@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_0840: (2015-12-18 )
MEILVLNLGSSSIKFKLFDMKENKPLASGLAEKIGEEIGQLKIKSHLHHNDQELKEKLVIKDHAIGLLMIRENLTKMGIIKDFNQIDAIGHRVVQGGDKFHAPVLVDEKVMREIGNLSILAPLHNPANLAGIEFVQKAHPHIPQIAVFDTAFHASMPSYAYMYALPYELYEKYQIRRYGFHGTSHHYVAKEAAKFLNIPYEEFNAISLHLGNGSSAAAIQNGKSVDTSMGLTPLEGLIMGTRCGDIDPTVVEYIAQCANKSLEEVMKILNHESGLKGICGDNDARNIEVRKEKGDKQAKLAFEMCVYRIKKYIGAYMVVLKKVDAIIFTGGLGENYSALRESVCEGLENLGIALHKPTNDNPGSALVNLSQPNTKIQILRIPTDEELEIALQAKEMVEKIKVV
Atome Classification :
(33 SA)
.........10........20........30........40--....----....50........60........70....--....--80........90........100.......110.......120.......130.......140.--......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.-........290.......300.......310.......320........330.......340.......350.......360---..-.....370.-......380.......390.......400.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
E
I
L
V
L
NLGSS
S
I
K
F
K
L
F
DMKENK
P
L
A
S
G
L
A
E
K
I
G
E
E
I
G
Q
L
--
K
I
K
S
----HLHH
N
D
Q
E
L
K
E
K
L
V
IKDH
A
I
G
L
L
M
I
R
EN
L
T
--KMG
I
--
I
K
D
F
N
Q
I
D
A
I
G
H
R
V
VQGGDKFHA
P
V
LV
D
E
K
V
M
R
E
IGN
L
S
I
L
APLHNPA
N
L
A
G
I
E
F
V
Q
K
AHPHI
P
--
Q
I
A
V
F
D
T
A
F
HASMPS
Y
A
Y
MYAL
P
Y
E
L
Y
E
K
Y
Q
I
R
R
YGFHGTS
H
H
Y
V
A
K
E
A
A
K
F
LNI
P
Y
E
EF
N
A
I
S
L
H
LGNGSS
A
A
A
IQNGKSVDTSMGL
T
P
L
E
G
L
I
MGTRCGDI
D
P
T
V
V
E
Y
I
A
Q
C
A
N
K
S
L
E
E
V
M
K
I
LNHESGLKGICG--D-NDAR
N
I
E
V
R
KEKG
D
K
Q
A
K
L
A
F
E
M
C
V
Y
R
I
K
K
Y
I
G
A
Y
M
V
V
L
K
-KV
D
A
I
I
F
TGGLGE
N
Y
S
A
L
R
E
S
V
C
E
G
L
E
NL
G
I
A
L
HKPTNDNP---G
S
-
A
L
V
NLSQPN-
T
K
I
Q
I
L
RIPTD
E
E
L
E
I
A
L
Q
A
K
E
M
V
E
KIKVV
43
Fugue
96.34
46%
-94
- C5 -
1G99
2
ACKA_METTE
A:
[1-398]
M
K
V
L
V
I
N
A
G
S
S
S
L
K
Y
Q
L
I
D
M
T
N
E
S
A
L
A
V
G
L
C
E
R
I
G
I
D
N
S
I
I
--
T
Q
K
K
----
F
---
D
G
K
K
L
E
K
L
T
D
L
P
T
H
K
D
A
L
E
E
V
V
K
A
L
T
DD
E
F
G
V
--
I
K
D
M
G
E
I
N
A
V
G
H
R
V
V
H
G
G
E
K
F
T
T
S
A
L
Y
D
E
G
V
E
K
A
I
K
D
C
F
E
L
A
P
L
H
N
P
P
N
M
M
G
I
S
A
C
A
E
I
M
P
G
T
P
--
M
V
I
V
F
D
T
A
F
H
Q
T
M
P
P
Y
A
Y
M
Y
A
L
P
Y
D
L
Y
E
K
H
G
V
R
K
Y
G
F
H
G
T
S
H
K
Y
V
A
E
R
A
A
L
M
L
G
K
P
A
E
E
T
K
I
I
T
C
H
L
G
N
G
S
S
I
T
A
V
E
G
G
K
S
V
E
T
S
M
G
F
T
P
L
E
G
L
A
M
G
T
R
C
G
S
I
D
P
A
I
V
P
F
L
M
E
K
E
G
L
T
T
R
E
I
D
T
L
M
N
K
K
S
G
V
L
G
V
S
G
L-
S
-
N
D
F
R
D
L
D
E
A
A
S
K
G
N
R
K
A
E
L
A
L
E
I
F
A
Y
K
V
K
K
F
I
G
E
Y
S
A
V
L
N
-
G
A
D
A
V
V
F
T
A
G
I
G
E
N
S
A
S
I
R
K
R
I
L
T
G
L
D
G
I
G
I
K
I
D
D
E
K
N
K
I
R
---
G
Q
-
E
-
I
D
I
S
T
P
D
-
A
K
V
R
V
F
V
I
P
T
N
E
E
L
A
I
A
R
E
T
K
E
I
V
E
T
----
1
PsiBlast_PDB
96.30
49%
-101
- C5 -
2IIR
-
ACKA_THEMA
A:
[1-400]
M
R
V
L
V
I
N
S
G
S
S
S
I
K
Y
Q
L
I
E
M
E
G
E
K
V
L
C
K
G
I
A
E
R
I
G
I
E
G
S
R
L
V
H
R
V
G
D
----
E
K
H
V
I
E
R
E
L
P
------
D
H
E
E
A
L
K
L
I
L
N
T
L
V
DE
K
L
G
V
--
I
K
D
L
K
E
I
D
A
V
G
H
R
V
V
H
G
G
E
R
F
K
E
S
V
L
V
D
E
E
V
L
K
A
I
E
E
V
S
P
L
A
P
L
H
N
P
A
N
L
M
G
I
K
A
A
M
K
L
L
P
G
V
P
--
N
V
A
V
F
D
T
A
F
H
Q
T
I
P
Q
K
A
Y
L
Y
A
I
P
Y
E
Y
Y
E
K
Y
K
I
R
R
Y
G
F
H
G
T
S
H
R
Y
V
S
K
R
A
A
E
I
L
G
K
K
L
E
E
L
K
I
I
T
C
H
I
G
N
G
A
S
V
A
A
V
K
Y
G
K
C
V
D
T
S
M
G
F
T
P
L
E
G
L
V
M
G
T
R
S
G
D
L
D
P
A
I
P
F
F
I
M
E
K
E
G
I
S
P
Q
E
M
Y
D
I
L
N
K
K
S
G
V
Y
G
L
S
K
GF
S
-
S
D
M
R
D
I
E
E
A
A
L
K
G
D
E
W
C
K
L
V
L
E
I
Y
D
Y
R
I
A
K
Y
I
G
A
Y
A
A
A
M
N
-
G
V
D
A
I
V
F
T
A
G
V
G
E
N
S
P
I
T
R
E
D
V
C
S
Y
L
E
F
L
G
V
K
L
D
K
Q
K
N
E
E
T
IR-
G
K
-
E
G
I
-
I
S
T
P
D
-
S
R
V
K
V
L
V
V
P
T
N
E
E
L
M
I
A
R
D
T
K
E
I
V
E
K
----
53
HHSearch
94.88
46%
-93
- C5 -
1G99
2
ACKA_METTE
A:
[1-398]
M
K
V
L
V
I
N
A
G
S
S
S
L
K
Y
Q
L
I
D
M
T
N
E
S
A
L
A
V
G
L
C
E
R
I
G
I
D
N
S
I
I
--
T
Q
K
K
----
F
D
---
G
K
K
L
E
K
L
T
D
L
P
T
H
K
D
A
L
E
E
V
V
K
A
L
T
--
D
D
E
F
GV
I
K
D
M
G
E
I
N
A
V
G
H
R
V
V
H
G
G
E
K
F
T
T
S
A
L
Y
D
E
G
V
E
K
A
I
K
D
C
F
E
L
A
P
L
H
N
P
P
N
M
M
G
I
S
A
C
A
E
I
M
P
G
T
P
--
M
V
I
V
F
D
T
A
F
H
Q
T
M
P
P
Y
A
Y
M
Y
A
L
P
Y
D
L
Y
E
K
H
G
V
R
K
Y
G
F
H
G
T
S
H
K
Y
V
A
E
R
A
A
L
M
L
G
K
