@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_0855: (2015-12-18 )
MKIFINGFGRIGRCVLRAILERNDTNPQLEVIGINDPANWEILAYLLEHDSTHGLLNKEVRYSNGKLIIGSLEIPVFNSIKDLKGVGVIIECSGKFLEPKTLENYLLLGAKKVLLSAPFMGEYDEKQYPTLVYGVNHFLYQNQAIVSNASCTTNAIAPICAILDKAFSIKEGMLTTIHSYTSDQKLIDLAHPLDKRRSRAAASNIIPTTTKAALALHKVLPNLKNKMHGHSVRVPSLDVSMIDLSLFLEKKALKDPINDLLITASKGTLKGVLEIDLKERVSSDFISNPNSVIIAPDLTFTLENMVKIMGWYDNEWGYSNRLVDMAQFMYHY
Atome Classification :
(46 SA)
.........10........20......---..30......-.-.40........50.....-------..-.60..-......70.....------..--.-------80---.------.----..-------.....90........100.......110.......120.......130.....-..140.--.--..--.....150.......160.......170.......180.......190--.......200.......210.......220.......230.......240.......250........260....-------...270.......280.......290.......300-.-.-.....310.......320.......330
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
K
I
F
INGF
G
R
I
G
R
C
V
L
R
A
I
L
ERNDTNP---
Q
L
E
V
I
GINDP-A-
N
W
E
I
L
A
Y
L
L
EHDSTHGLL-------N
K
-
E
V
RYS-NG
K
L
I
I
G
SLEIP
V
------
F
N
--
S
-------
I
----
K
------D----LK-------G
V
G
V
I
I
ECSGKFL
E
P
K
T
L
E
N
Y
L
L
L
G
A
K
K
V
L
LSAPFMGEYDEKQY
P
T
L
V
Y
G
V
N
H
-
F
L
Y--Q--N--
Q
A
--
I
VSNASCTT
N
A
I
A
P
I
C
A
I
L
D
K
A
F
S
I
K
E
G
M
L
T
T
I
H
SYTSD
Q
K
L
I
D
LAH
P
--
L
D
K
R
R
S
RAAASNIIPT
T
T
K
A
A
L
A
L
H
K
V
L
P
N
L
K
N
KMHGHSVRVPSL
D
V
S
M
I
D
L
S
L
F
L
E
K
K
-
A
L
KDP
I
N
D
L
L
I
TASK-------GT
L
K
G
V
L
E
I
D
L
K
E
R
V
S
S
DFISNP
N
S
V
I
IAPD
L
T
F
T
L
-
E
-
N
-
M
V
K
I
M
GWYDNEWGYSN
R
L
V
D
M
A
Q
F
M
YHY
115
HHSearch
94.17
42%
-110
- C4 -
1RM4
3
G3PA_SPIOL
O:
[2-334]
L
K
V
A
I
N
G
F
G
R
I
G
R
N
F
L
R
C
W
H
G
----
R
K
DS-
P
L
D
V
V
V
I
N
D
T
-
G
-
G
V
K
Q
A
S
H
L
L
K
Y
D
S
I
L
G
T
F
-------
D
A
-
D
V
K
T
A
G
D
S
A
I
S
V
D
G
K
V
I
K
V
------
V
S
--
D
RN-----
P
----
V
------
N
LPWG
D
M
-------
G
I
D
L
V
I
E
G
T
G
V
F
V
D
R
D
G
A
G
K
H
L
Q
A
G
A
K
K
V
L
I
T
A
P
G
K
G
-----
D
I
P
T
Y
V
V
G
V
N
E
-
E
G
Y
--
T
H-
A
--
D
T
--
I
I
S
N
A
S
C
T
T
N
C
L
A
P
F
V
K
V
L
D
Q
K
F
G
I
I
K
G
T
M
T
T
T
H
S
Y
T
G
D
Q
R
L
L
D
A
S
H
---
R
D
L
R
R
A
R
A
A
C
L
N
I
V
P
T
S
T
G
A
A
K
A
V
A
L
V
L
P
N
L
K
G
K
L
N
G
I
A
L
R
V
P
T
P
N
V
S
V
V
D
L
V
V
Q
V
S
K
K
-
T
F
A
E
E
V
N
A
A
F
R
E
S
A
D
-------
N
E
L
K
G
I
L
S
V
C
D
E
P
L
V
S
I
D
F
R
C
T
D
V
S
S
T
I
D
S
S
L
T
M
V
M
-
G
D
D
-
M
V
K
V
I
A
W
Y
D
N
E
W
G
Y
S
Q
R
V
V
D
L
A
D
I
V
A
N
K
114
HHSearch
93.70
43%
-112
- C4 -
2B4R
4
?
O:
[12-344]
T
K
L
G
I
N
G
F
G
R
I
G
R
L
V
F
R
A
A
F
G
----
R
K
---
D
I
E
V
V
A
I
N
D
P
F
M
-
D
L
N
H
L
C
Y
L
L
K
Y
D
S
V
H
G
Q
F
-------
P
C
-
E
V
T
H
A
-
D
G
F
L
L
I
G
E
K
K
V
S
V
------
F
A
--
E
KD-----
P
----
S
------
Q
IPWG
K
C
-------
Q
V
D
V
V
C
E
S
T
G
V
F
L
T
K
E
L
A
S
S
H
L
K
G
G
A
K
K
V
I
M
S
A
P
P
K
D
-----
D
T
P
I
Y
V
M
G
I
N
H
-
H
Q
Y
--
D
T-
K
--
Q
L
--
I
V
S
N
A
S
C
T
T
N
C
L
A
P
L
A
K
V
I
N
D
R
F
G
I
V
E
G
L
M
T
T
V
H
A
S
T
A
N
Q
L
V
V
D
G
P
S
K
GG
K
D
W
R
A
G
R
C
A
L
S
N
I
I
P
A
S
T
G
A
A
K
A
V
G
K
V
L
P
E
L
N
G
K
L
T
G
V
A
F
R
V
P
I
G
T
V
S
V
V
D
L
V
C
R
L
Q
K
P
-
A
K
Y
E
E
V
A
L
E
I
K
K
A
A
E
-------
G
P
L
K
G
I
L
G
Y
T
E
D
E
V
V
S
Q
D
F
V
H
D
N
R
S
S
I
F
D
M
K
A
G
L
A
L
-
N
D
N
-
F
F
K
L
V
S
W
Y
D
N
E
W
G
Y
S
N
R
V
L
D
L
A
V
H
I
T
T
-
66
PsiBlast_CBE
93.28
41%
-117
- C4 -
2I5P
2
G3P1_KLUMA
P:
[15-339]
V
S
I
A
I
N
G
F
G
R
I
G
R
L
V
L
R
I
A
L
E
R
K
N
-------
I
D
V
V
A
I
N
D
P
F
I
-
S
V
D
Y
A
A
Y
M
F
K
Y
D
S
T
H
G
K
Y
-------
K
G
-
E
V
S
H
D
-
G
S
N
L
I
I
N
G
K
K
V
A
V
------
F
Q
--
E
------------
K
------
D
----
P
A
TLPWGKL
G
V
D
I
A
V
D
S
T
G
V
F
K
E
L
D
S
A
Q
K
H
I
D
A
G
A
K
K
V
V
I
T
A
P
------
S
K
T
A
P
M
F
V
V
G
V
N
E
-
D
K
Y
--
N
--
G
--
E
K
--
I
V
S
N
A
S
C
T
T
N
C
L
A
P
I
A
K
I
I
N
D
E
F
G
I
E
E
G
L
M
T
T
V
H
S
I
T
----------------------
S
G
N
I
I
P
S
S
T
G
A
A
K
A
V
G
K
V
L
P
E
L
Q
G
K
L
T
G
M
A
F
R
V
P
T
T
D
V
S
V
V
D
L
T
V
K
L
V
K
A
-
A
T
Y
D
E
I
K
A
A
V
K
K
V
S
E
-------
G
K
L
K
D
V
V
G
Y
T
E
D
A
V
V
S
S
D
F
L
G
D
T
H
S
T
I
F
D
A
A
A
G
I
Q
L
-
S
P
K
-
F
V
K
L
V
A
W
Y
D
N
E
Y
G
Y
S
T
R
V
V
D
L
V
E
H
V
A
--
17
PsiBlast_PDB
93.02
41%
-116
- C4 -
2I5P
2
G3P1_KLULA (first)
O:
[15-339]
V
S
I
A
I
N
G
F
G
R
I
G
R
L
V
L
R
I
A
L
E
R
K
N
-------
I
D
V
V
A
I
N
D
P
F
I
-
S
V
D
Y
A
A
Y
M
F
K
Y
D
S
T
H
G
K
Y
-------
K
G
-
E
V
S
H
D
-
G
S
N
L
I
I
N
G
K
K
V
A
V
------
F
Q
--
E
------------
K
------
D
----
P
A
TLPWGKL
G
V
D
I
A
V
D
S
T
G
V
F
K
E
L
D
S
A
Q
K
H
I
D
A
G
A
K
K
V
V
I
T
A
P
------
S
K
T
A
P
M
F
V
V
G
V
N
E
-
D
K
Y
--
N
--
G
--
E
K
--
I
V
S
N
A
S
C
T
T
N
C
L
A
P
I
A
K
I
I
N
D
E
F
G
I
E
E
G
L
M
T
T
V
H
S
I
T
----------------------
S
G
N
I
I
P
S
S
T
G
A
A
K
A
V
G
K
V
L
P
E
L
Q
G
K
L
T
G
M
A
F
R
V
P
T
T
D
V
S
V
V
D
L
T
V
K
L
V
K
A
-
A
T
Y
D
E
I
K
A
A
V
K
K
V
S
E
-------
G
K
L
K
D
V
V
G
Y
T
E
D
A
V
V
S
S
D
F
L
G
D
T
H
S
T
I
F
D
A
A
A
G
I
Q
L
-
S
P
K
-
F
V
K
L
V
A
W
Y
D
N
E
Y
G
Y
S
T
R
V
V
D
L
V
E
H
V
A
--
128
HHSearch
92.60
41%
-113
- C4 -
3V1Y
2
G3PC1_ORYSJ
O:
[4-335]
I
K
I
G
I
N
G
F
G
R
I
G
R
L
V
A
R
V
A
L
Q
----
S
E
---
D
V
E
L
V
A
V
N
D
P
-
F
I
T
T
D
Y
M
T
Y
M
F
K
Y
D
T
V
H
G
Q
W
-------
K
H
S
D
I
K
I
K
D
S
K
T
L
L
L
G
E
K
P
V
T
V
------
F
G
--
I
RN-----
P
----
D
------
E
IPWA
E
A
-------
G
A
E
Y
V
V
E
S
T
G
V
F
T
D
K
E
K
A
A
A
H
L
K
G
G
A
K
K
V
V
I
S
A
P
S
K
D
------
A
P
M
F
V
C
G
V
N
E
-
D
K
Y
--
T
S-
D
--
I
D
--
I
V
S
N
A
S
C
T
T
N
C
L
A
P
L
A
K
V
I
H
D
N
F
G
I
I
E
G
L
M
T
T
V
H
A
