@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_0912: (2015-12-19 )
MEHKEIVIGVDIGSRKICAIVAEFKDGILRIIGTAHQDSKEINSKAIKRGRINSLAHASNAIKEVINSAKKMAGLNADEDRNNPISSFRESYHPKTKAIVSFSGAYTESIRDVTGVASTKDNVVTIDEINRAINNACAKAGLDNDKHILHALPYRFTLDKQEVNDPLGMSGTRLEVFIHIVYTEKNNIENLEKIMIQSGVEIENIVINSYAASIATLSNDERELGVACVDMGGETCNLTIYSGNSIRYNKYLPVGSHHLTTDLSHMLNTPFPYAEEVKIKYGDLSFESGAETPSQSVQIPTTGSDGHESHIVPLSEIQTIMRERALETFKIIHRSIQDSGFEEHLGGGVVLTGGMALMKGIKELARTHFTNYPVRLATPVEKYNIMGMFEDLKDPRFSVVVGLILYKAGGHTNYERDSKGIIRYHESDDYIRKAHQSNPTPHIHSSPTERNLSDLKTPSAPLNTAKNDDFLPIKPTEQKGFFQNLLDKISKIF
Atome Classification :
(20 SA)
.........10........20..-.-.....30........40......--.-.50.---.......60........70.....-----...-------------80........90.--.......100..--.....---------110....-.---..120----......-----...130.......-140.......150.......-160.-.......170-.-...-...---------180...----....190.....--..200.......210...-...--.---220--.........230.......240.--.....---.-----.250-------....---------.....260.------......270-----------------.-------------------........280-------------........290.....-----------..-----.300-------.--.----...----------...--310.-.---.....320.-----..---.....-------.330.......---340-.......350.......360--.....----...370-......----.380.--......----..390.......400--------.......410.......420..-----.....430.......440.......450-.......460.......470.----......480.......490.---------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MEH
K
E
I
V
I
G
V
DIGS
R
K
I
C
A
I
V
A
E
-F-K
D
G
I
L
R
I
IGTAHQ
D
S
K
E
I
N
S
K
A
I
--K-RGR
I
---
N
S
L
A
H
A
S
N
A
I
K
E
V
I
N
S
A
K
K
MAGLN-----ADE-------------DRNN
P
I
S
S
F
R
E
SY--HPK
T
K
A
I
V
S
FSG--
A
Y
T
E
S
---------
I
R
D
VTGV-A---STK------D
N
V
V
T
I
-----
D
E
I
N
R
A
I
N
N
A
C
A
K-AGLDND
K
H
I
L
H
ALP
Y
R
F
TL
D
-
K
Q
-E-VNDPLGMSG
T
-
R
-
L
E
V
-
F
I
H
---------
I
V
Y
TEK----N
N
I
E
N
L
E
K
I
M
I
Q--SGV
E
I
E
N
I
V
INSY
A
A
S
I
A-TLS--N---D----EREL
G
V
A
C
V
DMGG
E
T
C
N
L
T
I
Y-S--G
N
S
I
R
---
Y
-----NK---------YLPV---------GSHH
L
T
T
D
L
------
S
H
M
LNTP-------------------F-------------------PYA
E
E
V
K
I
K
Y--------------GD
L
S
FESGAE-TPSQ
S
-----------
V
Q-----IPT--------T--G----SDG----------HES--
H
I
V
P
-
L
---
S
E
I
Q
T
I
--
M
-----
R
E
---
R
A
L
E
T
-------
F
K
I
I
H
R
S
I
QDS---G
F
E
-
E
HLGG
G
V
V
LT
G
G
M
A
L
M
K
G
I
---
K
E
L
A
R
----
T
HFTNY-
P
V
R
LAT----P
V
--
E
--
K
Y
N
I
M
G
----
M
F
E
DLKDP
R
F
S
V
V
V
G
--------
L
I
L
YKAGGHTNYERDSK
G
I
I
R
Y
-----HES
D
D
Y
I
R
K
A
HQSNPTPHIHSSPTERN
L
-
S
DLKTPSAPLNTAKNDDFLPI----KPTEQK
G
F
F
Q
N
L
L
D
K
I
S
KIF---------------------------------------------
21
HHSearch
94.41
23%
-96
- C4 -
3WT0
1
FTSA_STAAW
A:
[20-394]
--
E
E
H
Y
Y
V
S
I
D
I
G
S
S
S
V
K
T
I
V
G
E
-
K
-
F
H
N
G
I
N
V
I
G
T
G
Q
T
Y
-----
T
S
G
I
--
K
-
N
G
L
I
---
D
D
F
D
I
A
R
Q
A
I
K
D
T
I
K
K
A
S
I
A
S
G
V
D
-----
I
---------------------------------
K
E
V
F
L
K
L
P
I
IG
T
E
V
Y
D
---------
E
S
----
N
-----
E
I
D
F
Y
E
---
D
T
E
I
N
G
-----
S
H
I
E
K
V
L
E
G
I
R
E
K
--
N
D
V
Q
E
T
E
V
I
N
V
F
P
I
R
F
I
V
D
-
K
E
-
N
E
V
S
D
P
K
E
L
I
A
R
H
S
-
L
K
V
-
E
A
G
---------
V
I
A
I
Q
K
----
S
I
L
I
N
M
I
K
C
V
E
A
--
C
G
V
D
V
L
D
V
Y
S
D
A
Y
N
Y
G
S
I
-
L
T
A
------
T
----
E
K
E
L
G
A
C
V
I
D
I
G
E
D
V
T
Q
V
A
F
Y
-
E
--
R
G
E
L
V
---
D
