@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_0821: (2015-12-18 )
MVLEVKNLSFKYSQKLILDKLSFSVPKNSITSILAPNGSGKTTLLKCLLGLLKPLEETEIKACNKDILPLKPYEKAKLIAYIPQVEYYAFNFSVLDFVLMGKATHLNLFAMPKAKHIKEATSVLERLDLESLKDQGINDLSGGQRQMVLLARSLLQRTPLLLLDEPTSALDLKNQALFFDAIKDEMKKRELSVLVNIHDPNLVARHSTHVVMLKDKKLFLQASTPIAMTSHNLSALYDTPLEAIWHDDKLVVYAL
Atome Classification :
(20 SA)
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------..-.......10.--.----.---..-...20........30........40........50.-------..------.....60.......---.70-.---.......-.80......--..90........100----.....-.-----.110-......-...120....---..--.130-----------.......140.......150....-----...-160.......170----.........180......-.190.......200.......210.......220.......230.......------240.....-----------------..250...-------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
V
-
L
E
VKNLS
F
K
Y
--
S
----
Q
---
K
L
-
I
L
D
K
LSFSVPKN
S
I
T
S
I
LAPNGS
G
K
T
T
L
L
K
C
L
L
G
L
L-------KP------
L
E
E
T
E
I
K
ACNKDIL---PL--K---PYEK
A
K
L
-
I
A
Y
IPQ
V
E
Y
--
Y
A
F
N
F
S
V
L
D
F
V
LMGK----A
T
H
L
N
-
L
-----
F
A---M
P
K
A
K
H
-
I
K
E
A
T
S
V
L
E
R
---
L
D
--
L
E
S
L
-----------
K
DQGINDLSGG
Q
R
Q
M
V
L
L
A
R
S
L
L
Q
-----RT
P
-
L
L
L
LDEPTSAL------DLKNQ
A
L
F
F
D
A
I
K
D
E
M
K
K
-R
E
L
S
V
L
V
N
IHDPN
L
V
A
RHS
T
H
V
V
M
L
KD
K
K
L
F
L
QAST
P
I
A
M
TSH
N
L
S
A
L
Y
DT------
P
L
E
A
IWHD-----------------
D
K
L
V
V
Y
AL-------------------------------------------------------------------------------------------
65
HHSearch
86.94
38%
-119
- C1 -
2NQ2
-
Y1470_HAEIN
C:
[4-228]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-
L
S
V
E
N
L
G
F
Y
Y
--
Q
----
A
E--
N
F
-
L
F
Q
Q
L
N
F
D
L
N
K
G
D
I
L
A
V
L
G
Q
N
G
C
G
K
S
T
L
L
D
L
L
L
G
I
H
-------
R
P
------
I
Q
-
G
K
I
E
V
---------------------
Y
Q
S
-
I
G
F
V
P
Q
F
F
S
--
S
P
F
A
Y
S
V
L
D
I
V
L
M
G
R
----
S
T
H
I
N
-
T
-----
F
A
---
K
P
K
S
H
D
-
Y
Q
V
A
M
Q
A
L
D
Y
---
L
N
--
L
T
H
L
-----------
A
K
R
E
F
T
S
L
S
G
G
Q
R
Q
L
I
L
I
A
R
A
I
A
S
-----
E
C
K
-
L
I
L
L
D
E
P
T
S
A
L
------
D
L
A
N
Q
D
I
V
L
S
L
L
I
D
L
A
Q
S
-
Q
N
M
T
V
V
F
T
T
H
Q
P
N
Q
V
V
A
I
A
N
K
T
L
L
L
N
