@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_0790: (2015-12-18 )
MKVFDYEDVQLIPNKCIVNSRSECDTTVILGKHAFKMPIVPANMQTIINESIAEFLAENGYFYIMHRFNGSARIPFVKKMKERQLISSISVGVKKEECLFVEELAKQGLTPDYITIDIAHGHSNSVIEMIQRIKTRLPETFVIAGNVGTPEAVRELENAGADATKVGIGPGKVCITKIKTGFGTGGWQLAALRWCAKAARKPIIADGGIRTHGDIAKSIRFGATMVMIGSLFAGHEESSGETKIENGIAYKEYFGSASEFQKGEKKNIEGKKIWIQHKGSLKNTLIEMHQDLQSSISYAGGRDLEAIRKVDYVIVKNSIFNGDTI
Atome Classification :
(30 SA)
.........10........20.....----...--30----.-....-...40........50........60......---.----.70----..-------..-----------------------.-----....80-----------------------------------------.------------------------------.---------------------------.-..--------------------------------------------------------------------------------------------------...90-------------.--........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......---200--........210.......220.......230.......240-.......250.--.....---------.-------260-------......-.270.......280.......290.......300..-...-..310....-.-...320...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MKVFDYEDVQLIP
N
K
CIVNSRSECD
T
----
T
V
I
--
L
G----K-HAFK-MPIVP
A
N
M
Q
T
I
I
N
E
S
I
A
E
F
L
AEN
G
Y
F
Y
I
M
H
R---F----NG-----SA-------R
I
-----------------------
P
-----
F
V
K
K
M
K
-----------------------------------------
E
------------------------------
R
---------------------------
Q
-
L
I
--------------------------------------------------------------------------------------------------
S
S
I
S--------------V--GVK
K
E
E
C
L
F
V
E
E
L
A
KQGLTP
D
Y
I
T
I
D
I
AHGHS
N
S
V
I
E
M
I
Q
R
I
K
T
RLP
E
T
F
V
I
AGNVG
T
P
E
A
V
R
E
L
E
NAGADATKVGIGPG
K
V
C
I
T
K
IKTGFGTGG
W
Q
L
A
A
L
R
W
C
A
K
A
A---RK---
P
I
IADGGIR
T
H
G
D
I
A
K
S
I
RFG
A
T
M
V
M
I
G
S
L
FAGHEESSGET-KIENG
I
A
Y
K
E
Y--FG
S
A
S
---------
E
-------FQK-------GEKKNI-EG
K
K
I
W
I
Q
HKG
S
L
K
N
T
L
I
E
M
H
Q
D
L
Q
S
SISYAGGR
D
L
-
E
A
I
-
R
KV-
D
Y
V
I
V
-K-NSIFNGDTI
1
PsiBlast_PDB
97.32
79%
-112
- C1 -
2A1Y
1
GUAC_BACAN
A:
[13-330]
--
V
F
D
Y
E
D
I
Q
L
I
P
A
K
C
I
V
N
S
R
S
E
C
D
T
----
T
V
T
--
L
G
----
K
-
H
K
F
K
-
L
P
V
V
P
A
N
M
Q
T
I
I
D
E
R
I
A
T
Y
L
A
E
N
N
Y
F
Y
I
M
H
R
---
F
----
Q
P
-----
E
K
-------
R
I
-----------------------
S
-----
F
I
R
D
M
Q
-----------------------------------------
S
------------------------------
R
---------------------------
G
-
L
I
--------------------------------------------------------------------------------------------------
A
S
I
S
--------------
V
--
G
V
K
E
D
E
Y
E
F
V
Q
Q
L
A
A
E
H
L
T
P
E
Y
I
T
I
D
I
A
H
G
H
S
N
A
V
I
N
M
I
Q
H
I
K
K
H
L
P
E
S
F
V
I
A
G
N
V
G
T
P
E
A
V
R
E
L
E
N
A
G
A
D
A
T
K
V
G
I
G
P
G
K
V
C
I
T
K
I
K
T
G
F
G
T
G
G
W
Q
L
A
A
L
R
W
C
A
K
A
A
---
S
K
---
P
I
I
A
D
G
G
I
R
T
N
G
D
V
A
K
S
I
R
F
G
A
T
M
V
M
I
G
S
L
F
A
G
H
E
E
S
P
G
E
T
-
I
E
K
---
L
Y
K
E
Y
--
F
G
S
-----------------------------------------
F
V
E
H
K
G
S
L
E
D
T
L
I
E
M
E
Q
D
L
Q
S
S
I
S
Y
A
G
G
T
K
L
-
D
S
I
-
R
T
V
-
D
Y
V
V
V
-
K
-
N
S
I
F
-----
54
PsiBlast_CBE
72.64
37%
-90
- C1 -
4Q33
5
?
F:
[12-339]
---
Y
T
F
D
D
V
L
L
V
P
N
K
S
E
V
L
P
N
E
V
S
L
K
----
T
Q
L
--
T
K
----
K
-
I
Q
L
N
-
I
P
L
M
S
A
S
M
D
T
V
T
E
S
K
M
A
I
A
M
A
R
E
G
G
I
G
I
I
H
K
NMT
I
----
E
D
-----
Q
A
-------
R
------------------------------
E
V
D
R
V
K
-----------------------------------------
R
------------------------------
S
---------------------------
G
G
L
L
--------------------------------------------------------------------------------------------------
C
G
A
S
--------------
I
--
G
V
T
N
D
M
M
E
R
V
D
A
V
V
K
A
K
V
--
D
V
I
V
L
D
T
A
H
G
H
S
K
G
V
I
E
G
V
K
R
I
K
A
K
Y
P
E
L
Q
V
I
A
G
N
I
A
T
P
E
A
V
R
D
L
A
E
A
G
A
D
C
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
A
G
V
G
V
--
P
Q
L
T
A
V
M
D
C
A
E
E
G
---
K
K
LGI
P
V
I
A
D
G
G
L
K
Y
S
G
D
I
V
K
A
L
A
A
G
A
C
A
A
M
M
G
S
I
F
A
G
C
E
E
A
P
G
A
I
-
E
I
Y
Q
G
R
S
Y
K
V
Y
--
R
G
M
G
S
LGAMAK------------------------
K
F
V
P
E
G
V
E
G
R
I
A
Y
K
G
H
L
A
D
T
I
Y
Q
L
I
G
G
I
K
S
G
M
G
Y
L
G
A
P
T
L
-
E
N
L
-
Y
E
N
-
A
N
F
V
V
-
Q
-
T
S
A
G
F
R
E
S
H
32
PsiBlast_CBE
72.04
36%
-90
- C1 -
4MY9
7
?
