@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_0895: (2015-12-19 )
MEIAVFGGGAWGRALAFAFGEKNEVKIISRRDLNEPLKKLNDALISKGSAPIEQVDLERGLKAALYVIAISVQHLREWFQNASLPKNAKVLIASKGIEVLNKAFVSEIAKDFIDPNALCFLAGPSFAAEIIQGLPCALVIHSNNQALALEFANKTPSFIRAYAQQDIIGGEIAGAYKNVIAIAGGVCDGLKLGNSAKASLLSRGLVEMQRFGAFFGGKTETFLGLSGAGDLFLTANSILSRNYRVGLGLAQNKPLEVVLEELGEVAEGVKTTNAIVEIARKYGIYTPIASELALLLKGKSVLESMNDLIRRA
Atome Classification :
(20 SA)
-------.........10........20------..-.-------.-...--..-30.--..-----...---------..--40------.------.---.-....---.-50----....--------....-60...-.-----....70........80-.-------.-------.----.---------------------.-....90..------......--100.--...--.....110..--------.--....120----------........130.......140.......150---..--.---.-.--.-..160.......170.......180.......------190.-----......200.......210.....---.---.220.......230.......240.......250.---.......260---.--..----.....270.......280.--.--.....290-....-...300........310-----------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-------
M
E
I
A
V
FGGG
A
W
G
R
A
L
A
FAFG-------EK-N-------
E
-
V
K
I
--
I
S
-
R
R
D
--
L
N
-----
E
P
L
---------
K
K
--
L
N
------
D
------
A
---
L
-ISKG---S-A
P
----
I
E
Q
V
--------
D
L
E
R
-
G
L
K
A
A
-
L
-----
Y
V
I
A
I
S
V
Q
H
L
R
E
W
F
Q
--N-------A-------S----L---------------------P-KN
A
K
V
L
I
A------SK
G
I
E
V
--
L
--
N
--
K
A
F
--
V
S
E
I
A
K
D
FID--------P--N
A
L
C
F
L-----------AG
P
S
F
A
A
E
I
IQGL
P
C
A
L
V
I
HSNN
Q
A
L
A
L
E
F----AN--K---
T
-
P
--
S
-
F
I
R
A
Y
A
Q
QDIIG
G
E
I
A
G
A
Y
K
N
V
I
A
IAGGVCDG------LKLG-----
N
S
A
K
A
S
L
L
S
R
G
L
V
E
M
Q
R
F
G
A
F
FGG---K---
T
E
T
F
L
GLSGAG
D
L
F
L
T
A
N
S
I
LSRN
Y
R
V
G
LGLAQ-N---K
P
L
E
V
V
L
E
E
----
L
--
G
E
----
V
A
E
G
VK
T
T
N
A
I
V
E
I
A
R
KYG--I--YTP
I
A
S
E
L
-
A
L
L
L-K
G
K
S
V
-
L
E
S
M
N
D
L
IRRA-----------
1
PsiBlast_PDB
95.18
39%
-91
- C1 -
1Z82
7
?
A:
[19-325]
-----------
V
L
G
A
G
S
W
G
T
V
F
A
Q
M
L
H
-------
E
N
G
E
-------
E
-
V
I
L
--
W
A
-
R
R
----------------------
K
E
--
I
V
------
D
------
L
---
I
N
V
S
H
T
---
S
-
P
Y
----
V
E
E
S
KITVRATN
D
L
E
E
-
I
K
K
E
D
-
I
-----
L
V
I
A
I
P
V
Q
Y
I
R
E
H
L
-----------
L
-------
R
----
L
---------------------
P
V
K
P
S
M
V
L
N
L
------
S
K
G
I
E
I
--
K
--
T
--
G
K
R
--
V
S
E
I
V
E
E
I
L
G
C
-------
P
--
Y
A
V
--
L
-----------
S
G
P
S
H
A
E
E
V
A
K
K
L
P
T
A
V
T
L
A
G
E
N
S
K
---
E
L
----
Q
K
--
R
I
--
S
-
T
--
E
-
Y
F
R
V
Y
T
C
E
D
V
V
G
V
E
I
A
G
A
L
K
N
V
I
A
I
A
A
G
I
L
D
G
------
F
G
G
W
-----
D
N
A
K
A
A
L
E
T
R
G
I
Y
E
I
A
R
F
G
M
F
F
G
A
---
D
---
Q
K
T
F
M
G
L
A
G
I
G
D
L
M
V
T
C
N
S
R
Y
S
R
N
R
R
F
G
E
L
I
A
R
-
G
F--
N
P
L
K
-
L
L
E
S
----
S
--
N
Q
----
V
V
E
G
A
F
T
V
K
A
