@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_0792: (2015-12-18 )
MKKILVIGDLIADYYLWGKSERLSPEAPVPVLEVKKESKNLGGAANVANNLTSLKAKVFLCGVVGDDLEGKHFISTLKTRGIDTSGVLIDKTRCTTLKTRIIAQNQQIVRVDKEIKDPLNADLRKNLLDFIAEKIQEIDGVILSDYNKGVLDFELTQTIITLANKHHKLILCDPKGKDYSKYSHASLITPNRAELEQALHLKLDSHANLSKALQILQETYHIAMPLVTLSEQGIAFLEKGELVNCPTIAKEVYDVTGAGDTVIASLTLSLLESKSLKEACEFANAAAAVVVGKMGSALASLEEIALILNQTHPKILPLEKLLETLERNQQKIVFTNGCFDILHKGHASYLQKAKALGDILVVGLNSDNSIKRLKGDKRPIVSEKDRAFLLASLSCVDYVVVFGEDTPIKLIQALKPDILVKGADYLNKEVIGSELAKETRLIEFEEGYSTSAIIEKIKRTHND
Atome Classification :
(20 SA)
----------.........10........20........30...-.....40..-......50.....-...60........70........80........90.......-.100.-.-.....110........120.......130.......--140.......150.......160.......170.....---.-----.---180----------.-.-......190.......200...-.--...210.......220.......230.......240.........250.......260.......270--.-......280.......290..--...--.--.300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----------M
K
K
I
L
V
I
G
D
L
I
A
D
Y
Y
LWGKSERLSPEAPV
P
V
L
E
V
-
K
K
ESKNLGG-
A
A
N
V
A
N
N
L
T
S
L
K
A
-
K
V
F
L
C
GVVGDDLEG
K
H
F
I
S
T
L
K
TRGIDTS
G
V
L
I
DKTR
C
T
T
L
K
-
T
R
I
I
A-Q-N
Q
Q
I
V
R
V
-
D
K
E
IKDP
L
N
A
D
L
R
K
N
L
L
D
F
I
A
E
K
I
Q
E
ID--
G
V
I
LSDYNKGVL
D
F
E
L
T
Q
T
I
I
T
L
ANKH
H
K
L
I
L
CDPKGK---D-----Y---SK-----------Y-S-HASLITP
N
R
A
E
L
E
Q
A
L
H
LKLDS-H--A
N
L
S
K
A
L
Q
I
L
Q
E
T
Y
H
IA
M
P
L
V
TLSEQG
I
A
F
LEKG--ELVNC
P
T
I
A
K
E
V
Y
DVTGAG
D
T
V
I
A
S
L
T
L
S
L
L
E
--
S
-
K
S
L
K
E
A
C
E
F
A
N
A
A
A
A
V
V
V
G
K
M
--
G
S
A
--
L
--
A
S
L
E
E
I
A
L
I
L
NQTHPKIL
P
L
E
K
L
L
E
T
L
ERNQ
Q
K
I
V
FTN
G
C
F
D
I
L
HKG
H
A
S
Y
L
Q
K
A
K
ALG
D
I
L
V
V
GLNSDN
S
I
K
R
LKGDKRPIVSEKD
R
A
F
L
L
A
S
L
S
C
V
D
Y
V
V
V
FGED
T
P
I
K
L
I
Q
ALKP
D
I
L
V
K
G
A
D
Y
L
N
K
E
V
I
G
S
E
L
A
K
ET
R
L
I
E
F
EEGY
S
T
S
A
I
I
E
K
I
K
R
THND
51
Fugue
96.22
39%
-94
- C1 -
4E8Y
4
?
A:
[43-350]
VVPVP
R
E
Q
L
A
R
S
R
V
L
V
V
G
D
V
M
L
D
R
Y
W
F
G
N
V
D
R
I
S
P
E
A
P
V
P
V
V
H
V
-
Q
R
Q
E
E
R
L
G
G
-
A
A
N
V
A
R
N
A
V
T
L
G
G
-
Q
A
G
L
L
C
V
V
G
C
D
E
P
G
E
R
I
V
E
L
L
G
S
S
G
V
-
T
P
H
L
E
R
D
P
A
L
P
T
T
I
K
-
L
R
V
L
A
-
R
-
Q
Q
Q
L
L
R
V
-
D
F
E
--
A
M
P
T
H
E
V
L
L
A
G
L
A
R
F
D
V
L
L
P
Q
H
D
--
V
V
L
M
S
D
Y
A
K
G
G
L
T
H
--
V
T
T
M
I
E
K
A
R
A
A
G
K
A
V
L
V
D
P
K
G
D
---
D
-----
W
---
A
R
-----------
Y
-
R
-
G
A
S
L
I
T
P
N
R
A
E
L
R
E
V
V
G
-
Q
W
K
S
-
E
--
D
D
L
R
A
R
V
A
N
L
R
A
E
L
D
I
D
A
L
L
L
T
R
S
E
E
G
M
T
L
F
S
A
G
--
G
E
L
H
A
P
A
L
A
R
E
V
F
D
V
S
G
A
G
D
T
V
I
A
T
V
A
T
M
L
G
A
--
G
-
V
P
L
V
D
A
V
V
L
A
N
R
A
A
G
I
V
V
G
K
L
--
G
T
A
--
T
--
V
D
Y
D
E
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
92.60
40%
-89
- C1 -
4E8W
2
?