P
A
E
E
T
K
I
I
T
C
H
L
G
N
G
S
S
I
T
A
V
E
G
G
K
S
V
E
T
S
M
G
F
T
P
L
E
G
L
A
M
G
T
R
C
G
S
I
D
P
A
I
V
P
F
L
M
E
K
E
G
L
T
T
R
E
I
D
T
L
M
N
K
K
S
G
V
L
G
V
S
G
--
L
S
N
D
F
R
D
L
D
E
A
A
S
K
G
N
R
K
A
E
L
A
L
E
I
F
A
Y
K
V
K
K
F
I
G
E
Y
S
A
V
L
N
-
G
A
D
A
V
V
F
T
A
G
I
G
E
N
S
A
S
I
R
K
R
I
L
T
G
L
D
G
I
G
I
K
I
D
D
E
K
N
K
I
R
---
G
--
Q
E
I
D
I
S
T
P
D
-
A
K
V
R
V
F
V
I
P
T
N
E
E
L
A
I
A
R
E
T
K
E
I
V
E
T
----
3
PsiBlast_PDB
94.66
45%
-95
- C5 -
1TUY
2
ACKA_METTE
A:
[1-397]
M
K
V
L
V
I
N
A
G
S
S
S
L
K
Y
Q
L
I
D
M
T
N
E
S
A
L
A
V
G
L
C
E
R
I
G
I
D
---
N
--
S
I
I
T
----
Q
K
K
F
D
G
K
K
L
E
K
L
T
D
L
P
T
H
K
D
A
L
E
E
V
V
K
A
L
T
DD
E
F
G
V
--
I
K
D
M
G
E
I
N
A
V
G
H
R
V
V
H
G
G
E
K
F
T
T
S
A
L
Y
D
E
G
V
E
K
A
I
K
D
C
F
E
L
A
P
L
H
N
P
P
N
M
M
G
I
S
A
C
A
E
I
M
P
G
T
P
--
M
V
I
V
F
D
T
A
F
H
Q
T
M
P
P
Y
A
Y
M
Y
A
L
P
Y
D
L
Y
E
K
H
G
V
R
K
Y
G
F
H
G
T
S
H
K
Y
V
A
E
R
A
A
L
M
L
G
K
P
A
E
E
T
K
I
I
T
C
H
L
G
N
G
S
S
I
T
A
V
E
G
G
K
S
V
E
T
S
M
G
F
T
P
L
E
G
L
A
M
G
T
R
C
G
S
I
D
P
A
I
V
P
F
L
M
E
K
E
G
L
T
T
R
E
I
D
T
L
M
N
K
K
S
G
V
L
G
V
S
G
L-
S
-
N
D
F
R
D
L
D
E
A
A
S
K
G
N
R
K
A
E
L
A
L
E
I
F
A
Y
K
V
K
K
F
I
G
E
Y
S
A
V
L
N
-
G
A
D
A
V
V
F
T
A
G
I
G
E
N
S
A
S
I
R
K
R
I
L
T
G
L
D
G
I
G
I
K
I
D
D
E
K
N
K
I
R
---
G
Q
-
E
-
I
D
I
S
T
P
D
-
A
K
V
R
V
F
V
I
P
T
N
E
E
L
A
I
A
R
E
T
K
E
I
V
E
T
E
---
4
PsiBlast_PDB
94.57
45%
-91
- C5 -
1G99
2
ACKA_METTE
A:
[1-397]
M
K
V
L
V
I
N
A
G
S
S
S
L
K
Y
Q
L
I
D
M
T
N
E
S
A
L
A
V
G
L
C
E
R
I
G
I
D
---
N
--
S
I
I
T
----
Q
K
K
F
D
G
K
K
L
E
K
L
T
D
L
P
T
H
K
D
A
L
E
E
V
V
K
A
L
T
DD
E
F
G
V
--
I
K
D
M
G
E
I
N
A
V
G
H
R
V
V
H
G
G
E
K
F
T
T
S
A
L
Y
D
E
G
V
E
K
A
I
K
D
C
F
E
L
A
P
L
H
N
P
P
N
M
M
G
I
S
A
C
A
E
I
M
P
G
T
P
--
M
V
I
V
F
D
T
A
F
H
Q
T
M
P
P
Y
A
Y
M
Y
A
L
P
Y
D
L
Y
E
K
H
G
V
R
K
Y
G
F
H
G
T
S
H
K
Y
V
A
E
R
A
A
L
M
L
G
K
P
A
E
E
T
K
I
I
T
C
H
L
G
N
G
S
S
I
T
A
V
E
G
G
K
S
V
E
T
S
M
G
F
T
P
L
E
G
L
A
M
G
T
R
C
G
S
I
D
P
A
I
V
P
F
L
M
E
K
E
G
L
T
T
R
E
I
D
T
L
M
N
K
K
S
G
V
L
G
V
S
G
L-
S
-
N
D
F
R
D
L
D
E
A
A
S
K
G
N
R
K
A
E
L
A
L
E
I
F
A
Y
K
V
K
K
F
I
G
E
Y
S
A
V
L
N
-
G
A
D
A
V
V
F
T
A
G
I
G
E
N
S
A
S
I
R
K
R
I
L
T
G
L
D
G
I
G
I
K
I
D
D
E
K
N
K
I
R
---
G
Q
-
E
-
I
D
I
S
T
P
D
-
A
K
V
R
V
F
V
I
P
T
N
E
E
L
A
I
A
R
E
T
K
E
I
V
E
T
----
55
HHSearch
94.50
50%
-97
* C5 *
2IIR
-
ACKA_THEMA
A:
[1-400]
M
R
V
L
V
I
N
S
G
S
S
S
I
K
Y
Q
L
I
E
M
E
G
E
K
V
L
C
K
G
I
A
E
R
I
G
I
E
G
S
R
L
--
V
H
R
V
----
G
D
---
E
K
H
V
I
-
E
R
E
L
P
D
H
E
E
A
L
K
L
I
L
N
T
L
V
--
D
E
K
L
GV
I
K
D
L
K
E
I
D
A
V
G
H
R
V
V
H
G
G
E
R
F
K
E
S
V
L
V
D
E
E
V
L
K
A
I
E
E
V
S
P
L
A
P
L
H
N
P
A
N
L
M
G
I
K
A
A
M
K
L
L
P
G
V
P
--
N
V
A
V
F
D
T
A
F
H
Q
T
I
P
Q
K
A
Y
L
Y
A
I
P
Y
E
Y
Y
E
K
Y
K
I
R
R
Y
G
F
H
G
T
S
H
R
Y
V
S
K
R
A
A
E
I
L
G
K
K
L
E
E
L
K
I
I
T
C
H
I
G
N
G
A
S
V
A
A
V
K
Y
G
K
C
V
D
T
S
M
G
F
T
P
L
E
G
L
V
M
G
T
R
S
G
D
L
D
P
A
I
P
F
F
I
M
E
K
E
G
I
S
P
Q
E
M
Y
D
I
L
N
K
K
S
G
V
Y
G
L
S
K
GF
S
-
S
D
M
R
D
I
E
E
A
A
L
K
G
D
E
W
C
K
L
V
L
E
I
Y
D
Y
R
I
A
K
Y
I
G
A
Y
A
A
A
M
N
-
G
V
D
A
I
V
F
T
A
G
V
G
E
N
S
P
I
T
R
E
D
V
C
S
Y
L
E
F
L
G
V
K
L
D
K
Q
K
N
E
E
T
---
I
R
G
K
E
G
I
I
S
T
P
D
-
S
R
V
K
V
L
V
V
P
T
N
E
E
L
M
I
A
R
D
T
K
E
I
V
E
K
----
23
PsiBlast_CBE
93.89
45%
-94
- C5 -
1G99
2
ACKA_METTE
B:
[1-397]
M
K
V
L
V
I
N
A
G
S
S
S
L
K
Y
Q
L
I
D
M
T
N
E
S
A
L
A
V
G
L
C
E
R
I
G
I
D
---
N
--
S
I
I
T
----
Q
K
K
F
D
G
K
K
L
E
K
L
T
D
L
P
T
H
K
D
A
L
E
E
V
V
K
A
L
T
DD
E
F
G
V
--
I
K
D
M
G
E
I
N
A
V
G
H
R
V
V
H
G
G
E
K
F
T
T
S
A
L
Y
D
E
G
V
E
K
A
I
K
D
C
F
E
L
A
P
L
H
N
P
P
N
M
M
G
I
S
A
C
A
E
I
M
P
G
T
P
--
M
V
I
V
F
D
T
A
F
H
Q
T
M
P
P
Y
A
Y
M
Y
A
L
P
Y
D
L
Y
E
K
H
G
V
R
K
Y
G
F
H
G
T
S
H
K
Y
V
A
E
R
A
A
L
M
L
G
K
P
A
E
E
T
K
I
I
T
C
H
L
G
N
G
S
S
I
T
A
V
E
G
G
K
S
V
E
T
S
M
G
F
T
P
L
E
G
L
A
M
G
T
R
C
G
S
I
D
P
A
I
V
P
F
L
M
E
K
E
G
L
T
T
R
E
I
D
T
L
M
N
K
K
S
G
V
L
G
V
S
G
L-
S
-
N
D
F
R
D
L
D
E
A
A
S
K
G
N
R
K
A
E
L
A
L
E
I
F
A
Y
K
V
K
K
F
I
G
E
Y
S
A
V
L
N
-
G
A
D
A
V
V
F
T
A
G
I
G
E
N
