@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_0833: (2015-12-18 )
MKKHILSLTLGSLLVSTLSAEDDGFYTSVGYQIGEAAQMVTNTKGIQDLSDRYESLNNLLNRYSTLNTLIKLSADPSAINAVRENLGASAKNLIGDKANSPAYQAVLLAINAAVGFWNVVGYVTQCGGNANGQKSISSKTIFNNEPGYRSTSITCSLNGHSPGYYGPMSIENFKKLNEAYQILQTALKRGLPALKENNGKVNVTYTYTCSGDGNNNCSSQVTGVNNQKDGTKTKIQTIDGKSVTTTISSKVVDSRADGNTTGVSYTEITNKLEGVPDSAQALLAQASTLINTINNACPYFHASNSSEANAPKFSTTTGKICGAFSEEISAIQKMITDAQELVNQTSVINEHEQTTPVGNNNGKPFNPFTDASFAQGMLANASAQAKMLNLAEQVGQAINPERLSGTFQNFVKGFLATCNNPSTAGTGGTQGSAPGTVTTQTFASGCAYVGQTITNLKNSIAHFGTQEQQIQQAENIADTLVNFKSRYSELGNTYNSITTALSNIPNAQSLQNAVSKKNNPYSPQGIDTNYYLNQNSYNQIQTINQELGRNPFRKVGIVSSQTNNGAMNGIGIQVGYKQFFGQKRKWGARYYGFFDYNHAFIKSSFFNSASDVWTYGFGADALYNFINDKATNFLGKNNKLSVGLFGGIALAGTSWLNSEYVNLATMNNVYNAKMNVANFQFLFNMGVRMNLARPKKKDSDHAAQHGIELGLKIPTINTNYYSFMGAELKYRRLYSVYLNYVFAY
Atome Classification :
(20 SA)
-----------------------------------------.........-10........20..---......30-----........40.....-----...50........60........70......-..-80....----....90........100.......110.......---------120........130......--------------.140.......150---........160.......170--.........180.......190.......200.......210.......220.......230.......240.......250.--......260.......270.......280.......290.......300.......310.......320.......330.......340........350.......360...----....370........380....--------...--390.......400.......410.......420.......430.-----......440.......450---.......460.......470.-........480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600...-....610.......620.......630.......640--.......650.......660.......670---------.......680.......--690.-......700..-.------------....710.......720..-.----.----....730.......740..-------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-----------------------------------------MK
K
H
I
L
S
L
T
-
L
G
S
L
L
V
S
T
LSAEDD---G
F
Y
T
S
V
GY-----QI
G
E
A
A
Q
M
V
TNTKG
I
-----
Q
D
L
S
D
R
Y
E
S
L
N
N
L
L
N
R
Y
S
T
L
N
T
L
IKLSAD
P
S
-
A
I
-
N
A
V
R
E
N
----LG
A
S
A
K
N
LIGDKANS
P
A
Y
Q
A
V
L
L
A
I
N
A
A
V
G
F
W
N
V
---------
V
G
-
Y
V
T
QCGGNANGQKSISS--------------KTIFNNEPGYR
S
T
----
S
I
T
C
S
LNGHSPGYYGPM
S
I
----
E
N
F
K
K
L
N
E
A
Y
Q
I
L
Q
T
A
L
K
RGL
P
A
L
KENNG
K
V
N
V
T
Y
T
Y
T
CSGDGNNNCSSQVTGVNNQKDGT
K
T
K
I
Q
T
IDGK
S
V
T
T
T
I
S
S
K
V
VD--SRADGNTTGV
S
Y
T
E
I
T
N
K
LEGVP
D
S
A
Q
A
L
L
A
Q
A
S
T
L
I
N
T
I
NNACP
Y
F
HASNSSEANAPKFSTTT
G
K
I
C
G
A
F
S
E
E
I
S
A
I
Q
K
M
I
T
D
A
Q
E
L
-
V
N
Q
T
S
VINEHEQTTPVGNNNGKPF----NPFT
D
A
-
S
F
A
Q
G
M
LANA
S
A
Q
A
K
--------
M
L
N
--
L
A
E
Q
V
G
QAI
N
P
E
R
L
S
G
T
F
Q
N
F
V
K
G
F
L
A
TCNNPSTAGTGGTQGSA-----PG
T
V
T
T
Q
T
F
A
S
G
C
A
Y
V
G
Q
T
---
I
T
N
L
K
N
S
I
A
HFG
T
Q
E
Q
Q
I
--
Q
-
Q
A
E
N
I
A
D
T
L
V
N
F
K
S
R
Y
S
E
LG
N
T
Y
N
S
I
T
T
A
L
SNIP
N
A
Q
S
L
Q
N
A
V
SKKNNPYSPQGIDT
N
Y
Y
LNQNSY
N
Q
I
Q
T
I
N
Q
E
LGRNPFRKVG
I
V
SSQTNNGAM
N
G
I
G
I
Q
V
G
Y
K
Q
FFGQKRKWGA
R
Y
Y
G
F
FDY
N
H
A
F
I
K
S
S
F-FNSASD
V
W
TYGF
G
A
D
A
L
Y
N
F
I
N
D
K
A
T
N
FLGKNN
K
L
S
V
--
G
L
FG
G
I
A
L
AGTSWLNSE
Y
V
N
L
A
T
MNNVYNA---------KMNVA
N
F
Q
F
L
FNMG
V
R
M
--NLAR-PKKKDS
D
H
A
A
Q-H------------G
I
E
L
G
L
K
IPTINT
N
Y
Y
-
S
F-M----G----A
E
L
K
Y
R
R
L
Y
S
V
Y
L
N
Y
V
FAY-------------------------------------
1
PsiBlast_PDB
99.61
99%
-74
- C4 -
4ZH7
4
?