I
T
A
T
Q
K
T
V
D
G
P
S
S
--
K
D
W
R
G
G
R
A
A
S
F
N
I
I
P
S
S
T
G
A
A
K
A
V
G
K
V
L
P
D
L
N
G
K
L
T
G
M
S
F
R
V
P
T
V
D
V
S
V
V
D
L
T
V
R
I
E
K
A
-
A
S
Y
D
A
I
K
S
A
I
K
S
A
S
E
-------
G
K
L
K
G
I
I
G
Y
V
E
E
D
L
V
S
T
D
F
V
G
D
S
R
S
S
I
F
D
A
K
A
G
I
A
L
-
N
D
N
-
F
V
K
L
V
A
W
Y
D
N
E
W
G
Y
S
N
R
V
I
D
L
I
R
H
M
A
K
T
117
HHSearch
92.27
39%
-119
- C4 -
2X5J
1
E4PD_ECOLI
O:
[3-336]
V
R
V
A
I
N
G
F
G
R
I
G
R
N
V
V
R
A
L
Y
E
----
S
G
RRA
E
I
T
V
V
A
I
N
E
L
-
A
-
D
A
A
G
M
A
H
L
L
K
Y
D
T
S
H
G
R
F
-------
A
W
-
E
V
R
Q
E
-
R
D
Q
L
F
V
G
D
D
A
I
R
V
------
L
H
ER
S
-------
L
----
Q
------
S
LPWR
E
L
-------
G
V
D
V
V
L
D
C
T
G
V
Y
G
S
R
E
H
G
E
A
H
I
A
A
G
A
K
K
V
L
F
S
H
P
G
S
N
D
----
L
D
A
T
V
V
Y
G
V
N
Q
-
D
Q
L
--
R
A-
E
--
H
R
--
I
V
S
N
A
S
C
T
T
N
C
I
I
P
V
I
K
L
L
D
D
A
Y
G
I
E
S
G
T
V
T
T
I
H
S
A
M
--------------
D
L
R
R
T
R
A
A
S
Q
S
I
I
P
V
D
T
K
L
A
A
G
I
T
R
F
F
P
Q
F
N
D
R
F
E
A
I
A
V
R
V
P
T
I
N
V
T
A
I
D
L
S
V
T
V
K
K
P
-
V
K
A
N
E
V
N
L
L
L
Q
K
A
A
Q
-------
G
A
F
H
G
I
V
D
Y
T
E
L
P
L
V
S
V
D
F
N
H
D
P
H
S
A
I
V
D
G
T
Q
T
R
V
S
-
G
A
H
-
L
I
K
T
L
V
W
C
D
N
E
W
G
F
A
N
R
M
L
D
T
T
L
A
M
A
T
V
122
HHSearch
92.25
41%
-114
- C4 -
3PYM
3
G3P3_YEAST
A:
[2-331]
V
R
V
A
I
N
G
F
G
R
I
G
R
L
V
M
R
I
A
L
S
----
R
P
---
N
V
E
V
V
A
L
N
D
P
F
I
-
T
N
D
Y
A
A
Y
M
F
K
Y
D
S
T
H
G
R
Y
-------
A
G
-
E
V
S
H
D
-
D
K
H
I
I
V
D
G
K
K
I
A
T
------
Y
Q
--
E
RD-----
P
ANLP
W
------
G
----
S
S
-------
N
V
D
I
A
I
D
S
T
G
V
F
K
E
L
D
T
A
Q
K
H
I
D
A
G
A
K
K
V
V
I
T
A
P
S
S
T
------
A
P
M
F
V
M
G
V
N
E
-
E
K
Y
--
T
S-
D
--
L
K
--
I
V
S
N
A
S
C
T
T
N
C
L
A
P
L
A
K
V
I
N
D
A
F
G
I
E
E
G
L
M
T
T
V
H
S
L
T
A
T
Q
K
T
V
D
G
P
S
H
--
K
D
W
R
G
G
R
T
A
S
G
N
I
I
P
S
S
T
G
A
A
K
A
V
G
K
V
L
P
E
L
Q
G
K
L
T
G
M
A
F
R
V
P
T
V
D
V
S
V
V
D
L
T
V
K
L
N
K
E
-
T
T
Y
D
E
I
K
K
V
V
K
A
A
A
E
-------
G
K
L
K
G
V
L
G
Y
T
E
D
A
V
V
S
S
D
F
L
G
D
S
H
S
S
I
F
D
A
S
A
G
I
Q
L
-
S
P
K
-
F
V
K
L
V
S
W
Y
D
N
E
Y
G
Y
S
T
R
V
V
D
L
V
E
H
V
A
K
A
120
HHSearch
92.06
42%
-114
- C4 -
3CPS
1
?
A:
[18-352]
G
T
L
G
I
N
G
F
G
R
I
G
R
L
V
L
R
A
C
M
E
----
R
N
---
D
I
T
V
V
A
I
N
D
P
F
M
-
D
V
E
Y
M
A
Y
L
L
K
Y
D
S
V
H
G
N
F
-------
N
G
-
T
V
E
V
S
-
G
-
D
L
C
I
N
G
K
V
V
K
V
------
F
Q
--
A
KD-----
P
----
A
------
E
IPWG
A
S
-------
G
A
Q
I
V
C
E
S
T
G
V
F
T
T
E
E
K
A
S
L
H
L
K
G
G
A
K
K
V
I
I
S
A
P
P
K
D
-----
N
V
P
M
Y
V
M
G
V
N
N
-
T
E
Y
--
D
PS
K
--
F
N
--
V
I
S
N
A
S
C
T
T
N
C
L
A
P
L
A
K
I
I
N
D
K
F
G
I
V
E
G
L
M
T
T
V
H
S
L
T
A
N
Q
L
T
V
D
G
P
S
K
G--
D
W
R
A
G
R
C
A
G
N
N
I
I
P
A
S
T
G
A
A
K
A
V
G
K
V
I
P
A
L
N
G
K
L
T
G
M
A
I
R
V
P
T
P
D
V
S
V
V
D
L
T
C
K
L
A
K
P
-
A
S
I
E
E
I
Y
Q
A
V
K
E
A
S
N
-------
G
P
M
K
G
I
M
G
Y
T
S
D
D
V
V
S
T
D
F
I
G
C
K
Y
S
S
I
F
D
K
N
A
C
I
A
L
-
N
D
S
-
F
V
K
L
I
S
W
Y
D
N
E
S
G
Y
S
N
R
L
V
D
L
A
V
Y
V
A
S
R
126
HHSearch
92.02
41%
-111
- C4 -
3H9E
10
G3PT_HUMAN
O:
[8-337]
L
T
V
G
I
N
G
F
G
R
I
G
R
L
V
L
R
A
C
M
E
----
K
----
G
V
K
V
V
A
V
N
D
P
F
I
-
D
P
E
Y
M
V
Y
M
F
K
Y
D
S
T
H
G
R
Y
-------
K
G
-
S
V
E
F
R
-
N
G
Q
L
V
V
D
N
H
E
I
S
V
------
Y
Q
--
C
KE-----
P
----
K
------
Q
IPWR
A
V
-------
G
S
P
Y
V
V
E
S
T
G
V
Y
L
S
I
Q
A
A
S
D
H
I
S
A
G
A
Q
R
V
V
I
S
A
P
S
P
------
D
A
P
M
F
V
M
G
V
N
E
-
N
D
Y
--
N
--
P
GS
M
N
--
I
V
S
N
A
S
C
T
T
N
C
L
A
P
L
A
K
V
I
H
E
R
F
G
I
V
E
G
L
M
T
T
V
H
S
Y
T
A
T
Q
K
T
V
D
G
P
S
R
--
K
A
W
R
D
G
R
G
A
H
Q
N
I
I
P
A
S
T
G
A
A
K
A
V
T
K
V
I
P
E
L
K
G
K
L
T
G
M
A
F
R
V
P
T
P
D
V
S
V
V
D
L
T
C
R
L
A
Q
P
-
A
P
Y
S
A
I
K
E
A
V
K
A
A
A
K
-------
G
P
M
A
G
I
L
A
Y
T
E
D
E
V
V
S
T
D
F
L
G
D
T
H
S
S
I
F
D
A
K
A
G
I
A
L
-
N
D
N
-
F
V
K
L
I
S
W
Y
D
N
E
Y
G
Y
S
H
R
V
V
D
L
L
R
Y
M
F
S
R
61
PsiBlast_CBE
91.84
42%
-113
- C4 -
1CER
2
G3P_THEAQ
D:
[1-326]
M
K
V
G
I
N
G
F
G
R
I
G
R
Q
V
F
R
I
L
H
S
R
G
--------
V
E
V
A
L
I
N
D
L
-
T
-
D
N
K
T
L
A
H
L
L
K
Y
D
S
I
Y
H
R
F
-------
P
G
-
E
V
A
Y
D
-
D
Q
Y
L
Y
V
D
G
K
A
I
R
A
-------
T
--
A
-------
V
----
K
------
D
----
P
K
EIPWAEA
G
V
G
V
V
I
E
S
T
G
V
F
T
D
A
D
K
A
K
A
H
L
E
G
G
A
K
K
V
I
I
T
A
P
A
K
G
E
D
-----
I
T
I
V
M
G
V
N
H
-
E
A
Y
DP
S
--
R
--
H
H
--
I
I
S
N
A
S
C
T
T
N
S
L
A
P
V
M
K
V
L
E
E
A
F
G
V
E
K
A
L
M
T
T
V
H
S
Y
T
N
D
Q
R
L
L
D
L
P
H
K
---
D
L
R
R
A
R
A
A
A
I
N
I
I
P
T
T
T
G
A
A
K
A
T
A
L
V
L
P
S
L
K
G
R
F
D
G
M
A
L
R
V
P
T
A
T
G
S
I
S
D
I
T
A
L
L
K
R
E
-
V
T
A
E
E
V
N
A
A
L
K
A
A
A
E
-------
G
P
L
K
G
I
L
A
Y
T
E
D
E
I
V
L
Q
D
I
V
M
D
P
H
S
S
I
V
D
A
K
L
T
K
A
L
-
G
-
N
-
M
V
K
V
F
A
W
Y
D
N
E
W
G
Y
A
N
R
V
A
D
L
V
E
L
V
L
R
K
58
PsiBlast_CBE
91.80
42%
-113
- C4 -
1CER
2
G3P_THEAQ
R:
[1-326]
M
K
V
G
I
N
G
F
G
R
I
G
R
Q
V
F
R
I
L
H
S
R
G
--------
V
E
V
A
L
I
N
D
L
-
T
-
D
N
K
T
L
A
H
L
L
K
Y
D
S
I
Y
H
R
F
-------
P
G
-
E
V
A
Y
D
-
D
Q
Y
L
Y
V
D
G
K
A
I
R
A
-------
T
--
A
-------
V
----
K
------
D
----
P
K
EIPWAEA
G
V
G
V
V
I
E
S
T
G
V
F
T
D
A
D
K
A
K
A
H
L
E
G
G
A
K
K
V
I
I
T
A
P
A
K
G
E
D
-----
I
T
I
V
M
G
V
N
H
-
E
A
Y
DP
S
--
R
--
H
H
--
I
I
S
N
A
S
C
T
T
N
S
L
A
P
V
M
K
V
L
E
E
A
F
G
V
E
K
A
L
M
T
T
V
H
S
Y
T
N
D
Q
R
L
L
D
L
P
H
K
---
D
L
R
R
A
R
A
A
A
I
N
I
I
P
T
T
T
G
A
A
K
A
T
A
L
V
L
P
S
L
K
G
R
F
D
G
M
A
L
R
V
P
T
A
T
G
S
I
S
D
I
T
A
L
L
K
R
E
-
V
T
A
E
E
V
N
A
A
L
K
A
A
A
E
-------
G
P
L
K
G
I
L
A
Y
T
E
D
E
I
V
L
Q
D
I
V
M
D
P
H
S
S
I
V
D
A
K
L
T
K
A
L
-
G
-
N
-
M
V
K
V
F
A
W
Y
D
N
E
W
G
Y
A
N
R
V
A
D
L
V
E
L
V
L
R
K
129
HHSearch
90.89
41%
-105
- C4 -
2D2I
3
?
