@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_0793: (2015-12-18 )
MRYIDDGLENQTILITGGAGFVGSNLAFYFQENHPKAKVVVLDKFRSNTLSSNNRPSSLGHFKNLIGFKGEVIIADINNPLDLRRLEKLHFDYLFHQAAVSDTTMLNQELVMKTNYQAFLNLLEIARSKKAKVIYASSAGVYGNTKAPNIVGSNESPENVYGFSKLCMDEFVLSHSSDNVVGLRYFNVYGSREFYKEKTASMVLQLALSAMAFKEVKLFEFGEQLRDFVYIEDVIQANVKAMKAQKSGVYNVGYSQARSYNEIVSILKEHLGDFKVSYIKNPYTFFQKHTQAHIEPTILDLDYTPLYDLESGIKDYLPHIHAIFKEQHA
Atome Classification :
(20 SA)
.........10........20........30......------..40........50........60....-....70........---80-.-----......----.-90-.........100.--..---....110.......120.......130-.-.......140.....-----.----------------.150----.-------.-.....160.......170---....----.--.---.180........190....------.-----..200.......210--.--.--......------220----.....-....230.......240..-----.---...---.250...--.-...260.......270..-...-..280.-------..---..----..290.......300..-...-..310.......320.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MRYIDDGLEN
Q
T
I
L
I
TGGAGFVGS
N
L
A
F
Y
F
QENHPK
A
------
K
V
V
V
L
DKFRSNTLSSNNRPS
S
L
G
H
F
K
N
L
-IGFKG
E
V
I
I
A
DINN---
P
L
-
D
-----
L
R
R
L
E
K
----
L
-
H
--
F
D
Y
L
F
H
Q
AAVSD
T
--
T
M---L
N
Q
E
L
V
MKT
N
Y
Q
A
F
L
N
L
L
E
I
A
RSKK-
A
-
K
-
V
I
Y
A
SSAGVYGNTKA-----P----------------NIVG----S-------N-ESP
E
N
V
Y
G
F
S
K
L
C
M
D
E
F
V
---LSHS----S--D---
N
V
-
V
G
L
R
Y
F
N
VYGS
R
E
F
Y
K
------
E
-----
K
T
A
S
M
V
L
Q
L
A
L
S
A
M
---
A
--
F
--
K
E
V
K
L
F
------
E
------
F
G
E
Q
L
-
R
D
F
V
Y
I
E
D
V
I
Q
A
N
V
K
A
M
K
A-----Q---KSG---VYNVG
Y
S
--
Q
-AR
S
Y
N
E
I
V
S
I
L
K
E
H
L
G
D
F
-
K
V
S
-
Y
IK
N
P
Y
-------
T
F
---
F
Q
----
K
H
T
Q
AHIE
P
T
I
L
DLDYT-
P
L
Y
-
D
L
E
S
G
I
K
D
Y
L
P
H
I
H
A
I
F
K
EQHA
1
PsiBlast_PDB
97.59
95%
-104
- C1 -
3SXP
1
?
A:
[1-324]
M
R
Y
I
D
D
E
L
E
N
Q
T
I
L
I
T
G
G
A
G
F
V
G
S
N
L
A
F
H
F
Q
E
N
H
P
K
A
------
K
V
V
V
L
D
K
F
R
S
N
-------
P
S
S
L
G
H
F
K
N
L
-
I
G
F
K
G
E
V
I
A
A
D
I
N
N
---
P
L
-
D
-----
L
R
R
L
E
K
----
L
-
H
--
F
D
Y
L
F
H
Q
A
A
V
S
D
T
--
T
M
---
L
N
Q
E
L
V
M
K
T
N
Y
Q
A
F
L
N
L
L
E
I
A
R
S
K
K
-
A
-
K
-
V
I
Y
A
S
S
A
G
V
Y
G
N
T
K
A
-----
P
----------------
N
V
V
G
----
K
-------
N
-
E
S
P
E
N
V
Y
G
F
S
K
L
C
M
D
E
F
V
---
L
S
H
S
----
N
--
D
---
N
V
Q
V
G
L
R
Y
F
N
V
Y
G
P
R
E
F
Y
K
------
E
-----
K
T
A
S
M
V
L
Q
L
A
L
G
A
M
---
A
--
F
--
K
E
V
K
L
F
------
E
------
F
G
E
Q
L
-
R
D
F
V
Y
I
E
D
V
I
Q
A
N
V
K
A
M
K
A
-----
Q
---
K
S
G
---
V
Y
N
V
G
Y
S
--
Q
-
A
R
S
Y
N
E
I
V
S
I
L
K
E
H
L
G
D
F
-
K
V
T
-
Y
I
K
---------------------
K
H
T
Q
A
H
I
E
P
T
I
L
D
L
D
Y
T
-
P
L
Y
-
D
L
E
S
G
I
K
D
Y
L
P
H
I
H
A
I
------
23
PsiBlast_CBE
97.45
95%
-103
- C1 -
3SXP
1
?
