@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_0937: (2015-12-19 )
MNFFDTLMGMFVEPSQKVAKSLAEHVGSFFHAQLILNTIITILFMIWAYKRVKEGDMFEFKTAMGVVVFIAFVGFINWGIKNPNDFNTYFINTIFYPSEKLAILIAQSLNDGLEIPTNTNLSPSEIFSIGNLASSAYAMIVNLWDNAFDGINMFNWLTMIPKIIMFFLVILGELLFLGLLLIIVLLVTAEIFMWSALGLIVLPLGLIPQTKGMLFSYLKKLISLTLYKPCMMLVAFFNYGIIYKVNTLIPTKHEVTQGFYGNADKMANEGKIIDVFGNVLKGDWNSYIAHSSIVGFLTIIVLGSVICFFLVKRVPDFINNIFGTSGGVGAVTEMMQKIGMTIGGAVFGGSAVMVANQVKQAYQSAGGGLAGLQAGAKAFGLGAISGGASAMANHRSVKAGVKHFVASVKSGFGFDNDKNNK
Atome Classification :
(20 SA)
---------------------------------------------------------------------------....--.....10..-----......20...---------.....30.--...--....40...--...--------------..50....---...---------.------60........70....------....80...-.....90.----------.......100.---......110......-------..120.........130.......140.......150....----...160--------.......170.......180-------.----......190.......200----------.....--....210.......220-........230.......---240--..--.....250.......260---.....--------------------------..270...------....280.----......290--...----------------------....300.......310--........320.--------------......330.......340......------.-------------------------350......-----------------.360.....-..370.......380-----.........390......------.400..--.-....410.......420---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
---------------------------------------------------------------------------M
N
F
F
--
D
T
L
M
G
MFVE-----
P
S
Q
K
V
A
K
S
L
A
E
---------
H
V
G
S
F
F
H
A
--
Q
L
I
--
L
N
T
I
I
T
I
L
F
--
M
I
W
--------------
A
Y
K
RVKEG---D
M
F
---------
E
------
F
K
T
A
M
G
V
V
V
F
I
A
F
V
G
F
------
I
N
WGIKNPN-DF
N
T
Y
F
I
N
----------
T
I
FYPSE
K
L
A
I
---
L
I
A
Q
SLND-GLEIPT-------NTN--L
S
P
S
E
I
F
S
I
G
N
L
A
S
S
A
Y
A
M
I
V
N
L
W
DNAFD
G
I
N
M
F
N
W
----
L
T
M
I
P
K
--------
I
I
M
F
F
L
V
I
L
G
E
L
L
F
L
G
L
L
L
I
-------
I
----
V
L
L
V
T
A
E
I
F
M
W
S
A
L
G
L
I
------------
V
L
PLG--LIPQTK
G
M
L
F
S
Y
L
K
K
L
--
I
S
L
T
L
Y
K
P
C
M
M
L
V
A
F