A:
[18-519]
-----------------------------------------------------------------------------------------------------
Q
D
L
S
D
R
Y
E
S
L
N
N
L
L
N
R
Y
S
T
L
N
T
L
I
K
L
S
A
D
P
S
-
A
I
-
N
A
V
R
E
N
----
L
G
A
S
A
K
N
L
I
G
D
K
A
N
S
P
A
Y
Q
A
V
L
L
A
I
N
A
A
V
G
F
W
N
V
---------
V
G
-
Y
V
T
Q
C
G
G
N
A
N
G
Q
K
S
I
S
S
--------------
K
T
I
F
N
N
E
P
G
Y
R
S
T
----
S
I
T
C
S
L
N
G
H
S
P
G
Y
Y
G
P
M
S
I
----
E
N
F
K
K
L
N
E
A
Y
Q
I
L
Q
T
A
L
K
R
G
L
P
A
L
K
E
N
N
G
K
V
N
V
T
Y
T
Y
T
C
S
G
D
G
N
N
N
C
S
S
Q
V
T
G
V
N
N
Q
K
D
G
T
K
T
K
I
Q
T
I
D
G
K
S
V
T
T
T
I
S
S
K
V
V
D
--
S
R
A
D
G
N
T
T
G
V
S
Y
T
E
I
T
N
K
L
E
G
V
P
D
S
A
Q
A
L
L
A
Q
A
S
T
L
I
N
T
I
N
N
A
C
P
Y
F
H
A
----------
F
S
T
T
T
G
K
I
C
G
A
F
S
E
E
I
S
A
I
Q
K
M
I
T
D
A
Q
E
L
-
V
N
Q
T
S
V
I
N
E
H
E
Q
T
T
P
V
G
N
N
N
G
K
P
F
----
N
P
F
T
D
A
-
S
F
A
Q
G
M
L
A
N
A
S
A
Q
A
K
--------
M
L
N
--
L
A
E
Q
V
G
Q
A
I
N
P
E
R
L
S
G
T
F
Q
N
F
V
K
G
F
L
A
T
C
N
N
P
S
-------
Q
G
S
A
-----
P
G
T
V
T
T
Q
T
F
A
S
G
C
A
Y
V
G
Q
T
---
I
T
N
L
K
N
S
I
A
H
F
G
T
Q
E
Q
Q
I
--
Q
-
Q
A
E
N
I
A
D
T
L
V
N
F
K
S
R
Y
S
E
L
G
N
T
Y
N
S
I
T
T
A
L
S
N
I
P
N
A
Q
S
L
Q
N
A
V
S
K
K
N
N
P
Y
S
P
Q
G
I
D
T
N
Y
Y
L
N
Q
N
S
Y
N
Q
I
Q
T
I
N
Q
E
L
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
Fugue
82.56
100%
3
- C4 -
4ZH0
-
?
A:
[18-518]
-----------------------------------------------------------------------------------------------------
Q
D
L
S
D
R
Y
E
S
L
N
N
L
L
N
R
Y
S
T
L
N
T
L
I
K
L
S
A
D
P
S
-
A
I
-
N
A
V
R
E
N
----
L
G
A
S
A
K
N
L
I
G
D
K
A
N
S
P
A
Y
Q
A
V
L
L
A
I
N
A
A
V
G
F
W
N
V
---------
V
G
-
Y
V
T
Q
C
G
G
N
A
N
G
Q
K
S
I
S
S
--------------
K
T
I
F
N
N
E
P
G
Y
R
S
T
----
S
I
T
C
S
L
N
G
H
S
P
G
Y
Y
G
P
M
S
I
----
E
N
F
K
K
L
N
E
A
Y
Q
I
L
Q
T
A
L
K
R
G
L
P
A
L
K
E
N
N
G
K
V
N
V
T
Y
T
Y
T
C
S
G
D
G
N
N
N
C
S
S
Q
V
T
G
V
N
N
Q
K
D
G
T
K
T
K
I
Q
T
I
D
G
K
S
V
T
T
T
I
S
S
K
V
V
D
--
S
R
A
D
G
N
T
T
G
V
S
Y
T
E
I
T
N
K
L
E
G
V
P
D
S
A
Q
A
L
L
A
Q
A
S
T
L
I
N
T
I
N
N
A
C
P
Y
F
H
A
--------
P
K
F
S
T
T
T
G
K
I
C
G
A
F
S
E
E
I
S
A
I
Q
K
M
I
T
D
A
Q
E
L
-
V
N
Q
T
S
V
I
N
E
H
E
Q
T
T
P
V
G
N
N
N
G
K
P
F
----
N
P
F
T
D
A
-
S
F
A
Q
G
M
L
A
N
A
S
A
Q
A
K
--------
M
L
N
--
L
A
E
Q
V
G
Q
A
I
N
P
E
R
L
S
G
T
F
Q
N
F
V
K
G
F
L
A
T
C
N
N
P
S
-------
Q
G
S
A
-----
P
G
T
V
T
T
Q
T
F
A
S
G
C
A
Y
V
G
Q
T
---
I
T
N
L
K
N
S
I
A
H
F
G
T
Q
E
Q
Q
I
--
Q
-
Q
A
E
N
I
A
D
T
L
V
N
F
K
S
R
Y
S
E
L
G
N
T
Y
N
S
I
T
T
A
L
S
N
I
P
N
A
Q
S
L
Q
N
A
V
S
K
K
N
N
P
Y
S
P
Q
G
I
D
T
N
Y
Y
L
N
Q
N
S
Y
N
Q
I
Q
T
I
N
Q
E
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
82.16
98%
3
- C4 -
4ZH0
-
?