C:
[1-324]
M
R
Y
I
D
D
E
L
E
N
Q
T
I
L
I
T
G
G
A
G
F
V
G
S
N
L
A
F
H
F
Q
E
N
H
P
K
A
------
K
V
V
V
L
D
K
F
R
S
N
-------
P
S
S
L
G
H
F
K
N
L
-
I
G
F
K
G
E
V
I
A
A
D
I
N
N
---
P
L
-
D
-----
L
R
R
L
E
K
----
L
-
H
--
F
D
Y
L
F
H
Q
A
A
V
S
D
T
--
T
M
---
L
N
Q
E
L
V
M
K
T
N
Y
Q
A
F
L
N
L
L
E
I
A
R
S
K
K
-
A
-
K
-
V
I
Y
A
S
S
A
G
V
Y
G
N
T
K
A
-----
P
----------------
N
V
V
G
----
K
-------
N
-
E
S
P
E
N
V
Y
G
F
S
K
L
C
M
D
E
F
V
---
L
S
H
S
----
N
--
D
---
N
V
Q
V
G
L
R
Y
F
N
V
Y
G
P
R
E
F
Y
K
------
E
-----
K
T
A
S
M
V
L
Q
L
A
L
G
A
M
---
A
--
F
--
K
E
V
K
L
F
------
E
------
F
G
E
Q
L
-
R
D
F
V
Y
I
E
D
V
I
Q
A
N
V
K
A
M
K
A
-----
Q
---
K
S
G
---
V
Y
N
V
G
Y
S
--
Q
-
A
R
S
Y
N
E
I
V
S
I
L
K
E
H
L
G
D
F
-
K
V
T
-
Y
I
K
---------------------
K
H
T
Q
A
H
I
E
P
T
I
L
D
L
D
Y
T
-
P
L
Y
-
D
L
E
S
G
I
K
D
Y
L
P
H
I
H
A
I
------
24
PsiBlast_CBE
97.02
95%
-104
- C1 -
3SXP
1
?
B:
[1-324]
M
R
Y
I
D
D
E
L
E
N
Q
T
I
L
I
T
G
G
A
G
F
V
G
S
N
L
A
F
H
F
Q
E
N
H
P
K
A
------
K
V
V
V
L
D
K
F
R
S
N
-------
P
S
S
L
G
H
F
K
N
L
-
I
G
F
K
G
E
V
I
A
A
D
I
N
N
---
P
L
-
D
-----
L
R
R
L
E
K
----
L
-
H
--
F
D
Y
L
F
H
Q
A
A
V
S
D
T
--
T
M
---
L
N
Q
E
L
V
M
K
T
N
Y
Q
A
F
L
N
L
L
E
I
A
R
S
K
K
-
A
-
K
-
V
I
Y
A
S
S
A
G
V
Y
G
N
T
K
A
-----
P
----------------
N
V
V
G
----
K
-------
N
-
E
S
P
E
N
V
Y
G
F
S
K
L
C
M
D
E
F
V
---
L
S
H
S
----
N
--
D
---
N
V
Q
V
G
L
R
Y
F
N
V
Y
G
P
R
E
F
Y
K
------
E
-----
K
T
A
S
M
V
L
Q
L
A
L
G
A
M
---
A
--
F
--
K
E
V
K
L
F
------
E
------
F
G
E
Q
L
-
R
D
F
V
Y
I
E
D
V
I
Q
A
N
V
K
A
M
K
A
-----
Q
---
K
S
G
---
V
Y
N
V
G
Y
S
--
Q
-
A
R
S
Y
N
E
I
V
S
I
L
K
E
H
L
G
D
F
-
K
V
T
-
Y
I
K
----------------
Q
----
K
H
T
Q
A
H
I
E
P
T
I
L
D
L
D
Y
T
-
P
L
Y
-
D
L
E
S
G
I
K
D
Y
L
P
H
I
H
A
I
------
21
PsiBlast_CBE
95.99
95%
-105
- C1 -
3SXP
1
?
E:
[1-324]
M
R
Y
I
D
D
E
L
E
N
Q
T
I
L
I
T
G
G
A
G
F
V
G
S
N
L
A
F
H
F
Q
E
N
H
P
K
A
------
K
V
V
V
L
D
K
F
R
S
N
-------
P
S
S
L
G
H
F
K
N
L
-
I
G
F
K
G
E
V
I
A
A
D
I
N
N
---
P
L
-
D
-----
L
R
R
L
E
K
----
L
-
H
--
F
D
Y
L
F
H
Q
A
A
V
S
D
T
--
T
M
---
L
N
Q
E
L
V
M
K
T
N
Y
Q
A
F
L
N
L
L
E
I
A
R
S
K
K
-
A
-
K
-
V
I
Y
A
S
S
A
G
V
Y
G
N
T
K
A
-----
P
----------------
N
V
V
G
----
K
-------
N
-
E
S
P
E
N
V
Y
G
F
S
K
L
C
M
D
E
F
V
---
L
S
H
S
----
N
--
D
---
N
V
Q
V
G
L
R
Y
F
N
V
Y
G
P
R
E
F
Y
K
------
E
-----
K
T
A
S
M
V
L
Q
L
A
L
G
A
M
---
A
--
F
--
K
E
V
K
L
F
------
E
------
F
G
E
Q
L
-
R
D
F
V
Y
I
E
D
V
I
Q
A
N
V
K
A
M
K
A
-----
Q
---
K
S
G
---
V
Y
N
V
G
Y
S
--
Q
-
A
R
S
Y
N
E
I
V
S
I
L
K
E
H
L
G
D
F
-
K
V
T
-
Y
I
K
---------------------
K
H
T
Q
A
H
I
E
P
T
I
L
D
L
D
Y
T
-
P
L
Y
-
D
L
E
S
G
I
K
D
Y
L
P
H
I
H
A
I
------
22
PsiBlast_CBE
95.90
95%
-104
- C1 -
3SXP
1
?