H:
[35-353]
---
L
T
F
D
D
V
L
L
V
P
A
K
S
D
V
L
P
R
E
V
S
V
K
----
T
V
L
--
S
E
----
S
-
L
Q
L
N
-
I
P
L
I
S
A
G
M
D
T
V
T
E
A
D
M
A
I
A
M
A
R
Q
G
G
L
G
I
I
H
K
N--
M
----
S
I
-----
E
Q
-------
Q
A
-----------------------
E
-----
Q
V
D
K
V
K
-----------------------------------------
R
------------------------------
S
---------------------------
G
G
L
L
--------------------------------------------------------------------------------------------------
V
G
A
A
--------------
V
--
G
V
T
A
D
A
M
T
R
I
D
A
L
V
K
A
S
V
--
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
P
S
L
N
I
I
A
G
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
--
P
Q
L
T
A
V
Y
D
C
A
T
E
A
---
R
K
HGI
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
-
E
I
Y
Q
G
R
Q
F
K
V
Y
--
R
G
M
G
S
VGAMEK-------------------------
L
V
P
E
G
I
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
-
E
F
L
-
R
E
N
-
A
Q
F
I
R
-
M
-
S
G
A
G
L
L
E
S
H
6
PsiBlast_PDB
72.00
36%
-90
- C1 -
4MYX
6
?
A:
[35-353]
---
L
T
F
D
D
V
L
L
V
P
A
K
S
D
V
L
P
R
E
V
S
V
K
----
T
V
L
--
S
E
----
S
-
L
Q
L
N
-
I
P
L
I
S
A
G
M
D
T
V
T
E
A
D
M
A
I
A
M
A
R
Q
G
G
L
G
I
I
H
K
N--
M
----
S
I
-----
E
Q
-------
Q
A
-----------------------
E
-----
Q
V
D
K
V
K
-----------------------------------------
R
------------------------------
S
---------------------------
G
G
L
L
--------------------------------------------------------------------------------------------------
V
G
A
A
--------------
V
--
G
V
T
A
D
A
M
T
R
I
D
A
L
V
K
A
S
V
--
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
P
S
L
N
I
I
A
G
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
--
P
Q
L
T
A
V
Y
D
C
A
T
E
A
---
R
K
H
G
I
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
-
E
I
Y
Q
G
R
Q
F
K
V
Y
--
R
G
M
G
S
V
G
A
M
E
K------------------------
K
L
V
P
E
G
I
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
-
E
F
L
-
R
E
N
-
A
Q
F
I
R
-
M
-
S
G
A
G
L
L
E
S
H
30
PsiBlast_CBE
71.99
36%
-90
- C1 -
4MYX
5
?
B:
[35-353]
---
L
T
F
D
D
V
L
L
V
P
A
K
S
D
V
L
P
R
E
V
S
V
K
----
T
V
L
--
S
E
----
S
-
L
Q
L
N
-
I
P
L
I
S
A
G
M
D
T
V
T
E
A
D
M
A
I
A
M
A
R
Q
G
G
L
G
I
I
H
K
N--
M
----
S
I
-----
E
Q
-------
Q
A
-----------------------
E
-----
Q
V
D
K
V
K
-----------------------------------------
R
------------------------------
S
---------------------------
G
G
L
L
--------------------------------------------------------------------------------------------------
V
G
A
A
--------------
V
--
G
V
T
A
D
A
M
T
R
I
D
A
L
V
K
A
S
V
--
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
P
S
L
N
I
I
A
G
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
--
P
Q
L
T
A
V
Y
D
C
A
T
E
A
---
R
K
H
G
I
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
-
E
I
Y
Q
G
R
Q
F
K
V
Y
--
R
G
M
G
S
VGAMEKGSK---------------------
K
L
V
P
E
G
I
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
-
E
F
L
-
R
E
N
-
A
Q
F
I
R
-
M
-
S
G
A
G
L
L
E
S
H
23
PsiBlast_CBE
71.89
36%
-90
- C1 -
4QM1
3
?
B:
[35-353]
---
L
T
F
D
D
V
L
L
V
P
A
K
S
D
V
L
P
R
E
V
S
V
K
----
T
V
L
--
S
E
----
S
-
L
Q
L
N
-
I
P
L
I
S
A
G
M
D
T
V
T
E
A
D
M
A
I
A
M
A
R
Q
G
G
L
G
I
I
H
K
N--
M
----
S
I
-----
E
Q
-------
Q
A
-----------------------
E
-----
Q
V
D
K
V
K
-----------------------------------------
R
------------------------------
S
---------------------------
G
G
L
L
--------------------------------------------------------------------------------------------------
V
G
A
A
--------------
V
--
G
V
T
A
D
A
M
T
R
I
D
A
L
V
K
A
S
V
--
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
P
S
L
N
I
I
A
G
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
--
P
Q
L
T
A
V
Y
D
C
A
T
E
A
---
R
K
H
G
I
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
-
E
I
Y
Q
G
R
Q
F
K
V
Y
--
R
G
M
G
S
V
G
A
M
E
K------------------------
K
L
V
P
E
G
I
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
-
E
F
L
-
R
E
N
-
A
Q
F
I
R
-
M
-
S
G
A
G
L
L
H
V
Q
3
PsiBlast_PDB
71.89
36%
-91
- C1 -
4MY1
3
?
