@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_0760: (2015-12-18 )
MADLLSSLKNLSSSSGVYQYFDKNRQLLYIGKAKNLKKRIKSYFSVRNNEITPNPRTSLRVQMMVKQIAFLETILVENEQDALILENSLIKQLKPKYNILLRDDKTYPYIYMDFSIDFPIPLITRKILKQPGVKYFGPFTSGAKDILDSLYELLPLVQKKNCIKDKKACMFYQIERCKAPCEDKITKEEYLKIAKECLEMIENKDRLIKELELKMERLSSNLRFEEALIYRDRIAKIQKIAPFTCMDLAKLYDLDIFAFYGGNNKAVLVKMFMRGGKIISSAFEKIHSLNGFDTDEAMKQAIINHYQSHLPLMPEQILLSACSNETLKELQEFISHQYSKKIALSIPKKGDKLALIEIAMKNAQEIFSQEKTSNEDRILEEARSLFNLECVPYRVEIFDTSHHSNSQCVGGMVVYENNAFQKDSYRRYHLKGSNEYDQMSELLTRRALDFAKEPPPNLWVIDGGRAQLNIALEILKSSGSFVEVIAISKEKRDSKAYRSKGGAKDIIHTISHTFKLLPSDKRLQWVQKLRDESHRYAINFHRSTKLKNMKQIALLKEKGIGEASVKKLLDYFGSFEAIEKASDQEKNAVLKKRK
Atome Classification :
(20 SA)
---.-.......------------.10.....-----------...20....-----....30........40........50.....-...60......--..70........80---------........----.90..-......----------100.......110.---.-----------.....----120.....-..----130.......140.......150...---------....160.......170----------.......180..--.....190..-----.....200......---.210---........220.....----------..230.......240---........250--------.........----260.......270....-----..------.280.......290.......-------300.......310...------....320..-------.-....330..--.....340.......-350.......360.......370.........380.......390.......400------.-......-------410.......420.......430-......--..---------------440.......450.--......460.-------------.....---------.470.......-480.......490.......500......-----.510.......---520-.......-----------530.......540.......550--.......560-.........570.......580-------.......590..----------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
---
M
-
A
D
L
L
S
S
L
------------
K
NLSSSS
G
-----------
V
Y
Q
Y
FDKN
R
-----
Q
L
L
Y
IG
K
A
K
N
L
K
K
R
I
K
S
Y
F
S
VRNNEITPNPR-
T
S
L
R
V
Q
M
M
V
K
Q
--
I
A
F
L
E
T
I
L
VENEQ----------
D
A
L
I
L
E
N
S
----
L
I
K
QL-KPK
Y
N
I
----------
L
L
RDDKT
Y
P
Y
I
Y
M
D
---
F
-----------SIDFP----
I
P
L
I
T
R
K
I
-
L
K----QPG
V
K
Y
FGPFTS
G
A
K
D
I
L
D
S
L
Y
E
L
L
P
---------
L
V
Q
K
K
N
CI
K
D
K
K
A
C
M
F
Y
----------
Q
I
E
R
CKAPCEDK--I
T
K
E
E
Y
L
K
I
A
-----
K
E
C
L
E
M
I
E
N
K
D
R
L
I
---
K
E
L
----
E
L
K
M
E
R
L
SSNL
R
F
E
E
A
----------
L
I
Y
R
D
R
I
A
K
I
Q
KIA----P
F
T
C
