@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_0723: (2015-12-17 )
MIKAIIGKIIGTRNDRWIKQYKKKVLAINALEPTYEKMSDVELQNAFEELKKRVRSVEKDLQEKTLLEVLPESFAITREASKRILKMRHFDVQLIGGMVLNDGKIAEMKTGEGKTLVATLAVALNAMKGESVYVVTVNDYLAHRDSKEMEPLYQFLGYSVGTITASVRDDDERLEIYSKDIVYGTNNEFGFDYLRDNMKYSLEHKVQKSHAFAIVDEVDSILIDEARTPLIISGPVDRRMENYNKADEVAKSMQVEVDFTIDEKNRAILITEEGIKKAENLFGVDNLYKIENAALSHHLDQALKANYLFFIDKDYIVANNEVVIVDEFTGRLSEGRRFSEGLHQALEAKEGVSIKEESQTLADITFQNYFRMFSKLSGMTGTAQTEATEFLEIYNLEVVSIPTNLAIKRKDLNDLIYKSEKEKFDAVILKIKELHDKGQPVLVGTASIEKSETLHALLKKERIPHTVLNAKQHTKEAEIIKDAGLKGAVTIATNMAGRGVDIKLTDEVKELGGLYIIGTERHESRRIDNQLRGRSGRQGDPGVSQFYLSLEDNLLRIFGSDRIKGVMEKLGLKDGEHIESKLVTRAVENAQKKVENLHFESRKHLLEYDDVANEQRKSVYKFRDELLDINYDISAKIAENREYALNQIFSKLKAFDHQNLSEEELLGLKNILKEDFNASVELEDLEKASPIEKFVAEKLKSDYENKMKALDSEQRSRIERIVYLQILDNAWREHLYTMDNLKTGINLRGYNQKDPLVEYKKESYNLFLELIGDIKIEAIQTFSKIQFENEQDSSDAERYLDNFSEEREHESVTYRHEEALDEDLNVAVKAFSKTPKRNEPCPCGSGKKYKDCCAKSGPKKGLFAK
Atome Classification :
(23 SA)
.........10........-20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160...-----------------------....170-------------------------........180.......190.......200....---..---.210.......220.......230.......240.......-----------250.------------..------------....260.......270.......280---..----.....290.......300.......310.......320.......330.......340....----------...350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......----------------------------------------------------------------------------460--------------------------------------------------------------------------.........470.......480.......490.......500.-------.------------------------------------------------------------------.-----------------------------.------------------------------------------------------------------...-----------------------------------------510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620--------.....-..-----..630-.-...-.--..640...----.....650.----..-....660-.-...---...670....--...680--...------....690-----..--.....--..700.......----710.....-..720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
I
K
A
I
I
G
K
I
IGTR
N
D
R
W
I
K
-
Q
Y
K
K
K
V
L
A
I
NALE
P
T
Y
E
K
M
S
D
V
E
L
Q
N
A
F
E
E
L
K
K
R
V
R
S
V
E
K
D
L
Q
E
K
T
L
L
E
V
L
P
E
S
FA
I
T
R
E
A
S
K
R
I
L
K
M
RH
F
D
V
Q
L
I
G
G
M
V
LNDG
K
I
A
E
M
KTGEG
K
T
L
V
A
T
L
A
V
A
L
N
AMKGE
S
V
Y
V
V
T
V
N
D
Y
LAHRDS
K
E
M
E
P
L
Y
Q
F
LGYS
V
G
T
I
T
A
-----------------------SVRD
D
D
--------------------------
E
R
L
E
I
Y
S
K
D
I
V
Y
GTNNEF
G
F
D
Y
L
R
DNM
K
Y
S
L
E
H
K
V---QK---SH
A
F
A
I
V
D
E
V
D
S
I
L
IDEART
P
L
I
I
SGP
V
D
R
R
M
E
NY
N
K
A
D
E
V
-----------
A
KS
M
------------
Q
V
------------
E
V
D
F
T
IDEKN
R
A
I
L
I
T
E
E
G
I
K
K
A
E
N
LF---GV----
D
N
L
Y
K
I
E
N
A
A
L
S
H
H
L
D
Q
A
LKA
N
Y
L
F
F
IDK
D
Y
I
V
ANN
E
V
V
I
V
DEFT
G
R
L
SEG
R
R
F
S
E
G
L
H
Q
A
L
----------
E
AKEGVSI
K
E
E
S
Q
T
L
A
D
I
T
F
Q
N
Y
F
R
M
F
S
K
LSGMTGTA
Q
T
E
A
T
E
F
L
E
I
Y
N
L
E
V
V
SIPTN
L
A
I
KRK
D
L
N
D
L
I
Y
K
S
E
K
E
K
F
D
A
V
I
L
K
I
K
E
L
HDKGQ
P
V
L
V
G
TASIE
K
S
E
T
L
H
A
L
L
K
----------------------------------------------------------------------------K----------------------------------------------------------------------------ERI
P
H
T
V
LN
A
K
QH
T
K
E
A
E
I
I
K
DAGLK
G
A
V
T
I
A
TNMAGRG
V
D
I
K
-------L------------------------------------------------------------------
T
-----------------------------
D
------------------------------------------------------------------
E
V
K
-----------------------------------------ELG
G
L
Y
I
I
GTER
H
E
S
R
R
I
D
N
Q
LRGRSGRQGDP
G
V
S
Q
F
Y
L
S
LED
N
L
L
R
I
FG
S
D
R
I
K
G
V
M
E
KLGLKD
G
E
H
I
E
S
K
L
V
T
R
A
V
E
N
A
Q
K
K
V
E
NL
H
F
E
S
R
K
H
L
L
E
Y
D
D
V
A
N
E
Q
R
K
S
V
Y
----------
K
F
R
D
E
-
L
L-----DINYD-
I
-
S
A
K
-I--AEN-
R
E
Y
A
----
L
N
Q
I
F
S
K
L
K
----
A
F-DHQNL
S
E
-
E
-
E
L
L
---
G
L
K
N
I
L
K
E
DF--NA
S
V
E
L
--
E
D
L
------EKAS
P
-------
I
E
--
K
F
V
A
E
--
K
L
K
S
D
Y
E
N
K
M
K
A----L
D
S
E
Q
R
S
R
-
I
E
R
I
V
Y
L
Q
I
L
D
N
A
W
R
E
H
L
Y
T
M
D
NLKTGINLRGYNQKD
P
L
V
E
Y
K
K
E
S
Y
N
L
F
L
E
L
I
GDI
K
I
E
A
I
Q
T
F
S
K
I
Q
FENEQDS
S
D
A
E
R
Y
L
D
N
F
S
E
E
R
E
HESV
T
Y
R
H
E
E
A
L
D
E
D
L
N
V
A
V
K
A
F
SKTPKRNEPCPCGSG
K
K
Y
K
D
C
C
AKSGPKKGLFAK
33
HHSearch
86.43
52%
-64
- C3 -
2FSF
-
SECA_ECOLI
A:
[13-834]
------------
R
N
D
R
T
L
R
-
R
M
R
K
V
V
N
I
I
N
A
M
E
P
E
M
E
K
L
S
D
E
E
L
K
G
K
T
A
E
F
R
A
R
L
E
K
G
------
E
V
L
E
N
L
I
P
E
A
F
A
V
V
R
E
A
S
K
R
V
F
G
M
R
H
F
D
V
Q
L
L
G
G
M
V
L
N
E
R
C
I
A
E
M
R
T
G
E
G
K
T
L
T
A
T
L
P
A
Y
L
N
A
L
T
G
K
G
V
H
V
V
T
V
N
D
Y
L
A
Q
R
D
A
E
N
N
R
P
L
F
E
F
L
G
L
T
V
G
I
N
L
P
-----------------------
G
M
P
-
A
P
--------------------------
A
K
R
E
A
Y
A
A
D
I
T
Y
G
T
N
N
E
Y
G
F
D
Y
L
R
D
N
M
A
F
S
P
E
E
R
V
---
Q
R
---
K
L
H
Y
A
L
V
D
E
V
D
S
I
L
I
D
E
A
R
T
P
L
I
I
S
G
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
Q
N
E
N
Q
T
L
A
S
I
T
F
Q
N
Y
F
R
L
Y
E
K
L
A
G
M
T
G
T
A
D
T
E
A
F
E
F
S
S
I
Y
K
L
D
T
V
V
V
P
T
N
R
P
M
I
R
K
D
L
P
D
L
V
Y
M
T
E
A
E
K
I
Q
A
I
I
E
D
I
K
E
R
T
A
K
G
Q
P
V
L
V
G
T
I
S
I
E
K
S
E
L
V
S
N
E
L
T
----------------------------------------------------------------------------
K
----------------------------------------------------------------------------
A
G
I
K
H
N
V
L
N
A
K
F
H
A
N
E
A
A
I
V
A
Q
A
G
Y
P
A
A
V
T
I
A
T
N
M
A
G
R
G
T
D
I
V
-------
L
------------------------------------------------------------------
G
-----------------------------
G
S
W
Q
A
E
V
A
A
LENPT
A
E
Q
I
E
K
I
K
A
D
W
Q
V
R
H
D
-------------------------------------
A
V
L
-----------------------------------------
E
A
G
G
L
H
I
I
G
T
E
R
H
E
S
R
R
I
D
N
Q
L
R
G
R
S
G
R
Q
G
D
A
G
S
S
R
F
Y
L
S
M
E
D
A
L
M
R
I
F
A
S
D
R
V
S
G
M
M
R
K
L
G
M
K
P
G
E
A
I
E
H
P
W
V
T
K
A
I
A
N
A
Q
R
K
V
E
S
R
N
F
D
I
R
K
Q
L
L
E
Y
D
D
V
A
N
D
Q
R
R
A
I
Y
----------
S
Q
R
N
E
-
L
L
-----
D
V
S
D
--
V
-
S
E
T
-
I
--
N
S
I
-
R
E
D
V
----
F
K
A
T
I
D
A
Y
I
----
P
P
--
Q
S
L
E
E
M
-
W
-
D
I
P
---
G
L
Q
E
R
L
K
N
D
F
--
D
L
D
L
P
I
--
A
E
W
L
D
K
E
PE
L
H
E
E
T
-------
L
R
--
E
R
I
L
A
--
Q
S
I
E
V
Y
Q
R
K
E
E
V
----
V
G
A
E
M
M
R
H
-
F
E
K
G
V
M
L
Q
T
L
D
S
L
W
K
E
H
L
A
A
M
D
Y
L
R
Q
G
I
H
L
R
G
Y
A
Q
K
D
P
K
Q
E
Y
K
R
E
S
F
S
M
F
A
A
M
L
E
S
L
K
Y
E
V
I
S
T
L
S
K
V
Q
V
R
M
P
---------------------------------------------------------------------------
21
PsiBlast_CBE
86.29
50%
-64
- C3 -
2FSI
1
SECA_ECOLI
B:
[3-822]
----------
G
S
R
N
D
R
T
L
R
-
R
M
R
K
V
V
N
I
I
N
A
M
E
P
E
M
E
K
L
S
D
E
E
L
K
G
K
T
A
E
F
R
A
R
L
E
K
G
E
------
V
L
E
N
L
I
P
E
A
F
A
V
V
R
E
A
S
K
R
V
F
G
M
R
H
F
D
V
Q
L
L
G
G
M
V
L
N
E
R
C
I
A
E
M
R
T
G
E
G
K
T
L
T
A
T
L
P
A
Y
L
N
A
L
T
G
K
G
V
H
V
V
T
V
N
D
Y
L
A
Q
R
D
A
E
N
N
R
P
L
F
E
F
L
G
L
T
V
G
I
N
L
P
-----------------------
G
M
P
A