K
Q
N
F
-
K
F
G
E
T
R
N
I
L
T
S
E
N
L
T
A
L
F
H
L
------
P
M
F
E
Q
Q
A
Q
-----------------
Y
K
E
S
F
F
T
H
-------------------------------------------------------------------------------------------
1
PsiBlast_PDB
82.18
36%
-111
- C1 -
2NQ2
-
Y1470_HAEIN
C:
[5-229]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
V
E
N
L
G
F
Y
Y
Q-
A
----
E
---
N
F
-
L
F
Q
Q
L
N
F
D
L
N
K
G
D
I
L
A
V
L
G
Q
N
G
C
G
K
S
T
L
L
D
L
L
L
G
I
H
-------
R
P
------
I
Q
-------------------
G
---
K
I
E
V
Y
Q
S
-
I
G
F
V
P
Q
F
F
S
--
S
P
F
A
Y
S
V
L
D
I
V
L
M
G
R
----
S
T
H
I
N
-
T
-----
F
A
---
K
P
K
S
H
D
-
Y
Q
V
A
M
Q
A
L
D
Y
---
L
N
--
L
T
H
L
-----------
A
K
R
E
F
T
S
L
S
G
G
Q
R
Q
L
I
L
I
A
R
A
I
A
S
-----
E
C
K
-
L
I
L
L
D
E
P
T
S
A
L
------
D
L
A
N
Q
D
I
V
L
S
L
L
I
D
L
A
Q
S
-
Q
N
M
T
V
V
F
T
T
H
Q
P
N
Q
V
V
A
I
A
N
K
T
L
L
L
-
N
K
Q
N
F
K
F
G
E
T
R
N
I
L
T
S
E
N
L
T
A
L
F
H
L
------
P
M
F
E
Q
Q
A
Q
-----------------
Y
K
E
S
F
F
T
H
-------------------------------------------------------------------------------------------
12
PsiBlast_PDB
76.59
28%
-115
- C1 -
1G9X
4
LIVG_METJA
A:
[7-235]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
-
L
R
T
E
N
I
V
K
Y
F
--
G
----
E
---
F
K
-
A
L
D
G
V
S
I
S
V
C
K
G
D
V
T
L
I
I
G
P
N
G
S
G
K
S
T
L
I
N
V
I
T
G
F
L
-------
K
A
-------
D
E
G
R
V
Y
F
E
N
K
D
I
T
---
N
K
--
E
---
P
A
E
L
Y
H
Y
G
I
V
R
T
F
Q
T
P
Q
--
P
L
K
E
M
T
V
L
E
N
L
L
I
G
E
INPG
E
S
P
L
N
S
L
-----
F
Y
KKW
I
P
K
E
E
E
M
V
E
K
A
F
K
I
L
E
F
---
L
K
--
L
S
H
L
-----------
Y
D
R
K
A
G
E
L
S
G
G
Q
M
K
L
V
E
I
G
R
A
L
M
T
-----
N
P
K
-
M
I
V
M
D
E
P
I
A
G
V
A
P
G
L
A
H
D
I
F
N
H
V
L
-------
E
L
K
A
-
K
G
I
T
F
L
I
I
E
H
R
L
D
I
V
L
N
Y
I
D
H
L
Y
V
M
F
N
G
Q
I
I
A
E
G
R
G
E
E
E
I
K
N
V
L
S
D
P
K
V
V
E
------
I
Y
I
G
------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
76.07
28%
-122
- C1 -
1G6H
3
LIVG_METJA
A:
[7-235]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
-
L
R
T
E
N
I
V
K
Y
F
--
G
----
E
---
F
K
-
A
L
D
G
V
S
I
S
V
N
K
G
D
V
T
L
I
I
G
P
N
G
S
G
K
S
T
L
I
N
V
I
T
G
F
L
-------
K
A
-------
D
E
G
R
V
Y
F
E
N
K
D
I
T
---
N
K
--
E
---
P
A
E
L
Y
H
Y
G
I
V
R
T
F