A:
[35-353]
---
L
T
F
D
D
V
L
L
V
P
A
K
S
D
V
L
P
R
E
V
S
V
K
----
T
V
L
--
S
E
----
S
-
L
Q
L
N
-
I
P
L
I
S
A
G
M
D
T
V
T
E
A
D
M
A
I
A
M
A
R
Q
G
G
L
G
I
I
H
K
N--
M
----
S
I
-----
E
Q
-------
Q
A
-----------------------
E
-----
Q
V
D
K
V
K
-----------------------------------------
R
------------------------------
S
---------------------------
G
G
L
L
--------------------------------------------------------------------------------------------------
V
G
A
A
--------------
V
--
G
V
T
A
D
A
M
T
R
I
D
A
L
V
K
A
S
V
--
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
P
S
L
N
I
I
A
G
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
--
P
Q
L
T
A
V
Y
D
C
A
T
E
A
---
R
K
H
G
I
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
-
E
I
Y
Q
G
R
Q
F
K
V
Y
--
R
G
M
G
S
VGAMEK-------------------------
L
V
P
E
G
I
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
-
E
F
L
-
R
E
N
-
A
Q
F
I
R
-
M
-
S
G
A
G
L
L
E
S
H
28
PsiBlast_CBE
71.77
36%
-92
- C1 -
4MYX
2
?
D:
[35-353]
---
L
T
F
D
D
V
L
L
V
P
A
K
S
D
V
L
P
R
E
V
S
V
K
----
T
V
L
--
S
E
----
S
-
L
Q
L
N
-
I
P
L
I
S
A
G
M
D
T
V
T
E
A
D
M
A
I
A
M
A
R
Q
G
G
L
G
I
I
H
K
N--
M
----
S
I
-----
E
Q
-------
Q
A
-----------------------
E
-----
Q
V
D
K
V
K
-----------------------------------------
R
------------------------------
S
---------------------------
G
G
L
L
--------------------------------------------------------------------------------------------------
V
G
A
A
--------------
V
--
G
V
T
A
D
A
M
T
R
I
D
A
L
V
K
A
S
V
--
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
P
S
L
N
I
I
A
G
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
--
P
Q
L
T
A
V
Y
D
C
A
T
E
A
---
R
K
H
G
I
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
-
E
I
Y
Q
G
R
Q
F
K
V
Y
--
R
G
M
G
S
V
G
A
M
E
K
G----------------------
K
K
L
V
P
E
G
I
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
-
E
F
L
-
R
E
N
-
A
Q
F
I
R
-
M
-
S
G
A
G
L
L
E
S
H
4
PsiBlast_PDB
71.60
36%
-90
- C1 -
4MYA
4
?
A:
[35-353]
---
L
T
F
D
D
V
L
L
V
P
A
K
S
D
V
L
P
R
E
V
S
V
K
----
T
V
L
--
S
E
----
S
-
L
Q
L
N
-
I
P
L
I
S
A
G
M
D
T
V
T
E
A
D
M
A
I
A
M
A
R
Q
G
G
L
G
I
I
H
K
N--
M
----
S
I
-----
E
Q
-------
Q
A
-----------------------
E
-----
Q
V
D
K
V
K
-----------------------------------------
R
------------------------------
S
---------------------------
G
G
L
L
--------------------------------------------------------------------------------------------------
V
G
A
A
--------------
V
--
G
V
T
A
D
A
M
T
R
I
D
A
L
V
K
A
S
V
--
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
P
S
L
N
I
I
A
G
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
--
P
Q
L
T
A
V
Y
D
C
A
T
E
A
---
R
K
H
G
I
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
-
E
I
Y
Q
G
R
Q
F
K
V
Y
--
R
G
M
G
S
V
G
A
M
E
K-----------------------
K
K
L
V
P
E
G
I
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
-
E
F
L
-
R
E
N
-
A
Q
F
I
R
-
M
-
S
G
A
G
L
L
E
S
H
57
PsiBlast_CBE
71.55
37%
-90
- C1 -
4Q33
3
?
C:
[12-339]
---
Y
T
F
D
D
V
L
L
V
P
N
K
S
E
V
L
P
N
E
V
S
L
K
----
T
Q
L
--
T
K
----
K
-
I
Q
L
N
-
I
P
L
M
S
A
S
M
D
T
V
T
E
S
K
M
A
I
A
M
A
R
E
G
G
I
G
I
I
H
K
NMT
I
----
E
D
-----
Q
A
-------
R
------------------------------
E
V
D
R
V
K
-----------------------------------------
R
------------------------------
S
---------------------------
G
G
L
L
--------------------------------------------------------------------------------------------------
C
G
A
S
--------------
I
--
G
V
T
N
D
M
M
E
R
V
D
A
V
V
K
A
K
V
--
D
V
I
V
L
D
T
A
H
G
H
S
K
G
V
I
E
G
V
K
R
I
K
A
K
Y
P
E
L
Q
V
I
A
G
N
I
A
T
P
E
A
V
R
D
L
A
E
A
G
A
D
C
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
A
G
V
G
V
--
P
Q
L
T
A
V
M
D
C
A
E
E
G
---
K
K
L
G
I
P
V
I
A
D
G
G
L
K
Y
S
G
D
I
V
K
A
L
A
A
G
A
C
A
A
M
M
G
S
I
F
A
G
C
E
E
A
P
G
A
I
-
E
I
Y
Q
G
R
S
Y
K
V
Y
--
R
G
M
G
S
LGAMAK-------------------------
F
V
P
E
G
V
E
G
R
I
A
Y
K
G
H
L
A
D
T
I
Y
Q
L
I
G
G
I
K
S
G
M
G
Y
L
G
A
P
T
L
-
E
N
L
-
Y
E
N
-
A
N
F
V
V
-
Q
-
T
S
A
G
F
R
E
S
H
36
PsiBlast_CBE
71.24
36%
-88
- C1 -
4MY9
4
?
D:
[35-353]
---
L
T
F
D
D
V
L
L
V
P
A
K
S
D
V
L
P
R
E
V
S
V
K
----
T
V
L
--
S
E
----
S
-
L
Q
L
N
-
I
P
L
I
S
A
G
M
D
T
V
T
E
A
D
M
A
I
A
M
A
R
Q
G
G
L
G
I
I
H
K
N--
M
----
S
I
-----
E
Q
-------
Q
A
-----------------------
E
-----
Q
V
D
K
V
K
-----------------------------------------
R
------------------------------
S
---------------------------
G
G
L
L
--------------------------------------------------------------------------------------------------
V
G
A
A
--------------
V
--
G
V
T
A
D
A
M
T
R
I
D
A
L
V
K
A
S
V
--
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
P
S
L
N
I
I
A
G
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
--
P
Q
L
T
A
V
Y
D
C
A
T
E
A
---
R
K
H
G
I
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
-
E
I
Y
Q
G
R
Q
F
K
V
Y
--
R
G
M
G
S
VGAME--------------------------
L
V
P
E
G
I
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
-
E
F
L
-
R
E
N
-
A
Q
F
I
R
-
M
-
S
G
A
G
L
L
E
S
H
60
PsiBlast_CBE
71.10
37%
-88
- C1 -
4Q32
3
?
