@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_0810: (2015-12-18 )
MFLRSYPKLRYALCLPLLTETCYSEERTLNKVTTQAKRIFTYNNEFKVTSKELDQRQSNEVKDLFRTNPDVNVGGGSVMGQKIYVRGIEDRLLRVTVDGAAQNGNIYHHQGNTVIDPGMLKSVEVTKGAANASAGPGAIAGVIKMETKGAADFIPRGKNYAASGAVSFYTNFGDRETFRSAYQSAHFDIIAYYTHQNIFYYRSGATVMKNLFKPTQADKEPGTPSEQNNALIKMNGYLSDRDTLTFSWNMTRDNATRLLRSNAIGLAYPCEAPFSPDGAQGCPNVLDSFTRYLYHSINSANNLSLQYKREAGNSFGDPRLDFTLYTSIRNAQFDPLFDPNGVYAKFPTSLASAWERENYPCVEGGYCTPSFSDVDKPSSQPRNLFLNNTGLNLKVAHVIDEATDSLFEYGFNYQNLSVFDARIPKSELYRPNQVYTDDKGQKQIACSLVDNNPNDPTLCQRGKANGNIYGGYVQANYSPHKIITFGAGVRWDAYTLYDKDWNHRYTQGFSPSAALVISPIEPLSLKITYSQVTRGVMPGDGVYMRQNDLRYAKNIKPEVGSNAEFNIDYSSQYFSGRAAAFYQALDNFISQYAQRLIVTNLSQAIRIYGYEVGGTFRYKGVSLNVGISRTWPTTRGYLMADSYELAASTGNVFIIKLDYTIPKTGINLAWLSRFVTGLDYCGFDIYLPDYGTAEKPKTPTDLAKCGSQLGLVHMHKPGYGVSNFYINWSPKTKSHWKGLLLSAVFNNVFNKFYVDQTSPYVMSPDMPGTDAIKRAIAEPGFNARFEVAYKW
Atome Classification :
(20 SA)
---------------------------------------.........10.---------------.......20........30........---------40......-----------------------..50......-..60......------------------------..70..-...-.-----.-.----80----..---...---....---90--.------.--------------.......100.--------...-..------.------------.---110-...----.--.....120.......130.......140.......150...-..-..160......-.------170----.------.-.-...--------.-..180-..---.....190.....--..--200.....--..-210------------------------------------.-------------...-....-.220........230......--.240........250----------------.....---------------.-----------------.--260.-......-------------.270..-----...--..280.---.------.---...------.290........300.......310....-.--.------------------------------.320.........330......---.340.......350.......360--......-..---------------------370.......380.......390-.-.......400.------........--410......--------------.420--...---.-..-.430--.....--------..--440-----..----.----------....-..450------------------...------......460----------.......470.......480.--.......----490.......500---.------------------------------------....--------....510.......520........530-........540--....-------.---------..550-.....--..560.-..-....570.-------.-------.......580.......590.--------------.-------------------------.....600..-----.....610---......----.----..-------620...--....630--------.....--.----.------640-----------------------------..-.---....-..650.......660.----.....------.670......--.680-----....----------....690.......700.--......710.....----...-720.......730.---...-...740.......750.......760-------..---.-.---.---.--..770.......780.....-------------------------------..790---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
---------------------------------------MFLRSYP
K
L
R
Y
A
---------------
L
C
L
P
L
L
T
E
T
CYSEE
R
T
L
N
K
V
T
TQ
A
K
R
I
---------
F
T
YNN
E
F
K
-----------------------V
T
S
K
E
L
D
Q
R
Q
-
S
N
E
V
K
D
L
F
RT------------------------NPDVNV-GGG-S-----V-M----G-----
Q
K
---
I
Y
V
---RGIE---D---
R
------
L
--------------
L
R
V
T
VDGA-AQ--------NG
N
-
I
Y
------H------------H---Q---G
N
T
----V--IDPGM
L
K
S
V
E
VTKGAANASAGPG
A
I
A
G
V
I
K
M
ETKGAADFIP-RG-KNYAASG
A
V
S
F
-
Y
------T------N------F-G-
D
R
E
--------
T
-
F
R
S
A
Y
-
Q
S---A
H
F
D
I
I
A
Y
Y
T
H
Q
N
--
I
F
--
Y
YRS
G
A
T
V
--
M
K
-
N
--------------------------------------L-------------FKP-TQAD-KE-PGTPSEQN
N
A
L
I
K
MNGYL--SD-R
D
T
L
T
F
S
W
NMTR----------------
D
N
A
T
R
---------------
L
-----------------
L
--R-SN-AIGLAY-------------PCEAPF-----SPD--GAQG
C
P
---
N
------
V
---
L
D
S
------
F
T
-
R
Y
L
Y
H
SINSANN
L
S
L
Q
Y
K
REAGNSFG-D--P------------------------------
R
L
--
D
F
T
L
Y
T
SIRNAQFDPLFD---PNG
V
Y
AKF
P
T
S
L
A
S
A
W
ERENYPC---VEGGYC-TP---------------------SFSDVDKPSSQP
R
N
L
F
L
NNTGL--
N
-
L
K
V
A
H
V
I
D
--
E
------
A
T
D
S
L
F
E
Y--GFNYQ
N
L
S
V
--------------
F
DAR--I
P
K
---
S
-EL-YRPN--QVYTD--------DK--G-------Q
K
----
Q
----------
I
A
C
S
-LVD--------------------NNP------N
D
P
T
L
C
QRG----------KANG
N
I
Y
G
G
Y
V
Q
ANYSP
H
K
-
I
--
I
T
FGAG
V
----
R
W
D
A
Y
T
L
YDKD-----W------------------------------------NHRY--------TQGFSPS
A
A
L
V
I
SPI-E
P
L
S
L
K
I
T
Y
S
Q
--VTRGVMPGD
G
V
--
Y
M
RQ-------N---------D
L
R
Y
A
-KNIKP--EVGSN
A
-
E
F
-
N
I
D
YS--S-------Q-------YFS
G
R
A
A
A
F
Y
Q
A
L
D
N
F
I
S
Q
Y
A
--------------
Q
-------------------------
R
L
I
V
T
N
L
S
Q
A
-----
I
R
I
Y
G
Y
-----EVG
G
T
F
----
R
----
Y
K
-------
G
V
S
L
N
V--GISRTWP--------TTR
G
Y
--
L
----
M
------A-------------------------------D
S
-
Y
---
E
L
AA-STG
N
V
F
I
I
K
L
D
Y
TIPK----TGI
N
L
------
A
W
L
S
R
F
V
T
G
L
--DYC------
G
F
D
I
----------YLPDYGTAEKPK
T
P
T
D
L
A
--
K
C
G
S
QL
G
-
L
V
H
MHK----PGY-GV
S
N
F
Y
I
N
WSPKT
K
---
S
H
W
-
K
G
L
L
L
S
A
V
F
N
N
V
F
N
K
FYVDQTS
P
Y
V
--------MS---P-D---M---P--
G
T
D
A
I
K
R
A
I
AEPGFN
A
R
F
E
V
-------------------------------
A
YKW----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
89.45
22%
-6
- C3 -
4AIP
3
?