Q
T
P
Q
--
P
L
K
E
M
T
V
L
E
N
L
L
I
G
E
I
C
PG
E
S
P
L
N
S
L
-----
F
Y
KKW
I
P
K
E
E
E
M
V
E
K
A
F
K
I
L
E
F
---
L
K
--
L
S
H
L
-----------
Y
D
R
K
A
G
E
L
S
G
G
Q
M
K
L
V
E
I
G
R
A
L
M
T
-----
N
P
K
-
M
I
V
M
D
E
P
I
A
G
V
A
P
G
L
A
H
D
I
F
N
H
V
L
-------
E
L
K
A
-
K
G
I
T
F
L
I
I
E
H
R
L
D
I
V
L
N
Y
I
D
H
L
Y
V
M
F
N
G
Q
I
I
A
E
G
R
G
E
E
E
I
K
N
V
L
S
D
P
K
V
V
E
------
I
Y
I
G
E
-----------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
75.51
28%
-108
- C1 -
4G1U
1
HMUV_YERPE
C:
[11-256]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
-
L
E
A
S
H
L
H
Y
H
V
--
Q
----
Q
---
Q
A
-
L
I
N
D
V
S
L
H
I
A
S
G
E
M
V
A
I
I
G
P
N
G
A
G
K
S
T
L
L
R
L
L
T
G
Y
L
-------
S
P
-------
S
H
G
E
C
H
L
L
G
Q
N
L
N
---
S
W
--
Q
---
P
K
A
L
A
R
T
-
R
A
V
M
R
Q
Y
S
E
--
L
A
F
P
F
S
V
S
E
V
I
Q
M
G
R
----
A
P
Y
G
G
---------------
S
Q
D
-
R
Q
A
L
Q
Q
V
M
A
Q
---
T
D
--
C
L
A
L
-----------
A
Q
R
D
Y
R
V
L
S
G
G
E
Q
Q
R
V
Q
L
A
R
V
L
A
Q
L
WQPQ
P
T
P
R
W
L
F
L
D
E
P
T
S
A
L
------
D
L
Y
H
Q
Q
H
T
L
R
L
L
R
Q
L
T
R
Q
-
E
P
L
A
V
C
C
V
L
H
D
L
N
L
A
A
L
Y
A
D
R
I
M
L
L
A
Q
G
K
L
V
A
C
G
T
P
E
E
V
L
N
A
E
T
L
T
Q
W
Y
Q
A
------
D
L
G
V
S
R
H
P
-----------------
E
S
A
L
P
Q
I
Y
-------------------------------------------------------------------------------------------
58
HHSearch
74.61
27%
-110
- C1 -
3GFO
1
ECFA3_CLOP1
A:
[7-236]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
-
L
K
V
E
E
L
N
Y
N
Y
--
S
----
D
G--
T
H
-
A
L
K
G
I
N
M
N
I
K
R
G
E
V
T
A
I
L
G
G
N
G
V
G
K
S
T
L
F
Q
N
F
N
G
I
L
-------
K
P
------
S
S
-
G
R
I
L
F
D
N
K
P
I
D
---
Y
S
R
K
G
---
I
M
K
L
R
E
S
-
I
G
I
V
F
Q
D
P
D
N-
Q
L
F
S
A
S
V
Y
Q
D
V
S
F
G
A
----
V
N
M
K
-------------
L
P
E
D
E
I
-
R
K
R
V
D
N
A
L
K
R
---
T
G
--
I
E
H
L
-----------
K
D
K
P
T
H
C
L
S
F
G
Q
K
K
R
V
A
I
A
G
V
L
V
M
-----
E
P
K
-
V
L
I
L
D
E
P
T
A
G
L
------
D
P
M
G
V
S
E
I
M
K
L
L
V
E
M
Q
K
E
-
L
G
I
T
I
I
I
A
T
H
D
I
D
I
V
P
L
Y
C
D
N
V
F
V
M
K
E
G
R
V
I
L
Q
G
N
P
K
E
V
F
A
E
K
E
V
I
R
K
V
N
L
------
R
L
P
R
I
G
H
L
-----------------
M
E
I
------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
73.64
31%
-101
- C1 -
3D31
-
?