V
M
K
I
A
K
E
N
K
--
I
--
D
M
P
I
S
E
E
V
Y
R
V
V
Y
-
E
G
K
P
P
-
L
Q
S
M
R
D
L
M
R
-------------
21
PsiBlast_CBE
91.00
32%
-101
- C1 -
1N1E
1
GPDA_LEIME
B:
[20-343]
-----------
V
F
G
S
G
A
F
G
T
A
L
A
M
V
L
S
-------
K
K
C
R
-------
E
-
V
C
V
WH
M
N
-
E
E
E
--
V
R
-----
L
V
N
---------
E
K
--
R
E
------
N
------
V
---
L
-
F
L
K
G
---
V
-
Q
L
----
A
S
N
I
TFTS----
D
V
E
K
-
A
Y
N
G
A
E
I
-----
I
L
F
V
I
P
T
Q
F
L
R
G
F
F
E
--
K
-------
S
GGNLIAY
A
----
K
---------------------
E
-
K
Q
V
P
V
L
V
C
------
T
K
G
I
E
R
--
S
--
T
--
L
K
F
--
P
A
E
I
I
G
E
F
L
P
--------
S
--
P
L
L
S
V
L
-----------
A
G
P
S
F
A
I
E
V
A
T
G
V
F
T
C
V
S
I
A
S
A
D
I
N
V
A
R
R
L
QRIM
S
T
--
G
---
D
-
R
--
S
-
F
V
-
C
W
A
T
T
D
T
V
G
C
E
V
A
S
A
V
K
N
V
L
A
I
G
S
G
V
A
N
G
------
L
G
M
G
-----
L
N
A
R
A
A
L
I
M
R
G
L
L
E
I
R
D
L
T
A
A
L
G
G
---
D
---
G
S
A
V
F
G
L
A
G
L
G
D
L
Q
L
T
C
S
S
E
L
S
R
N
F
T
V
G
K
K
L
G
K
-
G
---
L
P
I
E
E
I
Q
R
T
----
S
--
K
A
----
V
A
E
G
V
A
T
A
D
P
L
M
R
L
A
K
Q
L
K
--
V
--
K
M
P
L
C
H
Q
I
Y
E
I
V
Y
-
K
K
K
N
P
-
R
D
A
L
A
D
L
L
S
C
G
-----------
5
PsiBlast_PDB
90.71
32%
-105
- C1 -
1M66
2
GPDA_LEIME
A:
[20-343]
-----------
V
F
G
S
G
A
F
G
T
A
L
A
M
V
L
S
-------
K
K
C
R
-------
E
-
V
C
V
W
H
M
N
-
E
E
E
--
V
R
-----
L
V
N
---------
E
K
--
R
E
------
N
------
V
---
L
-
F
L
K
G
---
V
-
Q
L
----
A
S
N
I
T
F
T
S----
D
V
E
K
-
A
Y
N
G
A
E
I
-----
I
L
F
V
I
P
T
Q
F
L
R
G
F
F
E
--
K
-------
S
G
G
N
L
I
A
Y
A
----
K
---------------------
E
-
K
Q
V
P
V
L
V
C
------
T
K
G
I
E
R
--
S
--
T
--
L
K
F
--
P
A
E
I
I
G
E
F
L
P
--------
S
--
P
L
L
S
V
L
-----------
A
G
P
S
F
A
I
E
V
A
T
G
V
F
T
C
V
S
I
A
S
A
D
I
N
V
A
R
R
L
Q
R
I
M
S
T
--
G
---
D
-
R
--
S
-
F
V
-
C
W
A
T
T
D
T
V
G
C
E
V
A
S
A
V
K
N
V
L
A
I
G
S
G
V
A
N
G
------
L
G
M
G
-----
L
N
A
R
A
A
L
I
M
R
G
L
L
E
I
R
D
L
T
A
A
L
G
G
---
D
---
G
S
A
V
F
G
L
A
G
L
G
D
L
Q
L
T
C
S
S
E
L
S
R
N
F
T
V
G
K
K
L
G
K
-
G
---
L
P
I
E
E
I
Q
R
---------
A
----
V
A
E
G
V
A
T
A
D
P
L
M
R
L
A
K
Q
L
K
--
V
--
K
M
P
L
C
H
Q
I
Y
E
I
V
Y
-
K
K
K
N
P
-
R
D
A
L
A
D
L
L
S
C
G
-----------
2
PsiBlast_PDB
90.65
32%
-109
- C1 -
1EVY
1
GPDA_LEIME
A:
[20-343]
-----------
V
F
G
S
G
A
F
G
T
A
L
A
M
V
L
S
-------
K
K
C
R
-------
E
-
V
C
V
W
H
M
N
-
E
E
E
--
V
R
-----
L
V
N
---------
E
K
--
R
E
------
N
------
V
---
L
-
F
L
K
G
---
V
-
Q
L
----
A
S
N
I
T
F
T
S----
D
V
E
K
-
A
Y
N
G
A
E
I
-----
I
L
F
V
I
P
T
Q
F
L
R
G
F
F
E
--
K
-------
S
G
G
N
L
I
A
Y
A
----
K
---------------------
E
-
K
Q
V
P
V
L
V
C
------
T
K
G
I
E
R
--
S
--
T
--
L
K
F
--
P
A
E
I
I
G
E
F
L
P
--------
S
--
P
L
L
S
V
L
-----------
A
G
P
S
F
A
I
E
V
A
T
G
V
F
T
C
V
S
I
A
S
A
D
I
N
V
A
R
R
L
Q
R
I
M
S
T
--
G
---
D
-
R
--
S
-