B:
[55-350]
------------
R
V
L
V
V
G
D
V
M
L
D
R
Y
W
F
G
N
V
D
R
I
S
P
E
A
P
V
P
V
V
H
V
-
Q
R
Q
E
E
R
L
G
G
-
A
A
N
V
A
R
N
A
V
T
L
G
G
-
Q
A
G
L
L
C
V
V
G
C
D
E
P
G
E
R
I
V
E
L
L
G
S
S
G
V
-
T
P
H
L
E
R
D
P
A
L
P
T
T
I
K
-
L
R
V
L
A
-
R
-
Q
Q
Q
L
L
R
V
-
D
F
E
A
M
-
P
T
H
E
V
L
L
A
G
L
A
R
F
D
V
L
L
P
Q
H
-
D
--
V
V
L
M
S
D
Y
A
K
G
G
L
T
H
--
V
T
T
M
I
E
K
A
R
A
A
G
K
A
V
L
V
D
P
K
G
D
---
D
-----
W
---
A
R
-----------
Y
-
R
-
G
A
S
L
I
T
P
N
R
A
E
L
R
E
V
V
G
-
Q
W
K
S
-
E
--
D
D
L
R
A
R
V
A
N
L
R
A
E
L
D
I
D
A
L
L
L
T
R
S
E
E
G
M
T
L
F
S
A
G
--
G
E
L
H
A
P
A
L
------
V
S
G
A
G
D
T
V
I
A
T
V
A
T
M
L
G
A
--
G
-
V
P
L
V
D
A
V
V
L
A
N
R
A
A
G
I
V
V
G
K
---
G
T
A
--
T
--
V
D
Y
D
E
L
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
92.03
40%
-84
- C1 -
4E8Y
4
?
B:
[55-350]
------------
R
V
L
V
V
G
D
V
M
L
D
R
Y
W
F
G
N
V
D
R
I
S
P
E
A
P
V
P
V
V
H
V
-
Q
R
Q
E
E
R
L
G
G
-
A
A
N
V
A
R
N
A
V
T
L
G
G
-
Q
A
G
L
L
C
V
V
G
C
D
E
P
G
E
R
I
V
E
L
L
G
S
S
G
V
-
T
P
H
L
E
R
D
P
A
L
P
T
T
I
K
-
L
R
V
L
A
-
R
-
Q
Q
Q
L
L
R
V
-
D
F
E
A
M
-
P
T
H
E
V
L
L
A
G
L
A
R
F
D
V
L
L
P
Q
H
-
D
--
V
V
L
M
S
D
Y
A
K
G
G
L
T
H
--
V
T
T
M
I
E
K
A
R
A
A
G
K
A
V
L
V
D
P
K
G
D
---
D
-----
W
---
A
R
-----------
Y
-
R
-
G
A
S
L
I
T
P
N
R
A
E
L
R
E
V
V
G
-
Q
W
K
S
-
E
--
D
D
L
R
A
R
V
A
N
L
R
A
E
L
D
I
D
A
L
L
L
T
R
S
E
E
G
M
T
L
F
S
A
G
--
G
E
L
H
A
P
A
L
A
R
E
V
F
D
V
S
G
A
G
D
T
V
I
A
T
V
A
T
M
L
G
A
--
G
-
V
P
L
V
D
A
V
V
L
A
N
R
A
A
G
I
V
V
G
K
L
--
G
T
A
--
T
--
V
D
Y
D
E
L
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
91.94
40%
-82
- C1 -
4E8Y
4
?
A:
[55-350]
------------
R
V
L
V
V
G
D
V
M
L
D
R
Y
W
F
G
N
V
D
R
I
S
P
E
A
P
V
P
V
V
H
V
-
Q
R
Q
E
E
R
L
G
G
-
A
A
N
V
A
R
N
A
V
T
L
G
G
-
Q
A
G
L
L
C
V
V
G
C
D
E
P
G
E
R
I
V
E
L
L
G
S
S
G
V
-
T
P
H
L
E
R
D
P
A
L
P
T
T
I
K
-
L
R
V
L
A
-
R
-
Q
Q
Q
L
L
R
V
-
D
F
E
A
M
-
P
T
H
E
V
L
L
A
G
L
A
R
F
D
V
L
L
P
Q
H
-
D
--
V
V
L
M
S
D
Y
A
K
G
G
L
T
H
--
V
T
T
M
I
E
K
A
R
A
A
G
K
A
V
L
V
D
P
K
G
D
---
D
-----
W
---
A
R
-----------
Y
-
R
-
G
A
S
L
I
T
P
N
R
A
E
L
R
E
V
V
G
-
Q
W
K
S
-
E
--
D
D
L
R
A
R
V
A
N
L
R
A
E
L
D
I
D
A
L
L
L
T
R
S
E
E
G
M
T
L
F
S
A
G
--
G
E
L
H
A
P
A
L
A
R
E
V
F
D
V
S
G
A
G
D
T
V
I
A
T
V
A
T
M
L
G
A
--
G
-
V
P
L
V
D
A
V
V
L
A
N
R
A
A
G
I
V
V
G
K
L
--
G
T
A
--
T
--
V
D
Y
D
E
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
91.75
40%
-84
- C1 -
4E84
7
?