A:
[1-222]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
-
I
E
I
E
S
L
S
R
K
W
-------
K
---
N
F
-
S
L
D
N
L
S
L
K
V
E
S
G
E
Y
F
V
I
L
G
P
T
G
A
G
K
T
L
F
L
E
L
I
A
G
F
H
-------
V
P
-------
D
S
G
R
I
L
L
D
G
K
D
V
T
---
D
L
--
S
---
P
-
E
K
H
D
--
I
A
F
V
Y
Q
--------
N
Y
S
L
F
------------
P
H
M
N
-
V
K
K
N
L
E
F
G
---
M
-
R
M
K
K
-
I
K
D
P
K
R
V
L
D
T
A
R
D
L
K
--
I
E
H
L
-----------
L
D
R
N
P
L
T
L
S
G
G
E
Q
Q
R
V
A
L
A
R
A
L
V
T
-----
N
P
K
-
I
L
L
L
D
E
P
L
S
A
L
------
D
P
R
T
Q
E
N
A
R
E
M
L
S
V
L
H
K
K
-
N
K
L
T
V
L
H
I
T
H
D
Q
T
E
A
R
I
M
A
D
R
I
A
V
V
M
D
G
K
L
-
I
Q
V
G
K
P
--------
E
E
I
F
E
K
------
P
V
E
G
R
V
A
S
-----------------
F
V
G
F
E
N
V
L
-------------------------------------------------------------------------------------------
14
PsiBlast_PDB
73.33
27%
-111
- C1 -
1GAJ
6
LIVG_METJA
A:
[7-235]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
-
L
R
T
E
N
I
V
K
Y
F
--
G
----
E
---
F
K
-
A
L
D
G
V
S
I
S
V
N
K
G
D
V
T
L
I
I
G
P
N
G
S
G
K
S
T
L
I
N
V
I
T
G
F
L
-------
K
A
-------
D
E
G
R
V
Y
F
E
N
K
D
I
T
---
N
K
--
E
---
P
A
E
L
Y
H
Y
G
I
V
R
T
F
Q
T
P
Q
--
P
L
K
E
M
T
V
L
E
N
L
L
I
G
E
INPG
E
S
P
L
N
S
L
-----
F
Y
KKW
I
P
K
E
E
E
M
V
E
K
A
F
K
I
L
E
F
---
L
K
--
L
S
H
L
-----------
Y
D
R
K
A
G
E
L
S
G
G
Q
M
K
L
V
E
I
G
R
A
L
M
T
-----
N
P
K
-
M
I
V
M
D
Q
P
I
A
G
V
A
P
G
L
A
H
D
I
F
N
H
V
L
-------
E
L
K
A
-
K
G
I
T
F
L
I
I
E
H
R
L
D
I
V
L
N
Y
I
D
H
L
Y
V
M
F
N
G
Q
I
I
A
E
G
R
G
E
E
E
I
K
N
V
L
S
D
P
K
V
V
E
------
I
Y
I
G
E
-----------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
71.82
26%
-107
- C1 -
3GFO
1
ECFA3_CLOP1
A:
[7-227]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
-
L
K
V
E
E
L
N
Y
N
Y
--
S
----
D
---
G
T
H
A
L
K
G
I
N
M
N
I
K
R
G
E
V
T
A
I
L
G
G
N
G
V
G
K
S
T
L
F
Q
N
F
N
G
I
L
-------
K
P
S
S
G
R
I
L
F
D
N
K
P
I
D
Y
S
R
K
G
I
M
---
K
L
--
R
-----
E
S
I
G
I
-
V
F
Q
D
P
D
N
Q
L
----
F
S
A
S
V
Y
Q
D
V
S
F
G
A
----
V
N
----------
M
K
---
L
P
E
D
E
I
-
R
K
R
V
D
N
A
L
K
R
---
T
G
--
I
E
H
L
-----------
K
D
K
P
T
H
C
L
S
F
G
Q
K
K
R
V
A
I
A
G
V
L
V
M
-----
E
P
K
-
V
L
I
L
D
E
P
T
A
G
L
------
D
P
M
G
V
S
E
I
M
K
L
L
V
E
M
Q
K
E
-
L
G
I
T
I
I
I
A
T
H
D
I
D
I
V
P
L
Y
C
D
N
V
F
V
M
K
E
G
R
V
I
L
Q
G
N
P
K
E
V
F
A
E
K
E
V
I
R
K
V
N
L
------
R
L
P
R
I
G
H
L
-----------------
M
E
I
------------------------------------------------------------------------------------------------
44
Fugue
70.44
26%
-98
- C1 -
1OXS
23
?