-----
A
D
---------
S
I
E
M
---------
A
G
R
D
I
T
D
D
I
------
A
Q
G
L
N
T
S
-------------------
Y
-------------------
E
T
A
E
K
V
K
H
Q
Y
--------------
G
H
A
F
Y
D
S
A
---
S
D
Q
D
I
-----------
F
T
-----
V
E
Q
--------
V
--------
D
S
----------
D
E
T
--
V
Q
Y
T
-
Q
---
K
D
L
S
D
F
--
I
-----
E
A
---
R
V
E
E
I
-------
F
F
E
V
F
D
V
L
Q
D
L
---
G
L
T
--
K
V
N
G
G
F
I
V
T
G
G
S
A
N
L
L
G
V
---
K
E
L
L
S
----
D
M
V
-
S
E
-
K
V
R
I
H
T
----
P
S
--
Q
--
M
------------
G
I
R
K
P
E
F
S
S
A
I
S
--------
T
I
S
S
S
I
A
F
D
E
L
L
D
-------------------------------------------------------------------------------------------------------------------------------------
22
HHSearch
93.31
23%
-102
- C4 -
3WQT
4
FTSA_STAAR
A:
[20-390]
----
H
Y
Y
V
S
I
D
I
G
S
S
S
V
K
T
I
V
G
E
-
K
F
H
-
N
G
I
N
V
I
G
T
G
Q
T
Y
-----
T
S
G
I
--
K
-
N
G
L
I
---
D
D
F
D
I
A
R
Q
A
I
K
D
T
I
K
K
A
S
I
A
S
G
V
D
-----
I
---------------------------------
K
E
V
F
L
K
L
P
I
IG
T
E
V
Y
D
---------
E
S
----
N
-----
E
I
D
F
YE---
D
T
E
I
N
G
-----
S
H
I
E
K
V
L
E
G
I
R
E
------
Q
E
T
E
V
I
N
V
F
P
I
R
F
I
V
D
-
K
E
-
N
E
V
S
D
P
K
E
L
I
A
R
H
S
-
L
K
V
-
E
A
G
---------
V
I
A
I
Q
K
----
S
I
L
I
N
M
I
K
C
V
E
A
--
C
G
V
D
V
L
D
V
Y
S
D
A
Y
N
Y
G
S
I
-
L
T
---
A
---
T
----
E
K
E
L
G
A
C
V
I
D
I
G
E
D
V
T
Q
V
A
F
Y
-
E
--
R
G
E
L
V
---
D
-----
A
D
---------
S
I
E
M
---------
A
G
R
D
I
T
D
D
I
------
A
Q
G
L
N
T
S
-------------------
Y
-------------------
E
T
A
E
K
V
K
H
Q
Y
--------------
G
H
A
F
Y
D
S
A
---
S
D
Q
D
I
-----------
F
T
-----
V
E
Q
--------
V
--
D
------
S
----------
D
E
T
--
V
Q
Y
T
-
Q
---
K
D
L
S
D
F
--
I
-----
E
A
---
R
V
E
E
I
-------
F
F
E
V
F
D
V
L
Q
D
L
---
G
L
T
--
K
V
N
G
G
F
I
V
T
G
G
S
A
N
L
L
G
V
---
K
E
L
L
S
----
D
M
V
-
S
E
-
K
V
R
I
H
T
----
P
S
--
Q
--
M
G
------------
I
R
K
P
E
F
S
S
A
I
S
--------
T
I
S
S
S
I
A
F
D
E
L
L
D
-------------------------------------------------------------------------------------------------------------------------------------
42
Fugue
88.61
21%
-81
- C4 -
1E4F
-
?
T:
[7-390]
---
T
V
F
Y
T
S
I
D
I
G
S
R
Y
I
K
G
L
V
L
G
-
K
-
R
D
Q
E
W
E
A
L
A
F
S
S
V
K
S
R
G
-----
L
--
D
-
E
G
E
I
---
K
D
A
I
A
F
K
E
S
V
N
T
L
L
K
E
L
E
E
Q
L
Q
K
S
-----
L
--------------------------------
R
S
D
F
V
I
S
F
S
S
--
V
S
F
E
R
---------
E
D
T
V
I
E
R
-
D
---
F
G
E
------
E
K
R
S
I
T
-----
L
D
I
L
S
E
M
Q
S
E
A
L
E
-
K
L
K
E
N
G
K
T
P
L
H
I
F
S
K
R
Y
L
L
D
D
E
R
-
I
-
V
F
N
P
L
D
M
K
A
S
-
K
-
I
A
I
-
E
Y
T
---------
S
I
V
V
P
L
----
K
V
Y
E
M
F
Y
N
F
L
Q
D
--
T
V
K
S
P
F
Q
L
K
S
S
L
V
S
T
A
E
G
-
V
L
T
--
T
---
P
----
E
K
D
R
G
V
V
V
V
N
L
G
Y
N
F
T
G
L
I
A
Y
-
K
--
N
G
V
P
I
---
K
-----
I
S
---------
Y
V
P
V
---------
G
M
K
H
V
I
K
D
V
------
S
A
V
L
D
T
S
-------------------
F
-------------------
E
E
S
E
R
L
I
I
T
H
--------------
G
N
A
V
-----
Y
-
N
D
L
K
E
-----------
E
E
-----
I
Q
Y
--------
R
--
G
----
L
D
G
----------
N
T
I
--
K
T
T
T
-
A
---
K
K
L
S
V
I
--
I
-----
H
A
---
R
L
R
E
I
-------
M
S
K
S
K
K
F
F
R
E
V
---
E
A
K
-
I
G
I
P
G
G
V
V
L
T
G
G
G
A
K
I
P
R
I
---
N
E
L
A
T
----
E
V
F
-
K
S
-
P
V
R
T
G
C
----
Y
A
--
N
SD
R
P
S
I
I
N
----
A
D
E
V
A
N
D
P
S
F
A
A
A
F
G
--------
N
V
F
A
----------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
86.88
25%
-61
- C4 -
4A2B
2
?
