@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_0768: (2015-12-18 )
MRILQRALTFEDVLMVPRKSSVLPKDVSLKSRLTKNIGLNIPFISAAMDTVTEHKTAIAMARLGGIGIVHKNMDIQTQVKEITKVKKSESGVINDPIFIHAHRTLADAKVITDNYKISGVPVVDDKGLLIGILTNRDVRFETDLSKKVGDVMTKMPLVTAHVGISLDEASDLMHKHKIEKLPIVDKDNVLKGLITIKDIQKRIEYPEANKDDFGRLRVGAAIGVGQLDRAEMLVKAGVDALVLDSAHGHSANILHTLEEIKKSLVVDVIVGNVVTKEATSDLISAGADAVKVGIGPGSICTTRIVAGVGMPQVSAIDNCVEVASKFDIPVIADGGIRYSGDVAKALALGASSVMIGSLLAGTEESPGDFMIYQGRQYKSYRGMGSIGAMTKGSSDRYFQEGVASEKLVPEGIEGRVPYRGKVSDMIFQLVGGVRSSMGYQGAKNILELYQNAEFVEITSAGLKESHVHGVDITKEAPNYYG
Atome Classification :
(49 SA)
.........10........20..--......30...-------.....40........50........60........70........80.....--...90........100.......110.......120..--.--...--.130.......140........150.-...-...160.......170.......180.......190...------------....200.......210........220..--.--.--..--.230.......240.......250.......260...--.-....270.......280.......290.......300.......310.......320...------....330.......340.......350.......360.......370.......380.......---390...--------....400........410.......420.......430.......440.....----..450-----.......460.......470.......480
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
R
I
L
Q
R
AL
T
F
E
D
V
LMVPRKSSVL--PKD
V
S
L
K
S
R
L
T
-------
K
NIGLNI
P
F
I
S
A
A
M
D
T
V
T
E
H
K
T
A
I
A
M
A
RLG
G
I
G
I
V
HKNM
D
I
Q
T
Q
V
K
E
I
T
K
V
K--KSESGVIND
P
I
F
I
H
A
HRTLAD
A
K
V
I
TDN
Y
K
ISG
V
P
VVD--D--K
G
L
--
L
I
G
I
LTNRD
V
R
F-E
T
D
L
S
K
K
V
G
D
V
M
T-KM
P
-
L
V
T
A
H
VGIS
L
D
E
A
S
D
L
M
H
K
HK
I
E
KLPIV
D
K
D
N
V
L
K
G
L
I
T
------------
I
K
D
I
Q
K
RIEYPEANK-DDFG
R
L
R
V
G
A
A
IGV--G--Q--
L
D
--
R
A
E
M
L
V
K
AGV
D
A
L
V
LDSAHGHS
A
N
I
L
H
T
L
E
E
I
K
-
K
S
L
--
V
-
V
D
V
I
VGNVV
T
K
E
A
T
S
D
L
I
SAGA
D
A
V
K
VGIGPG
S
I
C
T
T
R
I
V
AGVGM
P
Q
V
S
A
I
D
N
C
V
E
V
A
S
K------FD
I
P
V
IADGG
I
R
YS
G
D
V
A
K
A
L
A
LG
A
S
S
V
M
I
G
S
L
LAGTEESPG
D
F
M
I
YQGRQYKSYRGMGSIGAM---TKGSS
D
--------
R
Y
F
Q
EG-VASEKLVPEGIEGRVPYRG
K
V
S
D
M
I
F
Q
L
V
G
G
V
R
S
SMG
Y
Q
G
A
K
N
I
L
E
----
L
YQNA-----
E
F
V
E
ITSAGLKESHVHGVDITKEAPNYYG
6
PsiBlast_PDB
88.72
52%
-90
- C2 -
4FXS
3
?
A:
[4-486]
L
R
I
A
K
E
A
L
T
F
D
D
V
L
L
V
P
A
H
S
T
V
L
--
P
N
T
A
D
L
R
T
R
L
T
-------
K
N
I
A
L
N
I
P
M
V
S
A
S
M
D
T
V
T
E
A
R
L
A
I
A
L
A
Q
E
G
G
I
G
F
I
H
K
N
M
S
I
E
Q
Q
A
A
Q
V
H
Q
V
K
--
I
F
E
A
--
V
T
H
P
V
T
V
R
P
E
Q
T
I
A
D
V
M
E
L
T
H
Y
H
G
F
A
G
F
P
V
V
T
--
E
--
N
N
E
--
L
V
G
I
I
T
G
R
D
V
R
F
-
V
T
D
L
T
K
S
V
A
A
V
M
T
P
K
E
R
-
L
A
T
V
K
E
G
----
E
V
Q
E
K
M
H
---
V
E
K
I
L
V
V
N
D
E
F
Q
L
K
G
M
I
T
------------
A
K
-----
E
S
K
P
N
A
C
K
-
D
E
Q
G
R
L
R
V
G
A
A
V
G
A
AP
G
--
N
--
E
E
--
R
V
K
A
L
V
E
A
G
V
D
V
L
L
I
D
S
S
H
G
H
S
E
G
V
L
Q
R
I
R
E
T
R
-
A
A
Y
--
P
H
L
E
I
I
G
G
N
V
A
T
A
E
G
A
R
A
L
I
E
A
G
V
S
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
T
G
V
G
V
P
Q
I
T
A
I
A
D
A
A
G
V
A
N
E
------
Y
G
I
P
V
I
A
D
G
G
I
R
F
S
G
D
I
S
K
A
I
A
A
G
A
S
C
V
M
V
G
S
M
F
A
G
T
E
E
A
P
G
E
V
I
L
Y
Q
G
R
S
Y
K
A
Y
R
G
M
G
S
L
G
A
M
---
S
K
G
S
S
D
--------
R
Y
F
Q
T
----
A
D
K
L
V
P
E
G
I
E
G
R
I
A
Y
K
G
H
L
K
E
I
I
H
Q
Q
M
G
G
L
R
S
C
M
G
L
T
G
S
A
T
V
E
D
----
L
R
T
K
A
-----
Q
F
V
R
I
S
G
A
G
M
K
E
S
H
V
H
D
V
Q
I
T
K
E
A
P
N
Y
--
2
PsiBlast_PDB
86.64
59%
-81
- C2 -
3TSB
2
?
A:
[29-509]
-
K
F
V
K
E
G
L
T
F
D
D
V
L
L
V
P
A
K
S
D
V
L
--
P
R
E
V
S
V
K
T
V
L
S
-------
E
S
L
Q
L
N
I
P
L
I
S
A
G
M
D
T
V
T
E
A
D
M
A
I
A
M
A
R
Q
G
G
L
G
I
I
H
K
N
M
S
I
E
Q
Q
A
E
Q
V
D
K
V
K
--
R
S
E
S
G
V
I
S
D
P
F
F
L
T
P
E
H
Q
V
Y
D
A
E
H
L
M
G
K
Y
R
I
S
G
V
P
V
V
N
NL
D
--
E
R
K
--
L
V
G
I
I
T
N
R
D
M
R
F
-
I
Q
D
Y
S
I
K
I
S
D
V
M
T
-
K
E
Q
-
L
I
T
A
P
V
G
T
T
L
S
E
A
E
K
I
L
Q
K
Y
K
I
E
K
L
P
L
V
D
N
N
G
V
L
Q
G
L
I
T
------------
I
K
D
I
E
K
V
I
E
F
P
N
S
A
K
-
D
K
Q
G
R
L
L
V
G
A
A
V
G
V
--
T
--
A
D
A
M
T
--
R
I
D
A
L
V
K
A
S
V
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
P
--
S
-
L
N
I
I
A
G
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
P
Q
L
T
A
V
Y
D
C
A
T
E
A
R
K
------
H
G
I
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
E
I
Y
Q
G
R
Q
F
K
V
Y
R
G
M
G
S
V
G
A
M
---
E
K
G
S
K
D
--------
R
Y
F
Q
E
G
---
N
K
K
L
V
P
E
G
I
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
E
F
----
L
R
E
N
A
-----
Q
F
I
R
M
S
G
A
G
L
L
E
S
H
P
H
H
V
Q
I
T
K
E
A
P
N
Y
S
-
106
HHSearch
85.68
56%
-84
- C2 -
1ZFJ
1
IMDH_STRPY
A:
[6-490]
-
K
F
L
K
K
G
Y
T
F
D
D
V
L
L
I
P
A
E
S
H
V
L
--
P
N
E
V
D
L
K
T
K
L
A
-------
D
N
L
T
L
N
I
P
I
I
T
A
A
M
D
T
V
T
G
S
K
M
A
I
A
I
A
R
A
G
G
L
G
V
I
H
K
N
M
S
I
T
E
Q
A
E
E
V
R
K
V
K
--
R
S
E
N
G
V
I
I
D
P
F
F
L
T
P
E
H
K
V
S
E
A
E
E
L
M
Q
R
Y
R
I
S
G
V
P
I
V
E
--
T
LA
N
R
K
--
L
V
G
I
I
T
N
R
D
M
R
F
-
I
S
D
Y
N
A
P
I
S
E
H
M
T
-
S
E
H
-
L
V
T
A
A
V
G
T
D
L
E
T
A
E
R
I
L
H
E
H
R
I
E
K
L
P
L
V
D
N
S
G
R
L
S
G
L
I
T
------------
I
K
D
I
E
K
V
I
E
F
P
H
A
A
K
-
D
E
F
G
R
L
L
V
A
A
A
V
G
V
--
T
SD
T
--
F
E
--
R
A
E
A
L
F
E
A
G
A
D
A
I
V
I
D
T
A
H
G
H
S
A
G
V
L
R
K
I
A
E
I
R
-
A
H
F
P-
N
-
R
T
L
I
A
G
N
I
A
T
A
E
G
A
R
A
L
Y
D
A
G
V
D
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
P
Q
V
T
A
I
Y
D
A
A
A
V
A
R
E
------
Y
G
K
T
I
I
A
D
G
G
I
K
Y
S
G
D
I
V
K
A
L
A
A
G
G
N
A
V
M
L
G
S
M
F
A
G
T
D
E
A
P
G
E
T
E
I
Y
Q
G
R
K
Y
K
T
Y
R
G
M
G
S
I
A
A
M
---
K
K
----------------------
N
K
L
V
P
E
G
I
E
G
R
V
A
Y
K
G
A
A
S
D
I
V
F
Q
M
L
G
G
I
R
S
G
M
G
Y
V
G
A
G
D
I
Q
E
----
L
H
E
N
A
-----
Q
F
V
E
M
S
G
A
G
L
I
E
S
H
P
H
D
V
Q
I
T
N
E
A
P
N
Y
S
V
8
PsiBlast_PDB
85.67
54%
-96
- C2 -
4DQW
7
?