FNY---
G
I
I
--
Y
K
--
V
NTLIP
T
K
H
E
V
T
QGFYG
N
---
A
D
KMA--------------------------NEG
K
I
I
D
V
------
F
G
N
V
L
KGD----
W
N
S
Y
I
A
H
S
S
--
I
V
G
----------------------
F
L
T
I
I
V
L
G
S
V
I
C
F
F
L
V
---
K
R
V
P
D
F
I
N
N
I
FG--------------TSG
G
V
G
A
V
T
E
M
M
Q
K
I
G
M
TIG
G
A
VFG------G-------------------------
S
A
V
M
V
A
N
Q
V
-----------------
K
Q
A
Y
Q
SAGG-G
L
A
G
L
Q
A
G
A
K
AFG-------LGAISGG
A
S
A
M
AN
H
R
S
V
K
------
A
G
V
K
H
F
--
V
-
A
S
V
K
SGFGFDNDKNNK----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
Fugue
96.05
15%
-126
- C4 -
2BVL
8
TOXB_PEPDI
A:
[1-543]
---------------------------MSLVN
R
K
Q
L
E
K
M
A
NVRFRTQE
D
E
Y
V
A
I
L
D
A
L
E
E
Y
H
N
MSENT
V
V
E
K
Y
L
K
L
K
D
I
--
N
S
L
T
D
I
C
I
D
T
Y
KKS
G
R
N
K
A
L
K
K
F
K
E
---------
Y
L
V
T
E
V
L
E
L
K
N
N
N
--
L
T
P
V
E
K
N
L
H
--
F
V
W
I
GGQIN
D
T
A
I
N
Y
I
N
Q
W
K
D
V
N
S
D
Y
N
V
N
V
F
Y
D
SNAFL
I
N
T
------
L
K
K
T
V
V
E
S
A
I
N
D
T
L
E
S
------
F
R
E
N
L
N
D
P
R
F
D
Y
N
K
F
F
R
K
----------
R
M
E
I
I
Y
D
K
Q
K
N
---
F
I
N
Y
Y
K
A
Q
-
R
E
E
N
P
E
LI
I
D
D
I
V
K
T
Y
--
L
S
N
E
Y
S
K
E
I
D
E
L
N
T
Y
I
E
E
S
L
N
K
I
T
Q
N
S
G
N
D
V
R
N
F
G
E
----
F
K
N
G
E
S
--------
F
N
L
Y
E
Q
E
L
V
E
R
W
N
L
A
A
A
S
D
I
-------
L
----
R
I
S
A
L
K
E
I
------
G
G
M
------------
Y
L
D
V
D
--
M
L
P
G
I
Q
P
D
L
F
E
S
I
E
K
P
SS
V
T
V
D
F
W
E
M
T
K
L
E
A
I
M
K
Y
K
---
E
Y
I
PE
Y
T
--
S
E
H
F
D
M
L
D
E
E
V
Q
S
S
F
E
S
V
---
L
A
S
K
S
--------------------------
D
K
S
E
I
F
S
S
------
L
G
D
M
E
A
S
P
----
L
E
V
K
I
A
F
N
S
KG
I
I
N
----------------------
Q
G
L
I
S
V
K
D
S
Y
C
S
N
L
I
V
---
K
Q
I
E
N
R
Y
K
I
L
N
N
--------------
S
L
N
P
A
I
S
E
D
N
D
F
N
T
T
T
N
T
F
I
D
S
I
M
A
E
ANADN
G
-------------------------
R
F
M
M
E
L
G
K
Y
LRVGFFPDVK
T
T
I
N
L
SG
P
E
A
Y
A
A
A
Y
Q
-
D
L
L
M
F
K
E
G
S
M
N
I
H
-------
L
I
-----
E
A
D
L
R
N
F
E
I
S
K
------
T
N
I
S
Q
S
--
T
E
Q
E
M
A
S
L
W
S
F
D
D
A
R
A
K
A
Q
F
E
E
Y
K
R
N
Y
F
E
GAL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
Fugue
88.44
13%
-121
- C3 -
4O5J
3
?
