@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_0771: (2015-12-18 )
MWITQEITPYLRKEYTIEAKLLDVRSEHNILEIFKSKDFGEIAMLNRQLLFKNFLHIESELLAHMGGCTKKELREVLIVDGFDLELAHQLFKYDTRIDFVQADEKILDSFISFFPHFHEVKNNKNFTHAKQLLDLDIKKYDLILCLQEPDIHKIDGLKRMLKEDGVFISVAKHPLLEHVSMQNALKNLGDFFPITIPFVAPLRILSNKGYIYASFKTHPLKDLMTPKIEALKSVRYYNEDIHRAAFALPKNLQEVFKDNIKS
Atome Classification :
(20 SA)
---------------......--.-..10.........20........30.....---...40......--..50-..---.-..-...60........70........80........90..-.--.--....100--.......110...----..----.--------.--------120-...------..-.----.130-.........140..-.-...----.----150------...----..--------.------.---------..160.......170.....---------------..180.......190.......200...--.--...210--.......220...-------------------.-.---.-.--.--.-230-.----.......240.......250.......260
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
---------------MWI
T
Q
E
--
I
-
T
P
Y
-
L
R
K
E
Y
T
I
E
A
K
L
L
DVRSEH
N
I
L
E
I
F
KS---KDF
G
E
I
A
M
L
N
R
--
Q
L
L
F
-
K
N
---
F
-
L
H
-
I
E
S
E
L
L
A
HMGGC
T
K
K
E
L
R
E
V
L
I
VDGF
D
L
E
L
A
H
Q
L
F
K
Y-D--T--RI
D
F
VQA--
D
E
K
I
L
D
S
F
I
S
F
F
P
----
H
F
----
H
--------
E
--------VKN-NKN------
F
T
-
H
----
A
K
---
Q
L
L
D
LDIK
K
Y
D
L
I
L
-
C
-LQE----P----D--------I
H
K
----
I
D
--------
G
------
L
---------
K
R
M
L
K
ED
G
V
F
I
S
V
A
K
H
P
L
L
E
---------------
H
V
S
M
Q
N
A
L
K
N
LGDFFPI
T
I
P
F
V
A
P
L
R
I
L--S--NK
G
Y
I
Y
--
A
SFKTH
P
L
--
K
D
L-------------------M-
T
---
P
-
K
--
I
--
E
-
A
-
L
-
K
----
S
V
R
Y
Y
N
E
D
I
H
R
A
A
FAL
P
K
N
L
Q
E
V
F
K
D
NIKS
2
PsiBlast_PDB
99.26
95%
-118
- C3 -
2CMH
-
SPEE_HELPY
A:
[1-262]
---------------
M
W
I
T
Q
E
--
I
-
T
P
Y
-
L
R
K
E
Y
T
I
E
A
K
L
L
D
V
R
S
E
H
N
I
L
E
I
F
K
S
---
K
D
F
G
E
I
A
M
L
N
R
--
Q
L
L
F
-
K
N
---
F
-
L
H
-
I
E
S
E
L
L
A
H
M
G
G
C
T
K
K
E
L
K
E
V
L
I
V
D
G
F
D
L
E
L
A
H
Q
L
F
K
Y
-
D
--
T
--
H
I
D
F
V
Q
A
--
D
E
K
I
L
D
S
F
I
S
F
F
P
----
H
F
----
H
--------
E
--------
V
K
N
-
N
K
N
------
F
T
-
H
----
A
K
---
Q
L
L
D
L
D
I
K
K
Y
D
L
I
F
-
C
-
L
Q
E
----
P
----
D
--------
I
H
R
----
I
D
--------
G
------
L
---------
K
R
M
L
K
E
D
G
V
F
I
S
V
A
K
H
P
L
L
E
---------------
H
V
S
M
Q
N
A
L
K
N
M
G
G
V
F
S
V
A
M
P
F
V
A
P
L
R
I
L
--
S
--
N
K
G
Y
I
Y
--
A
S
F
K
T
H
P
L
--
K
D
L
-------------------
M
-
T
---
P
-
K
--
I
--
E
-
A
-
L
-
T
----
S
V
R
Y
Y
N
E
D
I
H
R
A
A
F
A
L
P
K
N
L
Q
E
V
F
K
D
N
I
K
S
1
PsiBlast_PDB
97.36
95%
-115
- C3 -
2CMG
-
SPEE_HELPY
A:
[1-262]