C:
[1-352]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
V
R
I
I
V
K
N
V
S
K
V
F
--
K
KG--
K
---
V
V
-
A
L
D
N
V
N
I
N
I
E
N
G
E
R
F
G
I
L
G
P
S
G
A
G
K
T
T
F
M
R
I
I
A
G
L
--------
D
V
------
P
S
T
G
E
L
Y
F
D
D
R
L
V
A
SNG
K
L
--
I
---
V
P
P
E
D
R
K
-
I
G
M
V
F
Q
T
W
A
--
L
Y
P
N
L
T
A
F
E
N
I
--------
A
F
P
L
T
-
N
-----
M
K
---
M
S
K
E
E
I
-
R
K
R
V
E
E
V
A
K
I
---
L
D
--
I
H
H
V
-----------
L
N
H
F
P
R
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
V
K
-----
D
P
S
-
L
L
L
L
D
E
P
F
S
N
L
------
D
A
R
M
R
D
S
A
R
A
L
V
K
E
V
Q
S
R
-
L
G
V
T
L
L
V
V
S
H
D
P
A
D
I
F
A
I
A
D
R
V
G
V
L
V
K
G
-
K
L
V
Q
V
G
K
P
E
D
L
Y
D
N
P
V
S
I
Q
V
A
S
LIGEIN
E
L
E
G
K
V
T
N
-----------------
E
G
V
V
I
G
S
L
RFPVSVSSDRAIIGIRPEDVKLSKDVIKDDSWILVGKGKVKVIGYQGGLFRITITPLDSEEEIFTYSDHPIHSGEEVLVYVRKDKIKVFEK
43
Fugue
70.43
23%
-104
- C1 -
1Z47
1
?
A:
[11-355]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GS
M
T
-
I
E
F
V
G
V
E
K
I
Y
--
P
----
G
---
G
A
R
S
V
R
G
V
S
F
Q
I
R
E
G
E
M
V
G
L
L
G
P
S
G
S
G
K
T
T
I
L
R
L
I
A
G
L
--------
E
R
------
P
T
K
G
D
V
W
I
G
G
K
R
V
T
---
D
L
--
P
---
P
Q
K
R
N
---
V
G
L
V
F
Q
N
Y
A
--
L
F
Q
H
M
T
V
Y
D
N
V
--------
S
F
G
L
R
-
E
-----
K
R
---
V
P
K
D
E
M
-
D
A
R
V
R
E
L
L
R
F
---
M
R
--
L
E
S
Y
-----------
A
N
R
F
P
H
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
A
P
-----
R
P
Q
-
V
L
L
F
D
E
P
F
A
A
I
------
D
T
Q
I
R
R
E
L
R
T
F
V
R
Q
V
H
D
E
-
M
G
V
T
S
V
F
V
T
H
D
Q
E
E
A
L
E
V
A
D
R
V
L
V
L
H
-
E
G
N
V
E
Q
F
G
T
P
E
E
V
Y
E
K
P
G
T
L
F
V
A
S
F
IGE
S
N
V
W
T
R
A
V
Q
N
-----------------
G
R
I
E
V
A
G
A
A
L
P
V
DPAVSEG
S
E
V
A
V
V
V
R
PKD
V
E
L
Q
P
A
S
EREAHAQVV
R
S
A
F
KGS
Y
S
A
C
W
I
R
T
KD
G
E
V
W
E
V
H
V
P
SADRHRWSPG
A
W
V
H
M
N
V
T
R
W
F
I
F
P
R--
63
HHSearch
66.95
22%
-116
- C1 -
2IHY
1
?
A:
[20-261]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
L
-
I
Q
L
D
Q
I
G
R
M
K
--
Q
----
G
---
K
T
-
I
L
K
K
I
S
W
Q
I
A
K
G
D
K
W
I
L
Y
G
L
N
G
A
G
K
T
T
L
L
N
I
L
N
A
Y
E
-------
P
A
------
T
S
-
G
T
V
N
L
F
G
K
M
P
------GY
S
---
A
E
T
V
R
Q
H
-
I
G
F
V
S
H
S
L
L
E
K
F
Q
E
G
E
R
V
I
D
V
V
I
S
G
A
----------------------
I
D
D
E
I
-
R
N
E
A
H
Q
L
L
K
L
---
V
G
--
M
S
A
K
-----------
A
Q
Q
Y
I
G
Y
L
S
T
G
E
K
Q
R
V
M
I
A
R
A
L
M
G
-----
Q
P
Q
-
V
L
I
L
D
E
P
A
A
G
L
------
D
F
I
A
R
E
S
L
L
S
I
L
D
S
L
S
D
S
Y
P
T
L
A
M
I
Y
V
T
H
F
I
E
E
I
T
A
N
F
S
K
I
L
L
L
K
D
G
Q
S
I
Q
Q
G
A
V
E
D
I
L
T
S
E
N
M
S
R
F
F
Q
K
------
N
V
A
V
Q
R
W
N
-----------------
N
R
F
S
M
A
M
L
-------------------------------------------------------------------------------------------
59
HHSearch
66.21
31%
-86
- C1 -
3ZDQ
-
ABCBA_HUMAN
A:
[341-572]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-
L
E
F
K
N
V
H
F
A
Y
--
P
----
A
RPE
V
P
-
I
F
Q
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
-------
D
P
------
A
S
-
G
T
I
S
L
D
G
H
D
I
R
---
Q
L
--
N
---
P
V
W
L
R
S
K
-
I
G
T
V
S
Q
E
P
I
---
L
F
S
C
S
I
A
E
N
I
A
Y
G
A
----
D
D
P
S
S
----------------
V
T
-
A
E
E
I
Q
R
V
A
E
V
---
A
N
--
A
V
A
F
I
R
N
FPQGFN
T
V
V
G
E
K
G
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
-----
N
P
K
-
I
L
L
L
D
E
A
T
S
A
L
------
D
A
E
N
E
Y
L
V
Q
E
A
L
D
R
L
M
---
D
G
R
T
V
L
V
I
A
H
R
L
S
T
I
-
K
N
A
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
G
K
H
E
E
L
L
S
K
P
------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
65.94
26%
-102
- C1 -
4HZI
1
?