A:
[55-350]
------------
R
V
L
V
V
G
D
V
M
L
D
R
Y
W
F
G
N
V
D
R
I
S
P
E
A
P
V
P
V
V
H
V
-
Q
R
Q
E
E
R
L
G
G
-
A
A
N
V
A
R
N
A
V
T
L
G
G
-
Q
A
G
L
L
C
V
V
G
C
D
E
P
G
E
R
I
V
E
L
L
G
S
S
G
V
-
T
P
H
L
E
R
D
P
A
L
P
T
T
I
K
-
L
R
V
L
A
-
R
-
Q
Q
Q
L
L
R
V
-
D
F
E
A
M
-
P
T
H
E
V
L
L
A
G
L
A
R
F
D
V
L
L
P
Q
H
-
D
--
V
V
L
M
S
D
Y
A
K
G
G
L
T
H
--
V
T
T
M
I
E
K
A
R
A
A
G
K
A
V
L
V
D
P
K
G
D
---
D
-----
W
---
A
R
-----------
Y
-
R
-
G
A
S
L
I
T
P
N
R
A
E
L
R
E
V
V
G
-
Q
W
K
S
-
E
--
D
D
L
R
A
R
V
A
N
L
R
A
E
L
D
I
D
A
L
L
L
T
R
S
E
E
G
M
T
L
F
S
A
G
--
G
E
L
H
A
P
A
L
A
R
E
V
F
D
V
S
G
A
G
D
T
V
I
A
T
V
A
T
M
L
G
A
--
G
-
V
P
L
V
D
A
V
V
L
A
N
R
A
A
G
I
V
V
G
K
L
--
G
T
A
--
T
--
V
D
Y
D
E
L
F
H
-------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
91.66
40%
-88
- C1 -
4E8W
2
?
A:
[55-350]
------------
R
V
L
V
V
G
D
V
M
L
D
R
Y
W
F
G
N
V
D
R
I
S
P
E
A
P
V
P
V
V
H
V
-
Q
R
Q
E
E
R
L
G
G
-
A
A
N
V
A
R
N
A
V
T
L
G
G
-
Q
A
G
L
L
C
V
V
G
C
D
E
P
G
E
R
I
V
E
L
L
G
S
S
G
V
-
T
P
H
L
E
R
D
P
A
L
P
T
T
I
K
-
L
R
V
L
A
-
R
-
Q
Q
Q
L
L
R
V
-
D
F
E
A
M
-
P
T
H
E
V
L
L
A
G
L
A
R
F
D
V
L
L
P
Q
H
-
D
--
V
V
L
M
S
D
Y
A
K
G
G
L
T
H
--
V
T
T
M
I
E
K
A
R
A
A
G
K
A
V
L
V
D
P
K
G
D
---
D
-----
W
---
A
R
-----------
Y
-
R
-
G
A
S
L
I
T
P
N
R
A
E
L
R
E
V
V
G
-
Q
W
K
S
-
E
--
D
D
L
R
A
R
V
A
N
L
R
A
E
L
D
I
D
A
L
L
L
T
R
S
E
E
G
M
T
L
F
S
A
G
--
G
E
L
H
A
P
A
L
A
-----
V
S
G
A
G
D
T
V
I
A
T
V
A
T
M
L
G
A
--
G
-
V
P
L
V
D
A
V
V
L
A
N
R
A
A
G
I
V
V
G
K
----
T
A
--
T
--
V
D
Y
D
E
L
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
90.78
40%
-86
- C1 -
4E8Z
2
?
B:
[55-350]
------------
R
V
L
V
V
G
D
V
M
L
D
R
Y
W
F
G
N
V
D
R
I
S
P
E
A
P
V
P
V
V
H
V
-
Q
R
Q
E
E
R
L
G
G
-
A
A
N
V
A
R
N
A
V
T
L
G
G
-
Q
A
G
L
L
C
V
V
G
C
D
E
P
G
E
R
I
V
E
L
L
G
S
S
G
V
-
T
P
H
L
E
R
D
P
A
L
P
T
T
I
K
-
L
R
V
L
A
-
R
-
Q
Q
Q
L
L
R
V
-
D
F
E
A
M
-
P
T
H
E
V
L
L
A
G
L
A
R
F
D
V
L
L
P
Q
H
-
D
--
V
V
L
M
S
D
Y
A
K
G
G
L
T
H
--
V
T
T
M
I
E
K
A
R
A
A
G
K
A
V
L
V
D
P
K
G
D
---
D
-----
W
---
A
R
-----------
Y
-
R
-
G
A
S
L
I
T
P
N
R
A
E
L
R
E
V
V
G
-
Q
W
K
S
-
E
--
D
D
L
R
A
R
V
A
N
L
R
A
E
L
D
I
D
A
L
L
L
T
R
S
E
E
G
M
T
L
F
S
A
G
--
G
E
L
H
A
P
A
L
--
E
V
F
D
V
S
G
A
G
D
T
V
I
A
T
V
A
T
M
L
G
A
--
G
-
V
P
L
V
D
A
V
V
L
A
N
R
A
A
G
I
V
V
G
K
L
--
G
T
A
--
T
--
V
D
Y
D
E
L
F
H
-------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
89.95
40%
-84
- C1 -
4E8Z
2
?