A:
[13-386]
---------
I
D
I
G
S
R
Y
I
K
G
L
V
------------
L
G
K
R
D
Q
E
W
E
A
L
A
F
S
S
V
--
K
S
R
G
L
D
---
E
G
E
I
K
D
A
I
A
F
K
E
S
V
N
T
L
L
K
------------
E
-------------
L
E
E
Q
L
Q
K
S
L
R
S
D
F
--------
V
I
S
F
S
S
--
V
S
F
E
-----------
R
E
D
T
V
I
-
E
R
D
F
G
E
E
------
K
R
S
I
T
L
-----
D
I
L
S
E
M
Q
S
E
A
L
E
K
-
L
K
-
E
N
G
K
T
P
L
H
I
F
S
K
R
Y
L
L
D
-
D
E
-
R
I
V
F
N
P
L
D
M
K
A
S
-
K
-
I
A
I
E
Y
T
S
---------
I
V
V
P
L
K
V
Y
--
E
M
F
Y
N
F
L
Q
D
T
V
K
--
S
P
F
Q
L
K
S
S
L
V
S
T
---
A
E
G
-
V
L
T
--
T
---
P
----
E
K
D
R
G
V
V
V
V
N
L
G
Y
N
F
T
G
L
I
A
Y
K
N
--
G
V
P
I
K
---
I
-----
S
----------
Y
V
P
V
---------
G
M
K
H
V
I
K
D
V
------
S
A
V
L
D
T
S
-------------------
F
-------------------
E
E
S
E
R
L
I
I
T
H
--------------
G
N
A
V
Y
N
D
L
K
E
-
E
----------------
E
-----
I
Q
Y
--------
R
--
G
----
L
D
G
----------
N
T
I
--
K
T
T
T
-
A
---
K
K
L
S
V
I
--
I
-----
H
A
---
R
L
R
E
I
M
S
K
S
K
K
F
F
R
E
V
E
A
K
I
V
E
E
---
G
-
E
-
I
G
I
P
G
G
V
V
L
T
G
G
G
A
K
I
P
R
I
---
N
E
L
A
T
----
E
V
F
K
S
--
P
V
R
T
G
C
----
Y
A
NS
D
--
R
P
S
I
I
N
----
A
D
E
V
A
N
D
P
S
F
A
A
A
F
G
--------
N
V
F
A
V
S
--------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
86.65
25%
-63
- C4 -
1E4F
-
?
T:
[13-386]
---------
I
D
I
G
S
R
Y
I
K
G
L
V
------------
L
G
K
R
D
Q
E
W
E
A
L
A
F
S
S
V
--
K
S
R
G
L
D
---
E
G
E
I
K
D
A
I
A
F
K
E
S
V
N
T
L
L
K
------------
E
-------------
L
E
E
Q
L
Q
K
S
L
R
S
D
F
--------
V
I
S
F
S
S
--
V
S
F
E
-----------
R
E
D
T
V
I
-
E
RDF
G
E
E
------
K
R
S
I
T
L
-----
D
I
L
S
E
M
Q
S
E
A
L
E
K
-
L
K
-
E
N
G
K
T
P
L
H
I
F
S
K
R
Y
L
L
D
-
D
E
-
R
I
V
F
N
P
L
D
M
K
A
S
-
K
-
I
A
I
E
Y
T
S
---------
I
V
V
P
L
K
VY--
E
M
F
Y
N
F
L
Q
D
T
V
K
--
S
P
F
Q
L
K
S
S
L
V
S
T
---
A
E
G
-
V
L
T
--
T
---
P
----
E
K
D
R
G
V
V
V
V
N
L
G
Y
N
F
T
G
L
I
A
Y
K
N
--
G
V
P
I
K
---
I
-----
S
----------
Y
V
P
V
---------
G
M
K
H
V
I
K
D
V
------
S
A
V
L
D
T
S
-------------------
F
-------------------
E
E
S
E
R
L
I
I
T
H
--------------
G
N
A
V
Y
N
D
L
K
E
-
E
----------------
E
-----
I
Q
Y
--------
R
--
G
----
L
D
G
----------
N
T
I
--
K
T
T
T
-
A
---
K
K
L
S
V
I
--
I
-----
H
A
---
R
L
R
E
I
MSKSKKF
F
R
E
V
E
A
K
-----------
I
G
I
P
G
G
V
V
L
T
G
G
G
A
K
I
P
R
I
---
N
E
L
A
T
----
E
V
F
K
S
--
P
V
R
T
G
C
----
Y
A
NS
D
--
R
P
S
I
I
N
----
A
D
E
V
A
N
D
P
S
F
A
A
A
F
G
--------
N
V
F
A
----------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
85.94
24%
-83
- C4 -
3WQU
1
FTSA_STAAR
A:
[23-365]
-------
V
S
I
D
I
G
S
S
S
V
K
T
I
V
G
E
K
F
-
H
N
G
I
-
N
V
I
G
T
G
-----
Q
T
Y
T
S
G
I
--
K
-
N
G
L
I
---
D
D
F
D
I
A
R
Q
A
I
K
D
T
I
K
K
A
S
I
A
S
G
V
D
-----
I
K
E
V
F
L
K
L
P
IIG
T
E
V
Y
D
E
S
N
E
I
D
-----
F
--
Y
E
D
T
E
I
N
G
S
H
I
E
--
K
V
L
E
G
---------
I
R
E
-----
Q
---
E
T
E
---------------------------------------
V
I
N
V
F
P
I
R
F
I
V
D
-
K
E
N
E
-
V
S
D
P
K
E
L
I
A
R
-
H
S
L
K
V
-
E
A
G
---------
V