C:
[12-339]
---
Y
T
F
D
D
V
L
L
V
P
N
K
S
E
V
L
P
N
E
V
S
L
K
----
T
Q
L
--
T
K
----
K
-
I
Q
L
N
-
I
P
L
M
S
A
S
M
D
T
V
T
E
S
K
M
A
I
A
M
A
R
E
G
G
I
G
I
I
H
K
NMT
I
----
E
D
-----
Q
A
-------
R
------------------------------
E
V
D
R
V
K
-----------------------------------------
R
------------------------------
S
---------------------------
G
G
L
L
--------------------------------------------------------------------------------------------------
C
G
A
S
--------------
I
--
G
V
T
N
D
M
M
E
R
V
D
A
V
V
K
A
K
V
--
D
V
I
V
L
D
T
A
H
G
H
S
K
G
V
I
E
G
V
K
R
I
K
A
K
Y
P
E
L
Q
V
I
A
G
N
I
A
T
P
E
A
V
R
D
L
A
E
A
G
A
D
C
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
A
G
V
G
V
--
P
Q
L
T
A
V
M
D
C
A
E
E
G
---
K
K
L
G
I
P
V
I
A
D
G
G
L
K
Y
S
G
D
I
V
K
A
L
A
A
G
A
C
A
A
M
M
G
S
I
F
A
G
C
E
E
A
P
G
A
I
-
E
I
Y
Q
G
R
S
Y
K
V
Y
--
R
G
M
G
S
LGAMAK-------------------------
F
V
P
E
G
V
E
G
R
I
A
Y
K
G
H
L
A
D
T
I
Y
Q
L
I
G
G
I
K
S
G
M
G
Y
L
G
A
P
T
L
-
E
N
L
-
Y
E
N
-
A
N
F
V
V
-
Q
-
T
S
A
G
F
R
E
S
H
31
PsiBlast_CBE
71.07
36%
-90
- C1 -
4MYA
3
?
B:
[35-353]
---
L
T
F
D
D
V
L
L
V
P
A
K
S
D
V
L
P
R
E
V
S
V
K
----
T
V
L
--
S
E
----
S
-
L
Q
L
N
-
I
P
L
I
S
A
G
M
D
T
V
T
E
A
D
M
A
I
A
M
A
R
Q
G
G
L
G
I
I
H
K
N--
M
----
S
I
-----
E
Q
-------
Q
A
-----------------------
E
-----
Q
V
D
K
V
K
-----------------------------------------
R
------------------------------
S
---------------------------
G
G
L
L
--------------------------------------------------------------------------------------------------
V
G
A
A
--------------
V
--
G
V
T
A
D
A
M
T
R
I
D
A
L
V
K
A
S
V
--
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
P
S
L
N
I
I
A
G
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
--
P
Q
L
T
A
V
Y
D
C
A
T
E
A
---
R
K
H
G
I
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
-
E
I
Y
Q
G
R
Q
F
K
V
Y
--
R
G
M
G
S
V
G
A
M
E
K------------------------
K
L
V
P
E
G
I
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
-
E
F
L
-
R
E
N
-
A
Q
F
I
R
-
M
-
S
G
A
G
L
L
E
S
H
58
PsiBlast_CBE
70.94
37%
-88
- C1 -
4Q33
3
?
B:
[12-339]
---
Y
T
F
D
D
V
L
L
V
P
N
K
S
E
V
L
P
N
E
V
S
L
K
----
T
Q
L
--
T
K
----
K
-
I
Q
L
N
-
I
P
L
M
S
A
S
M
D
T
V
T
E
S
K
M
A
I
A
M
A
R
E
G
G
I
G
I
I
H
K
NMT
I
----
E
D
-----
Q
A
-------
R
------------------------------
E
V
D
R
V
K
-----------------------------------------
R
------------------------------
S
---------------------------
G
G
L
L
--------------------------------------------------------------------------------------------------
C
G
A
S
--------------
I
--
G
V
T
N
D
M
M
E
R
V
D
A
V
V
K
A
K
V
--
D
V
I
V
L
D
T
A
H
G
H
S
K
G
V
I
E
G
V
K
R
I
K
A
K
Y
P
E
L
Q
V
I
A
G
N
I
A
T
P
E
A
V
R
D
L
A
E
A
G
A
D
C
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
A
G
V
G
V
--
P
Q
L
T
A
V
M
D
C
A
E
E
G
---
K
K
L
G
I
P
V
I
A
D
G
G
L
K
Y
S
G
D
I
V
K
A
L
A
A
G
A
C
A
A
M
M
G
S
I
F
A
G
C
E
E
A
P
G
A
I
-
E
I
Y
Q
G
R
S
Y
K
V
Y
--
R
G
M
G
S
LGAMA--------------------------
F
V
P
E
G
V
E
G
R
I
A
Y
K
G
H
L
A
D
T
I
Y
Q
L
I
G
G
I
K
S
G
M
G
Y
L
G
A
P
T
L
-
E
N
L
-
Y
E
N
-
A
N
F
V
V
-
Q
-
T
S
A
G
F
R
E
S
H
38
PsiBlast_CBE
70.76
36%
-90
- C1 -
4MY9
5
?