M
D
L
A
K
----------
L
YD
L
D
I
F
A
F
----YGGN
N
K
A
V
L
V
K
M
F
M
RG
G
-----
K
I
------
I
S
S
A
F
E
K
I
H
SLNGF
D
T
D
E
A
M
K
-------
Q
A
I
I
N
H
Y
Q
S
HLPLM
P
E
------
Q
I
L
L
S
ACS
N
-------
E
-
T
L
K
E
L
Q
E
F
I
--
S
H
Q
YS
K
K
I
A
L
SIPKK-G
D
K
L
A
L
I
E
I
A
M
K
N
A
Q
E
I
F
S
QE--KTS
N
E
D
R
I
L
E
E
A
R
S
L
FNLEC
V
P
Y
R
V
E
I
F
DTSH------H-SNSQ
C
V
-------
G
G
M
V
V
YENNAFQKDS
Y
R
R
Y
H
LK--GSN
E
Y
D
--
Q
M
---------------
S
E
L
L
T
R
R
A
L
D
FAKE--PPP
N
L
W
V
IDG-------------G
R
A
Q
L
---------
N
I
A
L
E
I
L
KSSG-
S
F
V
E
V
I
A
ISKEKR
D
S
K
A
YRSKGG
A
K
D
I
I
H
-----
T
I
S
H
T
F
KLLPS---
D
K
R
-
L
Q
W
V
Q
K
L
-----------RDESH
R
Y
A
I
N
FHRST
K
L
K
N
M
K
Q
I
--
A
L
L
K
EKGI---
G
E
A
S
V
K
K
L
L
D
Y
FG
S
F
E
A
I
E
KAS-------
D
Q
E
K
N
A
V
LKKRK----------------------------------------------------------------------------------------------------------------
28
HHSearch
68.25
34%
-63
* C4 *
2NRT
5
A:
[6-207]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
A
L
E
E
L
M
K
L
L
N
M
K
D
F
P
Y
R
I
E
G
I
D
I
S
H
------
L
-
Q
G
K
Y
T
V
-------
A
S
L
V
V
F
E
D
G
F
P
K
K
G
D
Y
R
R
Y
K
I
E
Q
D
H
P
D
D
Y
E
--
S
I
---------------
R
T
V
V
K
R
R
Y
S
K
---
H
--
P
L
P
N
L
L
F
V
D
G
-------------
G
I
G
Q
V
---------
N
A
A
I
E
A
L
K
E
I
G
-
K
D
C
P
V
V
G
L
A
K
K
E
------------
E
T
V
V
F
-----
E
N
R
-
E
I
H
L
P
H
D
---
H
P
V
-
L
R
L
L
V
Q
I
-----------
R
D
E
T
H
R
F
A
V
S
Y
H
R
K
R
R
E
K
E
S
L
R
S
--
V
L
D
N
V
P
G
I
---
G
P
I
R
K
K
K
L
I
E
H
F
G
S
L
E
N
I
R
S
A
S
-------
L
E
E
I
A
R
V
I
G
S
T
E
----------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
67.53
33%
-64
- C4 -
2NRT
5
A:
[9-206]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
E
L
M
K
L
L
N
M
K
D
F
P
Y
R
I
E
G
I
D
I
S
H
------
L
-
Q
G
K
Y
T
V
-------
A
S
L
V
V
F
E
D
G
F
P
K
K
G
D
Y
R
R
Y
K
I
E
Q
D
H
P
D
D
Y
E
--
S
I
---------------
R
T
V
V
K
R
R
---
Y
S
K
H
--
P
L
P
N
L
L
F
V
D
G
-------------
G
I
G
Q
V
---------
N
A
A
I
E
A
L
K
E
I
G
-
K
D
C
P
V
V
G
L
A
K
-
K
E
E
T
V
V
F
E
N
R
E
-----
I
H
-------------
L
P
H
---
D
H
P
V
L
R
L
L
V
Q
I
-----------
R
D
E
T
H
R
F
A
V
S
Y
H
R
K
R
R
E
K
E
S
L
R
S
--
V
L
D
N
V
P
G
I
---
G
P
I
R
K
K
K
L
I
E
H
F
G
S
L
E
N
I
R
S
A
S
-------
L
E
E
I
A
R
V
I
G
S
T
E