I
A
I
Q
K
----
S
I
L
I
N
M
I
K
C
V
E
A
--
C
G
V
D
V
L
D
V
Y
S
D
A
Y
N
Y
G
-
S
-
I
L
T
--
A
---
T
----
E
K
E
L
G
A
C
V
I
D
I
G
E
D
V
T
Q
V
A
F
Y
-
E
--
R
G
E
L
V
---
D
-----
A
D
---------
S
I
E
M
---------
A
G
R
D
I
T
D
D
I
------
A
Q
G
L
N
T
S
-------------------
Y
-------------------
E
T
A
E
K
V
K
H
Q
Y
--------------
G
H
A
F
Y
D
S
A
S
D
-
Q
D
I
F
T
-----------
V
E
-------------------
Q
----
V
D
S
----------
D
E
T
--
V
Q
Y
T
-
Q
---
K
D
L
S
D
F
--
I
-----
E
A
---
R
V
E
E
I
-------
F
F
E
V
F
D
V
L
Q
D
L
---
G
L
T
-
K
-
V
N
G
G
F
I
V
T
G
G
S
A
N
L
L
G
V
---
K
E
L
L
-----
S
D
M
V
S
E
-
K
V
R
I
H
T
----
P
S
--
Q
--
M
G
I
R
K
P
----
E
F
S
S
A
I
S
T
I
S
S
S
I
A
F
--------
D
E
L
L
D
---------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
85.47
24%
-81
- C4 -
3WQT
3
FTSA_STAAR
A:
[23-365]
-------
V
S
I
D
I
G
S
S
S
V
K
T
I
V
G
E
K
F
-
H
N
G
I
-
N
V
I
G
T
G
-----
Q
T
Y
T
S
G
I
--
K
-
N
G
L
I
---
D
D
F
D
I
A
R
Q
A
I
K
D
T
I
K
K
A
S
I
A
S
G
V
D
-----
I
K
E
V
F
L
K
L
P
IIG
T
E
V
Y
D
E
S
N
E
I
D
-----
F
--
Y
E
D
T
E
I
N
G
S
H
I
E
--
K
V
L
E
G
---------
I
R
E
-----
Q
---
E
T
E
---------------------------------------
V
I
N
V
F
P
I
R
F
I
V
D
-
K
E
N
E
-
V
S
D
P
K
E
L
I
A
R
-
H
S
L
K
V
-
E
A
G
---------
V
I
A
I
Q
K
----
S
I
L
I
N
M
I
K
C
V
E
A
--
C
G
V
D
V
L
D
V
Y
S
D
A
Y
N
Y
G
-
S
-
I
L
T
--
A
---
T
----
E
K
E
L
G
A
C
V
I
D
I
G
E
D
V
T
Q
V
A
F
Y
-
E
--
R
G
E
L
V
---
D
-----
A
D
---------
S
I
E
M
---------
A
G
R
D
I
T
D
D
I
------
A
Q
G
L
N
T
S
-------------------
Y
-------------------
E
T
A
E
K
V
K
H
Q
Y
--------------
G
H
A
F
Y
D
S
A
S
D
-
Q
D
I
F
T
-----------
V
E
-------------------
Q
----
V
D
S
----------
D
E
T
--
V
Q
Y
T
-
Q
---
K
D
L
S
D
F
--
I
-----
E
A
---
R
V
E
E
I
-------
F
F
E
V
F
D
V
L
Q
D
L
---
G
L
T
-
K
-
V
N
G
G
F
I
V
T
G
G
S
A
N
L
L
G
V
---
K
E
L
L
-----
S
D
M
V
S
E
-
K
V
R
I
H
T
----
P
S
--
Q
--
M
G
I
R
K
P
----
E
F
S
S
A
I
S
T
I
S
S
S
I
A
F
--------
D
E
L
L
D
---------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
84.96
25%
-63
- C4 -
4A2A
2
?
A:
[13-386]
---------
I
D
I
G
S
R
Y
I
K
G
L
V
------------
L
G
K
----
W
E
A
L
A
F
S
S
V
--
K
S
R
G
L
D
---
E
G
E
I
K
D
A
I
A
F
K
E
S
V
N
T
L
L
K
------------
E
-------------
L
E
E
Q
L
Q
K
S
L
R
S
D
F
--------
V
I
S
F
S
S
--
V
S
F
E
-----------
R
E
D
T
V
I
-
E
R
D
F
G
E
E
------
K
R
S
I
T
L
-----
D
I
L
S
E
M
Q
S
E
A
L
E
K
-
L
K
-
E
N
G
K
T
P
L
H
I
F
S
K
R
Y
L
L
D
-
D
E
-
R
I
V
F
N
P
L
D
M
K
A
S
-
K
-
I
A
I
E
Y
T
S
---------
I
V
V
P
L
K
V
Y
--
E
M
F
Y
N
F
L
Q
D
T
V
K
--
S
P
F
Q
L
K
S
S
L
V
S
T
---
A
E
G
-
V
L
T
--
T
---
P
----
E
K
D
R
G
V
V
V
V
N
L
G
Y
N
F
T
G
L
I
A
Y
K
N
--
G
V
P
I
K
---
I
-----
S
----------
Y
V
P
V
---------
G
M
K
H
V
I
K
D
V
------
S
A
V
L
D
T
S
-------------------
F
-------------------
E
E
S
E
R
L
I
I
T
H
--------------
G
N
A
V
Y
N
D
L
K
E
-
E
----------------
E
-----
I
Q
Y
--------
R
--
G
----
L
D
G
----------
N
T
I
--
K
T
T
T