B:
[35-353]
---
L
T
F
D
D
V
L
L
V
P
A
K
S
D
V
L
P
R
E
V
S
V
K
----
T
V
L
--
S
E
----
S
-
L
Q
L
N
-
I
P
L
I
S
A
G
M
D
T
V
T
E
A
D
M
A
I
A
M
A
R
Q
G
G
L
G
I
I
H
K
N--
M
----
S
I
-----
E
Q
-------
Q
A
-----------------------
E
-----
Q
V
D
K
V
K
-----------------------------------------
R
------------------------------
S
---------------------------
G
G
L
L
--------------------------------------------------------------------------------------------------
V
G
A
A
--------------
V
--
G
V
T
A
D
A
M
T
R
I
D
A
L
V
K
A
S
V
--
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
P
S
L
N
I
I
A
G
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
--
P
Q
L
T
A
V
Y
D
C
A
T
E
A
---
R
K
H
G
I
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
-
E
I
Y
Q
G
R
Q
F
K
V
Y
--
R
G
M
G
S
V
G
A
M
E
K
G
SK----------------------
L
V
P
E
G
I
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
-
E
F
L
-
R
E
N
-
A
Q
F
I
R
-
M
-
S
G
A
G
L
L
E
S
H
35
PsiBlast_CBE
70.62
36%
-88
- C1 -
4MY9
3
?
E:
[35-353]
---
L
T
F
D
D
V
L
L
V
P
A
K
S
D
V
L
P
R
E
V
S
V
K
----
T
V
L
--
S
E
----
S
-
L
Q
L
N
-
I
P
L
I
S
A
G
M
D
T
V
T
E
A
D
M
A
I
A
M
A
R
Q
G
G
L
G
I
I
H
K
N--
M
----
S
I
-----
E
Q
-------
Q
A
-----------------------
E
-----
Q
V
D
K
V
K
-----------------------------------------
R
------------------------------
S
---------------------------
G
G
L
L
--------------------------------------------------------------------------------------------------
V
G
A
A
--------------
V
--
G
V
T
A
D
A
M
T
R
I
D
A
L
V
K
A
S
V
--
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
P
S
L
N
I
I
A
G
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
--
P
Q
L
T
A
V
Y
D
C
A
T
E
A
---
R
K
H
G
I
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
-
E
I
Y
Q
G
R
Q
F
K
V
Y
--
R
G
M
G
S
V
G
A
M
E
K-------------------------
L
V
P
E
G
I
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
-
E
F
L
-
R
E
N
-
A
Q
F
I
R
-
M
-
S
G
A
G
L
L
E
S
H
61
PsiBlast_CBE
70.50
37%
-86
- C1 -
4Q32
3
?
B:
[12-339]
---
Y
T
F
D
D
V
L
L
V
P
N
K
S
E
V
L
P
N
E
V
S
L
K
----
T
Q
L
--
T
K
----
K
-
I
Q
L
N
-
I
P
L
M
S
A
S
M
D
T
V
T
E
S
K
M
A
I
A
M
A
R
E
G
G
I
G
I
I
H
K
NMT
I
----
E
D
-----
Q
A
-------
R
------------------------------
E
V
D
R
V
K
-----------------------------------------
R
------------------------------
S
---------------------------
G
G
L
L
--------------------------------------------------------------------------------------------------
C
G
A
S
--------------
I
--
G
V
T
N
D
M
M
E
R
V
D
A
V
V
K
A
K
V
--
D
V
I
V
L
D
T
A
H
G
H
S
K
G
V
I
E
G
V
K
R
I
K
A
K
Y
P
E
L
Q
V
I
A
G
N
I
A
T
P
E
A
V
R
D
L
A
E
A
G
A
D
C
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
A
G
V
G
V
--
P
Q
L
T
A
V
M
D
C
A
E
E
G
---
K
K
L
G
I
P
V
I
A
D
G
G
L
K
Y
S
G
D
I
V
K
A
L
A
A
G
A
C
A
A
M
M
G
S
I
F
A
G
C
E
E
A
P
G
A
I
-
E
I
Y
Q
G
R
S
Y
K
V
Y
--
R
G
M
G
S
L
G
A
M
A
K
G-------------------------
V
P
E
G
V
E
G
R
I
A
Y
K
G
H
L
A
D
T
I
Y
Q
L
I
G
G
I
K
S
G
M
G
Y
L
G
A
P
T
L
-
E
N
L
-
Y
E
N
-
A
N
F
V
V
-
Q
-
T
S
A
G
F
R
E
S
H
48
PsiBlast_CBE
70.47
36%
-90
- C1 -
4MY1
3
?
B:
[35-353]
---
L
T
F
D
D
V
L
L
V
P
A
K
S
D
V
L
P
R
E
V
S
V
K
----
T
V
L
--
S
E
----
S
-
L
Q
L
N
-
I
P
L
I
S
A
G
M
D
T
V
T
E
A
D
M
A
I
A
M
A
R
Q
G
G
L
G
I
I
H
K
N--
M
----
S
I
-----
E
Q
-------
Q
A
-----------------------
E
-----
Q
V
D
K
V
K
-----------------------------------------
R
------------------------------
S
---------------------------
G
G
L
L
--------------------------------------------------------------------------------------------------
V
G
A
A
--------------
V
--
G
V
T
A
D
A
M
T
R
I
D
A
L
V
K
A
S
V
--
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
P
S
L
N
I
I
A
G
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
--
P
Q
L
T
A
V
Y
D
C
A
T
E
A
---
R
K
H
G
I
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
-
E
I
Y
Q
G
R
Q
F
K
V
Y
--
R
G
M
G
S
V
G
A
M
E
K
G
S-----------------------
L
V
P
E
G
I
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
-
E
F
L
-
R
E
N
-
A
Q
F
I
R
-
M
-
S
G
A
G
L
L
E
S
H
25
PsiBlast_CBE
70.41
36%
-90
- C1 -
4MYX
18
?
G:
[35-353]
---
L
T
F
D
D
V
L
L
V
P
A
K
S
D
V
L
P
R
E
V
S
V
K
----
T
V
L
--
S
E
----
S
-
L
Q
L
N
-
I
P
L
I
S
A
G
M
D
T
V
T
E
A
D
M
A
I
A
M
A
R
Q
G
G
L
G
I
I
H
K
N--
M
----
S
I
-----
E
Q
-------
Q
A
-----------------------
E
-----
Q
V
D
K
V
K
-----------------------------------------
R
------------------------------
S
---------------------------
G
G
L
L
--------------------------------------------------------------------------------------------------
V
G
A
A
--------------
V
--
G
V
T
A
D
A
M
T
R
I
D
A
L
V
K
A
S
V
--
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
P
S
L
N
I
I
A
G
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
--
P
Q
L
T
A
V
Y
D
C
A
T
E
A
---
R
K
HGI
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
-
E
I
Y
Q
G
R
Q
F
K
V
Y
--
R
G
M
G
S
VGAMEKGSK--------------------
K
K
L
V
P
E
G
I
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
-
E
F
L
-
R
E
N
-
A
Q
F
I
R
-
M
-
S
G
A
G
L
L
E
S
H
17
PsiBlast_PDB
70.32
35%
-93
- C1 -
3R2G
-
?