A:
[3-335]
I
R
V
A
I
N
G
F
G
R
I
G
R
N
F
L
R
C
W
F
G
R
Q
--
N
T
---
D
L
E
V
V
A
I
N
N
T
-
S
-
D
A
R
T
A
A
H
L
L
E
Y
D
S
V
L
G
R
F
-------
N
A
-
D
I
S
Y
D
-
E
N
S
I
T
V
N
G
K
T
M
K
I
------
V
C
D
R
N
-------
P
----
L
------
N
LPWK
E
W
-------
D
I
D
L
V
I
E
S
T
G
V
F
V
T
A
E
G
A
S
K
H
I
Q
A
G
A
K
K
V
L
I
T
A
P
G
K
A
E
----
G
V
G
T
Y
V
I
G
V
N
D
-
S
E
Y
--
R
--
H
ED
F
A
--
V
I
S
N
A
S
C
T
T
N
C
L
A
P
V
A
K
V
L
H
D
N
F
G
I
I
K
G
T
M
T
T
T
H
S
Y
T
L
D
Q
R
I
L
D
A
S
H
R
---
D
L
R
R
A
R
A
A
A
V
N
I
V
P
T
T
T
G
A
A
K
A
V
A
L
V
I
P
E
L
K
G
K
L
N
G
I
A
L
R
V
P
T
P
N
V
S
V
V
D
L
V
V
Q
V
E
K
P
-
T
I
T
E
Q
V
N
E
V
L
Q
K
A
S
Q
-------
T
T
M
K
G
I
I
K
Y
S
D
L
P
L
V
S
S
D
F
R
G
T
D
E
S
S
I
V
D
S
S
L
T
L
V
M
-
D
G
D
-
L
V
K
V
I
A
W
Y
D
N
E
W
G
Y
S
Q
R
V
V
D
L
A
E
L
A
A
R
K
118
HHSearch
90.57
45%
-105
- C4 -
1HDG
3
G3P_THEMA
O:
[1-331]
A
R
V
A
I
N
G
F
G
R
I
G
R
L
V
Y
R
I
I
Y
E
R
K
--
N
P
---
D
I
E
V
V
A
I
N
D
L
-
T
-
D
T
K
T
L
A
H
L
L
K
Y
D
S
V
H
K
K
F
-------
P
G
-
K
V
E
Y
T
-
E
N
S
L
I
V
D
G
K
E
I
K
V
------
F
A
--
E
PD-----
P
----
S
------
K
LPWK
D
L
-------
G
V
D
F
V
I
E
S
T
G
V
F
R
N
R
E
K
A
E
L
H
L
Q
A
G
A
K
K
V
I
I
T
A
P
A
K
G
E
-----
D
I
T
V
V
I
G
C
N
E
-
D
Q
L
--
K
P-
E
--
H
T
--
I
I
S
C
A
S
C
T
T
N
S
I
A
P
I
V
K
V
L
H
E
K
F
G
I
V
S
G
M
L
T
T
V
H
S
Y
T
N
D
Q
R
V
L
D
L
P
H
K
---
D
L
R
R
A
R
A
A
A
V
N
I
I
P
T
T
T
G
A
A
K
A
V
A
L
V
V
P
E
V
K
G
K
L
D
G
M
A
I
R
V
P
T
P
D
G
S
I
T
D
L
T
V
L
V
E
K
E
-
T
T
V
E
E
V
N
A
V
M
K
E
A
T
E
-------
G
R
L
K
G
I
I
G
Y
N
D
E
P
I
V
S
S
D
I
I
G
T
T
F
S
G
I
F
D
A
T
I
T
N
V
I
-
G
G
K
-
L
V
K
V
A
S
W
Y
D
N
E
Y
G
Y
S
N
R
V
V
D
T
L
E
L
L
L
K
M
23
PsiBlast_CBE
90.53
42%
-111
- C4 -
4DBV
3
G3P_GEOSE
P:
[2-329]
V
K
V
G
I
N
G
F
G
R
I
G
R
N
V
F
R
A
A
L
K
----
N
P
---
D
I
E
V
V
A
V
N
D
T
-
G
-
G
A
N
T
L
A
H
L
L
K
Y
D
S
V
H
G
R
L
-------
D
A
-
E
V
S
V
N
-
G
N
N
L
V
V
N
G
K
E
I
-
I
------
V
K
--
A
-------
E
----
R
------
D
----
P
E
NLAWGEI
G
V
D
I
V
V
E
S
T
G
R
F
T
K
R
E
D
A
A
K
H
L
E
A
G
A
K
K
V
I
I
S
A
P
A
K
N
E
D
-----
I
T
I
V
M
G
V
N
Q
-
D
K
Y
--
D
--
P
--
K
A
HH
V
I
S
N
A
S
C
T
T
N
C
L
A
P
F
A
K
V
L
H
E
Q
F
G
I
V
R
G
M
M
T
T
V
H
S
Y
T
N
D
Q
R
I
L
D
A
S
H
K
---
D
L
R
R
A
R
A
A
A
E
S
I
I
P
T
T
T
G
A
A
K
A
V
A
L
V
L
P
E
L
K
G
K
L
N
G
M
A
M
R
V
P
T
P
N
V
S
V
V
D
L
V
A
E
L
E
K
E
-
V
T
V
E
E
V
N
A
A
L
K
A
A
A
E
-------
G
E
L
K
G
I
L
A
Y
S
E
E
P
L
V
S
R
D
Y
N
G
S
T
V
S
S
T
I
D
A
L
S
T
M
V
I
-
D
-
G
K
M
V
K
V
V
S
W
Y
D
N
E
T
G
Y
S
H
R
V
V
D
L
A
A
Y
I
A
S
K
46
PsiBlast_CBE
90.51
42%
-112
- C4 -
1DBV
3
G3P_GEOSE
R:
[2-329]
V
K
V
G
I
N
G
F
G
R
I
G
R
N
V
F
R
A
A
L
K
----
N
P
---
D
I
E
V
V
A
V
N
G
L
-
T
-
D
A
N
T
L
A
H
L
L
K
Y
D
S
V
H
G
R
L
-------
D
A
-
E
V
S
V
N
-
G
N
N
L
V
V
N
G
K
E
I
-
I
------
V
K
--
A
-------
E
----
R
------
D
----
P
E
NLAWGEI
G
V
D
I
V
V
E
S
T
G
R
F
T
K
R
E
D
A
A
K
H
L
E
A
G
A
K
K
V
I
I
S
A
P
A
K
N
E
D
-----
I
T
I
V
M
G
V
N
Q
-
D
K
Y
--
D
--
P
--
K
A
HH
V
I
S
N
A
S
C
T
T
N
C
L
A
P
F
A
K
V
L
H
E
Q
F
G
I
V
R
G
M
M
T
T
V
H
S
Y
T
N
D
Q
R
I
L
D
A
S
H
K
---
D
L
R
R
A
R
A
A
A
E
S
I
I
P
T
T
T
G
A
A
K
A
V
A
L
V
L
P
E
L
K
G
K
L
N
G
M
A
M
R
V
P
T
P
N
V
S
V
V
D
L
V
A
E
L
E
K
E
-
V
T
V
E
E
V
N
A
A
L
K
A
A
A
E
-------
G
E
L
K
G
I
L
A
Y
S
E
E
P
L
V
S
R
D
Y
N
G
S
T
V
S
S
T
I
D
A
L
S
T
M
V
I
-
D
-
G
K
M
V
K
V
V
S
W
Y
D
N
E
T
G
Y
S
H
R
V
V
D
L
A
A
Y
I
A
S
K
24
PsiBlast_CBE
90.50
42%
-111
- C4 -
3DBV
3
G3P_GEOSE
R:
[2-329]
V
K
V
G
I
N
G
F
G
R
I
G
R
N
V
F
R
A
A
L
K
----
N
P
---
D
I
E
V
V
A
V
N
D
T
-
G
-
G
A
N
T
L
A
H
L
L
K
Y
D
S
V
H
G
R
L
-------
D
A
-
E
V
S
V
N
-
G
N
N
L
V
V
N
G
K
E
I
-
I
------
V
K
--
A
-------
E
----
R
------
D
----
P
E
NLAWGEI
G
V
D
I
V
V
E
S
T
G
R
F
T
K
R
E
D
A
A
K
H
L
E
A
G
A
K
K
V
I
I
S
A
P
A
K
N
E
D
-----
I
T
I
V
M
G
V
N
Q
-
D
K
Y
--
D
--
P
--
K
A
HH
V
I
S
N
A
S
C
T
T
N
C
L
A
P
F
A
K
V
L
H
E
Q
F
G
I
V
R
G
M
M
T
T
V
H
S
Y
T
N
D
Q
R
I
L
D
A
S
H
K
---
D
L
R
R
A
R
A
A
A
E
S
I
I
P
T
T
T
G
A
A
K
A
V
A
L
V
L
P
E
L
K
G
K
L
N
G
M
A
M
R
V
P
T
P
N
V
S
V
V
D
L
V
A
E
L
E
K
E
-
V
T
V
E
E
V
N
A
A
L
K
A
A
A
E
-------
G
E
L
K
G
I
L
A
Y
S
E
E
P
L
V
S
R
D
Y
N
G
S
T
V
S
S
T
I
D
A
L
S
T
M
V
I
-
D
-
G
K
M
V
K
V
V
S
W
Y
D
N
E
T
G
Y
S
H
R
V
V
D
L
A
A
Y
I
A
S
K
21
PsiBlast_CBE
90.49
42%
-112
- C4 -
4DBV
3
G3P_GEOSE
R:
[2-329]
V
K
V
G
I
N
G
F
G
R
I
G
R
N
V
F
R
A
A
L
K
----
N
P
---
D
I
E
V
V
A
V
N
D
T
-
G
-
G
A
N
T
L
A
H
L
L
K
Y
D
S
V
H
G
R
L
-------
D
A
-
E
V
S
V
N
-
G
N
N
L
V
V
N
G
K
E
I
-
I
------
V
K
--
A
-------
E
----
R
------
D
----
P
E
NLAWGEI
G
V
D
I
V
V
E
S
T
G
R
F
T
K
R
E
D
A
A
K
H
L
E
A
G
A
K
K
V
I
I
S
A
P
A
K
N
E
D
-----
I
T
I
V
M
G
V
N
Q
-
D
K
Y
--
D
--
P
--
K
A
HH
V
I
S
N
A
S
C
T
T
N
C
L
A
P
F
A
K
V
L
H
E
Q
F
G
I
V
R
G
M
M
T
T
V
H
S
Y
T
N
D
Q
R
I
L
D
A
S
H
K
---
D
L
R
R
A
R
A
A
A
E
S
I
I
P
T
T
T
G
A
A
K
A
V
A
L
V
L
P
E
L
K
G
K
L
N
G
M
A
M
R
V
P
T
P
N
V
S
V
V
D
L
V
A
E
L
E
K
E
-
V
T
V
E
E
V
N
A
A
L
K
A
A
A
E
-------
G
E
L
K
G
I
L
A
Y
S
E
E
P
L
V
S
R
D
Y
N
G
S
T
V
S
S
T
I
D
A
L
S
T
M
V
I
-
D
-
G
K
M
V
K
V
V
S
W
Y
D
N
E
T
G
Y
S
H
R
V
V
D
L
A
A
Y
I
A
S
K
64
PsiBlast_CBE
90.43
42%
-110
- C4 -
1CER
2
G3P_THEAQ
A:
[1-326]
M
K
V
G
I
N
G
F
G
R
I
G
R
Q
V
F
R
I
L
H
S
R
G
--------
V
E
V
A
L
I
N
D
L
-
T
-
D
N
K
T
L
A
H
L
L
K
Y
D
S
I
Y
H
R
F
-------
P
G
-
E
V
A
Y
D
-
D
Q
Y
L
Y
V
D
G
K
A
I
R
A
-------
T
--
A
-------
V
----
K
------
D
----
P
K
EIPWAEA
G
V
G
V
V
I
E
S
T
G
V
F
T
D
A
D
K
A
K
A
H
L
E
G
G
A
K
K
V
I
I
T
A
P
A
K
G
E
D
-----
I
T
I
V
M
G
V
N
H
-
E
A
Y
DP
S
--
R
--
H
H
--
I
I
S
N
A
S
C
T
T
N
S
L
A
P
V
M
K
V
L
E
E
A
F
G
V
E
K
A
L
M
T
T
V
H
S
Y
T
N
D
Q
R
L
L
D
L
P
H
K
---
D
L
R
R
A
R
A
A
A
I
N
I
I
P
T
T
T
G
A
A
K
A
T
A
L
V
L
P
S
L
K
G
R
F
D
G
M
A
L
R
V
P
T
A
T
G
S
I
S
D
I
T
A
L
L
K
R
E
-
V
T
A
E
E
V
N
A
A
L
K
A
A
A
E
-------
G
P
L
K
G
I
L
A
Y
T
E
D
E
I
V
L
Q
D
I
V
M
D
P
H
S
S
I
V
D
A
K
L
T
K
A
L
-
G
-
N
-
M
V
K
V
F
A
W
Y
D
N
E
W
G
Y
A
N
R
V
A
D
L
V
E
L
V
L
R
K
57
PsiBlast_CBE
90.36
41%
-104
- C4 -
4P8R
3
?