S
A
S
I
R
K
R
I
L
T
G
L
D
G
I
G
I
K
I
D
D
E
K
N
K
I
R
---
G
Q
-
E
-
I
D
I
S
T
P
D
-
A
K
V
R
V
F
V
I
P
T
N
E
E
L
A
I
A
R
E
T
K
E
I
V
E
T
----
22
PsiBlast_CBE
93.30
45%
-94
- C5 -
1TUU
3
ACKA_METTE
B:
[1-397]
M
K
V
L
V
I
N
A
G
S
S
S
L
K
Y
Q
L
I
D
M
T
N
E
S
A
L
A
V
G
L
C
E
R
I
G
I
D
---
N
--
S
I
I
T
----
Q
K
K
F
D
G
K
K
L
E
K
L
T
D
L
P
T
H
K
D
A
L
E
E
V
V
K
A
L
T
DD
E
F
G
V
--
I
K
D
M
G
E
I
N
A
V
G
H
R
V
V
H
G
G
E
K
F
T
T
S
A
L
Y
D
E
G
V
E
K
A
I
K
D
C
F
E
L
A
P
L
H
N
P
P
N
M
M
G
I
S
A
C
A
E
I
M
P
G
T
P
--
M
V
I
V
F
D
T
A
F
H
Q
T
M
P
P
Y
A
Y
M
Y
A
L
P
Y
D
L
Y
E
K
H
G
V
R
K
Y
G
F
H
G
T
S
H
K
Y
V
A
E
R
A
A
L
M
L
G
K
P
A
E
E
T
K
I
I
T
C
H
L
G
N
G
S
S
I
T
A
V
E
G
G
K
S
V
E
T
S
M
G
F
T
P
L
E
G
L
A
M
G
T
R
C
G
S
I
D
P
A
I
V
P
F
L
M
E
K
E
G
L
T
T
R
E
I
D
T
L
M
N
K
K
S
G
V
L
G
V
S
G
L-
S
-
N
D
F
R
D
L
D
E
A
A
S
K
G
N
R
K
A
E
L
A
L
E
I
F
A
Y
K
V
K
K
F
I
G
E
Y
S
A
V
L
N
-
G
A
D
A
V
V
F
T
A
G
I
G
E
N
S
A
S
I
R
K
R
I
L
T
G
L
D
G
I
G
I
K
I
D
D
E
K
N
K
I
R
---
G
Q
-
E
-
I
D
I
S
T
P
D
-
A
K
V
R
V
F
V
I
P
T
N
E
E
L
A
I
A
R
E
T
K
E
I
V
E
T
----
57
HHSearch
93.15
44%
-102
- C5 -
3R9P
3
ACKA_MYCPA
A:
[12-390]
R
R
V
L
V
I
N
S
G
S
S
S
L
K
F
Q
L
V
D
P
E
F
G
V
A
A
S
T
G
I
V
E
R
I
G
E
E
S
-------------------------
S
P
V
P
D
H
D
A
A
L
R
R
A
F
D
M
L
A
--
G
D
G
V
--
D
L
N
T
A
G
L
V
A
V
G
H
R
V
V
H
G
G
N
T
F
Y
R
P
T
V
L
D
D
A
V
I
A
R
L
H
E
L
S
E
L
A
P
L
H
N
P
P
A
L
Q
G
I
E
V
A
R
R
L
L
P
D
I
A
--
H
V
A
V
F
D
T
G
F
F
H
D
L
P
P
A
A
A
T
Y
A
I
D
R
E
L
A
D
R
W
Q
I
R
R
Y
G
F
H
G
T
S
H
R
Y
V
S
E
Q
A
A
A
F
L
D
R
P
L
R
G
L
K
Q
I
V
L
H
L
G
N
G
C
S
A
S
A
I
A
G
T
R
P
L
D
T
S
M
G
L
T
P
L
E
G
L
V
M
G
T
R
S
G
D
I
D
P
S
I
V
S
Y
L
C
H
T
A
G
M
G
V
D
D
V
E
S
M
L
N
H
R
S
G
V
V
G
L
S
G
--
V
-
R
D
F
R
R
L
R
E
L
I
E
S
G
D
G
A
A
Q
L
A
Y
S
V
F
T
H
R
L
R
K
Y
I
G
A
Y
L
A
V
L
G
-
H
T
D
V
I
S
F
T
A
G
I
G
E
N
D
A
A
V
R
R
D
A
V
S
G
M
E
E
L
G
I
V
L
D
E
R
R
N
L
A
G
---
G
K
-
G
A
R
Q
I
S
A
D
D
-
S
P
I
T
V
L
V
V
P
T
N
E
E
L
A
I
A
R
D
C
V
R
V
L
G
G
----
2
PsiBlast_PDB
93.11
45%
-88
- C5 -
1TUU
2
ACKA_METTE
A:
[1-397]
M
K
V
L
V
I
N
A
G
S
S
S
L
K
Y
Q
L
I
D
M
T
N
E
S
A
L
A
V
G
L
C
E
R
I
G
I
D
---
N
--
S
I
I
T
----
Q
K
K
F
D
G
K
K
L
E
K
L
T
D
L
P
T
H
K
D
A
L
E
E
V
V
K
A
L
T
DD
E
F
G
V
--
I
K
D
M
G
E
I
N
A
V
G
H
R
V
V
H
G
G
E
K
F
T
T
S
A
L
Y
D
E
G
V
E
K
A
I
K
D
C
F
E
L
A
P
L
H
N
P
P
N
M
M
G
I
S
A
C
A
E
I
M
P
G
T
P
--
M
V
I
V
F
D
T
A
F
H
Q
T
M
P
P
Y
A
Y
M
Y
A
L
P
Y
D
L
Y
E
K
H
G
V
R
K
Y
G
F
H
G
T
S
H
K
Y
V
A
E
R
A
A
L
M
L
G
K
P
A
E
E
T
K
I
I
T
C
H
L
G
N
G
S
S
I
T
A
V
E
G
G
K
S
V
E
T
S
M
G
F
T
P
L
E
G
L
A
M
G
T
R
C
G
S
I
D
P
A
I
V
P
F
L
M
E
K
E
G
L
T
T
R
E
I
D
T
L
M
N
K
K
S
G
V
L
G
V
S
G
L-
S
-
N
D
F
R
D
L
D
E
A
A
S
K
G
N
R
K
A
E
L
A
L
E
I
F
A
Y
K
V
K
K
F
I
G
E
Y
S
A
V
L
N
-
G
A
D
A
V
V
F
T
A
G
I
G
E
N
S
A
S
I
R
K
R
I
L
T
G
L
D
G
I
G
I
K
I
D
D
E
K
N
K
I
R
---
G
Q
-
E
-
I
D
I
S
T
P
D
-
A
K
V
R
V
F
V
I
P
T
N
E
E
L
A
I
A
R
E
T
K
E
I
V
E
T
E
---
21
PsiBlast_CBE
92.78
45%
-93
- C5 -
1TUY
3
ACKA_METTE
B:
[1-397]
M
K
V
L
V
I
N
A
G
S
S
S
L
K
Y
Q
L
I
D
M
T
N
E
S
A
L
A
V
G
L
C
E
R
I
G
I
D
---
N
--
S
I
I
T
----
Q
K
K
F
D
G
K
K
L
E
K
L
T
D
L
P
T
H
K
D
A
L
E
E
V
V
K
A
L
T
DD
E
F
G
V
--
I
K
D
M
G
E
I
N
A
V
G
H
R
V
V
H
G
G
E
K
F
T
T
S
A
L
Y
D
E
G
V
E
K
A
I
K
D
C
F
E
L
A
P
L
H
N
P
P
N
M
M
G
I
S
A
C
A
E
I
M
P
G
T
P
--
M
V
I
V
F
D
T
A
F
H
Q
T
M
P
P
Y
A
Y
M
Y
A
L
P
Y
D
L
Y
E
K
H
G
V
R
K
Y
G
F
H
G
T
S
H
K
Y
V
A
E
R
A
A
L
M
L
G
K
P
A
E
E
T
K
I
I
T
C
H
L
G
N
G
S
S
I
T
A
V
E
G
G
K
S
V
E
T
S
M
G
F
T
P
L
E
G
L
A
M
G
T
R
C
G
S
I
D
P
A
I
V
P
F
L
M
E
K
E
G
L
T
T
R
E
I
D
T
L
M
N
K
K
S
G
V
L
G
V
S
G
L-
S
-
N
D
F
R
D
L
D
E
A
A
S
K
G
N
R
K
A
E
L
A
L
E
I
F
A
Y
K
V
K
K
F
I
G
E
Y
S
A
V
L
N
-
G
A
D
A
V
V
F
T
A
G
I
G
E
N
S
A
S
I
R
K
R
I
L
T
G
L
D
G
I
G
I
K
I
D
D
E
K
N
K
I
R
---
G
Q
-
E
-
I
D
I
S
T
P
D
-
A
K
V
R
V
F
V
I
P
T
N
E
E
L
A
I
A
R
E
T
K
E
I
V
E
T
----
8
PsiBlast_PDB
91.75
43%
-102
- C5 -
4IZ9
7
ACKA_MYCA1
A:
[14-383]
-
R
V
L
V
I
N
S
G
S
S
S
L
K
F
Q
L
V
D
P
E
S
G
V
A
A
S
T
G
I
V
E
R
I
G
E
--
S
P