A:
[18-518]
-----------------------------------------------------------------------------------------------------
Q
D
L
S
D
R
Y
E
S
L
N
N
L
L
N
R
Y
S
T
L
N
T
L
I
K
L
S
A
D
P
S
-
A
I
-
N
A
V
R
E
N
----
L
G
A
S
A
K
N
L
I
G
D
K
A
N
S
P
A
Y
Q
A
V
L
L
A
I
N
A
A
V
G
F
W
N
V
---------
V
G
-
Y
V
T
Q
C
G
G
N
A
N
G
Q
K
S
I
S
S
--------------
K
T
I
F
N
N
E
P
G
Y
R
S
T
----
S
I
T
C
S
L
N
G
H
S
P
G
Y
Y
G
P
M
S
I
----
E
N
F
K
K
L
N
E
A
Y
Q
I
L
Q
T
A
L
K
R
G
L
P
A
L
K
E
N
N
G
K
V
N
V
T
Y
T
Y
T
C
S
G
D
G
N
N
N
C
S
S
Q
V
T
G
V
N
N
Q
K
D
G
T
K
T
K
I
Q
T
I
D
G
K
S
V
T
T
T
I
S
S
K
V
V
D
--
S
R
A
D
G
N
T
T
G
V
S
Y
T
E
I
T
N
K
L
E
G
V
P
D
S
A
Q
A
L
L
A
Q
A
S
T
L
I
N
T
I
N
N
A
C
P
Y
F
H
A
--------
P
K
F
S
T
T
T
G
K
I
C
G
A
F
S
E
E
I
S
A
I
Q
K
M
I
T
D
A
Q
E
L
-
V
N
Q
T
S
V
I
N
E
H
E
Q
T
T
P
V
G
N
N
N
G
K
P
F
----
N
P
F
T
D
A
-
S
F
A
Q
G
M
L
A
N
A
S
A
Q
A
K
--------
M
L
N
--
L
A
E
Q
V
G
Q
A
I
N
P
E
R
L
S
G
T
F
Q
N
F
V
K
G
F
L
A
T
C
N
N
P
S
-------
Q
G
S
A
-----
P
G
T
V
T
T
Q
T
F
A
S
G
C
A
Y
V
G
Q
T
---
I
T
N
L
K
N
S
I
A
H
F
G
T
Q
E
Q
Q
I
--
Q
-
Q
A
E
N
I
A
D
T
L
V
N
F
K
S
R
Y
S
E
L
G
N
T
Y
N
S
I
T
T
A
L
S
N
I
P
N
A
Q
S
L
Q
N
A
V
S
K
K
N
N
P
Y
S
P
Q
G
I
D
T
N
Y
Y
L
N
Q
N
S
Y
N
Q
I
Q
T
I
N
Q
E
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
Fugue
55.88
17%
-21
- C4 -
4XVK
4
DPOLN_HUMAN
A:
[1-666]
------------------------------------------
K
K
H
F
C
D
I
R
H
L
D
D
W
A
K
S
Q
L
I
E
M
L
K
Q
AA
A
L
V
I
T
V
M
Y
TDGST
Q
L
G
A
D
Q
T
P
V
S
S
V
R
G
I
-----
V
V
L
V
K
R
-
Q
A
C
G
P
V
L
E
G
F
V
S
D
D
P
C
I
Y
I
Q
I
E
H
S
-
A
I
W
D
Q
E
Q
E
A
----
H
Q
Q
F
A
R
N
V
L
F
Q
T
M
K
---
C
K
C
P
V
I
C
F
N
A
K
D
F
V
R
I
V
---------
L
Q
-
F
F
----
G
N
D
G
S
W
K
H
V
A
D
--------------
F
I
G
L
D
----
P
R
I
A
----
A
W
L
I
D
P
S
D
A
T
P
-------------
S
F
E
D
L
V
E
K
Y
C
--------------
E
K
S
I
T
V
K
V
N
S
T
Y
-----
G
N
-------
S
S
R
N
I
V
N
Q
N
V
R
E
N
L
K
T
L
--
Y
R
L
T
M
D
L
C
S
K
L
K
D
--
Y
---------
G
L
W
Q
L
F
R
T
L
E
-
L
P
--
L
I
P
I
L
A
V
M
E
S
H
A
I
Q
V
N
------------------------------
K
E
E
M
E
K
T
S
A
L
L
G
A
R
L
K
E
-
L
E
Q
E
A
H
F
V
A
G
E
R
F
L
I
T
S
N
N
Q
L
R
E
I
L
FGK
L
K
L
H
L
L
-
S
Y
P
S
T
S
E
A
V
L
N
A
L
R
D
--------
L
H
P
--
L
P
K
I
I
L
E
Y
R
Q
V
H
K
I
K
S
T
F
---
V
D
G
L
L
A
C
M
K
K
G
S
I
S
S
T
W
N
Q
T
G
T
V
-----
T
G
R
L
S
A
K
---------
H
P
N
---
I
Q
G
I
S
K