---------------
M
W
I
T
Q
E
--
I
-
T
P
Y
-
L
R
K
E
Y
T
I
E
A
K
L
L
D
V
R
S
E
H
N
I
L
E
I
F
K
S
---
K
D
F
G
E
I
A
M
L
N
R
--
Q
L
L
F
-
K
N
---
F
-
L
H
-
I
E
S
E
L
L
A
H
M
G
G
C
T
K
K
E
L
K
E
V
L
I
V
D
G
F
D
L
E
L
A
H
Q
L
F
K
Y
-
D
--
T
--
H
I
D
F
V
Q
A
--
D
E
K
I
L
D
S
F
I
S
F
F
P
----
H
F
----
H
--------
E
--------
V
K
N
-
N
K
N
------
F
T
-
H
----
A
K
---
Q
L
L
D
L
D
I
K
K
Y
D
L
I
F
-
C
-
L
Q
E
----
P
----
D
--------
I
H
R
----
I
D
--------
G
------
L
---------
K
R
M
L
K
E
D
G
V
F
I
S
V
A
K
H
P
L
L
E
---------------
H
V
S
M
Q
N
A
L
K
N
M
G
G
V
F
S
V
A
M
P
F
V
A
P
L
R
I
L
--
S
--
N
K
G
Y
I
Y
--
A
S
F
K
T
H
P
L
--
K
D
L
-------------------
M
-
T
---
P
-
K
--
I
--
E
-
A
-
L
-
T
----
S
V
R
Y
Y
N
E
D
I
H
R
A
A
F
A
L
P
K
N
L
Q
E
V
F
K
D
N
I
K
S
32
HHSearch
92.57
90%
-103
- C3 -
2CMG
-
SPEE_HELPY
A:
[1-262]
---------------
M
W
I
T
Q
E
--
I
-
T
P
Y
-
L
R
K
E
Y
T
I
E
A
K
L
L
D
V
R
S
E
H
N
I
L
E
I
F
K
S
---
K
D
F
G
E
I
A
M
L
N
R
--
Q
-
L
L
-
F
K
---
N
F
L
H
-
I
E
S
E
L
L
A
H
M
G
G
C
T
K
K
E
L
K
E
V
L
I
V
D
G
F
D
L
E
L
A
H
Q
L
F
K
Y
-
D
--
T
--
H
I
D
F
V
Q
A
--
D
E
K
I
L
D
S
F
I
S
F
F
P
----
H
F
----
H
--------
E
---------
V
K
N
N
K
N
------
F
T
-
H
----
A
K
---
Q
L
L
D
L
D
I
K
K
Y
D
L
I
F
C
L
-
Q
E
P
----
D
-------------
I
H
R
----
I
D
--------
G
------
L
---------
K
R
M
L
K
E
D
G
V
F
I
S
V
A
K
H
P
L
L
E
---------------
H
V
S
M
Q
N
A
L
K
N
M
G
G
V
F
S
V
A
M
P
F
V
A
P
L
R
I
L
--
S
--
N
K
G
Y
I
Y
--
A
S
F
K
T
H
P
L
--
K
D
L
---------------------
M
---
T
-
P
--
K
I
-
E
-
A
-
L
-
T
----
S
V
R
Y
Y
N
E
D
I
H
R
A
A
F
A
L
P
K
N
L
Q
E
V
F
K
D
N
I
K
S
24
Fugue
69.06
20%
-92
- C3 -
1INL
-
SPEE_THEMA
A:
[2-296]
RTLKELERE
L
Q
P
R
QH
L
W
Y
F
E
Y
--
Y
-
T
G
N
N
V
G
L
F
M
K
M
N
R
V
I
Y
S
G
Q
S
D
I
Q
R
I
D
I
F
E
N
---
P
D
L
G
V
V
F
A
L
D
G
--
I
T
M
T
-
T
E
---
K
D
E
F
-
M
Y
H
E
M
L
A
H
V
P
M
F
L
H
P
N
P
K
K
V
L
I
I
G
G
G
D
G
G
T
L
R
E
V
L
K
H
-
D
--
S
VE
K
A
I
L
C
E
V
--
D
G
L
V
I
E
A
A
R
K
Y
L
K
----
Q
T
----
S
--------
C
--------
G
F
D
-
D
P
R
------
A
E
-
I
V
IAN
G
A
---
E
Y
V
R
K
F
K
N
E
F
D
V
I
I
-
I
-
D
S
L
----
F
----
T
--------
E
E
F
----
Y
Q
--------
A
------
C
---------
Y
D
A
L
K
E
D
G
V
F
S
A
E
T
E
D
P
F
Y
D
---------------
I
G
W
F
K
L
A
Y
R
R
I
S
K
V
F
P
I
T
R
V
Y
L
G
F
M
T
T
Y
--
P
SG
M
W
S
Y
T
F
--
A
S
K
G
I
D
P
I
--
K
D
F
-------------------
D
-
P
---
E
-
K
--
V
--
R
-
K
-
F
N
K
----
E
L
K
Y
Y
N
E
E
V
H
V
A
S
F
A
L
P
N
F
V
K
K
E
L
G
L
M
---
23
Fugue
68.75
19%
-101
- C3 -
1INL
-
SPEE_THEMA