A:
[34-277]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
-
L
S
L
E
K
I
S
Y
K
P
--
T
----
G
---
K
T
-
I
L
D
S
V
S
F
E
I
K
T
N
E
H
C
V
L
L
G
R
N
G
A
G
K
S
T
L
V
N
L
I
Y
G
M
I
WAT
S
G
T
I
R
L
------
F
Q
E
T
Y
G
E
I
A
I
Q
D
L
R
-------------
K
R
I
G
I
-
L
D
S
S
Q
--------
R
K
L
T
V
K
D
T
I
L
T
G
L
----
F
H
T
I
G
-
Y
-----
Y
R
---
D
P
S
P
E
E
-
E
T
K
T
L
Q
I
L
K
D
---
S
D
--
L
L
S
K
-----------
K
D
Q
L
Y
N
T
L
S
S
G
E
K
K
K
I
L
F
L
R
S
I
V
N
-----
E
P
D
-
F
L
I
M
D
E
P
C
S
S
L
------
D
L
T
A
R
E
D
F
L
G
F
L
K
E
Y
H
S
K
-
K
K
F
T
S
L
Y
I
T
H
R
P
E
E
I
P
D
F
Y
S
K
A
V
L
L
K
E
G
K
V
I
H
F
G
P
I
E
E
C
F
T
E
K
N
L
E
D
L
Y
D
I
------
P
L
Q
V
Q
R
I
E
-----------------
N
T
W
S
V
I
P
K
-------------------------------------------------------------------------------------------
36
Fugue
65.85
23%
-94
- C1 -
3TUZ
3
METN_ECOLI
H:
[23-362]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
M
-
I
K
L
S
N
I
T
K
V
F
--
H
QGTR
T
---
I
Q
-
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
-------
R
P
-------
T
E
G
S
V
L
V
D
G
Q
E
L
T
---
T
L
--
S
---
E
S
E
L
T
K
A
-
R
R
Q
I
G
M
I
-
F
--
Q
H
F
N
L
L
S
S
R
T
V
F
G
N
V
----
A
L
P
L
E
-
L
-----
D
N
---
T
P
K
D
E
V
-
K
R
R
V
T
E
L
L
S
L
---
V
G
--
L
G
D
K
-----------
H
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
-----
N
P
K
-
V
L
L
C
D
Q
A
T
S
A
L
------
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
-
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
H
P
K
T
P
L
A
Q
K
F
------
I
Q
S
T
L
H
L
D
IPEDYQERLQAEPFTDC
V
P
M
L
R
L
E
F
TGQSVDAPLLSETARRFNVNNNIISAQMDYAGGVKFGIMLTEMHGTQQDTQAAIAWLQEHHVKVEV-------------------------
53
HHSearch
65.24
25%
-89
- C1 -
1OXX
21
?