A:
[22-486]
L
R
I
S
Q
E
A
L
T
F
D
D
V
L
L
I
P
G
Y
S
E
V
L
--
P
K
D
V
S
L
K
T
R
L
T
-------
R
G
I
E
L
N
I
P
L
V
S
A
A
M
D
T
V
T
E
A
R
L
A
I
A
M
A
Q
E
G
G
I
G
I
I
H
K
N
M
G
I
E
Q
Q
A
A
E
V
R
K
V
K
--
K
H
E
T
A
I
V
R
D
P
V
T
V
T
P
S
T
K
I
I
E
L
L
Q
M
A
R
E
Y
G
F
S
G
F
P
V
V
E
-----
Q
G
E
--
L
V
G
I
V
T
G
R
D
L
R
V
-
K
P
N
A
G
D
T
V
A
A
I
M
T
P
K
D
K
-
L
V
T
A
R
E
G
T
P
L
E
E
M
K
A
K
L
Y
E
N
R
I
E
K
M
L
V
V
D
E
N
F
Y
L
R
G
L
V
T
------------
F
R
D
I
E
K
A
K
T
Y
P
L
A
S
K
-
D
E
Q
G
R
L
R
V
G
A
A
V
G
T
--
G
AD
T
--
G
E
--
R
V
A
A
L
V
A
A
G
V
D
V
V
V
V
D
T
A
H
G
H
S
K
G
V
I
E
R
V
R
W
V
K
-
Q
T
F
--
P
D
V
Q
V
I
G
G
N
I
A
T
A
E
A
A
K
A
L
A
E
A
G
A
D
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
A
G
V
G
V
P
Q
I
S
A
I
A
N
V
A
A
A
L
E
G
------
T
G
V
P
L
I
A
D
G
G
I
R
F
S
G
D
L
A
K
A
M
V
A
G
A
Y
C
V
M
M
G
S
M
F
A
G
T
E
E
A
P
G
E
------------------------------------------------------------
P
Y
K
G
A
L
S
A
I
V
H
Q
L
M
G
G
L
R
A
A
M
G
Y
T
G
S
A
D
I
Q
Q
----
M
R
T
Q
P
-----
Q
F
V
R
I
T
G
----------------------
5
PsiBlast_PDB
85.27
54%
-85
- C2 -
1ZFJ
1
IMDH_STRPY
A:
[6-489]
-
K
F
L
K
K
G
Y
T
F
D
D
V
L
L
I
P
A
E
S
H
V
L
--
P
N
E
V
D
L
K
T
K
L
A
-------
D
N
L
T
L
N
I
P
I
I
T
A
A
M
D
T
V
T
G
S
K
M
A
I
A
I
A
R
A
G
G
L
G
V
I
H
K
N
M
S
I
T
E
Q
A
E
E
V
R
K
V
K
--
R
S
E
N
G
V
I
I
D
P
F
F
L
T
P
E
H
K
V
S
E
A
E
E
L
M
Q
R
Y
R
I
S
G
V
P
I
V
E
--
T
LA
N
R
K
--
L
V
G
I
I
T
N
R
D
M
R
F
-
I
S
D
Y
N
A
P
I
S
E
H
M
T
-
S
E
H
-
L
V
T
A
A
V
G
T
D
L
E
T
A
E
R
I
L
H
E
H
R
I
E
K
L
P
L
V
D
N
S
G
R
L
S
G
L
I
T
------------
I
K
D
I
E
K
V
I
E
F
P
H
A
A
K
-
D
E
F
G
R
L
L
V
A
A
A
V
G
V
--
T
--
S
D
T
F
E
--
R
A
E
A
L
F
E
A
G
A
D
A
I
V
I
D
T
A
H
G
H
S
A
G
V
L
R
K
I
A
E
I
R
-
A
H
F
--
P
N
R
T
L
I
A
G
N
I
A
T
A
E
G
A
R
A
L
Y
D
A
G
V
D
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
P
Q
V
T
A
I
Y
D
A
A
A
V
A
R
E
------
Y
G
K
T
I
I
A
D
G
G
I
K
Y
S
G
D
I
V
K
A
L
A
A
G
G
N
A
V
M
L
G
S
M
F
A
G
T
D
E
A
P
G
E
T
E
I
Y
Q
G
R
K
Y
K
T
Y
R
G
M
G
S
I
A
A
M
---
K
K
----------------------
N
K
L
V
P
E
G
I
E
G
R
V
A
Y
K
G
A
A
S
D
I
V
F
Q
M
L
G
G
I
R
S
G
M
G
Y
V
G
A
G
D
I
Q
E
----
L
H
E
N
A
-----
Q
F
V
E
M
S
G
A
G
L
I
E
S
H
P
H
D
V
Q
I
T
N
E
A
P
N
Y
S
V
21
PsiBlast_CBE
84.81
54%
-99
- C2 -
4DQW
5
?
B:
[22-486]
L
R
I
S
Q
E
A
L
T
F
D
D
V
L
L
I
P
G
Y
S
E
V
L
--
P
K
D
V
S
L
K
T
R
L
T
-------
R
G
I
E
L
N
I
P
L
V
S
A
A
M
D
T
V
T
E
A
R
L
A
I
A
M
A
Q
E
G
G
I
G
I
I
H
K
N
M
G
I
E
Q
Q
A
A
E
V
R
K
V
K
--
K
H
E
T
A
I
V
R
D
P
V
T
V
T
P
S
T
K
I
I
E
L
L
Q
M
A
R
E
Y
G
F
S
G
F
P
V
V
E
-----
Q
G
E
--
L
V
G
I
V
T
G
R
D
L
R
V
------
D
T
V
A
A
I
M
T
P
K
D
K
-
L
V
T
A
R
E
G
T
P
L
E
E
M
K
A
K
L
Y
E
N
R
I
E
K
M
L
V
V
D
E
N
F
Y
L
R
G
L
V
T
------------
F
R
D
I
E
K
A
K
T
Y
P
L
A
S
K
-
D
E
Q
G
R
L
R
V
G
A
A
V
G
T
--
G
AD
T
--
G
E
--
R
V
A
A
L
V
A
A
G
V
D
V
V
V
V
D
T
A
H
G
H
S
K
G
V
I
E
R
V
R
W
V
K
-
Q
T
F
--
P
D
V
Q
V
I
G
G
N
I
A
T
A
E
A
A
K
A
L
A
E
A
G
A
D
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
A
G
V
G
V
P
Q
I
S
A
I
A
N
V
A
A
A
L
E
G
------
T
G
V
P
L
I
A
D
G
G
I
R
F
S
G
D
L
A
K
A
M
V
A
G
A
Y
C
V
M
M
G
S
M
F
A
G
T
E
E
A
P
------------------------------------------------------------------
A
L
S
A
I
V
H
Q
L
M
G
G
L
R
A
A
M
G
Y
T
G
S
A
D
I
Q
Q
----
M
R
T
Q
P
-----
Q
F
V
R
I
T
G
----------------------
105
HHSearch
84.62
59%
-93
- C2 -
3USB
4
?
A:
[30-493]
--
F
V
K
E
G
L
T
F
D
D
V
L
L
V
P
A
K
S
D
V
L
--
P
R
E
V
S
V
K
T
V
L
S
-------
E
S
L
Q
L
N
I
P
L
I
S
A
G
M
D
T
V
T
E
A
D
M
A
I
A
M
A
R
Q
G
G
L
G
I
I
H
K
N
M
S
I
E
Q
Q
A
E
Q
V
D
K
V
K
--
R
S
E
S
G
V
I
S
D
P
F
F
L
T
P
E
H
Q
V
Y
D
A
E
H
L
M
G
K
Y
R
I
S
G
V
P
V
V
N
--
N
LD
E
R
K
--
L
V
G
I
I
T
N
R
D
M
R
F
-
I
Q
D
Y
S
I
K
I
S
D
V
M
T
-
K
E
Q
-
L
I
T
A
P
V
G
T
T
L
S
E
A
E
K
I
L
Q
K
Y
K
I
E
K
L
P
L
V
D
N
N
G
V
L
Q
G
L
I
T
------------
I
K
D
I
E
K
V
I
E
F
P
N
S
A
K
-
D
K
Q
G
R
L
L
V
G
A
A
V
G
V
--
T
AD
A
--
M
T
--
R
I
D
A
L
V
K
A
S
V
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
-
A
K
Y
P-
S
-
L
N
I
I
A
G
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
P
Q
L
T
A
V
Y
D
C
A
T
E
A
R
K
------
H
G
I
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
E
I
Y
Q
G
R
Q
F
K
V
------------------------------------------------
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
E
F
----
L
R
E
N
A
-----
Q
F
I
R
M
S
G
A
G
L
L
------------------
10
PsiBlast_PDB
84.48
54%
-93
- C2 -
5AHN
2
?
A:
[2-467]
L
R
I
S
Q
E
A
L
T
F
D
D
V
L
L
I
P
G
Y
S
E
V
L
--
P
K
D
V
S
L
K
T
R
L
T
-------
R
G
I
E
L
N
I
P
L
V
S
A
A
M
D
T
V
T
E
A
R
L
A
I
A
M
A
Q
E
G
G
I
G
I
I
H
K
N
M
G
I
E
Q
Q
A
A
E
V
R
K
V
K
--
K
H
----------------------------------------------------------------------------------------------------------------------------------------
T
Y
P
L
A
S
K
-
D
E
Q
G
R
L
R
V
G
A
A
V
G
T
--
G
AD
T
--
G
E
--
R
V
A
A
L
V
A
A
G
V
D
V
V
V
V
D
T
A
H
G
H
S
K
G
V
I
E
R
V
R
W
V
K
-
Q
T
F
--
P
D
V
Q
V
I
G
G
N
I
A
T
A
E
A
A
K
A
L
A
E
A
G
A
D
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
A
G
V
G
V
P
Q
I
S
A
I
A
N
V
A
A
A
L
E
G
------
T
G
V
P
L
I
A
D
G
G
I
R
F
S
G
D
L
A
K
A
M
V
A
G
A
Y
C
V
M
M
G
S
M
F
A
G
T
E
E
A
P
G
----------------------------------------------------------------
G
A
L
S
A
I
V
H
Q
L
M
G
G
L
R
A
A
M
G
Y
T
G
S
A
D
I
Q
Q
----
M
R
T
Q
P
-----
Q
F
V
R
I
T
G
A
---------------------
9
PsiBlast_PDB
84.37
54%
-90
- C2 -
3ZFH
-
?