H
P
I
Q
I
T
T
P
K
K
I
L
--
T
I
S
P
R
A
M
F
V
S
S
K
G
H
T
F
L
A
A
D
F
S
Q
I
E
L
R
I
L
T
H
L
S
G
D
P
E
L
L
K
L
D
D
V
F
S
T
L
T
S
Q
W
K
D
V
P
V
E
-----------
Q
V
T
H
A
D
R
E
Q
T
K
K
V
V
Y
A
V
V
Y
G
A
G
K
E
R
L
A
A
C
L
G
V
P
I
Q
E
A
A
Q
F
L
E
S
F
L
Q
K
----
Y
K
K
I
K
D
F
A
R
A
A
I
A
Q
C
H
-
Q
T
G
C
V
V
-
S
I
M
G
R
R
R
P
L
P
R
I
H
A
H
D
Q
Q
L
R
A
Q
A
E
R
Q
A
V
N
F
--
V
V
Q
G
S
A
A
D
L
C
K
L
A
M
I
H
V
F
T
A
V
A
A
S
H
T
L
T
A
R
---------
L
V
A
Q
I
H
D
E
L
L
F
E
V
E
D
P
Q
I
P
E
C
A
A
-
L
V
R
R
T
M
E
S
L
E
Q
V
Q
------------
A
L
E
L
Q
L
Q
V
P
-----------
L
----
K
----
V
S
L
S
A
G
R
S
W
G
H
L
V
P
L
Q
----------------------------------------
17
Fugue
54.21
17%
-17
- C2 -
2BVL
8
TOXB_PEPDI
A:
[1-543]
-------------------------------------------
M
S
L
V
N
R
K
-
Q
L
E
K
M
A
N
V
R
F
R
T
Q
E
---
D
E
Y
V
A
I
L
D
-----
A
L
E
E
Y
H
N
M
S
E
N
T
----------
V
V
E
K
Y
L
K
L
K
D
I
N
S
L
T
D
I
C
I
D
T
Y
K
K
S
G
R
N
K
-
A
L
-
K
K
F
K
E
Y
----
L
V
T
E
V
L
E
L
K
N
N
N
L
T
P
V
E
K
N
L
H
F
V
W
I
--------------------------
G
G
Q
I
N
--------------------------------------------------
D
T
A
I
N
Y
I
----
N
Q
W
K
D
V
N
S
D
Y
-------------------
N
V
N
V
F
Y
-----------------------
D
S
N
A
F
L
I
N
T
L
K
K
T
V
V
E
S
A
I
N
D
T
L
E
S
--
F
R
E
N
L
N
D
P
R
-------------
F
D
Y
N
K
F
F
R
K
R
M
E
I
I
Y
D
K
Q
K
N
F
I
N
Y
Y
K
A
Q
R
E
E
N
P
E
L
I
I
D
D
I
V
K
T
Y
L
S
N
E
Y
S
K
E
I
D
E
L
N
T
Y
I
E
E
S
L
N
K
-
I
T
Q
N
S
G
N
D
V
R
N
F
---
G
E
F
K
N
G
E
S
F
----
N
L
Y
E
Q
E
-
L
V
E
R
W
N
L
A
A
A
S
D
I
L
R
--------
I
S
A
--
L
K
E
I
G
G
M
Y
L
D
V
D
M
L
P
G
I
----
Q
P
D
L
F
E
S
I
E
K
P
S
S
-------------------
V
T
V
D
F
W
E
M
T
K
L
--
E
A
---
I
M
K
Y
K
E
Y
I
P
E
Y
T
S
E
H
F
D
M
LD
E
-
E
V
Q
S
S
F
E
S
V
L
A
S
K
S
D
K
S
E
I
F
S
S
L
G
D
M
E
A
S
--------
P
L
E
V
K
I
A
F
N
S
K
G
I
I
N
Q
G
L
I
S
V
----
K
D
S
Y
C
S
N
L
I
V
K
Q
I
E
N
R
Y
K
I
L
N
N
S
L
N
P
A
I
S
E
D
N
--------------------------
D
F
N
T
T
T
N
T
F
I
D
S
I
M
-
A
E
A
N
A
D
---------------
N
G
R
F
M
M
E
L
G
K
Y
--
L
R
V
--
G
F
F
---------------
P
D
V
K
T
T
I
N
L
S
G
P
---------
E
A
Y
A
A
A
Y
Q
D
L
L
M
F
K
E
G
S
--
M
N
I
H
-
L
I
E
A
D
L
R
N
F
E
I
-
S
------------
K
T
N
I
S
Q
S
T
E
Q
E
M
A
S
L
W
-
S
F
-
D
----
D
----
A
R
A
K
A
Q
F
E
E
Y
K
R
N
Y
F
E
G
A
L
-------------------------------------
15
Fugue
52.30
20%
-24
* C4 *
4O5J
3
?