A:
[27-400]
---------------------------------------------------------------------------
L
K
N
L
--
N
E
K
Y
E
Q
L
S
Q
-----
Y
L
N
Q
V
A
-
S
L
K
Q
---------
S
I
Q
N
A
N
N
I
--
E
L
V
--
N
S
S
L
N
Y
L
K
S
--
F
T
N
--------------
N
N
Y
N
S
T
T
Q
---
S
P
I
---------
F
------
N
A
V
Q
A
V
I
T
S
V
L
G
F
W
S
L
------
Y
------
A
G
-
N
Y
F
T
F
F
V
G
----------
K
K
V
D
S
G
Q
P
A
S
V
QGN
P
P
F
K
T
I
I
E
-
N
C
S
G
I
E
-------
N
C
A
--
M
D
Q
T
T
Y
D
K
M
K
K
L
A
E
D
L
Q
A
A
Q
T
N
---
S
A
T
K
G
N
N
L
C
A
L
SGCA
A
T
S
N
P
P
-------------
N
S
T
V
S
N
A
L
N
L
A
Q
Q
L
M
-------
D
----
L
I
A
N
T
K
T
A
M
M
W
K
N
I
-----------------
V
I
S
--
G
V
S
N
T
S
G
A
I
T
S
----------
T
N
Y
--------
P
T
Q
Y
---
A
V
F
--
N
N
--
I
K
A
M
I
P
I
L
Q
Q
A
V
T
L
S
Q
S
N
---
H
T
L
S
A
--------------------------
S
-----------------
L
Q
A
Q
----
A
T
G
S
Q
T
N
P
K
--
F
A
K
----------------------
D
I
Y
T
F
A
Q
N
Q
K
Q
V
I
S
Y
A
---
Q
D
I
F
N
L
F
N
S
I
P
--------------------
A
E
Q
Y
K
Y
L
E
K
A
Y
L
K
I
P
N
A
--
G
------
S
-------------------------
T
P
T
N
P
Y
R
Q
V
-----------------
V
N
L
N
Q
E
-----
V
Q
T
I
K
N
N
V
S
Y
Y
G
--------
N
R
V
D
A
A
L
S
V
A
R
D
V
Y
N
L
K
------
S
N
Q
A
E
I
--
V
-
T
A
Y
N
D
A
K
T
L
S
E
E
I
S
K
L
PH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
Fugue
85.58
15%
-86
- C2 -
2IUT
3
FTSK_PSEAE
A:
[70-477]
------------------------------------------------------------------------LPP
L
S
L
L
--
D
P
A
E
V
K
Q
K
S
-----
Y
S
P
E
S
L
E
A
M
S
R
---------
L
L
E
I
K
L
K
E
--
F
G
V
--
E
V
S
V
D
S
V
H
P
--
G
---------------------
P
V
I
---
T
R
F
---------
E
------
I
Q
P
A
A
G
V
------------------
K
V
S
R
I
S
-
N
L
A
K
D
L
A
R
----------
S
L
A
V
I
S
V
R
V
V
E
---
V
I
P
G
K
T
T
V
-
G
I
E
I
P
N
-------
E
D
R
Q
M
V
R
F
S
E
V
L
S
S
P
E
Y
D
E
H
K
S
T
V
P
L
A
L
G
H
D
-----------------------------------
I
G
G
R
P
I
I
T
D
L
A
K
M
-------
P
----
H
L
L
V
A
G
T
T
G
S
G
K
S
V
G
V
N
------------
A
M
L
L
S
--
I
L
F
K
S
T
-------
P
S
E
--
A
R
L
I
M
I
D
P
K
M
L
E
L
S
I
Y
E
----
G
I
P
--
H
L
--
L
C
P
V
V
T
D
M
K
E
A
A
N
A
L
R
W
S
---
V
A
E
M
E
--------------------------
R
R
Y
R
L
M
A
A
------
M
G
V
R
N
L
A
G
----
F
N
R
K
V
K
D
A
E
--
E
A
G
T
P
L
T
DPLFRRESPDDEPPQL
S
T
L
P
T
I
V
V
V
V
D
E
F
A
D
M
M
M
I
V
G
K
K
V
E
E
L
I
A
R
I
A
Q
KA------------
R
A
A
G
I
H
L
I
L
A
T
Q
R
P
S
V
D
V
I
T
G
L
I
K
A
------
N
-------------------------
I
P
T
R
I
A
F
Q
V
-----------------
S
S
K
I
D
S
R
T
---
I
L
D
Q
G
G
A
E
Q
L
L
G
-------
H
G
D
M
L
Y
L
P
P
G
T
G
L
P
I
R
V
H
G
A
F
V
S
D
D
E
V
H
R
V
--
V
-
E
A
W
K
L
R
G
A
P
D
Y
I
E
D
I
L
A---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
Fugue
79.41
12%
-127
* C3 *
2O1U
3
?