A:
[61-742]
------------------------------------------------------------------------------------------
D
R
Q
---------
G
S
K
I
R
T
N
I
-----------------------
V
T
L
Q
Q
K
D
E
S
T
-
A
T
D
M
R
E
L
L
K
E
------------------------
E
P
S
I
D
F
-
G
G
G
-
N
-----
G
-
T
----
S
-----
Q
F
---
L
T
L
---
R
G
M
G
---
Q
---
N
------
S
--------------
V
D
I
K
V
D
N
A
-
Y
S
--------
D
S
Q
-
I
L
------
Y
------------
H
---
Q
---
G
R
F
----
I
--
V
D
P
A
L
V
K
V
V
S
V
Q
K
G
A
G
S
A
S
A
G
I
G
A
T
N
G
A
I
I
A
K
T
V
D
A
Q
D
L
L
K
G
L
D
-
K
N
W
G
V
R
L
N
S
G
F
-
A
------
S
------
N
------
N
-
G
-
V
S
Y
--------
G
-
A
S
V
F
G
-
K
E
---
G
N
F
D
G
L
F
S
Y
N
R
N
D
--
E
K
--
D
Y
E
A
G
K
G
-----------------------------------------------------------
F
R
N
-
V
N
G
G
-
K
T
V
P
Y
S
A
L
D
K
R
S
Y
L
A
K
I
G
T
T
F
--
G
D
-
D
D
-----------------------------
H
R
---------------
I
-----------------
V
--
L
-
S
H
-
M
------------------------------
K
D
--
Q
H
R
G
I
R
---
T
------
V
---
R
E
E
------
F
T
-
V
G
D
K
S
S
R
I
N
I
D
R
Q
A
P
A
Y
-
R
E
T
T
Q
S
-----------------------------------------
N
T
N
L
A
Y
T
G
K
N
L
G
F
V
E
K
L
D
---
A
N
----------
A
Y
V
L
E
K
E
R
Y
S
A
---
D
D
S
G
---
T
G
---------------------
Y
A
G
N
V
K
G
P
N
----
H
T
R
I
T
T
R
G
A
--
N
-
F
N
F
D
S
R
L
A
--
E
------
Q
T
--
L
L
K
Y
--
G
I
N
Y
R
H
Q
E
I
K
P
QAF---------
L
N
S
K
FS
I
P
T
-------------------------------
P
-------
M
E
----
Q
----------
Q
M
K
D
-
R
A
D
--------------------
E
D
T
V
H
A
Y
K
L
S
N
P
T
K
T
D
T
G
----------
V
--------
Y
I
E
A
---
I
H
D
-
I
GD
F
T
L
T
G
G
L
----
R
Y
D
R
F
K
V
K
T
H
D
-----
G
------------------------------------
K
T
V
S
--------
S
S
N
L
N
P
S
F
G
V
I
W
Q
P
H
-
E
H
W
S
F
S
A
S
H
N
Y
--
A
S
R
S
P
R
L
Y
D
A
L
QT
H
G
K
R
-------
G
---------
I
I
S
I
A
-
D
G
T
K
A
--
E
R
A
R
N
T
-
E
I
-
G
F
N
Y
N
--
D
-------
G
-------
T
F
A
A
N
G
S
Y
F
W
Q
T
I
K
D
A
L
A
N
P
Q
---------------------------------------------
A
V
R
E
A
V
NA
G
Y
I
K
N
H
G
Y
-----
E
L
G
A
S
Y
----
R
----
T
G
-------
G
L
T
A
K
V
--
G
V
S
H
S
K
P
R
F
Y
D
----
T
H
K
D
K
--
L
----
L
------
S
-------------------------------
A
N
-
P
---
E
F
G
A
-
Q
V
G
R
T
W
T
A
S
L
A
Y
R
F
Q
N
----
P
N
L
E
I
------
G
W
R
G
R
Y
V
-------------------------------------
Q
K
A
T
G
S
I
L
A
AG
Q
K
----
N
-
L
E
N
V
V
R
----
K
G
F
-
G
V
N
D
V
F
A
N
W
K
P
L
G
K
---
D
T
----
L
N
V
N
L
S
V
N
N
V
F
N
K
F
Y
Y
P
H
S
Q
R
W
T
--------
N
T
---------
L
---
P
--
G
V
----------
G
R
D
V
R
L
G
V
-------------------------------
N
Y
K
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
HHSearch
80.48
20%
-16
- C3 -
3FHH
5
?
A:
[2-640]
-----------------------------------------------------------------------------------
E
T
M
T
V
T
A
T
G
N
ARSSF----
E
A
P
M
M
V
S
V
-----------------------
I
D
T
S
A
P
E
N
Q
T
-
A
T
S
A
T
D
L
L
R
H
------------------------
V
P
G
I
T
L
-
D
G
T
-
G
R----
T
-
N
----
G
-----
Q
D
---
I
N
M
---
R
G
Y
D
---
H
---
R
------
G
--------------
V
L
V
L
V
D
G
I
-
R
Q
--------
G
T
D
-
T
-------
G
------------
H
---
L
---
N
G
T
----
F
--
L
D
P
A
L
I
K
R
V
E
I
V
R
G
P
S
A
L
L
Y
G
S
G
A
L
G
G
V
I
S
Y
D
T
V
D
A
K
D
L
L
Q
-
E
G
-
Q
S
S
G
F
R
V
F
G
T
G
-
G
------
T
------
G
------
D
-
H
S
L
G
L
--------
G
-
A
S
A
F
G
-
R
T
---
E
N
L
D
G
I
V
A
W
S
S
R
D
--
R
G
--
D
L
R
Q
S
N
G
E
--
T
-------------------------------------------------------------------
A
P
N
D
E
S
I
N
N
M
L
A
K
G
T
W
Q
I
--
D
S
-
A
Q
S
L
S
G
L
V
R
Y
Y
N
----------------
N
D
A
R
E
---------------
P
-----------------
K
--
N
-
P
Q
-
T
V
E
--
A
-------------
S
-----------
E
-----
S
S
N
P
----------
M
----
V
D
------
R
S
--------
T
I
Q
R
D
A
Q
L
S
Y
K
L
A
P
Q
---
G
-
N
--
D
WL----------------------------
N
A
--
D
A
K
I
Y
W
S
E
V
R
--
I
N
-------
A
Q
------------------------------------------------------------------
E
Y
R
E
Q
I
T
K
G
A
--
R
-
L
E
N
R
S
T
L
F
AD
S
------
F
A
S
H
L
L
T
Y
--
G
G
E
Y
Y
R
Q
E
Q
--------------
G
S
H
-------------------------------------------------------------------------------------------------------
T
T
G
F
P
----------
Q
A
K
I
D
F
S
S
G
W
L
Q
D
E
I
T
L
R
D
L
P
--
I
T
L
L
G
G
T
----
R
Y
D
S
Y
R
G
S
S
D
G
-----
Y
------------------------------------
K
D
V
D
--------
A
D
K
W
S
S
R
A
G
M
T
I
N
P
T
-
N
W
L
M
L
F
G
S
Y
A
Q
--
A
F
R
A
P
T
M
G
E
M
Y
--
N
D
S
K
-------
H
FSIGRF
Y
T
N
Y
W
V
P
N
-
P
N
L
R
P
--
E
T
N
E
T
Q
-
E
Y
-
G
F
G
L
R
--
F
-------
D
DLMLSN
D
A
L
E
F
K
A
S
Y
F
D
T
K
A
K
D
Y
I
S
T
T
V
--------------
D
FAAA---------------------
T
T
M
S
Y
N
-
V
P
N
-----
A
K
I
W
G
W
-----
D
V
M
T
K
Y
----
T
----
T
D
-------
L
F
S
L
D
V
--
A
Y
N
R
T
R
G
--------
K
D
T
D
-----------------------------------------------
T
G
-
E
---
Y
I
S
S
-
I
N
P
D
T
V
T
S
T
L
N
I
P
I
A
H
----
S
G
F
S
V
------
G
W
V
G
T
F
A
D
R
S
--
T
H
I
------
S
-----------------------------------------
S
---
K
Q
----
P
G
Y
-
G
V
N
D
F
Y
V
S
Y
Q
G
Q
Q
A
---
L
K
G
-
M
T
T
T
L
V
--
L
G
N
A
F
D
K
E
Y
W
S
P
Q
-------------------------------------
G
I
P
Q
D
G
R
N
G
K
I
F
V
-------------------------------
S
Y
Q
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
HHSearch
80.38
16%
-9
- C3 -
3V8X
4
TBP1_NEIMB
A:
[43-904]
---------------------------------------------------------------------------------------------E--------
V
T
G
L
G
K
L
V
-----------------------
K
S
S
D
T
L
S
K
E
Q
-
V
L
N
I
R
D
L
T
R
Y
------------------------
D
P
G
I
A
V
-
V
E
Q
G
R
-----
G
-
A
----
S
-----
S
G
---
Y
S
I
---
R
G
M
D
---
K
---
N
------
R
--------------
V
S
L
T
V
D
G
V
-
S
Q
--------
I
Q
S
-
Y
T
------
A
QAALGG
T
R
T
A
G
S
S
---
G
---
A
I
N
----
E
--
I
E
Y
E
N
V
K
A
V
E
I
S
K
G
S
N
S
V
E
Q
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--------
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---
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----------------
Q
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---------------
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-----------------
D
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L
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-------------
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------
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------------------------------
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-------
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------
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---
R
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A
D
K
-
P
F
---------------------
S
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--
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V
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L
L
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--
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-
F
K
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D
-----------
K
I
R
H
N
L
S
V
N
L
G
F
D
R
F
G
S
N
L
--------------
R
H
Q
D
--
Y
Y
Y
---
Q
--
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-
A
N
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A
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QNNG
K
K
I
S
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GS
E
-------
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----
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W
V
T
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G
R
G
N
V
V
T
G
Q
-
I
C
R
--------------------
L
G
N
------
N
T
Y
T
D
C
T
P
R
----------
S
I
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G
K
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Y
Y
A
A
V
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D
N
V
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L
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R
-
W
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----
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-----
G
SV----------------------------------
S
T
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T
--------
H
R
T
L
S
W
N
A
G
I
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-
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R
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--
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--
G
W
R
A
-------
G
---------
V
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G
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L
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R
D
L
I
V
R
G
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--------------
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A
Q
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DG
K
E
E
A
K
G
-------------
D
P
A
Y
L
N
-
A
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-----
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-----
N
I
L
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----
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--
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V
--------
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I
K
K
--
R
ADRT
D
------
I
-------------------------------
Q
S
-
H
---
L
F
D
A
-
I
Q
P
S
R
Y
V
V
G
L
G
Y
D
Q
P
E
----
G
K
W
G
V
------
N
G
M
L
T
Y
S
K
A
K
--
E
I
T
------
E
L
L
G
----------
S
R
A
----------
L
L
N
----
G
N
S
R
N
T
K
-
A
T
A
R
R
T
----
R
P
W
-
Y
I
V
D
V
S
G
Y
Y
T
V
K
------
K
H
-
F
T
L
R
A
G
--
V
Y
N
L
L
N
Y
R
Y
V
T
W
E
N
V
R
Q
--------
T
A
---
G
-
G
---
A
VNQ
H
--
K
N
V
G
V
Y
N
R
Y
A
A
P
G
R
N
Y
T
F
S
L
-------------------------------
E
Y
K
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
Fugue
77.78
16%
-8
- C3 -
3V89
-
TBP1_NEIMB
A:
[51-915]
-----------------------------------------------------------------------------------------
R
D
N
E
---------
V
T
G
L
G
K
L
V
-----------------------
K
S
S
D
T
L
S
K
E
Q
-
V
L
N
I
R
D
L
T
R
Y
------------------------
D
P
G
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A
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V
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Q
G
-
R
-----
G
-
A
----
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-----
S
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---
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S
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---
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G
M
D
---
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---
N
------
R
--------------
V
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-
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Q
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Q
A
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------
R
------------
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---
A
---
G
S
S
GA
I