A:
[2-296]
RTLKELERE
L
Q
P
R
QH
L
W
Y
F
E
Y
--
Y
-
T
G
N
N
V
G
L
F
M
K
M
N
R
V
I
Y
S
G
Q
S
D
I
Q
R
I
D
I
F
E
N
---
P
D
L
G
V
V
F
A
L
D
G
--
I
T
M
T
T
E
K
---
D
-
E
F
-
M
Y
H
E
M
L
A
H
V
P
M
F
L
H
P
N
P
K
K
V
L
I
I
G
G
G
D
G
G
T
L
R
E
V
L
K
H
-
D
--
S
VE
K
A
I
L
C
E
V
--
D
G
L
V
I
E
A
A
R
K
Y
L
K
QTSC
G
F
----
D
-----------------------
D
PR
A
E
I
V
I
A
-
N
----
G
A
---
E
Y
V
R
K
F
K
N
E
F
D
V
I
I
-
I
-
D
S
--------------------
L
F
T
E
E
F
Y
Q
--------
A
------
C
---------
Y
D
A
L
K
E
D
G
V
F
S
A
E
T
E
D
P
F
Y
D
---------------
I
G
W
F
K
L
A
Y
R
R
I
S
K
V
F
P
I
T
R
V
Y
L
G
F
M
T
T
Y
--
P
--
S
G
M
W
S
Y
--
T
F
A
S
K
-
G
I
--
D
P
I
-------------------
K
-
D
---
F
-
D
--
P
--
E
-
K
-
V
-
R
K
FNK
E
L
K
Y
Y
N
E
E
V
H
V
A
S
F
A
L
P
N
F
V
K
K
E
L
G
L
M
---
36
HHSearch
67.97
21%
-95
- C3 -
1INL
-
SPEE_THEMA
A:
[17-295]
---------------
L
W
Y
F
E
Y
--
Y
T
G
N
N
-
V
G
L
F
M
K
M
N
R
V
I
Y
S
G
Q
S
D
I
Q
R
I
D
I
F
E
N
---
P
D
L
G
V
V
F
A
L
D
G
--
I
T
M
T
-
T
E
---
K
D
E
F
-
M
Y
H
E
M
L
A
H
V
P
M
F
L
H
P
N
P
K
K
V
L
I
I
G
G
G
D
G
G
T
L
R
E
V
L
K
H
-
D
SV
E
--
K
A
I
L
C
E
V
--
D
G
L
V
I
E
A
A
R
K
Y
L
K
----
Q
T
----
S
CGFD----
D
--------
P
R
A
-
E
I
V
------
I
A
-
N
----
G
A
---
E
Y
V
R
K
F
K
N
E
F
D
V
I
I
I
D
-
S
------------LFT-----
E
E
F
----
Y
Q
--------
A
------
C
---------
Y
D
A
L
K
E
D
G
V
F
S
A
E
T
E
D
P
F
Y
D
---------------
I
G
W
F
K
L
A
Y
R
R
I
S
K
V
F
P
I
T
R
V
Y
L
G
F
M
T
T
Y
PS
G
--
M
W
S
Y
T
F
--
A
S
K
G
I
D
P
I
--
K
D
F
---------------------
D
---
P
-
E
--
K
V
R
K
-
F
-
N
-
K
----
E
L
K
Y
Y
N
E
E
V
H
V
A
S
F
A
L
P
N
F
V
K
K
E
L
G
L
M
---
10
PsiBlast_PDB
66.77
23%
-100
- C3 -
1IY9
-
SPEE_BACSU
A:
[4-275]
---------------
L
W
Y
T
E
K
--
Q
-
T
K
N
-
F
G
I
T
M
K
V
N
K
T
L
H
T
E
Q
T
E
F
Q
H
L
E
M
V
E
T
---
E
E
F
G
N
M
L
F
L
D
G
--
M
V
M
T
-
S
E
KDE
F
-
V
Y
---
H
E
M
V
A
H
V
P
L
F
T
H
P
N
P
E
H
V
L
V
V
G
G
G
D
G
G
V
I
R
E
I
L
K
H
-
P
--
S
VK
K
A
T
L
V
D
I
--
D
G
K
V
I
E
Y
S
K
K
F
L
P
----
S
I
----
A
GKLDDPR
V
D
--------
V
Q
V
-
D
D
G
------
F
M
-
H
----
I
A
---
K
S
E
N
----
Q
Y
D
V
I
M
-
V
D
S
T
E
----
P
----
V
--------
G
P
A
----
V
N
LFTK
G
F
Y
A
G
------
I
---------
A
K
A
L
K
E
D
G
I
F
V
A
Q
T
D
N
P
W
F
T
---------------
P
E
L
I
T
N
V
Q
R
D
V
K
E
I
F
P
I
T
K
L
Y
T
A
N
I
P
T
Y
--
P
--
S
G
L
W
T
F
T
I
G
S
K
K
Y
D
P
L
AV
E
D
S
-------------------
R
-
F
---
F
-
D
--
I
--
E
-
T
----------
K
Y
Y
T
K
D
I
H
K
A
A
F
V
L
P
K
F
V
S
D
L
I
------
15
PsiBlast_PDB
64.43
20%
-82
- C3 -
4YUW
2
?