K:
[3-232]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
-
I
I
V
K
N
V
S
K
V
F
--
K
----
K
GK-
V
V
-
A
L
D
N
V
N
I
N
I
E
N
G
E
R
F
G
I
L
G
P
S
G
A
G
K
T
T
F
M
R
I
I
A
G
L
D
-------
V
P
------
S
T
-
G
E
L
Y
F
D
D
R
L
V
A
---
S
N
--
G
KLI
V
P
P
E
D
R
K
-
I
G
M
V
F
Q
T
W
A
--
L
Y
P
N
L
T
A
F
E
N
I
A
F
P
L
----
T
N
M
K
-------------
M
S
K
E
E
I
-
R
K
R
V
E
E
V
A
K
I
---
L
D
--
I
H
H
V
-----------
L
N
H
F
P
R
E
L
S
G
A
Q
Q
Q
R
V
A
L
A
R
A
L
V
K
-----
D
P
S
-
L
L
L
L
D
E
P
F
S
N
L
------
D
A
R
M
R
D
S
A
R
A
L
V
K
E
V
Q
S
R
-
L
G
V
T
L
L
V
V
S
H
D
P
A
D
I
F
A
I
A
D
R
V
G
V
L
V
K
G
K
L
V
Q
V
G
K
P
E
D
L
Y
D
N
P
V
S
I
Q
V
A
S
L
------
I
G
E
I
N
E
L
E
-----------------
G
K
V
T
N
E
G
V
-------------------------------------------------------------------------------------------
54
HHSearch
62.61
30%
-94
- C1 -
3D31
-
?
A:
[1-219]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
-
I
E
I
E
S
L
S
R
K
W
--
K
----
N
----
F
-
S
L
D
N
L
S
L
K
V
E
S
G
E
Y
F
V
I
L
G
P
T
G
A
G
K
T
L
F
L
E
L
I
A
G
F
H
-------
V
P
------
D
S
-
G
R
I
L
L
D
G
K
D
V
T
---
D
L
--
S
-----
P
E
K
H
D
-
I
A
F
V
Y
Q
N
Y
S
--
L
F
P
H
M
N
V
K
K
N
L
E
F
G
M
----
R
M
K
K
-------------
I
---
K
D
-
P
K
R
V
L
D
T
A
R
D
---
L
K
--
I
E
H
L
-----------
L
D
R
N
P
L
T
L
S
G
G
E
Q
Q
R
V
A
L
A
R
A
L
V
T
-----
N
P
K
-
I
L
L
L
D
E
P
L
S
A
L
------
D
P
R
T
Q
E
N
A
R
E
M
L
S
V
L
H
K
K
-
N
K
L
T
V
L
H
I
T
H
D
Q
T
E
A
R
I
M
A
D
R
I
A
V
V
M
D
G
K
L
I
Q
V
G
K
P
E
E
I
F
E
K
P
V
E
G
R
V
A
S
F
------
V
G
F
E
N
V
L
K
-----------------
G
R
V
I
S
A
E
Q
-------------------------------------------------------------------------------------------
45
HHSearch
62.61
24%
-100
- C1 -
1Z47
1
?
A:
[13-237]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
T
-
I
E
F
V
G
V
E
K
I
Y
--
P
G---
G
---
A
R
-
S
V
R
G
V
S
F
Q
I
R
E
G
E
M
V
G
L
L
G
P
S
G
S
G
K
T
T
I
L
R
L
I
A
G
L
E
-------
R
P
------
T
K
-
G
D
V
W
I
G
G
K
R
V
T
---
D
L
--
P
-----
P
Q
K
R
N
-
V
G
L
V
F
Q
N
Y
A
--
L
F
Q
H
M
T
V
Y
D
N
V
S
F
G
L
----
R
E
K
R
-------------
V
P
K
D
E
M
-
D
A
R
V
R
E
L
L
R
F
---
M
R
--
L
E
S
Y
-----------
A
N
R
F
P
H
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
A
P
-----
R
P
Q
-
V
L
L
F
D
E
P
F
A
A
I
------
D
T
Q
I
R
R
E
L
R
T
F
V
R
Q
V
H
D
E
-
M
G
V
T
S
V
F
V
T
H
D
Q
E
E
A
L
E
V
A
D
R
V
L
V
L
H
E
G
N
V
E
Q
F
G
T
P
E
E
V
Y
E
K
P
G
T
L
F
V
A
S
F
------
I
G
E
S
N
V
W
T
-----------------