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--
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-
S
------
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K-----
N
------
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-
G
-
L
T
Q
--------
S
-
I
A
L
A
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-
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I
---
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G
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L
L
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T
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R
R
--
A
G
--
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D
A
--
G
R
-
G
--------------------------------------
V
-------------
Q
S
F
-
N
R
L
V
-
P
V
-
E
D
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S
N
Y
A
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C
K
N
G
--
S
Y
-
E
T
C
K
A
N
P
K
K
D
V
V
----------------
G
K
D
E
R
---------------
Q
T
V
STRDYTGPNRFLA
D
P
L
--
S
-
Y
E
-
S
R
S
W
L
F
-------------
R
P
G
F
R
F
-----
E
N
K
--
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H
Y
I
G
G
---
I
------
L
---
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------
Q
Q
-
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M
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A
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L
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K
A
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F
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A
N
K
K
Q
A
G
-
S
--
L
PGNGKYAGNHKYGG
L
F
T
N
G
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A
L
V
G
AE
Y
G
T
G
--
V
F
Y
D
E
T
H
T
K
S
R
Y
G
L
E
Y
V
Y
---
T
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A
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K
D
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N
H
F
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C
-
S
A
DGSDKY
C
R
P
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ADKPF
S
Y
Y
K
S
D
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I
Y
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H
R
L
L
Q
A
A
F
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K
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F
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--
N
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L
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N
L
G
F
D
--
R
------
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G
S
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L
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--
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Y
Y
Y
Q
H
A
N
R
--------------
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Y
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S
--
N
T
P
---
P
-
Q
--
N
N
G
K
--
K
I
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N
--------
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--
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-------
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S
----
P
----------
Y
W
V
T
-
I
G
R
--------------------
G
N
V
------
V
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G
Q
I
C
R
L
G
NNTYTDCTPR
S
I
N
G
K
S
Y
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A
A
V
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D
N
V
R
L
G
R
-
W
--
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A
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L
----
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Y
D
Y
R
S
T
H
S
D
D
GS---
V
------------------------------------
S
T
G
T
--------
H
R
T
L
S
W
N
A
G
I
V
L
K
P
T
-
D
W
L
D
L
T
Y
R
T
S
T
--
G
F
R
L
P
S
F
A
E
M
Y
--
G
W
R
A
-------
G
---------
V
Q
S
K
A
-
V
K
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P
--
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K
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N
K
-
E
A
-
G
I
V
F
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--
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-------
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-------
F
G
N
L
E
A
S
W
F
N
N
A
Y
R
D
L
I
V
R
G
Y
--------------
E
-------------------------
A
Q
I
K
D
G
K
E
E
A
-----
K
G
D
P
A
Y
-----
L
N
A
Q
S
A
----
R
----
I
T
-------
G
I
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I
L
G
--
K
I
D
W
N
G
W
--------
Y
S
T
F
A
--
Y
----
N
------
R
-------------------------------
V
R
-
V
---
R
D
I
K
-
K
R
A
D
R
T
D
I
Q
------
S
----
H
L
F
D
A
------
I
Q
P
S
R
Y
V
V
G
L
--
G
Y
D
Q
PEGK
W
G
V
N
G
----------
M
L
T
Y
S
K
A
K
E
I
T
E
L
L
G
S
R
A
--
L
L
N
G
N
S
R
-
N
T
K
A
T
A
----
R
R
T
-
R
--
P
W
Y
I
V
D
V
S
G
Y
Y
---
T
V
K
-
K
H
F
T
L
R
A
G
V
Y
N
L
L
N
Y
R
Y
V
T
W
E
N
V
R
Q
--------
T
A
GGA
V
-
N
---
Q
---
H
--
K
N
V
G
V
Y
N
R
Y
A
A
P
G
R
N
Y
T
F
S
L
-------------------------------
E
M
K
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
HHSearch
77.25
17%
-1
* C3 *
3CSL
6
?
A:
[113-865]
---------------------------------------------------------------------------------------------NDWVY----
D
E
P
R
S
V
S
V
-----------------------
I
S
R
E
Q
M
D
N
R
P
-
A
R
H
A
A
D
I
L
E
Q
------------------------
T
T
G
A
Y
S
-
S
V
S
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Q
-----
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-
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----
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-----
L
S
---
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N
I
---
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G
I
Q
---
D
Y--
G
------
R
--------------
V
N
M
N
I
D
G
M
-
R
Q
--------
N
F
Q
-
K
S
------
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------------
H
---
G
QRN
G
T
M
----
Y
--
I
D
S
E
L
L
S
G
V
T
I
D
K
G
T
T
G
G
M
G
S
A
G
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G
G
I
A
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F
N
T
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S
A
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D
F
L
A
-
P
G
-
K
E
L
G
G
K
L
H
A
S
T
-
G
------
D
------
N
------
G
-
T
-
H
F
I
--------
G
S
G
I
L
A
L
-
G
N
---
E
T
G
D
I
L
L
A
A
S
E
R
H
--
L
G
--
D
Y
W
P
G
N
K
G
--
D
I
G
N
IRINNDTGN
Y
D
---------------------------
R
-------------
Y
A
E
S
I
K
N
N
-
K
I
-
P
D
T
H
Y
R
M
H
S
R
L
A
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V
G
W
N
L
--
P
A
-
N
Q
R
L
Q
L
S
Y
L
Q
T
Q
----------------
T
A
S
P
I
---------------
A
-----------------
G
-----
T
-
L
T
N
L
-
G
-------------
T
--
R
P
P
-----
Y
E
L
----
G
-
W
----------------
K
R
------
T
G
-----
Y
T
D
V
M
A
R
N
A
A
F
D
Y
S
L
A
P
E
D
-
V
D
-
W
--
L
------------------------------
D
F
--
Q
A
K
L
Y
Y
V
D
T
Q
D
D
S
D
-------
T
Y
S
------------------
T
S
---
S
L
-----
L
D
-------------------------
N
G
----
Y
A
T
R
T
R
L
R
T
Y
G
A
--
Q
-
A
Q
N
T
S
R
F
S
LA
P
------
G
H
D
F
R
A
N
Y
--
G
L
E
F
Y
Y
D
K
A
--------------
T
S
D
S
--
S
R
Q
---
G
----
M
E
----------------------------------------------------------------------------------------
G
V
T
P
----------
A
G
N
R
S
V
A
S
L
F
A
N
L
T
Y
D
Y
D
G
-
W
--
L
T
L
E
G
G
L
----
R
Y
D
R
Y
R
L
R
G
Q
T
-----
G
L
S
Y
PDLAKDGQRYTIDNPCKALRLTGC
S
T
T
T
R
E
D
W
D
V
D
R
D
--------
Q
G
K
L
S
P
T
L
A
V
A
V
R
P
G
V
E
W
L
E
L
Y
T
T
Y
G
K
--
S
W
R
P
P
A
I
T
E
T
L
--
T
N
G
S
AHSS---
S
---------
T
Q
Y
P
N
-
P
F
L
Q
P
--
E
R
S
R
A
W
-
E
V
-
G
F
N
V
Q
--
Q
P
DLWFEG
D
-------
R
L
V
A
K
V
A
Y
F
D
T
K
V
D
N
Y
I
N
L
A
I
--------------
D
RNKPG
L
V
Q
P
S
IGN------------
A
A
Y
V
N
N
-
L
S
K
-----
T
R
F
R
G
L
-----
E
Y
Q
L
N
Y
----
D
----
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-------
V
F
Y
A
D
L
--
T
Y
T
H
M
I
G
--------
K
N
E
F
C
S
N
K
----
A
------
W
LGG
R
L
R
Y
G
DGSRRGNFYVEPD
A
A
S
N
D
F
V
T
C
D
G
G
-
T
QFG
S
A
A
Y
-
L
P
G
D
R
G
S
V
T
L
G
G
R
A
F
D
----
R
K
L
D
A
------
G
V
T
V
R
F
A
P
G
Y
--
Q
D
S
------
S
V
P
-----------------------------------
S
N
Y
-
P
Y
L
A
D
W
----
P
K
Y
-
T
L
F
D
L
Y
A
S
Y
K
L
T
------
D
S
-
L
T
L
R
G
S
--
V
E
N
L
T
N
R
A
Y
V
V
S
Y
G
E
T
--------------------------------
L
A
N
T
L
G
R
G
R
T
V
Q
G
G
V
-------------------------------
E
Y
R
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
Fugue
77.22
16%
-1
- C3 -
2IAH
3
FPVA_PSEAE
A:
[1-772]
Q
E
V
E
F
D
I
P
P
QA
L
G
S
A
L
Q
E
F
G
R
Q
A
D
I
Q
V
L
Y
R
PEEVRN
K
R
S
S
A
I
K
G
K
L
E
P
N
Q
A
---------------
I
-
T
E
L
L
R
G
T
G
A
S
V
D
F
Q
G
N
A
I
T
I
S
V
A
T
I
---------
T
E
D
S
G
S
Y
T
PGTIATATRLVLTPRETP
Q
S
I
T
V
V
T
R
Q
N
M
D
D
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-
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M
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------------------------
T
P
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-
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Y
-
D
-----
T
-
D
----
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-----
N
N
---
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Y
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---
R
G
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--------------
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--------------
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D
G
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--------
A
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-
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------
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------------
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---
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---
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----
L
--
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L
L
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A
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-
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------
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------
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--------
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---
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------
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--
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-
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--------------------------------------
V
-------------
Y
Y
G
-
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----------------
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---------------
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A
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W
--------------------------------------