P
A
--------------------------
K
R
-
E
A
Y
A
A
D
I
T
Y
G
T
N
N
E
Y
G
F
D
Y
L
R
D
N
M
A
F
S
P
E
E
R
V
---
Q
R
---
K
L
H
Y
A
L
V
D
E
V
D
S
I
L
I
D
E
A
R
T
P
L
I
I
S
G
P
A
E
D
S
S
E
M
Y
K
R
V
N
K
I
I
P
H
LIRQ------------------------------------------------------
V
L
I
E
E
L
L
VKE
G
I
MDEG
E
S
L
Y
S
P
A
N
I
M
L
M
H
H
V
T
A
A
L
R
A
H
A
----------------------------------------------------------
N
E
N
Q
T
L
A
S
I
T
F
Q
N
Y
F
R
L
Y
E
K
L
A
G
M
T
G
T
A
D
T
E
A
F
E
F
S
S
I
Y
K
L
D
T
V
V
V
P
T
N
R
P
M
I
R
K
D
L
P
D
L
V
Y
M
T
E
A
E
K
I
Q
A
I
I
E
D
I
K
E
R
T
A
K
G
Q
P
V
L
V
G
T
I
S
I
E
K
S
E
L
V
S
N
E
L
T
----------------------------------------------------------------------------
K
----------------------------------------------------------------------------
A
G
I
K
H
N
V
L
N
A
K
F
H
A
N
E
A
A
I
V
A
Q
A
G
Y
P
A
A
V
T
I
A
T
N
M
A
G
R
G
T
D
I
V
-------
L
------------------------------------------------------------------
G
GS
W
Q
A
E
V
A
ALENPT
A
E
Q
I
E
K
I
K
A
D
W
Q
V
R
H
D
------------------------------------------------------------------
A
V
L
-----------------------------------------
E
A
G
G
L
H
I
I
G
T
E
R
H
E
S
R
R
I
D
N
Q
L
R
G
R
S
G
R
Q
G
D
A
G
S
S
R
F
Y
L
S
M
E
D
A
L
M
R
I
F
A
S
D
R
V
S
G
M
M
R
K
L
G
M
K
P
G
E
A
I
E
H
P
W
V
T
K
A
I
A
N
A
Q
R
K
V
E
S
R
N
F
D
I
R
K
Q
L
L
E
Y
D
D
V
A
N
D
Q
R
R
A
I
Y
----------
S
Q
R
N
E
-
L
L
-----
D
V
S
-
D
-
V
-
S
E
T
-
I
--
N
S
I
-
R
E
D
V
----
F
K
A
T
I
D
A
Y
------
I
-
P
P
Q
S
L
E
E
M
W
-
D
I
P
---
G
L
Q
E
R
L
K
N
D
F
--
D
L
D
L
P
I
--
A
E
W
------
L
D
K
E
P
ELH
E
E
T
L
R
E
--
R
I
L
A
Q
--
S
I
E
V
-
Y
Q
R
K
E
E
V
----
V
G
A
E
M
M
R
H
-
F
E
K
G
V
M
L
Q
T
L
D
S
L
W
K
E
H
L
A
A
M
D
Y
L
R
Q
G
I
H
L
R
G
Y
A
Q
K
D
P
K
Q
E
Y
K
R
E
S
F
S
M
F
A
A
M
L
E
S
L
K
Y
E
V
I
S
T
L
S
K
V
Q
V
R
M
P
E
E
-------------------------------------------------------------------------
3
PsiBlast_PDB
85.88
50%
-61
- C3 -
2FSI
1
SECA_ECOLI
A:
[5-822]
------------
R
N
D
R
T
L
R
-
R
M
R
K
V
V
N
I
I
N
A
M
E
P
E
M
E
K
L
S
D
E
E
L
K
G
K
T
A
E
F
R
A
R
L
E
K
G
E
------
V
L
E
N
L
I
P
E
A
F
A
V
V
R
E
A
S
K
R
V
F
G
M
R
H
F
D
V
Q
L
L
G
G
M
V
L
N
E
R
C
I
A
E
M
R
T
G
E
G
K
T
L
T
A
T
L
P
A
Y
L
N
A
L
T
G
K
G
V
H
V
V
T
V
N
D
Y
L
A
Q
R
D
A
E
N
N
R
P
L
F
E
F
L
G
L
T
V
G
I
N
L
P
-----------------------
G
M
P
A
P
A
--------------------------
K
R
-
E
A
Y
A
A
D
I
T
Y
G
T
N
N
E
Y
G
F
D
Y
L
R
D
N
M
A
F
S
P
E
E
R
V
---
Q
R
---
K
L
H
Y
A
L
V
D
E
V
D
S
I
L
I
D
E
A
R
T
P
L
I
I
S
G
P
A
E
D
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
N
E
N
Q
T
L
A
S
I
T
F
Q
N
Y
F
R
L
Y
E
K
L
A
G
M
T
G
T
A
D
T
E
A
F
E
F
S
S
I
Y
K
L
D
T
V
V
V
P
T
N
R
P
M
I
R
K
D
L
P
D
L
V
Y
M
T
E
A
E
K
I
Q
A
I
I
E
D
I
K
E
R
T
A
K
G
Q
P
V
L
V
G
T
I
S
I
E
K
S
E
L
V
S
N
E
L
T
----------------------------------------------------------------------------
K
----------------------------------------------------------------------------
A
G
I
K
H
N
V
L
N
A
K
F
H
A
N
E
A
A
I
V
A
Q
A
G
Y
P
A
A
V
T
I
A
T
N
M
A
G
R
G
T
D
I
V
-------
L
------------------------------------------------------------------
G
GS
W
Q
A
E
V
A
A
LENPT
A
E
Q
I
E
K
I
K
A
D
W
Q
V
R
H
D
------------------------------------------------------------------
A
V
L
-----------------------------------------
E
A
G
G
L
H
I
I
G
T
E
R
H
E
S
R
R
I
D
N
Q
L
R
G
R
S
G
R
Q
G
D
A
G
S
S
R
F
Y
L
S
M
E
D
A
L
M
R
I
F
A
S
D
R
V
S
G
M
M
R
K
L
G
M
K
P
G
E
A
I
E
H
P
W
V
T
K
A
I
A
N
A
Q
R
K
V
E
S
R
N
F
D
I
R
K
Q
L
L
E
Y
D
D
V
A
N
D
Q
R
R
A
I
Y
----------
S
Q
R
N
E
-
L
L
-----
D
V
S
-
D
-
V
-
S
E
T
-
I
--
N
S
I
-
R
E
D
V
----
F
K
A
T
I
D
A
Y
------
I
-
P
P
Q
S
L
E
E
M
W
-
D
I
P
---
G
L
Q
E
R
L
K
N
D
F
--
D
L
D
L
P
I
--
A
E
W
------
L
D
K
E
P
ELH
E
E
T
L
R
E
--
R
I
L
A
Q
--
S
I
E
V
-
Y
Q
R
K
E
E
V
----
V
G
A
E
M
M
R
H
-
F
E
K
G
V
M
L
Q
T
L
D
S
L
W
K
E
H
L
A
A
M
D
Y
L
R
Q
G
I
H
L
R
G
Y
A
Q
K
D
P
K
Q
E
Y
K
R
E
S
F
S
M
F
A
A
M
L
E
S
L
K
Y
E
V
I
S
T
L
S
K
V
Q
V
R
M
P
E
E
-------------------------------------------------------------------------
2
PsiBlast_PDB
85.85
50%
-62
- C3 -
2FSH
1
SECA_ECOLI
A:
[5-822]
------------
R
N
D
R
T
L
R
-
R
M
R
K
V
V
N
I
I
N
A
M
E
P
E
M
E
K
L
S
D
E
E
L
K
G
K
T
A
E
F
R
A
R
L
E
K
G
E
------
V
L
E
N
L
I
P
E
A
F
A
V
V
R
E
A
S
K
R
V
F
G
M
R
H
F
D
V
Q
L
L
G
G
M
V
L
N
E
R
C
I
A
E
M
R
T
G
E
G
K
T
L
T
A
T
L
P
A
Y
L
N
A
L
T
G
K
G
V
H
V
V
T
V
N
D
Y
L
A
Q
R
D
A
E
N
N
R
P
L
F
E
F
L
G
L
T
V
G
I
N
L
P
-----------------------
G
M
P
A
P
A
--------------------------
K
R
-
E
A
Y
A
A
D
I
T
Y
G
T
N
N
E
Y
G
F
D
Y
L
R
D
N
M
A
F
S
P
E
E
R
V
---
Q
R
---
K
L
H
Y
A
L
V
D
E
V
D
S
I
L
I
D
E
A
R
T
P
L
I
I
S
G
P
A
E
D
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
N
E
N
Q
T
L
A
S
I
T
F
Q
N
Y
F
R
L
Y
E
K
L
A
G
M
T
G
T
A
D
T
E
A
F
E
F
S
S
I
Y
K
L
D
T
V
V
V
P
T
N
R
P
M
I
R
K
D
L
P
D
L
V
Y
M
T
E
A
E
K
I
Q
A
I
I
E
D
I
K
E
R
T
A
K
G
Q
P
V
L
V
G
T
I
S
I
E
K
S
E
L
V
S
N
E
L
T
----------------------------------------------------------------------------
K
----------------------------------------------------------------------------
A
G
I
K
H
N
V
L
N
A
K
F
H
A
N
E
A
A
I
V
A
Q
A
G
Y
P
A
A
V
T
I
A
T
N
M
A
G
R
G
T
D
I
V
-------
L
------------------------------------------------------------------
G
GS
W
Q
A
E
V
A
A
LENPT
A
E
Q
I
E
K
I
K
A
D
W
Q
V
R
H
D
------------------------------------------------------------------
A
V
L
-----------------------------------------
E
A
G
G
L
H
I
I
G
T
E
R
H
E
S
R
R
I
D
N
Q
L
R
G
R
S
G
R
Q
G
D
A
G
S
S
R
F
Y
L
S
M
E
D
A
L
M
R
I
F
A
S
D
R
V
S
G
M
M
R
K
L
G
M
K
P
G
E
A
I
E
H
P
W
V
T
K
A
I
A
N
A
Q
R
K
V
E
S
R
N
F
D
I
R
K
Q
L
L
E
Y
D
D
V
A
N
D
Q
R
R
A
I
Y
----------
S
Q
R
N
E
-
L
L
-----
D
V
S
-
D
-
V
-
S
E
T
-
I
--
N
S
I
-
R
E
D
V
----
F
K
A
T
I
D
A
Y
------
I
-
P
P
Q
S
L
E
E
M
W
-
D
I
P
---
G
L
Q
E
R
L
K
N
D
F
--
D
L
D
L
P
I
--
A
E
W
------
L
D
K
E
P
ELH
E
E
T
L
R
E
--
R
I
L
A
Q
--
S
I
E
V
-
Y
Q
R
K
E
E
V
----
V
G
A
E
M
M
R
H
-
F
E
K
G
V
M
L
Q
T
L
D
S
L
W
K
E
H
L
A
A
M
D
Y
L
R
Q
G
I
H
L
R
G
Y
A
Q
K
D
P
K
Q
E
Y
K
R
E
S
F
S
M
F
A
A
M
L
E
S
L
K
Y
E
V
I
S
T
L
S
K
V
Q
V
R
M
P
E
E
-------------------------------------------------------------------------
1
PsiBlast_PDB
85.80
50%
-63
- C3 -
2FSF
-
SECA_ECOLI
A:
[13-830]
------------
R
N
D
R
T
L
R
-
R
M
R
K
V
V
N
I
I
N
A
M
E
P
E
M
E
K
L
S
D
E
E
L
K
G
K
T
A
E
F
R
A
R
L
E
K
G
E
------
V
L
E
N
L
I
P
E
A
F
A
V
V
R
E
A
S
K
R
V
F
G
M
R
H
F
D
V
Q
L
L
G
G
M
V
L
N
E
R
C
I
A
E
M
R
T
G
E
G
K
T
L
T
A
T
L
P
A
Y
L
N
A
L
T
G
K
G
V
H
V
V
T
V
N
D
Y
L
A
Q
R
D
A
E
N
N
R
P
L
F
E
F
L
G
L
T
V
G
I
N
L
P
-----------------------
G
M
P
A
P
A
--------------------------
K
R
-
E
A
Y
A
A
D
I
T
Y
G
T
N
N
E
Y
G
F
D
Y
L
R
D
N
M
A
F
S
P
E
E
R
V
---
Q
R
---
K
L
H
Y
A
L
V
D
E
V
D
S
I
L
I
D
E
A
R
T
P
L
I
I
S
G
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
Q
N
E
N
Q
T
L
A
S
I
T
F
Q
N
Y
F
R
L
Y
E
K
L
A
G
M
T
G
T
A
D
T