F
V
-
C
W
A
T
T
D
T
V
G
C
E
V
A
S
A
V
K
N
V
L
A
I
G
S
G
V
A
N
G
------
L
G
M
G
-----
L
N
A
R
A
A
L
I
M
R
G
L
L
E
I
R
D
L
T
A
A
L
G
G
---
D
---
G
S
A
V
F
G
L
A
G
L
G
D
L
Q
L
T
C
S
S
E
L
S
R
N
F
T
V
G
K
K
L
G
K
-
G
---
L
P
I
E
E
I
Q
R
---------
A
----
V
A
E
G
V
A
T
A
D
P
L
M
R
L
A
K
Q
L
K
--
V
--
K
M
P
L
C
H
Q
I
Y
E
I
V
Y
-
K
K
K
N
P
-
R
D
A
L
A
D
L
L
S
C
G
-----------
8
PsiBlast_PDB
90.59
32%
-104
- C1 -
1N1G
3
GPDA_LEIME
A:
[20-343]
-----------
V
F
G
S
G
A
F
G
T
A
L
A
M
V
L
S
-------
K
K
C
R
-------
E
-
V
C
V
W
H
M
N
-
E
E
E
--
V
R
-----
L
V
N
---------
E
K
--
R
E
------
N
------
V
---
L
-
F
L
K
G
---
V
-
Q
L
----
A
S
N
I
T
F
T
S----
D
V
E
K
-
A
Y
N
G
A
E
I
-----
I
L
F
V
I
P
T
Q
F
L
R
G
F
F
E
--
K
-------
S
G
G
N
L
I
A
Y
A
----
K
---------------------
E
-
K
Q
V
P
V
L
V
C
------
T
K
G
I
E
R
--
S
--
T
--
L
K
F
--
P
A
E
I
I
G
E
F
L
P
--------
S
--
P
L
L
S
V
L
-----------
A
G
P
S
F
A
I
E
V
A
T
G
V
F
T
C
V
S
I
A
S
A
D
I
N
V
A
R
R
L
Q
R
I
M
S
T
--
G
---
D
-
R
--
S
-
F
V
-
C
W
A
T
T
D
T
V
G
C
E
V
A
S
A
V
K
N
V
L
A
I
G
S
G
V
A
N
G
------
L
G
M
G
-----
L
N
A
R
A
A
L
I
M
R
G
L
L
E
I
R
D
L
T
A
A
L
G
G
---
D
---
G
S
A
V
F
G
L
A
G
L
G
D
L
Q
L
T
C
S
S
E
L
S
R
N
F
T
V
G
K
K
L
G
K
-
G
---
L
P
I
E
E
I
Q
R
---------
A
----
V
A
E
G
V
A
T
A
D
P
L
M
R
L
A
K
Q
L
K
--
V
--
K
M
P
L
C
H
Q
I
Y
E
I
V
Y
-
K
K
K
N
P
-
R
D
A
L
A
D
L
L
S
C
G
-----------
3
PsiBlast_PDB
90.45
32%
-108
- C1 -
1EVZ
2
GPDA_LEIME
A:
[20-343]
-----------
V
F
G
S
G
A
F
G
T
A
L
A
M
V
L
S
-------
K
K
C
R
-------
E
-
V
C
V
W
H
M
N
-
E
E
E
--
V
R
-----
L
V
N
---------
E
K
--
R
E
------
N
------
V
---
L
-
F
L
K
G
---
V
-
Q
L
----
A
S
N
I
T
F
T
S----
D
V
E
K
-
A
Y
N
G
A
E
I
-----
I
L
F
V
I
P
T
Q
F
L
R
G
F
F
E
--
K
-------
S
G
G
N
L
I
A
Y
A
----
K
---------------------
E
-
K
Q
V
P
V
L
V
C
------
T
K
G
I
E
R
--
S
--
T
--
L
K
F
--
P
A
E
I
I
G
E
F
L
P
--------
S
--
P
L
L
S
V
L
-----------
A
G
P
S
F
A
I
E
V
A
T
G
V
F
T
C
V
S
I
A
S
A
D
I
N
V
A
R
R
L
Q
R
I
M
S
T
--
G
---
D
-
R
--
S
-
F
V
-
C
W
A
T
T
D
T
V
G
C
E
V
A
S
A
V
K
N
V
L
A
I
G
S
G
V
A
N
G
------
L
G
M
G
-----
L
N
A
R
A
A
L
I
M
R
G
L
L
E
I
R
D
L
T
A
A
L
G
G
---
D
---
G
S
A
V
F
G
L
A
G
L
G
D
L
Q
L
T
C
S
S
E
L
S
R
N
F
T
V
G
K
K
L
G
K
-
G
---
L
P
I
E
E
I
Q
R
---------
A
----
V
A
E
G
V
A
T
A
D
P
L
M
R
L
A
K
Q
L
K
--
V
--
K
M
P
L
C
H
Q
I
Y
E
I
V
Y
-
K
K
K
N
P
-
R
D
A
L
A
D
L
L
S
C
G
-----------
4
PsiBlast_PDB
89.92
32%
-105
- C1 -
1JDJ
2
GPDA_LEIME
A:
[20-343]
-----------
V
F
G
S
G
A
F
G
T
A
L
A
M
V
L
S
-------
K
K
C
R
-------
E
-
V
C
V
W
H
M
N
-
E
E
E
--
V
R
-----
L
V
N
---------
E
K
--
R
E
------
N
------
V
---
L
-
F
L
K
G
---
V
-
Q
L
----
A
S
N
I
T
F
T
S----
D
V
E
K
-
A
Y
N
G
A
E
I
-----
I
L
F
V
I
P
T
Q
F
L
R
G