-------------------------
V
P
D
H
D
A
A
L
R
R
A
F
D
M
L
A
--
G
D
G
V
--
D
L
N
T
A
G
L
V
A
V
G
H
R
V
V
H
G
G
N
T
F
Y
R
P
T
V
L
D
D
A
V
I
A
R
L
H
E
L
S
E
L
A
P
L
H
N
P
P
A
L
L
G
I
E
V
A
R
R
L
L
P
G
I
A
--
H
V
A
V
F
D
T
G
F
F
H
D
L
P
P
A
A
A
T
Y
A
I
D
R
E
L
A
D
R
W
Q
I
R
R
Y
G
F
H
G
T
S
H
R
Y
V
S
E
Q
A
A
A
F
L
D
R
P
L
R
G
L
K
Q
I
V
L
H
L
G
N
G
C
S
A
S
A
I
A
G
T
R
P
L
D
T
S
M
G
L
T
P
L
E
G
L
V
M
G
T
R
S
G
D
I
D
P
S
V
V
S
Y
L
C
H
T
A
G
M
G
V
D
D
V
E
S
M
L
N
H
R
S
G
V
V
G
L
S
G
--
V
-
R
D
F
R
R
L
R
E
L
I
E
S
G
D
G
A
A
Q
L
A
Y
S
V
F
T
H
R
L
R
K
Y
I
G
A
Y
L
A
V
L
G
-
H
T
D
V
I
S
F
T
A
G
I
G
E
N
D
A
A
V
R
R
D
A
V
S
G
M
E
E
L
G
I
V
L
D
E
R
R
N
L
P
G
---
A
K
-
G
A
R
Q
I
S
A
D
D
-
S
P
I
T
V
L
V
V
P
T
N
E
E
L
A
I
A
R
D
C
V
R
V
L
G
G
----
5
PsiBlast_PDB
90.83
43%
-100
- C5 -
3R9P
3
ACKA_MYCPA
A:
[13-382]
-
R
V
L
V
I
N
S
G
S
S
S
L
K
F
Q
L
V
D
P
E
F
G
V
A
A
S
T
G
I
V
E
R
I
G
E
E
S
S
P
-------------------------
V
P
D
H
D
A
A
L
R
R
A
F
D
M
L
A
--
G
D
G
V
--
D
L
N
T
A
G
L
V
A
V
G
H
R
V
V
H
G
G
N
T
F
Y
R
P
T
V
L
D
D
A
V
I
A
R
L
H
E
L
S
E
L
A
P
L
H
N
P
P
A
L
Q
G
I
E
V
A
R
R
L
L
P
D
I
A
--
H
V
A
V
F
D
T
G
F
F
H
D
L
P
P
A
A
A
T
Y
A
I
D
R
E
L
A
D
R
W
Q
I
R
R
Y
G
F
H
G
T
S
H
R
Y
V
S
E
Q
A
A
A
F
L
D
R
P
L
R
G
L
K
Q
I
V
L
H
L
G
N
G
C
S
A
S
A
I
A
G
T
R
P
L
D
T
S
M
G
L
T
P
L
E
G
L
V
M
G
T
R
S
G
D
I
D
P
S
I
V
S
Y
L
C
H
T
A
G
M
G
V
D
D
V
E
S
M
L
N
H
R
S
G
V
V
G
L
S
G
--
V
-
R
D
F
R
R
L
R
E
L
I
E
S
G
D
G
A
A
Q
L
A
Y
S
V
F
T
H
R
L
R
K
Y
I
G
A
Y
L
A
V
L
G
-
H
T
D
V
I
S
F
T
A
G
I
G
E
N
D
A
A
V
R
R
D
A
V
S
G
M
E
E
L
G
I
V
L
D
E
R
R
N
L
A
G
---
G
K
-
G
A
R
Q
I
S
A
D
D
-
S
P
I
T
V
L
V
V
P
T
N
E
E
L
A
I
A
R
D
C
V
R
V
L
G
G
----
9
PsiBlast_PDB
90.79
42%
-104
- C5 -
4DQ8
-
ACKA_MYCMM
A:
[10-378]
--
V
L
V
L
N
S
G
S
S
S
L
K
F
Q
L
V
E
P
D
S
G
M
S
R
A
T
G
N
I
E
R
I
--------------------------------
P
D
H
D
A
A
L
R
R
V
F
E
I
L
A
--
E
D
D
I
--
D
L
Q
S
C
G
L
V
A
V
G
H
R
V
V
H
G
G
K
D
F
Y
E
P
T
L
L
N
D
A
V
I
G
K
L
D
E
L
S
P
L
A
P
L
H
N
P
P
A
V
L
C
I
R
V
A
R
A
L
L
P
D
V
P
--
H
I
A
V
F
D
T
A
F
F
H
Q
L
P
P
A
A
A
T
Y
A
I
D
R
E
L
A
D
V
W
K
I
R
R
Y
G
F
H
G
T
S
H
E
Y
V
S
Q
Q
A
A
E
F
L
G
K
P
I
G
D
L
N
Q
I
V
L
H
L
G
N
G
A
S
A
S
A
V
A
G
G
R
P
V
E
T
S
M
G
L
T
P
L
E
G
L
V
M
G
T
R
S
G
D
L
D
P
G
V
I
G
Y
L
W
R
T
A
K
L
G
V
D
E
I
E
S
M
L
N
H
R
S
G
M
L
G
L
A
G
--
E
-
R
D
F
R
R
L
R
A
M
I
D
D
G
D
P
A
A
E
L
A
Y
D
V
F
I
H
R
L
R
K
Y
V
G
A
Y
L
A
V
L
G
-
H
T
D
V
V
S
F
T
A
G
I
G
E
H
D
A
A
V
R
R
D
T
L
A
G
M
A
E
L
G
I
S
L
D
E
R
R
N
A
C
P
---
S
G
-
G
A
R
R
I
S
A
D
D
-
S
P
V
T
V
L
V
I
P
T
N
E
E
L
A
I
A
R
H
C
C
S
V
L
V
-----
7
PsiBlast_PDB
90.67
43%
-102
- C5 -
3P4I
1
ACKA_MYCA1
A:
[14-383]
-
R
V
L
V
I
N
S
G
S
S
S
L
K
F
Q
L
V
D
P
E
S
G
V
A
A
S
T
G
I
V
E
R
I
--
E
S
S
P
-------------------------
V
P
D
H
D
A
A
L
R
R
A
F
D
M
L
A
--
G
D
G
V
--
D
L
N
T
A
G
L
V
A
V
G
H
R
V
V
H
G
G
N
T
F
Y
R
P
T
V
L
D
D
A
V
I
A
R
L
H
E
L
S
E
L
A
P
L
H
N
P
P
A
L
L
G
I
E
V
A
R
R
L
L
P
G
I
A
--
H
V
A
V
F
D
T
G
F
F
H
D
L
P
P
A
A
A
T
Y
A
I
D
R
E
L
A
D
R
W
Q
I
R
R
Y
G
F
H
G
T
S
H
R
Y
V
S
E
Q
A
A
A
F
L
D
R
P
L
R
G
L
K
Q
I
V
L
H
L
G
N
G
C
S
A
S
A
I
A
G
T
R
P
L
D
T
S
M
G
L
T
P
L
E
G
L
V
M
G
T
R
S
G
D
I
D
P
S
V
V
S
Y
L
C
H
T
A
G
M
G
V
D
D
V
E
S
M
L
N
H
R
S
G
V
V
G
L
S
G
--
V
-
R
D
F
R
R
L
R
E
L
I
E
S
G
D
G
A
A
Q
L
A
Y
S
V
F
T
H
R
L
R
K
Y
I
G
A
Y
L
A
V
L
G
-
H
T
D
V
I
S
F
T
A
G
I
G
E
N
D
A
A
V
R
R
D
A
V
S
G
M
E
E
L
G
I
V
L
D
E
R
R
N
L
P
G
---
A
K
-
G
A
R
Q
I
S
A
D
D
-
S
P
I
T
V
L
V
V
P
T
N
E
E
L
A
I
A
R
D
C
V
R
V
L
G
G
----
6
PsiBlast_PDB
90.67
42%
-100
- C5 -
4IJN
4
ACKA_MYCS2
A:
[23-391]
V
T
V
L
V
V
N
S
G
S
S
S
L
K
Y
A
V
V
R
P
A
S
G
E
F
L
A
D
G
I
I
E
E
I
G
S
G
---------------------------
A
V
P
D
H
D
A
A
L
R
A
A
F
D
E
L
A
--
A
A
G
L
--
H
L
E
D
L
D
L
K
A
V
G
H
R
M
V
H
G
G
K
T
F
Y
K
P
S
V
V
D
D
E
L
I
A
K
A
R
E
L
S
P
L
A
P
L
H
N
P
P
A
I
K
G
I
E
V
A
R
K
L
L
P
D
L
P
--
H
I
A
V
F
D
T
A
F
F
H
D
L
P
A
P
A
S
T
Y
A
I
D
R
E
L
A
E
T
W
H
I
K
R
Y
G
F
H
G
T
S
H
E
Y
V
S
Q
Q
A
A
I
F
L
D
R
P
L
E
S
L
N
Q
I
V
L
H
L
G
N
G
A
S
A
S
A
V
A
G
G
K