-
A
---
K
K
L
S
V
I
--
I
-----
H
A
---
R
L
R
E
I
M
S
K
S
K
K
F
F
R
E
V
E
A
K
-------------
I
P
G
G
V
V
L
T
G
G
G
A
K
I
P
R
I
---
N
E
L
A
T
----
E
V
F
K
S
--
P
V
R
T
G
C
----
Y
A
NS
D
--
R
P
S
I
I
N
----
A
D
E
V
A
N
D
P
S
F
A
A
A
F
G
--------
N
V
F
A
----------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
84.36
23%
-85
- C4 -
3WT0
1
FTSA_STAAW
A:
[25-367]
-------
V
S
I
D
I
G
S
S
S
V
K
T
I
V
G
E
K
F
-
H
N
G
I
-
N
V
I
G
T
G
-----
Q
T
Y
T
S
G
I
--
K
-
N
G
L
I
---
D
D
F
D
I
A
R
Q
A
I
K
D
T
I
K
K
A
S
I
A
S
G
V
D
-----
I
K
E
V
F
L
K
L
P
IIG
T
E
V
Y
D
E
S
N
E
I
D
F
Y
E
D
T
-----------
E
I
N
G
--
S
H
I
E
K
---------
V
--
L
E
G
I
-
R
---
E
K
N
------
D
V
---------------------------
Q
E
T
E
V
I
N
V
F
P
I
R
F
I
V
D
-
K
E
N
E
-
V
S
D
P
K
E
L
I
A
R
-
H
S
L
K
V
-
E
A
G
---------
V
I
A
I
Q
K
----
S
I
L
I
N
M
I
K
C
V
E
A
--
C
G
V
D
V
L
D
V
Y
S
D
A
Y
N
Y
G
-
S
-
I
L
T
--
A
---
T
----
E
K
E
L
G
A
C
V
I
D
I
G
E
D
V
T
Q
V
A
F
Y
-
E
--
R
G
E
L
V
---
D
-----
A
D
---------
S
I
E
M
---------
A
G
R
D
I
T
D
D
I
------
A
Q
G
L
N
T
S
-------------------
Y
-------------------
E
T
A
E
K
V
K
H
Q
Y
--------------
G
H
A
F
Y
D
S
A
S
D
-
Q
D
I
F
T
-----------
V
E
-------------------
Q
----
V
D
S
----------
D
E
T
--
V
Q
Y
T
-
Q
---
K
D
L
S
D
F
--
I
-----
E
A
---
R
V
E
E
I
-------
F
F
E
V
F
D
V
L
Q
D
L
---
G
L
T
-
K
-
V
N
G
G
F
I
V
T
G
G
S
A
N
L
L
G
V
---
K
E
L
L
-----
S
D
M
V
S
E
-
K
V
R
I
H
T
----
P
S
--
Q
--
M
G
I
R
K
P
----
E
F
S
S
A
I
S
T
I
S
S
S
I
A
F
--------
D
E
L
L
D
---------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
84.19
25%
-62
- C4 -
1E4G
2
?
T:
[13-386]
---------
I
D
I
G
S
R
Y
I
K
G
L
V
------------
L
G
K
R
D
Q
E
W
E
A
L
A
F
S
S
V
--
K
S
R
G
L
D
---
E
G
E
I
K
D
A
I
A
F
K
E
S
V
N
T
L
L
K
------------
E
-------------
L
E
E
Q
L
Q
K
S
L
R
S
D
F
--------
V
I
S
F
S
S
--
V
S
F
E
-----------
R
E
D
T
V
I
-
E
RDF
G
E
E
------
K
R
S
I
T
L
-----
D
I
L
S
E
M
Q
S
E
A
L
E
K
-
L
K
-
E
N
G
K
T
P
L
H
I
F
S
K
R
Y
L
L
D
-
D
E
-
R
I
V
F
N
P
L
D
M
K
A
S
-
K
-
I
A
I
E
Y
T
S
---------
I
V
V
P
L
K
VY--
E
M
F
Y
N
F
L
Q
D
T
V
K
--
S
P
F
Q
L
K
S
S
L
V
S
T
---
A
E
G
-
V
L
T
--
T
---
P
----
E
K
D
R
G
V
V
V
V
N
L
G
Y
N
F
T
G
L
I
A
Y
K
N
--
G
V
P
I
K
---
I
-----
S
----------
Y
V
P
V
---------
G
M
K
H
V
I
K
D
V
------
S
A
V
L
D
T
S
-------------------
F
-------------------
E
E
S
E
R
L
I
I
T
H
--------------
G
N
A
V
Y
N
D
L
K
E
-
E
----------------
E
-----
I
Q
Y
--------
R
--
G
----
L
D
G
----------
N
T
I
--
K
T
T
T
-
A
---
K
K
L
S
V
I
--
I
-----
H
A
---
R
L
R
E
I
MSKSKKF
F
R
E
V
E
A
K
------------
G
I
P
G
G
V
V
L
T
G
G
G
A
K
I
P
R
I
---
N
E
L
A
T
----
E
V
F
K
S
--
P
V
R
T
G
C
----
Y
A
NS
D
--
R
P
S
I
I
N
----
A
D
E
V
A
N
D
P
S
F
A
A
A
F
G
--------
N
V
F
A
V
S
--------------------------------------------------------------------------------------------------------------------------------------------
23
HHSearch
76.06
16%
-93
- C4 -
2YCH
3
?