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------
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---
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-
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F
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L
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-
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--
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------------------------------
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------
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---
D
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---
L
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-
F
L
---------------------
G
------------
R
E
H
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L
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--
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-
A
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S
H
W
E
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--
K
------
S
Y
W
N
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R
N
Y
--
D
N
T
T
D
D
F
I
N
--------------
W
D
G
D
--
I
G
K
--------------------------------------------------------------------------------------
P
------
D
W
G
T
P
S
Q
Y
I
----------
D
D
K
T
R
Q
L
G
S
Y
M
T
A
R
F
N
V
T
D
-
D
--
L
N
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G
----
R
V
V
D
Y
R
V
T
G
L
N
-----
P
------------------------------------
T
I
R
E
--------
S
G
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I
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Y
V
G
A
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-
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---------
N
-----
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L
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-
G
I
K
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-------
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A
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--------------
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-------------------------
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T
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--------
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-----
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----
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----
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K
-------
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--------
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Q
A
G
Y
--
T
----
H
------
K
-------------------------------
I
I
-
R
---
D
D
S
G
-
K
K
V
S
T
W
E
P
Q
D
Q
L
S
L
Y
T
----
S
Y
K
F
K
------
G
A
L
D
K
L
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G
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--
G
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R
------
W
Q
G
-------------
K
S
W
Q
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Y
N
N
P
R
S
------------
R
-
W
E
K
F
S
Q
----
E
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Y
-
W
L
V
D
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M
A
R
Y
Q
I
T
---------
D
K
L
S
A
S
V
N
V
N
N
V
F
D
K
T
Y
Y
T
N
I
G
F
Y
--------------------------------
T
S
A
S
Y
G
D
P
R
N
L
M
F
S
T
-------------------------------
R
W
D
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
Fugue
70.40
17%
-20
* C4 *
4M5D
14
UTP22_YEAST
A:
[81-1237]
-------------------------------T
A
T
E
S
Y
D
I
H
I
A
R
E
T
A
E
L
F
K
S
---------------
N
I
F
K
L
Q
I
D
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L
L
E
Q
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K
L
K
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K
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V
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---------
L
H
K
L
Y
D
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L
-----------------------
Q
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S
-
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-----
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---
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---
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L
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KELFEKKDFLN
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L
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--------
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------
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------------
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---
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---
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G
F
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------
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-
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--------------------------------------
S
-------------
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L
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-
F
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GGGINSNKILLHG
F
S
S
Y
Q
---------------
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-----------------
F
--
K
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G
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--
G
F
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T
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---
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L
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-
K
M
T
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S
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L
N
N
V
V
Q
-
D
QF
S
------------------------------
N
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--
F
L
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N
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S
R
F
D
N
L
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D
L
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Y
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N
L
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T
S
L
A
A
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------------------------------------------------
G
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R
V
K
F
I
T
---
L
--
E
-
N
F
L
A
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K
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--
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------
V
A
R
Y
A
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--
R
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--------------
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-----
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N
--------
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--
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-------
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FNFD
F
----------
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R
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-
L
I
V
--------------------
N
P
S
------
E
C
D
K
L
V
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----------
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A
H
S
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S
-------
T
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A
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----
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R
R
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-----
I
------------------------------------
T
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--------
V
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S
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-------
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---------
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K
F
-
H
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F
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L
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K
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--------------
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-------------------------
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-----
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Y
----
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F
Q
-------
D
V
I
L
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--
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P
K
W
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I
T
S
L
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K
A
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A
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--
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----
L
------
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-------------------------------
I
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---
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L
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--
D
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L
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----------
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A
N
A
R
N
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L
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P
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A
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L
--
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L
-
A
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----
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P
F
--------
V
D
---
P
-
A
PYF
I
---
P
--
G
S
-------
L
E
N
G
F
L
K
V
L
K
F
-------------------------------
I
S
Q
W
NWKD
D
P
L
I
L
DLVKPEERLT
L
A
Q
Y
K
G
I
Q
M
N
F
T
N
L
R
N
SDPNGTHLQFFVASKNDPSGILYSSGIP
L
P
I
A
T
R
L
T
A
L
A
K
V
A
V
N
L
L
Q
T
HGLN
Q
Q
T
I
N
L
L
F
TPGLKDYD
F
V
V
D
L
R
T
PIGLKSSCGILSAPSNFPENLNDLSEKMD
P
T
Y
Q
L
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Y
L
N
L
K
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KN
S
L
I
L
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R
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G
A
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FRVNLDCNVKPVDDENVILN
K
E
A
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H
E
I
A
A
F
G
NDMVI
N
F
E
T
D
26
HHSearch
70.01
14%
-13
- C3 -
2HDI
2
CIRA_ECOLI
A:
[7-639]
-----------------------------------------------------------------------------------
E
T
M
V
V
T
A
S
S
V
E
Q
N
LK----
D
A
P
A
S
I
S
V
-----------------------