A:
[27-400]
-----------------------------------------------------------------------------------------------
L
-----
K
N
L
N
E
K
Y
E
Q
L
S
Q
Y
L
N
Q
V
A
S
L
K
Q
S
I
Q
N
A
N
N
I
E
-
L
V
-
N
S
S
L
N
Y
----
L
K
S
F
T
N
N
N
Y
N
S
T
T
Q
S
P
I
F
N
A
V
Q
A
V
I
T
S
V
L
G
F
W
S
L
Y
AGNYFTFF
V
G
-
K
K
V
D
S
G
Q
P
A
S
V
Q
G
N
P
P
F
--------------
K
T
I
I
E
N
C
S
G
I
E
N
--------
C
A
M
D
--------
Q
T
T
Y
----
D
K
M
K
K
L
A
E
D
L
Q
A
A
Q
T
---------
N
S
A
T
K
G
N
N
L
C
A
L
S
G
C
A
A
T
S
N
P
P
N
S
T
----
V
S
N
A
L
N
L
A
Q
Q
L
M
D
L
I
A
N
T
K
T
A
M
M
W
K
N
I
V
I
S
GV
S
N
T
S
G
A
I
T
S
T
N
Y
P
T
Q
Y
A
V
F
N
N
I
-
K
A
M
I
P
I
L
Q
Q
A
V
T
L
S
Q
S
N
H
T
L
S
A
S
L
Q
A
Q
A
T
G
S
Q
T
N
P
K
F
A
K
D
I
Y
T
F
A
Q
N
Q
K
Q
V
I
S
Y
A
Q
D
I
F
N
L
F
N
S
I
P
A
E
Q
Y
K
Y
L
E
K
A
Y
L
K
I
P
--
N
A
G
S
T
P
T
----
N
P
Y
R
Q
V
-
V
N
L
N
Q
E
V
Q
T
I
K
N
N
V
S
Y
Y
G
N
R
V
D
A
A
L
S
--
V
A
R
D
V
Y
N
L
K
S
N
Q
A
E
I
V
T
A
Y
N
D
A
K
T
L
S
E
E
I
S
K
L
P
H
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
Fugue
49.20
14%
-27
- C1 -
4ZUZ
-
?
A:
[7-863]
D
V
I
K
F
K
EPERCDY
L
Y
V
D
ENN
K
V
H
I
L
L
P
IVGGDE
I
G
L
D
N
TC
Q
T
A
V
E
L
I
T
F
F
-
Y
G
S
A
H
S
G
V
T
K
Y
S
A
E
---
H
Q
L
S
E
Y
K
R
-----
Q
L
E
E
D
I
K
A
I
N
S
Q
K
K
I
SPHAY
D
D
L
L
K
E
K
I
E
R
L
Q
Q
I
E
K
Y
I
E
L
I
Q
V
L
K
K
Q
Y
D
E
Q
N
D
I
-
R
Q
L
R
T
G
GIPQ
L
P
S
G
V
K
E
I
I
K
---
S
S
E
N
A
F
A
V
R
L
S
P
Y
D
N
D
K
F
T
R
F
---------
D
D
-
P
L
F
N
V
K
R
N
I
S
K
Y
D
T
P
S
R
Q
A
P
I
P
I
YEG
L
G
Y
R
L
R
S
T
L
F
P
E
D
K
T
P
T
P
I
N
K
K
S
L
R
D
K
V
K
S
T
V
L
S
H
Y
K
D
E
D
R
IDGE
K
K
D
E
K
L
N
E
L
I
T
N
L
Q
N
E
L
V
K
E
L
V
K
S
D
P
Q
Y
S
K
L
S
L
S
K
D
P
R
G
K
E
I
N
Y
D
Y
L
V
N
S
L
M
L
V
D
N
D
S
E
-
I
G
D
W
I
D
T
I
L
D
A
T
V
D
S
T
V
W
A
V
Q
A
S
--
S
P
F
Y
Q
G
A
K
E
I
S
S
---
D
R
D
A
D
K
I
S
I
R
V
Q
Y
L
L
A
E
A
N
I
Y
C
K
T
N
K
L
S
D
A
N
F
G
E
F
F
D
K
E
P
H
A
T
E
I
A
K
R
V
K
E
G
F
T
Q
G
A
D
I
E
P
I
I
Y
D
Y
I
N
S
N
H
A
E
-
L
G
L
K
S
P
L
T
-
G
K
Q
Q
Q
E
I
T
D
K
F
T
K
H
Y
----
N
T
I
K
E
S
P
H
F
D
E
F
F
V
A
D
P
D