A:
[10-326]
-----
F
D
D
V
L
L
V
P
S
Y
N
H
H
E
S
R
R
V
V
E
T
----
T
S
T
D
R
L
G
----
K
-
L
T
L
N
-
L
P
V
I
S
A
N
M
D
T
I
T
E
S
N
M
A
N
F
M
H
S
K
G
A
M
G
A
L
H
R
---
F
----
M
T
I
----
E
E
-------
N
I
-----------------------
Q
-----
E
F
K
K
C
K
-----------------------------------------
G
------------------------------
P
---------------------------
V
-
F
V
--------------------------------------------------------------------------------------------------
S
-----------------
V
--
G
C
T
E
N
E
L
Q
R
A
E
A
L
R
D
A
G
--
A
D
F
F
C
V
D
V
A
H
A
H
A
K
Y
V
G
K
T
L
K
S
L
R
Q
L
L
G
S
R
C
I
M
A
G
N
V
A
T
Y
A
G
A
D
Y
L
A
S
C
G
A
D
I
I
K
A
G
I
G
G
G
S
V
C
S
T
R
I
K
T
G
F
G
V
--
P
M
L
T
C
I
Q
D
C
S
R
A
D
---
R
S
----
I
V
A
D
G
G
I
K
T
S
G
D
I
V
K
A
L
A
F
G
A
D
F
V
M
I
G
G
M
L
A
G
S
A
P
T
P
G
E
V
F
Q
K
D
D
G
S
K
V
K
R
Y
--
R
G
M
A
S
---------
R
E
A
Q
E
A
F
L
G
Q
M
-------
H
E
W
K
T
A
-
E
G
V
A
T
E
V
P
F
K
E
N
P
D
G
I
I
A
D
I
I
G
G
L
R
S
G
L
T
Y
A
G
A
D
S
I
S
E
L
Q
-
R
K
L
-
N
Y
V
I
V
-
T
-
Q
A
G
R
-----
121
HHSearch
69.48
34%
-101
- C1 -
3USB
4
?
A:
[33-493]
-
E
G
L
T
F
D
D
V
L
L
V
P
A
K
S
D
V
L
-
P
R
E
V
S
V
----
K
T
V
--
L
S
----
E
S
L
Q
L
N
-
I
P
L
I
S
A
G
M
D
T
V
T
E
A
D
M
A
I
A
M
A
R
Q
G
G
L
G
I
I
H
K
---
N
----
M
S
I
----
E
Q
Q
A
E
Q
V
D
K
V
K
R
SESGVIS
D
P
F
F
L
T
PEHQV
Y
D
A
E
H
-----
L
M
G
K
Y
R
-----------------------------------------
I
------------------------------
S
---------------------------
G
-
V
P
V
V
NNLDERKLV
G
I
I
T
N
R
D
M
R
F
IQDYSIKISDVMTK
E
Q
L
I
T
A
P
VGTT
L
S
E
A
E
K
I
L
Q
K
YKIE
K
L
P
L
V
D
NNGVLQ
G
L
I
T
I
K
D
I
E
K
V
I
E
F
PN
S
A
K
D
KQG
R
L
L
V
G
A
A
--------------
V
--
G
V
T
A
D
A
M
T
R
I
D
A
L
V
K
A
S
--
V
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
P
S
L
N
I
I
A
G
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
P
--
Q
L
T
A
V
Y
D
C
A
T
E
A
R
K
H
G
I
---
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
-
E
I
Y
Q
G
R
Q
F
K
V
------------------------------------------------
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
-
E
F
L
-
R
E
N
A
Q
F
I
R
M
-
S
-
G
A
G
L
L
----
14
PsiBlast_PDB
69.21
32%
-78
- C1 -
2A7R
3
GMPR2_HUMAN
A:
[28-356]
---
L
D
F
K
D
V
L
L
R
P
K
R
S
T
L
K
S
R
S
E
V
D
L
----
T
R
S
--
F
S
F
RNS
K
-
Q
T
Y
S
G
V
P
I
I
A
A
N
M
D
T
V
G
T
F
E
M
A
K
V
L
C
K
F
S
L
F
T
A
V
H
K
---
H
----
Y
S
-----
L
V
-------
Q
W
-----------------------
Q
E
----
F
A
G
Q
N
P
-----------------------------------------
D
------------------------------
C
---------------------------
L
-
E
H
--------------------------------------------------------------------------------------------------
L
A
A
S
--------------
S
--
G
T
G
S
S
D
F
E
Q
L
E
Q
I
L
E
A
I
P
Q
V
K
Y
I
C
L
D
V
A
N
G
Y
S
E
H
F
V
E
F
V
K
D
V
R
K
R
F
P
Q
H
T
I
M
A
G
N
V
V
T
G
E
M
V
E
E
L
I
L
S
G
A
D
I
I
K
V
G
I
G
P
G
S
V
C
T
T
R
K
K
T
G
V
G
Y
--
P
Q
L
S
A
V
M
E
C
A
D
A
A
H
G
L
K
G
---
H
I
I
S
D
G
G
C
S
C
P
G
D
V
A
K
A
F
G
A
G
A
D
F
V
M
L
G
G
M
L
A
G
H
S
E
S
G
G
E
L
-
I
E
R
D
G
K
K
Y
K
L
F
--
Y
G
M
S
S
---------
E
-------
M
A
M
K
K
YAGGV
A
E
Y
R
A
S
-
E
G
K
T
V
E
V
P
F
K
G
D
V
E
H
T
I
R
D
I
L
G
G
I
R
S
T
C
T
Y
V
G
A
A
K
L
-
K
E
L
S
R
R
T
-
T
F
I
R
V
-
T
Q---------
124
HHSearch
69.02
34%
-86
- C1 -
1ZFJ
1
IMDH_STRPY
A:
[10-477]
-
K
G
Y
T
F
D
D
V
L
L