A:
[2-467]
L
R
I
S
Q
E
A
L
T
F
D
D
V
L
L
I
P
G
Y
S
E
V
L
--
P
K
D
V
S
L
K
T
R
L
T
-------
R
G
I
E
L
N
I
P
L
V
S
A
A
M
D
T
V
T
E
A
R
L
A
I
A
M
A
Q
E
G
G
I
G
I
I
H
K
N
M
G
I
E
Q
Q
A
A
E
V
R
K
V
K
--
K
H
E
T
--------------------------------------------------------------------------------------------------------------------------------------
T
Y
P
L
A
S
K
-
D
E
Q
G
R
L
R
V
G
A
A
V
G
T
--
G
AD
T
--
G
E
--
R
V
A
A
L
V
A
A
G
V
D
V
V
V
V
D
T
A
H
G
H
S
K
G
V
I
E
R
V
R
W
V
K
-
Q
T
F
--
P
D
V
Q
V
I
G
G
N
I
A
T
A
E
A
A
K
A
L
A
E
A
G
A
D
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
A
G
V
G
V
P
Q
I
S
A
I
A
N
V
A
A
A
L
E
G
------
T
G
V
P
L
I
A
D
G
G
I
R
F
S
G
D
L
A
K
A
M
V
A
G
A
Y
C
V
M
M
G
S
M
F
A
G
T
E
E
A
P
----------------------------------------------------------------
K
G
A
L
S
A
I
V
H
Q
L
M
G
G
L
R
A
A
M
G
Y
T
G
S
A
D
I
Q
Q
----
M
R
T
Q
P
-----
Q
F
V
R
I
T
G
A
---------------------
4
PsiBlast_PDB
83.72
57%
-91
- C2 -
3USB
4
?
A:
[29-493]
-
K
F
V
K
E
G
L
T
F
D
D
V
L
L
V
P
A
K
S
D
V
L
--
P
R
E
V
S
V
K
T
V
L
S
-------
E
S
L
Q
L
N
I
P
L
I
S
A
G
M
D
T
V
T
E
A
D
M
A
I
A
M
A
R
Q
G
G
L
G
I
I
H
K
N
M
S
I
E
Q
Q
A
E
Q
V
D
K
V
K
--
R
S
E
S
G
V
I
S
D
P
F
F
L
T
P
E
H
Q
V
Y
D
A
E
H
L
M
G
K
Y
R
I
S
G
V
P
V
V
N
NL
D
--
E
R
K
--
L
V
G
I
I
T
N
R
D
M
R
F
-
I
Q
D
Y
S
I
K
I
S
D
V
M
T
-
K
E
Q
-
L
I
T
A
P
V
G
T
T
L
S
E
A
E
K
I
L
Q
K
Y
K
I
E
K
L
P
L
V
D
N
N
G
V
L
Q
G
L
I
T
------------
I
K
D
I
E
K
V
I
E
F
P
N
S
A
K
-
D
K
Q
G
R
L
L
V
G
A
A
V
G
V
TA
D
--
A
--
M
T
--
R
I
D
A
L
V
K
A
S
V
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
P
--
S
-
L
N
I
I
A
G
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
P
Q
L
T
A
V
Y
D
C
A
T
E
A
R
K
------
H
G
I
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
E
I
Y
Q
G
R
Q
F
K
V
------------------------------------------------
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
E
F
----
L
R
E
N
A
-----
Q
F
I
R
M
S
G
A
G
L
L
------------------
3
PsiBlast_PDB
83.68
59%
-87
- C2 -
3TSD
1
?
A:
[29-497]
-
K
F
V
K
E
G
L
T
F
D
D
V
L
L
V
P
A
K
S
D
V
L
--
P
R
E
V
S
V
K
T
V
L
S
-------
E
S
L
Q
L
N
I
P
L
I
S
A
G
M
D
T
V
T
E
A
D
M
A
I
A
M
A
R
Q
G
G
L
G
I
I
H
K
N
M
S
I
E
Q
Q
A
E
Q
V
D
K
V
K
--
R
S
E
S
G
V
I
S
D
P
F
F
L
T
P
E
H
Q
V
Y
D
A
E
H
L
M
G
K
Y
R
I
S
G
V
P
V
V
N
NL
D
--
E
R
K
--
L
V
G
I
I
T
N
R
D
M
R
F
-
I
Q
D
Y
S
I
K
I
S
D
V
M
--
K
E
Q
-
L
I
T
A
P
V
G
T
T
L
S
E
A
E
K
I
L
Q
K
Y
K
I
E
K
L
P
L
V
D
N
N
G
V
L
Q
G
L
I
T
------------
I
K
D
I
E
K
V
I
E
F
P
N
S
A
K
-
D
K
Q
G
R
L
L
V
G
A
A
V
G
V
--
T
--
A
D
A
M
T
--
R
I
D
A
L
V
K
A
S
V
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
P
--
S
-
L
N
I
I
A
G
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
P
Q
L
T
A
V
Y
D
C
A
T
E
A
R
K
------
H
G
I
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
------
R
Q
F
K
V
Y
R
G
------------------------------------------
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
E
F
----
L
R
E
N
A
-----
Q
F
I
R
M
S
G
A
G
L
L
E
S
H
P
--------------
1
PsiBlast_PDB
83.66
59%
-86
- C2 -
1VRD
-
?
A:
[1-457]
---
M
K
E
A
L
T
F
D
D
V
L
L
V
P
Q
Y
S
E
V
L
--
P
K
D
V
K
I
D
T
R
L
T
-------
R
Q
I
R
I
N
I
P
L
V
S
A
A
M
D
T
V
T
E
A
A
L
A
K
A
L
A
R
E
G
G
I
G
I
I
H
K
N
L
T
P
D
E
Q
A
R
Q
V
S
I
V
K
--
K
T
-----------------------------------------------------------------------------------------------------------------------------------
I
M
S
V
I
E
H
P
N
A
A
R
-
D
E
K
G
R
L
L
V
G
A
A
V
G
T
--
S
PE
T
--
M
E
--
R
V
E
K
L
V
K
A
G
V
D
V
I
V
I
D
T
A
H
G
H
S
R
R
V
I
E
T
L
E
M
I
K
-
A
D
Y
--
P
D
L
P
V
V
A
G
N
V
A
T
P
E
G
T
E
A
L
I
K
A
G
A
D
A
V
K
V
G
V
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
P
Q
L
T
A
V
M
E
C
S
E
V
A
R
K
------
Y
D
V
P
I
I
A
D
G
G
I
R
Y
S
G
D
I
V
K
A
L
A
A
G
A
E
S
V
M
V
G
S
I
F
A
G
T
E
E
A
P
G
E
T
I
L
Y
Q
G
R
K
Y
K
A
Y
R
G
M
G
---------------------------------------
I
E
G
M
V
P
Y
K
G
T
V
K
D
V
V
H
Q
L
V
G
G
L
R
S
G
M
G
Y
I
G
A
R
T
I
K
E
----
L
Q
E
K
A
-----
V
F
V
K
I
T
-----------------------
109
HHSearch
83.35
59%
-87
- C2 -
1VRD
-
?
A:
[1-457]
---
M
K
E
A
L
T
F
D
D
V
L
L
V
P
Q
Y
S
E
V
L
--
P
K
D
V
K
I
D
T
R
L
T
-------
R
Q
I
R
I
N
I
P
L
V
S
A
A
M
D
T
V
T
E
A
A
L
A
K
A
L
A
R
E
G
G
I
G
I
I
H
K
N
L
T
P
D
E
Q
A
R
Q
V
S
I
V
K
--
K
T
-----------------------------------------------------------------------------------------------------------------------------------
I
M
S
V
I
E
H
P
N
A
A
R
-
D
E
K
G
R
L
L
V
G
A
A
V
G
T
--
S
PE
T
--
M
E
--
R
V
E
K
L
V
K
A
G
V
D
V
I
V
I
D
T
A
H
G
H
S
R
R
V
I
E
T
L
E
M
I
K
-
A
D
Y
P
-
D
-
L
P
V
V
A
G
N
V
A
T
P
E
G
T
E
A
L
I
K
A
G
A
D
A
V
K
V
G
V
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
P
Q
L
T
A
V
M
E
C
S
E
V
A
R
K
------
Y
D
V
P
I
I
A
D
G
G
I
R
Y
S
G
D
I
V
K
A
L
A
A
G
A
E
S
V
M
V
G
S
I
F
A
G
T
E
E
A
P
G
E
T
I
L
Y
Q
G
R
K
Y
K
A
Y
R
G
M
G
---------------------------------------
I
E
G
M
V
P
Y
K
G
T
V
K
D
V
V
H
Q
L
V
G
G
L
R
S
G
M
G
Y
I
G
A
R
T
I
K
E
----
L
Q
E
K
A
-----
V
F
V
K
I
T
-----------------------
7
PsiBlast_PDB
83.22
54%
-92
- C2 -
4AVF
-
?