E
A
F
E
F
S
S
I
Y
K
L
D
T
V
V
V
P
T
N
R
P
M
I
R
K
D
L
P
D
L
V
Y
M
T
E
A
E
K
I
Q
A
I
I
E
D
I
K
E
R
T
A
K
G
Q
P
V
L
V
G
T
I
S
I
E
K
S
E
L
V
S
N
E
L
T
----------------------------------------------------------------------------
K
----------------------------------------------------------------------------
A
G
I
K
H
N
V
L
N
A
K
F
H
A
N
E
A
A
I
V
A
Q
A
G
Y
P
A
A
V
T
I
A
T
N
M
A
G
R
G
T
D
I
V
-------
L
------------------------------------------------------------------
G
GS
W
Q
A
E
V
A
A
LENPT
A
E
Q
I
E
K
I
K
A
D
W
Q
V
R
H
D
------------------------------------------------------------------
A
V
L
-----------------------------------------
E
A
G
G
L
H
I
I
G
T
E
R
H
E
S
R
R
I
D
N
Q
L
R
G
R
S
G
R
Q
G
D
A
G
S
S
R
F
Y
L
S
M
E
D
A
L
M
R
I
F
A
S
D
R
V
S
G
M
M
R
K
L
G
M
K
P
G
E
A
I
E
H
P
W
V
T
K
A
I
A
N
A
Q
R
K
V
E
S
R
N
F
D
I
R
K
Q
L
L
E
Y
D
D
V
A
N
D
Q
R
R
A
I
Y
----------
S
Q
R
N
E
-
L
L
-----
D
V
S
-
D
-
V
-
S
E
T
-
I
--
N
S
I
-
R
E
D
V
----
F
K
A
T
I
D
A
Y
------
I
-
P
P
Q
S
L
E
E
M
W
-
D
I
P
---
G
L
Q
E
R
L
K
N
D
F
--
D
L
D
L
P
I
--
A
E
W
------
L
D
K
E
P
ELH
E
E
T
L
R
E
--
R
I
L
A
Q
--
S
I
E
V
-
Y
Q
R
K
E
E
V
----
V
G
A
E
M
M
R
H
-
F
E
K
G
V
M
L
Q
T
L
D
S
L
W
K
E
H
L
A
A
M
D
Y
L
R
Q
G
I
H
L
R
G
Y
A
Q
K
D
P
K
Q
E
Y
K
R
E
S
F
S
M
F
A
A
M
L
E
S
L
K
Y
E
V
I
S
T
L
S
K
V
Q
V
R
M
P
---------------------------------------------------------------------------
32
HHSearch
85.11
48%
-59
- C3 -
1NKT
2
SECA1_MYCTU
A:
[27-865]
S
M
A
D
I
L
S
K
L
L
R
L
G
E
G
R
M
V
K
-
R
L
K
K
V
A
D
Y
V
G
T
L
S
D
D
V
E
K
L
T
D
A
E
L
R
A
K
T
D
E
F
K
R
R
L
A
D
Q
---
K
N
P
E
T
L
D
D
L
L
P
E
A
F
A
V
A
R
E
A
A
W
R
V
L
D
Q
R
P
F
D
V
Q
V
M
G
A
A
A
L
H
L
G
N
V
A
E
M
K
T
G
E
G
K
T
L
T
C
V
L
P
A
Y
L
N
A
L
A
G
N
G
V
H
I
V
T
V
N
D
Y
L
A
K
R
D
S
E
W
M
G
R
V
H
R
F
L
G
L
Q
V
G
V
I
L
A
-----------------------
T
M
T
-
P
D
--------------------------
E
R
R
V
A
Y
N
A
D
I
T
Y
G
T
N
N
E
F
G
F
D
Y
L
R
D
N
M
A
H
S
L
D
D
L
V
---
Q
R
---
G
H
H
Y
A
I
V
D
E
V
D
S
I
L
I
D
E
A
R
T
P
L
I
I
S
G
P
A
D
G
A
S
N
W
Y
T
E
F
A
R
L
-----------
A
P
L
M
------------
E
K
------------
D
V
H
Y
E
V
D
L
R
K
R
T
V
G
V
H
E
K
G
V
E
F
V
E
D
Q
L
---
G
I
----
D
N
L
Y
E
A
A
N
S
P
L
V
S
Y
L
N
N
A
L
K
A
K
E
L
F
S
R
D
K
D
Y
I
V
R
D
G
E
V
L
I
V
D
E
F
T
G
R
V
L
I
G
R
R
Y
N
E
G
M
H
Q
A
I
----------
E
A
K
E
H
V
E
I
K
A
E
N
Q
T
L
A
T
I
T
L
Q
N
Y
F
R
L
Y
D
K
L
A
G
M
T
G
T
A
Q
T
E
A
A
E
L
H
E
I
Y
K
L
G
V
V
S
I
P
T
N
M
P
M
I
R
E
D
Q
S
D
L
I
Y
K
T
E
E
A
K
Y
I
A
V
V
D
D
V
A
E
R
Y
A
K
G
Q
P
V
L
I
G
T
T
S
V
E
R
S
E
Y
L
S
R
Q
F
T
----------------------------------------------------------------------------
K
----------------------------------------------------------------------------
R
R
I
P
H
N
V
L
N
A
K
Y
H
E
Q
E
A
T
I
I
A
V
A
G
R
R
G
G
V
T
V
A
T
N
M
A
G
R
G
T
D
I
V
LGG----
N
------------------------------------------------------------------
V
-----------------------------
D
------------------------------------------------------------------
F
L
T
D
Q
R
L
R
E
R
GLDPVET
P
E
E
Y
E
A
A
W
H
S
E
L
P
I
V
K
E
E
A
S
K
E
A
K
E
V
I
E
A
G
G
L
Y
V
L
G
T
E
R
H
E
S
R
R
I
D
N
Q
L
R
G
R
S
G
R
Q
G
D
P
G
E
S
R
F
Y
L
S
L
G
D
E
L
M
R
R
F
N
G
A
A
L
E
T
L
L
T
R
L
N
L
P
D
D
V
P
I
E
A
K
M
V
T
R
A
I
K
S
A
Q
T
Q
V
E
Q
Q
N
F
E
V
R
K
N
V
L
K
Y
D
E
V
M
N
Q
Q
R
K
V
I
Y
----------
A
E
R
R
R
-
I
L
-----
E
G
E
N
--
L
-
K
D
Q
-
A
--
L
D
M
-
V
R
D
V
----
I
T
A
Y
V
D
G
A
T
----
G
E
---
G
Y
A
E
D
-
W
-
D
L
D
---
A
L
W
T
A
L
K
T
L
Y
--
P
V
G
I
T
A
--
D
S
L
T-----------------
L
L
--
E
A
L
L
K
--
D
A
E
R
A
Y
A
A
R
E
A
E
L
E
E
I
A
G
E
G
A
M
R
Q
-
L
E
R
N
V
L
L
N
V
I
D
R
K
W
R
E
H
L
Y
E
M
D
Y
L
K
E
G
I
G
L
R
A
M
A
Q
R
D
P
L
V
E
Y
Q
R
E
G
Y
D
M
F
M
A
M
L
D
G
M
K
E
E
S
V
G
F
L
F
N
V
T
V
------------------------------------------------------------------------------
52
Fugue
84.95
50%
-46
- C3 -
2IPC
-
SECA_THET8
A:
[1-939]
-
M
L
G
L
L
R
R
L
F
D
N
N
E
R
E
I
A
R
-
Y
Y
K
Q
V
V
E
P
V
N
R
L
E
A
E
V
E
K
L
P
D
--
L
A
A
A
Y
R
E
L
K
E
K
H
E
------
K
G
A
S
L
D
E
L
L
P
M
A
F
A
L
T
R
E
S
A
K
R
Y
L
G
M
R
H
F
D
V
Q
L
I
G
G
A
V
L
H
E
G
K
I
A
E
M
K
T
G
E
G
K
T
L
V
A
T
L
A
V
A
L
N
A
L
T
G
K
G
V
H
V
V
T
V
N
D
Y
L
A
R
R
D
A
E
W
M
G
P
V
Y
R
G
L
G
L
S
V
G
V
I
Q
H
-----------------------
A
-
S
T
P
A
--------------------------
E
R
R
K
A
Y
L
A
D
V
T
Y
V
T
N
S
E
L
G
F
D
Y
L
R
D
N
M
A
I
S
P
D
Q
L
V
LRH
D
H
---
P
L
H
Y
A
I
I
D
E
V
D
S
I
L
I
D
E
A
R
T
P
L
I
I
S
G
P
A
E
K
A
T
D
L
Y
Y
K
M
A
E
I
-----------
A
K
K
L
E
R
G
L
P
A
EPGVRK
E
P
------------
T
G
D
Y
T
V
E
E
K
N
R
S
V
H
L
T
L
Q
G
I
A
K
A
E
K
L
L
---
G
I
----
E
G
L
F
S
P
E
N
M
E
L
A
H
M
L
I
Q
A
I
R
A
K
E
L
Y
H
R
D
R
D
Y
I
V
Q
D
G
Q
V
I
I
V
D
E
F
T
G
R
L
M
P
G
R
R
Y
G
E
G
L
H
Q
A
I
----------
E
A
K
E
G
V
R
I
E
R
E
N
Q
T
L
A
T
I
T
Y
Q
N
F
F
R
L
Y
E
K
R
A
G
M
T
G
T
A
K
T
E
E
K
E
F
Q
E
I
Y
G
M
D
V
V
V
V
P
T
N
R
P
V
I
R
K
D
F
P
D
V
V
Y
R
T
E
K
G
K
F
Y
A
V
V
E
E
I
A
E
K
Y
E
R
G
Q
P
V
L
V
G
T
I
S
I
E
K
S
E
R
L
S
Q
M
L
K
E
PRLY
L
P
R
L
E
M
R
L
E
L
F
K
K
A
S
QKQQG
P
E
W
E
R
L
R
KLLERPAQLKDEDLAPFEGLIPPKG
N
L
R
T
A
W
E
G
L
K
R
A
V
H
T
L
A
V
L
R
----------------------------------------------------------------------------
Q
G
I
P
H
Q
V
L
N
A
K
H
H
A
R
E
A
E
I
V
A
Q
A
G
R
S
K
T
V
T
I
A
T
N
M
A
G
R
G
T
D
I
K
-------
L
GGN
P
E
Y
L
A
A
A
L
L
E
K
EGFDRYEWK
V
E
L
F
I
K
K
M
V
A
GK
E
E
E
A
R
A
L
A
Q
E
L
GIR
E
E
L
L
E
R
I
R
E
I
R
E
E
C
K
Q
D
E
-----------------------------
E
------------------------------------------------------------------
R
V
R
-----------------------------------------
A
L
G
G
L
F
I
I
G
T
E
R
H
E
S
R
R
I
D
N
Q
L
R
G
R
A
G
R
Q
G
D
P
G
G
S
R
F
Y
V
S
F
D
D
D
L
M
R
L
F
A
S
D
R
V
I
A
M
L
D
R
M
G
F
D
D
S
E
P
I
E
H
P
M
V
T
R
S
I
E
R
A
Q
K
R
V
E
D
R
N
F
A
I
R
K
Q
L
L
Q
F
D
D
V
L
S
R
Q
R
E
V
I
Y
----------
A
Q
R
R
L
-
I
L
L
GK
D
E
E
V
K
E
A
-
A
-
I
G
M
-
V
--
E
E
T
-
V
A
S
L
----
A
E
N
F
L
N
P
E
V
----
H
P
-
E
D
W
D
L
E
G
-
L
-
K
A
T
---
L
L
D
T
A
P
Q
L
Q
D
--
F
P
F
A
E
L
--
R
A
L
------
K
A
E
E
A
-------
V
E
--
R
L
V
E
A
--
A
L
K
A
-
Y
E
A
R
E
A
E
----
L
S
P
P
L
M
R
A
-
V
E
R
F
V
I
L
N
V
V
D
N
A
W
K
E
H
L
H
N
L
D
V
L
R
Q
G
I
F
L
R
G
Y
G
Q
K
D
P
F
Q
E
Y
K
I
E
A
T
R
L
F
N
E
M
V
A
F
I
K
S
E
V
A
K
F
L
F
R
L
K
V
E
-----------------------------------------------------------------------------
30
HHSearch
84.87
51%
-49
- C3 -
2IPC
-
SECA_THET8
A:
[2-939]
--
L
G
L
L
R
R
L
F
-
D
N
N
E
R
E
I
A
R
Y
Y
K
Q
V
V
E
P
V
N
R
L
E
A
E
V
E
K
L
P
D
--
L
A
A
A
Y
R
E
L
K
E
K
H
E
K
G
------
A
S
L
D
E
L
L
P
M
A
F
A
L
T
R
E
S
A
K
R
Y
L
G
M
R
H
F
D
V
Q
L
I
G
G
A
V
L
H
E
G
K
I
A
E
M
K
T
G
E
G
K
T
L
V
A
T
L
A
V
A
L
N
A
L
T
G
K
G
V
H
V
V
T
V
N
D
Y
L
A
R
R
D
A
E
W
M
G
P
V
Y
R
G
L
G
L
S
V
G
V
I
Q
H
-----------------------
A
S
T
-
P
A
--------------------------
E
R
R
K
A
Y
L
A
D
V
T
Y
V
T
N
S
E
L
G
F
D
Y
L
R
D
N
M
A
I
S
P
D
Q
L
V
---
L
R
HDH
P
L
H
Y
A
I
I
D
E
V
D
S
I
L
I
D
E
A
R
T
P
L
I
I
S