A:
[11-375]
--
P
R
V
E
A
L
G
L
E
I
G
A
S
A
L
K
L
V
E
V
S
-
G
-
N
--
P
P
A
L
K
A
L
A
S
R
P
---
T
P
P
G
L
L
--
M
-
E
G
M
V
---
A
E
P
A
A
L
A
Q
E
I
K
E
L
L
L
E
----
A
R
T
R
-----
K
---------------------------------
R
Y
V
V
T
A
L
S
N
--
L
A
V
I
L
---------
R
P
----
I
-----
Q
V
P
--------
K
M
P
L
-----
K
E
M
E
E
A
V
R
W
E
A
E
R
Y
I
P
F
P
I
-
E
V
V
L
D
F
A
P
L
T
P
L
S
E
-
V
Q
------------
E
-
G
-
E
Q
V
-
Q
V
M
---------
V
A
A
A
R
Q
----
E
A
V
A
G
V
L
E
A
L
R
G
--
A
G
L
V
P
V
V
L
D
V
K
P
F
A
G
L
Y
P
-
L
E
A
R
L
A
---
E
----
E
P
D
R
V
F
L
V
L
D
I
G
A
E
S
T
S
L
V
L
L
-
R
--
G
D
K
P
L
---
A
-----
V
R
---------
V
L
T
L
---------
S
G
K
D
F
T
E
A
I
------
A
R
S
F
N
L
D
-------------------
L
-------------------
L
A
A
E
E
V
K
R
T
Y
----------------------------------------------------------------------------------------------
G
R
I
Y
D
A
--
I
-----
R
P
---
V
L
V
E
L
-------
T
Q
E
L
R
R
S
L
E
F
F
---
R
I
Q
L--
S
P
E
V
G
Y
L
L
G
G
G
S
K
L
R
G
L
---
A
S
L
L
T
----
D
T
L
-
G
V
-
N
L
E
P
V
N
----
P
W
--
E
A-
V
A
V
D
P
K
RFE
S
E
Q
L
Q
E
I
G
P
E
F
A
V
A
L
G
--------
L
A
L
R
G
V
E
P
------------------------------------------------------------------------------------------------------------------------------------------
51
Fugue
62.31
17%
-10
- C1 -
4TWA
11
SYP_PLAF7
A:
[3-497]
---------
M
A
I
T
S
K
K
I
E
N
F
S
D
W
-
Y
-
T
Q
V
I
V
K
-------------
S
E
L
I
--
E
-
Y
Y
D
I
---
S
G
C
Y
I
L
R
P
A
A
Y
Y
I
W
E
C
V
Q
A
F
--
F
N
-----
K
E
I
-------------
K
K
L
N
V
E
N
S
Y
F
P
L
F
VT
K
N
K
L
E
K
E
K
N
H
I
E
--
G
F
S
P
E
---------
V
A
W
V
T
K
Y
G
D
---
S
N
L
------
P
E
E
I
A
I
-----
R
P
T
S
E
T
I
M
Y
S
V
F
P
-
K
W
I
R
S
Y
R
D
L
P
L
K
L
N
Q
W
N
T
V
V
-
R
W
-
E
-
F
K
Q
P
T
P
F
I
R
T
-
R
--
E
F
-
L
W
Q
---------
E
G
H
T
A
H
----
K
N
E
E
E
A
V
K
L
V
F
D
--
I
L
D
L
Y
R
R
W
Y
E
E
Y
L
A
V
P
I
I
-
K
G
I
--
K
---
S
----
E
G
E
------
K
F
G
G
A
N
F
T
S
T
A
E
-
A
--
F
I
S
E
N
---
G
-----
R
A
---------
I
Q
A
A
---------
T
S
H
Y
L
G
T
N
F
------
A
K
M
F
K
I
E
-------------------
F
-------------------
E
D
E
N
E
V
K
Q
Y
V
--------------
H
Q
T
S
W
--
G
C
T
-
T
R
S
I
G
-----------
I
M
-----
I
M
T
--------
H
--
G
----
D
D
K
GLVLPPNVSK
Y
K
V
--
V
I
V
P
-
I
F
Y
K
T
T
D
E
N
A
--
I
-----
H
S
---
Y
C
K
D
I
-------
E
K
I
L
K
N
A
Q
I
N
C
---
V
Y
D
-
D
R
A
S
Y
S
P
G
Y
K
F
N
H
W
E
L
R
G
I
P
I
R
I
E
V
G
P
----
K
D
L
Q
N
N
-
S
C
V
I
V
R
RDNN
E
K
--
C
--
N
V
K
K
E
S
----
V
L
L
E
T
Q
Q
M
L
V
D
I
H
K
N
--------
L
F
L
K
A
K
K
K
L
D
D
S
I
V
Q
---
V
T
S
F
-----
S
E
V
M
N
A
L
N
K
-
K
K
M
V
L
A
P
W
C
E
D
I
A
T
E
E
E
I
K
K
E
T
Q
R
L
S
L
T
L
S
G
A
M
K
P
L
C
I
P
L
DQPP
M
P
P
N
M
K
C
F
W
S
G
K
P
A
K
R
W
C
L
F
G
R
SY-----------------------------------------
30
HHSearch
59.13
18%
-74
- C4 -
3QFU
3
GRP78_YEAST
A:
[167-392]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
Q
R
Q
A
T
K
D
A
G
T
I
--
A
G
L
N
V
L
R
I
V
N
E
P
T
A
A
A
I
A
-
Y
G
L
--
D
---
K
S---
D
K
E
H
Q
I
I
V
Y
D
L
G
G
G
T
F
D
V
S
L
L
-
S
--
I
E
N
G
V
---
F
EVQ
A
T
S
G
---------
D
T
H
L
---------
G
G
E
D
F
D
Y
K
I
------
V
R
Q
L
I
K
A
-------------------
F
K
K
K
HGIDVSDN
N
K
A
L
A
K
L
K
R
E
A
E
K
A
K
R
A
L
--------------
S
S
Q
M
S
---------
T
R
-----------
I
E
-----
I
D
S
--------
F
--
V
----
D
G
I
----------
D
L
S
--
E
T
L
T
-
R
---
A
K
F
E
E
L
--
N
-----
L
D
---
L
F
K
K
T
-------
L
K
P
V
E
K
V
L
Q
D
S
---
G
L
E
-
K
K
D
V
D
D
I
V
L
V
G
G
S
T
R
I
P
K
V
---
Q
Q
L
L
E
----
S
Y
F
D
G
K
-
K
A
S
K
---------------------------
G
I
N
P
D
E
A
V
A
Y
G
--------
A
A
V
Q
A
G
V
L
S