F
F
E
--
K
-------
S
G
G
N
L
I
A
Y
A
----
K
---------------------
E
-
K
Q
V
P
V
L
V
C
------
T
K
G
I
E
R
--
S
--
T
--
L
K
F
--
P
A
E
I
I
G
E
F
L
P
--------
S
--
P
L
L
S
V
L
-----------
A
G
P
S
F
A
I
E
V
A
T
G
V
F
T
C
V
S
I
A
S
A
D
I
N
V
A
R
R
L
Q
R
I
M
S
T
--
G
---
D
-
R
--
S
-
F
V
-
C
W
A
T
T
D
T
V
G
C
E
V
A
S
A
V
K
N
V
L
A
I
G
S
G
V
A
N
G
------
L
G
M
G
-----
L
N
A
R
A
A
L
I
M
R
G
L
L
E
I
R
D
L
T
A
A
L
G
G
---
D
---
G
S
A
V
F
G
L
A
G
L
G
D
L
Q
L
T
C
S
S
E
L
S
R
N
F
T
V
G
K
K
L
G
K
-
G
---
L
P
I
E
E
I
Q
R
---------
A
----
V
A
E
G
V
A
T
A
D
P
L
M
R
L
A
K
Q
L
K
--
V
--
K
M
P
L
C
H
Q
I
Y
E
I
V
Y
-
K
K
K
N
P
-
R
D
A
L
A
D
L
L
S
C
G
-----------
6
PsiBlast_PDB
89.91
32%
-105
- C1 -
1M67
2
GPDA_LEIME
A:
[20-343]
-----------
V
F
G
S
G
A
F
G
T
A
L
A
M
V
L
S
-------
K
K
C
R
-------
E
-
V
C
V
W
H
M
N
-
E
E
E
--
V
R
-----
L
V
N
---------
E
K
--
R
E
------
N
------
V
---
L
-
F
L
K
G
---
V
-
Q
L
----
A
S
N
I
T
F
T
S----
D
V
E
K
-
A
Y
N
G
A
E
I
-----
I
L
F
V
I
P
T
Q
F
L
R
G
F
F
E
--
K
-------
S
G
G
N
L
I
A
Y
A
----
K
---------------------
E
-
K
Q
V
P
V
L
V
C
------
T
K
G
I
E
R
--
S
--
T
--
L
K
F
--
P
A
E
I
I
G
E
F
L
P
--------
S
--
P
L
L
S
V
L
-----------
A
G
P
S
F
A
I
E
V
A
T
G
V
F
T
C
V
S
I
A
S
A
D
I
N
V
A
R
R
L
Q
R
I
M
S
T
--
G
---
D
-
R
--
S
-
F
V
-
C
W
A
T
T
D
T
V
G
C
E
V
A
S
A
V
K
N
V
L
A
I
G
S
G
V
A
N
G
------
L
G
M
G
-----
L
N
A
R
A
A
L
I
M
R
G
L
L
E
I
R
D
L
T
A
A
L
G
G
---
D
---
G
S
A
V
F
G
L
A
G
L
G
D
L
Q
L
T
C
S
S
E
L
S
R
N
F
T
V
G
K
K
L
G
K
-
G
---
L
P
I
E
E
I
Q
R
---------
A
----
V
A
E
G
V
A
T
A
D
P
L
M
R
L
A
K
Q
L
K
--
V
--
K
M
P
L
C
H
Q
I
Y
E
I
V
Y
-
K
K
K
N
P
-
R
D
A
L
A
D
L
L
S
C
G
-----------
7
PsiBlast_PDB
89.83
32%
-101
- C1 -
1N1E
1
GPDA_LEIME
A:
[20-343]
-----------
V
F
G
S
G
A
F
G
T
A
L
A
M
V
L
S
-------
K
K
C
R
-------
E
-
V
C
V
W
H
M
N
-
E
E
E
--
V
R
-----
L
V
N
---------
E
K
--
R
E
------
N
------
V
---
L
-
F
L
K
G
---
V
-
Q
L
----
A
S
N
I
T
F
T
S----
D
V
E
K
-
A
Y
N
G
A
E
I
-----
I
L
F
V
I
P
T
Q
F
L
R
G
F
F
E
--
K
-------
S
G
G
N
L
I
A
Y
A
----
K
---------------------
E
-
K
Q
V
P
V
L
V
C
------
T
K
G
I
E
R
--
S
--
T
--
L
K
F
--
P
A
E
I
I
G
E
F
L
P
--------
S
--
P
L
L
S
V
L
-----------
A
G
P
S
F
A
I
E
V
A
T
G
V
F
T
C
V
S
I
A
S
A
D
I
N
V
A
R
R
L
Q
R
I
M
S
T
--
G
---
D
-
R
--
S
-
F
V
-
C
W
A
T
T
D
T
V
G
C
E
V
A
S
A
V
K
N
V
L
A
I
G
S
G
V
A
N
G
------
L
G
M
G
-----
L
N
A
R
A
A
L
I
M
R
G
L
L
E
I
R
D
L
T
A
A
L
G
G
---
D
---
G
S
A
V
F
G
L
A
G
L
G
D
L
Q
L
T
C
S
S
E
L
S
R
N
F
T
V
G
K
K
L
G
K
-
G
---
L
P
I
E
E
I
Q
R
T
----
S
--
K
A
----
V
A
E
G
V
A
T
A
D
P
L
M
R
L
A
K
Q
L
K
--
V
--
K
M
P
L
C
H
Q
I
Y
E
I
V
Y
-
K
K
K
N
P
-
R
D
A
L
A
D
L
L
S
C
G
-----------
28
HHSearch
89.76
38%
-78
- C1 -
1Z82
7
?