A:
[55-350]
------------
R
V
L
V
V
G
D
V
M
L
D
R
Y
W
F
G
N
V
D
R
I
S
P
E
A
P
V
P
V
V
H
V
-
Q
R
Q
E
E
R
L
G
G
-
A
A
N
V
A
R
N
A
V
T
L
G
G
-
Q
A
G
L
L
C
V
V
G
C
D
E
P
G
E
R
I
V
E
L
L
G
S
S
G
V
-
T
P
H
L
E
R
D
P
A
L
P
T
T
I
K
-
L
R
V
L
A
-
R
-
Q
Q
Q
L
L
R
V
-
D
F
E
A
M
-
P
T
H
E
V
L
L
A
G
L
A
R
F
D
V
L
L
P
Q
H
-
D
--
V
V
L
M
S
D
Y
A
K
G
G
L
T
H
--
V
T
T
M
I
E
K
A
R
A
A
G
K
A
V
L
V
D
P
K
G
D
---
D
-----
W
---
A
R
-----------
Y
-
R
-
G
A
S
L
I
T
P
N
R
A
E
L
R
E
V
V
G
-
Q
W
K
S
-
E
--
D
D
L
R
A
R
V
A
N
L
R
A
E
L
D
I
D
A
L
L
L
T
R
S
E
E
G
M
T
L
F
S
A
G
--
G
E
L
H
A
P
A
L
A
R
E
V
F
D
V
S
G
A
G
D
T
V
I
A
T
V
A
T
M
L
G
A
--
G
-
V
P
L
V
D
A
V
V
L
A
N
R
A
A
G
I
V
V
G
K
L
--
G
T
A
--
T
--
V
D
Y
D
E
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
31
HHSearch
75.30
24%
-85
* C1 *
1RKD
4
RBSK_ECOLI
A:
[4-307]
----------
A
G
S
L
V
V
L
G
S
I
N
A
D
H
I
L
N
L
--
Q
S
F
P
T
P
--
G
E
T
V
T
G
-
N
H
Y
Q
V
A
F
G
G
K
G
A
N
Q
A
V
A
A
G
R
S
G
A
-
N
I
A
F
I
A
C
T
G
D
D
S
I
G
E
S
V
R
Q
Q
L
A
T
D
N
I
D
I
T
P
V
S
V
I
K
G
E
S
T
G
V
A
-
L
I
F
V
N
G
E
-
G
E
N
V
I
G
I
-
H
A
G
A
N
A
A
L
S
P
A
L
V
E
A
----
Q
R
E
R
I
A
N
A
S
--
A
L
L
M
Q
L
E
----
S
P
L
E
S
V
M
A
A
A
K
I
A
H
Q
N
K
T
I
V
A
L
N
P
A
P
A
R
E
-
L
-----
P
D
--
E
L
-----------
L
-
A
-
L
V
D
I
I
T
P
N
E
T
E
A
E
K
L
T
G
I
R
V
E
N
-
D
--
E
D
A
A
K
A
A
Q
V
L
-
H
E
K
G
I
R
T
V
L
I
T
L
G
S
R
G
V
W
A
S
V
N
G
--
E
G
Q
R
V
P
G
F
R
V
Q
A
V
D
T
I
A
A
G
D
T
F
N
G
A
L
I
T
A
L
L
E
--
E
-
K
P
L
P
E
A
I
R
F
A
H
A
A
A
A
I
A
V
T
R
K
--
G
A
Q
PS
V
--
P
W
R
E
E
I
D
A
F
L
D
R
Q
R
-------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
73.12
22%
-63
- C1 -
3PL2
-
?