I
P
A
E
S
H
V
L
-
P
N
E
V
D
L
----
K
T
K
--
L
A
----
D
N
L
T
L
N
-
I
P
I
I
T
A
A
M
D
T
V
T
G
S
K
M
A
I
A
I
A
R
A
G
G
L
G
V
I
H
K
---
N
----
M
S
I
----
T
E
Q
A
E
E
V
R
K
V
K
R
SENGVIID
P
F
F
L
T
PEHK
V
S
E
A
E
E
-----
L
M
Q
R
Y
R
IS
G
V
P
I
V
ETLANRKLV
G
I
I
T
N
R
D
M
R
F
ISDYNAPISEHMTSE
H
L
V
T
A
A
VGTD
L
E
T
A
E
R
I
L
H
E
H
RIE
K
L
P
L
V
D
N
S
GRLS
G
L
I
T
I
K
D
I
E
K
V
I
E
F
PHAAKDEFG
R
-
L
L
--------------------------------------------------------------------------------------------------
V
A
A
A
--------------
V
--
G
V
T
S
D
T
F
E
R
A
E
A
L
F
E
A
G
--
A
D
A
I
V
I
D
T
A
H
G
H
S
A
G
V
L
R
K
I
A
E
I
R
A
H
F
P
N
R
T
L
I
A
G
N
I
A
T
A
E
G
A
R
A
L
Y
D
A
G
V
D
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
P
--
Q
V
T
A
I
Y
D
A
A
A
V
A
R
E
Y
G
K
---
T
I
I
A
D
G
G
I
K
Y
S
G
D
I
V
K
A
L
A
A
G
G
N
A
V
M
L
G
S
M
F
A
G
T
D
E
A
P
G
E
T
-
E
I
Y
Q
G
R
K
Y
K
T
Y
--
R
G
M
G
S
---------
I
AA-----
M
K
K
--------
N
K
L
V
P
-
E
G
I
E
G
R
V
A
Y
K
G
A
A
S
D
I
V
F
Q
M
L
G
G
I
R
S
G
M
G
Y
V
G
A
G
D
I
-
Q
E
L
-
H
E
N
A
Q
F
V
E
M
-
S
-
G
A
G
L
I
E
S
H
P
98
PsiBlast_CBE
64.97
33%
-101
- C1 -
4QQ3
3
?
A:
[12-333]
-
E
A
L
T
F
D
D
V
L
L
V
P
A
H
S
T
V
L
P
N
T
A
D
L
R
----
T
R
L
--
T
K
----
N
-
I
A
L
N
-
I
P
M
V
S
A
S
M
D
T
V
T
E
A
R
L
A
I
A
L
A
Q
E
G
G
I
G
F
I
H
K
---
N
MS
I
E
Q
Q
-----
A
A
-------
Q
V
-----------------------
H
-----
Q
V
K
I
S
G
-----------------------------------------
G
------------------------------
L
---------------------------
R
-
V
G
--------------------------------------------------------------------------------------------------
A
A
V
G
--------------
A
--
A
P
G
N
E
E
--
R
V
K
A
L
V
E
A
G
V
--
D
V
L
L
I
D
S
S
H
G
H
S
E
G
V
L
Q
R
I
R
E
T
R
A
A
Y
P
H
L
E
I
I
G
G
N
V
A
T
A
E
G
A
R
A
L
I
E
A
G
V
S
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
T
G
V
G
V
--
P
Q
I
T
A
I
A
D
A
A
G
V
A
---
N
E
Y
G
I
P
V
I
A
D
G
G
I
R
F
S
G
D
I
S
K
A
I
A
A
G
A
S
C
V
M
V
G
S
M
F
A
G
T
E
E
A
P
--------
G
R
S
Y
K
A
Y
R
G
M
G
------------------------------------------
R
I
A
Y
K
G
H
L
K
E
I
I
H
Q
Q
M
G
G
L
R
S
C
M
G
L
T
G
S
A
T
V
-
E
D
L
-
R
T
K
-
A
Q
F
V
R
-
I
-
S
G
A
------
79
PsiBlast_CBE
64.92
31%
-77
- C1 -
2BWG
2
GMPR1_HUMAN
D:
[32-359]
---
L
D
F
K
D
V
L
L
R
P
K
R
S
S
L
K
S
R
A
E
V
D
L
ERTF
T
F
R
--
N
S
----
K
-
Q
T
Y
S
G
I
P
I
I
V
A
N
M
D
T
V
G
T
F
E
M
A
A
V
M
S
Q
H
S
M
F
T
A
I
H
K
H--
Y
----
S
L
-----
D
D
-------
W
K
-----------------------
L
-----
F
A
T
N
H
P
-----------------------------------------
E
------------------------------
C
---------------------------
L
-
Q
N
--------------------------------------------------------------------------------------------------
V
A
V
S
--------------
S
--
G
S
G
Q
N
D
L
E
K
M
T
S
I
L
E
A
V
P
Q
V
K
F
I
C
L
D
V
A
N
G
Y
S
E
H
F
V
E
F
V
K
L
V
R
A
K
F
P
E
H
T
I
M
A
G
N
V
V
T
G
E
M
V
E
E
L
I
L
S
G
A
D
I
I
K
V
G
V
G
P
G
S
V
C
T
T
R
T
K
T
G
V
G
Y
--
P
Q
L
S
A
V
I
E
C
A
D
S
A
HGL
K
G
---
H
I
I
S
D
G
G
C
T
C
P
G
D
V
A
K
A
F
G
A
G
A
D
F
V
M
L
G
G
M
F
S
G
H
T
E
C
A
G
E
V
-
I
----
R
K
L
K
L
F
--
Y
G
M
S
S
---------
D
-------
T
A
M
NKHA----
E
Y
R
A
S
-
E
G
K
T
V
E
V
P
Y
K
G
D
V
E
N
T
I
L
D
I
L
G
G
L
R
S
T
C
T
Y
V
G
A
A
K
L
K
E
L
S
-
R
R
A
-
T
F
I
R
V
T-----------
103
PsiBlast_CBE
64.07
33%
-93
- C1 -
4IX2
2
?