I
T
Q
E
D
L
Q
R
K
P
-
V
Q
N
L
K
D
V
L
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E
------------------------
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V
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L
-
T
N
E
-
G
-----
D
-
N
----
R
-----
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G
---
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S
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---
R
G
L
D
---
S
---
S
------
Y
--------------
T
L
I
L
V
D
G
K
-
R
V
--------
N
S
R
-
N
A
------
V
FRHN--------
D
---
F
---
D
L
N
----
W
--
I
P
V
D
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K
K
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--------
K
W
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T
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-
T
------
I
------
Q
EHRD
R
G
D
-
T
-
Y
N
G
--------
Q
-
F
F
T
S
G
-
P
L
ID-
G
V
L
G
M
K
A
Y
G
S
L
A
K
--
R
E
K
D
D
-------------------------------------------------------------------------------
E
G
F
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A
W
T
P
--
N
Q
-
N
H
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A
G
Y
G
F
D
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----------------
Q
D
R
D
S
-------------------------------------------------------------------------------------------------
N
R
------
L
E
----------
R
Q
N
Y
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V
S
H
N
G
R
----
W
D
-
Y
--
G
------------------------------
T
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--
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L
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Y
Y
G
E
K
----
V
E
---
N
---
K
N
P
-----------------------
G
---
N
S
-
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-----------------------------------
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S
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T
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--
D
-
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---------
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I
N
Q
F
L
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V
--
G
G
E
M
R
H
D
K
M
--------------
S
D
A
V
--
N
L
T
----------
G
---------------------------------------------------------------------------------------
G
T
S
S
----------
K
T
S
A
S
Q
Y
A
L
F
V
E
D
E
W
R
I
F
E
-
P
--
L
A
L
T
T
G
V
----
R
M
D
D
H
E
T
Y
---------------------------------------------------------
G
E
H
W
S
P
R
A
Y
L
V
Y
N
A
T
-
D
T
V
T
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G
G
W
A
T
--
A
F
K
A
P
S
L
L
Q
L
S
--
P
D
W
T
S
N
S
CRGA
C
---------
K
I
V
G
S
-
P
D
L
K
P
--
E
T
S
E
S
W
-
E
L
-
G
L
Y
Y
M
--
G
-------
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G
V
E
S
S
V
T
V
F
R
N
D
V
K
D
R
I
S
I
S
R
--------------
T
SDVNAAPGYQNFV
G
F
E
T
G
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R
R
I
P
V
F
S
Y
Y
N
-
V
N
K
-----
A
R
I
Q
G
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-----
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T
E
L
K
I
----
P
----
F
N
D------
E
W
K
L
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--
N
Y
T
Y
N
D
G
--------
R
D
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S
N
--
G
-------------------------------------------
E
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---
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L
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F
H
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A
N
G
T
L
D
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K
P
L
A
L---
E
D
W
S
M
------
Y
M
S
G
H
Y
T
G
Q
K
---------------------------------------------------------------
G
G
Y
-
T
I
W
N
T
G
A
A
W
Q
V
T
------
K
D
-
V
K
L
R
A
G
--
V
L
N
L
G
D
K
D
L
S
R
-----------------------------------------
N
E
D
G
R
R
Y
F
M
A
V
-------------------------------
D
Y
R
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
HHSearch
68.71
13%
-0
- C3 -
2W16
8
FPVA_PSEAE
A:
[108-772]
-------------------------------------------------------------------------------------
T
I
A
T
A
T
R
L
VLTPR----
E
T
P
Q
S
I
T
V
-----------------------
V
T
R
Q
N
M
D
D
F
G
-
L
N
N
I
D
D
V
M
R
H
------------------------
T
P
G
I
T
V
-
S
A
Y
-
D
-----
T
-
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----
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-----
N
N
---
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---
R
G
F
S
---
I
---
N
------
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----------------
F
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Y
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P
S
--------
T
A
R
-
N
V
------
G
------------
Y
---
S
A--
G
N
T
----
L
--
S
D
M
A
I
Y
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R
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G
L
L
T
G
A
G
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G
A
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--------
E
F
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V
E
L
G
A
-
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------
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------
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------
D
-
N
-
Y
R
S
--------
E
-
L
D
V
S
G
-
P
L
TES
G
N
V
R
G
R
A
V
A
A
Y
Q
D
--
K
H
--
S
F
M
D
H
Y
---------------------------------------------------------------------------
E
R
K
T
S
V
Y
Y
G
I
L
E
F
D
L
--
N
P
-
D
T
M
L
T
V
G
A
D
Y
Q
D
----------------
N
D
P
K
G
---------------
S
-----------------
G
--
W
S
G
S
-
F
P
L
F
-
D
-------------
S
Q
G
N
R
N
-----
D
V
-----
S
R
S
F
---
N
------
N
---
G
A
K
------
W
S
-----
S
W
E
Q
Y
T
R
T
V
F
A
N
L
E
H
N
----
F
--
A
--
N
------------------------------
G
W
--
V
G
K
V
Q
L
D
H
K
I
N
G
Y
H
A
P
L
G
---
A
I
M
G
----
D
W
----------------
P
A
P
D
N
S
-
A
K
----------------------------
I
V
A
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K
Y
T
G
E
T
K
S
N
S
L
--
D
-
I
Y
L
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P
F
Q
F
-
L
------
G
R
E
H
E
L
V
V
--
G
T
S
A
S
F
S
H
W
--------------
E
G
K
S
--
Y
W
N
---
L
-
R
N
-
Y
D
N
---
T
T
D
-
D
--------
F
I
--
N
-------
W
D
----
G
----------
D
I
G
--------------------------
K
P
------
D
W
G
T
P
S
Q
Y
I
----------
D
D
K
T
R
Q
L
G
S
Y
M
T
A
R
F
N
V
T
D
-
D
--
L
N
L
F
L
G
G
----
R
V
V
D
Y
R
V
T
G
L
N
-----
P
------------------------------------
T
I
R
E
--------
S
G
R
F
I
P
Y
V
G
A
V
Y
D
L
N
-
D
T
Y
S
V
Y
A
S
Y
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D
--
I
F
M
P
Q
D
S
W
Y
R
-------------------------
D
S
S
N
-
K
L
L
E
P
--
D
E
G
Q
N
Y
-
E
I
-
G
I
K
G
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--
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G
-------
R
L
N
T
S
L
A
Y
F
E
I
H
E
E
N
R
A
E
E
D
A
--------------
L
Y
N
S
KPTNPA----------------
I
T
Y
A
Y
K
-
G
I
K
-----
A
K
T
K
G
Y
-----
E
A
E
I
S
G
----
E
----
L
A
P------
G
W
Q
V
Q
A
--
G
Y
T
H
K
I
I
--------
R
D
D
S
-----------------------------------------------
G
K
-
K
---
V
S
T
W
-
E
P
Q
D
Q
L
S
L
Y
T
S
Y
K
F
K
G
AL--
D
K
L
T
V
------
G
G
G
A
R
W
Q
G
K
S
--
W
Q
M
------
V
Y
N
N
----------
P
-----------------------
R
S
R
-
W
E
K
F
S
Q
----
E
D
Y
-
W
L
V
D
L
M
A
R
Y
Q
I
T
------
D
K
-
L
S
A
S
V
N
--
V
N
N
V
F
D
K
T
Y
Y
T
N
I
G
F
Y
--------------------------------
T
S
A
S
Y
G
D
P
R
N
L
M
F
S
T
-------------------------------
R
W
D
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
Fugue
68.28
11%
-8
- C3 -
3CSL
6
?
A:
[113-865]
------------------------------------------------------------------------
N
D
W
V
Y
D
E
P
R
S
V
S
V
I
S
------------------------------------------------
R
E
Q
M
D
N
R
P
-
A
R
H
A
A
D
I
L
E
Q
------------------------
T
T
G
A
Y
S
-
S
V
S
-
Q
-----
Q
-
D
----
P
A
----
L
S
---
V
N
I
---
R
G
I
Q
---
D
Y--
G
------
R
--------------
V
N
M
N
I
D
G
M
-
R
Q
--------
N
F
Q
-
K
S
------
G
------------
H
GQR
N
---
G
T
M
----
Y
--
I
D
S
E
L
L
S
G
V
T
I
D
K
G
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T
G
G
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G
S
A
G
T
L
G
G
I
A
T
F
N
T
V
S
A
S
D
F
L
A
-
P
G
-
K
E
L
G
G
K
L
H
A
S
T
-
G
------
D
------
N
------
G
-
T
-
H
F
I
--------
G
-
S
G
I
L
A
L
G
N
---
E
T
G
D
I
L
L
A
A
S
E
R
H
--
L
G
--
D
Y
W
P
G
N
K
----
G
-
D
--------------------------------------
I
-------------
G
N
I
-
R
I
N
N
-
D
T
-
G
N
Y
D
R
Y
A
E
S
I
K
N
N
K
I
P
D
T
--
H
Y
-
R
M
H
S
R
L
A
K
V
G
W
N
----------------
L
P
A
N
Q
---------------
R
-----------------
L
--
Q
-
L
S
-
Y
L
Q
T
Q
T
-------------
A
S
P
I
A
G
-----
T
L
T
--
N
L
G
T
-
R
---
P
------
P
---
Y
E
L
------
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W
-
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A
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A
A
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L
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W
-
L
--
D
------------------------------
F
Q
--
A
K
L
Y
Y
V
D
T
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D
D
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D
T
Y
S
T
S
---
S
L
L
----------
D
N
G
Y
A
T
R
T
R
L
---
R
T
Y
G
A
Q
-
A
Q
---------------------
N
T
S
R
F
S
L
A
P
G
H
D
F
R
A
N
Y
G
L
E
F
Y
--
Y
-
D
K
A
T
S
D
S
S
--
R
------
Q
G
M
E
G
V
T
P
--
A
G
N
R
S
V
A
S
L
--------------
F
A
N
L
--
T
Y
D
Y
DG
W
-
L
T
-
L
E
G
G
--
L
R
Y
D
R
--------
Y
R
--
L
-------
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G
----
Q
----------
T
G
L
S
-
Y
P
D
--------------------
L
A
K
------
D
G
Q
R
Y
T
I
D
N
----------
P
C
K
A
L
R
L
T
G
C
S
T
T
T
R
E
D
W
D
-
V
--
D
R
D
Q
G
K
L
----
S
P
T
L
A
V
A
V
R
P
-------------------------------------------
G
V
E
W
--------
L
E
L
Y
T
T
Y
G
K
S
W
R
P
P
---------
A
I
T
E
--
T
L
T
N
G
S
A
H
S
S
S
--
T
Q
Y
P
-------
N
P--------
F
L
Q
P
E
-
R
S
R
A
W
--
E
V
G
F
N
V
-
Q
Q
P
D
L
W
F
E
--
G
-------
D
-------
R
L
V
A
K
V
A
Y
F
D
T
K
V
D
N
Y
I
N
L
A
I
--------------
D
RNKPG
L
V
Q
P
S
IG-------------
N
A
A
Y
V
N
N
L
S
K
-----
T
R
F
R
G
L
-----
E
Y
Q
L
N
Y
----
D
----
A
G
-------
V
F
Y
A
D
L
--
T
Y
T
H
M
I
G
--------
K
N
E
F
C
--
S
----
N
KAWLGG
R
-------------------------------
L
R
-
Y
---
G
D
G
S
-
R
R
G
N
F
Y
V
E
P
D
A
A
S
N
D
F
----
V
T
C
D
G
------
G
T
Q
F
G
S
A
A
Y
L
P
G
D
R
G
------
S
V
T
L
----------
G
G
R
A
F
D
R
K
L
D
A
G
V
T
V
R
F
A
--
P
G
Y
Q
D
S
S
-
V
P
S
N
Y
P
----
Y
L
A
-
D
W
P
K
Y
T
L
F
D
L
Y
A
S
Y
---
K
L
T
-
D
S
L
T
L
R
G
S
V
E
N
L
T
N
R
A
Y
---------------------------
V
---
V
--
S
Y
G
E
T
L
A
N
T
L
G
R
G
R
T
V
Q
G
G
V
-------------------------------
E
Y
R
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
HHSearch
67.87
13%
5
- C3 -
3QLB
3
?