K
K
G
N
--------
I
F
S
--
H
Q
G
---------
R
I
S
C
H
---
F
L
D
F
F
T
R
Q
T
K
G
K
H
P
L
G
D
L
A
S
H
Q
E
A
-----
L
Q
E
G
T
S
N
R
L
H
H
K
N
E
V
V
A
Q
G
Y
E
K
L
D
Q
F
K
K
E
V
V
K
L
L
A
E
N
K
P
K
--
E
-
L
L
D
Y
L
V
A
T
S
P
T
G
V
P
N
Y
S
M
L
S
---
K
E
T
Q
N
Y
I
A
Y
N
R
N
W
P
A
I
Q
K
E
L
E
K
A
T
S
I
P
E
S
Q
K
Q
D
L
S
R
L
L
S
R
D
N
L
Q
H
-
D
N
L
S
A
I
T
W
S
K
Y
S
S
K
P
L
L
D
V
E
L
N
K
I
A
E
G
L
E
L
T
A
K
I
-
Y
N
E
K
R
G
R
E
W
W
F
A
G
S
R
N
E
A
R
K
T
Q
C
E
E
L
Q
R
V
S
-
K
E
I
N
T
L
L
Q
S
E
S
L
T
K
S
Q
V
L
E
K
V
L
N
S
I
E
T
L
D
K
I
D
R
D
I
S
A
E
S
N
W
F
Q
S
T
L
Q
K
E
V
R
L
F
R
D
Q
L
K
D
I
C
Q
L
D
K
Y
Y
F
K
S
TKLD
E
I
I
S
L
E
M
E
E
Q
F
Q
K
I
Q
D
P
A
V
Q
Q
--
I
V
R
D
L
P
S
H
C
H
N
D
E
A
I
E
-
F
F
K
T
L
N
P
E
E
A
A
K
V
A
S
Y
L
S
L
E
Y
R
E
I
N
K
S
T
D
-
K
K
-
T
----
L
----
L
E
Q
D
I
P
R
L
F
K
E
V
N
T
Q
L
L
S
K
L
K
E
E
KAID
E
Q
V
H
E
K
L
S
Q
L
ADKIAPEHFT
R
N
N
I
I
K
W
S
T
18
Fugue
39.91
13%
-4
- C4 -
256B
3
C562_ECOLX
A:
[1-106]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
L
E
D
N
--------
M
E
T
--
L
N
D
N
L
K
V
I
E
K
A
D
N
-
A
A
Q
V
K
D
A
L
T
K
M
R
A
A
A
L
D
A
Q
K
A
T
P
P
K
L
E
D
K
S
-----
P
D
S
P
E
M
K
D
F
R
H
G
F
D
I
L
V
G
Q
---
I
D
D
A
L
K
L
A
N
E
-
G
K
V
K
E
A
Q
--
A
-
A
A
E
Q
L
K
T
T
R
N
A
Y
H
Q
K
Y
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
Fugue
38.66
16%
-18
- C4 -
1YAR
-
?
O:
[10-237]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
R
A
A
L
I
Q
N
L
R
D
S
----
Y
T
E
T
S
S
F
A
V
I
E
E
W
A
A
-------
G
T
L
Q
E
I
E
G
I
A
K
A
A
A
E
A
H
G
V
-
I
R
N
S
T
Y
G
R
A
Q
A
E
K
S
P
--------
E
----
Q
L
L
G
V
L
-
Q
R
Y
Q
D
L
C
H
N
V
Y
C
Q
A
E
--------
T
I
R
TV
I
A
I
R
I
P
E
H
K
E
E
D
N
L
G
V
A
V
Q
H
A
V
L
K
I
I
D
E
L
E
I
K
-
T
L
G
S
G
E
K
S
G
S
G
GAPTP
I
G
M
Y
A
L
R
E
Y
L
S
A
R
S
T
V
E
D
K
---
L
L
G
G
G
S
Q
-----
S
P
S
L
L
L
--
E
-
L
R
Q
I
D
A
D
F
M
L
K
V
E
L
A
T
T
H
L
S
T
M
V
R
A
V
I
N
A
Y
--
L
L
N
W
K
K
L
I
Q
P
R
T
G
S
D
H
M
V
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
37.82
31%
-17
- C4 -
4O5J
2
?