A:
[36-295]
-----------------------------------
V
E
K
V
L
Y
D
A
P
T
K
F
Q
H
L
T
I
F
E
S
DPK
G
P
W
G
T
V
M
A
L
D
G
--
C
I
Q
V
-
T
D
---
Y
-
D
E
F
V
Y
H
E
V
L
G
H
T
S
L
C
S
H
P
K
P
E
R
V
L
I
I
G
G
G
D
G
G
V
L
R
E
V
L
R
H
-
G
--
T
VE
H
C
D
L
V
D
I
--
D
G
E
V
M
E
Q
S
K
Q
H
F
P
----
Q
I
----
S
--------
R
SLADPR
A
T
V
R
V
-
G
D
G
------
L
A
-
F
----
V
R
---
Q
T
P
D
---
N
T
Y
D
V
V
I
-
I
D
T
T
D
----
P
AG--
P
--------
A
S
K
----
L
F
--------
G
E
A
F
Y
K
D
V
---------
L
R
I
L
K
P
D
G
I
C
C
N
Q
G
E
S
I
W
L
D
L
E
L
I
E
K
M
S
R
F
I
R
E
T
G
F
A
S
V
Q
Y
A
L
M
H
V
P
T
Y
P
C
G
S
I
G
T
L
----
V
C
--
S
--
K
K
A
G
V
D
--
V
T
K
P
L
R
P
V
--
E
D
M
---------------------------------
P
-
F
-
A
-
K
----
D
L
K
Y
Y
D
S
E
M
H
K
A
S
F
A
L
P
R
F
A
R
H
I
N
N
-----
42
HHSearch
64.15
19%
-88
- C3 -
2B2C
-
?
A:
[41-314]
--------------------
G
--
A
-
W
P
G
-
Q
A
F
S
L
Q
V
K
K
V
L
F
H
E
K
S
K
Y
Q
D
V
L
V
F
E
S
---
T
T
Y
G
N
V
L
V
L
D
G
--
I
V
Q
A
-
T
E
---
R
D
E
F
-
S
Y
Q
E
M
L
A
H
L
P
M
F
A
H
P
D
P
K
R
V
L
I
I
G
G
G
D
G
G
I
L
R
E
V
L
K
H
E
S
V-
E
--
K
V
T
M
C
E
I
--
D
E
M
V
I
D
V
A
K
K
F
L
P
----
G
M
----
S
CGFS----
H
--------
P
K
L
-
D
L
F
------
C
G
-
D
----
G
F
---
E
F
L
K
N
H
K
N
E
F
D
V
I
I
T
D
-
S
S
---------------------
Y
----
Y
E
--------
L
------
L
---------
R
D
A
L
K
E
D
G
I
L
S
S
Q
G
E
S
V
W
L
H
---------------
L
P
L
I
A
H
L
V
A
F
N
R
K
I
F
P
A
V
T
Y
A
Q
S
I
V
S
T
Y
PS
G
--
S
M
G
Y
L
I
--
C
A
K
N
A
N
R
D
--
V
T
T
-------------------
P
A
R
T
L
T
A
-
E
--
Q
--
I
-
K
-
A
-
L
----
N
L
R
F
Y
N
S
E
V
H
K
A
A
F
V
L
P
Q
F
V
K
N
A
L
E
-----
33
HHSearch
64.10
20%
-84
* C3 *
2I7C
3
?