D:
[1-324]
M
R
Y
I
D
D
E
L
E
N
Q
T
I
L
I
T
G
G
A
G
F
V
G
S
N
L
A
F
H
F
Q
E
N
H
P
K
A
------
K
V
V
V
L
D
K
F
R
S
N
-------
P
S
S
L
G
H
F
K
N
L
-
I
G
F
K
G
E
V
I
A
A
D
I
N
N
---
P
L
-
D
-----
L
R
R
L
E
K
----
L
-
H
--
F
D
Y
L
F
H
Q
A
A
V
S
D
T
--
T
M
---
L
N
Q
E
L
V
M
K
T
N
Y
Q
A
F
L
N
L
L
E
I
A
R
S
K
K
-
A
-
K
-
V
I
Y
A
S
S
A
G
V
Y
G
N
T
K
A
-----
P
----------------
N
V
V
G
----
K
-------
N
-
E
S
P
E
N
V
Y
G
F
S
K
L
C
M
D
E
F
V
---
L
S
H
S
----
N
--
D
---
N
V
Q
V
G
L
R
Y
F
N
V
Y
G
P
R
E
F
Y
K
------
E
-----
K
T
A
S
M
V
L
Q
L
A
L
G
A
M
---
A
--
F
--
K
E
V
K
L
F
------
E
------
F
G
E
Q
L
-
R
D
F
V
Y
I
E
D
V
I
Q
A
N
V
K
A
M
K
A
-----
Q
---
K
S
G
---
V
Y
N
V
G
Y
S
--
Q
-
A
R
S
Y
N
E
I
V
S
I
L
K
E
H
L
G
D
F
-
K
V
T
-
Y
I
K
N
----------
F
---
F
Q
----
K
H
T
Q
A
H
I
E
P
T
I
L
D
L
D
Y
T
-
P
L
Y
-
D
L
E
S
G
I
K
D
Y
L
P
H
I
H
A
I
------
17
PsiBlast_PDB
56.43
26%
-85
- C1 -
3LU1
4
GNE_PLESH
A:
[39-356]
----------
K
T
W
L
I
T
G
V
A
G
F
I
G
S
N
L
L
E
K
L
L
K
L
--
N
Q
------
V
V
I
G
L
D
N
F
------
S
T
G
H
Q
Y
N
L
D
E
V
K
T
L
-
V
S
T
E
Q
W
S
R
F
C
F
I
E
G
---
D
I
R
D
-----
L
T
T
C
E
Q
----
V
-
M
KG
V
D
H
V
L
H
Q
A
A
L
G
S
V
P
R
S
I
---
V
D
P
I
T
T
N
A
T
N
I
T
G
F
L
N
I
L
H
A
A
K
N
A
Q
-
V
-
Q
S
F
T
Y
A
A
S
S
S
T
Y
G
D
H
P
A
L----
P
----------------
K
V
E
E
----
N
-------
I
-
G
N
P
L
S
P
Y
A
V
T
K
Y
V
N
E
I
Y
A
---
Q
V
Y
A
----
R
--
T
YG
F
K
T
-
I
G
L
R
Y
F
N
V
F
G
R
R
Q
D
P
N
------
G
-----
A
Y
A
A
V
I
P
K
W
T
A
A
M
L
---
K
--
G
--
D
D
V
Y
I
N
------
G
------
D
G
E
T
S
-
R
D
F
C
Y
I
D
N
V
I
Q
M
N
I
L
S
A
L
A
-----
K
---
D
S
A
KD
N
I
Y
N
V
A
V
G
--
D
-
R
T
T
L
N
E
L
S
G
Y
I
Y
D
E
L
N
L
I
H
H
I
------
K
Y
-------
R
E
---
F
R
SGDV
R
H
S
Q
A
D
V
T
K
A
I
D
L
L
K
Y
R
-
P
N
I
-
K
I
R
E
G
L
R
L
S
M
P
W
Y
V
R
F
L
K
----
3
PsiBlast_PDB
55.12
29%
-88
- C1 -
2X6T
4
HLDD_ECOLI
A:
[48-354]
-----------
M
I
I
V
T
G
G
A
G
F
I
G
S
N
I
V
K
A
L
N
D
K
G
I
-
T
------
D
I
L
V
V
D
N
L
K
D
G
T
-----------
K
F
V
N
L
-
V
----
D
L
N
I
A
D
Y
M
D
---
K
E
-
D
F
L
I
Q
I
M
A
G
E
E
F
----
G
-
D
--
V
E
A
I
F
H
E
G
A
C
S
S
T
--
T
E
---
W
D
G
K
Y
M
M
D
N
N
Y
Q
Y
S
K
E
L
L
H
Y
C
L
E
R
E
-
I
-
P
-
F
L
Y
A
S
S
A
A
T
Y
G
G
R
T
S
-----
D
----------------
F
I
E
S
----
R
-------
E
Y
E
K
P
L
N
V
F
G
Y
S
K
F
L
F
D
E
Y
V
R
Q
I
L
P
E
A