A:
[27-164]
-----------------------------------------------------------------------------------------------
L
-----
K
N
L
N
E
K
Y
E
Q
L
S
Q
Y
L
N
Q
V
A
S
L
K
Q
S
I
Q
N
A
N
N
I
E
-
L
V
-
N
S
S
L
N
Y
----
L
K
S
F
T
N
N
N
Y
N
S
T
T
Q
S
P
I
F
N
A
V
Q
A
V
I
T
S
V
L
G
F
W
S
L
Y
AGNYFTFF
V
G
K
K
V
-
D
S
G
Q
P
A
S
V
Q
G
N
P
P
F
--------------
K
T
I
I
E
N
C
S
G
I
E
N
--------
C
A
M
D
Q
--------
T
T
Y
----
D
K
M
K
K
L
A
E
D
L
Q
A
A
Q
T
N
S
A
T
K
G
N
N
L
C
A
L
S
G
C
A
A
T
S
N
P
P
N
S
T
V
S
N
A
L
N
L
A
Q
Q
L
M
D
L
I
A
N
T
K
T
A
M
M
W
K
N
I
V
I
S
G
V
S
N
T
S
G
A
I
T
S
T
N
--
Y
P
T
Q
Y
A
V
F
N
N
I
K
A
M
I
P
I
L
Q
Q
A
V
T
L
S
Q
S
N
H
T
L
S
A
S
L
Q
A
Q
A
T
G
S
Q
T
N
P
K
F
A
K
D
I
Y
T
F
A
Q
N
Q
K
Q
V
I
S
Y
A
Q
D
I
F
N
L
F
N
S
I
P
A
E
Q
Y
K
Y
L
E
K
A
Y
-
L
K
I
P
N
A
G
S
T
P
T
N
P
Y
R
Q
V
V
N
L
N
Q
E
V
----
Q
T
I
K
N
N
-
V
S
Y
Y
G
N
R
V
D
A
A
L
S
V
A
--------
R
D
V
--
Y
N
L
K
S
N
Q
A
E
I
V
T
A
Y
N
D
A
K
T
L
S
E
E
I
S
K
L
P
H
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
HHSearch
32.22
15%
4
- C3 -
1P4T
7
?
A:
[24-155]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
G
F
S
P
R
I
S
A
G
Y
R
--
I
N
--
D
-
L
R
F
A
----
V
D
Y
T
R
Y
K
N
Y
K
A
----
P
S
T
D
F
K
L
Y
S
I
G
A
S
A
I
Y
D
F
D
T
Q
S
-----------
P
V
--
K
P
Y
L
G
A
R
L
S
L
N
R
A
S
V
D
L
G
G
S
---------
D
---------
S
F
S
Q
T
S
I
G
L
G
V
L
T
G
V
S
Y
--
A
V
T
-----------
P
N
-
V
------------
D
L
D
A
G
Y
R
Y
N
Y
I
G
K
V
N
---
T
------------
V
K
-
N
V
R
S
G
E
L
S
A
G
V
R
V
K
F
-------------------------------------
6
HHSearch
30.79
9%
-24
- C3 -
2F1V
1
OMPW_ECOLI
A:
[36-191]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
T
Q
L
G
L
T
F
T
Y
--
M
A
T
--
D
N
I
G
V
E
L
L
A
A
T
P
F
-
R
H
K
I
G
T
R
A
-
T
G
D
I
A
T
V
H
H
L
P
P
T
L
M
A
Q
W
Y
F
G
D
A
----------
S
S
K
F
--
R
P
Y
V
G
A
G
I
N
Y
T
T
F
F
D
N
G
F
N
D
H
-
G
K
E
A
G
L
S
D
---------
L
S
L
K
D
S
W
G
A
A
G
Q
V
G
V
D
Y
--
L
I
N
-----------
R
D
-
W
------------
L
V
N
M
S
V
W
Y
M
D
I
D
T
T
A
N
Y
K
L
-
G
GAQQ
H
----
D
S
V
R
L
-
D
P
W
V
F
M
F
S
A
G
Y
R
F
-------------------------------------
4
HHSearch
30.07
17%
-10
- C3 -
2LHF
-
?
A:
[36-179]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
N
T
G
T
W
G
I
R
A
G
Q
Q
F
--
E
--
Q
---
G
R
Y
Y
A
T
Y
E
N
I
S
D
T
S
S
G
-----
N
K
L
R
Q
Q
N
L
L
G
S
Y
D
A
F
L
P
I
G
D
------------
N
N
T
--
K
L
F
G
G
A
T
L
G
L
V
K
L
E
Q
D
G
K
G
---------
F
K
---------
R
D
S
D
V
G
Y
A
A
G
L
Q
A
G
I
L
Q
--
E
L
S
-----------
K
N
-
A
------------
S
I
E
G
G
Y
R
Y
L
R
T
N
A
S
T
E
-
M
T
P
H
----
G
G
N
KL
G
S
L
D
L
H
S
S
S
Q
F
Y
L
G
A
N
Y
K
F
-------------------------------------
8
HHSearch
28.36
13%
-8
- C3 -
2X27
12
?