A:
[4-283]
---------------
K
W
F
S
E
F
S
I
M
-
W
P
G
-
Q
A
F
S
L
K
I
K
K
I
L
Y
E
T
K
S
K
Y
Q
N
V
L
V
F
E
S
---
T
T
Y
G
K
V
L
V
L
D
G
--
V
I
Q
L
-
T
E
---
K
D
E
F
-
A
Y
H
E
M
M
T
H
V
P
M
T
V
S
K
E
P
K
N
V
L
V
V
G
G
G
D
G
G
I
I
R
E
L
C
K
Y
-
K
SV
E
--
N
I
D
I
C
E
I
--
D
E
T
V
I
E
V
S
K
I
Y
F
K
----
N
I
SCGY
E
--------
D
--------
K
R
V
-
N
V
F
------
I
E
-
D
----
A
S
---
K
F
L
E
N
V
T
N
T
Y
D
V
I
I
V
D
-
S
S
D
----
P
IGP-
A
ETLFN---
Q
N
F
----
Y
E
--------
K
------
I
---------
Y
N
A
L
K
P
N
G
Y
C
V
A
Q
C
E
S
L
W
I
H
---------------
V
G
T
I
K
N
M
I
G
Y
A
K
K
L
F
K
K
V
E
Y
A
N
I
S
I
P
T
Y
PC
G
--
C
I
G
I
L
C
--
C
S
K
T
D
T
G
L
--
T
K
P
-------------------
N
-
K
---
K
-
L
--
E
--
S
-
K
E
F
-
A
----
D
L
K
Y
Y
N
Y
E
N
H
S
A
A
F
K
L
P
A
F
L
L
K
E
I
E
N
I
---
7
PsiBlast_PDB
64.09
22%
-99
- C3 -
3RW9
1
SPEE_HUMAN
A:
[47-302]
-------------------------------------------
R
S
R
Y
Q
D
I
L
V
F
R
S
---
K
T
Y
G
N
V
L
V
L
D
G
VI
Q
C
T
E
-
R
D
---
E
-
F
S
-
Y
Q
-
E
M
I
A
N
L
P
L
C
S
H
P
N
P
R
K
V
L
I
I
G
G
G
D
G
G
V
L
R
E
V
V
K
H
-
P
--
S
--
V
E
S
V
V
Q
C
E
I
D
E
D
V
I
Q
V
S
K
K
F
L
P
----
G
M
----
A
--------
I
--------
G
Y
S
-
S
S
K
------
L
T
L
H
----
V
G
D
G
F
E
F
M
K
Q
N
Q
D
A
F
D
V
I
I
-
T
-
D
S
--------------------
G
P
----
A
E
--------
S
------
L
FKES
Y
Y
Q
L
M
K
T
A
L
K
E
D
G
V
L
C
C
Q
G
E
C
Q
W
L
----------------
H
L
D
L
---
I
K
E
M
R
Q
F
C
Q
S
L
F
P
V
V
A
-------------
Y
A
Y
--
C
T
I
P
T
Y
P
S
--
G
Q
I
G
F
M
L
C
S
KNPSTNFQEPV
Q
P
L
-
T
---
Q
-
Q
--
Q
--
V
-
A
-
Q
-
M
----
Q
L
K
Y
Y
N
S
D
V
H
R
A
A
F
V
L
P
E
F
A
R
K
A
L
N
D
----
5
PsiBlast_PDB
63.87
22%
-95
- C3 -
2O07
2
SPEE_HUMAN
A:
[47-302]
-------------------------------------------
R
S
R
Y
Q
D
I
L
V
F
R
S
---
K
T
Y
G
N
V
L
V
L
D
G
VI
Q
C
T
E
-
R
D
---
E
-
F
S
-
Y
Q
-
E
M
I
A
N
L
P
L
C
S
H
P
N
P
R
K
V
L
I
I
G
G
G
D
G
G
V
L
R
E
V
V
K
H
-
P
--
S
--
V
E
S
V
V
Q
C
E
I
D
E
D
V
I
Q
V
S
K
K
F
L
P
----
G
M
----
A
--------
I
--------
G
Y
S
-
S
S
K
------
L
T
L
H
----
V
G
D
G
F
E
F
M
K
Q
N
Q
D
A
F
D
V
I
I
-
T
-
D
S
S
-------------------------------------------E
S
Y
Y
Q
L
M
--
K
T
A
L
K
E
D
G
V
L
C
C
Q
G
E
C
Q
W
L
----------------
H
L
D
L
---
I
K
E
M
R
Q
F
C
Q
S
L
F
P
V
V
A
-------------
Y
A
Y
--
C
T
I
P
T
Y
P
S
--
G
Q
I
G
F
M
L
C
S
KNPSTNFQEPV
Q
P
L
-
T
---
Q
-
Q
--
Q
--
V
-
A
-
Q
-
M
----
Q
L
K
Y
Y
N
S
D
V
H
R
A
A
F
V
L
P
E
F
A
R
K
A
L
N
D
----
40
HHSearch
63.86
20%
-87
- C3 -
2PT6
3
?