----------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
66.80
33%
-63
- C4 -
2NRX
5
UVRC_THEMA
A:
[9-206]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
E
L
M
K
L
L
N
M
K
D
F
P
Y
R
I
E
G
I
D
I
S
H
------
L
-
Q
G
K
Y
T
V
-------
A
S
L
V
V
F
E
D
G
F
P
K
K
G
D
Y
R
R
Y
K
I
E
Q
D
H
P
D
D
Y
E
--
S
I
---------------
R
T
V
V
K
R
R
---
Y
S
K
H
--
P
L
P
N
L
L
F
V
D
G
-------------
G
I
G
Q
V
---------
N
A
A
I
E
A
L
K
E
I
G
-
K
D
C
P
V
V
G
L
A
K
-
K
E
E
T
V
V
F
E
N
R
E
-----
I
H
-------------
L
P
H
---
D
H
P
V
L
R
L
L
V
Q
I
-----------
R
D
E
T
H
R
F
A
V
S
Y
H
R
K
R
R
E
K
E
S
L
R
S
--
V
L
D
N
V
P
G
I
---
G
P
I
R
K
K
K
L
I
E
H
F
G
S
L
E
N
I
R
S
A
S
-------
L
E
E
I
A
R
V
I
G
S
T
E
----------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
66.77
33%
-66
- C4 -
2NRZ
2
UVRC_THEMA
A:
[9-206]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
E
L
M
K
L
L
N
M
K
D
F
P
Y
R
I
E
G
I
D
I
S
H
------
L
-
Q
G
K
Y
T
V
-------
A
S
L
V
V
F
E
D
G
F
P
K
K
G
D
Y
R
R
Y
K
I
E
Q
D
H
P
D
D
Y
E
--
S
I
---------------
R
T
V
V
K
R
R
---
Y
S
K
H
--
P
L
P
N
L
L
F
V
D
G
-------------
G
I
G
Q
V
---------
N
A
A
I
E
A
L
K
E
I
G
-
K
D
C
P
V
V
G
L
A
K
-
K
E
E
T
V
V
F
E
N
R
E
-----
I
H
-------------
L
P
H
---
D
H
P
V
L
R
L
L
V
Q
I
-----------
R
D
E
T
H
R
F
A
V
S
Y
H
R
K
R
R
E
K
E
S
L
R
S
--
V
L
D
N
V
P
G
I
---
G
P
I
R
K
K
K
L
I
E
H
F
G
S
L
E
N
I
R
S
A
S
-------
L
E
E
I
A
R
V
I
G
S
T
E
----------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
66.55
33%
-62
- C4 -
2NRV
1
B:
[9-206]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
E
L
M
K
L
L
N
M
K
D
F
P
Y
R
I
E
G
I
D
I
S
H
------
L
-
Q
G
K
Y
T
V
-------
A
S
L
V
V
F
E
D
G
F
P
K
K
G
D
Y
R
R
Y
K
I
E
QD
H
P
D
D
Y
E
--
S
I
---------------
R
T
V
V
K
R
R
---
Y
S
K
H
--
P
L
P
N
L
L
F
V
D
G
-------------
G
I
G
Q
V
---------
N
A
A
I
E
A
L
K
E
I
G
-
K
D
C
P
V
V
G
L
A
K
-
K
E
E
T
V
V
F
E
N
R
E
-----
I
H
-------------
L
P
H
---
D
H
P
V
L
R
L
L
V
Q
I
-----------
R
D
E
T
H
R
F
A
V
S
Y
H
R
K
R
R
E
K
E
S
L
R
S
--
V
L
D
-
V
P
G
I
---
G
P
I
R
K
K
K
L
I
E
H
F
G
S
L
E
N
I
R
S
A
S
-------
L
E
E
I
A
R
V
I
G
S
T
E
----------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
66.54
33%
-73
- C4 -
2NRW
-
UVRC_THEMA
A:
[347-544]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
E
L
M