A:
[100-748]
------------------------------------------------------------------------------------------------------
E
I
P
Q
S
I
S
V
-----------------------
I
T
R
D
Q
M
D
A
Q
Q
-
V
Q
S
V
N
E
A
L
R
Y
------------------------
T
A
G
V
Q
A
-
N
T
T
-
A
AS---
Q
-
R
----
F
-----
D
T
---
L
S
I
---
R
G
F
D
---
V
----------
T
--------------
T
G
M
L
R
D
G
L
-
K
G
--------
N
T
A
-
Q
----------------------------
A
W
P
----
K
--
V
E
A
Y
G
L
E
R
I
D
V
L
K
G
P
A
S
V
L
F
G
Q
N
S
P
G
G
V
V
N
Q
I
S
K
R
P
L
D
K
--------
P
F
H
E
V
Q
I
Q
G
-
G
------
S
------
F
------
D
-
R
-
A
Q
G
--------
Q
-
F
D
F
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G
-
P
L
DDE
G
Q
F
L
Y
R
L
V
G
L
E
R
D
--
S
G
--
T
Q
F
D
H
---------------------------------------------------------------------------
I
K
D
D
K
Q
Y
F
A
P
S
F
T
W
K
P
--
N
D
-
D
T
S
L
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L
L
A
D
Y
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Q
----------------
D
T
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G
A
---------------
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-----------------
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--
V
-
F
L
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A
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-------------
L
-
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N
P
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-----
G
K
V
----
R
H
N
V
---
F
-----------
L
D
------
E
P
---
G
L
D
N
D
R
T
Q
Y
S
L
G
Y
L
L
E
H
R
----
L
N
D
V
--
W
------------------------------
S
L
--
N
S
S
A
R
Y
G
H
V
N
L
L
T
N
T
------
A
S
G
------
M
----------------
S
L
A
P
D
L
-
R
T
----------------------
L
-
N
R
---
A
A
Y
R
F
R
I
V
G
D
T
Y
S
L
D
N
N
-
A
Q
A
R
W
N
L
G
---------
S
T
Q
M
V
S
L
L
--
G
I
D
Y
R
R
T
R
E
--------------
D
Y
Y
L
--
R
G
G
---
S
A
S
P
-
I
D
I
----------------
Y
N
--
P
-------
V
-----
H
----------
H
H
H
-------------------------
G
V
F
------
D
P
S
T
P
F
T
N
T
----------
V
Q
R
A
D
Q
V
G
V
Y
A
Q
Q
Q
F
T
F
D
E
-
H
--
W
V
L
T
V
G
G
----
R
Q
D
R
S
S
A
R
T
D
N
-----
R
MND
S
G
-------------------------------
S
K
Q
D
--------
D
E
K
F
T
Y
R
T
G
L
V
Y
L
A
D
-
N
G
L
A
P
Y
I
S
Y
S
T
--
S
F
D
P
V
L
G
T
N
F
Y
--------------------------
G
T
--
P
Y
K
P
--
T
S
A
K
Q
S
-
E
V
-
G
V
K
Y
Q
--
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-------
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GI-----
D
S
Y
I
T
L
S
L
F
D
L
T
Q
E
N
V
L
T
T
D
P
--------------
A
Q------------------------
R
L
N
K
I
Q
-
T
G
E
-----
I
N
V
R
G
I
-----
E
L
E
G
K
A
----
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----
L
A
R------
G
L
D
L
L
A
--
A
L
T
Y
N
D
A
--------
E
V
S
K
S
--
N
NP--
L
------
E
-------------------------------
K
G
-
K
---
R
P
T
D
-
T
P
E
K
M
A
S
L
W
A
D
Y
T
L
P
E
GPL-
S
G
L
G
F
------
G
A
G
V
R
Y
I
G
S
T
--
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A
D
------
A
-----------------------------------------
A
N
T
Q
R
V
----
P
S
Y
-
T
L
L
D
A
A
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H
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D
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L
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A
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G
-
L
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L
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--
A
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L
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K
H
Y
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E
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C
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L
---------------------------------
T
N
C
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A
G
Y
D
R
S
V
I
A
S
L
-------------------------------
R
Y
R
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
HHSearch
65.29
12%
-6
- C3 -
1KMO
17
FECA_ECOLI
A:
[114-774]
------------------------------------------------------------------------------------
A
L
T
V
V
G
D
W
L
GDAR
E
N
D
V
F
E
H
A
G
A
R
D
V
-----------------------
I
R
R
E
D
F
A
K
T
G
-
A
T
T
M
R
E
V
L
N
R
------------------------
I
P
G
V
S
A
-
P
E
N
-
N
-----
G
T
G
SHDL
A
-----
M
N
---
F
G
I
---
R
G
L
N
---
P
RLA
S
------
R
--------------
S
T
V
L
M
D
G
I
-
P
V
--------
P
F
A
-
P
Y
------
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------------
Q
---
P
QL-
S
L
A
----
P
--
V
S
L
G
N
M
D
A
I
D
V
V
R
G
G
G
A
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R
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G
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G
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V
N
F
V
T
R
A
I
P
Q
D
--------
F
G
I
E
A
G
V
E
G
-
Q
L
S
PTSS
Q
------
N
N
-----
P
-
K
-
E
T
H
--------
N
-
L
M
V
G
G
-
T
A
D--
N
G
F
G
T
A
L
L
Y
S
G
T
R
--
G
S
--
D
W
R
E
H
---------------------------------------------------------------------------
S
A
T
R
I
D
D
L
M
L
K
S
K
Y
A
P
--
D
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V
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S
L
L
Q
Y
Y
D
----------------
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E
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---------------
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-----------------
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--
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A
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-------------
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-----------------
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R
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---
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------
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----
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P
------
Y
D
-----
R
F
W
G
R
R
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L
A
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L
G
Y
Q
F
Q
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D
---
S
-
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--
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------------------------------
K
F
--
N
I
Q
G
F
Y
T
Q
T
L
---
R
---
S
---
G
Y
L
E
-
Q
G
-------------------
K
R
---
I
-
T
L
---------------------------------
S
P
R
N
Y
W
V
R
G
I
--
E
-
P
R
Y
S
Q
I
F
M
I-
G
------
P
S
A
H
E
V
G
V
--
G
Y
R
Y
L
N
E
S
T
--------------
H
E
M
R
--
Y
Y
T
---
A
----
T
S
S
--------------------
G
-------
Q
L
---------------
P
---------------------------
S
G
S
------
S
--
P
Y
D
R
D
T
----------
R
S
G
T
E
A
H
A
W
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-
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--
W
T
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----
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N
-----
A
ITG
T
H
-------------------------------
E
E
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--------
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A
---------------------
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--------------
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-------------------------
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--------
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-------------------------------
Y
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-
N
---
L
V
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------
N
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------
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N
T
----------
V
K
---------------------
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-
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----
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-
M
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---
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D
D
N
------------------------------
N
K
G
I
Y
A
G
Q
P
R
T
L
Y
M
Q
G
-------------------------------
S
L
K
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
Fugue
65.28
16%
20
- C3 -
4RDR
28
?