----
N
--
S
---
Q
I
-
V
G
F
R
Y
F
N
V
Y
G
P
R
E
G
H
K
------
G
-----
S
M
A
S
V
A
F
H
L
N
T
Q
L
N
---
N
--
G
--
E
S
P
K
L
F
------
E
------
G
S
E
N
F
K
R
D
F
V
Y
V
G
D
V
A
D
V
N
L
W
F
L
E
N
-----
G
---
V
S
G
---
I
F
N
L
G
T
G
--
R
-
A
E
S
F
Q
A
V
A
D
A
T
L
A
Y
H
K
K
G
-
Q
I
E
-
Y
I
P
F
P
D
-------
K
L
KGR
Y
Q
----
A
F
T
Q
A
D
L
T
N
L
R
A
A
G
Y
D
K
-
P
F
K
-
T
V
A
E
G
V
T
E
Y
M
A
W
L
N
--------
25
HHSearch
53.79
26%
-82
- C1 -
1ORR
2
RFBE_SALTI
A:
[2-339]
----------
A
K
L
L
I
T
G
G
C
G
F
L
G
S
N
L
A
S
F
A
L
S
Q
--
G
I
------
D
L
I
V
F
D
N
L
S
R
K
G
A
-----
T
---
D
N
L
H
W
L
S
S
L
G
N
F
E
F
V
H
G
D
I
R
N
---
K
N
-
D
-----
V
T
R
L
I
T
----
K
Y
M
--
P
D
S
C
F
H
L
A
G
Q
V
A
M
--
T
T
S
I
-
D
N
P
C
M
D
F
E
I
N
V
G
G
T
L
N
L
L
E
A
V
R
Q
Y
N
S
N
C
N
-
I
I
Y
S
S
T
N
K
V
Y
G
D
L
E
Q
-----
Y
K
Y
N
E
T
ETRYTCVDKPN
G
Y
D
E
ST--
Q
-------
L
--
D
F
H
S
P
Y
G
C
S
K
G
A
A
D
Q
Y
M
---
L
D
Y
A
R
---
I
FG
L
---
N
T
-
V
V
F
R
H
S
S
M
Y
G
G
R
Q
F
A
T
------
Y
------
D
Q
G
W
V
G
W
F
C
Q
K
A
V
E
I
K
N
GI
N
--
K
P
F
T
I
S
------
G
------
N
G
K
Q
V
-
R
D
V
L
H
A
E
D
M
I
S
L
Y
F
T
A
L
A
N
VSK--
I
---
R
G
N
---
A
F
N
I
G
G
T
IV
N
-
S
L
S
L
L
E
L
F
K
L
L
E
D
Y
C
N
-
I
-
D
M
R
-
F
T
N
L
P
V
-------
R
E
S--
D
Q
----
R
V
F
V
A
D
I
K
K
I
T
N
A
I
D
W
S
-
P
K
V
-
S
A
K
D
G
V
Q
K
M
Y
D
W
T
S
S
I
------
4
PsiBlast_PDB
53.57
29%
-89
- C1 -
2X86
3
HLDD_ECO57
A:
[48-354]
-----------
M
I
I
V
T
G
G
A
G
F
I
G
S
N
I
V
K
A
L
N
D
K
G
I
-
T
------
D
I
L
V
V
D
N
L
K
D
G
T
-----------
K
F
V
N
L
-
V
----
D
L
N
I
A
D
Y
M
D
---
K
E
-
D
F
L
I
Q
I
M
A
G
E
E
F
----
G
-
D
--
V
E
A
I
F
H
E
G
A
C
S
S
T
--
T
E
---
W
D
G
K
Y
M
M
D
N
N
Y
Q
Y
S
K
E
L
L
H
Y
C
L
E
R
E
-
I
-
P
-
F
L
Y
A
S
S
A
A
T
Y
G
G
R
T
S
-----
D
----------------
F
I
E
S
----
R
-------
E
Y
E
K
P
L
N
V
F
G
Y
S
K
F
L
F
D
E
Y
V
R
Q
I
L
P
E
A
----
N
--
S
---
Q
I
-
V
G
F
R
Y
F
N
V
Y
G
P
R
E
G
H
K
------
G
-----
S
M
A
S
V
A
F
H
L
N
T
Q
L
N
---
N
--
G
--
E
S
P
K
L
F
------
E
------
G
S
E
N
F
K
R
D
F
V
Y
V
G
D
V
A
D
V
N
L
W
F
L
E
N
-----
G
---
V
S
G
---
I
F
N
L
G
T
G
--
R
-
A
E
S
F
Q
A
V
A
D
A
T
L
A
Y
H
K
K
G
-
Q
I
E
-
Y
I
P
F
P
D
-------
K
L
KGR
Y
Q
----
A
F
T
Q
A
D
L
T
N
L
R
A
A
G
Y
D
K
-
P
F
K
-
T
V
A
E
G
V
T
E
Y
M
A
W
L
N
--------
41
HHSearch
52.96
24%
-88
- C1 -
2C20
2
?