A:
[42-321]
---------------
K
W
F
S
E
F
S
I
M
-
W
P
G
-
Q
A
F
S
L
K
I
K
K
I
L
Y
E
T
K
S
K
Y
Q
N
V
L
V
F
E
S
---
T
T
Y
G
K
V
L
V
L
D
G
--
V
I
Q
L
-
T
E
---
K
D
E
F
-
A
Y
H
E
M
M
T
H
V
P
M
T
V
S
K
E
P
K
N
V
L
V
V
G
G
G
D
G
G
I
I
R
E
L
C
K
Y
-
K
SV
E
--
N
I
D
I
C
E
I
--
D
E
T
V
I
E
V
S
K
I
Y
F
K
----
N
I
SCGY
E
--------
D
--------
K
R
V
-
N
V
F
------
I
E
-
D
----
A
S
---
K
F
L
E
N
V
T
N
T
Y
D
V
I
I
V
D
-
S
S
D
----
P
----
I
GPAETLFN
Q
N
F
----
Y
E
--------
K
------
I
---------
Y
N
A
L
K
P
N
G
Y
C
V
A
Q
C
E
S
L
W
I
H
---------------
V
G
T
I
K
N
M
I
G
Y
A
K
K
L
F
K
K
V
E
Y
A
N
I
S
I
P
T
Y
PC
G
--
C
I
G
I
L
C
--
C
S
K
T
D
T
G
L
--
T
K
P
-------------------
N
-
K
---
K
-
L
--
E
--
S
-
K
E
F
-
A
----
D
L
K
Y
Y
N
Y
E
N
H
S
A
A
F
K
L
P
A
F
L
L
K
E
I
E
N
I
---
4
PsiBlast_PDB
63.86
22%
-89
- C3 -
2O06
4
SPEE_HUMAN
A:
[47-302]
-------------------------------------------
R
S
R
Y
Q
D
I
L
V
F
R
S
---
K
T
Y
G
N
V
L
V
L
D
G
VI
Q
C
T
E
-
R
D
---
E
-
F
S
-
Y
Q
-
E
M
I
A
N
L
P
L
C
S
H
P
N
P
R
K
V
L
I
I
G
G
G
D
G
G
V
L
R
E
V
V
K
H
-
P
--
S
--
V
E
S
V
V
Q
C
E
I
D
E
D
V
I
Q
V
S
K
K
F
L
P
----
G
M
----
A
--------
I
--------
G
Y
S
-
S
S
K
------
L
T
L
H
----
V
G
D
G
F
E
F
M
K
Q
N
Q
D
A
F
D
V
I
I
-
T
-
D
S
S
----
D
----
P
--------
M
G
P
----
A
E
--------
S
------
L
FK
E
S
Y
Y
Q
L
M
K
T
A
L
K
E
D
G
V
L
C
C
Q
G
E
C
Q
W
L
----------------
H
L
D
L
---
I
K
E
M
R
Q
F
C
Q
S
L
F
P
V
V
A
-------------
Y
A
Y
--
C
T
I
P
T
Y
P
S
--
G
Q
I
G
F
M
L
C
S
KNPSTNFQEPV
Q
P
L
-
T
---
Q
-
Q
--
Q
--
V
-
A
-
Q
-
M
----
Q
L
K
Y
Y
N
S
D
V
H
R
A
A
F
V
L
P
E
F
A
R
K
A
L
N
D
V
S
--
6
PsiBlast_PDB
63.80
22%
-95
- C3 -
2O0L
1
SPEE_HUMAN
A:
[47-302]
-------------------------------------------
R
S
R
Y
Q
D
I
L
V
F
R
S
---
K
T
Y
G
N
V
L
V
L
D
G
VI
Q
C
T
E
-
R
D
---
E
-
F
S
-
Y
Q
-
E
M
I
A
N
L
P
L
C
S
H
P
N
P
R
K
V
L
I
I
G
G
G
D
G
G
V
L
R
E
V
V
K
H
-
P
--
S
--
V
E
S
V
V
Q
C
E
I
D
E
D
V
I
Q
V
S
K
K
F
L
P
----
G
M
----
A
--------
I
--------
G
Y
S
-
S
S
K
------
L
T
L
H
----
V
G
D
G
F
E
F
M
K
Q
N
Q
D
A
F
D
V
I
I
-
T
-
D
S
S
-------------------------------------------E
S
Y
Y
Q
L
M
--
K
T
A
L
K
E
D
G
V
L
C
C
Q
G
E
C
Q
W
L
----------------
H
L
D
L
---
I
K
E
M
R
Q
F
C
Q
S
L
F
P
V
V
A
-------------
Y
A
Y
--
C
T
I
P
T
Y
P
S
--
G
Q
I
G
F
M
L
C
S
KNPSTNFQEPV
Q
P
L
-
T
---
Q
-
Q
--
Q
--
V
-
A
-
Q
-
M
----
Q
L
K
Y
Y
N
S
D
V
H
R
A
A
F
V
L
P
E
F
A
R
K
A
L
N
D
----
14
PsiBlast_PDB
63.53
20%
-79
- C3 -
4YUV
1
?
