
I
P
E
L
T
A
L
E
N
V
-
I
V
-
P
M
L
K
---
M
-
G
K
P
K
K
E
A
K
E
R
G
E
Y
L
L
S
E
L
G
----
L
G
D
K
-
L
-
S
-
R
K
P
Y
E
----
L
S
G
G
E
Q
Q
R
V
A
I
A
R
A
L
A
N
E
P
I
L
L
F
A
D
E
P
T
G
N
L
D
S
A
N
T
K
R
V
M
D
I
F
L
K
I
N
-
E
G
G
T
-
S
I
V
M
V
T
H
E
---
R
E
L
A
E
L
T
-
H
R
T
L
E
M
K
D
G
K
V
V
G
E
I
-------------------------------------------------------------------------------------------------------------------------------
120
HHSearch
75.28
29%
-100
- C1 -
3GFO
1
ECFA3_CLOP1
A:
[5-226]
-
D
Y
I
L
K
V
E
E
L
N
Y
N
Y
S
D
G
---
T
H
A
L
---
K
G
I
N
---
M
N
I
K
R
G
E
V
T
A
I
L
G
G
N
G
V
G
K
S
T
L
---
F
Q
N
F
N
----
G
I
L
------
K
P
S
S
G
R
I
L
F
D
N
K
P
I
D
----------
Y
S
R
K
-----------
G
I
-
M
K
L
R
E
S
-
I
G
I
V
F
Q
D
P
D
N
Q
L
F
S
A
S
V
Y
Q
D
V
-
S
F
-
G
A
V
N
---
M
-
K
L
P
E
D
E
I
R
K
R
V
D
N
A
L
K
R
T
G
----
I
E
H
L
-
K
-
D
-
K
P
T
H
C
----
L
S
F
G
Q
K
K
R
V
A
I
A
G
V
L
V
M
E
P
K
V
L
I
L
D
E
P
T
A
G
L
D
P
M
G
V
S
E
I
M
K
L
L
V
E
M
Q
K
E
L
G
I
-
T
I
I
I
A
T
H
D
--
I
D
I
V
P
L
Y
C
-
D
N
V
F
V
M
K
E
G
R
V
I
L
Q
G
-------------------------------------------------------------------------------------------------------------------------------
129
HHSearch
74.38
30%
-102
- C1 -
1B0U
4
HISP_SALTY
A:
[5-235]
--
N
K
L
H
V
I
D
L
H
K
R
Y
G
-
G
---
H
E
V
L
---
K
G
V
S
---
L
Q
A
R
A
G
D
V
I
S
I
I
G
S
S
G
S
G
K
S
T
F
---
L
R
C
I
N
----
F
L
E
------
K
P
S
E
G
A
I
I
V
N
G
Q
N
I
N
----------
L
V
R
D
KDGQLKVAD
K
N
Q
L
-
R
L
L
R
T
R
-
L
T
M
V
F
Q
H
F
N
-
L
W
S
H
M
T
V
L
E
N
V
-
M
E
-
A
P
I
Q
---
V
L
G
L
S
K
H
D
A
R
E
R
A
L
K
Y
L
A
K
V
G
----
I
D
E
R
-
A
Q
G
-
K
Y
P
V
H
----
L
S
G
G
Q
Q
Q
R
V
S
I
A
R
A
L
A
M
E
P
D
V
L
L
F
D
E
P
T
S
A
L
D
P
E
L
V
G
E
V
L
R
I
M
Q
Q
L
A
E
-
E
G
K
-
T
M
V
V
V
T
H
E
--
M
G
F
A
R
H
V
S
-
S
H
V
I
F
L
H
Q
G
K
I
E
E
E
G
-------------------------------------------------------------------------------------------------------------------------------
86
PsiBlast_CBE
72.52
31%
-102
- C1 -
1B0U
4
HISP_SALTY
A:
[21-233]
----------------------
V
L
---
K
G
V
S
---
L
Q
A
R
A
G
D
V
I
S
I
I
G
S
S
G
S
G
K
S
T
F
---
L
R
C
I
N
----
F
L
E
------
K
P
S
E
G
A
I
I
V
N
G
Q
N
I
N
L
V
R
D
KDGQLK
V
A
D
K
----------
N
Q
L
-
R
L
L
R
T
R
-
L
T
M
V
F
Q
H
F
N
-
L
W
S
H
M
T
V
L
E
N
V
M
E
A
-
P
I
Q
V
---
L
-
G
L
S
K
H
D
A
R
E
R
A
L
K
Y
L
A
K
V
G
----
I
D
E
R
-
A
-
Q
G
K
Y
P
V
H
----
L
S
G
G
Q
Q
Q
R
V
S
I
A
R
A
L
A
M
E
P
D
V
L
L
F
D
E
P
T
S
A
L
D
P
E
L
V
G
E
V
L
R
I
M
Q
Q
L
A
E
E
-
G
K
-
T
M
V
V
V
T
H
E
M
G
F
A
R
H
V
S
S
H
---
V
I
F
L
H
Q
G
K
I
E
E
E
G
-------------------------------------------------------------------------------------------------------------------------------
126
HHSearch
72.45
32%
-101
- C1 -
2OLJ
4
?