A
V
D
T
S
M
G
L
T
P
M
E
G
L
V
M
G
T
R
S
G
D
I
D
P
G
V
I
M
Y
L
W
R
T
A
G
M
S
V
D
D
I
E
S
M
L
N
R
R
S
G
V
L
G
L
G
G
--
A
-
S
D
F
R
K
L
R
E
L
I
E
S
G
D
E
H
A
K
L
A
Y
D
V
Y
I
H
R
L
R
K
Y
I
G
A
Y
M
A
V
L
G
-
R
T
D
V
I
S
F
T
A
G
V
G
E
N
V
P
P
V
R
R
D
A
L
A
G
L
G
G
L
G
I
E
I
D
D
A
L
N
S
A
K
---
S
D
-
E
P
R
L
I
S
T
P
D
-
S
R
V
T
V
L
V
V
P
T
N
E
E
L
A
I
A
R
A
C
V
G
V
-------
24
PsiBlast_CBE
90.52
43%
-103
- C5 -
3R9P
1
ACKA_MYCPA
B:
[13-382]
-
R
V
L
V
I
N
S
G
S
S
S
L
K
F
Q
L
V
D
P
E
F
G
V
A
A
S
T
G
I
V
E
R
I
G
E
--
S
P
-------------------------
V
P
D
H
D
A
A
L
R
R
A
F
D
M
L
A
--
G
D
G
V
--
D
L
N
T
A
G
L
V
A
V
G
H
R
V
V
H
G
G
N
T
F
Y
R
P
T
V
L
D
D
A
V
I
A
R
L
H
E
L
S
E
L
A
P
L
H
N
P
P
A
L
Q
G
I
E
V
A
R
R
L
L
P
D
I
A
--
H
V
A
V
F
D
T
G
F
F
H
D
L
P
P
A
A
A
T
Y
A
I
D
R
E
L
A
D
R
W
Q
I
R
R
Y
G
F
H
G
T
S
H
R
Y
V
S
E
Q
A
A
A
F
L
D
R
P
L
R
G
L
K
Q
I
V
L
H
L
G
N
G
C
S
A
S
A
I
A
G
T
R
P
L
D
T
S
M
G
L
T
P
L
E
G
L
V
M
G
T
R
S
G
D
I
D
P
S
I
V
S
Y
L
C
H
T
A
G
M
G
V
D
D
V
E
S
M
L
N
H
R
S
G
V
V
G
L
S
G
--
V
-
R
D
F
R
R
L
R
E
L
I
E
S
G
D
G
A
A
Q
L
A
Y
S
V
F
T
H
R
L
R
K
Y
I
G
A
Y
L
A
V
L
G
-
H
T
D
V
I
S
F
T
A
G
I
G
E
N
D
A
A
V
R
R
D
A
V
S
G
M
E
E
L
G
I
V
L
D
E
R
R
N
L
A
G
---
G
K
-
G
A
R
Q
I
S
A
D
D
-
S
P
I
T
V
L
V
V
P
T
N
E
E
L
A
I
A
R
D
C
V
R
V
L
G
G
----
25
PsiBlast_CBE
90.34
42%
-98
- C5 -
4IJN
3
ACKA_MYCS2
B:
[23-391]
V
T
V
L
V
V
N
S
G
S
S
S
L
K
Y
A
V
V
R
P
A
S
G
E
F
L
A
D
G
I
I
E
E
I
G
S
G
---------------------------
A
V
P
D
H
D
A
A
L
R
A
A
F
D
E
L
A
--
A
A
G
L
--
H
L
E
D
L
D
L
K
A
V
G
H
R
M
V
H
G
G
K
T
F
Y
K
P
S
V
V
D
D
E
L
I
A
K
A
R
E
L
S
P
L
A
P
L
H
N
P
P
A
I
K
G
I
E
V
A
R
K
L
L
P
D
L
P
--
H
I
A
V
F
D
T
A
F
F
H
D
L
P
A
P
A
S
T
Y
A
I
D
R
E
L
A
E
T
W
H
I
K
R
Y
G
F
H
G
T
S
H
E
Y
V
S
Q
Q
A
A
I
F
L
D
R
P
L
E
S
L
N
Q
I
V
L
H
L
G
N
G
A
S
A
S
A
V
A
G
G
K
A
V
D
T
S
M
G
L
T
P
M
E
G
L
V
M
G
T
R
S
G
D
I
D
P
G
V
I
M
Y
L
W
R
T
A
G
M
S
V
D
D
I
E
S
M
L
N
R
R
S
G
V
L
G
L
G
G
--
A
-
S
D
F
R
K
L
R
E
L
I
E
S
G
D
E
H
A
K
L
A
Y
D
V
Y
I
H
R
L
R
K
Y
I
G
A
Y
M
A
V
L
G
-
R
T
D
V
I
S
F
T
A
G
V
G
E
N
V
P
P
V
R
R
D
A
L
A
G
L
G
G
L
G
I
E
I
D
D
A
L
N
S
A
K
---
S
D
-
E
P
R
L
I
S
T
P
D
-
S
R
V
T
V
L
V
V
P
T
N
E
E
L
A
I
A
R
A
C
V
G
V
-------
12
PsiBlast_PDB
86.23
41%
-86
- C5 -
3SLC
1
ACKA_SALTY
A:
[21-414]
--
V
L
V
L
N
C
G
S
S
S
L
K
F
A
I
I
D
A
V
N
G
D
E
Y
L
S
G
L
A
E
C
F
--
H
L
P
E
A
--
R
I
K
W
----
K
M
D
G
S
K
Q
E
A
A
L
G
A
G
A
A
H
S
E
A
L
N
F
I
V
N
T
I
L
A
--
Q
K
P
E
--
L
S
--
A
Q
L
T
A
I
G
H
R
I
V
H
G
G
E
K
Y
T
S
S
V
V
I
D
E
S
V
I
Q
G
I
K
D
S
A
S
F
A
P
L
H
N
P
A
H
L
I
G
I
A
E
A
L
K
S
F
P
Q
L
K
DK
N
V
A
V
F
D
T
A
F
H
Q
T
M
P
E
E
S
Y
L
Y
A
L
P
Y
S
L
Y
K
E
H
G
V
R
R
Y
G
A
H
G
T
S
H
F
Y
V
T
Q
E
A
A
K
M
L
N
K
P
V
E
E
L
N
I
I
T
C
H
L
G
N
G
G
S
V
S
A
I
R
N
G
K
C
V
D
T
S
M
G
L
T
P
L
E
G
L
V
M
G
T
R
S
G
D
I
D
P
A
I
I
F
H
L
H
D
T
L
G
M
S
V
D
Q
I
N
K
M
L
T
K
E
S
G
L
L
G
L
T
E
V-
T
-
S
D
C
R
Y
V
E
-
D
N
Y
A
T
K
E
D
A
K
R
A
M
D
V
Y
C
H
R
L
A
K
Y
I
G
S
Y
T
A
L
M
D
G
R
L
D
A
V
V
F
T
G
G
I
G
E
N
A
A
M
V
R
E
L
S
L
G
K
L
G
V
L
G
F
E
V
D
H
E
R
N
L
A
A
RFG
K
S
-
G
F
I
N
--
K
E
G
-
T
R
P
A
V
V
-
I
P
T
N
E
E
L
V
I
A
Q
D
A
S
R
L
T
A
-----
27
PsiBlast_CBE
86.07
41%
-84
- C5 -
3SLC
3
ACKA_SALTY
B:
[21-414]
--
V
L
V
L
N
C
G
S
S
S
L
K
F
A
I
I
D
A
V
N
G
D
E
Y
L
S
G
L
A
E
C
F
--
H
L
P
E
A
--
R
I
K
W
----
K
M
D
G
S
K
Q
E
A
A
L
G
A
G
A
A
H
S
E
A
L
N
F
I
V
N
T
I
L
A
--
Q
K
P
E
--
L
S
--
A
Q
L
T
A
I
G
H
R
I
V
H
G
G
E
K
Y
T
S
S
V
V
I
D
E
S
V
I
Q
G
I
K
D
S
A
S
F
A
P
L
H
N
P
A
H
L
I
G
I
A
E
A
L
K
S
F
P
Q
L
K
DK
N
V
A
V
F
D
T
A
F
H
Q
T
M
P
E
E
S
Y
L
Y
A
L
P
Y
S
L
Y
K
E
H
G
V
R
R
Y
G
A
H
G
T
S
H
F
Y
V
T
Q
E
A
A
K
M
L
N
K
P
V
E
E
L
N
I
I
T
C
H
L
G
N
G
G
S
V
S
A
I
R
N
G
K
C
V
D
T
S
M
G
L
T
P
L
E
G
L
V
M
G
T
R
S
G
D
I
D
P
A
I
I
F
H
L
H
D
T
L
G
M
S
V
D
Q
I
N
K
M
L
T
K
E
S
G
L
L
G
L
T
E
V-
T
-
S
D
C
R
Y
V
E
-
D
N
Y
A
T
K
E
D
A
K
R
A
M
D
V
Y
C
H
R
L
A
K
Y
I
G
S
Y
T
A
L
M
D
G
R
L
D
A
V
V
F
T
G
G
I
G
E
N
A
A
M
V
R
E
L
S
L
G
K
L
G
V
L
G
F
E
V
D
H
E
R
N
L
A
A
RFG
K
S
-
G
F
I
N
--
K
E
G
-
T
R