A:
[2-326]
----------
N
S
I
L
I
C
G
G
A
G
Y
I
G
S
H
A
V
K
K
L
V
D
E
--
G
L
------
S
V
V
V
V
D
N
L
Q
T
G
H
-------------
E
D
A
-
I
T
E
G
A
K
F
Y
N
G
D
L
R
D
---
K
A
-
F
-----
L
R
D
V
F
T
----
Q
E
N
--
I
E
A
V
M
H
F
A
A
D
S
L
V
--
G
V
S
M
-
E
K
P
L
Q
Y
Y
N
N
N
V
Y
G
A
L
C
L
L
E
V
M
D
E
F
K
-
V
D
K
-
F
I
F
S
S
T
A
A
T
Y
G
E
V
D
V
-----
D
----------------
L
I
T
E
E
T
--
M
-------
T
--
N
P
T
N
T
Y
G
E
T
K
L
A
I
E
K
M
L
---
H
W
Y
S
Q
A
--
S
N-
L
---
R
Y
-
K
I
F
R
Y
F
N
V
A
G
A
T
P
N
G
I
------
I
GEDHR
P
E
T
H
L
I
P
L
V
L
Q
V
A
L
G--
Q
--
R
--
E
K
I
M
M
F
------
G
DDYNTP
D
G
T
C
I
-
R
D
Y
I
H
V
E
D
L
V
A
A
H
F
L
G
L
K
D
L
Q
N
G-
G
---
E
S
D
---
F
Y
N
L
G
N
G
--
N
-
G
F
S
V
K
E
I
V
D
A
V
R
E
V
T
N
-
H
-
E
I
P
-
A
E
V
A
P
R
-------
R
A
G--
D
P
----
A
R
L
V
A
S
S
Q
K
A
K
E
K
L
G
W
D
-
P
R
Y
V
N
V
K
T
I
I
E
H
A
W
N
W
H
Q
K
Q
P
N
G
Y
E
K
13
PsiBlast_PDB
52.89
26%
-85
- C1 -
3RUD
2
GNE_PLESH
A:
[26-343]
----------
K
T
W
L
I
T
G
V
A
G
F
I
G
S
N
L
L
E
K
L
L
K
L
--
N
Q
------
V
V
I
G
L
D
N
F
------
S
T
G
H
Q
Y
N
L
D
E
V
K
T
L
-
V
S
T
E
Q
W
S
R
F
C
F
I
E
G
---
D
I
R
D
-----
L
T
T
C
E
Q
----
V
-
M
KG
V
D
H
V
L
H
Q
A
A
L
G
S
V
P
R
S
I
---
V
D
P
I
T
T
N
A
T
N
I
T
G
F
L
N
I
L
H
A
A
K
N
A
Q
-
V
-
Q
S
F
T
Y
A
A
S
S
S
T
Y
G
D
H
P
A
L----
P
----------------
K
V
E
E
----
N
-------
I
-
G
N
P
L
S
P
Y
A
V
T
K
Y
V
N
E
I
Y
A
---
Q
V
Y
A
----
R
--
T
YG
F
K
T
-
I
G
L
R
Y
F
N
V
F
G
R
R
Q
D
P
N
------
G
-----
A
Y
A
A
V
I
P
K
W
T
A
A
M
L
---
K
--
G
--
D
D
V
Y
I
N
------
G
------
D
G
E
T
S
-
R
D
F
C
Y
I
D
N
V
I
Q
M
N
I
L
S
A
L
A
-----
K
DSA
K
D
N
---
I
Y
N
V
A
V
G
--
D
-
R
T
T
L
N
E
L
S
G
Y
I
Y
D
E
L
N
L
I
H
H
I
------
K
Y
-------
R
E
---
F
R
S
GDV
R
H
S
Q
A
D
V
T
K
A
I
D
L
L
K
Y
R
-
P
N
I
-
K
I
R
E
G
L
R
L
S
M
P
W
Y
V
R
F
L
K
----
34
HHSearch
52.85
30%
-90
- C1 -
1EQ2
2
HLDD_ECOLI
A:
[1-307]
-----------
M
I
I
V
T
G
G
A
G
F
I
G
S
N
I
V
K
A
L
N
D
K
--
G
I
T-----
D
I
L
V
V
D
N
L
K
D
G
T
-------------------
K
F
V
N
L
V
D
L
N
I
A
D
Y
M
D
K
E
D
F
-----
L
I
Q
I
M
A
GEEF
G
-
D
--
V
E
A
I
F
H
E
G
A
C
S
S
T
--
T
E
---
W
D
G
K
Y
M
M
D
N
N
Y
Q
Y
S
K
E
L
L
H
Y
C
L
E
R
E
-
I
-
P
-
F
L
Y
A
S
S
A
A
T
Y
G
G
R
T
S
-----
D
----------------
F
I
E
S
RE--
Y
-------
E
--
K
P
L
N
V
Y
G
Y
S
K
F
L
F
D
E
Y
V
---
R
Q
I
L
P---
E
A
N
S
---
Q
I
-
V
G
F
R
Y
F
N
V
Y
G
P
R
E
G
H
K
------
G
-----
S
M
A
S
V
A
F
H
L
N
T
Q
L
N
---
N
----------------------------
K
-
R
D
F
V
Y
V
G
D
V
A
D
V
N
L
W
F
L
E
N
-----
G
---
V
S
G
---
I
F
N
L
G
T
G
--
R
-
A
E
S
F
Q
A
V
A
D
A
T
------------------------------
Y
Q
----
A
F
T
Q
A
D
L
T
N
L
R
A
-
A
G
Y
D
K
P
F
K
-
T
V
A
E
G
V
T
E
Y
M
A
W
L
N
--------
14
PsiBlast_PDB
52.85
26%
-88
- C1 -
3RUE
2
GNE_PLESH
A:
[26-343]
----------