A:
[10-316]
------------
E
V
L
A
I
G
R
L
G
V
D
I
Y
--------
P
L
Q
S
G
V
G
L
A
D
V
-
Q
S
F
G
K
Y
L
G
G
-
S
A
A
N
V
S
V
A
A
A
R
H
G
H
N
S
A
L
L
S
R
V
G
N
D
P
F
G
E
Y
L
L
A
E
L
E
R
L
G
V
D
N
Q
Y
V
A
T
D
Q
T
F
K
T
P
V
T
F
C
E
I
F
P
-
P
-
D
D
F
P
L
Y
F
-
Y
R
E
P
K
A
P
---
D
L
N
I
E
S
A
D
V
S
L
D
D
V
R
E
A
D
I
L
W
F
T
L
T
G
F
S
E
E
P
S
R
G
T
H
R
E
I
L
T
T
R
A
N
R
R
H
T
I
F
D
L
D
Y
R
P
M
---
F
-----
W
---
E
S
P
E
E
A
T
K
Q
A
E
W
A
L
-
Q
-
H
S
T
V
A
V
G
N
K
E
E
C
E
I
A
V
-----
G
-
E
--
T
E
P
E
R
A
G
R
A
L
L
E
R
-
G
V
E
L
A
I
V
K
Q
G
P
K
G
V
M
A
M
T
K
D
--
E
T
V
E
V
P
P
F
F
V
D
V
I
N
G
L
G
A
G
D
A
F
G
G
A
L
C
H
G
L
L
S
--
E
-
W
P
L
E
K
V
L
R
F
A
N
T
A
G
A
L
V
A
S
R
L
EC
S
T
A
--
M
--
P
T
T
D
E
V
E
A
S
L
N
----------------------------------------------------------------------------------------------------------------------------------------------------------
35
HHSearch
73.10
18%
-90
- C1 -
3KZH
1
?
A:
[6-309]
----------
E
P
Y
L
L
V
F
G
A
S
V
V
D
V
F
G
F
S
K
--
A
S
Y
R
P
Y
N
---
S
T
P
-
G
H
V
K
I
S
F
G
G
V
C
R
N
I
A
E
N
M
A
R
V
G
V
-
N
T
N
F
M
S
I
L
G
N
D
E
H
G
K
S
I
V
E
H
S
K
K
I
G
Y
H
M
D
D
S
M
V
I
E
G
G
S
T
P
T
Y
-
L
A
I
L
D
E
N
-
G
E
M
V
S
A
I
A
D
M
K
S
I
G
A
M
N
T
D
F
----
I
D
S
K
R
E
I
F
E
N
A
E
--
Y
T
V
L
D
S
D
N
-----
P
E
I
M
E
Y
L
L
K
N
F
K
-
D
K
T
N
F
I
L
D
P
V
S
A
---
E
K
A
S
W
V
K
---
H
L
-----------
I
-
K
-
D
F
H
T
I
K
P
N
R
H
E
A
E
I
L
A
G
F
P
I
T
D
-
T
--
D
D
L
I
K
A
S
N
Y
F
L
-
G
L
G
I
K
K
V
F
I
S
L
D
A
D
G
I
F
Y
N
D
G
V
--
S
C
G
K
I
K
A
T
E
V
D
V
K
N
V
T
G
A
G
D
S
F
V
A
G
L
G
Y
G
Y
M
N
--
K
-
M
P
I
E
D
I
V
K
F
A
M
T
M
S
N
I
T
I
S
H
E
--
E
T
I
--
H
PD
M
A
L
D
T
V
L
A
K
L
E
K
T
T
W
E
E
E
K
Y
D
L
-----------------------------------------------------------------------------------------------------------------------------------------------
36
HHSearch
73.04
21%
-77
- C1 -
2RBC
12
?
A:
[29-328]
----------
G
K
H
V
L
C
V
G
A
A
V
L
D
T
L
F
R
V
A
--
D
M
P
K
G
E
--
G
K
V
L
P
-
Y
E
V
L
Q
I
A
E
G
M
A
S
S
A
A
Y
A
V
H
R
M
G
G
-
R
A
S
L
W
G
A
V
G
D
D
E
T
G
T
R
I
L
R
D
L
S
E
S
G
I
D
T
S
G
M
T
V
A
P
G
A
R
S
A
L
S
-
T
I
I
I
D
N
R
-
G
E
R
L
I
V
P
-
F
Y
D
H
R
L
H
E
K
K
R
---
A
C
T
---
P
E
D
I
A
L
F
D
--
A
V
L
V
D
V
R
W
-----
P
E
L
A
L
D
V
L
T
V
A
R
A
L
G
K
P
A
I
L
D
G
D
V
A
---
P
V
E
T
L
-
E
---
G
L
-----------
A
-
P
-
A
A
T
H
I
V
F
S
E
P
A
A
T
R
L
T
G
L
E
T
--------
V
K
D
M
L
P
V
L
H
A
R
Y
P
Q
T
F
I
A
V
T
A
G
P
A
G
C
W
W
T
E
A
D
DP
T
V
H
F
Q
T
T
M
Q
V
E
A
V
D
T
L
A
A
G
D
I
F
H
G
T
F
A
L
A
M
A
E
--
G
-
M
Q
S
R
A
A
V
R
L
S
S
V
A
A
A
L
K
C
T
V
F
--
G
G
R
IG
A
--
P
T
R
E
E
T
E
E
A
M
R
Q
W
L
E
R
E
----------------------------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
72.04
23%
-78
- C1 -
2FV7
8
RBSK_HUMAN
A:
[24-330]
----------
V
A
A
V
V
V
V
G
S
C
M