P
A
V
V
-
I
P
T
N
E
E
L
V
I
A
Q
D
A
S
R
L
T
A
-----
20
PsiBlast_PDB
83.13
39%
-89
- C5 -
4FWK
2
TDCD_SALTY
A:
[20-402]
--
V
L
V
I
N
C
G
S
S
S
I
K
F
S
V
L
D
V
A
T
C
D
V
L
M
A
G
I
A
D
G
M
N
T
E
N
A
F
L
--
S
I
N
G
DKPI
N
L
A
H
S
N
Y
E
D
A
L
K
------
A
I
A
F
E
L
E
K
R
D
L
T
------------
D
S
V
A
L
I
G
H
R
I
A
H
G
G
E
L
F
T
Q
S
V
I
I
T
D
E
I
I
D
N
I
R
R
V
S
P
L
A
P
L
H
N
Y
A
N
L
S
G
I
D
A
A
R
H
L
F
P
A
V
R
--
Q
V
A
V
F
D
T
S
F
H
Q
T
L
A
P
E
A
Y
L
Y
G
L
P
W
E
Y
F
S
S
L
G
V
R
R
Y
G
F
H
G
T
S
H
R
Y
V
S
R
R
A
Y
E
L
L
D
L
D
E
K
D
S
G
L
I
V
A
H
L
G
N
G
A
S
I
C
A
V
R
N
G
Q
S
V
D
T
S
M
G
M
T
P
L
E
G
L
M
M
G
T
R
S
G
D
V
D
F
G
A
M
A
W
I
A
K
E
T
G
Q
T
L
S
D
L
E
R
V
V
N
K
E
S
G
L
L
G
I
S
G
L-
S
-
S
D
L
R
V
L
E
K
A
W
H
E
G
H
E
R
A
R
L
A
I
K
T
F
V
H
R
I
A
R
H
I
A
G
H
A
A
S
L
H
-
R
L
D
G
I
I
F
T
G
G
I
G
E
N
S
V
L
I
R
Q
L
V
I
E
H
L
G
V
L
G
L
T
L
D
V
E
M
N
K
Q
P
---
N
S
-
H
G
E
R
I
I
S
A
N
P
S
Q
V
I
C
A
V
I
P
T
N
E
E
K
M
I
A
L
D
A
I
H
L
G
N
V
K
A
--
16
PsiBlast_PDB
83.05
39%
-88
- C5 -
1X3N
2
TDCD_SALTY
A:
[20-402]
--
V
L
V
I
N
C
G
S
S
S
I
K
F
S
V
L
D
V
A
T
C
D
V
L
M
A
G
I
A
D
G
M
N
T
E
N
A
F
L
--
S
I
N
G
DKPI
N
L
A
H
S
N
Y
E
D
A
L
K
------
A
I
A
F
E
L
E
K
R
D
L
T
------------
D
S
V
A
L
I
G
H
R
I
A
H
G
G
E
L
F
T
Q
S
V
I
I
T
D
E
I
I
D
N
I
R
R
V
S
P
L
A
P
L
H
N
Y
A
N
L
S
G
I
D
A
A
R
H
L
F
P
A
V
R
--
Q
V
A
V
F
D
T
S
F
H
Q
T
L
A
P
E
A
Y
L
Y
G
L
P
W
E
Y
F
S
S
L
G
V
R
R
Y
G
F
H
G
T
S
H
R
Y
V
S
R
R
A
Y
E
L
L
D
L
D
E
K
D
S
G
L
I
V
A
H
L
G
N
G
A
S
I
C
A
V
R
N
G
Q
S
V
D
T
S
M
G
M
T
P
L
E
G
L
M
M
G
T
R
S
G
D
V
D
F
G
A
M
A
W
I
A
K
E
T
G
Q
T
L
S
D
L
E
R
V
V
N
K
E
S
G
L
L
G
I
S
G
L-
S
-
S
D
L
R
V
L
E
K
A
W
H
E
G
H
E
R
A
R
L
A
I
K
T
F
V
H
R
I
A
R
H
I
A
G
H
A
A
S
L
H
-
R
L
D
G
I
I
F
T
G
G
I
G
E
N
S
V
L
I
R
Q
L
V
I
E
H
L
G
V
L
G
L
T
L
D
V
E
M
N
K
Q
P
---
N
S
-
H
G
E
R
I
I
S
A
N
P
S
Q
V
I
C
A
V
I
P
T
N
E
E
K
M
I
A
L
D
A
I
H
L
G
N
V
K
A
--
13
PsiBlast_PDB
82.46
39%
-86
- C5 -
4FWL
2
TDCD_SALTY
A:
[20-402]
--
V
L
V
I
N
C
G
S
S
S
I
K
F
S
V
L
D
V
A
T
C
D
V
L
M
A
G
I
A
D
G
M
N
T
E
N
A
F
L
--
S
I
N
G
DKPI
N
---
S
N
Y
E
D
A
L
K
------
A
I
A
F
E
L
E
K
R
D
L
T
------------
D
S
V
A
L
I
G
H
R
I
A
H
G
G
E
L
F
T
Q
S
V
I
I
T
D
E
I
I
D
N
I
R
R
V
S
P
L
A
P
L
H
N
Y
A
N
L
S
G
I
D
A
A
R
H
L
F
P
A
V
R
--
Q
V
A
V
F
D
T
S
F
H
Q
T
L
A
P
E
A
Y
L
Y
G
L
P
W
E
Y
F
S
S
L
G
V
R
R
Y
G
F
H
G
T
S
H
R
Y
V
S
R
R
A
Y
E
L
L
D
L
D
E
K
D
S
G
L
I
V
A
H
L
G
N
G
A
S
I
C
A
V
R
N
G
Q
S
V
D
T
S
M
G
M
T
P
L
E
G
L
M
M
G
T
R
S
G
D
V
D
F
G
A
M
A
W
I
A
K
E
T
G
Q
T
L
S
D
L
E
R
V
V
N
K
E
S
G
L
L
G
I
S
G
L-
S
-
S
D
L
R
V
L
E
K
A
W
H
E
G
H
E
R
A
R
L
A
I
K
T
F
V
H
R
I
A
R
H
I
A
G
H
A
A
S
L
H
-
R
L
D
G
I
I
F
T
G
G
I
G
E
N
S
V
L
I
R
Q
L
V
I
E
H
L
G
V
L
G
L
T
L
D
V
E
M
N
K
Q
P
---
N
S
-
H
G
E
R
I
I
S
A
N
P
S
Q
V
I
C
A
V
I
P
T
N
E
E
K
M
I
A
L
D
A
I
H
L
G
N
V
K
A
--
18
PsiBlast_PDB
82.39
39%
-88
- C5 -
2E1Z
2
TDCD_SALTY
A:
[20-402]
--
V
L
V
I
N
C
G
S
S
S
I
K
F
S
V
L
D
V
A
T
C
D
V
L
M
A
G
I
A
D
G
M
N
T
E
N
A
F
L
--
S
I
N
G
DKP
I
N
L
A
H
S
N
Y
E
D
A
L
K
------
A
I
A
F
E
L
E
K
R
D
L
T
------------
D
S
V
A
L
I
G
H
R
I
A
H
G
G
E
L
F
T
Q
S
V
I
I
T
D
E
I
I
D
N
I
R
R
V
S
P
L
A
P
L
H
N
Y
A
N
L
S
G
I
D
A
A
R
H
L
F
P
A
V
R
--
Q
V
A
V
F
D
T
S
F
H
Q
T
L
A
P
E
A
Y
L
Y
G
L
P
W
E
Y
F
S
S
L
G
V
R
R
Y
G
F
H
G
T
S
H
R
Y
V
S
R
R
A
Y
E
L
L
D
L
D
E
K
D
S
G
L
I
V
A
H
L
G
N
G
A
S
I
C
A
V
R
N
G
Q
S
V
D
T
S
M
G
M
T
P
L
E
G
L
M
M
G
T
R
S
G
D
V
D
F
G
A
M
A
W
I
A
K
E
T
G
Q
T
L
S
D
L
E
R
V
V
N
K
E
S
G
L
L
G
I
S
G
L-
S
-
S
D
L
R
V
L
E
K
A
W
H
E
G
H
E
R
A
R
L
A
I
K
T
F
V
H
R
I
A
R
H
I
A
G
H
A
A
S
L
H
-
R
L
D
G
I
I
F
T
G
G
I
G
E
N
S
V
L
I
R
Q
L
V
I
E
H
L
G
V
L
G
L
T
L
D
V
E
M
N
K
Q
P
---
N
S
-
H
G
E
R
I
I
S
A
N
P
S
Q
V
I
C
A
V
I
P
T
N
E
E
K
M
I
A
L
D
A
I
H
L
G
N
V
K
A
--
32
PsiBlast_CBE
82.32
39%
-89
- C5 -
4FWP
3
TDCD_SALTY
A:
[20-402]
--
V
L
V
I
N
C
G
S
S
S
I
K
F
S
V
L
D
V
A
T
C
D
V
L
M
A
G
I
A
D
G
M
N
T
E
N
A
F
L
--
S
I
N
G
DKP
I
N
L
A
H
S
N
Y
E
D
A
L
K
------
A
I
A
F
E
L
E
K
R
D
L
T
------------
D
S
V
A
L
I
G
H
R
I
A
H
G
G
E
L