A:
[22-241]
-
L
Q
M
I
D
V
H
Q
L
K
K
S
F
G
-
S
---
L
E
V
L
---
K
G
I
N
---
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
---
L
R
C
L
N
----
L
L
E
------
D
F
D
E
G
E
I
I
I
D
G
I
N
L
K
----------
A
K
D
T
-----------
N
L
-
N
K
V
R
E
E
-
V
G
M
V
F
Q
R
F
N
-
L
F
P
H
M
T
V
L
N
N
I
-
T
L
-
A
P
M
K
---
V
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
----
L
K
D
K
-
A
-
H
-
A
Y
P
D
S
----
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
-
E
G
M
-
T
M
V
V
V
T
H
E
--
M
G
F
A
R
E
V
G
-
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
-------------------------------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
71.33
31%
-112
- C1 -
3TUZ
1
METN_ECOLI
C:
[24-224]
---
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
---
T
R
T
I
---
Q
A
L
N
NVS
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
---
I
R
C
V
N
----
L
L
E
------
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
----------
T
L
S
E
----------
S
E
L
-
T
K
A
R
R
Q
-
I
G
M
I
F
Q
H
F
N
-
L
L
S
S
R
T
V
F
G
N
V
-
A
L
-
P
L
E
L
---
D
-
N
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
----
L
G
D
K
-
H
-
D
-
S
Y
P
S
N
----
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
-
T
I
L
L
I
T
H
E
--
M
D
V
V
K
R
I
C
-
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
-------------------------------------------------------------------------------------------------------------------------------
127
HHSearch
71.28
36%
-94
- C1 -
2PCJ
-
LOLD_AQUAE
A:
[2-220]
-
A
E
I
L
R
A
E
N
I
K
K
V
I
R
-
G
---
Y
E
I
L
---
K
G
I
S
---
L
S
V
K
K
G
E
F
V
S
I
I
G
A
S
G
S
G
K
S
T
L
---
L
Y
I
L
G
----
L
L
D
------
A
P
T
E
G
K
V
F
L
E
G
K
E
V
D
----------
Y
T
N
E
----------
K
E
L
S
L
L
R
N
R
K
-
L
G
F
V
F
Q
F
H
Y
-
L
I
P
E
L
T
A
L
E
N
V
-
I
V
-
P
M
L
K
---
M
-
G
K
P
K
K
E
A
K
E
R
G
E
Y
L
L
S
E
L
G
----
L
G
D
K
-
L
-
S
-
R
K
P
Y
E
----
L
S
G
G
E
Q
Q
R
V
A
I
A
R
A
L
A
N
E
P
I
L
L
F
A
D
E
P
T
G
N
L
D
S
A
N
T
K
R
V
M
D
I
F
L
K
I
N
E
-
G
G
T
-
S
I
V
M
V
T
H
E
--
R
E
L
A
E
L
T
H
-
R
-
T
L
E
M
K
D
G
K
V
V
G
E
I
-------------------------------------------------------------------------------------------------------------------------------
118
HHSearch
71.15
30%
-98
- C1 -
3RLF
3
MALK_ECOLI
A:
[2-216]
--
A
S
V
Q
L
Q
N
V
T
K
A
W
G
-
E
---
V
V
V
S
---
K
D
I
N
---
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
---
L
R
M
I
A
----
G
L
E
------
T
I
T
S
G
D
L
F
I
G
E
K
R
M
N
----------
D
T
P
----------------
P
A
E
R
G
-
V
G
M
V
F
Q
S
Y
A
-
L
Y
P
H
L
S
V
A
E
N
M
-
S
F
-
G
L
K
L
---
A
-
G
A
K
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
----
L
A
H
L
-
L
-
D
-
R
K
P
K
A
----
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
-
T
M
I
Y
V
T
H
D
--
Q
V
E
A
M
T
L
A
-
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
-------------------------------------------------------------------------------------------------------------------------------
111
HHSearch
70.44
30%
-96
- C1 -
3TUI
1
METN_ECOLI
C:
[23-246]
--
H
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
TRT
I
Q
A
L
---
N
N
V
S
---
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
---
I
R
C
V
N
----
L
L
E
------
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
----------
T
L
S
E
----------
S
E
L
-
T
K
A
R
R
Q
-
I
G
M
I
F
Q
H
F
N
-
L
L
S
S
R
T
V
F
G
N
V
-
A
L
-
P
L
E
L
---
D
-
N
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
----
L
G
D
K
-
H
-
D
-
S
Y
P
S
N
----
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
-
T
I
L
L
I
T
H
E
--
M
D
V
V
K
R
I
C
-
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
-------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
67.89
34%
-100
- C1 -
2OUK
1
?