G
P
A
E
K
A
T
D
L
Y
Y
K
M
A
E
I
-----------
A
K
K
L
------------
E
R
G
L
P
A
EPGVRKEP
T
G
D
Y
T
V
E
E
K
N
R
S
V
H
L
T
L
Q
G
I
A
K
A
E
K
L
L
---
G
I
----
E
G
L
F
S
P
E
N
M
E
L
A
H
M
L
I
Q
A
I
R
A
K
E
L
Y
H
R
D
R
D
Y
I
V
Q
D
G
Q
V
I
I
V
D
E
F
T
G
R
L
M
P
G
R
R
Y
G
E
G
L
H
Q
A
I
----------
E
A
K
E
G
V
R
I
E
R
E
N
Q
T
L
A
T
I
T
Y
Q
N
F
F
R
L
Y
E
K
R
A
G
M
T
G
T
A
K
T
E
E
K
E
F
Q
E
I
Y
G
M
D
V
V
V
V
P
T
N
R
P
V
I
R
K
D
F
P
D
V
V
Y
R
T
E
K
G
K
F
Y
A
V
V
E
E
I
A
E
K
Y
E
R
G
Q
P
V
L
V
G
T
I
S
I
E
K
S
E
R
L
S
Q
M
L
K
----------------------------------------------------------------------------
E
PRLY
L
P
R
L
E
M
R
L
E
L
F
K
K
A
S
QKQQG
P
E
W
E
R
L
R
KLLERPAQLKDEDLAPFEGLIPPKG
N
L
R
T
A
W
E
G
L
K
R
A
V
H
T
L
A
V
L
R
Q
G
I
P
H
Q
V
L
N
A
K
H
H
A
R
E
A
E
I
V
A
Q
A
G
R
S
K
T
V
T
I
A
T
N
M
A
G
R
G
T
D
I
K
-------
L
------------------------------------------------------------------
G
-----------------------------
G
N
P
E
Y
L
A
A
A
L
L
E
K
EGFDRYEWK
V
E
L
F
I
K
K
M
V
A
GK
E
E
E
A
R
A
L
A
Q
E
L
GIR
E
E
L
L
E
R
I
R
E
I
R
E
E
C
K
Q
D
E
E
R
V
R
-----------------------------------------
A
L
G
G
L
F
I
I
G
T
E
R
H
E
S
R
R
I
D
N
Q
L
R
G
R
A
G
R
Q
G
D
P
G
G
S
R
F
Y
V
S
F
D
D
D
L
M
R
L
F
A
S
D
R
V
I
A
M
L
D
R
M
G
F
D
D
S
E
P
I
E
H
P
M
V
T
R
S
I
E
R
A
Q
K
R
V
E
D
R
N
F
A
I
R
K
Q
L
L
Q
F
D
D
V
L
S
R
Q
R
E
V
I
Y
----------
A
Q
R
R
L
-
I
L
-----
L
G
K
D
E
-
E
V
K
E
A
-
A
--
I
G
M
-
V
E
E
T
----
V
A
S
L
A
E
N
F
L
----
N
P
--
E
V
H
P
E
D
-
W
-
D
L
E
---
G
L
K
A
T
L
L
D
T
A
--
P
Q
L
Q
D
F
P
F
A
E
L
RA----
L
K
A
E
E
-------
A
V
--
E
R
L
V
E
--
A
A
L
K
A
Y
E
A
R
E
A
E
----
L
S
P
P
L
M
R
A
-
V
E
R
F
V
I
L
N
V
V
D
N
A
W
K
E
H
L
H
N
L
D
V
L
R
Q
G
I
F
L
R
G
Y
G
Q
K
D
P
F
Q
E
Y
K
I
E
A
T
R
L
F
N
E
M
V
A
F
I
K
S
E
V
A
K
F
L
F
R
L
K
V
E
-----------------------------------------------------------------------------
19
PsiBlast_PDB
84.52
46%
-59
- C3 -
1NL3
-
SECA1_MYCTU
A:
[1-827]
----
I
L
S
K
L
L
R
L
G
E
G
R
M
V
K
-
R
L
K
K
V
A
D
Y
V
G
T
L
S
D
D
V
E
K
L
T
D
A
E
L
R
A
K
T
D
E
F
K
R
R
L
A
D
Q
K
---
N
P
E
T
L
D
D
L
L
P
E
A
F
A
V
A
R
E
A
A
W
R
V
L
D
Q
R
P
F
D
V
Q
V
M
G
A
A
A
L
H
L
G
N
V
A
E
M
K
T
G
E
G
K
T
L
T
C
V
L
P
A
Y
L
N
A
L
A
G
N
G
V
H
I
V
T
V
N
D
Y
L
A
K
R
D
S
E
W
M
G
R
V
H
R
F
L
G
L
Q
V
G
V
I
L
A
-----------------------
T
M
T
P
D
E
--------------------------
R
R
V
-
A
Y
N
A
D
I
T
Y
G
T
N
N
E
F
G
F
D
Y
L
R
D
N
M
A
H
S
L
D
D
L
V
---
Q
R
---
G
H
H
Y
A
I
V
D
E
V
D
S
I
L
I
D
E
A
R
T
P
L
I
I
S
G
P
A
D
G
A
S
N
W
Y
T
E
F
A
R
L
-----------
A
P
L
M
------------
E
K
------------
D
V
H
Y
E
V
D
L
R
K
R
T
V
G
V
H
E
K
G
V
E
F
V
E
D
Q
L
---
G
I
----
D
N
L
Y
E
A
A
N
S
P
L
V
S
Y
L
N
N
A
L
K
A
K
E
L
F
S
R
D
K
D
Y
I
V
R
D
G
E
V
L
I
V
D
E
F
T
G
R
V
L
I
G
R
R
Y
N
E
G
M
H
Q
A
I
----------
E
A
K
E
H
V
E
I
K
A
E
N
Q
T
L
A
T
I
T
L
Q
N
Y
F
R
L
Y
D
K
L
A
G
M
T
G
T
A
Q
T
E
A
A
E
L
H
E
I
Y
K
L
G
V
V
S
I
P
T
N
M
P
M
I
R
E
D
Q
S
D
L
I
Y
K
T
E
E
A
K
Y
I
A
V
V
D
D
V
A
E
R
Y
A
K
G
Q
P
V
L
I
G
T
T
S
V
E
R
S
E
Y
L
S
R
Q
F
T
----------------------------------------------------------------------------
K
----------------------------------------------------------------------------
R
R
I
P
H
N
V
L
N
A
K
Y
H
E
Q
E
A
T
I
I
A
V
A
G
R
R
G
G
V
T
V
A
T
N
M
A
G
R
G
T
D
I
V
LGGN
V
D
F
L
------------------------------------------------------------------
T
-----------------------------
D
Q
R
L
R
E
R
GLDPVET
P
E
E
Y
E
A
A
W
H
S
E
L
P
I
V
K
E
E
A
S
K
E
A
K
-----------------------------
E
V
I
-----------------------------------------
E
A
G
G
L
Y
V
L
G
T
E
R
H
E
S
R
R
I
D
N
Q
L
R
G
R
S
G
R
Q
G
D
P
G
E
S
R
F
Y
L
S
L
G
D
E
L
M
R
R
F
N
G
A
A
L
E
T
L
L
T
R
L
N
L
P
D
D
V
P
I
E
A
K
M
V
T
R
A
I
K
S
A
Q
T
Q
V
E
Q
Q
N
F
E
V
R
K
N
V
L
K
Y
D
E
V
M
N
Q
Q
R
K
V
I
Y
A
E
R
R
R
I
L
E
GE
N
L
K
D
Q
-
A
L
-----
D
M
V
R
D
V
I
-
T
A
Y
-
V
D
G
A
T
G
-
E
G
Y
A
EDWD
L
D
A
L
W
T
A
L
K
----
T
L
-
Y
P
V
G
I
T
A
-
D
-
S
L
---------
T
------------------------
R
E
E
L
-------
L
E
--
A
L
L
K
D
A
E
R
A
Y
A
A
R
E
A
E
L
E
E
----
I
A
G
E
G
A
M
R
Q
L
E
R
N
V
L
L
N
V
I
D
R
K
W
R
E
H
L
Y
E
M
D
Y
L
K
E
G
I
G
L
R
A
M
A
Q
R
D
P
L
V
E
Y
Q
R
E
G
Y
D
M
F
M
A
M
L
D
G
M
K
E
E
S
V
G
F
L
F
N
V
T
V
------------------------------------------------------------------------------
8
PsiBlast_PDB
84.38
48%
-65
- C3 -
2FSG
1
SECA_ECOLI
A:
[8-826]
---------------
R
T
L
R
-
R
M
R
K
V
V
N
I
I
N
A
M
E
P
E
M
E
K
L
S
D
E
E
L
K
G
K
T
A
E
F
R
A
R
L
E
K
G
E
------
V
L
E
N
L
I
P
E
A
F
A
V
V
R
E
A
S
K
R
V
F
G
M
R
H
F
D
V
Q
L
L
G
G
M
V
L
N
E
R
C
I
A
E
M
R
T
G
E
G
K
T
L
T
A
T
L
P
A
Y
L
N
A
L
T
G
K
G
V
H
V
V
T
V
N
D
Y
L
A
Q
R
D
A
E
N
N
R
P
L
F
E
F
L
G
L
T
V
G
-
I
N
L
-----------------------
P
G
M
P
A
P
--------------------------
A
K
R
E
A
Y
A
A
D
I
T
Y
G
T
N
N
E
Y
G
F
D
Y
L
R
D
N
M
A
F
S
P
E
E
R
V
---
Q
R
---
K
L
H
Y
A
L
V
D
E
V
D
S
I
L
I
D
E
A
R
T
P
L
I
I
S
G
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Q
T
L
A
S
I
T
F
Q
N
Y
F
R
L
Y
E
K
L
A
G
M
T
G
T
A
D
T
E
A
F
E
F
S
S
I
Y
K
L
D
T
V
V
V
P
T
N
R
P
M
I
R
K
D
L
P
D
L
V
Y
M
T
E
A
E
K
I
Q
A
I
I
E
D
I
K
E
R
T
A
K
G
Q
P
V
L
V
G
T
I
S
I
E
K
S
E
L
V
S
N
E
L
T
----------------------------------------------------------------------------
K
----------------------------------------------------------------------------
A
G
I
K
H
N
V
L
N
A
K
F
H
A
N
E
A
A
I
V
A
Q
A
G
Y
P
A
A
V
T
I
A
T
N
M
A
G
R
G
T
D
I
V
-------
L
------------------------------------------------------------------
G
GS
W
Q
A
E
V
A
A
LENPTAEQ
I
E
K
I
K
A
D
W
Q
V
R
H
D
------------------------------------------------------------------
A
V
L
-----------------------------------------
E
A
G
G
L
H
I
I
G
T
E
R
H
E
S
R
R
I
D
N
Q
L
R
G
R
S
G
R
Q
G
D
A
G
S
S
R
F
Y
L
S
M
E
D
A
L
M
R
I
F
A
S
D
R
V
S
G
M
M
R
K
L
G
M
K
P
G
E
A
I
E
H
P
W
V
T
K
A
I
A
N
A
Q
R
K
V
E
S
R
N
F
D
I
R
K
Q
L
L
E
Y
D
D
V
A
N
D
Q
R
R
A
I
Y
----------
S
Q
R
N
E
-
L
L
-----
D
V
S
-
D
-
V
-
S
E
T
-
I
--
N
S
I
-
R
E
D
V
----
F
K
A
T
I
D
A
Y
------
I
-
P
P
Q
S
L
E
E
-
M
W
D
I
P
---
G
L
Q
E
R
L
K
N
D
F
--
D
L
D
L
P
I
--
A
E
W
------
L
D
K
E
P
ELH
E
E
T
L
R
E
--
R
I
L
A
Q
--
S
I
E
V
-
Y
Q
R
K
E
E
V
----
V
G
A
E
M
M
R
H
-
F
E
K
G
V
M
L
Q
T
L
D
S
L
W
K
E
H
L
A
A
M
D
Y
L
R
Q
G
I
H
L
R
G
Y
A
Q
K
D
P
K
Q
E
Y
K
R
E
S
F
S
M
F
A
A
M
L
E
S
L
K
Y
E
V
I
S
T
L
S
K
V
Q
V
R
M
P
---------------------------------------------------------------------------
24
PsiBlast_CBE
84.30
46%
-59
- C3 -
1NKT
2
SECA1_MYCTU
B:
[31-857]
----
I
L
S
K
L
L
R
L
G
E
G
R
M
V
K
-
R
L
K
K
V
A
D
Y
V
G
T
L
S
D
D
V
E
K
L
T
D
A
E
L
R
A
K
T
D
E
F
K
R
R
L
A
D
Q
K
---
N
P
E
T
L
D
D
L
L
P
E
A
F
A
V
A
R
E
A
A
W
R
V
L
D
Q
R
P
F
D
V
Q
V
M
G
A
A
A
L
H
L
G
N
V
A
E
M
K
T
G
E
G
K
T
L
T
C
V
L
P
A
Y
L
N
A
L
A
G
N
G
V
H
I
V
T
V
N
D
Y
L
A
K
R
D
S
E
W
M
G
R
V
H
R
F
L
G
L
Q
V
G
V
I
L
A
-----------------------
T
M
T
P
D
E
--------------------------
R
R
V
-
A
Y
N
A
D
I
T
Y
G
T
N
N