R
A
V
Q
N
G
R
I
-------------------------------------------------------------------------------------------
40
Fugue
62.26
22%
-85
- C1 -
3B60
2
MSBA_SALTY
A:
[10-581]
W
Q
T
F
R
R
L
W
P
T
I
A
PFK
A
G
L
I
V
A
G
I
A
L
I
L
N
A
A
S
D
T
F
M
L
S
L
LKPLLDDGFGKTDRSVLLW
M
P
L
V
V
I
G
L
M
I
L
R
G
I
T
S
Y
I
S
S
Y
C
I
S
W
V
S
G
K
V
V
M
T
M
R
R
R
L
F
G
H
M
M
G
MPVAFFDKQS
T
G
T
L
L
S
R
I
T
Y
D
S
E
Q
V
A
S
S
S
S
G
A
L
I
T
V
V
R
E
G
A
S
I
I
G
L
F
I
M
M
FYYS
W
Q
L
S
I
I
L
V
V
L
A
P
I
V
S
I
A
I
R
V
V
S
K
R
F
R
S
I
S
K
N
M
Q
N
T
M
G
Q
V
T
T
S
A
E
Q
M
L
K
G
H
KEVLIFGG
Q
E
V
E
T
K
R
F
D
K
V
S
N
K
M
R
L
Q
G
M
K
M
V
S
A
S
S
I
S
D
P
I
I
Q
L
I
A
S
L
A
L
A
F
V
L
Y
A
A
S
FPSVMDSLT
A
G
T
I
T
V
V
F
S
S
M
I
A
L
M
R
P
L
K
S
L
T
N
V
N
A
Q
F
Q
R
G
M
A
A
C
Q
T
L
F
A
I
L
D
SEQEK
D
E
G
K
RVIDRAT
G
D
-
L
E
F
R
N
V
T
F
T
Y
PG
R
----
E
---
V
P
-
A
L
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
-------
D
I
-------
D
E
G
H
I
L
M
D
G
H
D
L
R
---
E
Y
--
T
---
L
A
S
L
R
N
Q
-
V
A
L
V
S
Q
-
N
V
--
H
L
F
N
D
T
V
A
N
N
I
A
Y
A
R
----
T
E
E
Y
S
-
R
-----
E
Q
---
I
E
E
A
A
R
-
M
A
Y
A
M
D
F
I
N
K
---
M
D
NG
L
D
T
I
-----------
I
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
-----
D
S
P
-
I
L
I
L
D
E
A
T
S
A
L
------
D
T
E
S
E
R
A
I
Q
A
A
L
D
E
L
Q
K
N
-
R
--
T
S
L
V
I
A
H
R
L
S
T
I
E
Q
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
L
A
Q
H
G
V
Y
A
Q
L
H
K
M
------
Q
F
G
-------------------------------------------------------------------------------------------------------------------------
50
HHSearch
61.92
25%
-105
- C1 -
2YYZ
3
?
A:
[3-224]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
-
I
R
V
V
N
L
K
K
Y
F
--
G
----
K
---
V
K
-
A
V
D
G
V
S
F
E
V
K
D
G
E
F
V
A
L
L
G
P
S
G
C
G
K
T
T
T
L
L
M
L
A
G
I
Y
-------
K
P
------
T
S
-
G
E
I
Y
F
D
D
V
L
V
N
---
D
I
--
P
---
P
--
K
Y
R
E
-
V
G
M
V
F
Q
N
Y
A
--
L
Y
P
H
M
T
V
F
E
N
I
A
F
P
L
----
R
A
R
R
-------------
I
S
K
D
E
V
-
E
K
R
V
V
E
I
A
R
K
---
L
L
--
I
D
N
L
-----------
L
D
R
K
P
T
Q
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
V
K
-----
Q
P
K
-
V
L
L
F
D
E
P
L
S
N
L
------
D
A
N
L
R
M
I
M
R
A
E
I
K
H
L
Q
Q
E
-
L
G
I
T
S
V
Y
V
T
H
D
Q
A
E
A
M
T
M
A
S
R
I
A
V
F
N
Q
G
K
L
V
Q
Y
G
T
P
D
E
V
Y
D
S
P
K
N
M
F
V
A
S
F
------
I
G
N
P
P
T
N
F
-----------------
L
R
D
F
S
V
S
V
-------------------------------------------------------------------------------------------