A:
[39-239]
----------------------
V
L
---
K
G
I
N
---
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
---
L
R
C
L
N
----
L
L
E
------
D
F
D
E
G
E
I
I
I
D
G
I
N
L
K
-----------
A
K
D
----------
T
N
L
-
N
K
V
R
E
E
-
V
G
M
V
F
Q
R
F
N
-
L
F
P
H
M
T
V
L
N
N
I
-
T
L
A
P
M
K
V
---
R
-
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
----
L
K
D
K
-
A
-
H
-
A
Y
P
D
S
----
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
-
T
M
V
V
V
T
H
E
--
M
G
F
A
R
E
V
G
-
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
-------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
67.63
34%
-95
- C1 -
2OLK
1
?
A:
[39-239]
----------------------
V
L
---
K
G
I
N
---
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
---
L
R
C
L
N
----
L
L
E
------
D
F
D
E
G
E
I
I
I
D
G
I
N
L
K
-----------
A
K
D
----------
T
N
L
-
N
K
V
R
E
E
-
V
G
M
V
F
Q
R
F
N
-
L
F
P
H
M
T
V
L
N
N
I
-
T
L
A
P
M
K
V
---
R
-
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
----
L
K
D
K
-
A
-
H
-
A
Y
P
D
S
----
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
-
T
M
V
V
V
T
H
E
--
M
G
F
A
R
E
V
G
-
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
-------------------------------------------------------------------------------------------------------------------------------
48
PsiBlast_CBE
67.59
31%
-110
- C1 -
3TUZ
1
METN_ECOLI
H:
[24-224]
---
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
---
T
R
T
I
---
Q
A
L
N
NVS
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
---
I
R
C
V
N
----
L
L
E
------
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
----------
T
L
S
E
----------
S
E
L
-
T
K
A
R
R
Q
-
I
G
M
I
F
Q
H
F
N
-
L
L
S
S
R
T
V
F
G
N
V
-
A
L
-
P
L
E
L
---
D
-
N
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
----
L
G
D
K
-
H
-
D
-
S
Y
P
S
N
----
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
-
T
I
L
L
I
T
H
E
--
M
D
V
V
K
R
I
C
-
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
-------------------------------------------------------------------------------------------------------------------------------
105
Fugue
67.42
30%
-92
- C1 -
1Z47
1
?
A:
[11-355]
G
S
M
T
I
E
F
V
G
V
E
K
I
Y
P
G
G
---
A
R
S
V
---
R
G
V
S
---
F
Q
I
R
E
G
E
M
V
G
L
L
G
P
S
G
S
G
K
T
T
I
---
L
R
L
I
A
----
G
L
E
------
R
P
T
K
G
D
V
W
I
G
G
K
R
V
T
----------
D
L
P
----------------
P
Q
K
R
N
-
V
G
L
V
F
Q
N
Y
A
-
L
F
Q
H
M
T
V
Y
D
N
V
-
S
F
-
G
L
R
E
---
K
-
R
V
P
K
D
E
M
D
A
R
V
R
E
L
L
R
F
M
R
----
L
E
S
Y
-
A
-
N
-
R
F
P
H
E
----
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
A
P
R
P
Q
V
L
L
F
D
E
P
F
A
A
I
D
T
Q
I
R
R
E
L
R
T
F
V
R
Q
V
H
D
E
M
G
V
-
T
S
V
F
V
T
H
D
--
Q
E
E
A
L
E
V
A
-
D
R
V
L
V
L
H
E
G
N
V
E
Q
F
G
T
P
E
E
V
Y
EKPGT
L
F
V
A
S
F
IGE
S
N
V
W
T
R
A
V
Q
NG
R
I
E
V
AG
A
A
L
P
V
DPAVSEG
S
E
V
A
V
V
V
R
PKD
V
E
L
Q
P
A
S
EREAHAQVV
R
S
A
F
KGS
Y
S
A
C
W
I
R
T
KD
G
E
V
W
E
V
H
V
P
SADRHRWSPG
A
W
V
H
M
N
V
T
R
W
F
I
F
P
R
36
PsiBlast_CBE
65.67
34%
-95
- C1 -
2OLK
1
?