K
L
L
N
M
K
D
F
P
Y
R
I
E
G
I
D
I
S
H
------------
T
V
-------
A
S
L
V
V
F
E
D
G
F
P
K
K
G
D
Y
R
R
Y
K
I
E
Q---
D
D
Y
E
--
S
I
---------------
R
T
V
V
K
R
R
---
Y
S
K
H
--
P
L
P
N
L
L
F
V
D
G
-------------
G
I
G
Q
V
---------
N
A
A
I
E
A
L
K
E
I
G
-
K
D
C
P
V
V
G
L
A
K
-
K
E
E
T
V
V
F
E
N
R
E
-----
I
H
-------------
L
P
H
---
D
H
P
V
L
R
L
L
V
Q
I
-----------
R
D
E
T
H
R
F
A
V
S
Y
H
R
-----
E
S
L
R
S
--
V
L
D
N
V
P
G
I
---
G
P
I
R
K
K
K
L
I
E
H
F
G
S
L
E
N
I
R
S
A
S
-------
L
E
E
I
A
R
V
I
--------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
66.19
33%
-58
- C4 -
2NRV
-
UVRC_THEMA
A:
[9-206]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
E
L
M
K
L
L
N
M
K
D
F
P
Y
R
I
E
G
I
D
I
S
H
------
L
-
Q
G
K
Y
T
V
-------
A
S
L
V
V
F
E
D
G
F
P
K
K
G
D
Y
R
R
Y
K
I
E
Q
D
H
P
D
D
Y
E
--
S
I
---------------
R
T
V
V
K
R
R
---
Y
S
K
H
--
P
L
P
N
L
L
F
V
D
G
-------------
G
I
G
Q
V
---------
N
A
A
I
E
A
L
K
E
I
G
-
K
D
C
P
V
V
G
L
A
K
-
K
E
E
T
V
V
F
E
N
R
E
-----
I
H
-------------
L
P
H
---
D
H
P
V
L
R
L
L
V
Q
I
-----------
R
D
E
T
H
R
F
A
V
S
Y
H
R
K
R
R
E
K
E
S
L
R
S
--
V
L
D
N
V
P
G
I
---
G
P
I
R
K
K
K
L
I
E
H
F
G
S
L
E
N
I
R
S
A
S
-------
L
E
E
I
A
R
V
I
G
S
T
E
----------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
65.76
33%
-65
- C4 -
2NRZ
2
B:
[9-206]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
E
L
M
K
L
L
N
M
K
D
F
P
Y
R
I
E
G
I
D
I
S
H
------
L
-
Q
G
K
Y
T
V
-------
A
S
L
V
V
F
E
D
G
F
P
K
K
G
D
Y
R
R
Y
K
I
E
Q
D
H
P
D
D
Y
E
--
S
I
---------------
R
T
V
V
K
R
R
---
Y
S
K
H
--
P
L
P
N
L
L
F
V
D
G
-------------
G
I
G
Q
V
---------
N
A
A
I
E
A
L
K
E
I
G
-
K
D
C
P
V
V
G
L
A
K
-
K
E
E
T
V
V
F
E
N
R
E
-----
I
H
-------------
L
P
H
---
D
H
P
V
L
R
L
L
V
Q
I
-----------
R
D
E
T
H
R
F
A
V
S
Y
H
R
-----
E
S
L
R
S
--
V
L
D
N
V
P
G
I
---
G
P
I
R
K
K
K
L
I
E
H
F
G
S
L
E
N
I
R
S
A
S
-------
L
E
E
I
A
R
V
I
G
S
T
E
----------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
65.70
33%
-68
- C4 -
2NRX
4
B:
[9-206]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
E
L
M
K
L
L
N
M
K
D
F
P
Y
R
I
E
G
I
D
I
S
H
------
L
-
Q
G
K
Y
T
V
-------
A
S
L
V
V
F
E
D
G
F
P
K
K
G
D
Y
R
R
Y
K
I
E
Q
D
H
P
D
D
Y
E
--
S
I
---------------
R
T
V
V
K
R
R
---
Y
S
K
H
--
P
L
P
N