T
D
L
V
S
L
T
--
S
R
L
P
K
T
G
--
E
T
I
H
G
-
H
K
F
F
I
G
F
G
G
K
G
A
N
Q
C
V
Q
A
A
R
L
G
A
-
M
T
S
M
V
C
K
V
G
K
D
S
F
G
N
D
Y
I
E
N
L
K
Q
N
D
I
S
T
E
F
T
Y
Q
T
K
D
A
A
T
G
T
A
-
S
I
I
V
N
N
E
-
G
Q
N
I
I
V
I
-
V
A
G
A
N
L
L
L
N
T
E
D
L
R
A
----
A
A
N
V
I
S
R
A
K
--
V
M
V
C
Q
L
E
----
I
T
P
A
T
S
L
E
A
L
T
M
A
R
R
S
G
V
K
T
L
F
N
P
A
P
A
---
I
ADLD-
P
---
Q
F
-----------
Y
-
T
-
L
S
D
V
F
C
C
N
E
S
E
A
E
I
L
T
G
L
T
V
G
S
-
A
--
A
D
A
G
E
A
A
L
V
L
L
-
K
R
G
C
Q
V
V
I
I
T
L
G
A
E
G
C
V
V
L
S
Q
T
EP
E
P
K
H
I
P
T
E
K
V
K
A
V
D
T
T
G
A
G
D
S
F
V
G
A
L
A
F
Y
L
A
Y
YP
N
-
L
S
L
E
D
M
L
N
R
S
N
F
I
A
A
V
S
V
Q
A
A
--
G
T
Q
--
S
SY
P
Y
K
K
D
L
P
L
T
L
F
----------------------------------------------------------------------------------------------------------------------------------------------------------
34
HHSearch
71.06
20%
-81
- C1 -
3IE7
3
?
A:
[2-303]
----------
S
L
I
Y
T
I
T
L
N
P
A
I
D
R
L
L
F
I
R
--
G
E
L
E
K
--
R
K
T
N
R
V
-
I
K
T
E
F
D
C
G
G
K
G
L
H
V
S
G
V
L
S
K
F
G
I
-
K
N
E
A
L
G
I
A
G
S
D
N
L
-
D
K
L
Y
A
I
L
K
E
K
H
I
N
H
D
F
L
V
E
-
A
G
T
S
T
R
E
C
-
F
V
V
L
S
D
D
T
N
G
S
T
M
I
P
-
E
A
G
F
--
T
V
S
Q
T
N
K
D
N
L
L
K
Q
I
A
K
K
V
K
K
E
D
--
M
V
V
I
A
G
S
P
P
P
H
Y
T
L
S
D
F
K
E
L
L
R
T
V
K
A
T
G
A
F
L
G
C
D
N
S
G
E
---
Y
-----
L
N
--
L
A
-----------
V
E
M
-
G
V
D
F
I
K
P
N
E
D
E
V
I
A
I
L
D
E
K
T
N
S
------
L
E
E
N
I
R
T
L
A
E
--
K
I
P
Y
L
V
V
S
L
G
A
K
G
S
I
C
A
H
N
G
--
K
L
Y
Q
V
I
P
P
K
V
Q
E
R
N
D
T
G
A
G
D
V
F
V
G
A
F
I
A
G
L
A
M
--
N
-
M
P
I
T
E
T
L
K
V
A
T
G
C
S
A
S
K
V
M
Q
Q
--
D
S
S
--
S
--
F
D
L
E
A
A
G
K
L
K
N
Q
V
S
I
I
Q
L
E
--------------------------------------------------------------------------------------------------------------------------------------------------
32
HHSearch
69.47
20%
-81
- C1 -
2F02
1
LACC_ENTFA
A:
[2-307]
----------
S
L
I
V
T
V
T
M
N
P
S
I
D
I
S
Y
L
L
--
D
H
L
K
L
D
---
T
V
N
R
T
-
S
Q
V
T
K
T
P
G
G
K
G
L
N
V
T
R
V
I
H
D
L
G
G
-
D
V
I
A
T
G
V
L
G
G
-
F
H
G
A
F
I
A
N
E
L
K
K
A
N
I
P
Q
A
F
T
S
I
--
K
E
E
T
R
D
S
-
I
A
I
L
H
-
E
-
G
N
Q
T
E
I
L
-
E
A
G
P
--
T
V
S
P
E
E
I
S
N
F
L
E
N
F
D
Q
L
I
K
Q
A
E
--
I
V
T
I
S
G
S
L
A
K
G
L
P
S
D
F
Y
Q
E
L
V
Q
K
A
H
A
Q
E
V
K
V
L
L
D
T
S
G
D
---
S
L
R
Q
V
-
L
---
Q
G
-----------
P
-
W
-
K
P
Y
L
I
K
P
N
L
E
E
L
E
G
L
L
G
Q
D
F
S
E
-
N
P
L
A
A
V
Q
T
A
L
T
K
P
M
-
F
A
G
I
E
W
I
V
I
S
L
G
K
D
G
A
I
A
K
H
H
D
--
Q
F
Y
R
V
K
I
P
T
I
Q
A
K
N
P
V
G
S
G
D
A
T
I
A
G
L
A
Y
G
L
A
K
--
D
-
A
P
A
A
E
L
L
K
W
G
M
A
A
G
M
A
N
A
Q
E
R
--
M
T
G
--
H
--
V
D
V
E
N
V
K
K
H
L
M
N
I
Q
V
V
E
I
A
K
E
G
H
H
H
--------------------------------------------------------------------------------------------------------------------------------------------
44
HHSearch
69.30
21%
-75
- C1 -
2ABQ
3
?