A:
[32-748]
-------------------------------------------
S
R
P
R
A
T
S
G
---------------
L
---
L
H
T
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T
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------------------------------
S
D
K
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-----------------------
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V
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--------
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------------------------------------------------------------
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--------------
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-------------
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M
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--------------------
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----------
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------------------------------------
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--------
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LNDGRGPKSIEDDS
E
M------------------------
K
L
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-----
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-------------------------------
S
L
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---
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D
T
P
Q
M
G
R
S
F
T
G
G
V
-------------------------------
N
V
K
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
Fugue
64.88
18%
-21
- C1 -
4CWU
-
CAPSH_ADE05
A:
[6-947]
-------------------------------------------
M
M
P
Q
W
S
Y
M
HISGQDASEYLSPGL
V
Q
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A
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E
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---------
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T
T
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R
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R
-----------------------
L
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R
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-----
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-
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----
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-----
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---
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---
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--------------
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-
A
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--------
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------------
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---
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-------------
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---
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--------------
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N
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------
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----------
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--
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------------------------------------
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--------------
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-------------------------
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----
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M
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---
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---
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T
L
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RGVIE
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PFSA-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
Fugue
64.79
11%
3
- C3 -
1KMO
17
FECA_ECOLI
A:
[114-774]
---------------------------------------------------------------------------
A
L
T
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V
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D
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G
D
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D
V
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---------
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H
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A
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-----------------------
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---
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--------------
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---
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--------------------------------------------------------------------------------------------------
G
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-------------
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-------------
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Y
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--------------
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---
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-----------------------------------------------------
S
-
S
G
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--------------------
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------
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D
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----------
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K
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----
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----
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H
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Y
Q
N
N
AITG
T
H
------------------------------------
E
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--------
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A
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N
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T
W
-
E
L
-
G
T
R
Y
D
--
D
-------
G
-------
A
L
T
A
E
M
G
L
F
L
I
N
F
N
N
Q
Y
D
S
N
Q
--------------
T
-------------------------
N
-----------------
D
T
V
-----
T
A
R
G
K
T
----
R
----
H
T
-------
G
L
E
T
Q
A
--
R
Y
D
L
G
T
L
-----------
T
P
--
T
----
L
------
D
-------------------------------
N
V
-
S
---
I
Y
A
S
-
Y
A
Y
V
N
A
E
I
R
E
K
G
D
T
Y
G
----
N
L
V
P
F
------
S
P
K
H
K
G
T
L
G
V
--
D
Y
K
------
P
G
N
W
----------
T
F
N
L
N
S
D
F
Q
S
S
Q
F
A
D
N
A
N
--
T
V
K
E
S
A
D
-
G
S
T
G
R
I
----
P
G
F
-
M
L
W
G
A
R
V
A
Y
D
F
G
P
Q
---
M
---
A
D
L
N
L
A
F
G
V
K
N
I
F
D
Q
D
Y
F
I
R
S
Y
D
D
N
--------
N
K
---
G
-
I
---
Y
---
A
--
G
----------
Q
P
R
T
L
Y
M
Q
G
-------------------------------
S
L
K
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
HHSearch
63.61
13%
8
- C3 -
1XKW
11
FPTA_PSEAE
A:
[5-665]
--------------------------------------------------------------------------------
A
T
Q
P
P
G
V
T
T
L
G
K
V
PLKPR----
E
L
P
Q
S
A
S
V
-----------------------
I
D
H
E
R
L
E
Q
Q
N
-
L
F
S
L
D
E
A
M
Q
Q
------------------------
A
T
G
V
T
V
-
Q
P
F
-
Q
-----
L
-
L
----
T
-----
T
A
---
Y
Y
V
---
R
G
F
K
---
V
---
D
----------------------
S
F
E
L
D
G
V
-
P
A
--------
L
L
G
-
N
T
---------------------------
A
S
S
----
P
--
Q
D
M
A
I
Y
E
R
V
E
I
L
R
G
S
N
G
L
L
H
G
T
G
N
P
A
A
T
V
N
L
V
R
K
R
P
Q
R
--------
E
F
A
A
S
T
T
L
S
A
-
G
------
R
------
W
------
D
-
R
-
Y
R
A
--------
E
-
V
D
V
G
G
-
P
L
SAS
G
N
V
R
G
R
A
V
A
A
Y
E
D
--
R
D
--
Y
F
Y
D
V
A
---------------------------------------------------------------------------
D
Q
G
T
R
L
L
Y
G
V
T
E
F
D
L
--
S
P
-
D
T
L
L
T
V
G
A
Q
Y
Q
H
----------------
I
D
S
I
T
---------------
N
-----------------
M
--
A
G
V
P
-
M
A
-
K
D
G
-------------
S
N
L
G
-------
L
S
-----
R
D
T
Y
---
L
------
D
----
V
D
------
W
D
-----
R
F
K
W
D
T
Y
R
A
F
G
S
L
E
Q
Q
L
G
---
G
-
G
--
W
------------------------------
K
G
--
K
V
S
A
E
Y
Q
E
A
D
S
R
L
R
Y
A
-
G
---
S
F
G
-----------------------
A
I
D
P
-
Q
-
T
G
---------------------
D
G
-
G
Q
L
M
G
A
A
Y
K
F
K
S
I
Q
R
S
L
D
A
--
N
-
L
N
G
P
V
R
L
---
F
------
G
L
T
H
E
L
L
G
--
G
V
T
Y
A
Q
G
E
T
--------------
R
Q
D
T
--
A
R
F
---
L
--
N
-
L
P
N
----
T
P
-
V
---------
N
--
V
-------
Y
R
----
W
----------
D
P
H
G
---
V
--------------------
P
R
P
------
Q
I
G
Q
Y
T
S
P
G
----------
T
T
T
T
T
Q
K
G
L
Y
A
L
G
R
I
K
L
A
E
-
P
--
L
T
L
V
V
G
G
----
R
E
S
W
W
D
Q
D
T
P
A
-----
T
------------------------------------
R
F
K
P
--------
G
R
Q
F
T
P
Y
G
G
L
I
W
D
F
A
-
R
D
W
S
W
Y
V
S
Y
A
E
--
V
Y
Q
P
-------------------------------------
P
L
S
P
--
V
E
G
K
T
Y
-
E
T
-
G
I
K
G
E
--
L
AD-----
G
-------
R
L
N
L
S
L
A
A
F
R
I
D
L
E
N
N
P
Q
E
D
P
--------------
D
HPGPPN-------------------
N
P
F
Y
I
S
-
G
G
K
-----
V
R
S
Q
G
F
-----
E
L
E
G
T
G
----
Y
----
L
T
P------
Y
W
S
L
S
A
--
G
Y
T
Y
T
S
T
--------
E
Y
L
K
D
--
S
----
Q
N-----
D
-------------------------------
S
G
T
R
---
Y
S
T
F
-
T
P
R
H
L
L
R
L
W
S
N
Y
D
L
P
W
QD--
R
R
W
S
V
------
G
G
G
L
Q
A
Q
S
D
Y
--
S
V
D
------
Y
R
----------------------------------------
G
V
S
M
R
Q
----
G
G
Y
-
A
L
V
N
M
R
L
G
Y
K
I
D
------
E
H
-
W
T
A
A
V
N
--
V
N
N
L
F
D
R
T
Y
Y
Q
S
L
S
N
P
N
-------------------------------
W
N
N
R
Y
G
E
P
R
S
F
N
V
S
L
-------------------------------
R
G
A
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
HHSearch
61.53
13%
-12
- C3 -
2GUF
16
BTUB_ECOLI
A:
[2-594]
-------------------------------------------------------------------------------
D
T
S
P
D
T
L
V
V
T
A
N
R
F
E
Q
P
RS----
T
V
L
A
P
T
T
V
-----------------------
V
T
R
Q
D
I
D
R
W
Q
-
S
T
S
V
N
D
V
L
R
R
------------------------
L
P
G
V
D
I
-
T
-----------
Q
----
L
-----
S
S
---
I
F
I
---
R
G
T
N
---
A
---
S
------
H
--------------
V
L
V
L
I
D
G
V
-
R
L
--------
N
L
A
-
G
V
S-----
G
------------
S
---
A
---
D
L
S
----
Q
--
F
P
I
A
L
V
Q
R
V
E
Y
I
R
G
P
R
S
A
V
Y
G
S
D
A
I
G
G
V
V
N
I
I
T
T
R
D
E
P
----------
G
T
E
I
S
A
G
W
-
G
------
S
------
N
------
S
-
Y
-
Q
N
Y
--------
D
-
V
S
T
Q
Q
-
Q
L
G--
D
K
T
R
V
T
L
L
G
D
Y
A
H
--
T
H
----------------------------------------------------------------------------------
D
G
F
L
S
K
T
L
Y
G
A
L
E
H
N
F
--
T
D
-
A
W
S
G
F
V
R
G
Y
G
Y
D
----------------
N
R
T
N
Y
--------------------------------------------------------------------------------------------------
D
------
T
R
-----
K
L
Y
S
Q
S
W
D
A
G
L
R
Y
N
G
E
----
L
-----
I
------------------------------
K
S
--
Q
L
I
T
S
Y
S
H
S
K
D
-
Y
N
Y
--
D
---
P
H
Y
-----------------------
G
---
R
Y
-
D
S
-------------------------------
S
A
T
L
D
E
M
K
Q
Y
T
V
--
Q
-
W
A
N
N
V
I
V
-----------
G
H
G
S
I
G
A
--
G
V
D
W
Q
K
Q
T
T
--------------
T
P
G
T
--
G
----------------------------------------------------------------------------------------------------
Y
V
E
D
----------
G
Y
D
Q
R
N
T
G
I
Y
L
T
G
L
Q
Q
V
G
--
D
--
F
T
F
E
G
A
A
----
R
S
D
D
N
S
Q
F
---------------------------------------------------------
G
R
H
G
T
W
Q
T
S
A
G
W
E
F
I
-
E
G
Y
R
F
I
A
S
Y
G
T
--
S
Y
K
A
P
N
L
G
Q
L
Y
--
G
F
---------------------
Y
G
N
-
P
N
L
D
P
--
E
K
S
K
Q
W
-
E
G
-
A
F
E
G
L
--
T
-------
A
-------
G
V
N
W
R
I
S
G
Y
R
N
D
V
S
D
L
I
D
Y
D
D
--------------
H
-------------------------
T
L
K
Y
Y
N
-
E
G
K
-----
A
R
I
K
G
V
-----
E
A
T
A
N
F
----
D
----
T
G
-------
P
L
T
H
T
V
--
S
Y
D
Y
V
D
A
--------
R
N
A
I
-----------------------------------------------
T
D
-
T
---
P
L
L
R
-
R
A
K
Q
Q
V
K
Y
Q
L
D
W
Q
L
Y
------
D
F
D
W
------
G
I
T
Y
Q
Y
L
G
T
R
--
Y
D
K
------
D
Y
S
S
-----------------------------------
Y
P
-
Y
Q
T
V
K
M
----
G
G
V
-
S
L
W
D
L
A
V
A
Y
P
V
T
------
S
H
-
L
T
V
R
G
K
--
I
A
N
L
F
D
K
D
Y
---------------------------------------------
A
G
R
E
Y
T
L
S
G
-------------------------------
S
Y
T
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
60.27
21%
-25
- C3 -
4B7O
-
?