F
T
Q
S
V
I
I
T
D
E
I
I
D
N
I
R
R
V
S
P
L
A
P
L
H
N
Y
A
N
L
S
G
I
D
A
A
R
H
L
F
P
A
V
R
--
Q
V
A
V
F
D
T
S
F
H
Q
T
L
A
P
E
A
Y
L
Y
G
L
P
W
E
Y
F
S
S
L
G
V
R
R
Y
G
F
H
G
T
S
H
R
Y
V
S
R
R
A
Y
E
L
L
D
L
D
E
K
D
S
G
L
I
V
A
H
L
G
N
G
A
S
I
C
A
V
R
N
G
Q
S
V
D
T
S
M
G
M
T
P
L
E
G
L
M
M
G
T
R
S
G
D
V
D
F
G
A
M
A
W
I
A
K
E
T
G
Q
T
L
S
D
L
E
R
V
V
N
K
E
S
G
L
L
G
I
S
G
L-
S
-
S
D
L
R
V
L
E
K
A
W
H
E
G
H
E
R
A
R
L
A
I
K
T
F
V
H
R
I
A
R
H
I
A
G
H
A
A
S
L
H
-
R
L
D
G
I
I
F
T
G
G
I
G
E
N
S
V
L
I
R
Q
L
V
I
E
H
L
G
V
L
G
L
T
L
D
V
E
M
N
K
Q
P
---
N
S
-
H
G
E
R
I
I
S
A
N
P
S
Q
V
I
C
A
V
I
P
T
N
E
E
K
M
I
A
L
D
A
I
H
L
G
N
V
K
A
--
15
PsiBlast_PDB
82.32
39%
-87
- C5 -
1X3M
1
TDCD_SALTY
A:
[20-402]
--
V
L
V
I
N
C
G
S
S
S
I
K
F
S
V
L
D
V
A
T
C
D
V
L
M
A
G
I
A
D
G
M
N
T
E
N
A
F
L
--
S
I
N
G
DKPI
N
L
A
H
S
N
Y
E
D
A
L
K
------
A
I
A
F
E
L
E
K
R
D
L
T
------------
D
S
V
A
L
I
G
H
R
I
A
H
G
G
E
L
F
T
Q
S
V
I
I
T
D
E
I
I
D
N
I
R
R
V
S
P
L
A
P
L
H
N
Y
A
N
L
S
G
I
D
A
A
R
H
L
F
P
A
V
R
--
Q
V
A
V
F
D
T
S
F
H
Q
T
L
A
P
E
A
Y
L
Y
G
L
P
W
E
Y
F
S
S
L
G
V
R
R
Y
G
F
H
G
T
S
H
R
Y
V
S
R
R
A
Y
E
L
L
D
L
D
E
K
D
S
G
L
I
V
A
H
L
G
N
G
A
S
I
C
A
V
R
N
G
Q
S
V
D
T
S
M
G
M
T
P
L
E
G
L
M
M
G
T
R
S
G
D
V
D
F
G
A
M
A
W
I
A
K
E
T
G
Q
T
L
S
D
L
E
R
V
V
N
K
E
S
G
L
L
G
I
S
G
L-
S
-
S
D
L
R
V
L
E
K
A
W
H
E
G
H
E
R
A
R
L
A
I
K
T
F
V
H
R
I
A
R
H
I
A
G
H
A
A
S
L
H
-
R
L
D
G
I
I
F
T
G
G
I
G
E
N
S
V
L
I
R
Q
L
V
I
E
H
L
G
V
L
G
L
T
L
D
V
E
M
N
K
Q
P
---
N
S
-
H
G
E
R
I
I
S
A
N
P
S
Q
V
I
C
A
V
I
P
T
N
E
E
K
M
I
A
L
D
A
I
H
L
G
N
V
K
A
--
19
PsiBlast_PDB
82.28
39%
-89
- C5 -
2E20
2
TDCD_SALTY
A:
[20-402]
--
V
L
V
I
N
C
G
S
S
S
I
K
F
S
V
L
D
V
A
T
C
D
V
L
M
A
G
I
A
D
G
M
N
T
E
N
A
F
L
--
S
I
N
G
DKPI
N
L
A
H
S
N
Y
E
D
A
L
K
------
A
I
A
F
E
L
E
K
R
D
L
T
------------
D
S
V
A
L
I
G
H
R
I
A
H
G
G
E
L
F
T
Q
S
V
I
I
T
D
E
I
I
D
N
I
R
R
V
S
P
L
A
P
L
H
N
Y
A
N
L
S
G
I
D
A
A
R
H
L
F
P
A
V
R
--
Q
V
A
V
F
D
T
S
F
H
Q
T
L
A
P
E
A
Y
L
Y
G
L
P
W
E
Y
F
S
S
L
G
V
R
R
Y
G
F
H
G
T
S
H
R
Y
V
S
R
R
A
Y
E
L
L
D
L
D
E
K
D
S
G
L
I
V
A
H
L
G
N
G
A
S
I
C
A
V
R
N
G
Q
S
V
D
T
S
M
G
M
T
P
L
E
G
L
M
M
G
T
R
S
G
D
V
D
F
G
A
M
A
W
I
A
K
E
T
G
Q
T
L
S
D
L
E
R
V
V
N
K
E
S
G
L
L
G
I
S
G
L-
S
-
S
D
L
R
V
L
E
K
A
W
H
E
G
H
E
R
A
R
L
A
I
K
T
F
V
H
R
I
A
R
H
I
A
G
H
A
A
S
L
H
-
R
L
D
G
I
I
F
T
G
G
I
G
E
N
S
V
L
I
R
Q
L
V
I
E
H
L
G
V
L
G
L
T
L
D
V
E
M
N
K
Q
P
---
N
S
-
H
G
E
R
I
I
S
A
N
P
S
Q
V
I
C
A
V
I
P
T
N
E
E
K
M
I
A
L
D
A
I
H
L
G
N
V
K
A
--
29
PsiBlast_CBE
82.16
39%
-85
- C5 -
4FWS
5
TDCD_SALTY
A:
[20-402]
--
V
L
V
I
N
C
G
S
S
S
I
K
F
S
V
L
D
V
A
T
C
D
V
L
M
A
G
I
A
D
G
M
N
T
E
N
A
F
L
--
S
I
N
G
D
K
P
I
N
L
A
H
S
N
Y
E
D
A
L
K
------
A
I
A
F
E
L
E
K
R
D
L
T
------------
D
S
V
A
L
I
G
H
R
I
A
H
G
G
E
L
F
T
Q
S
V
I
I
T
D
E
I
I
D
N
I
R
R
V
S
P
L
A
P
L
H
N
Y
A
N
L
S
G
I
D
A
A
R
H
L
F
P
A
V
R
--
Q
V
A
V
F
D
T
S
F
H
Q
T
L
A
P
E
A
Y
L
Y
G
L
P
W
E
Y
F
S
S
L
G
V
R
R
Y
G
F
H
G
T
S
H
R
Y
V
S
R
R
A
Y
E
L
L
D
L
D
E
K
D
S
G
L
I
V
A
H
L
G
N
G
A
S
I
C
A
V
R
N
G
Q
S
V
D
T
S
M
G
M
T
P
L
E
G
L
M
M
G
T
R
S
G
D
V
D
F
G
A
M
A
W
I
A
K
E
T
G
Q
T
L
S
D
L
E
R
V
V
N
K
E
S
G
L
L
G
I
S
G
L-
S
-
S
D
L
R
V
L
E
K
A
W
H
E
G
H
E
R
A
R
L
A
I
K
T
F
V
H
R
I
A
R
H
I
A
G
H
A
A
S
L
H
-
R
L
D
G
I
I
F
T
G
G
I
G
E
N
S
V
L
I
R
Q
L
V
I
E
H
L
G
V
L
G
L
T
L
D
V
E
M
N
K
Q
P
---
N
S
-
H
G
E
R
I
I
S
A
N
P
S
Q
V
I
C
A
V
I
P
T
N
E
E
K
M
I
A
L
D
A
I
H
L
G
N
V
K
A
--
30
PsiBlast_CBE
82.04
39%
-87
- C5 -
4FWR
3
TDCD_SALTY
A:
[20-402]
--
V
L
V
I
N
C
G
S
S
S
I
K
F
S
V
L
D
V
A
T
C
D
V
L
M
A
G
I
A
D
G
M
N
T
E
N
A
F
L
--
S
I
N
G
DKPI
N
L
A
H
S
N
Y
E
D
A
L
K
------
A
I
A
F
E
L
E
K
R
D
L
T
------------
D
S
V
A
L
I
G
H
R
I
A
H
G
G
E
L
F
T
Q
S
V
I
I
T
D
E
I
I
D
N
I
R
R
V
S
P
L
A
P
L
H
N
Y
A
N
L
S
G
I
D
A
A
R
H
L
F
P
A
V
R
--
Q
V
A
V
F
D
T
S
F
H
Q
T
L
A
P
E
A
Y
L
Y
G
L
P
W
E
Y
F
S
S
L
G
V
R
R
Y
G
F
H
G
T
S
H
R
Y
V
S
R
R
A
Y
E
L
L
D
L
D
E
K
D
S
G
L
I
V
A
H
L
G
N
G
A
S
I
C
A
V
R
N
G
Q
S
V
D
T
S
M
G
M
T
P
L
E
G
L
M
M
G
T
R
S
G
D
V
D
F
G
A
M
A
W