B:
[11-333]
I
R
V
G
I
N
G
F
G
R
I
G
R
V
V
F
R
A
A
Q
R
R
N
D
-------
I
E
I
V
G
I
N
D
L
-
L
-
D
A
D
Y
M
A
Y
M
L
K
Y
D
S
T
H
G
R
F
-------
E
G
-
A
V
E
V
Q
-
G
G
A
L
V
V
N
G
K
K
I
R
V
-------
T
--
S
-------
E
----
R
------
D
PAN-
L
K
WNEI---
N
V
D
V
V
V
E
S
T
G
L
F
L
S
D
D
T
A
R
K
H
I
Q
A
G
A
K
K
V
V
I
T
G
P
-----
S
K
D
D
T
P
M
F
V
M
G
V
N
H
-
T
T
Y
--
K
--
G
--
E
A
--
I
V
S
N
A
S
C
T
T
N
C
L
A
P
L
A
K
V
L
N
D
K
F
G
I
V
E
G
L
M
T
T
V
H
A
T
T
A
T
Q
K
T
V
D
G
P
S
Q
--
K
D
W
R
G
G
R
G
A
A
Q
N
I
I
P
S
S
T
G
A
A
K
A
V
G
K
I
I
P
S
L
N
G
K
L
T
G
M
A
F
R
V
P
T
P
N
V
S
V
V
D
L
T
V
R
L
E
R
P
-
A
T
Y
K
Q
I
C
D
A
I
K
A
A
S
E
-------
G
E
L
K
G
I
L
G
Y
V
D
E
E
I
V
S
S
D
I
N
G
I
P
L
T
S
V
F
D
A
R
A
G
I
S
L
N
D
-
N
-
F
V
K
L
V
S
W
Y
D
N
E
T
G
Y
S
N
K
V
L
D
L
I
A
H
I
T
K
-
63
PsiBlast_CBE
90.23
42%
-108
- C4 -
1CER
2
G3P_THEAQ
B:
[1-326]
M
K
V
G
I
N
G
F
G
R
I
G
R
Q
V
F
R
I
L
H
S
R
G
--------
V
E
V
A
L
I
N
D
L
-
T
-
D
N
K
T
L
A
H
L
L
K
Y
D
S
I
Y
H
R
F
-------
P
G
-
E
V
A
Y
D
-
D
Q
Y
L
Y
V
D
G
K
A
I
R
A
-------
T
--
A
-------
V
----
K
------
D
----
P
K
EIPWAEA
G
V
G
V
V
I
E
S
T
G
V
F
T
D
A
D
K
A
K
A
H
L
E
G
G
A
K
K
V
I
I
T
A
P
A
K
G
E
D
-----
I
T
I
V
M
G
V
N
H
-
E
A
Y
DP
S
--
R
--
H
H
--
I
I
S
N
A
S
C
T
T
N
S
L
A
P
V
M
K
V
L
E
E
A
F
G
V
E
K
A
L
M
T
T
V
H
S
Y
T
N
D
Q
R
L
L
D
L
P
H
K
---
D
L
R
R
A
R
A
A
A
I
N
I
I
P
T
T
T
G
A
A
K
A
T
A
L
V
L
P
S
L
K
G
R
F
D
G
M
A
L
R
V
P
T
A
T
G
S
I
S
D
I
T
A
L
L
K
R
E
-
V
T
A
E
E
V
N
A
A
L
K
A
A
A
E
-------
G
P
L
K
G
I
L
A
Y
T
E
D
E
I
V
L
Q
D
I
V
M
D
P
H
S
S
I
V
D
A
K
L
T
K
A
L
-
G
-
N
-
M
V
K
V
F
A
W
Y
D
N
E
W
G
Y
A
N
R
V
A
D
L
V
E
L
V
L
R
K
6
PsiBlast_PDB
89.46
44%
-108
- C4 -
1HDG
3
G3P_THEMA
O:
[2-329]
-
R
V
A
I
N
G
F
G
R
I
G
R
L
V
Y
R
I
I
Y
E
R
K
--
N
P
---
D
I
E
V
V
A
I
N
D
L
-
T
-
D
T
K
T
L
A
H
L
L
K
Y
D
S
V
H
K
K
F
-------
P
G
-
K
V
E
Y
T
-
E
N
S
L
I
V
D
G
K
E
I
K
V
------
F
A
--
E
PDPSKLP
W
----
K
------
D
----
L
--------
G
V
D
F
V
I
E
S
T
G
V
F
R
N
R
E
K
A
E
L
H
L
Q
A
G
A
K
K
V
I
I
T
A
P
A
K
G
E
D
-----
I
T
V
V
I
G
C
N
E
D
Q
L
K
--
P
--
E
--
H
T
--
I
I
S
C
A
S
C
T
T
N
S
I
A
P
I
V
K
V
L
H
E
K
F
G
I
V
S
G
M
L
T
T
V
H
S
Y
T
N
D
Q
R
V
L
D
L
P
H
K
---
D
L
R
R
A
R
A
A
A
V
N
I
I
P
T
T
T
G
A
A
K
A
V
A
L
V
V
P
E
V
K
G
K
L
D
G
M
A
I
R
V
P
T
P
D
G
S
I
T
D
L
T
V
L
V
E
K
E
-
T
T
V
E
E
V
N
A
V
M
K
E
A
T
E
-------
G
R
L
K
G
I
I
G
Y
N
D
E
P
I
V
S
S
D
I
I
G
T
T
F
S
G
I
F
D
A
T
I
T
N
V
I
-
G
-
G
K
L
V
K
V
A
S
W
Y
D
N
E
Y
G
Y
S
N
R
V
V
D
T
L
E
L
L
L
K
M
13
PsiBlast_PDB
89.22
41%
-104
- C4 -
4P8R
3
?
A:
[11-333]
I
R
V
G
I
N
G
F
G
R
I
G
R
V
V
F
R
A
A
Q
R
R
N
D
-------
I
E
I
V
G
I
N
D
L
-
L
-
D
A
D
Y
M
A
Y
M
L
K
Y
D
S
T
H
G
R
F
-------
E
G
-
A
V
E
V
Q
-
G
G
A
L
V
V
N
G
K
K
I
R
V
-------
T
--
S
-------
E
----
R
------
D
PAN-
L
K
WNEI---
N
V
D
V
V
V
E
S
T
G
L
F
L
S
D
D
T
A
R
K
H
I
Q
A
G
A
K
K
V
V
I
T
G
P
-----
S
K
D
D
T
P
M
F
V
M
G
V
N
H
-
T
T
Y
--
K
--
G
--
E
A
--
I
V
S
N
A
S
C
T
T
N
C
L
A
P
L
A
K
V
L
N
D
K
F
G
I
V
E
G
L
M
T
T
V
H
A
T
T
A
T
Q
K
T
V
D
G
P
S
Q
--
K
D
W
R
G
G
R
G
A
A
Q
N
I
I
P
S
S
T
G
A
A
K
A
V
G
K
I
I
P
S
L
N
G
K
L
T
G
M
A
F
R
V
P
T
P
N
V
S
V
V
D
L
T
V
R
L
E
R
P
-
A
T
Y
K
Q
I
C
D
A
I
K
A
A
S
E
-------
G
E
L
K
G
I
L
G
Y
V
D
E
E
I
V
S
S
D
I
N
G
I
P
L
T
S
V
F
D
A
R
A
G
I
S
L
N
D
-
N
-
F
V
K
L
V
S
W
Y
D
N
E
T
G
Y
S
N
K
V
L
D
L
I
A
H
I
T
K
-
86
PsiBlast_CBE
88.46
40%
-99
- C4 -
1S7C
6
G3P1_ECOLI
A:
[3-325]
I
K
V
G
I
N
G
F
G
R
I
G
R
I
V
F
R
A
A
Q
K
R
S
D
-------
I
E
I
V
A
I
N
D
L
-
L
-
D
A
D
Y
M
A
Y
M
L
K
Y
D
S
T
H
G
R
F
-------
D
G
-
T
V
E
V
K
-
D
G
H
L
I
V
N
G
K
K
I
R
V
T
A
E
RDP
A
N
--
L
-------
K
----
W
------
D
----
E
V
-------
G
V
D
V
V
A
E
A
T
G
L
F
L
T
D
E
T
A
R
K
H
I
T
A
G
A
K
K
V
V
M
T
G
P
-----
S
K
D
N
T
P
M
F
V
K
G
A
N
F
-
D
K
Y
--
A
--
G
--
Q
D
--
I
V
S
N
A
S
C
T
T
N
C
L
A
P
L
A
K
V
I
N
D
N
F
G
I
I
E
G
L
M
T
T
V
H
A
T
T
A
T
Q
K
T
V
D
G
P
S
H
--
K
D
W
R
G
G
R
G
A
S
Q
N
I
I
P
S
S
T
G
A
A
K
A
V
G
K
V
L
P
E
L
N
G
K
L
T
G
M
A
F
R
V
P
T
P
N
V
S
V
V
D
L
T
V
R
L
E
K
A
-
A
T
Y
E
Q
I
K
A
A
V
K
A
A
A
E
-------
G
E
M
K
G
V
L
G
Y
T
E
D
D
V
V
S
T
D
F
N
G
E
V
C
T
S
V
F
D
A
K
A
G
I
A
L
N
D
-
N
-
F
V
K
L
V
S
W
Y
D
N
E
T
G
Y
S
N
K
V
L
D
L
I
A
H
I
S
K
-
16
PsiBlast_PDB
88.35
42%
-106
- C4 -
1VC2
1
?