A:
[354-745]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
H
T
R
I
T
T
R
G
M
--
N
-
F
N
F
D
S
R
L
A
--
E
------
Q
T
--
L
L
K
Y
--
G
I
N
Y
R
H
Q
E
I
K
P
QAFLNGEFEIS--------------------
T
D
--
E
E
K
A
K
--------
D
K
--
K
-------
D
M
----
D
----------
L
V
H
S
-
Y
K
L
--------------------
S
N
P
------
T
K
T
D
T
---------------------
G
A
Y
I
E
A
---
I
H
E
-
L
DG
F
T
L
T
G
G
L
----
R
Y
D
R
F
K
V
K
T
H
D
-----
G
------------------------------------
K
T
V
S
--------
S
S
N
L
N
P
S
F
G
V
I
W
Q
P
H
-
E
H
W
S
F
S
S
S
H
N
Y
--
A
S
R
S
P
R
L
Y
D
A
L
QT
H
G
K
R
-------
G
---------
I
I
S
I
A
-
D
G
T
K
A
--
E
R
A
R
N
T
-
E
I
-
G
F
N
Y
N
--
D
-------
G
-------
T
F
A
A
N
G
S
Y
F
W
Q
T
I
K
D
A
L
A
N
P
Q
--------------
N
------------------------------
A
V
R
E
A
V
NA
G
Y
I
K
N
H
G
Y
-----
E
L
G
A
S
Y
----
R
----
T
G
-------
G
L
T
A
K
V
--
G
V
S
H
S
K
P
R
F
Y
D
----
T
H
P
K
K
--
L
----
L
------
S
-------------------------------
A
N
-
P
---
E
F
G
A
-
Q
V
G
R
A
W
T
A
S
L
A
Y
R
F
Q
N
----
P
N
L
E
I
------
G
W
R
G
R
Y
V
------------------------------------
Q
K
A
V
G
S
I
L
V
A
--
G
Q
K
D
R
--K
L
E
N
V
V
R
----
K
G
F
-
G
V
N
D
V
F
A
N
W
K
P
L
G
K
---
D
T
----
L
N
V
N
L
S
V
N
N
V
F
N
T
F
Y
Y
P
H
S
Q
R
W
T
--------
N
T
---------
L
---
P
--
G
V
----------
G
R
D
V
R
L
G
V
-------------------------------
N
Y
K
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
HHSearch
60.17
13%
15
- C3 -
1FEP
-
FEPA_ECOLI
A:
[11-724]
----------------------------------------------------------------------------------
D
D
T
I
V
V
T
A
A
E
Q
N
--------
L
Q
A
P
G
V
S
T
-----------------------
I
T
A
D
E
I
R
K
N
P
V
A
R
D
V
S
K
I
I
R
T
------------------------
M
P
G
V
N
L
-
T
G
N
-
S
TSGQR
G
-
N
----
N
-----
R
Q
---
I
D
I
---
R
G
M
G
---
P
---
E
------
N
--------------
T
L
I
L
I
D
G
K
-
P
V
--------
S
S
R
-
N
S
------
V
RQGWRGERDT--
R
---
G
---
D
T
S
----
W
--
V
P
P
E
M
I
E
R
I
E
V
L
R
G
P
A
A
A
R
Y
G
N
G
A
A
G
G
V
V
N
I
I
T
K
K
G
S
G
--------
E
W
H
G
S
W
D
A
Y
F
-
N
------
A
P
EHKE
E
G
------
A
-
T
-
K
R
T
--------
N
-
F
S
L
T
G
-
P
L
G--
D
E
F
S
F
R
L
Y
G
N
L
D
K
T
Q
A
D
--
A
W
D
I
N
Q
G
H
--
Q
S
-
A
--------------------------------------
R
-------------
A
G
T
-
Y
A
T
T
L
P
A
-
G
R
E
G
V
I
N
K
D
I
N
G
V
V
R
W
D
F
--
A
P
-
L
Q
S
L
E
L
E
A
G
Y
S
R
----------------
Q
G
N
L
Y
---------------
A
-----------------
G
--
D
-
T
Q
-
N
T
---
N
-------------
S
---
D
S
-----
Y
------
T
R
S
K
---
Y
-----------
G
D
------
E
T
------
N
R
L
Y
R
Q
N
Y
A
L
T
W
N
G
G
----
W
--
D
--
N
------------------------------
G
V
--
T
T
S
N
W
V
Q
Y
E
H
--
T
R
---
N
---
S
R
I
P
---
E
G
L
A
-------
G
----------------------------------------------
Q
D
F
V
D
I
D
L
D
D
V
M
L
--
H
-
S
E
V
N
L
P
I
D
--
F
------
L
V
N
Q
T
L
T
L
--
G
T
E
W
N
Q
Q
R
M
--------------
K
D
L
S
--
S
N
T
---
Q
--
A
-------------------------------------------------------------------------------------------
D
R
S
P
----------
Y
S
K
A
E
I
F
S
L
F
A
E
N
N
M
E
L
T
D
-
S
--
T
I
V
T
P
G
L
----
R
F
D
H
H
S
I
V
---------------------------------------------------------
G
N
N
W
S
P
A
L
N
I
S
Q
G
L
G
-
D
D
F
T
L
K
M
G
I
A
R
--
A
Y
K
A
P
S
L
Y
Q
T
N
--
P
N
Y
I
L
Y
S
KGQG
C
---------
Y
L
Q
G
N
-
D
D
L
K
A
--
E
T
S
I
N
K
-
E
I
-
G
L
E
F
K
--
R
-------
D
-------
G
W
L
A
G
V
T
W
F
R
N
D
Y
R
N
K
I
E
A
G
Y
--------------
V
AVGQNAVG
T
D
---------------
L
Y
Q
W
D
N
-
V
P
K
-----
A
V
V
E
G
L
-----
E
G
S
L
N
V
----
P
----
V
S
E------
T
V
M
W
T
N
--
N
I
T
Y
M
L
K
--------
S
E
N
K
---------------
T
-------------------------------
T
G
-
D
---
R
L
S
I
-
I
P
E
Y
T
L
N
S
T
L
S
W
Q
A
R
-----
E
D
L
S
M
------
Q
T
T
F
T
W
Y
G
K
Q
--
Q
P
K
------
K
Y
N
Y
----------
K
--------------
G
------
Q
P
A
V
G
-
P
E
T
K
E
I
----
S
P
Y
-
S
I
V
G
L
S
A
T
W
D
V
T
------
K
N
-
V
S
L
T
G
G
--
V
D
N
L
F
D
K
R
L
W
R
A
G
N
A
Q
T
--------
T
G
---
D
L
A
---
G
---
A
N
Y
I
A
G
A
G
A
Y
T
Y
N
E
P
G
R
T
W
Y
M
S
V
-------------------------------
N
T
H
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
58.77
21%
-20
- C3 -
4AIQ
2
?
A:
[354-745]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
H
T
R
I
T
T
R
G
M
--
N
-
F
N
F
D
S
R
L
A
--
E
------
Q
T
--
L
L
K
Y
--
G
I
N
Y
R
H
Q
E
I
K
P
QAFLNGE
F
E
I
S
G------------------------
E
K
A
K
--------
D
K
--
K
-------
D
M
----
D
----------
L
V
H
S
-
Y
K
L
--------------------
S
N
P
------
T
K
T
D
T
---------------------
G
A
Y
I
E
A
---
I
H
E
-
L
DG
F
T
L
T
G
G
L
----
R
Y
D
R
F
K
V
K
T
H
D
-----
G
------------------------------------
K
T
V
S
--------
S
S
N
L
N
P
S
F
G
V
I
W
Q
P
H
-
E
H
W
S
F
S
S
S
H
N
Y
--
A
S
R
S
P
R
L
Y
D
A
L
QT
H
G
K
R
-------
G
---------
I
I
S
I
A
-
D
G
T
K
A
--
E
R
A
R
N
T
-
E
I
-
G
F
N
Y
N
--
D
-------
G
-------
T
F
A
A
N
G
S
Y
F
W
Q
T
I
K
D
A
L
A
N
P
Q
--------------
N
-------------------------
R
H
V
S
A
A
V
R
E
A
V
NA
G
Y
I
K
N
H
G
Y
-----
E
L
G
A
S
Y
----
R
----
T
G
-------
G
L
T
A
K
V
--
G
V
S
H
S
K
P
R
F
Y
D
----
T
H
P
K
K
--
L
----
L
------
S
-------------------------------
A
N
-
P
---
E
F
G
A
-
Q
V
G
R
A
W
T
A
S
L
A
Y
R
F
Q
N
----
P
N
L
E
I
------
G
W
R
G
R
Y
V
------------------------------------
Q
K
A
V
G
S
I
L
V
A
--
G
Q
K
D
R
--K
L
E
N
V
V
R
----
K
G
F
-
G
V
N
D
V
F
A
N
W
K
P
L
G
K
---
D
T
----
L
N
V
N
L
S
V
N
N
V
F
N
T
F
Y
Y
P
H
S
Q
R
W
T
--------
N
T
---------
L
---
P
--
G
V
----------
G
R
D
V
R
L
G
V
-------------------------------
N
Y
K
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------