K
T
W
L
I
T
G
V
A
G
F
I
G
S
N
L
L
E
K
L
L
K
L
--
N
Q
------
V
V
I
G
L
D
N
F
------
S
T
G
H
Q
Y
N
L
D
E
V
K
T
L
-
V
S
T
E
Q
W
S
R
F
C
F
I
E
G
---
D
I
R
D
-----
L
T
T
C
E
Q
----
V
-
M
KG
V
D
H
V
L
H
Q
A
A
L
G
S
V
P
R
S
I
---
V
D
P
I
T
T
N
A
T
N
I
T
G
F
L
N
I
L
H
A
A
K
N
A
Q
-
V
-
Q
S
F
T
Y
A
A
S
S
S
T
Y
G
D
H
P
A
L----
P
----------------
K
V
E
E
----
N
-------
I
-
G
N
P
L
S
P
Y
A
V
T
K
Y
V
N
E
I
Y
A
---
Q
V
Y
A
----
R
--
T
YG
F
K
T
-
I
G
L
R
Y
F
N
V
F
G
R
R
Q
D
P
N
------
G
-----
A
Y
A
A
V
I
P
K
W
T
A
A
M
L
---
K
--
G
--
D
D
V
Y
I
N
------
G
------
D
G
E
T
S
-
R
D
F
C
Y
I
D
N
V
I
Q
M
N
I
L
S
A
L
A
-----
K
DSA
K
D
N
---
I
Y
N
V
A
V
G
--
D
-
R
T
T
L
N
E
L
S
G
Y
I
Y
D
E
L
N
L
I
H
H
I
------
K
Y
-------
R
E
---
F
R
SGDV
R
H
S
Q
A
D
V
T
K
A
I
D
L
L
K
Y
R
-
P
N
I
-
K
I
R
E
G
L
R
L
S
M
P
W
Y
V
R
F
L
K
----
18
PsiBlast_PDB
52.75
26%
-83
- C1 -
3RUC
3
GNE_PLESH
A:
[26-343]
----------
K
T
W
L
I
T
G
V
A
G
F
I
G
S
N
L
L
E
K
L
L
K
L
--
N
Q
------
V
V
I
G
L
D
N
F
------
S
T
G
H
Q
Y
N
L
D
E
V
K
T
L
-
V
S
T
E
Q
W
S
R
F
C
F
I
E
G
---
D
I
R
D
-----
L
T
T
C
E
Q
----
V
-
M
KG
V
D
H
V
L
H
Q
A
A
L
G
S
V
P
R
S
I
---
V
D
P
I
T
T
N
A
T
N
I
T
G
F
L
N
I
L
H
A
A
K
N
A
Q
-
V
-
Q
S
F
T
Y
A
A
S
S
S
T
Y
G
D
H
P
A
L----
P
----------------
K
V
E
E
----
N
-------
I
-
G
N
P
L
S
P
Y
A
V
T
K
Y
V
N
E
I
Y
A
---
Q
V
Y
A
----
R
--
T
YG
F
K
T
-
I
G
L
R
Y
F
N
V
F
G
R
R
Q
D
P
N
------
G
-----
A
Y
A
A
V
I
P
K
W
T
A
A
M
L
---
K
--
G
--
D
D
V
Y
I
N
------
G
------
D
G
E
T
S
-
R
D
F
C
Y
I
D
N
V
I
Q
M
N
I
L
S
A
L
A
-----
K
DSA
K
D
N
---
I
Y
N
V
A
V
G
--
D
-
R
T
T
L
N
E
L
S
G
Y
I
Y
D
E
L
N
L
I
H
H
I
------
K
Y
-------
R
E
---
F
R
SGDV
R
A
S
Q
A
D
V
T
K
A
I
D
L
L
K
Y
R
-
P
N
I
-
K
I
R
E
G
L
R
L
S
M
P
W
Y
V
R
F
L
K
----
29
HHSearch
52.54
21%
-81
- C1 -
2BLL
-
ARNA_ECOLI
A:
[316-655]
----------
M
R
V
L
I
L
G
V
N
G
F
I
G
N
H
L
T
E
R
L
L
R
E
-
D
H
Y
------
E
V
Y
G
L
D
I
G
S
D
A
I
------------
S
R
F
L
-
N
H
P
H
F
H
F
V
E
G
D
I
S
I
---
H
S
-
E
W
----
I
E
Y
H
V
K
------
K
--
C
D
V
V
L
P
L
V
A
I
A
T
P
--
I
E
Y
T
-
R
N
P
L
R
V
F
E
L
D
F
E
E
N
L
R
I
I
R
Y
C
V
K
Y
R
-
K
-
R
-
I
I
F
P
S
T
S
E
V
Y
G
M
C
S
D
-----
K
----------------
Y
F
D
E
D
H
--
S
N
L
I
V
G
P
V
N
--
K
P
R
W
I
Y
S
V
S
K
Q
L
L
D
R
V
I
---
W
A
Y
G
E
---
K
EG
L
---
Q
F
-
T
L
F
R
P
F
N
W
M
G
P
R
L
D
N
L
------
N
AARI-
G
S
S
R
A
I
T
Q
L
I
L
N
L
V
---
E
--
G
--
S
P
I
K
L
I
------
D
------
G
G
K
Q
K
-
R
C
F
T
D
I
R
D
G
I
E
A
L
Y
R
I
I
E
N
AGNR-
C
---
D
G
E
---
I
I
N
I
G
N
P
--
E
N
E
A
S
I
E
E
L
G
E
M
L
L
A
S
F
E
K
H
-
P
L
R
-
H
-
H
F
P
P
FAGFRVV------
V
----
E
H
R
K
P
S
I
R
N
A
H
R
C
L
D
W
E
-
P
K
I
-
D
M
Q
E
T
I
D
E
T
L
D
F
F
L
R
T
V
D
L
T
D
-
44
HHSearch
52.17
22%
-87
- C1 -
3ENK
2
?