C:
[39-239]
----------------------
V
L
---
K
G
I
N
---
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
---
L
R
C
L
N
----
L
L
E
------
D
F
D
E
G
E
I
I
I
D
G
I
N
L
K
-----------
A
K
D
----------
T
N
L
-
N
K
V
R
E
E
-
V
G
M
V
F
Q
R
F
N
-
L
F
P
H
M
T
V
L
N
N
I
-
T
L
A
P
M
K
V
---
R
-
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
----
L
K
D
K
-
A
-
H
-
A
Y
P
D
S
----
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
-
T
M
V
V
V
T
H
E
--
M
G
F
A
R
E
V
G
-
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
-------------------------------------------------------------------------------------------------------------------------------
40
PsiBlast_CBE
64.57
34%
-93
- C1 -
4YMU
2
?
A:
[16-216]
----------------------
V
L
---
K
G
V
T
---
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
---
L
R
C
I
N
----
L
L
E
------
E
P
T
K
G
E
V
F
I
D
G
V
K
I
N
----------
N
G
-
K
----------
V
N
I
-
N
K
V
R
Q
K
-
V
G
M
V
F
Q
H
F
N
-
L
F
P
H
L
T
A
I
E
N
I
-
T
L
A
P
V
K
V
---
K
-
K
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
----
L
L
D
K
-
K
-
D
-
Q
Y
P
I
K
----
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
E
-
G
M
-
T
M
V
V
V
T
H
E
--
M
G
F
A
R
E
V
G
-
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
-------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
64.03
34%
-91
- C1 -
4YMV
1
?
J:
[16-216]
----------------------
V
L
---
K
G
V
T
---
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
---
L
R
C
I
N
----
L
L
E
------
E
P
T
K
G
E
V
F
I
D
G
V
K
I
N
----------
N
G
-
K
----------
V
N
I
-
N
K
V
R
Q
K
-
V
G
M
V
F
Q
H
F
N
-
L
F
P
H
L
T
A
I
E
N
I
-
T
L
A
P
V
K
V
---
K
-
K
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
----
L
L
D
K
-
K
-
D
-
Q
Y
P
I
K
----
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
E
-
G
M
-
T
M
V
V
V
T
H
E
--
M
G
F
A
R
E
V
G
-
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
-------------------------------------------------------------------------------------------------------------------------------
47
PsiBlast_CBE
63.67
32%
-94
- C1 -
4U00
3
?
A:
[19-218]
----------------------
V
L
---
K
G
I
H
---
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
---
I
R
T
I
N
----
R
L
E
------
D
F
Q
E
G
E
V
V
V
D
G
L
S
V
K
----------
D
--
D
----------
R
A
L
-
R
E
I
R
R
E
-
V
G
M
V
F
Q
Q
F
N
-
L
F
P
H
M
T
V
L
E
N
V
-
T
L
A
P
M
R
V
---
R
-
R
W
P
R
E
K
A
E
K
K
A
L
E
L
L
E
R
V
G
----
I
L
D
Q
-
A
-
R
-
K
Y
P
A
Q
----
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
V
M
R
D
L
-
A
Q
G
G
M
-
T
M
V
V
V
T
H
E
--
M
G
F
A
R
E
V
A
-
D
R
V
V
F
M
D
G
G
Q
I
V
E
E
G
-------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
63.44
34%
-92
- C1 -
2OLJ
4
?