A:
[34-661]
------------------------------------------------------------------MMKLIINSL
Y
K
N
K
--
E
I
F
L
R
E
L
I
S
-----
N
A
S
D
A
L
D
K
I
R
L
I
S
LTDENAL
A
G
N
E
E
L
T
V
--
K
I
K
--
C
D
K
E
K
N
L
L
H
--
V
T
D
--------------
T
G
V
G
M
T
R
E
---
E
L
V
---------
K
NLGTVG
F
Y
S
A
F
L
V
A
D
K
V
I
V
T
S
K
H
NND
T
Q
H
I
W
E
S
D
S
N
E
-
F
S
V
I
A
D
P
R
GNTLG
R
G
T
T
I
T
L
V
L
K
E
E
A
S
D
Y
---
L
E
L
D
T
I
K
N
-
L
V
K
K
Y
S
-------
Q
F
I
--
N
F
P
I
Y
V
W
S
S
K
V
W
D
W
E
L
M
N
D
I
K
P
I
W
Q
R
P
S
K
E
V
E
D
D
E
Y
----
K
A
F
Y
K
S
F
SKESDDP
M
A
Y
I
H
F
T
A
E
G
E
V
T
F
K
S
I
L
F
V
P
TSAPRY
I
----
K
L
Y
V
R
R
V
F
I
T
D
D
F
H
D
M
M
PKYLNF
V
K
G
V
V
D
S
D
D
L
P
--
L
N
V
S
R
E
T
L
Q
Q
H
K
L
L
K
V
--
I
R
K
K
L
V
R
K
T
L
D
M
I
K
K
I
A
D
---
E
K
Y
--
N
D
TF
W
K
E
F
G
T
N
I
K
L
G
V
I
E
D
H
S
N
---
R
T
R
L
A
K
L
L
R
F
Q
S
SHHP
S
D
I
T
S
L
D
Q
Y
V
E
R
MKE
K
Q
D
K
I
Y
F
M
------
A
G
S
S
R
K
E
A
----
E
S
S
P
F
V
E
R
L
--
L
K
K
----------------------
G
Y
E
V
I
Y
L
T
E
P
V
D
E
Y
C
I
---
Q
A
L
P
E
F
D
G
K
R
F
Q
N
VAKEGVKFDES
E
K
T
K
E
S
R
E
A
I
E
K
E
F
E
P
L
L
N
W
M
K
D
K
A
L
K
------
D
KIE
K
A
V
V
S
QRLTESP
C
A
L
V
A
S
QYGW
S
G
N
M
E
R
I
M
K
-----------------
A
Q
A
Y
Q
T
G
K
D
I
S
T
N
Y
Y
A
S
Q
K
K
T
F
E
I
N
PRH
P
L
I
K
D
M
L
R
R
V
K
E
D
E
D
D
K
T
V
S
------
D
L
A
V
V
L
F
E
T
-
A
T
L
R
S
G
Y
L
L
P
D
T
K
A
Y
G
D
R
I
E
R
M
L
R
L
S
LNI---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
Fugue
77.81
15%
-126
- C1 -
4XMM
-
NU120_YEAST
E:
[10-1044]
AC
L
S
R
I
D
A
NLLQYYEKPEPN
N
T
V
D
L
Y
V
SGSE
Y
S
N
C
L
L
L
SNS
E
Y
I
C
Y
H
F
S
SRST
L
L
T
F
Y
P
LSDAYH
G
K
T
I
N
I
H
L
PN
A
S
M
N
--
Q
R
Y
T
L
T
I
Q
E
-----
V
E
Q
Q
L
L
V
N
V
I
L
---------
K
D
G
S
F
L
T
L
--
Q
L
P
---------
L
S
--
F
L
F
--------------
S
S
A
N
T
L
N
G
---
E
W
F
---------
H
--------------------------------
L
Q
N
P
Y