L
L
F
V
D
G
-------------
G
I
G
Q
V
---------
N
A
A
I
E
A
L
K
E
I
G
-
K
D
C
P
V
V
G
L
A
---
E
E
T
V
V
F
E
N
R
E
-----
I
H
-------------
L
P
H
---
D
H
P
V
L
R
L
L
V
Q
I
-----------
R
D
E
T
H
R
F
A
V
S
Y
H
R
------
S
L
R
S
--
V
L
D
N
V
P
G
I
---
G
P
I
R
K
K
K
L
I
E
H
F
G
S
L
E
N
I
R
S
A
S
-------
L
E
E
I
A
R
V
I
G
S
T
E
----------------------------------------------------------------------------------------------------------------
54
Fugue
65.10
25%
48
- C4 -
3C65
-
UVRC_GEOKA
A:
[-4-523]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
R
L
G
I
P
-
A
P
R
R
I
E
A
F
D
N
S
N
------
I
-
Y
G
A
D
P
V
-------
S
A
L
V
V
F
L
D
G
K
P
A
K
K
E
Y
R
K
Y
K
V
K
--
T
V
A
G
P
N
D
Y
E
T
M
--------------
R
E
V
V
R
R
R
Y
T
R
V
L
K
E
GL
P
L
P
D
L
I
I
I
D
G
-------------
G
K
G
H
L
---------
S
A
V
R
D
V
L
E
N
E
L
G
L
D
V
P
L
A
G
L
S
E
L
L
A
G
D
P
--------------------
P
D
V
V
P
L
D
R
Q
---
S
Q
E
-
F
Y
L
L
Q
R
I
-----------
Q
D
E
V
H
R
F
A
V
M
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
Fugue
59.30
34%
-49
- C4 -
2NRR
-
UVRC_THEMA
A:
[344-494]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
A
L
E
E
L
M
K
L
L
N
M
K
D
F
P
Y
R
I
E
G
I
D
I
S
H
----------
L
Y
T
V
-------
A
S
L
V
V
F
E
D
G
F
P
K
K
G
D
Y
R
R
Y
K
I
-----
D
D
Y
E
--
S
I
---------------
R
T
V
V
K
R
R
Y
---
S
K
H
--
P
L
P
N
L
L
F
V
D
G
-------------
G
I
G
Q
V
---------
N
A
A
I
E
A
L
K
E
I
G
-
K
D
C
P
V
V
G
L
A
T
V
V
F
E
N
----------------------
R
E
I
H
L
P
H
D
---
H
P
V
-
L
R
L
L
V
Q
I
-----------
R
D
E
T
H
R
F
A
V
S
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
Fugue
52.64
15%
-54
- C1 -
3UGM
-
PTHX1_XANOP
A:
[169-1048]
KPK
V
-
R
E
L
V
A
H
I
------------
V
A
L
S
Q
H
P
A
ALGTVAVTYQH
I
I
T
A
L
A
T
H
E
-----
D
I
V
G
V
G
K
Q
W
S
G
A
R
A
L
E
A
L
L
T
D
A
G
E
L
R
G
P
P
L
Q
L
D
T
G
Q
L
V
K
I
A
K
R
GG
V
T
A
M
E
A
V
H
A
S
R
N
A
LTPLNLT
P
A
Q
V
V
A
I
A
S
N
N
G
G
K
Q
A
L
E
T
V
-
Q
R
L
L
P
V
----------
L
C
Q
A
H
G
L
T
P
A
Q
V
V
A
---
I
A
SHDG
G
K
Q
A
L
E
T
M
Q
R
L
----
L
P
V
L
C
Q
A
H
G
L
P
----
P
D
Q
V
V
A
I
A
S
-
N
I
G
G
K
Q
A
L
E
T
V
Q
R
L
L
P
---------
V
L
C
Q
A
H
G
L
T
P
D
Q
V
V
A
I
A
SHGG
G
K
Q
A
L
E
T
V
Q
R
L
L
P
V
L
C
Q
A
HG
L
T
P
D
Q
V
V
A
I
A
SHDG
G
K
Q
A
L
E
T
V
Q
R
L
L
P
V
L
---
C
Q
A
HGLT
P
D
Q
V
V
A
I
A
S
N
G
G
G