-----------------------------------------------------------------------------------------------------------------------------------------
31
HHSearch
58.90
15%
-74
- C4 -
3I33
3
HSP72_HUMAN
A:
[160-400]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
A
---------
V
I
T
V
P
A
YFN
D
S
Q
R
Q
A
T
K
D
A
G
T
I
--
T
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
-
Y
G
L
--
D
---
K
KGCA
G
G
E
K
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
-
T
I
E
D
G
I
F
E
---
V
K
S
T
--
A
G
---------
D
T
H
L
---------
G
G
E
D
F
D
N
R
M
------
V
S
H
L
A
E
E
F
K
R
K
HKKDIGPN
K
R
A
V
R
R
L
R
-------------------
T
A
C
E
R
A
K
R
T
L
--------------
S
S
S
T
Q
---------
A
S
-----------
I
E
-----
I
D
S
--------
L
--
Y
----
E
G
V
----------
D
F
Y
--
T
S
I
T
-
R
---
A
R
F
E
E
L
--
N
-----
A
D
---
L
F
R
G
T
-------
L
E
P
V
E
K
A
L
R
D
A
---
K
L
D
-
K
G
Q
I
Q
E
I
V
L
V
G
G
S
T
R
I
P
K
I
---
Q
K
L
L
Q
----
D
F
F
N
G
K
-
E
L
N
K
---------------------------
S
I
N
P
D
E
A
V
A
Y
G
--------
A
A
V
Q
A
A
I
L
I
-----------------------------------------------------------------------------------------------------------------------------------------
46
Fugue
55.53
14%
-33
- C4 -
2QXL
3
HSP7F_YEAST
A:
[2-656]
-----
T
P
F
G
L
D
L
G
N
N
--
N
S
V
L
A
V
-
A
-
R
N
R
G
I
D
I
V
V
N
-
E
V
S
N
R
S
T
P
S
V
V
G
F
G
P
-
K
N
R
Y
L
G
E
T
G
K
N
K
Q
T
S
N
I
K
N
T
V
A
N
L
K
R
I
I
G
L
D
YHHPD
F
E
Q
-------------
E
S
K
H
F
T
S
K
L
V
E
L
D
--
D
K
K
T
G
A
E
V
R
F
A
G
--
E
K
H
V
F
S
A
T
Q
L
A
A
M
F
I
D
K
V
K
D
T
-
V
---
K
Q
D
TK
A
N
I
T
D
V
C
I
A
V
P
PWYT
E
E
Q
R
Y
N
I
A
D
A
A
R
I
-
A
G
L
N
P
V
R
I
V
N
D
V
T
A
A
G
V
S
Y
G
-
I
F
-
K
-
T
D
L
P
E
G
E
E
K
P
-
R
-
I
V
A
-
F
V
D
I
G
HS
S
Y
T
C
S
I
M
A
F
K
K
----
G
Q
L
K
V
L
G
T
A
C
D
K
HF
G
G
R
D
F
D
L
A
I
T
E
H
F
A
D
E
F
K
-
T
K
Y
--
K
IDI
R
----
E
N
P
K
A
Y
N
R
I
L
T
A
A
E
K
L
K
K
V
L
S
-
A
--
N
T
N
A
P
---
F
-----
S
V
E
SVMND
V
D
V
S
S
Q
L
---------
S
R
E
E
L
E
E
L
V
------
K
P
L
L
E
R
V
-------------------
T
-------------------
E
P
V
T
K
A
L
A
Q
A
KLSAEEVD
F
V
E
I
I
G
G
T
T
R
I
P
T
L
K
Q
-
S
I
S
E
A
-----------
F
G
-----
K
P
L
--------
S
--
T
----
T
L
N
----------
Q
D
E
--
A
I
A
K
-
G
---
A
A
F
I
C
A
--
I
-----
H
S
---
R
P
F
K
F
-------
E
D
I
H
P
Y
S
V
S
Y
S
W
DK
Q
V
E
-
D
E
D
H
M
E
V
F
P
A
G
S
S
F
P
S
T
K
L
---
I
T
L
N
R
T
G
D
F
S
M
A
A
S
Y
-
T
D
I
T
Q
L
----
P
P
--
N
--
T
P
E
Q
I
A
----
N
W
E
I
T
D
S
V
P
V
K
L
K
L
R
CDPSG
L
H
T
I
E
E
A
Y
T
I
E
D
K
T
V
K
K
D
D
L
T
I
V
A
H
T
FGLD
A
K
K
L
N
E
L
I
E
K
E
N
E
M
L
A
Q
D
K
L
V
A
E
T
E
D
R
K
-
N
T
L
E
E
Y
I
Y
T
L
R
G
K
L
E
E
E
Y
A
P
F
----
A
S
D
A
E
K
T
K
L
Q
G
M
L
N
K
A
E
E
W
L
Y
DEGFDSI
K
A
K
Y
I
A
K
Y
E
E
L
A
S
L
G
N
I
I
R
G
R
Y
L
A
K
E
E
E
K
K
Q
A
I
R
S
K
Q
27
HHSearch
55.08
17%
-60
- C4 -
2D0O
2
DDRFA_KLEOK
A:
[372-606]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
I
A
R
E
I
E
Q
K
--
L
N
I
D
V
Q
I
G
G
A
E
A
E
A
A
I
L
G
-
A
L
T
--
T
---
P
----
G
T
T
R
P
L
A
I
L
D
L
G
A
G
S
T
D
A
S
I
I
-
N
--
P
K
G
D
I
---
I
-----
A
T
---------
H
L
A
G
---------
A
G
D
M
V
T
M
I
I
------
A
R
E
L
G
L
E
D------------------
R
-------------------
Y
L
A
E
E
I
K
K
Y
P
--------------
L
A
K
V
E
S
L
F
H
L
R
H
E
D
G
S
-----------
V
Q
F
F
STP
L
P
P
AVFARV
C
V
V
K
A
D
----
E
L
V
----------
P
L
P
--
G
D
L
A
-
L
---
E
K
V
R
A
I
--
R
R
S
A
K
E
R
V
---
F
V
T
N
A
-------
L
R
A
L
R
Q
V
S
P
T
G
---
N
I
---
R
D
I
P
F
V
V
L
V
G
G
S
S
L
D
F
E
V
---
P
Q
L
V
T
----
D
A
L
A
H
Y
-
R
L
V
A
G
R
----
G
N
--
I
--------------
R
G
S
E
G
P
R
N
A
V
A
T
G
--------
L
I
L
S
W
H
K
E
F
-----------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
54.79
24%
-59
- C4 -
4CZL
1
?