B:
[12-333]
-
E
A
L
T
F
D
D
V
L
L
V
P
A
H
S
T
V
L
P
N
T
A
D
L
R
----
T
R
L
--
T
K
----
N
-
I
A
L
N
-
I
P
M
V
S
A
S
M
D
T
V
T
E
A
R
L
A
I
A
L
A
Q
E
G
G
I
G
F
I
H
K
---
N
MS
I
E
Q
Q
-----
A
A
-------
Q
V
-----------------------
H
-----
Q
V
K
I
S
G
-----------------------------------------
G
------------------------------
L
---------------------------
R
-
V
G
--------------------------------------------------------------------------------------------------
A
A
V
G
--------------
A
--
A
P
G
N
E
E
--
R
V
K
A
L
V
E
A
G
V
--
D
V
L
L
I
D
S
S
H
G
H
S
E
G
V
L
Q
R
I
R
E
T
R
A
A
Y
P
H
L
E
I
I
G
G
N
V
A
T
A
E
G
A
R
A
L
I
E
A
G
V
S
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
T
G
V
G
V
--
P
Q
I
T
A
I
A
D
A
A
G
V
A
---
N
E
Y
G
I
P
V
I
A
D
G
G
I
R
F
S
G
D
I
S
K
A
I
A
A
G
A
S
C
V
M
V
G
S
M
F
A
G
T
E
E
A
P
G
E
V
-
I
L
Y
Q
G
R
S
Y
K
A
Y
R
G
M
------------------------------------
P
-
E
G
I
E
G
R
I
A
Y
K
G
H
L
K
E
I
I
H
Q
Q
M
G
G
L
R
S
C
M
G
L
T
G
S
A
T
V
-
E
D
L
-
R
T
K
-
A
Q
F
V
R
-
I
-
S
G
A
G
M
K
E
S
H
127
HHSearch
60.93
32%
-82
- C1 -
2CU0
1
IMDH_PYRHO
A:
[13-469]
-
K
G
Y
T
F
D
D
V
L
L
I
P
Q
A
T
E
V
E
-
P
K
D
V
D
V
----
S
T
R
--
I
T
P---
N
-
V
K
L
N
-
I
P
I
L
S
A
A
M
D
T
V
T
E
W
E
M
A
V
A
M
A
R
E
G
G
L
G
V
I
H
R
---
N
----
M
G
I
E
E
Q
V
E
Q
-------
V
K
-----------------------
R
V
K
R
AE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KYKN
A
V
R
D
ENG
E
L
L
V
A
A
A
V
S
P
F
D
I
K
R
A
I
E
L
D
K
A
G
--
V
D
V
I
V
V
D
T
A
H
A
H
N
L
K
A
I
K
S
M
K
E
M
R
Q
K
V
-
D
A
D
F
I
V
G
N
I
A
N
P
K
A
V
D
D
L
--
T
F
A
D
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
A
G
V
G
V
P
--
Q
I
T
A
V
A
M
V
A
D
R
A
Q
E
Y
G
L
---
Y
V
I
A
D
G
G
I
R
Y
S
G
D
I
V
K
A
I
A
A
G
A
D
A
V
M
L
G
N
L
L
A
G
T
K
E
A
P
G
K
E
-
V
I
I
N
G
R
K
Y
K
Q
Y
--
R
G
M
G
S
---------
L
G
A
-----
M
M
K
YMK----
T
R
K
F
V
P
-
E
G
V
E
G
V
V
P
Y
R
G
T
V
S
E
V
L
Y
Q
L
V
G
G
L
K
A
G
M
G
Y
V
G
A
R
N
I
-
R
E
L
-
K
E
K
G
E
F
V
I
I
-
T
-
H
A
G
I
K
E
S
H
P
62
PsiBlast_CBE
55.95
39%
-91
- C1 -
3TSD
1
?
B:
[235-480]
--------------------------------------------------------------------------------------------------------------------------------
P
-----
N
S
A
K
D
K
-----------------------------------------
Q
------------------------------
G
---------------------------
R
-
L
L
--------------------------------------------------------------------------------------------------
V
G
A
A
--------------
V
--
G
V
T
A
D
A
M
T
R
I
D
A
L
V
K
A
S
V
--
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
P
S
L
N
I
I
A
G
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
--
P
Q
L
T
A
V
Y
D
C
A
T
E
A
---
R
K
H
G
I
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
------
G
R
Q
F
K
V
Y
--
R
G
M
--------------------------------------
I
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
-
E
F
L
-
R
E
N
-
A
Q
F
I
R
-
M
-
S
G
A
G
L
L
E
S
H
13
PsiBlast_PDB
54.66
39%
-90
- C1 -
3TSD
1
?
A:
[235-480]
--------------------------------------------------------------------------------------------------------------------------------
P
-----
N
S
A
K
D
K
-----------------------------------------
Q
------------------------------
G
---------------------------
R
-
L
L
--------------------------------------------------------------------------------------------------
V
G
A
A
--------------
V
--
G
V
T
A
D
A
M
T
R
I
D
A
L
V
K
A
S
V
--
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
P
S
L
N
I
I
A
G
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
--
P
Q
L
T
A
V
Y
D
C
A
T
E
A
---
R
K
H
G
I
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
-------
R
Q
F
K
V
Y
--
R
G
----------------------------------------
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
-
E
F
L
-
R
E
N
-
A
Q
F
I
R
-
M
-
S
G
A
G
L
L
E
S
H
18
PsiBlast_PDB
53.21
39%
-88
- C1 -
3USB
3
?
A:
[235-480]
--------------------------------------------------------------------------------------------------------------------------------
P
-----
N
S
A
K
D
K
-----------------------------------------
Q
------------------------------
G
---------------------------
R
-
L
L
--------------------------------------------------------------------------------------------------
V
G
A
A
--------------
V
--
G
V
T
A
D
A
M
T
R
I
D
A
L
V
K
A
S
V
--
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
P
S
L
N
I
I
A
G
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
--
P
Q
L
T
A
V
Y
D
C
A
T
E
A
---
R
K
H
G
I
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
-
E
I
Y
Q
G
R
Q
F
K
V
------------------------------------------------
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
-
E
F
L
-
R
E
N
-
A
Q
F
I
R
-
M
-
S
G
A
G
L
L
---