A:
[2-467]
L
R
I
S
Q
E
A
L
T
F
D
D
V
L
L
I
P
G
Y
S
E
V
L
--
P
K
D
V
S
L
K
T
R
L
T
-------
R
G
I
E
L
N
I
P
L
V
S
A
A
M
D
T
V
T
E
A
R
L
A
I
A
M
A
Q
E
G
G
I
G
I
I
H
K
N
M
G
I
E
Q
Q
A
A
E
V
R
K
V
K
--
K
H
E
T
---------------------------------------------------------------------------------------------------------------------------------------
Y
P
L
A
S
K
-
D
E
Q
G
R
L
R
V
G
A
A
V
G
T
--
G
AD
T
--
G
E
--
R
V
A
A
L
V
A
A
G
V
D
V
V
V
V
D
T
A
H
G
H
S
K
G
V
I
E
R
V
R
W
V
K
-
Q
T
F
--
P
D
V
Q
V
I
G
G
N
I
A
T
A
E
A
A
K
A
L
A
E
A
G
A
D
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
A
G
V
G
V
P
Q
I
S
A
I
A
N
V
A
A
A
L
E
G
------
T
G
V
P
L
I
A
D
G
G
I
R
F
S
G
D
L
A
K
A
M
V
A
G
A
Y
C
V
M
M
G
S
M
F
A
G
T
E
E
A
P
G
E
I
E
L
F
Q
G
R
S
Y
K
S
------------------------------------------------
V
P
Y
K
G
A
L
S
A
I
V
H
Q
L
M
G
G
L
R
A
A
M
G
Y
T
G
S
A
D
I
Q
Q
----
M
R
T
Q
P
-----
Q
F
V
R
I
T
G
A
---------------------
108
HHSearch
80.77
49%
-84
- C2 -
2CU0
1
IMDH_PYRHO
A:
[10-480]
--
K
A
I
K
G
Y
T
F
D
D
V
L
L
I
P
Q
A
T
E
V
E
--
P
K
D
V
D
V
S
T
R
I
T
-------
P
N
V
K
L
N
I
P
I
L
S
A
A
M
D
T
V
T
E
W
E
M
A
V
A
M
A
R
E
G
G
L
G
V
I
H
R
N
M
G
I
E
E
Q
V
E
Q
V
K
R
V
K
--
R
A
E
---------------------------------------------------------------------------------------------------------------------------------------
K
Y
K
N
A
V
R
-
D
E
N
G
E
L
L
V
A
A
A
V
S
P
--
F
--
D
--
I
K
--
R
A
I
E
L
D
K
A
G
V
D
V
I
V
V
D
T
A
H
A
H
N
L
K
A
I
K
S
M
K
E
M
R
-
Q
K
V
--
D
-
A
D
F
I
V
G
N
I
A
N
P
K
A
V
D
D
L
--
T
F
A
D
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
A
G
V
G
V
P
Q
I
T
A
V
A
M
V
A
D
R
A
Q
E
------
Y
G
L
Y
V
I
A
D
G
G
I
R
Y
S
G
D
I
V
K
A
I
A
A
G
A
D
A
V
M
L
G
N
L
L
A
G
T
K
E
A
P
G
K
E
V
I
I
N
G
R
K
Y
K
Q
Y
R
G
M
G
S
L
G
A
M
---
M
K
------------------Y
M
K
T
R
K
F
V
P
E
G
V
E
G
V
V
P
Y
R
G
T
V
S
E
V
L
Y
Q
L
V
G
G
L
K
A
G
M
G
Y
V
G
A
R
N
I
R
E
----
L
K
E
K
G
-----
E
F
V
I
I
T
H
A
G
I
K
E
S
H
P
H
D
I
I
I
T
N
E
A
P
N
---
11
PsiBlast_PDB
80.34
49%
-84
- C2 -
2CU0
1
IMDH_PYRHO
A:
[13-480]
-----
K
G
Y
T
F
D
D
V
L
L
I
P
Q
A
T
E
V
E
--
P
K
D
V
D
V
S
T
R
I
T
-------
P
N
V
K
L
N
I
P
I
L
S
A
A
M
D
T
V
T
E
W
E
M
A
V
A
M
A
R
E
G
G
L
G
V
I
H
R
N
M
G
I
E
E
Q
V
E
Q
V
K
R
V
K
--
R
A
E
---------------------------------------------------------------------------------------------------------------------------------------
K
Y
K
N
A
V
R
-
D
E
N
G
E
L
L
V
A
A
A
V
S
P
--
F
--
D
--
I
K
--
R
A
I
E
L
D
K
A
G
V
D
V
I
V
V
D
T
A
H
A
H
N
L
K
A
I
K
S
M
K
E
M
R
-
Q
K
V
--
D
-
A
D
F
I
V
G
N
I
A
N
P
K
A
V
D
D
L
T
F
A
--
D
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
A
G
V
G
V
P
Q
I
T
A
V
A
M
V
A
D
R
A
Q
E
------
Y
G
L
Y
V
I
A
D
G
G
I
R
Y
S
G
D
I
V
K
A
I
A
A
G
A
D
A
V
M
L
G
N
L
L
A
G
T
K
E
A
P
G
K
E
V
I
I
N
G
R
K
Y
K
Q
Y
R
G
M
G
S
L
G
A
M
---
M
K
------------------Y
M
K
T
R
K
F
V
P
E
G
V
E
G
V
V
P
Y
R
G
T
V
S
E
V
L
Y
Q
L
V
G
G
L
K
A
G
M
G
Y
V
G
A
R
N
I
R
E
----
L
K
E
K
G
-----
E
F
V
I
I
T
H
A
G
I
K
E
S
H
P
H
D
I
I
I
T
N
E
A
P
N
---
87
PsiBlast_CBE
79.20
40%
-87
- C2 -
4AF0
2
?
A:
[60-537]
-------
L
T
Y
N
D
F
L
V
L
P
G
H
I
N
F
P
--
A
S
D
V
S
L
Q
S
K
A
T
-------
K
N
I
V
L
N
T
P
F
L
S
S
P
M
D
T
V
T
E
D
R
M
A
I
A
L
A
L
H
G
G
L
G
I
I
H
H
N
C
S
A
E
E
Q
A
A
M
V
R
R
V
K
--
K
Y
E
N
---------------------------------------------------------------------------------------------------------------------------------------
Y
P
Y
A
S
K
V
P
E
S
K
Q
L
Y
C
G
A
A
I
G
T
R
P
G
--
D
--
K
D
--
R
L
K
L
L
A
E
A
G
L
D
V
V
V
L
D
S
S
Q
G
N
S
V
Y
Q
I
E
F
I
K
W
I
K
-
Q
T
Y
--
P
K
I
D
V
I
A
G
N
V
V
T
R
E
Q
A
A
Q
L
I
A
A
G
A
D
G
L
R
I
G
M
G
S
G
S
I
C
I
T
Q
E
V
M
A
V
G
R
P
Q
G
T
A
V
Y
A
V
A
E
F
A
S
R
------
F
G
I
P
C
I
A
D
G
G
I
G
N
I
G
H
I
A
K
A
L
A
L
G
A
S
A
V
M
M
G
G
L
L
A
G
T
T
E
S
P
G
E
Y
F
Y
H
E
G
K
R
V
K
V
Y
R
G
M
G
S
I
E
A
M
EHT------GLDNAATA
R
Y
F
S
E
A
-
D
A
V
K
--
V
A
Q
G
V
S
G
D
V
A
D
K
G
S
I
N
K
F
V
P
Y
L
F
T
G
L
Q
H
S
L
Q
D
A
A
I
K
S
V
S
E
----
L
H
S
C
A
R
S
GS
L
R
F
E
L
R
T
A
S
---------------------
20
PsiBlast_PDB
79.15
41%
-88
- C2 -
4AF0
2
?
B:
[60-537]
-------
L
T
Y
N
D
F
L
V
L
P
G
H
I
N
F
P
--
A
S
D
V
S
L
Q
S
K
A
T
-------
K
N
I
V
L
N
T
P
F
L
S
S
P
M
D
T
V
T
E
D
R
M
A
I
A
L
A
L
H
G
G
L
G
I
I
H
H
N
C
S
A
E
E
Q
A
A
M
V
R
R
V
K
--
K
Y
E
N
---------------------------------------------------------------------------------------------------------------------------------------
Y
P
Y
A
S
K
V
P
E
S
K
Q
L
Y
C
G
A
A
I
G
T
RP
G
--
D
--
K
D
--
R
L
K
L
L
A
E
A
G
L
D
V
V
V
L
D
S
S
Q
G
N
S
V
Y
Q
I
E
F
I
K
W
I
K
-
Q
T
Y
--
P
K
I
D
V
I
A
G
N
V
V
T
R
E
Q
A
A
Q
L
I
A
A
G
A
D
G
L
R
I
G
M
G
S
G
S
I
C
I
T
Q
E
V
M
A
V
G
R
P
Q
G
T
A
V
Y
A
V
A
E
F
A
S
R
------
F
G
I
P
C
I
A
D
G
G
I
G
N
I
G
H
I
A
K
A
L
A
L
G
A
S
A
V
M
M
G
G
L
L
A
G
T
T
E
S
P
G
E
Y
F
Y
H
E
G
K
R
V
K
V
Y
R
G
M
G
S
I
E
A
M
EHT------GLDNAATA
R
Y
F
S
E
A
-
D
A
V
K
--
V
A
Q
G
V
S
G
D
V
A
D
K
G
S
I
N
K
F
V
P
Y
L
F
T
G
L
Q
H
S
L
Q
D
A
G
I
K
S
V
S
E
----
L
H
S
C
A
RSGSL
R
F
E
L
R
T
A
S
---------------------
111
HHSearch
78.00
55%
-92
- C2 -
1EEP
1
IMDH_BORBU
A:
[3-390]
N
K
I
T
K
E
A
L
T
F
D
D
V
S
L
I
P
R
K
S
S
V
L
--
P
S
E
V
S
L
K
T
Q
L
T
-------
K
N
I
S
L
N
I
P
F
L
S
S
A
M
D
T
V
T
E
S
Q
M
A
I
A
I
A
K
E
G
G
I
G
I
I
H
K
N
M
S
I
E
A
Q
R
K
E
I
E
K
V
K
--
T
Y
K
---------------------------------------------------------------------------------------------------------------------------------------
D
F
P
N
A
C
K
-
D
L
N
N
K
L
R
V
G
A
A
V
S
I
--
D
ID
T
--
I
E
--
R
V
E
E
L
V
K
A
H
V
D
I
L
V
I
D
S
A
H
G
H
S
T
R
I
I
E
L
I
K
K
I
K
-
T
K
Y
P-
N
-
L
D
L
I
A
G
N
I
V
T
K
E
A
A
L
D
L
I
S
V
G
A
D
C
L
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
A
G
V
G
V
P
Q
I
T
A
I
C
D
V
Y
E
A
C
N
N
------
T
N
I
C
I
I
A
D
G
G
I
R
F
S
G
D
V
V
K
A
I
A
A
G
A
D
S
V
M
I
G
N
L
F
A
G
T
K
E
S
P
S
E
E
I
I
Y
N
G
K
K
F
K
S
-----------------------------------------------
M
V
P
Y
S
G
K
L
K
D
I
L
T
Q
L
K
G
G
L
M
S
G
M
G
Y
L
G
A
A
T
I
S
D
----
L
K
I
N
S
-----
K
F
V
K
I
S
H
S
---------------------
112
HHSearch
77.80
59%
-103
- C2 -
3FFS
-
IMDH_CRYPV
A:
[4-379]
-
K
N
I
G
K
G
L
T
F
E
D
I
L
L
V
P
N
Y
S
E
V
L
--
P
R
E
V
S
L
E
T
K
L
T
-------
K
N
V
S