A:
[15-324]
-------
M
R
F
F
V
L
G
A
G
S
W
G
T
V
F
A
Q
M
L
H
-------
E
N
-
G
-------
E
E
V
I
L
--
W
A
-
R
R
K
--
E
I
-----
V
D
L
---------
I
N
--
V
S
------
H
------
T
---
S
-
P
Y
V
E
ESK
I
-
T
V
----
R
A
T
N
--------
D
L
E
E
-
I
K
K
E
D
-
I
-----
L
V
I
A
I
P
V
Q
Y
I
R
E
H
L
L
R
-
L
-------
P
----------------------------------
V
-
K
P
S
M
V
L
N
L
------
S
K
G
I
E
I
--
K
--
T
--
G
K
R
--
V
S
E
I
V
E
E
I
L
G
-----------
C
P
Y
A
V
L
-----------
S
G
P
S
H
A
E
E
V
A
K
K
L
P
T
A
V
T
L
A
G
E
N
S
---
K
E
L
----
Q
K
--
R
---
I
S
T
--
E
-
Y
F
R
V
Y
T
C
E
D
V
V
G
V
E
I
A
G
A
L
K
N
V
I
A
I
A
A
G
I
L
D
G
------
F
G
G
W
-----
D
N
A
K
A
A
L
E
T
R
G
I
Y
E
I
A
R
F
G
M
F
F
G
A
---
D
---
Q
K
T
F
M
G
L
A
G
I
G
D
L
M
V
T
C
N
S
R
Y
S
R
N
R
R
F
G
E
L
I
A
R
-
G
---
F
N
P
L
K
L
L
E
S
----
S
--
N
Q
----
V
V
E
G
A
F
T
V
K
A
V
M
K
I
A
K
E
N
K
--
I
--
D
M
P
I
S
E
E
V
-
Y
R
V
V
-
Y
E
G
K
P
P
L
Q
S
M
R
D
L
M
R
-------------
9
PsiBlast_PDB
89.32
31%
-98
- C1 -
3K96
1
GPDA_COXBU
A:
[32-336]
---------
I
A
I
L
G
A
G
S
W
G
T
A
L
A
L
V
L
A
-------
R
K
-
G
-------
Q
K
V
R
L
--
W
S
Y
E
S
D
--
H
V
-----
D
E
M
---------
Q
A
E
G
V
N
------
N
------
R
---
Y
-
L
P
N
Y
---
P
-
F
P
-----
E
T
L
--------
K
A
Y
C
-
D
L
K
A
S
-
L
EGVT
D
I
L
I
V
V
P
S
F
A
F
H
E
V
I
T
--
R
-------
M
-------
K
----
P
---------------------
L
-
I
D
A
K
T
R
I
A
W
G
T
K
G
L
A
K
G
S
R
L
--
L
--
H
--
E
V
V
--
A
T
E
L
G
Q
---------------
V
P
M
A
V
I
-----------
S
G
P
S
L
A
T
E
V
A
A
N
L
P
T
A
V
S
L
A
S
N
N
S
Q
F
S
K
D
L
----
I
E
--
R
---
L
-
H
G-
Q
-
R
F
R
V
Y
K
N
D
D
M
I
G
V
E
L
C
G
S
V
K
N
I
L
A
I
A
T
G
I
S
D
G
------
L
K
L
G
-----
S
N
A
R
A
A
L
I
T
R
G
L
T
E
M
G
R
L
V
S
V
F
G
G
---
K
---
Q
E
T
L
T
G
L
A
G
L
G
D
L
V
L
T
C
T
D
N
Q
S
R
N
R
R
F
G
L
A
L
G
E
-
G
---
V
D
K
K
E
A
Q
Q
A
----
I
--
G
Q
----
A
I
E
G
L
Y
N
T
D
Q
V
H
A
L
A
Q
K
H
A
--
I
--
E
M
P
L
T
F
Q
V
-
H
R
I
L
-
H
E
D
L
D
-
P
Q
Q
A
V
Q
E
L
L
E
R
-----------
22
PsiBlast_CBE
87.54
31%
-95
- C1 -
3K96
2
GPDA_COXBU
B:
[32-336]
---------
I
A
I
L
G
A
G
S
W
G
T
A
L
A
L
V
L
A
-------
R
K
-
G
-------
Q
K
V
R
L
--
W
S
Y
E
S
D
--
H
V
-----
D
E
M
---------
Q
A
EG
V
N
------
N
------
R
---
Y
-
L
P
N
Y
---
P
-
F
P
-----
E
T
L
--------
K
A
Y
C
-
D
L
K
A
S
-
L
EGVTD
I
L
I
V
V
P
S
F
A
F
H
E
V
I
T
--
R
-------
M
-------
K
----
P
---------------------
L
-
I
D
A
K
T
R
I
A
WGTKGL
A
K
G
S
R
L
--
L
--
H
--
E
V
V
--
A
T
E
L
G
Q
---------------
V
P
M
A
V
I
-----------
S
G
P
S
L
A
T
E
V
A
A
N
L
P
T
A
V
S
L
A
S
N
N
S
Q
F
S
K
D
L
----
I
E
--
R
---
L
-
H
G-
Q
-
R
F
R
V
Y
K
N
D
D
M
I
G
V
E
L
C
G
S
V
K
N
I
L
A
I
A
T
G
I
S
D
G
------
L
K
L
G
-----
S
N
A
R
A
A
L
I
T
R
G
L
T
E
M
G
R
L
V
S
V
F
G
G
---
K
---
Q
E
T
L
T
G
L
A
G
L
G
D
L
V
L
T
C
T
D
N
Q
S
R
N
R
R
F
G
L
A
L
G
E
-
G
---
V
D
K
K
E
A
Q
Q
A
----
I
--
G
Q
----
A
I
E
G
L
Y
N
T
D
Q
V
H
A
L
A
Q
K
H
A
--
I
--
E
M
P
L
T
F
Q
V
-
H
R
I
L
-
H
E
D
L
D
-
P
Q
Q
A
V
Q
E
L
L
E
R
-----------
44
Fugue
87.25
31%
-101
- C1 -
1EVY
1
GPDA_LEIME
A:
[9-357]
KD
E