A:
[1-297]
-----------
M
I
Y
T
V
T
L
N
P
S
I
D
Y
I
V
Q
V
--
E
N
F
Q
Q
G
---
V
V
N
R
S
-
E
R
D
R
K
Q
P
G
G
K
G
I
N
V
S
R
V
L
K
R
L
G
H
-
E
T
K
A
L
G
F
L
G
G
-
F
T
G
A
Y
V
R
N
A
L
E
K
E
E
I
G
L
S
F
I
E
V
--
E
G
D
T
R
I
N
-
V
K
I
K
G
-
K
-
Q
E
T
E
L
---
N
-
G
T
A
P
L
I
K
K
E
H
V
Q
A
L
L
E
Q
L
-
T
E
L
E
K
G
D
--
V
L
V
L
A
G
S
V
P
Q
A
M
P
Q
T
I
Y
R
S
M
T
Q
I
A
K
E
R
G
A
F
V
A
V
D
T
S
G
E
A
--
L
-----
H
---
E
V
-----------
L
A
A
-
K
P
S
F
I
K
P
N
H
H
E
L
S
E
L
V
S
K
P
I
A
S
-
I
--
E
D
A
I
P
H
V
Q
R
L
I
-
G
E
G
I
E
S
I
L
V
S
F
A
G
D
G
A
L
F
A
S
A
E
--
G
M
F
H
V
N
V
P
S
G
E
V
R
N
S
V
G
A
G
D
S
V
V
A
G
F
L
A
A
L
Q
E
--
G
-
K
S
L
E
D
A
V
P
F
A
V
A
A
G
S
A
T
A
F
S
D
--
G
F
------
C
T
R
E
E
V
E
R
L
Q
Q
Q
L
Q
R
T
I
K
K
E
G
------------------------------------------------------------------------------------------------------------------------------------------------
42
HHSearch
68.51
20%
-84
- C1 -
3UMO
7
PFKB_ECOLI
A:
[3-306]
-----------
R
I
Y
T
L
T
L
A
P
S
L
D
S
A
T
I
T
--
P
Q
I
Y
P
E
---
G
K
L
R
C
-
T
A
P
V
F
E
P
G
G
G
G
I
N
V
A
R
A
I
A
H
L
G
G
-
S
A
T
A
I
F
P
A
G
-
G
A
T
G
E
H
L
V
S
L
L
A
D
E
N
V
P
V
A
T
V
E
A
K
-
D
W
T
R
Q
N
L
-
H
V
H
V
E
A
S
-
G
E
Q
Y
R
F
V
-
M
P
G
A
--
A
L
N
E
D
E
F
R
Q
L
E
E
Q
V
-
L
E
I
E
S
G
A
--
I
L
V
I
S
G
S
L
P
P
G
V
K
L
E
K
L
T
Q
L
I
S
A
A
Q
K
Q
G
I
R
C
I
V
D
S
S
G
E
---
A
-----
L
S
A
A
L
A
-----------
I
-
G
-
N
I
E
L
V
K
P
N
Q
K
E
L
S
A
L
V
N
R
E
L
T
Q
-
P
--
D
D
V
R
K
A
A
Q
E
I
V
N
S
G
K
A
K
R
V
V
V
S
L
G
P
Q
G
A
L
G
V
D
S
E
--
N
C
I
Q
V
V
P
P
P
V
K
S
Q
S
T
V
G
A
G
D
S
M
V
G
A
M
T
L
K
L
A
E
--
N
-
A
S
L
E
E
M
V
R
F
G
V
A
A
G
S
A
A
T
L
N
Q
--
G
T
R
--
L
--
C
S
H
D
D
T
Q
K
I
Y
A
Y
L
S
R
------------------------------------------------------------------------------------------------------------------------------------------------------
38
HHSearch
67.65
23%
-80
- C1 -
3RY7
2
?