L
K
I
P
L
I
S
S
A
M
D
T
V
T
E
H
L
M
A
V
G
M
A
R
L
G
G
I
G
I
I
H
K
N
M
D
M
E
S
Q
V
N
E
V
L
K
V
K
--
N
W
I
---------------------------------------------------------------------------------------
A
Y
S
N
E
N
----------
L
D
---------------------------------------
N
K
G
R
L
R
V
G
A
A
I
G
V
--
N
-----
I
E
--
R
A
K
L
L
V
E
A
G
V
D
V
I
V
L
D
S
A
H
G
H
S
L
N
I
I
R
T
L
K
E
I
K
-
S
K
M
--
N
-
I
D
V
I
V
G
N
V
V
T
E
E
A
T
K
E
L
I
E
N
G
A
D
G
I
K
V
G
I
---------
I
V
A
G
V
G
V
P
Q
I
T
A
I
E
K
C
S
S
V
A
S
K
------
F
G
I
P
I
I
A
D
G
G
I
R
Y
S
G
D
I
G
K
A
L
A
V
G
A
S
S
V
M
I
G
S
I
L
A
G
T
E
E
S
P
G
E
K
E
L
I
G
D
T
V
Y
K
Y
-----------------------------------------------
R
V
K
Y
K
G
E
M
E
G
V
V
Y
Q
L
V
G
G
L
R
S
C
M
G
Y
L
G
S
A
S
I
E
E
----
L
W
K
K
S
-----
S
Y
V
E
I
T
T
S
---------------------
90
PsiBlast_CBE
76.12
40%
-84
- C2 -
1NF7
2
IMDH2_HUMAN
B:
[30-506]
-------
L
T
Y
N
D
F
L
I
L
P
G
Y
I
D
F
T
--
A
D
Q
V
D
L
T
S
A
L
T
-------
K
K
I
T
L
K
T
P
L
V
S
S
P
M
D
T
V
T
E
A
G
M
A
I
A
M
A
L
T
G
G
I
G
F
I
H
H
N
C
T
P
E
F
Q
A
N
E
V
R
K
V
K
--
K
Y
E
Q
G
F
I
T
D
P
V
V
L
S
P
K
----------------------------------
G
I
I
S
S
R
D
I
D
F
L--
E
H
D
C
F
L
E
E
I
M
T
-
K
R
E
D
L
V
V
A
P
A
G
I
T
L
K
E
A
N
E
I
L
Q
R
S
K
K
G
K
L
P
I
V
N
E
D
D
E
L
V
A
I
I
A
------------
R
T
-
L
K
K
N
R
D
Y
P
L
A
S
K
-
D
A
K
K
Q
L
L
C
G
A
A
I
G
T
--
H
--
E
--
D
D
KY
R
L
D
L
L
A
Q
A
G
V
D
V
V
V
L
D
S
S
Q
G
N
S
I
F
Q
I
N
M
I
K
Y
I
K
D
K
Y
P
--
N
-
L
Q
V
I
G
G
N
V
V
T
A
A
Q
A
K
N
L
I
D
A
G
V
D
A
L
R
V
G
M
G
S
G
S
I
C
I
T
Q
E
V
L
A
C
G
R
P
Q
A
T
A
V
Y
K
V
S
E
Y
A
R
R
------
F
G
V
P
V
I
A
D
G
G
I
Q
N
V
G
H
I
A
K
A
L
A
L
G
A
S
T
V
M
M
G
S
L
L
A
A
T
T
E
A
P
G
E
Y
F
F
S
D
G
I
R
L
K
K
Y
R
G
M
G
S
L
D
A
M
----------------------------
I
K
V
A
Q
G
V
S
G
A
V
Q
D
K
G
S
I
H
K
F
V
P
Y
L
I
A
G
I
Q
H
S
C
Q
D
I
G
A
K
S
L
T
Q
VRAM
M
Y
S
G
E
L----
K
F
E
K
R
T
S
S
A
Q
V
E
G
G
V
H
S
L
H
S
Y
E
K
R
L
F
---
107
HHSearch
76.06
35%
-79
- C2 -
1ME8
3
IMDH_TRIFO
A:
[7-492]
----
E
P
C
H
T
F
N
E
Y
L
L
I
P
G
L
S
T
V
D
CI
P
S
N
V
N
L
S
T
P
L
V
K
F
Q
KGQQ
S
E
I
N
L
K
I
P
L
V
S
A
I
M
Q
S
V
S
G
E
K
M
A
I
A
L
A
R
E
G
G
I
S
F
I
F
G
S
Q
S
I
E
S
Q
A
A
M
V
H
A
V
K
N
F
K
A
------------------------------------------------------------------------------------------------------------------------------------------
H
N
E
L
V
-
D
S
Q
K
R
Y
L
V
G
A
G
I
N
T
--
R
D-
F
--
R
E
--
R
V
P
A
L
V
E
A
G
A
D
V
L
C
I
D
S
S
D
G
F
S
E
W
Q
K
I
T
I
G
W
I
R
-
E
K
Y
GD
K
-
V
K
V
G
A
G
N
I
V
D
G
E
G
F
R
Y
L
A
D
A
G
A
D
F
I
K
I
G
I
G
G
G
S
I
C
I
T
R
E
Q
K
G
I
G
R
G
Q
A
T
A
V
I
D
V
V
A
E
R
N
K
Y
F
E
ET
G
I
Y
I
P
V
C
S
D
G
G
I
V
Y
D
Y
H
M
T
L
A
L
A
M
G
A
D
F
I
M
L
G
R
Y
F
A
R
F
E
E
S
P
T
R
K
V
T
I
N
G
S
V
M
K
E
Y
W
G
E
G
S
S
R
A
R
---
N
W
---------------------------
E
G
V
D
S
Y
V
P
Y
A
G
K
L
K
D
N
V
E
A
S
L
N
K
V
K
S
T
M
C
N
C
G
A
L
T
I
P
Q
----
L
Q
S
K
A
-----
K
I
T
L
V
S
S
V
S
I
V
E
G
G
A
H
D
V
I
----------
91
PsiBlast_CBE
76.01
40%
-83
- C2 -
1NF7
3
IMDH2_HUMAN
A:
[30-506]
-------
L
T
Y
N
D
F
L
I
L
P
G
Y
I
D
F
T
--
A
D
Q
V
D
L
T
S
A
L
T
-------
K
K
I
T
L
K
T
P
L
V
S
S
P
M
D
T
V
T
E
A
G
M
A
I
A
M
A
L
T
G
G
I
G
F
I
H
H
N
C
T
P
E
F
Q
A
N
E
V
R
K
V
K
--
K
Y
E
Q
G
F
I
T
D
P
V
V
L
S
P
K
----------------------------------
G
I
I
S
S
R
D
I
D
F
L--
E
H
D
C
F
L
E
E
I
M
T
-
K
R
E
D
L
V
V
A
P
A
G
I
T
L
K
E
A
N
E
I
L
Q
R
S
K
K
G
K
L
P
I
V
N
E
D
D
E
L
V
A
I
I
A
------------
R
T
-
L
K
K
N
R
D
Y
P
L
A
S
K
-
D
A
K
K
Q
L
L
C
G
A
A
I
G
T
--
H
--
E
--
D
D
K
Y
R
L
D
L
L
A
Q
A
G
V
D
V
V
V
L
D
S
S
Q
G
N
S
I
F
Q
I
N
M
I
K
Y
I
K
D
K
Y
P
--
N
-
L
Q
V
I
G
G
N
V
V
T
A
A
Q
A
K
N
L
I
D
A
G
V
D
A
L
R
V
G
M
G
S
G
S
I
C
I
T
Q
E
V
L
A
C
G
R
P
Q
A
T
A
V
Y
K
V
S
E
Y
A
R
R
------
F
G
V
P
V
I
A
D
G
G
I
Q
N
V
G
H
I
A
K
A
L
A
L
G
A
S
T
V
M
M
G
S
L
L
A
A
T
T
E
A
P
G
E
Y
F
F
S
D
G
I
R
L
K
K
Y
R
G
M
G
S
L
D
A
M
----------------------------
I
K
V
A
Q
G
V
S
G
A
V
Q
D
K
G
S
I
H
K
F
V
P
Y
L
I
A
G
I
Q
H
S
C
Q
D
I
G
A
K
S
L
T
Q
V
R
A
M
M
Y
S
G
E
L
----
K
F
E
K
R
T
S
S
A
Q
V
E
G
G
V
H
S
L
H
S
Y
E
K
R
L
F
---
89
PsiBlast_CBE
75.02
40%
-91
- C2 -
1NFB
2
IMDH2_HUMAN
A:
[30-498]
-------
L
T
Y
N
D
F
L
I
L
P
G
Y
I
D
F
T
--
A
D
Q
V
D
L
T
S
A
L
T
-------
K
K
I
T
L
K
T
P
L
V
S
S
P
M
D
T
V
T
E
A
G
M
A
I
A
M
A
L
T
G
G
I
G
F
I
H
H
N
C
T
P
E
F
Q
A
N
E
V
R
K
V
K
--
K
Y
E
Q
G
F
I
T
D
P
V
V
L
S
P
-----------------
G
I
P
I
T
D
--
T
--
G
R
M
GS----------------------------------
A
P
A
G
I
T
L
K
E
A
N
E
I
L
Q
R
S
K
K
G
K
L
P
I
V
N
E
D
D
E
-
V
A
I
I
A
------------------
N
R
D
Y
P
L
A
S
K
-
D
A
K
K
Q
L
L
C
G
A
A
I
G
T
--
H
--
E
--
D
D
K
Y
R
L
D
L
L
A
Q
A
G
V
D
V
V
V
L
D
S
S
Q
G
N
S
I
F
Q
I
N
M
I
K
Y
I
K
D
K
Y
P
--
N
-
L
Q
V
I
G
G
N
V
V
T
A
A
Q
A
K
N
L
I
D
A
G
V
D
A
L
R
V
G
M
G
S
G
S
I
C
I
T
Q
E
V
L
A
C
G
R
P
Q
A
T
A
V
Y
K
V
S
E
Y
A
R
R
------
F
G
V
P
V
I
A
D
G
G
I
Q
N
V
G
H
I
A
K
A
L
A
L
G
A
S
T
V
M
M
G
S
L
L
A
A
T
T
E
A
P
G
E
Y
F
F
S
D
G
I
R
L
K
K
Y
R
G
M
----------------------------------------------
D
K
G
S
I
H
K
F
V
P
Y
L
I
A
G
I
Q
H
S
C
Q
D
I
G
A
K
S
L
T
Q
V
R
A
M
M
Y
S
G
E
L
----
K
F
E
K
R
T
S
S
A
Q
-------------------
88
PsiBlast_CBE
74.74
40%
-91
- C2 -
1NFB
2
IMDH2_HUMAN
B:
[30-498]
-------
L
T
Y
N
D
F
L
I
L
P
G
Y
I
D
F
T
--
A
D
Q
V
D
L
T
S
A
L
T
-------
K
K
I
T
L
K
T
P
L
V
S
S
P
M
D
T
V
T
E
A
G
M
A
I
A
M
A
L
T
G
G
I
G
F
I
H
H
N
C
T
P
E
F
Q
A
N
E
V
R
K
V
K
--
K
Y
E
Q
G
F
I
T
D
P
V
V
L
S
P
-----------------
G
I
P
I
T
D
--
T
--
G
R
M
GS----------------------------------
A
P
A
G
I
T
L
K
E
A
N
E
I
L
Q
R
S
K
K
G
K
L
P
I
V
N
E
D
D
E
-
V
A
I
I
A
------------------
N
R
D
Y
P
L
A
S
K
-
D
A
K
K
Q
L
L
C
G
A
A
I
G
T
--
H
--
E
--
D
D
KY
R
L
D
L
L
A
Q
A
G
V
D
V
V
V
L
D
S
S
Q
G
N
S
I
F
Q
I
N
M
I
K
Y
I
K
D
K
Y
P
--
N
-
L
Q
V
I
G
G
N
V
V
T
A
A
Q
A
K
N
L
I
D
A
G
V
D
A
L
R
V
G
M
G
S
G
S
I
C
I
T
Q
E
V
L
A
C
G
R
P
Q
A
T
A
V
Y
K
V
S
E
Y
A
R
R
------
F
G
V
P
V
I
A
D
G
G
I
Q
N
V
G
H
I
A
K
A
L
A
L
G
A
S
T
V
M
M
G
S
L
L
A
A
T
T
E
A
P
G
E
Y
F
F
S
D
G
I
R
L
K
K
Y
R
G
M
----------------------------------------------
D
K
G
S
I
H
K
F
V
P
Y
L
I
A
G
I
Q
H
S
C
Q
D
I
G
A
K
S
L
T
Q
VRAM
M
Y
S
G
E
L----
K
F
E
K
R
T
S
S
A
Q
-------------------
26
PsiBlast_CBE
73.17
60%
-81
- C2 -
4MZ1
7
?