L
L
Y
L
N
K
A
V
V
F
G
S
G
A
F
G
T
A
L
A
M
V
L
S
-------
K
K
-
C
-------
R
-
E
V
C
--
V
W
-
H
M
N
---
E
-----
E
E
V
---------
R
L
--
V
N
------
E
------
K
---
R
-
E
N
V
L
---
F
-
L
K
GVQL
A
S
N
I
--------
T
F
T
S
-
D
V
E
K
A
-
Y
NGAE
I
I
L
F
V
I
P
T
Q
F
L
R
G
F
F
E
--
K
SG
G
N
L
I
A
Y
-------
A
----
K
---------------------
E
-
K
Q
V
P
V
L
V
C
------
T
K
G
I
E
R
--
S
--
T
--
L
K
F
--
P
A
E
I
I
G
E
F
L
P
--------
S
--
P
L
L
S
V
L
-----------
A
G
P
S
F
A
I
E
V
A
T
G
V
F
T
C
V
S
I
A
S
A
D
I
N
V
A
R
R
L
----
Q
R
--
I
M
ST
G
-
D
--
R
-
S
F
V
C
W
A
T
T
D
T
V
G
C
E
V
A
S
A
V
K
N
V
L
A
I
G
S
G
V
A
N
G
------
L
G
M
G
-----
L
N
A
R
A
A
L
I
M
R
G
L
L
E
I
R
D
L
T
A
A
L
G
G
---
D
---
G
S
A
V
F
G
L
A
G
L
G
D
L
Q
L
T
C
S
S
E
L
S
R
N
F
T
V
G
K
K
L
G
K
-
G
---
L
P
I
E
E
I
Q
---------
R
A
----
V
A
E
G
V
A
T
A
D
P
L
M
R
L
A
K
Q
L
K
--
V
--
K
M
P
L
C
H
Q
I
-
Y
E
I
V
Y
K
K
K
N
P
-
R
D
A
L
A
D
L
L
S
C
G
LQDEGLPPLFK
24
HHSearch
85.41
32%
-96
- C1 -
1EVY
1
GPDA_LEIME
A:
[16-343]
-------
N
K
A
V
V
F
G
S
G
A
F
G
T
A
L
A
M
V
L
S
-------
K
K
-
C
-------
R
E
V
C
V
--
W
H
-
M
N
E
--
E
E
-----
V
R
L
---------
V
N
--
E
K
------
R
ENVLFL
K
---
G
-
V
Q
L
A
---
S
-
N
I
----
T
F
T
S
--------
D
V
E
K
A
Y
N
G
A
E
-
I
-----
I
L
F
V
I
P
T
Q
F
L
R
G
F
F
E
K
S
G
-------
G
-------
N
L
I
A
Y
A
K
--------------------
E
-
K
Q
V
P
V
L
V
C
------
T
K
G
I
E
R
--
S
--
T
--
L
K
F
--
P
A
E
I
I
G
E
F
L
P
--------
S
--
P
L
L
S
V
L
-----------
A
G
P
S
F
A
I
E
V
A
T
G
V
F
T
C
V
S
I
A
S
A
D
I
N
V
A
R
R
L
----
Q
R
--
I
---
M
S
T
GD
R
-
S
F
V
C
W
A
T
T
D
T
V
G
C
E
V
A
S
A
V
K
N
V
L
A
I
G
S
G
V
A
N
G
------
L
G
M
G
-----
L
N
A
R
A
A
L
I
M
R
G
L
L
E
I
R
D
L
T
A
A
L
G
G
---
D
---
G
S
A
V
F
G
L
A
G
L
G
D
L
Q
L
T
C
S
S
E
L
S
R
N
F
T
V
G
K
K
L
G
K
-
G
---
L
P
I
E
E
I
Q
R
---------
A
----
V
A
E
G
V
A
T
A
D
P
L
M
R
L
A
K
Q
L
K
--
V
--
K
M
P
L
C
H
Q
I
-
Y
E
I
V
-
Y
K
K
K
N
P
R
D
A
L
A
D
L
L
S
C
G
-----------
26
HHSearch
83.84
29%
-87
- C1 -
3K96
1
GPDA_COXBU
A:
[30-350]
-------
H
P
I
A
I
L
G
A
G
S
W
G
T
A
L
A
L
V
L
A
-------
R
K
-
G
-------
Q
K
V
R
L
--
W
S
-
Y
E
S
--
D
H
-----
V
D
E
---------
M
Q
--
A
E
G-----
V
NNRYL-
P
---
N
-
Y
P
F
P
---
E
-
T
L
----
K
A
Y
C
--------
D
L
K
A
S
L
E
G
V
T
-
D
-----
I
L
I
V
V
P
S
F
A
F
H
E
V
I
T
R
M
K
-------
P
-------
L
----
I
---------------------
D
-
A
K
T
R
I
A
W
G
------
T
K
G
L
A
K
--
G
--
S
--
R
-
L
--
L
H
E
V
V
A
T
E
L
G
--------
Q
--
V
P
M
A
V
I
-----------
S
G
P
S
L
A
T
E
V
A
A
N
L
P
T
A
V
S
L
A
S
N
N
S
Q
F
S
K
D
L
----
I
E
--
R
---
L
H
G
--
Q
-
R
F
R
V
Y
K
N
D
D
M
I
G
V
E
L
C
G
S
V
K
N
I
L
A
I
A
T
G
I
S
D
G
------
L
K
L
G
-----
S
N
A
R
A
A
L
I
T
R
G
L
T
E
M
G
R
L
V
S
V
F
G
G
---
K
---
Q
E
T
L
T
G
L
A
G
L
G
D
L
V
L
T
C
T
D
N
Q
S
R
N
R
R
F
G
L
A
L
G
E
-
G
---
V
D
K
K
E
A
Q
Q
A
----
I
--
G
Q
----
A
I
E
G
L
Y
N
T
D
Q
V
H
A
L
A
Q
K
H
A
--
I
--
E
M
P
L
T
F
Q
V
-
H
R
I
L
-
H
E
D
L
D
P
Q
Q
A
V
Q
E
L
L
E
R
S
-----------
10
PsiBlast_PDB
79.22
27%
-78
- C1 -
2PLA
3
GPD1L_HUMAN
A:
[6-317]
-------
L
K
V
C
I
V
G
S
G
N
W
G
S
A
V
A
K
I
I
G
----------
N
-------
N
-
V
K
K
--
L
Q
-
K
F
A
--
S
T
-----
V
K
M
W
V
F
E
E
T
V
NG
R
K
--
L
T
------
D
------
I
---
I
-
N
N
D
H
------------
E
N
V
--------
K
Y
L
P
-
G
H
K
L
P
-
E
-----
N
V
V
A
M
S
--
N
L
S
E
A
V
Q
--
D
-------
A
-------
D
----
L
L
V
F
V
I
PHQF
I
H
R
I
C
D
E
I
TGRV
P
-
K
K
A
L
G
I
T
L
------
I
K
G
I
D
E
--
G
--
P
--
E
G
L
KL
I
S
D
I
I
R
E
K
M
G
--------
I
--
D
-
I
S
V
L
-----------
M
G
A
N
I
A
N
E
V
A
A
E
K
F
C
E
T
T
I
G
S
K
V
M
E
N
G
L
L
F
----
K
E
L
L
Q
---
T
-
P
--
N
-
F
-
R
I
T
V
V
D
D
A
D
T
V
E
L
C
G
A
L
K
N
I
V
A
V
G
A
G
F
C
D
G
------
L
R
C
G
-----
D
N
T
K
A
A
V
I
R
L
G
L
M
E
M
I
A
F
A
R
I
F
C
K
GQV
S
---
T
A
T
F
L
E
S
C
G
V
A
D
L
I
T
T
C
Y
G
--
G
R
N
R
R
V
A
E
A
F
A
R
-
T
G--
K
T
I
E
E
L
E
K
E
----
M
LN
G
Q
----
K
L
Q
G
P
Q
T
S
A
E
V
Y
R
I
L
K
Q
K
G
--
L
--
L
D
K
F
P
L
F
T
-
A
V
Y
Q
-
I
C
Y
E
S
-
R
P
V
Q
E
M
L
S
C
L
Q
-----------
27
HHSearch
78.39
24%
-92
- C1 -
1TXG
5
GPDA_ARCFU
A:
[1-333]
-------
M
I
V
S
I
L
G
A
G
A
M
G
S
A
L
S
V
P
L
V
-------
D
N
-
G
-------
N
E
V
R
I
--
W
G
-
T
E
F
D
T
E
I
-----
L
K
S
---------
I
S
--
A
G
------
R
E-----
H
PRL
G
-
V
K
L
N
---
G
V
E
I
----
F
W
P
E
--------
Q
L
E
K
C
L
E
N
A
E
-
V
-----
V
L
L
G
V
S
T
D
G
V
L
P
V
M
S
R
I
L
-------
P
-------
Y
----
L
---------------------
K
--
D
Q
Y
I
V
L
I
------
S
K
G
L
I
D
--
F
--
D
NS
V
L
T
--
V
P
E
A
V
W
R
L
K
H
--------
D
LR
E
R
T
V
A
I
-----------
T
G
P
A
I
A
R
E
V
A
K
R
M
P
T
T
V
V
F
S
S
P
S
E
S
S
A
N
K
M
----
K
E
--
I
---
F
E
T
--
E
-
Y
F
G
V
E
V
T
T
D
I
I
G
T
E
I
T
S
A
L
K
N
V
Y
S
I
A
I
A
W
I
R
G
------
Y
E
S
R
K
NVEM
S
N
A
K
G
V
I
A
T
R
A
I
N
E
M
A
E
L
I
E
I
L
G
G
---
D
---
R
E
T
A
F
G
L
S
G
F
G
D
L
I
A
T
F
R
G
--
G
R
N
G
M
L
G
E
L
L
G
K
-
G
---
L
S
I
D
E
A
M
E
E
L
E
R
R
G
--
V
G
----
V
V
E
G
Y
K
T
A
E
K
A
Y
R
L
S
S
K
I
N
--
A
--
D
T
K
L
L
D
S
I
-
Y
R
V
L
-
Y
E
G
L
K
V
E
E
V
L
F
E
L
A
T
F
K
-----------
25
HHSearch
77.14
23%
-85
* C1 *
1X0V
6
GPDA_HUMAN
A:
[9-349]
-------
K
K
V
C
I
V
G
S
G
N
W
G
S
A
I
A
K
I
V
G
G
N
A
A
Q
L
A
Q
F
-
D
-------
P
R
V
T
M
--
W
V
-
F
E
E
--
D
I
GGKK
L
T
E
I
---------
I
N
--
T
Q
HENVKY
L
------
P
---
G
-
H
K
L
P
---
P
-
N
V
----
V
A
V
P
--------
D
V
V
Q
A
A
E
D
A
D
-
I
-----
L
I
F
V
V
P
H
Q
F
I
G
K
I
C
D
Q
L
K
-------
G
-------
H
----
L
---------------------
K
-
A
N
A
T
G
I
S
L
------
I
K
G
V
D
E
--
G
PN
G
--
L
K
L
--
I
S
E
V
I
G
E
R
L
G
-----------
I
P
M
S
V
L
-----------
M
G
A
N
I
A
S
E
V
A
D
E
K
F
C
E
T
T
I
G
C
K
D
P
A
Q
G
Q
L
L
----
K
E
--
L
---
M
Q
T
--
P
-
N
F
R
I
T
V
V
Q
E
V
D
T
V
E
I
C
G
A
L
K
N
V
V
A
V
G
A
G
F
C
D
G
------
L
G
F
G
-----
D
N
T
K
A
A
V
I
R
L
G
L
M
E
M
I
A
F
A
K
L
F
C
S
---
G
PVS
S
A
T
F
L
E
S
C
G
V
A
D
L
I
T
T
C
Y
G
--
G
R
N
R
K
V
A
E
A
F
A
R
T
G
---
K
S
I
E
Q
L
E
K
E
LL--
N
--
G
Q
----
K
L
Q
G
P
E
T
A
R
E
L
Y
S
I
L
Q
H
K
G
--
L
VD
K
F
P
L
F
M
A
V
-
Y
K
V
C
-
Y
E
G
Q
P
V
G
E
F
I
H
C
L
Q
N
H
P
-----------
29
HHSearch
72.09
21%
-87
- C1 -
1YJ8
-
?