A:
[39-239]
----------------------
V
L
---
K
G
I
N
---
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
---
L
R
C
L
N
----
L
L
E
------
D
F
D
E
G
E
I
I
I
D
G
I
N
L
K
-----------
A
K
D
----------
T
N
L
-
N
K
V
R
E
E
-
V
G
M
V
F
Q
R
F
N
-
L
F
P
H
M
T
V
L
N
N
I
-
T
L
A
P
M
K
V
---
R
-
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
----
L
K
D
K
-
A
-
H
-
A
Y
P
D
S
----
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
-
T
M
V
V
V
T
H
E
--
M
G
F
A
R
E
V
G
-
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
-------------------------------------------------------------------------------------------------------------------------------
37
PsiBlast_CBE
63.20
34%
-91
- C1 -
2OLK
2
?
B:
[39-239]
----------------------
V
L
---
K
G
I
N
---
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
---
L
R
C
L
N
----
L
L
E
------
D
F
D
E
G
E
I
I
I
D
G
I
N
L
K
-----------
A
K
D
----------
T
N
L
-
N
K
V
R
E
E
-
V
G
M
V
F
Q
R
F
N
-
L
F
P
H
M
T
V
L
N
N
I
-
T
L
A
P
M
K
V
---
R
-
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
----
L
K
D
K
-
A
-
H
-
A
Y
P
D
S
----
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
-
T
M
V
V
V
T
H
E
--
M
G
F
A
R
E
V
G
-
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
-------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
63.19
34%
-91
- C1 -
4YMU
2
?
J:
[16-216]
----------------------
V
L
---
K
G
V
T
---
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
---
L
R
C
I
N
----
L
L
E
------
E
P
T
K
G
E
V
F
I
D
G
V
K
I
N
----------
N
G
-
K
----------
V
N
I
-
N
K
V
R
Q
K
-
V
G
M
V
F
Q
H
F
N
-
L
F
P
H
L
T
A
I
E
N
I
-
T
L
A
P
V
K
V
---
K
-
K
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
----
L
L
D
K
-
K
-
D
-
Q
Y
P
I
K
----
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
E
-
G
M
-
T
M
V
V
V
T
H
E
--
M
G
F
A
R
E
V
G
-
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
-------------------------------------------------------------------------------------------------------------------------------
39
PsiBlast_CBE
62.44
34%
-90
- C1 -
4YMV
1
?
A:
[16-216]
----------------------
V
L
---
K
G
V
T
---
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
---
L
R
C
I
N
----
L
L
E
------
E
P
T
K
G
E
V
F
I
D
G
V
K
I
N
----------
N
G
-
K
----------
V
N
I
-
N
K
V
R
Q
K
-
V
G
M
V
F
Q
H
F
N
-
L
F
P
H
L
T
A
I
E
N
I
-
T
L
A
P
V
K
V
---
K
-
K
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
----
L
L
D
K
-
K
-
D
-
Q
Y
P
I
K
----
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
E
-
G
M
-
T
M
V
V
V
T
H
E
--
M
G
F
A
R
E
V
G
-
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
-------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
61.88
34%
-90
- C1 -
2Q0H
4
?
A:
[39-239]
----------------------
V
L
---
K
G
I
N
---
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
---
L
R
C
L
N
----
L
L
E
------
D
F
D
E
G
E
I
I
I
D
G
I
N
L
K
-----------
A
K
D
----------
T
N
L
-
N
K
V
R
E
E
-
V
G
M
V
F
Q
R
F
N
-
L
F
P
H
M
T
V
L
N
N
I
-
T
L
A
P
M
K
V
---
R
-
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
----
L
K
D
K
-
A
-
H
-
A
Y
P
D
S
----
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
-
T
M
V
V
V
T
H
E
--
M
G
F
A
R
E
V
G
-
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
-------------------------------------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
61.43
34%
-88
- C1 -
2OLK
1
?
D:
[39-239]
----------------------
V
L
---
K
G
I
N
---
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
---
L
R
C
L
N
----
L
L
E
------
D
F
D
E
G
E
I
I
I
D
G
I
N
L
K
-----------
A
K
D
----------
T
N
L
-
N
K
V
R
E
E
-
V
G
M
V
F
Q
R
F
N
-
L
F
P
H
M
T
V
L
N
N
I
-
T
L
A
P
M
K
V
---
R
-
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
----
L
K
D
K
-
A
-
H
-
A
Y
P
D
S
----
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
-
T
M
V
V
V
T
H
E
--
M
G
F
A
R
E
V
G
-
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
-------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
61.40
34%
-89
- C1 -
3C4J
4
?