B:
[28-380]
--------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
V
K
I
-
H
T
K
L
T
K
---
N
I
T
L
-
N
M
P
-
L
I
S
A
A
M
D
T
V
T
E
H
R
A
A
I
M
M
A
-
R
L
G
G
L
G
V
I
H
K
N
M
D
I
A
S
Q
V
R
E
V
K
R
V
K
K
S-----------
K
E
Y
P
D
A
N
K
-
D
N
F
G
R
L
R
V
G
A
A
I
G
V
--
G
--
Q
--
M
D
--
R
V
D
A
L
V
E
A
G
V
D
V
V
V
L
D
S
A
H
G
H
S
K
G
I
I
D
T
V
K
A
I
K
A
K
Y
P
--
N
-
L
D
L
I
A
G
N
I
A
T
A
A
A
A
K
A
L
C
E
A
G
V
D
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
S
G
V
G
V
P
Q
I
S
A
I
D
E
C
V
E
E
A
N
K
------
F
G
V
P
V
I
A
D
G
G
I
K
Y
S
G
D
I
A
K
A
L
A
V
G
A
S
S
V
M
I
G
S
L
L
A
G
T
D
E
S
P
G
E
L
F
T
Y
Q
G
R
Q
Y
K
S
Y
R
G
M
G
S
L
G
A
M
---
Q
K
------------------------
L
V
P
E
G
I
E
G
R
V
P
Y
V
G
S
I
R
S
V
V
H
Q
L
L
G
G
L
R
S
S
M
G
Y
V
G
A
K
D
I
E
D
----
F
Q
K
R
A
-----
E
F
V
E
I
T
T
A
G
L
K
E
S
H
V
H
D
V
T
I
T
H
E
A
P
N
Y
K
V
13
PsiBlast_PDB
72.73
60%
-77
- C2 -
4MZ1
7
?
A:
[28-380]
--------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
V
K
I
-
H
T
K
L
T
K
---
N
I
T
L
-
N
M
P
-
L
I
S
A
A
M
D
T
V
T
E
H
R
A
A
I
M
M
A
-
R
L
G
G
L
G
V
I
H
K
N
M
D
I
A
S
Q
V
R
E
V
K
R
V
K
K
S-----------
K
E
Y
P
D
A
N
K
-
D
N
F
G
R
L
R
V
G
A
A
I
G
V
--
G
--
Q
--
M
D
--
R
V
D
A
L
V
E
A
G
V
D
V
V
V
L
D
S
A
H
G
H
S
K
G
I
I
D
T
V
K
A
I
K
A
K
Y
P
--
N
-
L
D
L
I
A
G
N
I
A
T
A
A
A
A
K
A
L
C
E
A
G
V
D
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
S
G
V
G
V
P
Q
I
S
A
I
D
E
C
V
E
E
A
N
K
------
F
G
V
P
V
I
A
D
G
G
I
K
Y
S
G
D
I
A
K
A
L
A
V
G
A
S
S
V
M
I
G
S
L
L
A
G
T
D
E
S
P
G
E
L
F
T
Y
Q
G
R
Q
Y
K
S
Y
R
G
M
G
S
L
G
A
M
---
Q
K
------------------------
L
V
P
E
G
I
E
G
R
V
P
Y
V
G
S
I
R
S
V
V
H
Q
L
L
G
G
L
R
S
S
M
G
Y
V
G
A
K
D
I
E
D
----
F
Q
K
R
A
-----
E
F
V
E
I
T
T
A
G
L
K
E
S
H
V
H
D
V
T
I
T
H
E
A
P
N
Y
K
V
25
PsiBlast_CBE
72.72
60%
-79
- C2 -
4MZ1
7
?
C:
[28-380]
--------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
V
K
I
-
H
T
K
L
T
K
---
N
I
T
L
-
N
M
P
-
L
I
S
A
A
M
D
T
V
T
E
H
R
A
A
I
M
M
A
-
R
L
G
G
L
G
V
I
H
K
N
M
D
I
A
S
Q
V
R
EVKRVKKSESGG
I
K
---
K
R
K
E
Y
P
D
A
N
K
-
D
N
F
G
R
L
R
V
G
A
A
I
G
V
--
G
--
Q
--
M
D
--
R
V
D
A
L
V
E
A
G
V
D
V
V
V
L
D
S
A
H
G
H
S
K
G
I
I
D
T
V
K
A
I
K
A
K
Y
P
--
N
-
L
D
L
I
A
G
N
I
A
T
A
A
A
A
K
A
L
C
E
A
G
V
D
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
S
G
V
G
V
P
Q
I
S
A
I
D
E
C
V
E
E
A
N
K
------
F
G
V
P
V
I
A
D
G
G
I
K
Y
S
G
D
I
A
K
A
L
A
V
G
A
S
S
V
M
I
G
S
L
L
A
G
T
D
E
S
P
G
E
L
F
T
Y
Q
G
R
Q
Y
K
S
Y
R
G
M
G
S
L
G
A
M
---
Q
K
------------------------
L
V
P
E
G
I
E
G
R
V
P
Y
V
G
S
I
R
S
V
V
H
Q
L
L
G
G
L
R
S
S
M
G
Y
V
G
A
K
D
I
E
D
----
F
Q
K
R
A
-----
E
F
V
E
I
T
T
A
G
L
K
E
S
H
V
H
D
V
T
I
T
H
E
A
P
N
Y
K
V
14
PsiBlast_PDB
72.07
60%
-76
- C2 -
4R7J
8
?
A:
[28-380]
--------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
V
K
I
-
H
T
K
L
T
K
---
N
I
T
L
-
N
M
P
-
L
I
S
A
A
M
D
T
V
T
E
H
R
A
A
I
M
M
A
-
R
L
G
G
L
G
V
I
H
K
N
M
D
I
A
S
Q
V
R
E
V
K
R
V
K
K
SE-------
K
K
R
K
E
Y
P
D
A
N
K
-
D
N
F
G
R
L
R
V
G
A
A
I
G
V
--
G
--
Q
--
M
D
--
R
V
D
A
L
V
E
A
G
V
D
V
V
V
L
D
S
A
H
G
H
S
K
G
I
I
D
T
V
K
A
I
K
A
K
Y
P
--
N
-
L
D
L
I
A
G
N
I
A
T
A
A
A
A
K
A
L
C
E
A
G
V
D
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
S
G
V
G
V
P
Q
I
S
A
I
D
E
C
V
E
E
A
N
K
------
F
G
V
P
V
I
A
D
G
G
I
K
Y
S
G
D
I
A
K
A
L
A
V
G
A
S
S
V
M
I
G
S
L
L
A
G
T
D
E
S
P
G
E
L
F
T
Y
Q
G
R
Q
Y
K
S
Y
R
G
M
G
S
L
G
A
M
---
Q
K
------------------------
L
V
P
E
G
I
E
G
R
V
P
Y
V
G
S
I
R
S
V
V
H
Q
L
L
G
G
L
R
S
S
M
G
Y
V
G
A
K
D
I
E
D
----
F
Q
K
R
A
-----
E
F
V
E
I
T
T
A
G
L
K
E
S
H
V
H
D
V
T
I
T
H
E
A
P
N
Y
K
-
84
PsiBlast_CBE
66.52
59%
-94
- C2 -
4IX2
2
?