A:
[1-326]
M
K
V
G
I
N
G
F
G
R
I
G
R
Q
V
F
R
I
L
H
E
R
G
--------
V
E
V
A
L
I
N
D
L
-
T
-
D
N
K
T
L
A
H
L
L
K
Y
D
S
T
Y
G
R
F
-------
P
G
-
A
V
G
Y
D
-
E
E
N
L
Y
V
D
G
K
A
I
R
A
-------
T
--
A
-------
I
----
K
------
D
----
P
R
EIPWKQA
G
V
G
V
V
V
E
S
T
G
V
F
T
D
G
E
K
A
R
A
H
L
E
A
G
A
K
K
V
I
I
T
A
P
A
K
N
E
D
-----
I
T
V
V
L
G
V
N
H
-
E
Q
Y
--
D
PA
K
--
H
H
--
I
L
S
N
A
S
C
T
T
N
S
L
A
P
V
M
K
V
L
E
K
A
F
G
V
E
K
A
L
M
T
T
V
H
S
Y
T
N
D
Q
R
L
L
D
L
P
H
K
---
D
L
R
R
A
R
A
A
A
L
N
I
I
P
T
T
T
G
A
A
K
A
T
A
L
V
L
P
S
L
K
G
R
F
D
G
M
A
L
R
V
P
T
P
T
G
S
I
S
D
I
T
A
L
L
K
R
E
-
V
T
A
E
E
V
N
A
A
L
K
A
A
A
E
-------
G
P
L
K
G
I
L
A
Y
T
E
D
E
I
V
L
R
D
I
V
M
D
P
H
S
S
I
V
D
G
K
L
T
K
A
I
-
G
-
N
-
L
V
K
V
F
A
W
Y
D
N
E
W
G
Y
A
N
R
V
A
D
L
V
E
L
V
L
K
K
90
PsiBlast_CBE
87.63
38%
-103
- C4 -
3H9E
10
G3PT_HUMAN
O:
[8-336]
L
T
V
G
I
N
G
F
G
R
I
G
R
L
V
L
R
A
C
M
E
K
G
--------
V
K
V
V
A
V
N
D
P
F
I
-
D
P
E
Y
M
V
Y
M
F
K
Y
D
S
T
H
G
R
Y
-------
K
G
-
S
V
E
F
R
-
N
G
Q
L
V
V
D
N
H
E
I
S
V
------
Y
Q
--
C
-------
K
----
E
------
P
----
K
Q
IPWRAV-
G
S
P
Y
V
V
E
S
T
G
V
Y
L
S
I
Q
A
A
S
D
H
I
S
A
G
A
Q
R
V
V
I
S
A
P
------
S
P
D
A
P
M
F
V
M
G
V
N
E
-
N
D
Y
--
N
PG
S
--
M
N
--
I
V
S
N
A
S
C
T
T
N
C
L
A
P
L
A
K
V
I
H
E
R
F
G
I
V
E
G
L
M
T
T
V
H
S
Y
T
A
T
Q
K
T
V
D
G
P
S
R
--
K
A
W
R
D
G
R
G
A
H
Q
N
I
I
P
A
S
T
G
A
A
K
A
V
T
K
V
I
P
E
L
K
G
K
L
T
G
M
A
F
R
V
P
T
P
D
V
S
V
V
D
L
T
C
R
L
A
Q
P
-
A
P
Y
S
A
I
K
E
A
V
K
A
A
A
K
-------
G
P
M
A
G
I
L
A
Y
T
E
D
E
V
V
S
T
D
F
L
G
D
T
H
S
S
I
F
D
A
K
A
G
I
A
L
N
D
-
N
-
F
V
K
L
I
S
W
Y
D
N
E
Y
G
Y
S
H
R
V
V
D
L
L
R
Y
M
F
S
R
88
PsiBlast_CBE
87.33
38%
-106
- C4 -
3PFW
4
G3PT_HUMAN
O:
[8-336]
L
T
V
G
I
N
G
F
G
R
I
G
R
L
V
L
R
A
C
M
E
K
G
--------
V
K
V
V
A
V
N
D
P
F
I
-
D
P
E
Y
M
V
Y
M
F
K
Y
D
S
T
H
G
R
Y
-------
K
G
-
S
V
E
F
R
-
N
G
Q
L
V
V
D
N
H
E
I
S
V
------
Y
Q
--
C
-------
K
----
E
------
P
----
K
Q
IPWRAV-
G
S
P
Y
V
V
E
S
T
G
V
Y
L
S
I
Q
A
A
S
D
H
I
S
A
G
A
Q
R
V
V
I
S
A
P
------
S
P
D
A
P
M
F
V
M
G
V
N
E
-
N
D
Y
--
N
PG
S
--
M
N
--
I
V
S
N
A
S
C
T
T
N
C
L
A
P
L
A
K
V
I
H
E
R
F
G
I
V
E
G
L
M
T
T
V
H
S
Y
T
A
T
Q
K
T
V
D
G
P
S
R
--
K
A
W
R
D
G
R
G
A
H
Q
N
I
I
P
A
S
T
G
A
A
K
A
V
T
K
V
I
P
E
L
K
G
K
L
T
G
M
A
F
R
V
P
T
P
D
V
S
V
V
D
L
T
C
R
L
A
Q
P
-
A
P
Y
S
A
I
K
E
A
V
K
A
A
A
K
-------
G
P
M
A
G
I
L
A
Y
T
E
D
E
V
V
S
T
D
F
L
G
D
T
H
S
S
I
F
D
A
K
A
G
I
A
L
N
D
-
N
-
F
V
K
L
I
S
W
Y
D
N
E
Y
G
Y
S
H
R
V
V
D
L
L
R
Y
M
F
S
R
36
PsiBlast_CBE
87.25
44%
-108
- C4 -
1HDG
3
G3P_THEMA
Q:
[2-329]
-
R
V
A
I
N
G
F
G
R
I
G
R
L
V
Y
R
I
I
Y
E
R
K
--
N
P
---
D
I
E
V
V
A
I
N
D
L
-
T
-
D
T
K
T
L
A
H
L
L
K
Y
D
S
V
H
K
K
F
-------
P
G
-
K
V
E
Y
T
-
E
N
S
L
I
V
D
G
K
E
I
K
V
------
F
A
--
E
PDPSKLP
W
----
K
------
D
----
L
--------
G
V
D
F
V
I
E
S
T
G
V
F
R
N
R
E
K
A
E
L
H
L
Q
A
G
A
K
K
V
I
I
T
A
P
A
K
G
E
D
-----
I
T
V
V
I
G
C
N
E
D
Q
L
K
--
P
--
E
--
H
T
--
I
I
S
C
A
S
C
T
T
N
S
I
A
P
I
V
K
V
L
H
E
K
F
G
I
V
S
G
M
L
T
T
V
H
S
Y
T
N
D
Q
R
V
L
D
L
P
H
K
---
D
L
R
R
A
R
A
A
A
V
N
I
I
P
T
T
T
G
A
A
K
A
V
A
L
V
V
P
E
V
K
G
K
L
D
G
M
A
I
R
V
P
T
P
D
G
S
I
T
D
L
T
V
L
V
E
K
E
-
T
T
V
E
E
V
N
A
V
M
K
E
A
T
E
-------
G
R
L
K
G
I
I
G
Y
N
D
E
P
I
V
S
S
D
I
I
G
T
T
F
S
G
I
F
D
A
T
I
T
N
V
I
-
G
-
G
K
L
V
K
V
A
S
W
Y
D
N
E
Y
G
Y
S
N
R
V
V
D
T
L
E
L
L
L
K
M
82
PsiBlast_CBE
87.23
40%
-101
- C4 -
1GAD
1
G3P1_ECOLI
P:
[2-324]
I
K
V
G
I
N
G
F
G
R
I
G
R
I
V
F
R
A
A
Q
K
R
S
D
-------
I
E
I
V
A
I
N
D
L
-
L
-
D
A
D
Y
M
A
Y
M
L
K
Y
D
S
T
H
G
R
F
-------
D
G
-
T
V
E
V
K
-
D
G
H
L
I
V
N
G
K
K
I
R
V
TAERDP
A
N
--
L
-------
K
----
W
------
D
----
E
V
-------
G
V
D
V
V
A
E
A
T
G
L
F
L
T
D
E
T
A
R
K
H
I
T
A
G
A
K
K
V
V
M
T
G
P
-----
S
K
D
N
T
P
M
F
V
K
G
A
N
F
-
D
K
Y
--
A
--
G
--
Q
D
--
I
V
S
N
A
S
C
T
T
N
C
L
A
P
L
A
K
V
I
N
D
N
F
G
I
I
E
G
L
M
T
T
V
H
A
T
T
A
T
Q
K
T
V
D
G
P
S
H
--
K
D
W
R
G
G
R
G
A
S
Q
N
I
I
P
S
S
T
G
A
A
K
A
V
G
K
V
L
P
E
L
N
G
K
L
T
G
M
A
F
R
V
P
T
P
N
V
S
V
V
D
L
T
V
R
L
E
K
A
-
A
T
Y
E
Q
I
K
A
A
V
K
A
A
A
E
-------
G
E
M
K
G
V
L
G
Y
T
E
D
D
V
V
S
T
D
F
N
G
E
V
C
T
S
V
F
D
A
K
A
G
I
A
L
N
D
-
N
-
F
V
K
L
V
S
W
Y
D
N
E
T
G
Y
S
N
K
V
L
D
L
I
A
H
I
S
K
-
56
PsiBlast_CBE
87.16
41%
-102
- C4 -
4P8R
2
?