A:
[22-366]
-------
L
K
I
S
I
L
G
S
G
N
W
A
S
A
I
S
K
V
V
G
-------
T
N
-
A
K
N
NYLFE
N
E
V
R
M
--
W
I
-
R
D
E
--
F
-ER
M
--
V
D
I
---------
I
N
--
N
K
HENTKY
L
------
K
---
G
-
V
P
L
P
---
H
-
N
I
----
V
A
H
S
--------
D
L
A
S
V
I
N
D
A
D
-
L
-----
L
I
F
I
V
P
C
Q
Y
L
E
S
V
L
A
S
I
K
-------
E
-------------IKI------------------
A
-
S
H
A
K
A
I
S
L
------
T
K
G
F
I
V
K
K
N
--
Q
--
M
K
L
--
C
S
N
Y
I
S
D
F
L
N
-----------
I
P
C
S
A
L
-----------
S
G
A
N
I
A
M
D
V
A
M
E
N
F
S
E
A
T
I
G
G
N
D
K
D
S
L
V
I
W
----
Q
R
--
V
---
F
D
L
--
P
-
Y
F
K
I
N
C
V
N
E
T
I
E
V
E
I
C
G
A
L
K
N
I
I
T
L
A
C
G
F
C
D
G
------
L
N
L
P
-----
T
N
S
K
S
A
I
I
R
N
G
I
N
E
M
I
L
F
G
K
V
F
F
Q
KF-
N
---
E
N
I
L
L
E
S
C
G
F
A
D
I
I
T
S
F
L
A
--
G
R
N
A
K
C
S
A
E
F
I
K
-
S
TPK
K
T
W
E
E
L
E
N
E
IL--
K
--
G
Q
----
K
L
Q
G
T
V
T
L
K
Y
V
Y
H
M
I
K
E
K
N
MT
N
--
E
F
P
L
F
T
V
L
-
H
K
I
S
-
F
E
N
E
D
P
S
S
L
L
K
T
F
M
N
N
K
-----------
14
PsiBlast_PDB
69.85
26%
-70
- C1 -
1TXG
5
GPDA_ARCFU
A:
[1-303]
-------
M
I
V
S
I
L
G
A
G
A
M
G
S
A
L
S
V
P
L
V
-------
D
N
G
N
-------
E
-
V
R
I
--
W
G
-
T
E
F
--
D
T
-----
E
I
L
---------
K
S
--
I
---------------------------
S
-
A
G
----
R
E
H
P
--------
R
L
G
V
-
K
L
N
G
---------
V
E
I
F
W
P
E
Q
L
E
K
C
L
E
--
N
-------
A
-------
E
----
V
VLLGV----------------
S
-
T
D
G
V
L
P
V
M
------
S
R
I
L
P
Y
--
L
--
K
--
D
Q
Y
--
I
V
L
I
S
K
G
L
I
D
F
DNSVLT
V
P
--
E
A
V
W
R
L
KHDLRER
T
V
A
I
T
G
P
A
I
A
R
E
V
A
K
R
M
P
T
T
V
V
F
S
S
P
S
E
S
S
A
N
K
M
----
K
E
--
I
---
F
-
E
--
T
E
Y
F
G
V
E
V
T
T
D
I
I
G
T
E
I
T
S
A
L
K
N
V
Y
S
I
A
I
A
W
I
R
G
Y
E
S
R
K
N
V
E
M
S
-----
N
-
A
K
G
V
I
A
T
R
A
I
N
E
M
A
E
L
I
E
I
L
G
G
---
D
---
R
E
T
A
F
G
L
S
G
F
G
D
L
I
A
T
F
R
G
--
G
R
N
G
M
L
G
E
L
L
G
K
-
G
---
L
S
I
D
E
A
M
E
E
----
L
--
E
R
R
GVG
V
V
E
G
Y
K
T
A
E
K
A
Y
R
L
S
S
K
I
N
--
A
--
D
T
K
L
L
D
S
I
-
Y
R
V
L
-
Y
E
G
L
K
-
V
E
E
V
L
F
E
L
A
T
F
-----------