A:
[36-295]
-----------------------------------
V
E
K
V
L
Y
D
A
P
T
K
F
Q
H
L
T
I
F
E
S
DPK
G
P
W
G
T
V
M
A
L
D
G
--
C
I
Q
V
-
T
D
---
Y
-
D
E
F
V
Y
H
E
V
L
G
H
T
S
L
C
S
H
P
K
P
E
R
V
L
I
I
G
G
G
D
G
G
V
L
R
E
V
L
R
H
-
G
--
T
VE
H
C
D
L
V
D
I
--
D
G
E
V
M
E
Q
S
K
Q
H
F
P
----
Q
I
----
S
--------
R
SLADPR
A
T
V
R
V
-
G
D
G
------
L
A
-
F
----
V
R
---
Q
T
P
D
---
N
T
Y
D
V
V
I
-
I
D
T
T
D
----
P
AG--
P
--------
A
S
K
----
L
F
--------
G
E
A
F
Y
K
D
V
---------
L
R
I
L
K
P
D
G
I
C
C
N
Q
G
E
S
I
W
L
D
L
E
L
I
E
K
M
S
R
F
I
R
E
T
G
F
A
S
V
Q
Y
A
L
M
H
V
P
T
Y
P
C
G
S
I
G
T
L
----
V
C
--
S
--
K
K
A
G
V
D
--
V
T
K
P
L
R
P
V
--
E
D
M
---------------------------------
P
-
F
-
A
-
K
----
D
L
K
Y
Y
D
S
E
M
H
K
A
S
F
A
L
P
R
F
A
R
H
I
N
N
-----
37
HHSearch
63.34
21%
-78
- C3 -
2O07
2
SPEE_HUMAN
A:
[21-302]
---------------
G
W
F
R
E
T
C
S
L
-
W
P
G
-
Q
A
L
S
L
Q
V
E
Q
L
L
H
H
R
R
S
R
Y
Q
D
I
L
V
F
R
S
---
K
T
Y
G
N
V
L
V
L
D
G
--
V
I
Q
C
-
T
E
---
R
D
E
F
-
S
Y
Q
E
M
I
A
N
L
P
L
C
S
H
P
N
P
R
K
V
L
I
I
G
G
G
D
G
G
V
L
R
E
V
V
K
H
-
P
SV
E
--
S
V
V
Q
C
E
I
--
D
E
D
V
I
Q
V
S
K
K
F
L
P
----
G
M
----
A
IGYS----
S
--------
S
K
L
-
T
L
H
------
V
G
-
D
----
G
F
---
E
F
M
K
Q
N
Q
D
A
F
D
V
I
I
T
D
-
S
S
-------------------
E
S
Y
----
Y
Q
--------
L
------
M
---------
K
T
A
L
K
E
D
G
V
L
C
C
Q
G
E
C
Q
W
L
H
---------------
L
D
L
I
K
E
M
R
Q
F
C
Q
S
L
F
P
V
V
A
Y
A
Y
C
T
I
P
T
Y
PS
G
--
Q
I
G
F
M
L
--
C
S
K
N
P
S
T
N
--
F
Q
E
-------------------
P
-
V
---
Q
P
L
T
Q
Q
--
Q
V
A
-
Q
-
M
----
Q
L
K
Y
Y
N
S
D
V
H
R
A
A
F
V
L
P
E
F
A
R
K
A
L
N
D
----
41
HHSearch
63.15
23%
-84
- C3 -
1IY9
-
SPEE_BACSU
A:
[4-275]
---------------
L
W
Y
T
E
K
--
Q
-
T
K
N
-
F
G
I
T
M
K
V
N
K
T
L
H
T
E
Q
T
E
F
Q
H
L
E
M
V
E
T
---
E
E
F
G
N
M
L
F
L
D
G
--
M
V
M
T
-
S
E
---
K
D
E
F
-
V
Y
H
E
M
V
A
H
V
P
L
F
T
H
P
N
P
E
H
V
L
V
V
G
G
G
D
G
G
V
I
R
E
I
L
K
H
P
S
V-
K
--
K
A
T
L
V
D
I
--
D
G
K
V
I
E
Y
S
K
K
F
L
P
----
S
I
----
A
GKLD----
D
--------
P
R
V
-
D
V
Q
------
V
D
-
D
----
G
F
---
M
H
I
A
K
S
E
N
Q
Y
D
V
I
M
V
D
-
S
T
E
PVGP
A
VNLF
T
--------
K
G
F
----
Y
A
--------
G
------
I
---------
A
K
A
L
K
E
D
G
I
F
V
A
Q
T
D
N
P
W
F
T
---------------
P
E
L
I
T
N
V
Q
R
D
V
K
E
I
F
P
I
T
K
L
Y
T
A
N
I
P
T
Y
PS
G
--
L
W
T
F
T
I
--
G
S
K
K
Y
D
P
L
--
A
V
E
---------------------
D
---
S
-
R
-----
F
-
F
-
D
-
I
----
E
T
K
Y
Y
T
K
D
I
H
K
A
A
F
V
L
P
K
F
V
S
D
L
I
------
16
PsiBlast_PDB
63.02
20%
-77
- C3 -
4YUX
2
?