C:
[11-333]
I
R
V
G
I
N
G
F
G
R
I
G
R
V
V
F
R
A
A
Q
R
R
N
D
-------
I
E
I
V
G
I
N
D
L
-
L
-
D
A
D
Y
M
A
Y
M
L
K
Y
D
S
T
H
G
R
F
-------
E
G
-
A
V
E
V
Q
-
G
G
A
L
V
V
N
G
K
K
I
R
V
-------
T
--
S
-------
E
----
R
------
D
PAN-
L
K
WNEI---
N
V
D
V
V
V
E
S
T
G
L
F
L
S
D
D
T
A
R
K
H
I
Q
A
G
A
K
K
V
V
I
T
G
P
-----
S
K
D
D
T
P
M
F
V
M
G
V
N
H
-
T
T
Y
--
K
--
G
--
E
A
--
I
V
S
N
A
S
C
T
T
N
C
L
A
P
L
A
K
V
L
N
D
K
F
G
I
V
E
G
L
M
T
T
V
H
A
T
T
A
T
Q
K
T
V
D
G
P
S
Q
--
K
D
W
R
G
G
R
G
A
A
Q
N
I
I
P
S
S
T
G
A
A
K
A
V
G
K
I
I
P
S
L
N
G
K
L
T
G
M
A
F
R
V
P
T
P
N
V
S
V
V
D
L
T
V
R
L
E
R
P
-
A
T
Y
K
Q
I
C
D
A
I
K
A
A
S
E
-------
G
E
L
K
G
I
L
G
Y
V
D
E
E
I
V
S
S
D
I
N
G
I
P
L
T
S
V
F
D
A
R
A
G
I
S
L
N
D
-
N
-
F
V
K
L
V
S
W
Y
D
N
E
T
G
Y
S
N
K
V
L
D
L
I
A
H
I
T
K
-
70
PsiBlast_CBE
86.91
41%
-99
- C4 -
3ZDF
2
?
B:
[19-349]
V
R
V
A
I
N
G
F
G
R
I
G
R
N
F
M
R
C
W
L
Q
R
K
-
A
N
S
---
K
L
E
I
V
G
I
N
D
T
-
S
-
D
P
R
T
N
A
H
L
L
K
Y
D
S
M
L
G
I
F
QDAEITA
D
D
-
D
C
I
Y
A
-
G
G
H
A
V
K
C
V
S
D
R
N
P
------
E
N
--
L
-------
P
----
W
------
S
----
A
W
-------
G
I
D
L
V
I
E
A
T
G
V
F
T
S
R
E
G
A
S
K
H
L
S
A
G
A
K
K
V
L
I
T
A
P
G
K
G
-----
N
I
P
T
Y
V
V
G
V
N
H
-
H
T
Y
--
D
P-
S
--
E
D
--
I
V
S
N
A
S
C
T
T
N
C
L
A
P
I
V
K
V
L
H
E
A
F
G
I
Q
Q
G
M
M
T
T
T
H
S
Y
T
G
D
Q
R
L
L
D
A
S
H
---
R
D
L
R
R
A
R
A
A
A
M
N
I
V
P
T
S
T
G
A
A
K
A
V
G
L
V
I
P
E
L
Q
G
K
L
N
G
I
A
L
R
V
P
T
P
N
V
S
V
V
D
F
V
A
Q
V
E
K
P
-
T
I
A
E
Q
V
N
Q
V
I
K
E
A
S
E
-------
T
T
M
K
G
I
I
H
Y
S
E
L
E
L
V
S
S
D
Y
R
G
H
N
A
S
S
I
L
D
A
S
L
T
M
V
L
G
G
-
N
-
L
V
K
V
V
A
W
Y
D
N
E
W
G
Y
S
Q
R
V
L
D
L
A
E
H
M
A
A
H
100
PsiBlast_CBE
86.86
40%
-107
- C4 -
1SZJ
3
G3P_PANVR
G:
[2-327]
-
K
I
G
I
N
G
F
G
R
I
G
R
L
V
L
R
A
A
L
E
M
G
--------
A
Q
V
V
A
V
N
D
P
F
I
-
A
L
E
Y
M
V
Y
M
F
K
Y
D
S
T
H
G
M
F
-------
K
G
-
E
V
K
A
E
-
D
G
A
L
V
V
D
G
K
K
I
T
V
------
F
N
--
E
-------
M
----
K
PENIPW
S
----
K
A
-------
G
A
E
Y
I
V
E
S
T
G
V
F
T
T
I
E
K
A
S
A
H
F
K
G
G
A
K
K
V
I
I
S
A
P
------
S
A
D
A
P
M
F
V
C
G
V
N
L
-
E
K
Y
S-
K
--
D
--
M
K
--
V
V
S
N
A
S
C
T
T
N
C
L
A
P
V
A
K
V
L
H
E
N
F
E
I
V
E
G
L
M
T
T
V
H
A
V
T
A
T
Q
K
T
V
D
G
P
S
A
--
K
D
W
R
G
G
R
G
A
A
Q
N
I
I
P
S
S
T
G
A
A
K
A
V
G
K
V
I
P
E
L
D
G
K
L
T
G
M
A
F
R
V
P
T
P
N
V
S
V
V
D
L
T
V
R
L
G
K
E
-
C
S
Y
D
D
I
K
A
A
M
K
A
A
S
E
-------
G
P
L
Q
G
V
L
G
Y
T
E
D
D
V
V
S
C
D
F
T
G
D
N
R
S
S
I
F
D
A
K
A
G
I
Q
L
S
K
-
T
-
F
V
K
V
V
S
W
Y
D
N
E
F
G
Y
S
Q
R
V
I
D
L
I
K
H
M
Q
K
V
87
PsiBlast_CBE
86.81
38%
-104
- C4 -
3PFW
3
G3PT_HUMAN
P:
[8-336]
L
T
V
G
I
N
G
F
G
R
I
G
R
L
V
L
R
A
C
M
E
K
G
--------
V
K
V
V
A
V
N
D
P
F
I
-
D
P
E
Y
M
V
Y
M
F
K
Y
D
S
T
H
G
R
Y
-------
K
G
-
S
V
E
F
R
-
N
G
Q
L
V
V
D
N
H
E
I
S
V
------
Y
Q
--
C
-------
K
----
E
------
P
----
K
Q
IPWRAV-
G
S
P
Y
V
V
E
S
T
G
V
Y
L
S
I
Q
A
A
S
D
H
I
S
A
G
A
Q
R
V
V
I
S
A
P
------
S
P
D
A
P
M
F
V
M
G
V
N
E
-
N
D
Y
--
N
PG
S
--
M
N
--
I
V
S
N
A
S
C
T
T
N
C
L
A
P
L
A
K
V
I
H
E
R
F
G
I
V
E
G
L
M
T
T
V
H
S
Y
T
A
T
Q
K
T
V
D
G
P
S
R
--
K
A
W
R
D
G
R
G
A
H
Q
N
I
I
P
A
S
T
G
A
A
K
A
V
T
K
V
I
P
E
L
K
G
K
L
T
G
M
A
F
R
V
P
T
P
D
V
S
V
V
D
L
T
C
R
L
A
Q
P
-
A
P
Y
S
A
I
K
E
A
V
K
A
A
A
K
-------
G
P
M
A
G
I
L
A
Y
T
E
D
E
V
V
S
T
D
F
L
G
D
T
H
S
S
I
F
D
A
K
A
G
I
A
L
N
D
-
N
-
F
V
K
L
I
S
W
Y
D
N
E
Y
G
Y
S
H
R
V
V
D
L
L
R
Y
M
F
S
R
99
PsiBlast_CBE
86.77
40%
-109
- C4 -
1SZJ
3
G3P_PANVR
R:
[2-327]
-
K
I
G
I
N
G
F
G
R
I
G
R
L
V
L
R
A
A
L
E
M
G
--------
A
Q
V
V
A
V
N
D
P
F
I
-
A
L
E
Y
M
V
Y
M
F
K
Y
D
S
T
H
G
M
F
-------
K
G
-
E
V
K
A
E
-
D
G
A
L
V
V
D
G
K
K
I
T
V
------
F
N
--
E
-------
M
----
K
PENIPW
S
----
K
A
-------
G
A
E
Y
I
V
E
S
T
G
V
F
T
T
I
E
K
A
S
A
H
F
K
G
G
A
K
K
V
I
I
S
A
P
------
S
A
D
A
P
M
F
V
C
G
V
N
L
-
E
K
Y
S-
K
--
D
--
M
K
--
V
V
S
N
A
S
C
T
T
N
C
L
A
P
V
A
K
V
L
H
E
N
F
E
I
V
E
G
L
M
T
T
V
H
A
V
T
A
T
Q
K
T
V
D
G
P
S
A
--
K
D
W
R
G
G
R
G
A
A
Q
N
I
I
P
S
S
T
G
A
A
K
A
V
G
K
V
I
P
E
L
D
G
K
L
T
G
M
A
F
R
V
P
T
P
N
V
S
V
V
D
L
T
V
R
L
G
K
E
-
C
S
Y
D
D
I
K
A
A
M
K
A
A
S
E
-------
G
P
L
Q
G
V
L
G
Y
T
E
D
D
V
V
S
C
D
F
T
G
D
N
R
S
S
I
F
D
A
K
A
G
I
Q
L
S
K
-
T
-
F
V
K
V
V
S
W
Y
D
N
E
F
G
Y
S
Q
R
V
I
D
L
I
K
H
M
Q
K
V
89
PsiBlast_CBE
86.58
38%
-106
- C4 -
3H9E
14
G3PT_HUMAN
P:
[8-336]
L
T
V
G
I
N
G
F
G
R
I
G
R
L
V
L
R
A
C
M
E
K
G
--------
V
K
V
V
A
V
N
D
P
F
I
-
D
P
E
Y
M
V
Y
M
F
K
Y
D
S
T
H
G
R
Y
-------
K
G
-
S
V
E
F
R
-
N
G
Q
L
V
V
D
N
H
E
I
S
V
------
Y
Q
--
C
-------
K
----
E
------
P
----
K
Q
IPWRAV-
G
S
P
Y
V
V
E
S
T
G
V
Y
L
S
I
Q
A
A
S
D
H
I
S
A
G
A
Q
R
V
V
I
S
A
P
------
S
P
D
A
P
M
F
V
M
G
V
N
E
-
N
D
Y
--
N
PG
S
--
M
N
--
I
V
S
N
A
S
C
T
T
N
C
L
A
P
L
A
K
V
I
H
E
R
F
G
I
V
E
G
L
M
T
T
V
H
S
Y
T
A
T
Q
K
T
V
D
G
P
S
R
--
K
A
W
R
D
G
R
G
A
H
Q
N
I
I
P
A
S
T
G
A
A
K
A
V
T
K
V
I
P
E
L
K
G
K
L
T
G
M
A
F
R
V
P
T
P
D
V
S
V
V
D
L
T
C
R
L
A
Q
P
-
A
P
Y
S
A
I
K
E
A
V
K
A
A
A
K
-------
G
P
M
A
G
I
L
A
Y
T
E
D
E
V
V
S
T
D
F
L
G
D
T
H
S
S
I
F
D
A
K
A
G
I
A
L
N
D
-
N
-
F
V
K
L
I
S
W
Y
D
N
E
Y
G
Y
S
H
R
V
V
D
L
L
R
Y
M
F
S
R
84
PsiBlast_CBE
86.53
40%
-99
- C4 -
1DC6
1
G3P1_ECOLI