X:
[44-175]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
D
T
Q
L
G
L
T
F
T
Y
--
M
F
A
--
D
K
W
G
V
E
L
V
A
A
T
P
F
N
H
Q
V
D
V
K
G
L
L
D
G
K
L
A
D
I
K
Q
L
P
P
T
L
L
L
Q
Y
Y
P
M
G
G
T
---------
N
S
A
F
--
Q
P
Y
G
G
L
G
V
N
Y
T
T
F
F
D
E
D
L
A
S
N
R
K
-
A
Q
G
F
S
S
---------
M
K
L
Q
D
S
W
G
L
A
G
E
L
G
F
D
Y
--
M
L
N
-----------
E
H
-
A
------------
L
F
N
M
A
V
W
Y
M
D
I
D
T
K
A
S
-
I
N
-
G
----
P
----
S
A
L
G
V
N
K
T
K
V
D
V
D
V
D
P
W
V
Y
-------------------------------------
9
HHSearch
24.82
15%
21
- C3 -
2JMM
-
OMPA_ECOLI
A:
[22-115]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Q
L
G
A
G
A
F
G
G
Y
Q
--
V
N
--
P
Y
V
G
F
E
M
----
G
Y
D
W
L
G
R
M
-------
P
R
K
A
Q
G
V
Q
L
T
A
K
L
G
Y
P
K
L
G
T
-----------
D
D
L
--
D
I
Y
T
R
L
G
G
M
V
W
R
A
D
T
S
D
K
D
G
-----
N
-
G
Y
I
---------
S
A
A
E
A
S
V
S
P
V
F
A
G
G
V
E
Y
--
V
I
R
R
-
R
I
T
P
E
I
A
T
R
L
E
-
Y
------------
Q
W
T
N
N
A
S
D
N
G
M
L
S
L
G
V
-
S
Y
-
R
----
F
----
G
Q
G
E
A
A
--------------------------------------------------
11
HHSearch
24.59
15%
13
- C3 -
1QJP
5
OMPA_ECOLI
A:
[32-132]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
N
K
L
G
A
G
A
F
G
G
Y
Q
--
V
N
--
P
Y
V
G
F
E
M
G
Y
--
D
W
L
G
R
M
P
Y
-------
A
Y
K
A
Q
G
V
Q
L
T
A
K
L
G
Y
P
I
--
T
-----------
D
D
L
--
D
I
Y
T
R
L
G
G
M
V
W
R
A
D
T
Y
S
N
V
---------
Y
G
---------
K
N
H
D
T
G
V
S
P
V
F
A
G
G
V
E
Y
--
A
I
T
P
-
E
I
A
T
R
L
E
Y
Q
W
T
-
N
------------
G
M
L
S
L
G
V
S
Y
R
F
G
--------------------------------------------------------------------------
7
HHSearch
24.26
10%
-2
- C3 -
2K0L
-
OMPA_KLEPN
A:
[50-165]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
L
G
A
G
A
F
G
G
Y
Q
--
V
N
--
P
Y
L
G
F
E
M
G
--
Y
D
W
L
G
R
M
A
Y
K
G
S
--
V
D
N
G
A
F
K
A
Q
G
V
Q
L
T
A
K
L
G
Y
P
I
T
D
-----------
D
L
--
D
I
Y
T
R
L
G
G
M
V
W
R
A
D
S
K
G
N
Y
A
S
----
T
G
V
S
R
---------
S
E
H
D
T
G
V
S
P
V
F
A
G
G
V
E
W
--
A
V
T
-----------
R
D
-
I
------------
A
T
R
L
E
Y
Q
W
V
N
N
I
G
D
A
G
-
T
V
-
G
----
T
----
R
P
D
N
G
M
L
S
L
G
V
S
Y
R
F
G
Q
E
D
-------------------------------------
5
HHSearch
23.95
14%
17
- C3 -
3NB3
-
OMPA_ECOLI
A:
[32-143]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
N
K
L
G
A
G
A
F
G
G
Y
Q
--
V
N
--
P
Y
V
G
F
E
M
G
Y
--
D
W
L
G
R
M
P
Y
-------
A
Y
K
A
Q
--
G
V
Q
L
T
A
K
L
G
Y
P
I
T
D
-----------
D
L
--
D
I
Y
T
R
L
G
G
M
V
W
R
A
D
T
Y
S
N
V
Y
---------
G
---------
K
N
H
D
T
G
V
S
P
V
F
A
G
G
V
E
Y
--
A
I
T
-----------
P
E
-
I
------------
A
T
R
L
E
Y
Q
W
T
N
G
M
L
S
L
G
-
V
S
-
Y
----
R
----
F
G
------------------------------------------------------
13
HHSearch
12.37
13%
78
- C3 -
1ORM
-
OMPX_ECOLI
A:
[76-130]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
A
--
S
I
Y
G
V
V
G
V
G
Y
G
K
F
Q
T
T
E
Y
P
T
---------
Y
---------
K
N
D
T
S
D
Y
G
F
S
Y
G
A
G
L
Q
F
--
N
P
M
-----------
E
N
-
V
------------
A
L
D
F
S
Y
E
Q
S
R
I
R
S
V
D
V
-
G
T
-
W
----
I
----
A
G
V
G
Y
R
F
-------------------------------------------------
12
HHSearch
0.00
10%
229
* C3 *
3QRA
3
?
A:
[111-141]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
S
K
T
S
L
A
Y
G
A
G
L
Q
F
--
N
P
H
-----------
P
N
-
F
------------
V
I
D
A
S
Y
E
Y
S
K
L
D
D
V
K
V
-
G
T
-
W
----
M
----
L
G
A
G
Y
R
F
-------------------------------------------------