A:
[95-363]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
L
R
V
G
A
A
V
G
A
AP
G
--
N
--
E
E
--
R
V
K
A
L
V
E
A
G
V
D
V
L
L
I
D
S
S
H
G
H
S
E
G
V
L
Q
R
I
R
E
T
R
-
A
A
Y
--
P
H
L
E
I
I
G
G
N
V
A
T
A
E
G
A
R
A
L
I
E
A
G
V
S
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
T
G
V
G
V
P
Q
I
T
A
I
A
D
A
A
G
V
A
N
E
------
Y
G
I
P
V
I
A
D
G
G
I
R
F
S
G
D
I
S
K
A
I
A
A
G
A
S
C
V
M
V
G
S
M
F
A
G
T
E
E
A
P
G
E
V
I
L
Y
Q
G
R
S
Y
K
A
Y
R
G
M
-------------------------------------
P
E
G
I
E
G
R
I
A
Y
K
G
H
L
K
E
I
I
H
Q
Q
M
G
G
L
R
S
C
M
G
L
T
G
S
A
T
V
E
D
----
L
R
T
K
A
-----
Q
F
V
R
I
S
G
A
G
M
K
E
S
H
V
H
D
V
Q
I
T
K
E
A
P
N
Y
R
-
82
PsiBlast_CBE
66.31
59%
-97
- C2 -
4IX2
3
?
C:
[95-363]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
L
R
V
G
A
A
V
G
A
AP
G
--
N
--
E
E
--
R
V
K
A
L
V
E
A
G
V
D
V
L
L
I
D
S
S
H
G
H
S
E
G
V
L
Q
R
I
R
E
T
R
-
A
A
Y
--
P
H
L
E
I
I
G
G
N
V
A
T
A
E
G
A
R
A
L
I
E
A
G
V
S
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
T
G
V
G
V
P
Q
I
T
A
I
A
D
A
A
G
V
A
N
E
------
Y
G
I
P
V
I
A
D
G
G
I
R
F
S
G
D
I
S
K
A
I
A
A
G
A
S
C
V
M
V
G
S
M
F
A
G
T
E
E
A
P
G
E
V
I
L
Y
Q
G
R
S
Y
K
A
Y
R
G
M
-------------------------------------
P
E
G
I
E
G
R
I
A
Y
K
G
H
L
K
E
I
I
H
Q
Q
M
G
G
L
R
S
C
M
G
L
T
G
S
A
T
V
E
D
----
L
R
T
K
A
-----
Q
F
V
R
I
S
G
A
G
M
K
E
S
H
V
H
D
V
Q
I
T
K
E
A
P
N
Y
--
81
PsiBlast_CBE
65.92
59%
-98
- C2 -
4IX2
3
?
D:
[95-363]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
L
R
V
G
A
A
V
G
A
AP
G
--
N
--
E
E
--
R
V
K
A
L
V
E
A
G
V
D
V
L
L
I
D
S
S
H
G
H
S
E
G
V
L
Q
R
I
R
E
T
R
-
A
A
Y
--
P
H
L
E
I
I
G
G
N
V
A
T
A
E
G
A
R
A
L
I
E
A
G
V
S
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
T
G
V
G
V
P
Q
I
T
A
I
A
D
A
A
G
V
A
N
E
------
Y
G
I
P
V
I
A
D
G
G
I
R
F
S
G
D
I
S
K
A
I
A
A
G
A
S
C
V
M
V
G
S
M
F
A
G
T
E
E
A
P
G
E
V
I
L
Y
Q
G
R
S
Y
K
A
Y
R
G
M
-------------------------------------
P
E
G
I
E
G
R
I
A
Y
K
G
H
L
K
E
I
I
H
Q
Q
M
G
G
L
R
S
C
M
G
L
T
G
S
A
T
V
E
D
----
L
R
T
K
A
-----
Q
F
V
R
I
S
G
A
G
M
K
E
S
H
V
H
D
V
Q
I
T
K
E
A
P
N
Y
--
86
PsiBlast_CBE
65.90
59%
-96
- C2 -
4FO4
3
?
A:
[95-363]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
L
R
V
G
A
A
V
G
A
AP
G
--
N
--
E
E
--
R
V
K
A
L
V
E
A
G
V
D
V
L
L
I
D
S
S
H
G
H
S
E
G
V
L
Q
R
I
R
E
T
R
-
A
A
Y
--
P
H
L
E
I
I
G
G
N
V
A
T
A
E
G
A
R
A
L
I
E
A
G
V
S
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
T
G
V
G
V
P
Q
I
T
A
I
A
D
A
A
G
V
A
N
E
------
Y
G
I
P
V
I
A
D
G
G
I
R
F
S
G
D
I
S
K
A
I
A
A
G
A
S
C
V
M
V
G
S
M
F
A
G
T
E
E
A
P
G
E
V
I
L
Y
Q
G
R
S
Y
K
A
Y
R
G
M
G
S
L
G
A
M
---
S
------------------------
K
L
V
P
E
G
I
E
G
R
I
A
Y
K
G
H
L
K
E
I
I
H
Q
Q
M
G
G
L
R
S
C
M
G
L
T
G
S
A
T
V
E
D
----
L
R
T
K
A
-----
Q
F
V
R
I
S
G
A
G
M
K
E
S
H
V
H
D
V
Q
I
T
K
E
A
P
N
Y
R
L
77
PsiBlast_CBE
65.66
59%
-94
- C2 -
4X3Z
4
?
A:
[95-363]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
L
R
V
G
A
A
V
G
A
AP
G
--
N
--
E
E
--
R
V
K
A
L
V
E
A
G
V
D
V
L
L
I
D
S
S
H
G
H
S
E
G
V
L
Q
R
I
R
E
T
R
-
A
A
Y
--
P
H
L
E
I
I
G
G
N
V
A
T
A
E
G
A
R
A
L
I
E
A
G
V
S
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
T
G
V
G
V
P
Q
I
T
A
I
A
D
A
A
G
V
A
N
E
------
Y
G
I
P
V
I
A
D
G
G
I
R
F
S
G
D
I
S
K
A
I
A
A
G
A
S
C
V
M
V
G
S
M
F
A
G
T
E
E
A
P
G
E
V
I
L
Y
Q
G
R
S
Y
K
A
Y
R
G
M
G
S
L
G
A
M
---
S
-------------------------
L
V
P
E
G
I
E
G
R
I
A
Y
K
G
H
L
K
E
I
I
H
Q
Q
M
G
G
L
R
S
C
M
G
L
T
G
S
A
T
V
E
D
----
L
R
T
K
A
-----
Q
F
V
R
I
S
G
A
G
M
K
E
S
H
V
H
D
V
Q
I
T
K
E
A
P
N
Y
--
85
PsiBlast_CBE
65.52
59%
-93
- C2 -
4FO4
3
?
B:
[95-363]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
L
R
V
G
A
A
V
G
A
AP
G
--
N
--
E
E
--
R
V
K
A
L
V
E
A
G
V
D
V
L
L
I
D
S
S
H
G
H
S
E
G
V
L
Q
R
I
R
E
T
R
-
A
A
Y
--
P
H
L
E
I
I
G
G
N
V
A
T
A
E
G
A
R
A
L
I
E
A
G
V
S
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
T
G
V
G
V
P
Q
I
T
A
I
A
D
A
A
G
V
A
N
E
------
Y
G
I
P
V
I
A
D
G
G
I
R
F
S
G
D
I
S
K
A
I
A
A
G
A
S
C
V
M
V
G
S
M
F
A
G
T
E
E
A
P
G
E
V
I
L
Y
Q
G
R
S
Y
K
A
Y
R
G
M
G
S
L
G
A
M
---
S
------------------------
K
L
V
P
E
G
I
E
G
R
I
A
Y
K
G
H
L
K
E
I
I
H
Q
Q
M
G
G
L
R
S
C
M
G
L
T
G
S
A
T
V
E
D
----
L
R
T
K
A
-----
Q
F
V
R
I
S
G
A
G
M
K
E
S
H
V
H
D
V
Q
I
T
K
E
A
P
N
Y
R
-
79
PsiBlast_CBE
65.51
59%
-91
- C2 -
4QNE
3
?
B:
[95-363]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
L
R
V
G
A
A
V
G
A
AP
G
--
N
--
E
E
--
R
V
K
A
L
V
E
A
G
V
D
V
L
L
I
D
S
S
H
G
H
S
E
G
V
L
Q
R
I
R
E
T
R
-
A
A
Y
--
P
H
L
E
I
I
G
G
N
V
A
T
A
E
G
A
R
A
L
I
E
A
G
V
S
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
T
G
V
G
V
P
Q
I
T
A
I
A
D
A
A
G
V
A
N
E
------
Y
G
I
P
V
I
A
D
G
G
I
R
F
S
G
D
I
S
K
A
I
A
A
G
A
S
C
V
M
V
G
S
M
F
A
G
T
E
E
A
P
G
E
V
I
L
Y
Q
G
R
S
Y
K
A
Y
R
G
M
G
S
L
G
A
M
---
S
-------------------------
L
V
P
E
G
I
E
G
R
I
A
Y
K
G
H
L
K
E
I
I
H
Q
Q
M
G
G
L
R
S
C
M
G
L
T
G
S
A
T
V
E
D
----
L
R
T
K
A
-----
Q
F
V
R
I
S
G
A
G
M
K
E
S
H
V
H
D
V
Q
I
T
K
E
A
P
N
Y
R
L
83
PsiBlast_CBE
65.49
59%
-91
- C2 -
4IX2
2
?
B:
[95-363]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
L
R
V
G
A
A
V
G
A
AP
G
--
N
--
E
E
--
R
V
K
A
L
V
E
A
G
V
D
V
L
L
I
D
S
S
H
G
H
S
E
G
V
L
Q
R
I
R
E
T
R
-
A
A
Y
--
P
H
L
E
I
I
G
G
N
V
A
T
A
E
G
A
R
A
L
I
E
A
G
V
S
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
T
G
V
G
V
P
Q
I
T
A
I
A
D
A
A
G
V
A
N
E
------
Y
G
I
P
V
I
A
D
G
G
I
R
F
S
G
D
I
S
K
A
I
A
A
G
A
S
C
V
M
V
G
S
M
F
A
G
T
E
E
A
P
G
E
V
I
L
Y
Q
G
R
S
Y
K
A
Y
R
G
M
-------------------------------------
P
E
G
I
E
G
R
I
A
Y
K
G
H
L
K
E
I
I
H
Q
Q
M
G
G
L
R
S
C
M
G
L
T
G
S
A
T
V
E
D
----
L
R
T
K
A
-----
Q
F
V
R
I
S
G
A
G
M
K
E
S
H
V
H
D
V
Q
I
T
K
E
A
P
N
Y
R
-
76
PsiBlast_CBE
65.33
59%
-93
- C2 -
4X3Z
3
?