A:
[36-295]
-----------------------------------
V
E
K
V
L
Y
D
A
P
T
K
F
Q
H
L
T
I
F
E
S
DPK
G
P
W
G
T
V
M
A
L
D
G
--
C
I
Q
V
-
T
D
---
Y
-
D
E
F
V
Y
H
E
V
L
G
H
T
S
L
C
S
H
P
K
P
E
R
V
L
I
I
G
G
G
D
G
G
V
L
R
E
V
L
R
H
-
G
--
T
VE
H
C
D
L
V
D
I
--
D
G
E
V
M
E
Q
S
K
Q
H
F
P
----
Q
I
----
S
--------
R
SLADPR
A
T
V
R
V
-
G
D
G
------
L
A
-
F
----
V
R
---
Q
T
P
D
---
N
T
Y
D
V
V
I
-
I
D
T
T
D
----
P
AG--
P
--------
A
S
K
----
L
F
--------
G
E
A
F
Y
K
D
V
---------
L
R
I
L
K
P
D
G
I
C
C
N
Q
G
E
S
I
W
L
D
L
E
L
I
E
K
M
S
R
F
I
R
E
T
G
F
A
S
V
Q
Y
A
L
M
H
V
P
T
Y
P
C
G
S
I
G
T
L
----
V
C
--
S
--
K
K
A
G
V
D
--
V
T
K
P
L
R
P
V
--
E
D
M
---------------------------------
P
-
F
-
A
-
K
----
D
L
K
Y
Y
D
S
E
M
H
K
A
S
F
A
L
P
R
F
A
R
H
I
N
N
-----
3
PsiBlast_PDB
62.88
22%
-90
- C3 -
2O05
1
SPEE_HUMAN
A:
[47-302]
-------------------------------------------
R
S
R
Y
Q
D
I
L
V
F
R
S
---
K
T
Y
G
N
V
L
V
L
D
G
VI
Q
C
T
E
-
R
D
---
E
-
F
S
-
Y
Q
-
E
M
I
A
N
L
P
L
C
S
H
P
N
P
R
K
V
L
I
I
G
G
G
D
G
G
V
L
R
E
V
V
K
H
-
P
--
S
--
V
E
S
V
V
Q
C
E
I
D
E
D
V
I
Q
V
S
K
K
F
L
P
----
G
M
----
A
--------
I
--------
G
Y
S
-
S
S
K
------
L
T
L
H
----
V
G
D
G
F
E
F
M
K
Q
N
Q
D
A
F
D
V
I
I
-
T
-
D
S
S
----
D
----
P
--------
M
G
P
----
A
E
--------
S
------
L
FKES
Y
Y
Q
L
M
K
T
A
L
K
E
D
G
V
L
C
C
Q
G
E
C
Q
W
L
----------------
H
L
D
L
---
I
K
E
M
R
Q
F
C
Q
S
L
F
P
V
V
A
-------------
Y
A
Y
--
C
T
I
P
T
Y
P
S
--
G
Q
I
G
F
M
L
C
S
KNPSTNFQEPV
Q
P
L
-
T
---
Q
-
Q
--
Q
--
V
-
A
-
Q
-
M
----
Q
L
K
Y
Y
N
S
D
V
H
R
A
A
F
V
L
P
E
F
A
R
K
A
L
N
D
----