E
F
G
F
D
Y
L
R
D
N
M
A
H
S
L
D
D
L
V
---
Q
R
---
G
H
H
Y
A
I
V
D
E
V
D
S
I
L
I
D
E
A
R
T
P
L
I
I
S
G
P
A
D
G
A
S
N
W
Y
T
E
F
A
R
L
-----------
A
P
L
M
------------
E
K
------------
D
V
H
Y
E
V
D
L
R
K
R
T
V
G
V
H
E
K
G
V
E
F
V
E
D
Q
L
---
G
I
----
D
N
L
Y
E
A
A
N
S
P
L
V
S
Y
L
N
N
A
L
K
A
K
E
L
F
S
R
D
K
D
Y
I
V
R
D
G
E
V
L
I
V
D
E
F
T
G
R
V
L
I
G
R
R
Y
N
E
G
M
H
Q
A
I
----------
E
A
K
E
H
V
E
I
K
A
E
N
Q
T
L
A
T
I
T
L
Q
N
Y
F
R
L
Y
D
K
L
A
G
M
T
G
T
A
Q
T
E
A
A
E
L
H
E
I
Y
K
L
G
V
V
S
I
P
T
N
M
P
M
I
R
E
D
Q
S
D
L
I
Y
K
T
E
E
A
K
Y
I
A
V
V
D
D
V
A
E
R
Y
A
K
G
Q
P
V
L
I
G
T
T
S
V
E
R
S
E
Y
L
S
R
Q
F
T
----------------------------------------------------------------------------
K
----------------------------------------------------------------------------
R
R
I
P
H
N
V
L
N
A
K
Y
H
E
Q
E
A
T
I
I
A
V
A
G
R
R
G
G
V
T
V
A
T
N
M
A
G
R
G
T
D
I
V
LGGNVDF
L
------------------------------------------------------------------
T
-----------------------------
D
QRLRERGLDPVETPEEYEAAWHSELPIVKEEASKEAK-----------------------------
E
V
I
-----------------------------------------
E
A
G
G
L
Y
V
L
G
T
E
R
H
E
S
R
R
I
D
N
Q
L
R
G
R
S
G
R
Q
G
D
P
G
E
S
R
F
Y
L
S
L
G
D
E
L
M
R
R
F
N
G
A
A
L
E
T
L
L
T
R
L
N
L
P
D
D
V
P
I
E
A
K
M
V
T
R
A
I
K
S
A
Q
T
Q
V
E
Q
Q
N
F
E
V
R
K
N
V
L
K
Y
D
E
V
M
N
Q
Q
R
K
V
I
Y
AERRRILEGE
N
L
K
D
Q
-
A
L
-----
D
M
V
R
D
V
I
-
T
A
Y
-
V
DG
A
T
G
-
E
G
Y
A
EDWD
L
D
A
L
W
T
A
L
K
----
T
L
-
Y
P
V
G
I
T
A
-
D
-
S
L
---------
T
---------------------------
L
-------
L
E
--
A
L
L
K
D
AE
R
A
Y
A
A
R
E
A
E
L
E
E
----
I
A
G
E
G
A
M
R
Q
L
E
R
N
V
L
L
N
V
I
D
R
K
W
R
E
H
L
Y
E
M
D
Y
L
K
E
G
I
G
L
R
A
M
A
Q
R
D
P
L
V
E
Y
Q
R
E
G
Y
D
M
F
M
A
M
L
D
G
M
K
E
E
S
V
G
F
L
F
N
V
T
V
------------------------------------------------------------------------------
4
PsiBlast_PDB
84.29
50%
-54
- C3 -
2VDA
-
SECA_ECOLI
A:
[9-830]
--------
V
F
G
S
R
N
D
R
T
L
R
-
R
M
R
K
V
V
N
I
I
N
A
M
E
P
E
M
E
K
L
S
D
E
E
L
K
G
K
T
A
E
F
R
A
R
L
E
K
G
E
------
V
L
E
N
L
I
P
E
A
F
A
V
V
R
E
A
S
K
R
V
F
G
M
R
H
F
D
V
Q
L
L
G
G
M
V
L
N
E
R
C
I
A
E
M
R
T
G
E
G
K
T
L
T
A
T
L
P
A
Y
L
N
A
L
T
G
K
G
V
H
V
V
T
V
N
D
Y
L
A
Q
R
D
A
E
N
N
R
P
L
F
E
F
L
G
L
T
V
G
I
N
L
P
-----------------------
G
M
P
A
P
A
--------------------------
K
R
-
E
A
Y
A
A
D
I
T
Y
G
T
N
N
E
Y
G
F
D
Y
L
R
D
N
M
A
F
S
P
E
E
R
V
---
Q
R
---
K
L
H
Y
A
L
V
D
E
V
D
S
I
L
I
D
E
A
R
T
P
L
I
I
S
G
P
A
E
D
S
S
E
M
Y
K
R
V
N
K
I
I
P
H
L
IRQEKED
S
E
T
F
------------
Q
G
------------
E
G
H
F
S
V
D
E
K
S
R
Q
V
N
L
T
E
R
G
L
V
L
I
E
E
L
L
VKE
G
I
MDEG
E
S
L
Y
S
P
A
N
I
M
L
M
H
H
V
T
A
A
L
R
A
H
A
L
F
T
R
D
V
D
Y
I
V
K
D
G
E
V
I
I
V
D
E
H
T
G
R
T
M
Q
G
R
R
W
S
D
G
L
H
Q
A
V
----------
E
A
K
E
G
V
Q
I
Q
N
E
N
Q
T
L
A
S
I
T
F
Q
N
Y
F
R
L
Y
E
K
L
A
G
M
T
G
T
A
D
T
E
A
F
E
F
S
S
I
Y
K
L
D
T
V
V
V
P
T
N
R
P
M
I
R
K
D
L
P
D
L
V
Y
M
T
E
A
E
K
I
Q
A
I
I
E
D
I
K
E
R
T
A
K
G
Q
P
V
L
V
G
T
I
S
I
E
K
S
E
L
V
S
N
E
L
T
----------------------------------------------------------------------------
K
----------------------------------------------------------------------------
A
G
I
K
H
N
V
L
N
A
K
F
H
A
N
E
A
A
I
V
A
Q
A
G
Y
P
A
A
V
T
I
A
T
N
M
A
G
R
G
T
D
I
V
-------
L
------------------------------------------------------------------
G
GS
W
Q
A
E
V
A
A
LENPT
A
E
Q
I
E
K
I
K
A
D
W
Q
V
R
H
D
------------------------------------------------------------------
A
V
L
-----------------------------------------
E
A
G
G
L
H
I
I
G
T
E
R
H
E
S
R
R
I
D
N
Q
L
R
G
R
S
G
R
Q
G
D
A
G
S
S
R
F
Y
L
S
M
E
D
A
L
M
R
I
F
A
S
D
R
V
S
G
M
M
R
K
L
G
M
K
P
G
E
A
I
E
H
P
W
V
T
K
A
I
A
N
A
Q
R
K
V
E
S
R
N
F
D
I
R
K
Q
L
L
E
Y
D
D
V
A
N
D
Q
R
R
A
I
Y
----------
S
Q
R
N
E
-
L
L
-----
D
V
S
-
D
-
V
-
S
E
T
-
I
--
N
S
I
-
R
E
D
V
----
F
K
A
T
I
D
A
Y
------
I
-
P
P
Q
S
L
E
E
M
W
-
D
I
P
---
G
L
Q
E
R
L
K
N
D
F
--
D
L
D
L
P
I
--
A
E
W
------
L
D
K
E
P
ELHE
E
T
L
R
E
--
R
I
L
A
Q
--
S
I
E
V
-
Y
Q
R
K
E
E
V
----
V
G
A
E
M
M
R
H
-
F
E
K
G
V
M
L
Q
T
L
D
S
L
W
K
E
H
L
A
A
M
D
Y
L
R
Q
G
I
H
L
R
G
Y
A
Q
K
D
P
K
Q
E
Y
K
R
E
S
F
S
M
F
A
A
M
L
E
S
L
K
Y
E
V
I
S
T
L
S
K
V
Q
V
R
M
P
E
E
-------------------------------------------------------------------------
18
PsiBlast_PDB
84.01
46%
-59
- C3 -
1NKT
2
SECA1_MYCTU
A:
[31-857]
----
I
L
S
K
L
L
R
L
G
E
G
R
M
V
K
-
R
L
K
K
V
A
D
Y
V
G
T
L
S
D
D
V
E
K
L
T
D
A
E
L
R
A
K
T
D
E
F
K
R
R
L
A
D
Q
K
---
N
P
E
T
L
D
D
L
L
P
E
A
F
A
V
A
R
E
A
A
W
R
V
L
D
Q
R
P
F
D
V
Q
V
M
G
A
A
A
L
H
L
G
N
V
A
E
M
K
T
G
E
G
K
T
L
T
C
V
L
P
A
Y
L
N
A
L
A
G
N
G
V
H
I
V
T
V
N
D
Y
L
A
K
R
D
S
E
W
M
G
R
V
H
R
F
L
G
L
Q
V
G
V
I
L
A
-----------------------
T
M
T
P
D
E
--------------------------
R
R
V
-
A
Y
N
A
D
I
T
Y
G
T
N
N
E
F
G
F
D
Y
L
R
D
N
M
A
H
S
L
D
D
L
V
---
Q
R
---
G
H
H
Y
A
I
V
D
E
V
D
S
I
L
I
D
E
A
R
T
P
L
I
I
S
G
P
A
D
G
A
S
N
W
Y
T
E
F
A
R
L
-----------
A
P
L
M
------------
E
K
------------
D
V
H
Y
E
V
D
L
R
K
R
T
V
G
V
H
E
K
G
V
E
F
V
E
D
Q
L
---
G
I
----
D
N
L
Y
E
A
A
N
S
P
L
V
S
Y
L
N
N
A
L
K
A
K
E
L
F
S
R
D
K
D
Y
I
V
R
D
G
E
V
L
I
V
D
E
F
T
G
R
V
L
I
G
R
R
Y
N
E
G
M
H
Q
A
I
----------
E
A
K
E
H
V
E
I
K
A
E
N
Q
T
L
A
T
I
T
L
Q
N
Y
F
R
L
Y
D
K
L
A
G
M
T
G
T
A
Q
T
E
A
A
E
L
H
E
I
Y
K
L
G
V
V
S
I
P
T
N
M
P
M
I
R
E
D
Q
S
D
L
I
Y
K
T
E
E
A
K
Y
I
A
V
V
D
D
V
A
E
R
Y
A
K
G
Q
P
V
L
I
G
T
T
S
V
E
R
S
E
Y
L
S
R
Q
F
T
----------------------------------------------------------------------------
K
----------------------------------------------------------------------------
R
R
I
P
H
N
V
L
N
A
K
Y
H
E
Q
E
A
T
I
I
A
V
A
G
R
R
G
G
V
T
V
A
T
N
M
A
G
R
G
T
D
I
V
LGGN
V
D
F
L
------------------------------------------------------------------
T
-----------------------------
D
Q
R
L
R
E
R
GLDPVET
P
E
E
Y
E
A
A
W
H
S
E
L
P
I
V
K
E
E
A
S
K
E
A
K
-----------------------------
E
V
I
-----------------------------------------
E
A
G
G
L
Y
V
L
G
T
E
R
H
E
S
R
R
I
D
N
Q
L
R
G
R
S
G
R
Q
G
D
P
G
E
S
R
F
Y
L
S
L
G
D
E
L
M
R
R
F
N
G
A
A
L
E
T
L
L
T
R
L
N
L
P
D
D
V
P
I
E
A
K
M
V
T
R
A
I
K
S
A
Q
T
Q
V
E
Q
Q
N
F
E
V
R
K
N
V
L
K
Y
D
E
V
M
N
Q
Q
R
K
V
I
Y
A
E
R
R
R
I
L
E
GE
N
L
K
D
Q
-
A
L
-----
D
M
V
R
D
V
I
-
T
A
Y
-
V
D
G
A
T
G
-
E
G
Y
A
EDWD
L
D
A
L
W
T
A
L
K
----
T
L
-
Y
P
V
G
I
T
A
-
D
-
S
L
---------
T
---------------------------
L
-------
L
E
--
A
L
L
K
D
A
E
R
A
Y
A
A
R
E
A
E
L
E
E
----
I
A
G
E
G
A
M
R
Q
L
E
R
N
V
L
L
N
V
I
D
R
K
W
R
E
H
L
Y
E
M
D
Y
L
K
E
G
I
G
L
R
A
M
A
Q
R
D
P
L
V
E
Y
Q
R
E
G
Y
D
M
F
M
A
M
L
D
G
M
K
E
E
S
V
G
F
L
F
N
V
T
V
------------------------------------------------------------------------------
17
PsiBlast_PDB
84.00
49%
-57
- C3 -
4YS0
2
SECA_THEMA
A:
[2-802]
--------
I
L
F
D
K
N
K
R
I
L
K
-
K
Y
A
K
M
V
S
K
I
N
Q
I
E
S
D
L
R
S
K
K
N
S
E
L
I
R
L
S
M
V
L
K
E
K
V
N
S
F
E
-
D
A
D
E
H
-----
L
F
E
A
F
A
L
V
R
E
A
A
R
R
T
L
G
M
R
P
F
D
V
Q
V
M
G
G
I