B:
[95-363]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
L
R
V
G
A
A
V
G
A
AP
G
--
N
--
E
E
--
R
V
K
A
L
V
E
A
G
V
D
V
L
L
I
D
S
S
H
G
H
S
E
G
V
L
Q
R
I
R
E
T
R
-
A
A
Y
--
P
H
L
E
I
I
G
G
N
V
A
T
A
E
G
A
R
A
L
I
E
A
G
V
S
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
T
G
V
G
V
P
Q
I
T
A
I
A
D
A
A
G
V
A
N
E
------
Y
G
I
P
V
I
A
D
G
G
I
R
F
S
G
D
I
S
K
A
I
A
A
G
A
S
C
V
M
V
G
S
M
F
A
G
T
E
E
A
P
G
E
V
I
L
Y
Q
G
R
S
Y
K
A
Y
R
G
M
G
S
L
G
A
M
---
S
------------------------
K
L
V
P
E
G
I
E
G
R
I
A
Y
K
G
H
L
K
E
I
I
H
Q
Q
M
G
G
L
R
S
C
M
G
L
T
G
S
A
T
V
E
D
----
L
R
T
K
A
-----
Q
F
V
R
I
S
G
A
G
M
K
E
S
H
V
H
D
V
Q
I
T
K
E
A
P
N
Y
R
L
80
PsiBlast_CBE
65.09
59%
-89
- C2 -
4QNE
3
?
A:
[95-363]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
L
R
V
G
A
A
V
G
A
AP
G
--
N
--
E
E
--
R
V
K
A
L
V
E
A
G
V
D
V
L
L
I
D
S
S
H
G
H
S
E
G
V
L
Q
R
I
R
E
T
R
-
A
A
Y
--
P
H
L
E
I
I
G
G
N
V
A
T
A
E
G
A
R
A
L
I
E
A
G
V
S
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
T
G
V
G
V
P
Q
I
T
A
I
A
D
A
A
G
V
A
N
E
------
Y
G
I
P
V
I
A
D
G
G
I
R
F
S
G
D
I
S
K
A
I
A
A
G
A
S
C
V
M
V
G
S
M
F
A
G
T
E
E
A
P
G
E
V
I
L
Y
Q
G
R
S
Y
K
A
Y
R
G
M
G
S
L
G
A
M
---
S
-------------------------
L
V
P
E
G
I
E
G
R
I
A
Y
K
G
H
L
K
E
I
I
H
Q
Q
M
G
G
L
R
S
C
M
G
L
T
G
S
A
T
V
E
D
----
L
R
T
K
A
-----
Q
F
V
R
I
S
G
A
G
M
K
E
S
H
V
H
D
V
Q
I
T
K
E
A
P
N
Y
R
L
54
PsiBlast_CBE
64.82
61%
-97
- C2 -
4MYA
3
?
B:
[116-382]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
L
L
V
G
A
A
V
G
V
--
T
--
A
D
A
M
T
--
R
I
D
A
L
V
K
A
S
V
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
P
--
S
-
L
N
I
I
A
G
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
P
Q
L
T
A
V
Y
D
C
A
T
E
A
R
K
------
H
G
I
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
E
I
Y
Q
G
R
Q
F
K
V
Y
R
G
M
G
S
V
G
A
M
---
E
K
-----------------------
K
L
V
P
E
G
I
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
E
F
----
L
R
E
N
A
-----
Q
F
I
R
M
S
G
A
G
L
L
E
S
H
P
H
H
V
Q
I
T
K
E
A
P
N
Y
--
55
PsiBlast_CBE
64.58
61%
-94
- C2 -
4MYA
4
?
A:
[116-382]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
L
L
V
G
A
A
V
G
V
--
T
--
A
D
A
M
T
--
R
I
D
A
L
V
K
A
S
V
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
P
--
S
-
L
N
I
I
A
G
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
P
Q
L
T
A
V
Y
D
C
A
T
E
A
R
K
------
H
G
I
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
E
I
Y
Q
G
R
Q
F
K
V
Y
R
G
M
G
S
V
G
A
M
---
E
K
----------------------
K
K
L
V
P
E
G
I
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
E
F
----
L
R
E
N
A
-----
Q
F
I
R
M
S
G
A
G
L
L
E
S
H
P
H
H
V
Q
I
T
K
E
A
P
N
Y
--
78
PsiBlast_CBE
64.25
59%
-105
- C2 -
4QQ3
3
?
A:
[95-344]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
L
R
V
G
A
A
V
G
A
AP
G
--
N
--
E
E
--
R
V
K
A
L
V
E
A
G
V
D
V
L
L
I
D
S
S
H
G
H
S
E
G
V
L
Q
R
I
R
E
T
R
-
A
A
Y
--
P
H
L
E
I
I
G
G
N
V
A
T
A
E
G
A
R
A
L
I
E
A
G
V
S
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
T
G
V
G
V
P
Q
I
T
A
I
A
D
A
A
G
V
A
N
E
------
Y
G
I
P
V
I
A
D
G
G
I
R
F
S
G
D
I
S
K
A
I
A
A
G
A
S
C
V
M
V
G
S
M
F
A
G
T
E
E
A
P
-------
G
R
S
Y
K
A
Y
R
G
M
G
------------------------------------------
R
I
A
Y
K
G
H
L
K
E
I
I
H
Q
Q
M
G
G
L
R
S
C
M
G
L
T
G
S
A
T
V
E
D
----
L
R
T
K
A
-----
Q
F
V
R
I
S
G
A
---------------------
44
PsiBlast_CBE
64.21
61%
-97
- C2 -
4QM1
3
?
B:
[116-382]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
L
L
V
G
A
A
V
G
V
--
T
--
A
D
A
M
T
--
R
I
D
A
L
V
K
A
S
V
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
P
--
S
-
L
N
I
I
A
G
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
P
Q
L
T
A
V
Y
D
C
A
T
E
A
R
K
------
H
G
I
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
E
I
Y
Q
G
R
Q
F
K
V
Y
R
G
M
G
S
V
G
A
M
---
E
K
-----------------------
K
L
V
P
E
G
I
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
E
F
----
L
R
E
N
A
-----
Q
F
I
R
M
S
G
A
G
L
L
-----
H
V
Q
I
T
K
E
A
P
N
Y
S
-
45
PsiBlast_CBE
63.73
61%
-96
- C2 -
4QM1
3
?
A:
[116-376]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
L
L
V
G
A
A
V
G
V
--
T
--
A
D
A
M
T
--
R
I
D
A
L
V
K
A
S
V
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
P
--
S
-
L
N
I
I
A
G
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
P
Q
L
T
A
V
Y
D
C
A
T
E
A
R
K
------
H
G
I
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
E
I
Y
Q
G
R
Q
F
K
V
Y
R
G
M
G
S
V
G
A
M
---
E
K
-------------------------
V
P
E
G
I
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
E
F
----
L
R
E
N
A
-----
Q
F
I
R
M
S
G
A
G
L
L
------
V
Q
I
T
--------
66
PsiBlast_CBE
63.01
61%
-97
- C2 -
4MY8
7
?
B:
[116-366]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
L
L
V
G
A
A
V
G
V
--
T
--
A
DA
M
T
--
R
I
D
A
L
V
K
A
S
V
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
P
--
S
-
L
N
I
I
A
G
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
P
Q
L
T
A
V
Y
D
C
A
T
E
A
R
K
------
H
G
I
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
E
I
Y
Q
G
R
Q
F
K
V
Y
R
G
M
G
S
V
G
A
M
---
E
K
------------------------
L
V
P
E
G
I
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
E
F
----
L
R
E
N
A
-----
Q
F
I
R
M
S
G
A
G
L
L
------------------
42
PsiBlast_CBE
62.86
61%
-96
- C2 -
4QM1
3
?
D:
[116-376]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
L
L
V
G
A
A
V
G
V
--
T
--
A
DA
M
T
--
R
I
D
A
L
V
K
A
S
V
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
P
--
S
-
L
N
I
I
A
G
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
P
Q
L
T
A
V
Y
D
C
A
T
E
A
R
K
------
H
G
I
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
E
I
Y
Q
G
R
Q
F
K
V
Y
R
G
M
G
S
V
G
A
M
---
E
-------------------------
L
V
P
E
G
I
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
E
F
----
L
R
E
N
A
-----
Q
F
I
R
M
S
G
A
G
L
L
E
S
----
V
Q
I
T
--------
65
PsiBlast_CBE
62.79
61%
-101
- C2 -
4MY8
4
?
C:
[116-366]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
L
L
V
G
A
A
V
G
V
--
T
--
A
DA
M
T
--
R
I
D
A
L
V
K
A
S
V
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
P
--
S
-
L
N
I
I
A
G
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
P
Q
L
T
A
V
Y
D
C
A
T
E
A
R
K
------
H
G
I
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
E
I
Y
Q
G
R
Q
F
K
V
Y
R
G
M
G
S
V
G
A
M
---
E
K
-----------------------
K
L
V
P
E
G
I
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
E
F
----
L
R
E
N
A
-----
Q
F
I
R
M
S
G
A
G
L
L
------------------
43
PsiBlast_CBE
62.25
61%
-96
- C2 -
4QM1
3
?
C:
[116-375]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
L
L
V
G
A
A
V
G
V
--
T
--
A
DA
M
T
--
R
I
D
A
L
V
K
A
S
V
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
P
--
S
-
L
N
I
I
A
G
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
P
Q
L
T
A
V
Y
D
C
A
T
E
A
R
K
------
H
G
I
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
E
I
Y
Q
G
R
Q
F
K
V
Y
R
G
M
G
S
V
G
A
M
------------------------------
V
P
E
G
I
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
E
F
----
L
R
E
N
A
-----
Q
F
I
R
M
S
G
A
G
L
L
------
V
Q
I
---------
67
PsiBlast_CBE
62.06
61%
-95
- C2 -
4MY8
9
?
A:
[116-367]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
L
L
V
G
A
A
V
G
V
--
T
--
A
D
A
M
T
--
R
I
D
A
L
V
K
A
S
V
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
P
--
S
-
L
N
I
I
A
G
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
P
Q
L
T
A
V
Y
D
C
A
T
E
A
R
K
------
H
G
I
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
E
I
Y
Q
G
R
Q
F
K
V
Y
R
G
M
G
S
V
G
A
M
---
E
K
G
S
K
---------------------
L
V
P
E
G
I
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
E
F
----
L
R
E
N
A
-----
Q
F
I
R
M
S
G
A
G
L
L
E
-----------------