A:
[150-330]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
M
V
V
D
I
G
G
G
T
T
E
V
A
V
L
-
S
--
L
S
G
I
V
---
Y
-----
S
R
---------
S
V
R
V
---------
G
G
D
K
M
D
E
A
I
I
S
Y
M
R
R
H
H
N
L
L
I
G
-------------------
E
-------------------
T
T
A
E
R
I
K
K
E
I
--------------
G
----
T
A
R
A
P
-
A
D
G
E
G
-----------
L
S
-----
I
D
V
--------
K
--
G
----
R
D
L
----------
M
Q
G
V
P
R
E
V
R
-
I
---
S
E
K
Q
A
A
D
A
L
-----
A
E
P
V
G
Q
I
V
E
A
-------
V
K
V
A
L
E
A
T
P
P
E
---
L
A
D
-
D
I
A
D
K
G
I
M
L
T
G
G
G
A
L
L
R
G
L
---
D
A
E
I
R
----
D
H
-
T
G
L
-
P
V
T
V
A
D
----
D
P
--
L
--
S
C
V
A
L
G
----
C
G
K
V
L
E
H
P
K
W
M
K
G
V
L
--------
E
S
T
L
A
---------------------------------------------------------------------------------------------------------------------------------------------
29
HHSearch
54.66
17%
-66
- C4 -
2V7Y
2
DNAK_GEOKA
A:
[123-350]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
Q
R
Q
A
T
K
D
A
G
R
I
--
A
G
L
E
V
E
R
I
I
N
E
P
T
A
A
A
L
A
-
Y
G
L
--
D
---
K
----
E
E
D
Q
T
I
L
V
Y
D
L
G
G
G
T
F
D
V
S
I
L
-
E
--
L
G
D
G
V
---
F
E
V
K
A
T
A
G
---------
D
N
H
L
---------
G
G
D
D
F
D
Q
V
I
------
I
D
Y
L
V
N
Q
-------------------
F
K
Q
E
HGIDLSKD
K
M
A
L
Q
R
L
K
D
A
A
E
K
A
K
K
E
L
--------------
S
G
V
T
Q
T
---------
Q
-----------
I
S
-----
L
P
F
--------
I
--
S
ANEN
G
P
L
----------
H
L
E
--
M
T
L
T
-
R
---
A
K
F
E
E
L
--
S
-----
A
H
---
L
V
E
R
T
-------
M
G
P
V
R
Q
A
L
Q
D
A
---
G
L
T
-
P
A
D
I
D
K
V
I
L
V
G
G
S
T
R
I
P
A
V
---
Q
E
A
I
K
----
R
E
L
-
G
K
-
E
P
H
K
---------------------------
G
V
N
P
D
E
V
V
A
I
G
--------
A
A
I
Q
G
G
V
I
A
G
E
V
K
D
V
V
L
L
D
V
T
P
-----
L
S
L
G
I
E
T
M
G
G
V
F
T
K
L
I
E
R
N
T
T
I
P
T
S
K
S
Q
-
V
F
T
T
A
A
D
N
Q
T
T
V
D
I
H
V
L
Q
G
E
R
----
P
M
A
A
D
N
K
S
L
G
R
F
Q
L
T
G
I
P
P
A
---------------------------------------------
11
PsiBlast_PDB
54.42
18%
-64
- C4 -
1DKG
-
DNAK_ECOLI
D:
[161-373]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
G
L
E
V
K
R
I
I
N
E
P
T
A
A
A
L
A
Y
G
L
D
--
K
--------
T
G
N
R
T
I
A
V
Y
D
L
G
G
G
T
F
D
I
S
I
I
-
E
--
I
D
------------
E
K
---------
T
F
E
V
LATNGDTHL
G
G
E
D
F
D
S
R
L
------
I
N
Y
L
V
E
E
-------------------
F
-------------------
K
K
D
Q
G
I
D
L
R
N
--------------
D
P
L
A
M
Q
R
L
K
E
-
A
A
E
K
A
KIELSSAQQTD
V
N
-----
L
P
Y
--------
I
--
T
----
A
D
A
TGPK------
H
M
N
--
I
K
V
T
-
R
---
A
K
L
E
S
L
--
V
-----
E
D
---
L
V
N
R
S
-------
I
E
L
L
K
V
A
L
Q
D
A
---
G
L
S
-
V
S
D
I
D
D
V
I
L
V
G
G
Q
T
R
M
P
M
V
---
Q
K
K
V
A
----
E
F
F
G
K
E
-
P
R
K
D
V
N
----
P
D
--
E
--
A
V
A
I
G
A
----
A
V
Q
G
G
V
L
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
52.83
15%
-74
- C4 -
2ZGY
1
PARM_ECOLX
A:
[137-319]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
F
T
I
K
D
V
K
V
M
P
E
S
I
P
A
G
Y
E
-
V
L
Q
--
E
---
L
----
D
E
L
D
S
L
L
I
I
D
L
G
G
T
T
L
D
I
S
Q
V
-
M
--
G
K
L
S
G
IS
K
I
-----
Y
G
---------
D
S
S
L
---------
G
V
S
L
V
T
S
A
V
------
K
D
A
L
S
L
A
RTKGS--------------
S
-------------------
Y
L
A
D
D
I
I
I
H
R
--------------
K
-------------
D
N
-----------
N
Y
-----
L
K
Q
------------------
R
------------
I
--
N
D
E
N
K
I
---
S
I
V
T
E
A
--
M
-----
N
E
---
A
L
R
K
L
-------
E
Q
R
V
L
N
T
L
N
E
--------
F
S
G
Y
T
H
V
M
V
I
G
G
G
A
E
L
--
I
---
C
D
A
V
K
----
K
H
T
-
Q
I
R
D
E
R
F
F
K
-------------------------
T
N
N
S
Q
Y
D
L
V
N
G
--------
M
Y
L
I
G
N
--------------------------------------------------------------------------------------------------------------------------------------------