K
Q
A
----------
L
E
T
V
Q
R
L
L
P
V
L
C
Q
A
HGLT
P
D
Q
V
V
A
I
A
S
NGG
K
Q
A
L
E
T
V
Q
R
L
L
P
V
L
C
Q
----
A
H
G
L
T
P
D
Q
V
V
A
I
A
S
H
D
G
G
K
Q
A
L
E
T
------
V
Q
R
L
L
P
V
L
C
Q
T
H
G
L
T
P
A
Q
V
V
A
I
A
SHDG
G
K
Q
A
L
E
T
V
Q
Q
L
L
P
V
L
C
Q
AHGLT
P
D
Q
V
V
A
I
A
S
N
IG
G
K
Q
A
L
A
-
T
V
Q
R
L
L
P
V
L
CQ
A
H
G
L
T
P
D
Q
V
V
A
I
A
S
N
-
G
G
G
K
Q
A
L
E
T
V
Q
R
L
L
P
V
L
C
Q
A
H
GL
T
P
D
Q
V
V
A
I
A
S
N
G
G
G
K
Q
A
L
E
T
V
Q
R
L
L
P
V
L
C
Q
A
H
------
G
L
T
Q
V
Q
V
V
AIASNIG
G
K
Q
A
L
E
T
V
Q
R
L
L
P
V
L
C
Q
A
H
G
L
T
--
P
A
Q
V
V
A
--
I
A
---------------
S
H
D
G
G
K
Q
A
L
E
T
V
Q
R
--
L
L
P
V
L
C
Q
A
H
G
LT
P
D
Q
V
V
A
IASNG
G
G
K
Q
A
---------
L
E
T
V
Q
R
L
L
P
G
L
-
T
Q
E
Q
V
V
A
I
A
S
N
N
G
G
K
Q
A
L
E
T
V
Q
R
L
L
P
V
L
C
Q
AHGL
T
P
D
Q
V
V
A
I
A
S
N
GG
G
K
Q
A
-
L
E
T
V
Q
R
L
LPVLCQAHGLT
P
A
Q
V
V
A
I
A
S
N
I
G
G
K
Q
A
L
E
T
V
Q
R
L
L
P
V
L
C
Q
D
H
G
L
---
T
L
A
Q
V
V
A
I
A
S
N
I
G
G
K
Q
A
L
E
T
V
Q
-------
R
L
L
P
V
L
C
Q
G
L
T
Q
D
Q
V
V
A
I
A
SNIG
G
K
Q
A
L
E
T
V
Q
R
LLPVLCQDHGLT
P
D
Q
V
V
A
I
A
S
NIGGKQ
A
L
E
T
V
Q
R
L
L
PVLCQDHGLT
L
D
Q
V
V
A
I
A
S
N
GGK
Q
A
L
E
T
V
Q
R
L
L
P
V
L
C
Q
DHGLTPDQVVAIASNSG
61
Fugue
51.58
16%
-21
- C5 -
3HJH
1
MFD_ECOLI
A:
[5-450]
-------------------------------
Y
-----------
R
Y
T
L
P
V
K
A
G
-----
E
Q
R
L
L
G
E
L
-------------------
T
G
A
A
-
C
A
T
L
V
A
E
I
A
E
R
--
H
A
G
P
V
V
L
I
A
P
D
M
Q
----------
N
A
L
R
L
H
D
E
----
I
S
Q
F
T
-
D
Q
M
V
M
N
----------
L
-
A
D
W
E
T
L
P
Y
-----------------------------------------------
D
S
F
S
P
H
Q
D
I
I
S
S
R
L
S
T
L
Y
Q
L
P
T
------------------
M
Q
R
G
V
L
I
V
----------
P
V
N
T
L
M
----
Q
R
--
V
C
P
H
S
F
L
H
G
H
-----
A
L
V
M
K
K
G
Q
R
L
S
--
R
---
D
A
L
----
R
T
Q
L
D
S
--
A
G
Y
R
H
V
D
Q
----------
V
M
E
H
G
E
Y
A
T
R
G
A
L
L
----
D
L
F
P
M
G
S
E
L
----------
P
Y
R
L
D
F
F
D
----------------------------------------
D
E
I
D
S
L
R
V
F
D
V
D
S
Q
R
T
-------
L
E
E
V
E
----
A
I
N
L
L
P
A
------
H
E
F
P
T
--
D
K
-------
A
-
A
I
E
L
F
R
S
Q
W
--
R
D
T
F
E
V
K
--------------------
R
D
P
E
H
I
Y
Q
Q
V
--
S
K
G
T
L
P
A
G
I
E
Y
W
Q
P
L
F
F
S
E
P
L
P
---
P
L
F
S
Y
F
P
------
A
-
N
T
L
L
V
N
-------
T
G
D
L
E
T
S
A
E
R
F
Q
A
D
T
L
A
R
F
E
N
R
-----
G
V
D
--
P
M
---------------
R
P
L
L