I
A
K
E
T
G
Q
T
L
S
D
L
E
R
V
V
N
K
E
S
G
L
L
G
I
S
G
L-
S
-
S
D
L
R
V
L
E
K
A
W
H
E
G
H
E
R
A
R
L
A
I
K
T
F
V
H
R
I
A
R
H
I
A
G
H
A
A
S
L
H
-
R
L
D
G
I
I
F
T
G
G
I
G
E
N
S
V
L
I
R
Q
L
V
I
E
H
L
G
V
L
G
L
T
L
D
V
E
M
N
K
Q
P
---
N
S
-
H
G
E
R
I
I
S
A
N
P
S
Q
V
I
C
A
V
I
P
T
N
E
E
K
M
I
A
L
D
A
I
H
L
G
N
V
K
A
--
33
PsiBlast_CBE
82.01
39%
-90
- C5 -
4FWO
4
TDCD_SALTY
A:
[20-402]
--
V
L
V
I
N
C
G
S
S
S
I
K
F
S
V
L
D
V
A
T
C
D
V
L
M
A
G
I
A
D
G
M
N
T
E
N
A
F
L
--
S
I
N
G
DKPI
N
L
A
H
S
N
Y
E
D
A
L
K
------
A
I
A
F
E
L
E
K
R
D
L
T
------------
D
S
V
A
L
I
G
H
R
I
A
H
G
G
E
L
F
T
Q
S
V
I
I
T
D
E
I
I
D
N
I
R
R
V
S
P
L
A
P
L
H
N
Y
A
N
L
S
G
I
D
A
A
R
H
L
F
P
A
V
R
--
Q
V
A
V
F
D
T
S
F
H
Q
T
L
A
P
E
A
Y
L
Y
G
L
P
W
E
Y
F
S
S
L
G
V
R
R
Y
G
F
H
G
T
S
H
R
Y
V
S
R
R
A
Y
E
L
L
D
L
D
E
K
D
S
G
L
I
V
A
H
L
G
N
G
A
S
I
C
A
V
R
N
G
Q
S
V
D
T
S
M
G
M
T
P
L
E
G
L
M
M
G
T
R
S
G
D
V
D
F
G
A
M
A
W
I
A
K
E
T
G
Q
T
L
S
D
L
E
R
V
V
N
K
E
S
G
L
L
G
I
S
G
L-
S
-
S
D
L
R
V
L
E
K
A
W
H
E
G
H
E
R
A
R
L
A
I
K
T
F
V
H
R
I
A
R
H
I
A
G
H
A
A
S
L
H
-
R
L
D
G
I
I
F
T
G
G
I
G
E
N
S
V
L
I
R
Q
L
V
I
E
H
L
G
V
L
G
L
T
L
D
V
E
M
N
K
Q
P
---
N
S
-
H
G
E
R
I
I
S
A
N
P
S
Q
V
I
C
A
V
I
P
T
N
E
E
K
M
I
A
L
D
A
I
H
L
G
N
V
K
A
--
14
PsiBlast_PDB
81.56
39%
-88
- C5 -
4FWM
4
TDCD_SALTY
A:
[20-402]
--
V
L
V
I
N
C
G
S
S
S
I
K
F
S
V
L
D
V
A
T
C
D
V
L
M
A
G
I
A
D
G
M
N
T
E
N
A
F
L
--
S
I
N
G
DKPI
N
L
A
H
S
N
Y
E
D
A
L
K
------
A
I
A
F
E
L
E
K
R
D
L
T
------------
D
S
V
A
L
I
G
H
R
I
A
H
G
G
E
L
F
T
Q
S
V
I
I
T
D
E
I
I
D
N
I
R
R
V
S
P
L
A
P
L
H
N
Y
A
N
L
S
G
I
D
A
A
R
H
L
F
P
A
V
R
--
Q
V
A
V
F
D
T
S
F
H
Q
T
L
A
P
E
A
Y
L
Y
G
L
P
W
E
Y
F
S
S
L
G
V
R
R
Y
G
F
H
G
T
S
H
R
Y
V
S
R
R
A
Y
E
L
L
D
L
D
E
K
D
S
G
L
I
V
A
H
L
G
N
G
A
S
I
C
A
V
R
N
G
Q
S
V
D
T
S
M
G
M
T
P
L
E
G
L
M
M
G
T
R
S
G
D
V
D
F
G
A
M
A
W
I
A
K
E
T
G
Q
T
L
S
D
L
E
R
V
V
N
K
E
S
G
L
L
G
I
S
G
L-
S
-
S
D
L
R
V
L
E
K
A
W
H
E
G
H
E
R
A
R
L
A
I
K
T
F
V
H
R
I
A
R
H
I
A
G
H
A
A
S
L
H
-
R
L
D
G
I
I
F
T
G
G
I
G
E
N
S
V
L
I
R
Q
L
V
I
E
H
L
G
V
L
G
L
T
L
D
V
E
M
N
K
Q
P
---
N
S
-
H
G
E
R
I
I
S
A
N
P
S
Q
V
I
C
A
V
I
P
T
N
E
E
K
M
I
A
L
D
A
I
H
L
G
N
V
K
A
--
34
PsiBlast_CBE
81.38
39%
-85
- C5 -
4FWN
3
TDCD_SALTY
A:
[20-402]
--
V
L
V
I
N
C
G
S
S
S
I
K
F
S
V
L
D
V
A
T
C
D
V
L
M
A
G
I
A
D
G
M
N
T
E
N
A
F
L
--
S
I
N
G
DKPI
N
L
A
H
S
N
Y
E
D
A
L
K
------
A
I
A
F
E
L
E
K
R
D
L
T
------------
D
S
V
A
L
I
G
H
R
I
A
H
G
G
E
L
F
T
Q
S
V
I
I
T
D
E
I
I
D
N
I
R
R
V
S
P
L
A
P
L
H
N
Y
A
N
L
S
G
I
D
A
A
R
H
L
F
P
A
V
R
--
Q
V
A
V
F
D
T
S
F
H
Q
T
L
A
P
E
A
Y
L
Y
G
L
P
W
E
Y
F
S
S
L
G
V
R
R
Y
G
F
H
G
T
S
H
R
Y
V
S
R
R
A
Y
E
L
L
D
L
D
E
K
D
S
G
L
I
V
A
H
L
G
N
G
A
S
I
C
A
V
R
N
G
Q
S
V
D
T
S
M
G
M
T
P
L
E
G
L
M
M
G
T
R
S
G
D
V
D
F
G
A
M
A
W
I
A
K
E
T
G
Q
T
L
S
D
L
E
R
V
V
N
K
E
S
G
L
L
G
I
S
G
L-
S
-
S
D
L
R
V
L
E
K
A
W
H
E
G
H
E
R
A
R
L
A
I
K
T
F
V
H
R
I
A
R
H
I
A
G
H
A
A
S
L
H
-
R
L
D
G
I
I
F
T
G
G
I
G
E
N
S
V
L
I
R
Q
L
V
I
E
H
L
G
V
L
G
L
T
L
D
V
E
M
N
K
Q
P
---
N
S
-
H
G
E
R
I
I
S
A
N
P
S
Q
V
I
C
A
V
I
P
T
N
E
E
K
M
I
A
L
D
A
I
H
L
G
N
V
K
A
--
31
PsiBlast_CBE
81.18
39%
-85
- C5 -
4FWQ
3
TDCD_SALTY
A:
[20-402]
--
V
L
V
I
N
C
G
S
S
S
I
K
F
S
V
L
D
V
A
T
C
D
V
L
M
A
G
I
A
D
G
M
N
T
E
N
A
F
L
--
S
I
N
G
D
K
P
I
N
L
A
H
S
N
Y
E
D
A
L
K
------
A
I
A
F
E
L
E
K
R
D
L
T
------------
D
S
V
A
L
I
G
H
R
I
A
H
G
G
E
L
F
T
Q
S
V
I
I
T
D
E
I
I
D
N
I
R
R
V
S
P
L
A
P
L
H
N
Y
A
N
L
S
G
I
D
A
A
R
H
L
F
P
A
V
R
--
Q
V
A
V
F
D
T
S
F
H
Q
T
L
A
P
E
A
Y
L
Y
G
L
P
W
E
Y
F
S
S
L
G
V
R
R
Y
G
F
H
G
T
S
H
R
Y
V
S
R
R
A
Y
E
L
L
D
L
D
E
K
D
S
G
L
I
V
A
H
L
G
N
G
A
S
I
C
A
V
R
N
G
Q
S
V
D
T
S
M
G
M
T
P
L
E
G
L
M
M
G
T
R
S
G
D
V
D
F
G
A
M
A
W
I
A
K
E
T
G
Q
T
L
S
D
L
E
R
V
V
N
K
E
S
G
L
L
G
I
S
G
L-
S
-
S
D
L
R
V
L
E
K
A
W
H
E
G
H
E
R
A
R
L
A
I
K
T
F
V
H
R
I
A
R
H
I
A
G
H
A
A
S
L
H
-
R
L
D
G
I
I
F
T
G
G
I
G
E
N
S
V
L
I
R
Q
L
V
I
E
H
L
G
V
L
G
L
T
L
D
V
E
M
N
K
Q
P
---
N
S
-
H
G
E
R
I
I
S
A
N
P
S
Q
V
I
C
A
V
I
P
T
N
E
E
K
M
I
A
L
D
A
I
H
L
G
N
V
K
A
--