A
L
H
E
G
K
V
A
E
M
K
T
G
E
G
K
T
L
A
A
T
M
P
I
Y
L
N
A
L
I
G
K
G
V
H
L
V
T
V
N
D
Y
L
A
R
R
D
A
L
W
M
G
P
V
Y
L
F
L
G
L
R
V
G
V
I
N
S
LG
K
S
Y
E
V
V
W
KN
P
D
L
A
R
K
A
I
E
E
NW
S
V
W
P
D
G
FNGEVLKEESMN
K
E
A
V
E
A
F
Q
V
E
L
K
E
I
T
R
K
E
A
Y
L
C
D
V
T
Y
G
T
N
N
E
F
G
F
D
Y
L
R
D
N
L
V
L
D
Y
N
D
K
V
---
Q
R
---
G
H
F
Y
A
I
V
D
E
A
D
S
V
L
I
D
E
A
R
T
P
L
I
I
S
G
P
S
K
E
S
P
S
V
Y
R
R
F
A
Q
I
-----------
A
K
K
F
------------
V
K
------------
D
K
D
F
T
V
D
E
K
A
R
T
I
I
L
T
E
E
G
V
A
K
A
E
K
I
I
---
G
V
----
E
N
L
Y
D
P
G
N
V
S
L
L
Y
H
L
I
N
A
L
K
A
L
H
L
F
K
K
D
V
D
Y
V
V
M
N
G
E
V
I
I
V
D
E
F
T
G
R
L
L
P
G
R
R
Y
S
G
G
L
H
Q
A
I
----------
E
A
K
E
G
V
P
I
K
E
E
S
I
T
Y
A
T
I
T
F
Q
N
Y
F
R
M
Y
E
K
L
A
G
M
T
G
T
A
K
T
E
E
S
E
F
V
Q
V
Y
G
M
E
V
V
V
I
P
T
H
K
P
M
I
R
K
D
H
D
D
L
V
F
R
T
Q
K
E
K
Y
E
K
I
V
E
E
I
E
K
R
Y
K
K
G
Q
P
V
L
V
G
T
T
S
I
E
K
S
E
L
L
S
S
M
L
K
----------------------------------------------------------------------------
K
----------------------------------------------------------------------------
K
G
I
P
H
Q
V
L
N
A
K
Y
H
E
K
E
A
E
I
V
A
K
A
G
Q
K
G
M
V
T
I
A
T
N
M
A
G
R
G
T
D
I
K
-------
L
------------------------------------------------------------------
G
-----------------------------
P
------------------------------------------------------------------
G
V
A
-----------------------------------------
E
L
G
G
L
C
I
I
G
T
E
R
H
E
S
R
R
I
D
N
Q
L
R
G
R
A
G
R
Q
G
D
P
G
E
S
I
F
F
L
S
L
E
D
D
L
L
R
I
F
G
S
E
Q
I
G
K
V
M
N
I
L
K
I
E
E
G
Q
P
I
Q
H
P
M
L
S
K
L
I
E
N
I
Q
K
K
V
E
G
I
N
F
S
I
R
K
T
L
M
E
M
D
D
V
L
D
K
Q
R
R
A
V
Y
----------
S
L
R
D
Q
I
L
L
-----
E
K
D
Y
D
-
E
-
Y
L
K
D
I
--
F
E
D
-
V
V
S
T
----
R
V
E
E
F
C
S
G
K
----
N
W
-
D
I
E
S
L
K
N
-
S
-
L
S
F
FPA
G
L
F
D
L
D
E
K
Q
F
--
S
S
S
E
E
L
--
H
D
------------------------
Y
L
F
N
--
R
L
W
E
E
Y
Q
R
K
K
Q
E
----
I
G
E
D
Y
R
K
V
-
I
-
R
F
L
M
L
R
I
I
D
D
H
W
R
R
Y
L
E
E
V
E
H
V
K
E
A
V
Q
L
R
S
----
D
P
I
V
E
F
K
K
E
T
Y
Y
M
F
D
E
M
M
R
R
I
N
D
T
I
A
N
Y
V
L
R
V
L
E
H
-----------------------------------------------------------------------------
15
PsiBlast_PDB
83.75
49%
-51
- C3 -
3JUX
2
SECA_THEMA
A:
[4-802]
----------
F
D
K
N
K
R
I
L
K
-
K
Y
A
K
M
V
S
K
I
N
Q
I
E
S
D
L
R
S
K
K
N
S
E
L
I
R
L
S
M
V
L
K
E
K
V
N
S
F
E
-
D
A
D
E
H
-----
L
F
E
A
F
A
L
V
R
E
A
A
R
R
T
L
G
M
R
P
F
D
V
Q
V
M
G
G
I
A
L
H
E
G
K
V
A
E
M
K
T
G
E
G
K
T
L
A
A
T
M
P
I
Y
L
N
A
L
I
G
K
G
V
H
L
V
T
V
N
D
Y
L
A
R
R
D
A
L
W
M
G
P
V
Y
L
F
L
G
L
R
V
G
V
I
N
S
LG
K
S
Y
E
V
V
WKN
P
D
L
A
R
K
A
I
E
E
NW
S
V
W
P
D
G
FNGEVLKEESMN
K
E
A
V
E
A
F
Q
V
E
L
K
E
I
T
R
K
E
A
Y
L
C
D
V
T
Y
G
T
N
N
E
F
G
F
D
Y
L
R
D
N
L
V
L
D
Y
N
D
K
V
---
Q
R
---
G
H
F
Y
A
I
V
D
E
A
D
S
V
L
I
D
E
A
R
T
P
L
I
I
S
G
P
S
K
E
S
P
S
V
Y
R
R
F
A
Q
I
-----------
A
K
K
F
------------
V
K
------------
D
K
D
F
T
V
D
E
K
A
R
T
I
I
L
T
E
E
G
V
A
K
A
E
K
I
I
---
G
V
----
E
N
L
Y
D
P
G
N
V
S
L
L
Y
H
L
I
N
A
L
K
A
L
H
L
F
K
K
D
V
D
Y
V
V
M
N
G
E
V
I
I
V
D
E
F
T
G
R
L
L
P
G
R
R
Y
S
G
G
L
H
Q
A
I
----------
E
A
K
E
G
V
P
I
K
E
E
S
I
T
Y
A
T
I
T
F
Q
N
Y
F
R
M
Y
E
K
L
A
G
M
T
G
T
A
K
T
E
E
S
E
F
V
Q
V
Y
G
M
E
V
V
V
I
P
T
H
K
P
M
I
R
K
D
H
D
D
L
V
F
R
T
Q
K
E
K
Y
E
K
I
V
E
E
I
E
K
R
Y
K
K
G
Q
P
V
L
V
G
T
T
S
I
E
K
S
E
L
L
S
S
M
L
K
----------------------------------------------------------------------------
K
----------------------------------------------------------------------------
K
G
I
P
H
Q
V
L
N
A
K
Y
H
E
K
E
A
E
I
V
A
K
A
G
Q
K
G
M
V
T
I
A
T
N
M
A
G
R
G
T
D
I
K
-------
L
------------------------------------------------------------------
G
-----------------------------
P
------------------------------------------------------------------
G
V
A
-----------------------------------------
E
L
G
G
L
C
I
I
G
T
E
R
H
E
S
R
R
I
D
N
Q
L
R
G
R
A
G
R
Q
G
D
P
G
E
S
I
F
F
L
S
L
E
D
D
L
L
R
I
F
G
S
E
Q
I
G
K
V
M
N
I
L
K
I
E
E
G
Q
P
I
Q
H
P
M
L
S
K
L
I
E
N
I
Q
K
K
V
E
G
I
N
F
S
I
R
K
T
L
M
E
M
D
D
V
L
D
K
Q
R
R
A
V
Y
----------
S
L
R
D
Q
I
L
L
-----
E
K
D
Y
D
-
E
-
Y
L
K
D
I
--
F
E
D
-
V
V
S
T
----
R
V
E
E
F
C
S
G
K
----
N
W
-
D
I
E
S
L
K
N
-
S
-
L
S
F
FPA
G
L
F
D
L
D
E
K
Q
F
--
S
S
S
E
E
L
--
H
D
------------------------
Y
L
F
N
--
R
L
W
E
E
Y
Q
R
K
K
Q
E
----
I
G
E
D
Y
R
K
V
-
I
-
R
F
L
M
L
R
I
I
D
D
H
W
R
R
Y
L
E
E
V
E
H
V
K
E
A
V
Q
L
R
S
Y
G
Q
K
D
P
I
V
E
F
K
K
E
T
Y
Y
M
F
D
E
M
M
R
R
I
N
D
T
I
A
N
Y
V
L
R
V
--------------------------------------------------------------------------------
6
PsiBlast_PDB
83.00
48%
-57
- C3 -
1TF5
-
SECA_BACSU
A:
[14-780]
---------------
R
T
L
N
-
R
Y
E
K
I
A
N
D
I
D
A
I
R
G
D
Y
E
N
L
S
D
D
A
L
K
H
K
T
I
E
F
K
E
R
L
E
------
K
G
A
T
T
D
D
L
L
V
E
A
F
A
V
V
R
E
A
S
R
R
V
T
G
M
F
P
F
K
V
Q
L
M
G
G
V
A
L
H
D
G
N
I
A
E
M
K
T
G
E
G
K
T
L
T
S
T
L
P
V
Y
L
N
A
L
T
G
K
G
V
H
V
V
T
V
N
E
Y
L
A
S
R
D
A
E
Q
M
G
K
I
F
E
F
L
G
L
T
V
G
L
N
L
N
-----------------------
S
M
S
K
D
E
--------------------------
K
R
-
E
A
Y
A
A
D
I
T
Y
S
T
N
N
E
L
G
F
D
Y
L
R
D
N
M
V
L
Y
K
E
Q
M
V
---
Q
R
---
P
L
H
F
A
V
I
D
E
V
D
S
I
L
I
D
E
A
R
T
P
L
I
I
S
G
Q
A
A
K
S
T
K
L
Y
V
Q
A
N
A
F
-----------
V
R
T
L
------------
K
A
------------
E
K
D
Y
T
Y
D
I
K
T
K
A
V
Q
L
T
E
E
G
M
T
K
A
E
K
A
F
---
G
I
----
D
N
L
F
D
V
K
H
V
A
L
N
H
H
I
N
Q
A
L
K
A
H
V
A
M
Q
K
D
V
D
Y
V
V
E
D
G
Q
V
V
I
V
D
S
F
T
G
R
L
M
K
G
R
R
Y
S
E
G
L
H
Q
A
I
----------
E
A
K
E
G
L
E
I
Q
N
E
S
M
T
L
A
T
I
T
F
Q
N
Y
F
R
M
Y
E
K
L
A
G
M
T
G
T
A
K
T
E
E
E
E
F
R
N
I
Y
N
M
Q
V
V
T
I
P
T
N
R
P
V
V
R
D
D
R
P
D
L
I
Y
R
T
M
E
G
K
F
K
A
V
A
E
D
V
A
Q
R
Y
M
T
G
Q
P
V
L
V
G
T
V
A
V
E
T
S
E
L
I
S
K
L
L
K
----------------------------------------------------------------------------
N
----------------------------------------------------------------------------
K
G
I
P
H
Q
V
L
N
A
K
N
H
E
R
E
A
Q
I
I
E
E
A
G
Q
K
G
A
V
T
I
A
T
N
M
A
G
R
G
T
D
I
K
-------
L
------------------------------------------------------------------
G
-----------------------------
E
------------------------------------------------------------------
G
V
K
-----------------------------------------
E
L
G
G
L
A
V
V
G
T
E
R
H
E
S
R
R
I
D
N
Q
L
R
G
R
S
G
R
Q
G
D
P
G
I
T
Q
F
Y
L
S
M
E
D
E
L
M
R
R
F
G
A
E
R
T
M
A
M
L
D
R
F
G
M
D
D
S
T
P
I
Q
S
K
M
V
S
R
A
V
E
S
S
Q
K
R
V
E
G
N
N
F
D
S
R
K
Q
L
L
Q
Y
D
D
V
L
R
Q
Q
R
E
V
I
Y
----------
K
Q
R
F
E
-
V
I
-----
D
--------------
S
E
N
L
R
E
I
V
----
E
N
M
I
K
S
S
L
E
R
A
I
A
A
Y
T
P
R
E
E
L
P
E
-
E
W
K
L
D
---
G
L
V
D
L
I
N
T
T
Y
LD
E
G
A
L
E
K
--
S
D
I
------
F
G
K
E
P
-------
D
E
M
L
E
L
I
M
D
--
R
I
I
T
K
Y
N
E
K
E
E
Q
----
F
G
K
E
Q
M
R
E
-
F
E
K
V
I
V
L
R
A
V
D
S
K
W
M
D
H
I
D
A
M
D
Q
L
R
Q
G
I
H
L
R
A
Y
A
Q
T
N
P
L
R
E
Y
Q
M
E
G
F
A
M
F
E
H
M
I
E
S
I
E
D
E
V
A
K
F
V
M
K
A
E
I
------------------------------------------------------------------------------
5
PsiBlast_PDB
82.19
48%
-57
- C3 -