B:
[2-324]
I
K
V
G
I
N
G
F
G
R
I
G
R
I
V
F
R
A
A
Q
K
R
S
D
-------
I
E
I
V
A
I
N
D
L
-
L
-
D
A
D
Y
M
A
Y
M
L
K
Y
D
S
T
H
G
R
F
-------
D
G
-
T
V
E
V
K
-
D
G
H
L
I
V
N
G
K
K
I
R
V
TAERDP
A
N
--
L
-------
K
----
W
------
D
----
E
V
-------
G
V
D
V
V
A
E
A
T
G
L
F
L
T
D
E
T
A
R
K
H
I
T
A
G
A
K
K
V
V
M
T
G
P
-----
S
K
D
N
T
P
M
F
V
K
G
A
N
F
-
D
K
Y
--
A
--
G
--
Q
D
--
I
V
S
N
A
S
C
T
T
N
C
L
A
P
L
A
K
V
I
N
D
N
F
G
I
I
E
G
L
M
T
T
V
H
A
T
T
A
T
Q
K
T
V
D
G
P
S
H
--
K
D
W
R
G
G
R
G
A
S
Q
N
I
I
P
S
S
T
G
A
A
K
A
V
G
K
V
L
P
E
L
N
G
K
L
T
G
M
A
F
R
V
P
T
P
N
V
S
V
V
D
L
T
V
R
L
E
K
A
-
A
T
Y
E
Q
I
K
A
A
V
K
A
A
A
E
-------
G
E
M
K
G
V
L
G
Y
T
E
D
D
V
V
S
T
D
F
N
G
E
V
C
T
S
V
F
D
A
K
A
G
I
A
L
N
D
-
N
-
F
V
K
L
V
S
W
Y
D
N
E
T
G
Y
S
N
K
V
L
D
L
I
A
H
I
S
K
-
123
HHSearch
86.45
42%
-100
- C4 -
2EP7
1
G3P_AQUAE
A:
[3-339]
I
K
V
G
I
N
G
F
G
R
I
G
R
S
F
F
R
A
S
W
G
----
R
E
---
E
I
E
I
V
A
I
N
D
L
-
T
-
D
A
K
H
L
A
H
L
L
K
Y
D
S
V
H
G
I
F
-------
K
G
-
S
V
E
A
K
-
D
D
S
I
V
V
D
G
K
E
I
K
V
------
F
A
--
Q
KD-----
P
SQIP
W
------
G
----
D
L
-------
G
V
D
V
V
I
E
A
T
G
V
F
R
D
R
E
N
A
S
K
H
L
Q
G
G
A
K
K
V
I
I
T
A
P
A
K
N
-----
P
D
I
T
V
V
L
G
V
N
E
-
E
K
Y
--
N
PK
E
--
H
N
--
I
I
S
N
A
S
C
T
T
N
C
L
A
P
C
V
K
V
L
N
E
A
F
G
V
E
K
G
Y
M
V
T
V
H
A
Y
T
N
D
Q
R
L
L
D
L
P
H
---
K
D
F
R
R
A
R
A
A
A
I
N
I
V
P
T
T
T
G
A
A
K
A
I
G
E
V
I
P
E
L
K
G
K
L
D
G
T
A
R
R
V
P
V
P
D
G
S
L
I
D
L
T
V
V
V
N
K
A
P
S
S
V
E
E
V
N
E
K
F
R
E
A
A
Q
K
Y
R
E
SGK
V
Y
L
K
E
I
L
Q
Y
C
E
D
P
I
V
S
T
D
I
V
G
N
P
H
S
A
I
F
D
A
P
L
T
Q
V
I
-
D
-
N
-
L
V
H
I
A
A
W
Y
D
N
E
W
G
Y
S
C
R
L
R
D
L
V
I
Y
L
A
E
R
85
PsiBlast_CBE
86.33
40%
-96
- C4 -
1DC6
1
G3P1_ECOLI
A:
[2-324]
I
K
V
G
I
N
G
F
G
R
I
G
R
I
V
F
R
A
A
Q
K
R
S
D
-------
I
E
I
V
A
I
N
D
L
-
L
-
D
A
D
Y
M
A
Y
M
L
K
Y
D
S
T
H
G
R
F
-------
D
G
-
T
V
E
V
K
-
D
G
H
L
I
V
N
G
K
K
I
R
V
T
AERDP
A
N
--
L
-------
K
----
W
------
D
----
E
V
-------
G
V
D
V
V
A
E
A
T
G
L
F
L
T
D
E
T
A
R
K
H
I
T
A
G
A
K
K
V
V
M
T
G
P
-----
S
K
D
N
T
P
M
F
V
K
G
A
N
F
-
D
K
Y
--
A
--
G
--
Q
D
--
I
V
S
N
A
S
C
T
T
N
C
L
A
P
L
A
K
V
I
N
D
N
F
G
I
I
E
G
L
M
T
T
V
H
A
T
T
A
T
Q
K
T
V
D
G
P
S
H
--
K
D
W
R
G
G
R
G
A
S
Q
N
I
I
P
S
S
T
G
A
A
K
A
V
G
K
V
L
P
E
L
N
G
K
L
T
G
M
A
F
R
V
P
T
P
N
V
S
V
V
D
L
T
V
R
L
E
K
A
-
A
T
Y
E
Q
I
K
A
A
V
K
A
A
A
E
-------
G
E
M
K
G
V
L
G
Y
T
E
D
D
V
V
S
T
D
F
N
G
E
V
C
T
S
V
F
D
A
K
A
G
I
A
L
N
D
-
N
-
F
V
K
L
V
S
W
Y
D
N
E
T
G
Y
S
N
K
V
L
D
L
I
A
H
I
S
K
-
69
PsiBlast_CBE
86.05
41%
-99
- C4 -
4BOY
1
?
A:
[19-349]
V
R
V
A
I
N
G
F
G
R
I
G
R
N
F
M
R
C
W
L
Q
R
K
-
A
N
S
---
K
L
E
I
V
G
I
N
D
T
-
S
-
D
P
R
T
N
A
H
L
L
K
Y
D
S
M
L
G
I
F
QD
A
E
I
T
A
D
D
-
D
C
I
Y
A
-
G
G
H
A
V
K
C
V
S
D
R
N
P
------
E
N
--
L
-------
P
----
W
------
S
----
A
W
-------
G
I
D
L
V
I
E
A
T
G
V
F
T
S
R
E
G
A
S
K
H
L
S
A
G
A
K
K
V
L
I
T
A
P
G
K
G
-----
N
I
P
T
Y
V
V
G
V
N
H
-
H
T
Y
--
D
P-
S
--
E
D
--
I
V
S
N
A
S
C
T
T
N
C
L
A
P
I
V
K
V
L
H
E
A
F
G
I
Q
Q
G
M
M
T
T
T
H
S
Y
T
G
D
Q
R
L
L
D
A
S
H
---
R
D
L
R
R
A
R
A
A
A
M
N
I
V
P
T
S
T
G
A
A
K
A
V
G
L
V
I
P
E
L
Q
G
K
L
N
G
I
A
L
R
V
P
T
P
N
V
S
V
V
D
F
V
A
Q
V
E
K
P
-
T
I
A
E
Q
V
N
Q
V
I
K
E
A
S
E
-------
T
T
M
K
G
I
I
H
Y
S
E
L
E
L
V
S
S
D
Y
R
G
H
N
A
S
S
I
L
D
A
S
L
T
M
V
L
G
G
-
N
-
L
V
K
V
V
A
W
Y
D
N
E
W
G
Y
S
Q
R
V
L
D
L
A
E
H
M
A
A
H
19
PsiBlast_PDB
85.90
41%
-100
- C4 -
3ZCX
1
?
A:
[19-349]
V
R
V
A
I
N
G
F
G
R
I
G
R
N
F
M
R
C
W
L
Q
R
K
-
A
N
S
---
K
L
E
I
V
G
I
N
D
T
-
S
-
D
P
R
T
N
A
H
L
L
K
Y
D
S
M
L
G
I
F
QD
A
E
I
T
A
D
D
-
D
C
I
Y
A
-
G
G
H
A
V
K
C
V
S
D
R
N
P
------
E
N
--
L
-------
P
----
W
------
S
----
A
W
-------
G
I
D
L
V
I
E
A
T
G
V
F
T
S
R
E
G
A
S
K
H
L
S
A
G
A
K
K
V
L
I
T
A
P
G
K
G
-----
N
I
P
T
Y
V
V
G
V
N
H
-
H
T
Y
--
D
P-
S
--
E
D
--
I
V
S
N
A
S
C
T
T
N
C
L
A
P
I
V
K
V
L
H
E
A
F
G
I
Q
Q
G
M
M
T
T
T
H
S
Y
T
G
D
Q
R
L
L
D
A
S
H
---
R
D
L
R
R
A
R
A
A
A
M
N
I
V
P
T
S
T
G
A
A
K
A
V
G
L
V
I
P
E
L
Q
G
K
L
N
G
I
A
L
R
V
P
T
P
N
V
S
V
V
D
F
V
A
Q
V
E
K
P
-
T
I
A
E
Q
V
N
Q
V
I
K
E
A
S
E
-------
T
T
M
K
G
I
I
H
Y
S
E
L
E
L
V
S
S
D
Y
R
G
H
N
A
S
S
I
L
D
A
S
L
T
M
V
L
G
G
-
N
-
L
V
K
V
V
A
W
Y
D
N
E
W
G
Y
S
Q
R
V
L
D
L
A
E
H
M
A
A
H
65
PsiBlast_CBE
85.59
41%
-101
- C4 -
3L0D
1
?
B:
[24-349]
V
R
V
A
I
N
G
F
G
R
I
G
R
N
I
L
R
A
I
I
E
S
G
R
Q
D
-----
I
E
V
V
A
L
N
D
L
-
G
-
S
V
E
T
N
A
H
L
L
R
Y
D
S
V
H
G
C
F
-------
P
G
-
T
V
Q
V
V
-
G
D
A
I
D
I
---
L
I
K
V
------
F
A
--
E
-------
R
----
D
------
P
----
A
Q
LPWKAL-
D
I
D
I
A
L
E
C
T
G
I
F
T
A
R
D
K
A
S
A
H
L
D
A
G
A
K
R
V
L
V
S
A
P
-----
S
E
G
A
D
L
T
V
V
Y
G
V
N
H
Q
F
L
S
--
K
--
E
--
H
H
--
V
I
S
N
A
S
C
T
T
N
C
L
A
P
V
A
Q
V
L
H
N
T
V
G
I
E
K
G
F
M
T
T
I
H
S
Y
T
G
D
Q
P
V
L
D
T
M
H
---
R
D
L
Y
R
A
R
A
A
A
L
S
M
I
P
T
S
T
G
A
A
K
A
V
G
L
V
L
P
E
L
K
G
L
L
D
G
V
S
I
R
V
P
T
P
N
V
S
V
V
D
L
T
F
T
A
K
R
S
-
T
T
I
E
E
I
N
T
A
I
R
T
A
A
Q
-------
G
S
L
K
G
I
L
D
Y
T
D
E
K
L
V
S
C
D
F
N
H
N
P
H
S
A
I
F
H
N
D
Q
T
K
V
I
-
D
G
Q
-
L
C
R
V
L
V
W
Y
D
N
E
W
G
F
S
N
R
M
C
D
T
A
V
A
F
A
K
T
20
PsiBlast_PDB
85.58
41%
-99
- C4 -
3ZDF
2
?