------------
P
P
Q
S
L
W
--------------------------------
L
R
V
D
E
L
F
S
E
L
-
K
N
W
P
R
V
Q
L
K
T
E
H
L
P
T
K
A
A
N
A
N
L
G
F
Q
K
L
P
D
-----
L
A
V
Q
A
Q
Q
K
A
P
L
---
D
A
L
-
R
K
F
L
E
T
----------------
F
D
G
P
V
V
F
S
V
E
S
E
G
R
R
E
A
L
G
--
E
L
L
A
R
I
K
I
---
A
P
Q
R
I
M
R
L
D
E
A
S
D
R
G
R
Y
L
M
I
G
A
AE
H
G
F
V
D
T
V
R
N
L
A
L
I
C
E
S
D
LL--------------------------------------------------------------------------------------------------------------
31
HHSearch
49.10
42%
-39
- C4 -
1YD6
3
UVRC_GEOKA
A:
[3-95]
-----
E
R
L
K
E
K
L
------------
A
V
L
P
E
Q
P
G
-----------
C
Y
L
M
K
D
K
H
G
-----
T
V
I
Y
V
G
K
A
K
S
L
K
E
R
V
R
S
Y
F
T
G
T
----------
H
D
G
K
T
Q
R
L
V
E
E
--
I
A
D
F
E
Y
I
V
T
S
S
N
A
----------
E
A
L
I
L
E
M
N
----
L
I
K
K
H
-
D
P
K
Y
N
V
----------
M
L
K
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
Fugue
48.36
38%
-44
- C4 -
1YD0
5
UVRC_THEMA
A:
[1-89]
---
M
K
E
K
I
R
K
K
I
------------
L
L
A
P
E
E
P
G
-----------
V
Y
I
F
K
N
K
G
------
V
P
I
Y
I
G
K
A
K
R
L
S
N
R
L
R
S
Y
L
N
----------
P
-
Q
T
E
K
V
F
R
I
G
E
E
--
A
D
E
L
E
T
I
V
V
M
N
E
R
----------
E
A
F
I
L
E
A
N
----
L
I
K
K
Y
-
R
P
K
Y
N
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
48.17
37%
-38
- C4 -
1YD0
5
UVRC_THEMA
A:
[3-89]
-----
E
K
I
R
K
K
I
------------
L
L
A
P
E
E
P
G
-----------
V
Y
I
F
K
N
-
K
G
-----
V
P
I
Y
I
G
K
A
K
R
L
S
N
R
L
R
S
Y
L
N
P
Q
-----------
T
E
K
V
F
R
I
G
E
E
--
A
D
E
L
E
T
I
V
V
M
N
E
R
----------
E
A
F
I
L
E
A
N
----
L
I
K
K
Y
-
R
P
K
Y
N
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
48.04
39%
-34
- C4 -
1YD6
3
UVRC_GEOKA
D:
[5-97]
-------
L
K
E
K
L
------------
A
V
L
P
E
Q
P
G
-----------
C
Y
L
M
K
D
K
H
G
-----
T
V
I
Y
V
G
K
A
K
S
L
K
E
R
V
R
S
Y
F
T
G
T
H
D
G
----------
K
T
Q
R
L
V
E
E
--
I
A
D
F
E
Y
I
V
T
S
S
N
A
----------
E
A
L
I
L
E
M
N
----
L
I
K
K
H
-
D
P
K
Y
N
V
----------
M
L
K
D
D
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
47.61
39%
-35
- C4 -
1YD6
3
UVRC_GEOKA
A:
[5-95]
-------
L
K
E
K
L
------------
A
V
L
P
E
Q
P
G
-----------
C
Y
L
M
K
D
K
H
G
-----
T
V
I
Y
V
G
K
A
K
S
L
K
E
R
V
R
S
Y
F
T
G
T
H
D
G
----------
K
T
Q
R
L
V
E
E
--
I
A
D
F
E
Y
I
V
T
S
S
N
A
----------
E
A
L
I
L
E
M
N
----
L
I
K
K
H
-
D
P
K
Y
N
V
----------