1TF2
2
SECA_BACSU
A:
[17-783]
---------------
R
T
L
N
-
R
Y
E
K
I
A
N
D
I
D
A
I
R
G
D
Y
E
N
L
S
D
D
A
L
K
H
K
T
I
E
F
K
E
R
L
E
------
K
G
A
T
T
D
D
L
L
V
E
A
F
A
V
V
R
E
A
S
R
R
V
T
G
M
F
P
F
K
V
Q
L
M
G
G
V
A
L
H
D
G
N
I
A
E
M
K
T
G
E
G
K
T
L
T
S
T
L
P
V
Y
L
N
A
L
T
G
K
G
V
H
V
V
T
V
N
E
Y
L
A
S
R
D
A
E
Q
M
G
K
I
F
E
F
L
G
L
T
V
G
L
N
L
N
-----------------------
S
M
S
K
D
E
--------------------------
K
R
-
E
A
Y
A
A
D
I
T
Y
S
T
N
N
E
L
G
F
D
Y
L
R
D
N
M
V
L
Y
K
E
Q
M
V
---
Q
R
---
P
L
H
F
A
V
I
D
E
V
D
S
I
L
I
D
E
A
R
T
P
L
I
I
S
G
Q
A
A
K
S
T
K
L
Y
V
Q
A
N
A
F
-----------
V
R
T
L
------------
K
A
------------
E
K
D
Y
T
Y
D
I
K
T
K
A
V
Q
L
T
E
E
G
M
T
K
A
E
K
A
F
---
G
I
----
D
N
L
F
D
V
K
H
V
A
L
N
H
H
I
N
Q
A
L
K
A
H
V
A
M
Q
K
D
V
D
Y
V
V
E
D
G
Q
V
V
I
V
D
S
F
T
G
R
L
M
K
G
R
R
Y
S
E
G
L
H
Q
A
I
----------
E
A
K
E
G
L
E
I
Q
N
E
S
M
T
L
A
T
I
T
F
Q
N
Y
F
R
M
Y
E
K
L
A
G
M
T
G
T
A
K
T
E
E
E
E
F
R
N
I
Y
N
M
Q
V
V
T
I
P
T
N
R
P
V
V
R
D
D
R
P
D
L
I
Y
R
T
M
E
G
K
F
K
A
V
A
E
D
V
A
Q
R
Y
M
T
G
Q
P
V
L
V
G
T
V
A
V
E
T
S
E
L
I
S
K
L
L
K
----------------------------------------------------------------------------
N
----------------------------------------------------------------------------
K
G
I
P
H
Q
V
L
N
A
K
N
H
E
R
E
A
Q
I
I
E
E
A
G
Q
K
G
A
V
T
I
A
T
N
M
A
G
R
G
T
D
I
K
-------
L
------------------------------------------------------------------
G
-----------------------------
E
------------------------------------------------------------------
G
V
K
-----------------------------------------
E
L
G
G
L
A
V
V
G
T
E
R
H
E
S
R
R
I
D
N
Q
L
R
G
R
S
G
R
Q
G
D
P
G
I
T
Q
F
Y
L
S
M
E
D
E
L
M
R
R
F
G
A
E
R
T
M
A
M
L
D
R
F
G
M
D
D
S
T
P
I
Q
S
K
M
V
S
R
A
V
E
S
S
Q
K
R
V
E
G
N
N
F
D
S
R
K
Q
L
L
Q
Y
D
D
V
L
R
Q
Q
R
E
V
I
Y
----------
K
Q
R
F
E
-
V
I
-----
D
--------------
S
E
N
L
R
E
I
V
----
E
N
M
I
K
S
S
L
E
R
A
I
A
A
Y
T
P
R
E
---
E
-
E
W
K
L
D
---
G
L
V
D
L
I
N
T
T
Y
LD
E
G
A
L
E
K
--
S
D
I
------
F
G
K
E
P
-------
D
E
M
L
E
L
I
M
D
--
R
I
I
T
K
Y
N
E
K
E
E
Q
----
F
G
K
E
Q
M
R
E
-
F
E
K
V
I
V
L
R
A
V
D
S
K
W
M
D
H
I
D
A
M
D
Q
L
R
Q
G
I
H
L
R
A
Y
A
Q
T
N
P
L
R
E
Y
Q
M
E
G
F
A
M
F
E
H
M
I
E
S
I
E
D
E
V
A
K
F
V
M
K
A
E
I
------------------------------------------------------------------------------
13
PsiBlast_PDB
81.68
49%
-54
- C3 -
3JV2
3
SECA_BACSU
A:
[18-773]
----------------
T
L
N
-
R
Y
E
K
I
A
N
D
I
D
A
I
R
G
D
Y
E
N
L
S
D
D
A
L
K
H
K
T
I
E
F
K
E
R
L
E
------
K
G
A
T
T
D
D
L
L
V
E
A
F
A
V
V
R
E
A
S
R
R
V
T
G
M
F
P
F
K
V
Q
L
M
G
G
V
A
L
H
D
G
N
I
A
E
M
K
T
G
E
G
K
T
L
T
S
T
L
P
V
Y
L
N
A
L
T
G
K
G
V
H
V
V
T
V
N
E
Y
L
A
S
R
D
A
E
Q
M
G
K
I
F
E
F
L
G
L
T
V
G
L
N
L
N
-----------------------
S
M
S
K
D
E
--------------------------
K
R
-
E
A
Y
A
A
D
I
T
Y
S
T
N
N
E
L
G
F
D
Y
L
R
D
N
M
V
L
Y
K
E
Q
M
V
---
Q
R
---
P
L
H
F
A
V
I
D
E
V
D
S
I
L
I
D
E
A
R
T
P
L
I
I
S
G
Q
A
A
K
S
T
K
L
Y
V
Q
A
N
A
F
-----------
V
R
T
L
------------
K
A
------------
E
K
D
Y
T
Y
D
I
K
T
K
A
V
Q
L
T
E
E
G
M
T
K
A
E
K
A
F
---
G
I
----
D
N
L
F
D
V
K
H
V
A
L
N
H
H
I
N
Q
A
L
K
A
H
V
A
M
Q
K
D
V
D
Y
V
V
E
D
G
Q
V
V
I
V
D
S
F
T
G
R
L
M
K
G
R
R
Y
S
E
G
L
H
Q
A
I
----------
E
A
K
E
G
L
E
I
Q
N
E
S
M
T
L
A
T
I
T
F
Q
N
Y
F
R
M
Y
E
K
L
A
G
M
T
G
T
A
K
T
E
E
E
E
F
R
N
I
Y
N
M
Q
V
V
T
I
P
T
N
R
P
V
V
R
D
D
R
P
D
L
I
Y
R
T
M
E
G
K
F
K
A
V
A
E
D
V
A
Q
R
Y
M
T
G
Q
P
V
L
V
G
T
V
A
V
E
T
S
E
L
I
S
K
L
L
K
----------------------------------------------------------------------------
N
----------------------------------------------------------------------------
K
G
I
P
H
Q
V
L
N
A
K
N
H
E
R
E
A
Q
I
I
E
E
A
G
Q
K
G
A
V
T
I
A
T
N
M
A
G
R
G
T
D
I
K
-------
L
------------------------------------------------------------------
G
-----------------------------
E
------------------------------------------------------------------
G
V
K
-----------------------------------------
E
L
G
G
L
A
V
V
G
T
E
R
H
E
S
R
R
I
D
N
Q
L
R
G
R
S
G
R
Q
G
D
P
G
I
T
Q
F
Y
L
S
M
E
D
E
L
M
R
R
F
G
A
E
R
T
M
A
M
L
D
R
F
G
M
D
D
S
T
P
I
Q
S
K
M
V
S
R
A
V
E
S
S
Q
K
R
V
E
G
N
N
F
D
S
R
K
Q
L
L
Q
Y
D
D
V
L
R
Q
Q
R
E
V
I
Y
----------
K
Q
R
F
E
-
V
I
-----
D
--------------
S
E
N
L
R
E
I
V
----
E
N
M
I
K
S
S
L
E
R
A
I
A
A
Y
T
P
--------W
K
L
D
---
G
L
V
D
L
I
N
T
T
Y
LD
E
G
A
L
E
K
--
S
D
I
------
F
G
K
E
P
-------
D
E
M
L
E
L
I
M
D
--
R
I
I
T
K
Y
N
E
K
E
E
Q
----
F
G
K
E
Q
M
R
E
-
F
E
K
V
I
V
L
R
A
V
D
S
K
W
M
D
H
I
D
A
M
D
Q
L
R
Q
G
I
H
L
R
A
Y
A
Q
T
N
P
L
R
E
Y
Q
M
E
G
F
A
M
F
E
H
M
I
E
S
I
E
D
E
V
A
K
F
V
M
K
A
E
-------------------------------------------------------------------------------
22
PsiBlast_CBE
81.67
49%
-56
- C3 -
3JV2
3
SECA_BACSU
B:
[17-773]
---------------
R
T
L
N
-
R
Y
E
K
I
A
N
D
I
D
A
I
R
G
D
Y
E
N
L
S
D
D
A
L
K
H
K
T
I
E
F
K
E
R
L
E
------
K
G
A
T
T
D
D
L
L
V
E
A
F
A
V
V
R
E
A
S
R
R
V
T
G
M
F
P
F
K
V
Q
L
M
G
G
V
A
L
H
D
G
N
I
A
E
M
K
T
G
E
G
K
T
L
T
S
T
L
P
V
Y
L
N
A
L
T
G
K
G
V
H
V
V
T
V
N
E
Y
L
A
S
R
D
A
E
Q
M
G
K
I
F
E
F
L
G
L
T
V
G
L
N
L
N
-----------------------
S
M
S
K
D
E
--------------------------
K
R
-
E
A
Y
A
A
D
I
T
Y
S
T
N
N
E
L
G
F
D
Y
L
R
D
N
M
V
L
Y
K
E
Q
M
V
---
Q
R
---
P
L
H
F
A
V
I
D
E
V
D
S
I
L
I
D
E
A
R
T
P
L
I
I
S
G
Q
A
A
K
S
T
K
L
Y
V
Q
A
N
A
F
-----------
V
R
T
L
------------
K
A
------------
E
K
D
Y
T
Y
D
I
K
T
K
A
V
Q
L
T
E
E
G
M
T
K
A
E
K
A
F
---
G
I
----
D
N
L
F
D
V
K
H
V
A
L
N
H
H
I
N
Q
A
L
K
A
H
V
A
M
Q
K
D
V
D
Y
V
V
E
D
G
Q
V
V
I
V
D
S
F
T
G
R
L
M
K
G
R
R
Y
S
E
G
L
H
Q
A
I
----------
E
A
K
E
G
L
E
I
Q
N
E
S
M
T
L
A
T
I
T
F
Q
N
Y
F
R
M
Y
E
K
L
A
G
M
T
G
T
A
K
T
E
E
E
E
F
R
N
I
Y
N
M
Q
V
V
T
I
P
T
N
R
P
V
V
R
D
D
R
P
D
L
I
Y
R
T
M
E
G
K
F
K
A
V
A
E
D
V
A
Q
R
Y
M
T
G
Q
P
V
L
V
G
T
V
A
V
E
T
S
E
L
I
S
K
L
L
K
----------------------------------------------------------------------------
N
----------------------------------------------------------------------------
K
G
I
P
H
Q
V
L
N
A
K
N
H
E
R
E
A
Q
I
I
E
E
A
G
Q
K
G
A
V
T
I
A
T
N
M
A
G
R
G
T
D
I
K
-------
L
------------------------------------------------------------------
G
-----------------------------
E
------------------------------------------------------------------
G
V
K
-----------------------------------------
E
L
G
G
L
A
V
V
G
T
E
R
H
E
S
R
R
I
D
N
Q
L
R
G
R
S
G
R
Q
G
D
P
G
I
T
Q
F
Y
L
S
M
E
D
E
L
M
R
R
F
G
A
E
R
T
M
A
M
L
D
R
F
G
M
D
D
S
T
P
I
Q
S
K
M
V
S
R
A
V
E
S
S
Q
K
R
V
E
G
N
N
F
D
S
R
K
Q
L
L
Q
Y
D
D
V
L
R
Q
Q
R
E
V
I
Y
----------
K
Q
R
F
E
-
V
I
-----
D
--------------
S
E
N
L
R
E
I
V
----
E
N
M
I
K
S
S
L
E
R
A
I
A
A
Y
T
P
R
E
-----
E
W
K
L
D
---
G
L
V
D
L
I
N
T
T
Y
LD
E
G
A
L
E
K
--
S
D
I
------
F
G
K
E
P
-------
D
E
M
L
E
L
I
M
D
--
R
I
I
T
K
Y
N
E
K
E
E
Q
----
F
G
K
E
Q
M
R
E
-
F
E
K
V
I
V
L
R
A
V
D
S
K
W
M
D
H
I
D
A
M
D
Q
L
R
Q
G
I
H
L
R
A
Y
A
Q
T
N
P
L
R
E
Y
Q
M
E
G
F
A
M
F
E
H
M
I
E
S
I
E
D
E
V