A:
[19-349]
V
R
V
A
I
N
G
F
G
R
I
G
R
N
F
M
R
C
W
L
Q
R
K
-
A
N
S
---
K
L
E
I
V
G
I
N
D
T
-
S
-
D
P
R
T
N
A
H
L
L
K
Y
D
S
M
L
G
I
F
QD
A
E
I
T
A
D
D
-
D
C
I
Y
A
-
G
G
H
A
V
K
C
V
S
D
R
N
P
------
E
N
--
L
-------
P
----
W
------
S
----
A
W
-------
G
I
D
L
V
I
E
A
T
G
V
F
T
S
R
E
G
A
S
K
H
L
S
A
G
A
K
K
V
L
I
T
A
P
G
K
G
-----
N
I
P
T
Y
V
V
G
V
N
H
-
H
T
Y
--
D
P-
S
--
E
D
--
I
V
S
N
A
S
C
T
T
N
C
L
A
P
I
V
K
V
L
H
E
A
F
G
I
Q
Q
G
M
M
T
T
T
H
S
Y
T
G
D
Q
R
L
L
D
A
S
H
---
R
D
L
R
R
A
R
A
A
A
M
N
I
V
P
T
S
T
G
A
A
K
A
V
G
L
V
I
P
E
L
Q
G
K
L
N
G
I
A
L
R
V
P
T
P
N
V
S
V
V
D
F
V
A
Q
V
E
K
P
-
T
I
A
E
Q
V
N
Q
V
I
K
E
A
S
E
-------
T
T
M
K
G
I
I
H
Y
S
E
L
E
L
V
S
S
D
Y
R
G
H
N
A
S
S
I
L
D
A
S
L
T
M
V
L
G
G
-
N
-
L
V
K
V
V
A
W
Y
D
N
E
W
G
Y
S
Q
R
V
L
D
L
A
E
H
M
A
A
H
71
PsiBlast_CBE
85.01
41%
-99
- C4 -
3ZCX
1
?
B:
[19-349]
V
R
V
A
I
N
G
F
G
R
I
G
R
N
F
M
R
C
W
L
Q
R
K
-
A
N
S
---
K
L
E
I
V
G
I
N
D
T
-
S
-
D
P
R
T
N
A
H
L
L
K
Y
D
S
M
L
G
I
F
QDAEITA
D
D
-
D
C
I
Y
A
-
G
G
H
A
V
K
C
V
S
D
R
N
P
------
E
N
--
L
-------
P
----
W
------
S
----
A
W
-------
G
I
D
L
V
I
E
A
T
G
V
F
T
S
R
E
G
A
S
K
H
L
S
A
G
A
K
K
V
L
I
T
A
P
G
K
G
-----
N
I
P
T
Y
V
V
G
V
N
H
-
H
T
Y
--
D
P-
S
--
E
D
--
I
V
S
N
A
S
C
T
T
N
C
L
A
P
I
V
K
V
L
H
E
A
F
G
I
Q
Q
G
M
M
T
T
T
H
S
Y
T
G
D
Q
R
L
L
D
A
S
H
---
R
D
L
R
R
A
R
A
A
A
M
N
I
V
P
T
S
T
G
A
A
K
A
V
G
L
V
I
P
E
L
Q
G
K
L
N
G
I
A
L
R
V
P
T
P
N
V
S
V
V
D
F
V
A
Q
V
E
K
P
-
T
I
A
E
Q
V
N
Q
V
I
K
E
A
S
E
-------
T
T
M
K
G
I
I
H
Y
S
E
L
E
L
V
S
S
D
Y
R
G
H
N
A
S
S
I
L
D
A
S
L
T
M
V
L
G
G
-
N
-
L
V
K
V
V
A
W
Y
D
N
E
W
G
Y
S
Q
R
V
L
D
L
A
E
H
M
A
A
H
68
PsiBlast_CBE
84.98
41%
-98
- C4 -
4BOY
1
?
B:
[19-349]
V
R
V
A
I
N
G
F
G
R
I
G
R
N
F
M
R
C
W
L
Q
R
K
-
A
N
S
---
K
L
E
I
V
G
I
N
D
T
-
S
-
D
P
R
T
N
A
H
L
L
K
Y
D
S
M
L
G
I
F
QDAEITA
D
D
-
D
C
I
Y
A
-
G
G
H
A
V
K
C
V
S
D
R
N
P
------
E
N
--
L
-------
P
----
W
------
S
----
A
W
-------
G
I
D
L
V
I
E
A
T
G
V
F
T
S
R
E
G
A
S
K
H
L
S
A
G
A
K
K
V
L
I
T
A
P
G
K
G
-----
N
I
P
T
Y
V
V
G
V
N
H
-
H
T
Y
--
D
P-
S
--
E
D
--
I
V
S
N
A
S
C
T
T
N
C
L
A
P
I
V
K
V
L
H
E
A
F
G
I
Q
Q
G
M
M
T
T
T
H
S
Y
T
G
D
Q
R
L
L
D
A
S
H
---
R
D
L
R
R
A
R
A
A
A
M
N
I
V
P
T
S
T
G
A
A
K
A
V
G
L
V
I
P
E
L
Q
G
K
L
N
G
I
A
L
R
V
P
T
P
N
V
S
V
V
D
F
V
A
Q
V
E
K
P
-
T
I
A
E
Q
V
N
Q
V
I
K
E
A
S
E
-------
T
T
M
K
G
I
I
H
Y
S
E
L
E
L
V
S
S
D
Y
R
G
H
N
A
S
S
I
L
D
A
S
L
T
M
V
L
G
G
-
N
-
L
V
K
V
V
A
W
Y
D
N
E
W
G
Y
S
Q
R
V
L
D
L
A
E
H
M
A
A
H
15
PsiBlast_PDB
83.89
41%
-98
- C4 -
3L0D
1
?
A:
[24-349]
V
R
V
A
I
N
G
F
G
R
I
G
R
N
I
L
R
A
I
I
E
S
G
R
Q
D
-----
I
E
V
V
A
L
N
D
L
-
G
-
S
V
E
T
N
A
H
L
L
R
Y
D
S
V
H
G
C
F
-------
P
G
-
T
V
Q
V
V
-
G
D
A
I
D
I
---
L
I
K
V
------
F
A
--
E
-------
R
----
D
------
P
----
A
Q
LPWKAL-
D
I
D
I
A
L
E
C
T
G
I
F
T
A
R
D
K
A
S
A
H
L
D
A
G
A
K
R
V
L
V
S
A
P
-----
S
E
G
A
D
L
T
V
V
Y
G
V
N
H
Q
F
L
S
--
K
--
E
--
H
H
--
V
I
S
N
A
S
C
T
T
N
C
L
A
P
V
A
Q
V
L
H
N
T
V
G
I
E
K
G
F
M
T
T
I
H
S
Y
T
G
D
Q
P
V
L
D
T
M
H
---
R
D
L
Y
R
A
R
A
A
A
L
S
M
I
P
T
S
T
G
A
A
K
A
V
G
L
V
L
P
E
L
K
G
L
L
D
G
V
S
I
R
V
P
T
P
N
V
S
V
V
D
L
T
F
T
A
K
R
S
-
T
T
I
E
E
I
N
T
A
I
R
T
A
A
Q
-------
G
S
L
K
G
I
L
D
Y
T
D
E
K
L
V
S
C
D
F
N
H
N
P
H
S
A
I
F
H
N
D
Q
T
K
V
I
-
D
G
Q
-
L
C
R
V
L
V
W
Y
D
N
E
W
G
F
S
N
R
M
C
D
T
A
V
A
F
A
K
T
18
PsiBlast_PDB
78.51
40%
-105
- C4 -
1GPD
2
G3P_HOMAM
G:
[2-327]
-
K
I
G
I
N
G
F
G
R
I
G
R
L
V
L
R
A
A
L
S
C
G
--------
A
Q
V
V
A
V
N
D
P
F
I
-
A
L
E
Y
M
V
Y
M
F
K
Y
D
S
T
H
G
V
F
-------
K
G
-
E
V
K
M
E
-
D
G
A
L
V
V
D
G
K
K
I
T
V
------
F
N
--
E
-------
M
----
K
PENIPW
S
----
K
A
-------
G
A
E
Y
I
V
E
S
T
G
V
F
T
T
I
E
K
A
S
A
H
F
K
G
G
A
K
K
V
V
I
S
A
P
------
S
A
D
A
P
M
F
V
C
G
V
N
L
-
E
K
Y
S-
K
--
D
--
M
T
--
V
V
S
N
A
S
C
T
T
N
C
L
A
P
V
A
K
V
L
H
E
N
F
E
I
V
E
G
L
M
T
T
V
H
A
V
T
A
T
Q
K
T
V
D
G
P
S
A
--
K
D
W
R
G
G
R
G
A
A
Q
N
I
I
P
S
S
T
G
A
A
K
A
V
G
K
V
I
P
E
L
D
G
K
L
T
G
M
A
F
R
V
P
T
P
D
V
S
V
V
D
L
T
V
R
L
G
K
E
-
C
S
Y
D
D
I
K
A
A
M
K
T
A
S
E
-------
G
P
L
Q
G
F
L
G
Y
T
E
D
D
V
V
S
S
D
F
I
G
D
N
R
S
S
I
F
D
A
K
A
G
I
Q
L
S
K
-
T
-
F
V
K
V
V
S
W
Y
D
N
E
F
G
Y
S
Q
R
V
I
D
L
L
K
H
M
Q
K
V
67
PsiBlast_CBE
73.81
40%
-95
- C4 -
1GPD
4
G3P_HOMAM
R:
[2-327]
-
K
I
G
I
N
G
F
G
R
I
G
R
L
V
L
R
A
A
L
S
C
G
--------
A
Q
V
V
A
V
N
D
P
F
I
-
A
L
E
Y
M
V
Y
M
F
K
Y
D
S
T
H
G
V
F
-------
K
G
-
E
V
K
M
E
-
D
G
A
L
V
V
D
G
K
K
I
T
V
------
F
N
--
E
-------
M
----
K
PENIPW
S
----
K
A
-------
G
A
E
Y
I
V
E
S
T
G
V
F
T
T
I
E
K
A
S
A
H
F
K
G
G
A
K
K
V
V
I
S
A
P
------
S
A
D
A
P
M
F
V
C
G
V
N
L
-
E
K
Y
S-
K
--
D
--
M
T
--
V
V
S
N
A
S
C
T
T
N
C
L
A
P
V
A
K
V
L
H
E
N
F
E
I
V
E
G
L
M
T
T
V
H
A
V
T
A
T
Q
K
T
V
D
G
P
S
A
--
K
D
W
R
G
G
R
G
A
A
Q
N
I
I
P
S
S
T
G
A
A
K
A
V
G
K
V
I
P
E
L
D
G
K
L
T
G
M
A
F
R
V
P
T
P
D
V
S
V
V
D
L
T
V
R
L
G
K
E
-
C
S
Y
D
D
I
K
A
A
M
K
T
A
S
E
-------
G
P
L
Q
G
F
L
G
Y
T
E
D
D
V
V
S
S
D
F
I
G
D
N
R
S
S
I
F
D
A
K
A
G
I
Q
L
S
K
-
T
-
F
V
K
V
V
S
W
Y
D
N
E
F
G
Y
S
Q
R
V
I
D
L
L
K
H
M
Q
K
V