-
D
F
T
V
R
V
P
H
----------
F
L
F
Y
V
S
P
Q
F
S
V
---
V
F
L
E
D
G
G
L
L
G
L
K
K
V
D
-------
G
V
H
--
Y
E
P
L
-
L
F
N
D
N
S
Y
L
K
S
L
T
R
F
F
S
R
S
S
K
S
D
Y
D
S
V
I
S
C
K
L
----
F
H
E
--------------
R
Y
L
I
V
L
T
Q
N
C
H
L
K
I
W
D
L
-------
T
----
S
F
T
L
I
Q
D
Y
D
M
V
S
Q
S
D
S
D
------------
P
S
H
F
R
--
K
V
E
A
V
G
E
Y
L
S
L
Y
N
N
T
L
--
V
T
L
L
P
L
E
N
G
L
F
Q
M
G
T
L
L
V
----
L
T
--
Y
T
--
F
Q
N
N
I
P
T
N
-----------------
L
--------------------------
S
A
S
A
I
W
S
I
------
V
D
L
V
L
T
R
P
----
L
E
L
N
V
E
A
S
Y
---
L
N
----------------------
L
I
V
L
W
K
S
G
T
A
S
K
L
Q
I
L
---
N
V
N
D
E
S
F
K
N
Y
E
W
--------------
I
E
S
V
N
K
S
L
V
D
L
Q
S
E
H
D
L
D
I
--
V
T
K
T
------
G
-------------------------
D
V
E
R
G
F
C
N
L
-----------------
K
S
R
Y
---------
G
T
Q
I
F
E
R
A
Q
Q
-------
I
L
S
E
N
K
I
I
M
A
H
N
E
D
E
E
Y
L
------
A
N
L
E
T
I
--
L
-
R
D
V
K
T
A
F
-------
N
E
ASSITLYGD
E
I
I
L
V
N
C
FQPY
N
H
S
L
Y
K
L
N
T
T
V
E
N
W
F
Y
N
M
HSETDGS
E
L
F
K
Y
L
R
T
L
N
G
F
A
S
T
LS
N
D
V
L
R
S
I
S
K
K
F
L
D
I
I
T
GELPDSMT
T
V
E
K
F
T
D
I
F
K
N
CLENQFE
I
T
N
L
K
I
L
F
D
E
L
N
S
FD
I
P
V
V
L
N
D
L
I
NNQM
K
P
G
I
F
WKKDFISAIKFD
G
F
T
S
I
I
S
L
E
S
L
H
Q
L
L
S
I
H
Y
R
I
T
L
Q
V
L
L
T
F
V
L
F
DLDTEIF
G
Q
H
I
S
T
L
L
D
L
H
Y
K
Q
F
L
L
L
N
L
Y
R
Q
D
K
C
L
L
A
E
V
L
L
K
D
S
SEFSF
G
V
K
F
FN
Y
G
Q
L
I
A
Y
I
D
S
L
N
S
N
V
Y
NT
E
N
S
F
F
M
T
F
F
R
SS
H
K
N
I
R
F
F
L
E
N
VECE
V
Q
E
F
M
F
A
M
T
L
F
SF
D
Q
S
Y
E
I
F
Q
L
H
DI
W
K
D
L
L
C
T
F
T
V
PH
S
A
F
Y
Y
Q
L
S
L
L
F
DQ
E
F
A
L
K
C
I
S
K
S
A
E
Y
S
LQ
D
F
K
E
K
Q
H
I
H
Y
L
N
L
L
I
H
FE
V
L
D
V
L
R
L
G
H
E
CR
T
N
F
L
Q
L
L
L
Q
E
D
ID
F
F
S
T
L
L
R
L
C
N
A
H
S
DK
I
V
D
S
I
L
S
Q
N
L
R
SC
F
K
K
L
Y
C
F
R
M
L
NA
A
A
E
V
L
Y
Q
Y
I
L
MI
R
K
R
K
C
Y
L
M
V
I
N
V
L
SV
T
L
T
D
L
R
D
E
L
R
G
18
Fugue
73.71
12%
-101
* C5 *
4EEI
12
?