A
K
F
V
M
K
A
E
-------------------------------------------------------------------------------
9
PsiBlast_PDB
81.49
49%
-50
- C3 -
1M6N
7
SECA_BACSU
A:
[14-782]
---------------
R
T
L
N
-
R
Y
E
K
I
A
N
D
I
D
A
I
R
G
D
Y
E
N
L
S
D
D
A
L
K
H
K
T
I
E
F
K
E
R
L
E
------
K
G
A
T
T
D
D
L
L
V
E
A
F
A
V
V
R
E
A
S
R
R
V
T
G
M
F
P
F
K
V
Q
L
M
G
G
V
A
L
H
D
G
N
I
A
E
M
K
T
G
E
G
K
T
L
T
S
T
L
P
V
Y
L
N
A
L
T
G
K
G
V
H
V
V
T
V
N
E
Y
L
A
S
R
D
A
E
Q
M
G
K
I
F
E
F
L
G
L
T
V
G
L
N
L
N
-----------------------
S
M
S
K
D
E
--------------------------
K
R
-
E
A
Y
A
A
D
I
T
Y
S
T
N
N
E
L
G
F
D
Y
L
R
D
N
M
V
L
Y
K
E
Q
M
V
---
Q
R
---
P
L
H
F
A
V
I
D
E
V
D
S
I
L
I
D
E
A
R
T
P
L
I
I
S
G
Q
A
A
K
S
T
K
L
Y
V
Q
A
N
A
F
-----------
V
R
T
L
------------
K
A
------------
E
K
D
Y
T
Y
D
I
K
T
K
A
V
Q
L
T
E
E
G
M
T
K
A
E
K
A
F
---
G
I
----
D
N
L
F
D
V
K
H
V
A
L
N
H
H
I
N
Q
A
L
K
A
H
V
A
M
Q
K
D
V
D
Y
V
V
E
D
G
Q
V
V
I
V
D
S
F
T
G
R
L
M
K
G
R
R
Y
S
E
G
L
H
Q
A
I
----------
E
A
K
E
G
L
E
I
Q
N
E
S
M
T
L
A
T
I
T
F
Q
N
Y
F
R
M
Y
E
K
L
A
G
M
T
G
T
A
K
T
E
E
E
E
F
R
N
I
Y
N
M
Q
V
V
T
I
P
T
N
R
P
V
V
R
D
D
R
P
D
L
I
Y
R
T
M
E
G
K
F
K
A
V
A
E
D
V
A
Q
R
Y
M
T
G
Q
P
V
L
V
G
T
V
A
V
E
T
S
E
L
I
S
K
L
L
K
----------------------------------------------------------------------------
N
----------------------------------------------------------------------------
K
G
I
P
H
Q
V
L
N
A
K
N
H
E
R
E
A
Q
I
I
E
E
A
G
Q
K
G
A
V
T
I
A
T
N
M
A
G
R
G
T
D
I
K
-------
L
------------------------------------------------------------------
G
-----------------------------
E
------------------------------------------------------------------
G
V
K
-----------------------------------------
E
L
G
G
L
A
V
V
G
T
E
R
H
E
S
R
R
I
D
N
Q
L
R
G
R
S
G
R
Q
G
D
P
G
I
T
Q
F
Y
L
S
M
E
D
E
L
M
R
R
F
G
A
E
R
T
M
A
M
L
D
R
F
G
M
D
D
S
T
P
I
Q
S
K
M
V
S
R
A
V
E
S
S
Q
K
R
V
E
G
N
N
F
D
S
R
K
Q
L
L
Q
Y
D
D
V
L
R
Q
Q
R
E
V
I
Y
----------
K
Q
R
F
E
-
V
I
-----
D
--------------
S
E
N
L
R
E
I
V
----
E
N
M
I
K
S
S
L
E
R
A
I
A
A
Y
T
P
R
E
E
L
P
E
-
E
W
K
L
D
---
G
L
V
D
L
I
N
T
T
Y
LD
E
G
A
L
E
K
--
S
D
I
------
F
G
K
E
P
-------
D
E
M
L
E
L
I
M
D
--
R
I
I
T
K
Y
N
E
K
E
E
Q
----
F
G
K
E
Q
M
R
E
-
F
E
K
V
I
V
L
R
A
V
D
S
K
W
M
D
H
I
D
A
M
D
Q
L
R
Q
G
I
H
L
R
A
Y
A
Q
T
N
P
L
R
E
Y
Q
M
E
G
F
A
M
F
E
H
M
I
E
S
I
E
D
E
V
A
K
F
V
M
K
A
E
I
E
N
N
L
E
R
E
E
V
V
Q
G
Q
T
T
A
H
Q
P
Q
E
G
--------------------------------------------------------
10
PsiBlast_PDB
81.41
49%
-50
- C3 -
1M74
7
SECA_BACSU
A:
[14-782]
---------------
R
T
L
N
-
R
Y
E
K
I
A
N
D
I
D
A
I
R
G
D
Y
E
N
L
S
D
D
A
L
K
H
K
T
I
E
F
K
E
R
L
E
------
K
G
A
T
T
D
D
L
L
V
E
A
F
A
V
V
R
E
A
S
R
R
V
T
G
M
F
P
F
K
V
Q
L
M
G
G
V
A
L
H
D
G
N
I
A
E
M
K
T
G
E
G
K
T
L
T
S
T
L
P
V
Y
L
N
A
L
T
G
K
G
V
H
V
V
T
V
N
E
Y
L
A
S
R
D
A
E
Q
M
G
K
I
F
E
F
L
G
L
T
V
G
L
N
L
N
-----------------------
S
M
S
K
D
E
--------------------------
K
R
-
E
A
Y
A
A
D
I
T
Y
S
T
N
N
E
L
G
F
D
Y
L
R
D
N
M
V
L
Y
K
E
Q
M
V
---
Q
R
---
P
L
H
F
A
V
I
D
E
V
D
S
I
L
I
D
E
A
R
T
P
L
I
I
S
G
Q
A
A
K
S
T
K
L
Y
V
Q
A
N
A
F
-----------
V
R
T
L
------------
K
A
------------
E
K
D
Y
T
Y
D
I
K
T
K
A
V
Q
L
T
E
E
G
M
T
K
A
E
K
A
F
---
G
I
----
D
N
L
F
D
V
K
H
V
A
L
N
H
H
I
N
Q
A
L
K
A
H
V
A
M
Q
K
D
V
D
Y
V
V
E
D
G
Q
V
V
I
V
D
S
F
T
G
R
L
M
K
G
R
R
Y
S
E
G
L
H
Q
A
I
----------
E
A
K
E
G
L
E
I
Q
N
E
S
M
T
L
A
T
I
T
F
Q
N
Y
F
R
M
Y
E
K
L
A
G
M
T
G
T
A
K
T
E
E
E
E
F
R
N
I
Y
N
M
Q
V
V
T
I
P
T
N
R
P
V
V
R
D
D
R
P
D
L
I
Y
R
T
M
E
G
K
F
K
A
V
A
E
D
V
A
Q
R
Y
M
T
G
Q
P
V
L
V
G
T
V
A
V
E
T
S
E
L
I
S
K
L
L
K
----------------------------------------------------------------------------
N
----------------------------------------------------------------------------
K
G
I
P
H
Q
V
L
N
A
K
N
H
E
R
E
A
Q
I
I
E
E
A
G
Q
K
G
A
V
T
I
A
T
N
M
A
G
R
G
T
D
I
K
-------
L
------------------------------------------------------------------
G
-----------------------------
E
------------------------------------------------------------------
G
V
K
-----------------------------------------
E
L
G
G
L
A
V
V
G
T
E
R
H
E
S
R
R
I
D
N
Q
L
R
G
R
S
G
R
Q
G
D
P
G
I
T
Q
F
Y
L
S
M
E
D
E
L
M
R
R
F
G
A
E
R
T
M
A
M
L
D
R
F
G
M
D
D
S
T
P
I
Q
S
K
M
V
S
R
A
V
E
S
S
Q
K
R
V
E
G
N
N
F
D
S
R
K
Q
L
L
Q
Y
D
D
V
L
R
Q
Q
R
E
V
I
Y
----------
K
Q
R
F
E
-
V
I
-----
D
--------------
S
E
N
L
R
E
I
V
----
E
N
M
I
K
S
S
L
E
R
A
I
A
A
Y
T
P
R
E
E
L
P
E
-
E
W
K
L
D
---
G
L
V
D
L
I
N
T
T
Y
LD
E
G
A
L
E
K
--
S
D
I
------
F
G
K
E
P
-------
D
E
M
L
E
L
I
M
D
--
R
I
I
T
K
Y
N
E
K
E
E
Q
----
F
G
K
E
Q
M
R
E
-
F
E
K
V
I
V
L
R
A
V
D
S
K
W
M
D
H
I
D
A
M
D
Q
L
R
Q
G
I
H
L
R
A
Y
A
Q
T
N
P
L
R
E
Y
Q
M
E
G
F
A
M
F
E
H
M
I
E
S
I
E
D
E
V
A
K
F
V
M
K
A
E
I
E
N
N
L
E
R
E
E
V
V
Q
G
Q
T
T
A
H
Q
P
Q
E
G
--------------------------------------------------------
25
PsiBlast_CBE
45.76
54%
-25
- C3 -
3BXZ
3
SECA_ECOLI
B:
[200-458]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
Q
R
K
L
H
Y
A
L
VDEVDSILID
E
A
R
T
P
L
I
I
------
L
A
S
I
T
F
Q
N
Y
F
R
L
Y
E
K
L
A
G
M
T
G
T
A
D
T
E
A
F
E
F
S
S
I
Y
K
L
D
T
V
V
V
P
T
N
R
P
M
I
R
K
D
L
P
D
L
V
Y
M
T
E
A
E
K
I
Q
A
I
I
E
D
I
K
E
R
T
A
K
G
Q
P
V
L
V
G
T
I
S
I
E
K
S
E
L
V
S
N
E
L
T
----------------------------------------------------------------------------
K
----------------------------------------------------------------------------
A
G
I
K
H
N
V
L
N
A
K
F
H
A
N
E
A
A
I
V
A
Q
A
G
Y
P
A
A
V
T
I
A
T
N
M
A
G
R
G
T
D
I
V
-------
L
------------------------------------------------------------------
G
GSWQAEVAALENPTAEQIEKIKADWQVRH
D
------------------------------------------------------------------
A
V
L
-----------------------------------------
E
A
G
G
L
H
I
I
G
T
E
R
H
E
S
R
R
I
D
N
Q
L
R
G
R
S
G
R
Q
G
D
A
G
S
S
R
F
Y
L
S
M
E
D
A
L
M
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
44.88
54%
-21
- C3 -
3BXZ
3
SECA_ECOLI
A:
[200-456]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
Q
R
K
L
H
Y
A
L
V
D
EVDSILID
E
A
R
T
P
L
I
I
------
L
A
S
I
T
F
Q
N
Y
F
R
L
Y
E
K
L
A
G
M
T
G
T
A
D
T
E
A
F
E
F
S
S
I
Y
K
L
D
T
V
V
V
P
T
N
R
P
M
I
R
K
D
L
P
D
L
V
Y
M
T
E
A
E
K
I
Q
A
I
I
E
D
I
K
E
R
T
A
K
G
Q
P
V
L
V
G
T
I
S
I
E
K
S
E
L
V
S
N
E
L
T
----------------------------------------------------------------------------
K
----------------------------------------------------------------------------
A
G
I
K
H
N
V
L
N
A
K
F
H
A
N
E
A
A
I
V
A
Q
A
G
Y
P
A
A
V
T
I
A
T
N
M
A
G
R
G
T
D
I
V
-------
L
------------------------------------------------------------------
G
GS
W
Q
A
E
V
A
A
LENPTAE
Q
I
E
K
I
K
A
D
W
Q
V
R
H
D
------------------------------------------------------------------
A
V
L
-----------------------------------------
E
A
G
G
L
H
I
I
G
T
E
R
H
E
S
R
R
I
D
N
Q
L
R
G
R
S
G
R
Q
G
D
A
G
S
S
R
F
Y
L
S
M
E
D
A
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------