A:
[2-302]
----------
T
N
K
V
V
I
L
G
S
T
N
V
D
Q
F
L
T
V
--
E
R
Y
A
Q
P
G
--
E
T
L
H
V
E
E
A
Q
K
A
F
G
G
G
K
G
A
N
Q
A
I
A
T
A
R
M
Q
A
-
D
T
T
F
I
T
K
I
G
T
D
G
V
A
D
F
I
L
E
D
F
K
V
A
H
I
D
T
S
Y
I
I
K
T
A
E
A
K
T
G
Q
A
-
F
I
T
V
N
A
E
-
G
Q
N
T
I
Y
V
-
Y
G
G
A
N
M
T
M
T
P
E
D
V
I
N
----
A
K
D
A
I
I
N
A
D
--
F
V
V
A
Q
L
E
----
V
P
I
P
A
I
I
S
A
F
E
I
A
K
A
H
G
V
T
T
V
L
N
P
A
P
A
K
A
L
P
-----
N
---
E
L
-----------
L
-
S
-
L
I
D
I
I
V
P
N
E
T
E
A
E
L
L
S
G
I
K
V
T
N
-
E
--
Q
S
M
K
D
N
A
N
Y
F
L
-
S
I
G
I
K
T
V
L
I
T
L
G
K
Q
G
T
Y
F
A
T
K
N
--
Q
S
Q
H
I
E
A
Y
K
V
N
A
I
D
T
T
A
A
G
D
T
F
I
G
A
F
V
S
R
L
N
K
--
S
Q
D
N
L
A
D
A
I
D
F
G
N
K
A
S
S
L
T
V
Q
K
H
--
G
A
Q
--
A
SI
P
L
L
E
E
V
N
Q
V
------------------------------------------------------------------------------------------------------------------------------------------------------------
47
HHSearch
67.10
20%
-93
- C1 -
2JG5
-
?
A:
[3-297]
-------------
Y
T
V
T
F
N
P
S
I
D
Y
V
I
F
T
--
N
D
F
K
I
D
G
---
L
N
R
A
-
T
A
T
Y
K
F
A
G
G
K
G
I
N
V
S
R
V
L
K
T
L
D
V
-
E
S
T
A
L
G
F
A
G
G
-
F
P
G
K
F
I
I
D
T
L
N
N
S
A
I
Q
S
N
F
I
E
V
D
--
E
D
T
R
I
N
-
V
K
L
K
--
T
-
G
Q
E
T
E
I
N
-
A
P
G
P
--
H
I
T
S
T
Q
F
E
Q
L
L
Q
Q
I
K
-
N
T
T
S
E
D
--
I
V
I
V
A
G
S
V
P
S
S
I
P
S
D
A
Y
A
Q
I
A
Q
I
T
A
Q
T
G
A
K
L
V
V
D
A
E
K
E
---
L
-----
A
E
--
S
V
-----------
L
-
P
Y
H
P
L
F
I
K
P
N
K
D
E
L
E
V
M
F
N
T
T
V
N
S
-
D
--
A
D
V
I
K
Y
G
R
L
L
V
-
D
K
G
A
Q
S
V
I
V
S
L
G
G
D
G
A
I
Y
I
D
K
E
--
I
S
I
K
A
V
N
P
Q
G
K
V
V
N
T
V
G
S
G
D
S
T
V
A
G
M
V
A
G
I
A
S
--
G
-
L
S
I
E
K
A
F
Q
Q
A
V
A
C
G
T
A
T
A
F
D
E
--
D
----
L
--
A
T
R
D
A
I
E
K
I
K
S
Q
V
T
I
S
V
L
D
G
E
------------------------------------------------------------------------------------------------------------------------------------------------
41
HHSearch
65.99
19%
-82
- C1 -
2JG1
2
LACC_STAA8
A:
[21-324]
-----------
M
I
L
T
L
T
L
N
P
S
V
D
I
S
Y
P
L
--
T
A
L
K
L
D
---
D
V
N
R
V
-
Q
E
V
S
K
T
A
G
G
K
G
L
N
V
T
R
V
L
A
Q
V
G
E
-
P
V
L
A
S
G
F
I
G
G
E
-
L
G
Q
F
I
A
K
K
L
D
H
A
D
I
K
H
A
F
Y
N
I
--
K
G
E
T
R
N
C
-
I
A
I
L
H
-
E
-
G
Q
Q
T
E
I
L
-
E
Q
G
P
E
--
I
D
N
Q
E
A
A
G
F
I
K
H
F
E
Q
M
M
E
K
V
E
--
A
V
A
I
S
G
S
L
P
K
G
L
N
Q
D
Y
Y
A
Q
I
I
E
R
C
Q
N
K
G
V
P
V
I
L
D
C
S
G
A
---
T
L
Q
T
V
-
L
---
E
N
-----------
P
-
Y
-
K
P
T
V
I
K
P
N
I
S
E
L
Y
Q
L
L
N
Q
P
L
D
E
S
L
--
E
S
L
K
Q
A
V
S
Q
P
L
-
F
E
G
I
E
W
I
I
V
S
L
G
A
Q
G
A
F
A
K
H
N
H
--
T
F
Y
R
V
N
I
P
T
I
S
V
L
N
P
V
G
S
G
D
S
T
V
A
G
I
T
S
A
I
L
N
--
H
-
E
N
D
H
D
L
L
K
K
A
N
T
L
G
M
L
N
A
Q
E
A
--
Q
T
G
--
Y
--
V
N
L
N
N
Y
D
D
L
F
N
Q
I
E
V
L
E
V
---------------------------------------------------------------------------------------------------------------------------------------------------