A:
[1-433]
-----------------------------------------------------------------MIKRYDV
A
E
I
S
K
I
W
A
D
E
N
K
Y
A
K
M
L
E
-----
V
E
L
A
I
L
E
A
L
E
D
---------
R
M
V
P
K
G
T
A
--
A
E
I
--
R
A
R
A
Q
I
R
P
E
--
R
V
D
--------------
E
I
E
K
V
T
K
H
---
D
I
I
---------
A
------
F
C
T
S
I
A
E
Q
F
T
A
E
T
G
K
F
------
F
H
F
G
V
-
T
S
S
-
D
I
I
D
S
A
L
S
----------
L
Q
I
R
D
S
M
S
Y
V
I
---
K
D
L
E
A
L
C
D
-
S
L
L
T
K
A
-------
E
E
T
--
K
E
I
I
T
M
G
R
S
H
G
M
F
A
E
P
M
S
F
----------
G
Q
K
F
L
G
A
----
Y
V
E
F
K
R
--------
R
L
K
D
L
K
D
F
Q
K
D
G
L
T
V
Q
F
S
G
A
-------
V
GNYC
I
L
T
T
E
D
E
K
K
A
A
D
I
L
G
L
P
------------
V
E
E
V
S
TQ
V
I
P
R
D
R
I
A
K
L
I
S
I
H
G
L
--
I
A
S
A
I
E
R
L
A
V
E
I
R
H
L
H
R
------------------
S
D
V
F
E
V
Y
E
G
F
K
K
N
P
I
S
T
E
N
L
T
--------------------------
G
M
A
R
M
L
R
S
------
H
V
S
I
A
L
E
N
C
VLW
H
E
R
D
I
S
H
S
S
--
A
E
R
----------------------
F
Y
L
P
D
N
F
G
I
M
V
--
Y
A
L
---
R
R
M
K
N
T
I
D
N
L
V
V
--------------
Q
R
D
I
I
E
D
R
V
R
S
T
S
A
Y
L
S
S
F
Y
L
H
F
L
V
------
A
-------------------------
N
T
P
F
M
R
E
D
C
-----------------
Y
K
I
V
Q
Q
V
E
S
-
F
S
K
K
L
Q
K
V
M
H
D
-------------
E
H
N
I
I
L
D
I
P
E
M
D
F
E
------
G
I
K
K
T
Y
--
L
-
K
E
I
D
H
V
F
D
R
S
V
K
A
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
55.07
27%
-12
- C4 -
2PTK
-
SRC_CHICK
A:
[214-287]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
--
T
S
R
T
Q
F
S
S
L
Q
Q
L
V
A
Y
Y
S
K
H
AD
G
L
C
--
H
R
--
L
T
N
V
C
P
T
S
K
P
Q
T
Q
G
L
A
K
D
---
A
W
E
I
P
--------------------------
R
E
S
L
R
L
E
V
KLGQGC
F
G
E
V
W
M
G
T
----
W
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
53.98
28%
7
- C4 -
2H8H
1
SRC_HUMAN
A:
[216-289]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
--
T
S
R
T
Q
F
N
S
L
Q
Q
L
V
A
Y
Y
S
K
HAD
G
L
C
--
H
R
--
L
T
T
V
C
P
T
S
K
P
Q
T
Q
G
L
A
K
D
---
A
W
E
I
P
--------------------------
R
E
S
L
R
L
E
V
KLGQGC
F
G
E
V
W
M
G
T
----
W
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
50.77
28%
-0
- C4 -
1FMK
-
SRC_HUMAN
A:
[214-287]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
--
T
S
R
T
Q
F
N
S
L
Q
Q
L
V
A
Y
Y
S
K
H
AD
G
L
C
--
H
R
--
L
T
T
V
C
P
T
S
K
P
Q
T
Q
G
L
A
K
D
---
A
W
E
I
P
--------------------------
R
E
S
L
R
L
E
V
KLGQGC
F
G
E
V
W
M
G
T
----
W
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
49.38
28%
-30
- C4 -
1KSW
1
SRC_HUMAN
A:
[133-206]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
--
T
S
R
T
Q
F
N
S
L
Q
Q
L
V
A
Y
Y
S
K
HAD
G
L
C
--
H
R
--
L
T
T
V
C
P
T
S
K
P
Q
T
Q
G
L
A
K
D
---
A
W
E
I
P
--------------------------
R
E
S
L
R
L
E
V
KLGQGC
F
G
E
V
W
M
G
T
----
W
N
G
T
T
R
V
A
I
--
K
T
L
----------------------
K
P
G
T
M
S
P
E
A
F
L
Q
E
A
Q
V