B:
[39-239]
----------------------
V
L
---
K
G
I
N
---
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
---
L
R
C
L
N
----
L
L
E
------
D
F
D
E
G
E
I
I
I
D
G
I
N
L
K
-----------
A
K
D
----------
T
N
L
-
N
K
V
R
E
E
-
V
G
M
V
F
Q
R
F
N
-
L
F
P
H
M
T
V
L
N
N
I
-
T
L
A
P
M
K
V
---
R
-
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
----
L
K
D
K
-
A
-
H
-
A
Y
P
D
S
----
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
-
T
M
V
V
V
T
H
E
--
M
G
F
A
R
E
V
G
-
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
-------------------------------------------------------------------------------------------------------------------------------
41
PsiBlast_CBE
60.89
34%
-89
- C1 -
3C41
3
?
K:
[18-218]
----------------------
V
L
---
K
G
I
N
---
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
---
L
R
C
L
N
----
L
L
E
------
D
F
D
E
G
E
I
I
I
D
G
I
N
L
K
-----------
A
K
D
----------
T
N
L
-
N
K
V
R
E
E
-
V
G
M
V
F
Q
R
F
N
-
L
F
P
H
M
T
V
L
N
N
I
-
T
L
A
P
M
K
V
---
R
-
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
----
L
K
D
K
-
A
-
H
-
A
Y
P
D
S
----
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
-
T
M
V
V
V
T
H
E
--
M
G
F
A
R
E
V
G
-
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
-------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
60.85
34%
-90
- C1 -
2Q0H
4
?
B:
[39-239]
----------------------
V
L
---
K
G
I
N
---
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
---
L
R
C
L
N
----
L
L
E
------
D
F
D
E
G
E
I
I
I
D
G
I
N
L
K
-----------
A
K
D
----------
T
N
L
-
N
K
V
R
E
E
-
V
G
M
V
F
Q
R
F
N
-
L
F
P
H
M
T
V
L
N
N
I
-
T
L
A
P
M
K
V
---
R
-
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
----
L
K
D
K
-
A
-
H
-
A
Y
P
D
S
----
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
-
T
M
V
V
V
T
H
E
--
M
G
F
A
R
E
V
G
-
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
-------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
59.06
34%
-85
- C1 -
3C4J
3
?
A:
[39-239]
----------------------
V
L
---
K
G
I
N
---
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
---
L
R
C
L
N
----
L
L
E
------
D
F
D
E
G
E
I
I
I
D
G
I
N
L
K
-----------
A
K
D
----------
T
N
L
-
N
K
V
R
E
E
-
V
G
M
V
F
Q
R
F
N
-
L
F
P
H
M
T
V
L
N
N
I
-
T
L
A
P
M
K
V
---
R
-
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
----
L
K
D
K
-
A
-
H
-
A
Y
P
D
S
----
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
-
T
M
V
V
V
T
H
E
--
M
G
F
A
R
E
V
G
-
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
-------------------------------------------------------------------------------------------------------------------------------
42
PsiBlast_CBE
58.50
34%
-86
- C1 -
3C41
3
?
J:
[18-218]
----------------------
V
L
---
K
G
I
N
---
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
---
L
R
C
L
N
----
L
L
E
------
D
F
D
E
G
E
I
I
I
D
G
I
N
L
K
-----------
A
K
D
----------
T
N
L
-
N
K
V
R
E
E
-
V
G
M
V
F
Q
R
F
N
-
L
F
P
H
M
T
V
L
N
N
I
-
T
L
A
P
M
K
V
---
R
-
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
----
L
K
D
K
-
A
-
H
-
A
Y
P
D
S
----
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
-
T
M
V
V
V
T
H
E
--
M
G
F
A
R
E
V
G
-
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
-------------------------------------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
57.09
34%
-82
- C1 -
2OLJ
3
?