A:
[2-337]
------
M
S
T
K
G
T
I
L
V
T
G
G
A
G
Y
I
G
S
H
T
A
V
E
L
L
A
H
--
G
Y
------
D
V
V
I
A
D
N
L
V
N
S
K
R
------
E
A
I
A
R
I
E
K
I
-
T
G
K
T
P
A
F
H
E
T
D
V
S
D
---
E
R
-
A
-----
L
A
R
I
F
D
----
A
H
P
--
I
T
A
A
I
H
F
A
A
L
K
A
V
--
G
E
S
V
-
A
K
P
I
E
Y
Y
R
N
N
L
D
S
L
L
S
L
L
R
V
M
R
E
R
A
-
V
K
R
-
I
V
F
S
S
S
A
T
V
Y
G
V
P
E
R
-----
S
----------------
P
I
D
E
T
F
--
P
-------
L
--
S
A
T
N
P
Y
G
Q
T
K
L
M
A
E
Q
I
L
---
R
D
V
E
A
A
DP
S
--
W
---
R
V
-
A
T
L
R
Y
F
N
P
V
G
A
H
E
S
G
L
I
G
E
D
P
A
G
-----
I
P
N
N
L
M
P
-
Y
V
A
Q
V
A
---
V
--
G
KL
E
K
L
R
V
F
G
SDYPT
P
------
D
G
T
G
V
-
R
D
Y
I
H
V
V
D
L
A
R
G
H
I
A
A
L
D
A
L
E
R
R
-
D
---
A
S
L
---
T
V
N
L
G
T
G
--
R
-
G
Y
S
V
L
E
V
V
R
A
F
E
K
A
S
G
-
R
-
A
V
P
-
Y
E
L
V
A
R
-------
R
P
G--
D
V
----
A
E
C
Y
A
N
P
A
A
A
A
E
T
I
G
W
K
-
A
E
R
-
D
L
E
R
M
C
A
D
H
W
R
W
Q
E
N
N
P
R
G
F
V
-
39
HHSearch
52.05
24%
-82
- C1 -
3KO8
2
?
A:
[1-310]
----------
M
R
I
V
V
T
G
G
A
G
F
I
G
S
H
L
V
D
K
L
V
E
L
--
G
Y
------
E
V
V
V
V
D
N
L
S
S
G
R
-------------
R
E
F
-
V
N
P
S
A
E
L
H
V
R
D
L
K
D
---
Y
S
-
W
-----
G
-
A
G
I
-------
K
--
G
D
V
V
F
H
F
A
A
N
P
E
V
--
R
L
ST-
T
E
P
I
V
H
F
N
E
N
V
V
A
T
F
N
V
L
E
W
A
R
Q
T
G
-
V
R
T
-
V
V
F
A
S
S
S
T
V
Y
G
D
A
D
V
-----
I
----------------
P
T
P
E
EE--
P
-------
Y
--
K
P
I
S
V
Y
G
A
A
K
A
A
G
E
V
M
C
---
A
T
Y
A
R
---
L
FG
V
---
R
C
-
L
A
V
R
Y
A
N
V
V
G
P
R
L
R
H
G
----------------
V
I
Y
D
F
I
M
K
L
R
---
R
--
N
P-
N
V
L
E
V
L
----------------
Q
R
-
K
S
Y
L
Y
V
R
D
A
V
E
A
T
L
A
A
W
K
K
F
E
E
M
D
A
---
P
F
L
---
A
L
N
V
G
N
V
--
D
-
A
V
R
V
L
D
I
A
Q
I
V
A
E
V
L
G
-
L
-
R
P
E
-
I
R
L
V
-----------G--
D
V
----
K
Y
M
T
L
A
V
T
K
L
M
K
L
T
G
W
R
-
P
T
M
-
T
S
A
E
A
V
K
K
T
A
E
D
L
A
K
E
L
W
----
31
HHSearch
51.99
21%
-79
* C1 *
1R6D
2
?