---
M
K
K
L
R
H
E
K
L
V
Q
L
--------------
Y
A
V
V
S
E
E
P
I
Y
I
V
G
E
Y
M
S
K
G
S
L
L
D
F
L
------
K
-------------------------
G
E
T
G
K
Y
L
R
L
-----------------
P
Q
L
V
D
M
A
A
Q
-
I
A
S
G
M
A
Y
V
E
R
M
N
Y
-------
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
------
K
V
A
D
F
G
--
L
-
A
R
L
I
E
D
N
E
Y
T
A
R
Q
G
A
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
49.24
28%
-30
- C4 -
4K11
1
SRC_HUMAN
A:
[131-204]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
--
T
S
R
T
Q
F
N
S
L
Q
Q
L
V
A
Y
Y
S
K
HAD
G
L
C
--
H
R
--
L
T
T
V
C
P
T
S
K
P
Q
T
Q
G
L
A
K
D
---
A
W
E
I
P
--------------------------
R
E
S
L
R
L
E
V
KLGQGC
F
G
E
V
W
M
G
T
----
W
N
G
T
T
R
V
A
I
--
K
T
L
----------------------
K
P
G
T
M
S
P
E
A
F
L
Q
E
A
Q
V
---
M
K
K
L
R
H
E
K
L
V
Q
L
--------------
Y
A
V
V
S
E
E
P
I
Y
I
V
G
E
Y
M
S
K
G
S
L
L
D
F
L
------
K
-------------------------
G
E
T
G
K
Y
L
R
L
-----------------
P
Q
L
V
D
M
A
A
Q
-
I
A
S
G
M
A
Y
V
E
R
M
N
Y
-------
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
------
K
V
A
D
F
G
--
L
-
A
R
L
I
E
D
N
E
Y
T
A
R
Q
G
A
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
49.12
28%
-113
* C6 *
3B7K
1
ACO12_HUMAN
A:
[197-269]
-------------------------------------------------------------------------------------
G
T
S
V
Q
-----
S
I
E
L
V
L
P
P
H
A
N
---------
H
H
G
N
T
F
G
G
--
Q
I
M
A
W
M
E
T
V
A
T
I
S
A
S
R
L
C
W
--------------
A
H
P
F
L
K
S
V
---
D
M
F
---------
K
------
F
R
G
P
S
T
V
G
D
R
L
V
F
T
A
I
------
V
N
N
T
F
Q
T
C
V
-
E
V
G
V
R
V
E
A
----------
F
D
C
Q
E
W
A
E
G
R
G
---
R
H
I
N
S
A
F
L
-
I
Y
N
A
A
D
-------
D
K
E
--
N
L
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
48.78
28%
-36
- C4 -
2SRC
1
SRC_HUMAN
A:
[133-206]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
--
T
S
R
T
Q
F
N
S
L
Q
Q
L
V
A
Y
Y
S
K
HAD
G
L
C
--
H
R
--
L
T
T
V
C
P
T
S
K
P
Q
T
Q
G
L
A
K
D
---
A
W
E
I
P
--------------------------
R
E
S
L
R
L
E
V
KLGQGC
F
G
E
V
W
M
G
T
----
W
N
G
T
T
R
V
A
I
--
K
T
L
----------------------
K
P
G
T
M
S
P
E
A
F
L
Q
E
A
Q
V
---
M
K
K
L
R
H
E
K
L
V
Q
L
--------------
Y
A
V
V
S
E
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
------
K
-------------------------
G
E
T
G
K
Y
L
R
L
-----------------
P
Q
L
V
D
M
A
A
Q
-
I
A
S
G
M
A
Y
V
E
R
M
N
Y
-------
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
------
K
V
A
D
F
G
--
L
-
A
R
L
I
E
D
N
E
Y
T
A
R
Q
G
A
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
48.38
28%
-112
- C6 -
4MOC
1
ACO12_HUMAN
A:
[176-248]
-------------------------------------------------------------------------------------
G
T
S
V
Q
-----
S
I
E
L
V
L
P
P
H
A
N
---------
H
H
G
N
T
F
G
G
--
Q
I
M
A
W
M
E
T
V
A
T
I
S
A
S
R
L
C
W