B:
[39-239]
----------------------
V
L
---
K
G
I
N
---
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
---
L
R
C
L
N
----
L
L
E
------
D
F
D
E
G
E
I
I
I
D
G
I
N
L
K
-----------
A
K
D
----------
T
N
L
-
N
K
V
R
E
E
-
V
G
M
V
F
Q
R
F
N
-
L
F
P
H
M
T
V
L
N
N
I
-
T
L
A
P
M
K
V
---
R
-
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
----
L
K
D
K
-
A
-
H
-
A
Y
P
D
S
----
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
-
T
M
V
V
V
T
H
E
--
M
G
F
A
R
E
V
G
-
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
-------------------------------------------------------------------------------------------------------------------------------
100
PsiBlast_CBE
53.65
31%
-94
- C1 -
2FGJ
2
D:
[8-223]
----
I
T
F
R
N
I
R
F
R
Y
K
P
D
---
S
P
V
I
L--
D
N
I
N
---
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
TKL
I
Q
R
F
Y
IPEN
G
Q
V
------
L
I
D
G
H
D
L
A
L
A
D
P
N
W
-------------------------------
L
R
R
Q
-
V
G
V
V
L
Q
D
N
V
-
L
L
N
R
S
I
I
D
-
N
I
-
S
L
-
A
N
-----
P
-
G
M
S
V
E
K
V
-
I
Y
A
A
K
L
A
G
A
H
D
FISE
L
R
E
G
-
Y
-
N
-
T
I
V
G
E
QGAG
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
-
D
Y
E
S
E
H
V
--
I
M
R
N
M
H
K
I
C
K
G
-
R
T
V
I
I
I
A
A
--
R
L
S
T
V
K
N
A
-
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
-------------------------------------------------------------------------------------------------------------------------------
95
PsiBlast_CBE
51.15
31%
-86
- C1 -
2FGK
2
D:
[8-223]
----
I
T
F
R
N
I
R
F
R
Y
K
P
D
---
S
P
V
I
L--
D
N
I
N
---
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
TKL
I
Q
R
F
Y
IPEN
G
Q
V
------
L
I
D
G
H
D
L
A
L
A
D
P
N
W
-------------------------------
L
R
R
Q
-
V
G
V
V
L
Q
D
N
V
-
L
L
N
R
S
I
I
D
-
N
I
-
S
L
-
A
N
-----
P
-
G
M
S
V
E
K
V
-
I
Y
A
A
K
L
A
G
A
H
D
FISE
L
R
E
G
-
Y
-
N
-
T
I
V
G
E
QGAG
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
-
D
Y
E
S
E
H
V
--
I
M
R
N
M
H
K
I
C
K
G
R
T
V
I
I
I
A
H
R
--
L
S
T
V
K
N
A
--
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
-------------------------------------------------------------------------------------------------------------------------------
97
PsiBlast_CBE
49.21
31%
-85
- C1 -
2FGK
2
HLYBP_ECOLX
B:
[8-223]
----
I
T
F
R
N
I
R
F
R
Y
K
P
D
---
S
P
V
I
L--
D
N
I
N
---
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
TKL
I
Q
R
F
Y
IPEN
G
Q
V
------
L
I
D
G
H
D
L
A
L
A
D
P
N
W
-------------------------------
L
R
R
Q
-
V
G
V
V
L
Q
D
N
V
-
L
L
N
R
S
I
I
D
-
N
I
-
S
L
-
A
N
-----
P
-
G
M
S
V
E
K
V
-
I
Y
A
A
K
L
A
G
A
H
D
FISE
L
R
E
G
-
Y
-
N
-
T
I
V
G
E
QGAG
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
-
D
Y
E
S
E
H
V
--
I
M
R
N
M
H
K
I
C
K
G
R
T
V
I
I
I
A
H
R
--
L
S
T
V
K
N
A
--
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
-------------------------------------------------------------------------------------------------------------------------------
98
PsiBlast_CBE
49.06
31%
-85
- C1 -
2FGK
2
HLYBP_ECOLX
A:
[8-223]
----
I
T
F
R
N
I
R
F
R
Y
K
P
D
---
S
P
V
I
L--
D
N
I
N
---
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
IPE
N
G
Q
V
------
L
I
D
G
H
D
L
A
L
A
D
P
N
W
-------------------------------
L
R
R
Q
-
V
G
V
V
L
Q
D
N
V
-
L
L
N
R
S
I
I
D
-
N
I
-
S
L
-
A
N
-----
P
-
G
M
S
V
E
K
V
-
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
-
Y
-
N
-
T
I
V
G
E
QGAG
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
-
D
Y
E
S
E
H
V
--
I
M
R
N
M
H
K
I
C
K
G
R
T
V
I
I
I
A
H
R
--
L
S
T
V
K
N
A
--
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
-------------------------------------------------------------------------------------------------------------------------------
96
PsiBlast_CBE
48.69
31%
-86
- C1 -
2FGK
2
HLYBP_ECOLX
C:
[8-223]
----
I
T
F
R
N
I
R
F
R
Y
K
P
D
---
S
P
V
I
L--
D
N
I
N
---
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
TKL
I
Q
R
F
Y
IPEN
G
Q
V
------
L
I
D
G
H
D
L
A
L
A
D
P
N
W
-------------------------------
L
R
R
Q
-
V
G
V
V
L
Q
D
N
V
-
L
L
N
R
S
I
I
D
-
N
I
-
S
L
-
A
N
-----
P
-
G
M
S
V
E
K
V
-
I
Y
A
A
K
L
A
G
A
H
D
FISE
L
R
E
G
-
Y
-
N
-
T
I
V
G
E
QGAG
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
-
D
Y
E
S
E
H
V
--
I
M
R
N
M
H
K
I
C
K
G
R
T
V
I
I
I
A
H
R
--
L
S
T
V
K
N
A
--
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
-------------------------------------------------------------------------------------------------------------------------------
91
PsiBlast_CBE
48.30
32%
-79
- C1 -
2FF7
1
A:
[8-223]
----
I
T
F
R
N
I
R
F
R
Y
K
P
D
---
S
P
V
I
L--
D
N
I
N
---
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
IPE
N
G
Q
V
------
L
I
D
G
H
D
L
A
L
A
D
P
N
W
-------------------------------
L
R
R
Q
-
V
G
V
V
L
Q
D
N
V
-
L
L
N
R
S
I
I
D
-
N
I
-
S
L
-
A
N
-----
P
-
G
M
S
V
E
K
V
-
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
-
Y
-
N
-
T
I
V
G
E
QGAG
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
-
D
Y
E
S
E
H
V
--
I
M
R
N
M
H
K
I
C
K
G
R
T
V
I
I
I
A
H
R
--
L
S
T
V
K
N
A
--
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
-------------------------------------------------------------------------------------------------------------------------------
99
PsiBlast_CBE
47.40
31%
-76
- C1 -
2FFB
1
A:
[8-223]
----
I
T
F
R
N
I
R
F
R
Y
K
P
D
---
S
P
V
I
L--
D
N
I
N
---
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
IPE
N
G
Q
V
------
L
I
D
G
H
D
L
A
L
A
D
P
N
W
-------------------------------
L
R
R
Q
-
V
G
V
V
L
Q
D
N
V
-
L
L
N
R
S
I
I
D
-
N
I
-
S
L
-
A
N
-----
P
-
G
M
S
V
E
K
V
-
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
-
Y
-
N
-
T
I
V
G
E
QG
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
-
D
Y
E
S
E
H
V
--
I
M
R
N
M
H
K
I
C
K
G
R
T
V
I
I
I
A
H
R
--
L
S
T
V
K
N
A
--
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
-------------------------------------------------------------------------------------------------------------------------------
93
PsiBlast_CBE
47.21
32%
-79
- C1 -
2PMK
1
A:
[4-219]
----
I
T
F
R
N
I
R
F
R
Y
K
P
D
---
S
P
V
I
L--
D
N
I
N
---
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
IPE
N
G
Q
V
------
L
I
D
G
H
D
L
A
L
A
D
P
N
W
-------------------------------
L
R
R
Q
-
V
G
V
V
L
Q
D
N
V
-
L
L
N
R
S
I
I
D
-
N
I
-
S
L
-
A
N
-----
P
-
G
M
S
V
E
K
V
-
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
-
Y
-
N
-
T
I
V
G
E
QGAG
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
-
D
Y
E
S
E
H
V
--
I
M
R
N
M
H
K
I
C
K
G
R
T
V
I
I
I
A
H
R
--
L
S
T
V
K
N
A
--
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
-------------------------------------------------------------------------------------------------------------------------------
94
PsiBlast_CBE
45.19
31%
-78
- C1 -
3B5J
1
A:
[4-219]
----
I
T
F
R
N
I
R
F
R
Y
K
P
D
---
S
P
V
I
L--
D
N
I
N
---
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
A
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
IPE
N
G
Q
V
------
L
I
D
G
H
D
L
A
L
A
D
P
N
W
-------------------------------
L
R
R
Q
-
V
G
V
V
L
Q
D
N
V
-
L
L
N
R
S
I
I
D
-
N
I
-
S
L
-
A
N
-----
P
-
G
M
S
V
E
K
V
-
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
-
Y
-
N
-
T
I
V
G
E
QG
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
-
D
Y
E
S
E
H
V
--
I
M
R
N
M
H
K
I
C
K
G
R
T
V
I
I
I
A
H
R
--
L
S
T
V
K
N
A
--
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
-------------------------------------------------------------------------------------------------------------------------------