M
L
K
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
Fugue
47.13
15%
5
- C2 -
4Q35
21
LPTD_SHIFL
A:
[25-784]
-----
A
D
L
A
S
Q
C
M
L
G
VPSYD
R
P
L
V
Q
G
D
T
N
D
L
P
-----------
V
T
I
N
A
D
H
A
K
G
DYPD
D
A
V
F
T
G
S
V
D
I
M
Q
G
N
S
R
L
Q
A
D
E
V
Q
L
H
Q
K
E
A
P
G
-
Q
P
V
R
T
V
D
A
L
G
N
--
V
H
Y
D
D
N
Q
V
I
L
K
G
P
----------
K
G
W
A
N
L
N
T
----
K
D
T
N
V
W
E
G
D
Y
Q
M
V
G
R
Q
G
R
G
K
A
D
L
M
K
Q
R
G
E
N
R
Y
T
I
L
D
N
G
S
F
-----------
T
S
C
L
P
GSDT
W
S
V
V
G
S
E
I
-
I
H
D
REE
Q
V
A
E
I
W
N
A
R
F
K
V
G
P
V
P
I
F
Y
S
P
Y
L
Q
L
P
VGDKRRS
G
F
L
I
P
N
A
K
Y
T
T
T
N
Y
F
E
F
Y
L
----------
P
Y
Y
W
N
I
A
P
N
M
D
A
--
T
I
T
P
H
Y
M
--
H
-----
R
R
G
N
I
M
W
E
N
E
F
R
Y
L
S
QA
G
A
G
----
L
M
E
L
D
Y
L
P
S
D
K
V
Y
E
D
E
H
PNDDSS
R
R
W
L
F
Y
W
N
H
S
G
V
M
D
Q
V
W
----
R
F
N
-
V
D
Y
T
K
----------
V
S
D
P
S
Y
F
N
D
F
DNK
Y
G
S
S
T
D
G
Y
A
T
Q
K
F
S
V
G
Y
-----
A
V
QN
F
N
A
T
V
S
T
K
Q
F
Q
V
F
S
E
Q
N
T
S
S
Y
S
A
E
P
-------
Q
L
D
V
N
Y
Y
Q
N
D
V
G
P
F
D
T
------
R
I
Y
G
Q
A
V
H
F
-------
V
N
T
R
D
D
M
P
E
A
T
--
R
V
H
L
E
P
T
I
N
L
P
L
S
N
N
W
G
S
I
N
T
E
A
K
F
L
A
T
H
Y
Q
Q
T
N
L
D
W
--
Y
N
S
R
N
T
T
K
L
D
E
S
V
N
R
V
M
P
Q
F
K
V
D
G
K
M
V
F
E
R
D
M
EMLAPG
Y
-
T
Q
T
L
E
P
-------
R
A
Q
Y
L
Y
V
P
Y
R
D
Q
S
D
I
Y
N
Y
D
S
S
L
--
L
Q
S
D
Y
S
--
G
L
F
RDRTYGGLD
R
I
A
S
A
N
Q
V
T
T
G
V
T
S
R
I
Y
D
D
--
A
A
V
E
R
F
N
I
S
V
-------------
G
Q
I
Y
Y
F
T
E
S
R
TGDD
N
I
T
W
E
N
D
D
K
T
G
-
S
L
V
W
A
G
D
T
Y
W
R
I
S
E
R
W
G
L
R
G
G
I
Q
Y
D
T
R
L
D
-----
N
V
A
T
S
N
S
S
I
E
Y
---
R
R
D
----
E
D
R
L
-----------
V
Q
L
N
Y
H
Y
A
S
P
E
Y
I
Q
A
T
L
P
K
Y
Y
S
T
--
A
E
Q
Y
K
N
G
I
S
Q
V
G
A
V
A
S
R
P
I
A
D
R
W
S
I
V
G
A
Y
Y
Y
D
T
NA-----
N
K
Q
A
D
S
M
L
G
V
Q
Y
S
S
CC
Y
A
I
R
V
G
Y
E
R
K
LNGWDNDKQ
H
A
V
Y
D
N
A
I
G
F
N
I
E
L
R
GLSSNYGLG
T
Q
E
M
L
R
SNIL
P
Y
Q
N
TL-------------------------------------------------
25
PsiBlast_CBE
46.74
39%
-32
- C4 -
1YD6
5
UVRC_GEOKA
C:
[5-94]
-------
L
K
E
K
L
------------
A
V
L
P
E
Q
P
G
-----------
C
Y
L
M
K
D
K
H
G
-----
T
V
I
Y
V
G
K
A
K
S
L
K
E
R
V
R
S
Y
F
T
G
T
H
D
G
----------
K
T
Q
R
L
V
E
E
--
I
A
D
F
E
Y
I
V
T
S
S
N
A
----------
E
A
L
I
L
E
M
N
----
L
I
K
K
H
-
D
P
K
Y
N
V
----------
M
L
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------