A:
[1-315]
----------
M
R
L
L
V
T
G
G
A
G
F
I
G
S
H
F
V
R
Q
L
L
A
G
--
A
Y
PDVPAD
E
V
I
V
L
D
S
L
T
Y
A
G
N
-----
R
A
---
N
L
A
P
V
D
A
D
P
R
L
R
F
V
H
G
D
I
R
D
---
A
G
-
L
-----
L
A
R
E
L
R
------
G
--
V
D
A
I
V
H
F
A
A
E
S
H
V
--
D
R
S
I
-
A
G
A
S
V
F
T
E
T
N
V
Q
G
T
Q
T
L
L
Q
C
A
V
D
A
G
-
V
G
R
-
V
V
H
V
S
T
N
Q
V
Y
G
S
I
D
S
-----
G
----------------
S
W
T
E
SS--
P
-------
L
--
E
P
N
S
P
Y
A
A
S
K
A
G
S
D
L
V
A
---
R
A
Y
H
R
---
T
YG
L
---
D
V
-
R
I
T
R
C
C
N
N
Y
G
P
Y
Q
H
P
E
---------------
K
L
I
P
L
F
V
T
N
L
L
---
D
--
G
--
G
T
L
P
L
Y
------
G
------
D
G
A
N
V
-
R
E
W
V
H
T
D
D
H
C
R
G
I
A
L
V
L
A
G
G----
R
---
A
G
E
---
I
Y
H
I
G
G
G
--
L
-
E
L
T
N
R
E
L
T
G
I
L
L
D
S
L
G
-
A
-
D
W
S
S
V
R
K
V
A
D
-------
R
K
G--
H
D
----
L
R
Y
S
L
D
G
G
K
I
E
R
E
L
G
Y
R
-
P
Q
V
-
S
F
A
D
G
L
A
R
T
V
R
W
Y
R
E
N
R
G
W
W
E
P
42
HHSearch
51.89
20%
-67
- C1 -
2C5A
13
GME_ARATH
A:
[23-344]
---
Q
Y
W
P
S
E
N
L
K
I
S
I
T
G
A
G
G
F
I
A
S
H
I
A
R
R
L
K
H
E
--
G
H
------
Y
V
I
A
S
D
W
K
K
N
E
H
-------------
M
T
E
-
D
M
F
C
D
E
F
H
L
V
D
L
R
V
---
M
E
-
N
-----
C
L
K
V
T
E
------
G
--
V
D
H
V
F
N
L
A
A
D
M
G
G
--
M
G
FIQ
S
N
H
S
V
I
M
Y
N
N
T
M
I
S
F
N
M
I
E
A
A
R
I
N
G
-
I
K
R
-
F
F
Y
A
S
S
A
C
I
Y
P
E
F
K
Q
LETTN
V
----------------
S
L
K
E
SDAW
P
-------
A
--
E
P
Q
D
A
F
G
L
E
K
L
A
T
E
E
L
C
---
K
H
Y
N
K
---
D
FG
I
---
E
C
-
R
I
G
R
F
H
N
I
Y
G
P
F
G
T
W
K
------
G
-----
G
R
E
K
A
P
A
A
F
C
R
K
A
Q
---
T
--
S
T-
D
R
F
E
M
W
------
G
------
D
G
L
Q
T
-
R
S
F
T
F
I
D
E
C
V
E
G
V
L
R
L
T
K
S
-----
D
---
F
R
E
---
P
V
N
I
G
S
D
--
E
-
M
V
S
M
N
E
M
A
E
M
V
L
S
F
E
E
-
K
-
K
L
P
-
I
H
H
I
P
G
-------
P
E
---
G
V
----
R
G
R
N
S
D
N
N
L
I
K
E
K
L
G
W
A
-
P
N
M
-
R
L
K
E
G
L
R
I
T
Y
F
W
I
K
E
Q
I
E
K
E
K
A
16
PsiBlast_PDB
51.29
26%
-80
- C1 -
3RUH
6
GNE_PLESH
A:
[26-343]
----------
K
T
W
L
I
T
G
V
A
G
F
I
G
S
N
L
L
E
K
L
L
K
L
--
N
Q
------
V
V
I
G
L
D
N
F
------
S
T
G
H
Q
Y
N
L
D
E
V
K
T
L
-
V
S
T
E
Q
W
S
R
F
C
F
I
E
G
---
D
I
R
D
-----
L
T
T
C
E
Q
----
V
-
M
KG
V
D
H
V
L
H
Q
A
A
L
G
S
V
P
R
S
I
---
V
D
P
I
T
T
N
A
T
N
I
T
G
F
L
N
I
L
H
A
A
K
N
A
Q
-
V
-
Q
S
F
T
Y
A
A
S
S
S
T
Y
G
D
H
P
A
L----
P
----------------
K
V
E
E
----
N
-------
I
-
G
N
P
L
S
P
Y
A
V
T
K
Y
V
N
E
I
Y
A
---
Q
V
Y
A
----
R
--
T
YGF
K
T
-
I
G
L
R
Y
F
N
V
F
G
R
R
Q
D
P
N
------
G
-----
A
Y
A
A
V
I
P
K
W
T
A
A
M
L
---
K
--
G
--
D
D
V
Y
I
N
------
G
------
D
G
E
T
S
-
R
D
F
C
Y
I
D
N
V
I
Q
M
N
I
L
S
A
L
A
-----
K
DSA
K
D
N
---
I
Y
N
V
A
V
G
--
D
-
R
T
T
L
N
E
L
S
G
Y
I
Y
D
E
L
N
L
I
H
H
I
------
K
Y
-------
R
E
---
F
R
SGDV
R
H
S
Q
A
D
V
T
K
A
I
D
L
L
K
Y
R
-
P
N
I
-
K
I
R
E
G
L
R
L
S
M
P
W
Y
V
R
F
L
K
----