--------------
A
H
P
F
L
K
S
V
---
D
M
F
---------
K
------
F
R
G
P
S
T
V
G
D
R
L
V
F
T
A
I
------
V
N
N
T
F
Q
T
C
V
-
E
V
G
V
R
V
E
A
----------
F
D
C
Q
E
W
A
E
G
R
G
---
R
H
I
N
S
A
F
L
-
I
Y
N
A
A
D
-------
D
K
E
--
N
L
I
T
F
P
R
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
44.60
28%
-112
- C6 -
4MOB
2
ACO12_HUMAN
A:
[176-248]
-------------------------------------------------------------------------------------
G
T
S
V
Q
-----
S
I
E
L
V
L
P
P
H
A
N
---------
H
H
G
N
T
F
G
G
--
Q
I
M
A
W
M
E
T
V
A
T
I
S
A
S
R
L
C
W
--------------
A
H
P
F
L
K
S
V
---
D
M
F
---------
K
------
F
R
G
P
S
T
V
G
D
R
L
V
F
T
A
I
------
V
N
N
T
F
Q
T
C
V
-
E
V
G
V
R
V
E
A
----------
F
D
C
Q
E
W
A
E
G
R
G
---
R
H
I
N
S
A
F
L
-
I
Y
N
A
A
D
-------
D
K
E
--
N
L
I
T
F
P
R
I
Q
P
I
S
K
D
D
F
R
R
Y
R
G
A
I
A
R
K
R
I
R
L
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
40.67
28%
-15
- C4 -
1Y57
1
SRC_HUMAN
A:
[133-206]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
--
T
S
R
T
Q
F
N
S
L
Q
Q
L
V
A
Y
Y
S
K
HAD
G
L
C
--
H
R
--
L
T
T
V
C
P
T
S
K
P
Q
T
Q
G
L
A
K
D
---
A
W
E
I
P
--------------------------
R
E
S
L
R
L
E
V
KLGQGC
F
G
E
V
W
M
G
T
----
W
N
G
T
T
R
V
A
I
--
K
T
L
----------------------
K
P
G
T
M
S
P
E
A
F
L
Q
E
A
Q
V
---
M
K
K
L
R
H
E
K
L
V
Q
L
--------------
Y
A
V
V
S
E
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
------
K
-------------------------
G
E
T
G
K
Y
L
R
L
-----------------
P
Q
L
V
D
M
A
A
Q
-
I
A
S
G
M
A
Y
V
E
R
M
N
Y
-------
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
------
K
V
A
D
F
G
--
L
-
A
R
L
I
E
D
N
E
Y
T
A
R
Q
G
A
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
HHSearch
34.07
11%
240
- C4 -
1CI4
-
BAF_HUMAN
A:
[51-68]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
K
K
D
E
D
L
F
R
E
W
L
K
D
T
--
C
G
A
N
A
K
Q
S
R
D
C
F
G
C
L
R
E
W
---
C
D
A
--
F
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
Fugue
32.42
36%
380
- C5 -
2BPT
-
NUP1_YEAST
B:
[974-1012]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
S
S
F
T
-
P
S
T
V
P
N
INFS---
A
T
N
--
L
R
P
S
D
I
F
G
A
N
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
HHSearch
25.58
19%
103
- C4 -
3WU2
-
YCF12_THEVL
Y:
[7-27]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
M
I
A
M
I
G
I
A
G
P
M
------------
I
I
F
L
L
--
A
V
R
R
G
N
L
P
I
F
T
V
R
W
V
A
--
V
H
T
L
A
V
P
T
I
F
F
L
G
A
I
A
A
M
---
Q
F
I
--
Q
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
Fugue
23.30
13%
255
- C4 -
1DPJ
2
IPA3_YEAST
B:
[2-30]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
D
Q
Q
K
V
S
E
I
F
Q
S
S
---
K
E
K
L
Q
--------------------------
G
D
A
K
V
V
S
D
------
A
F
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------