@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_0974: (2015-12-19 )
MSISRRSILKKIPIALASTNVLKAVGVFEKVKSIPHATHFGPFIAKVQNGVIKDIVPQKSDYNPTMMLKAMADRVYSDSRVKYPCVRKSFLENKKNHKELRGREEFVRVSWDMALDLAAKKLKEIPKENIFNASYGGWGHAGSLHRCNNLAWRFFNTTLGGAIGTDGEYSNGAAARINPMIVGDMEVYSQQTTHEEMIKNCKVYVMWGADLFKCNRIDYFVPNHVNDSYYPKYKRAGIKFISIDPIYTETAQAFNAEWIPIRPNTDVALMLGMMHHLYTSNQYDKAFIAKYTDGFDRFLPYLLGESDKAPKTLEWASQITGVSAEKIKELADLFVSKRTFLAGNWAMQRAQHGEQPDWALIVLASMIGQVGLSGGGFGFSMHYGGNAQASSGARVVPMISQGNNAVKSVIPASRVSEAILNPDKEIDFKGKKLKLPKIKMIYNCGANLLGHEADTNELIRALRTLDCVIVHEPWWTPTAKFADIIFASTSTMERDDITFGGSYSKNVVYAMRKVVEPVYESKDDYEIFRQLALRVGGNETEQRFTESKSYMEWIKGLYEKSDGHTLKSFDQFWRDGFVEFEIPENARKFVPHAKFRQDPINNKVDTESGKIQIFFQKCADFKLADFKGHPTWFEPAEWLGSKMAEIYPFHLISPHPKYCVNSQLDNTWVRTTYKIQGRGPVMITELDANKLGIRHGEIVEVFNARGRLLAGAFVTKNIRQGVLSIQEGAWYDPEDVNTRNPRCNAGSVNTLTSSRPTSSMTQAISVNTALVNIRRLRKYELVKPYHSISTPSIIGA
Atome Classification :
(20 SA)
.........10........-20.---------.......30---......-.----.----40.......-.50......-------..60.-...-.-..---.70........80........90-..------------------------...-...100.......110.......120..----...----.---.130.......140.......150....-....160-..-.-...-...170.......180.......190-........200.......210.......220.......230-.----...--.....240.......250.......260.......270.......280----.........290...---------....300----------------------------------------------------------------------------------------------------------------------------------------...-----------......310.......320.......330....-.------..340....-...350.......360.......370.......380....-.-----.-.-390.-----..-..------------.--.--------.----400----.----------...---.-------------------.--.410...--------....--.----.-420.---...-...430--.--------------.......440.......450.....-..460------------------------------....-....470.....-..480.......490.......500.......510.......520.......530.......540...-----------.-.-------..550.....----------------------..------560---.--.-.------------.--------------------------------------------------....570...-.-------------...580------------....-..-----..590..--....--.600.......610.......620.......630.......-640------.........650....-...660..--.-.-.-..670.......680.......690.......700......--.710.......720.......730.--....-------.--.-----740.....-..750...-....760....----------------..-.770.......780.......790....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSI
S
R
R
S
I
L
K
KI
P
I
A
LAS
T
-
N
V
L
---------
K
A
V
G
V
F
E
K
V
---
K
SIPHA-T----H----
F
G
P
F
I
A
K
V
Q-N
G
V
I
K
DIVP-------QKSDY-
N
P
T
-
M
-
M
L
---
K
A
M
A
D
R
VYSDSRVK
Y
P
C
V
R
K
S
F
L
-EN------------------------KK
N
-
H
K
E
L
R
G
R
E
E
F
V
R
V
S
W
D
M
A
L
D
L
A
A
K
K
L
K
E----I
P
K
----
E
---NIFNASYGGWGHAGS
L
H
R
C
N
N
L
A
-
W
R
F
F-NTTLG---GA-I-GTD-GEYSNGAA
A
R
I
N
P
M
I
V
G
D
M
E
V
YSQQ--T
T
H
E
E
M
I
KNC
K
V
Y
V
M
WGAD
L
F
K
CN
R
I
D
Y
FVPNHVNDSYY---
P
----
K
Y
K--RAG
I
K
F
I
S
IDPIY
T
E
T
A
Q
AFNA
E
W
I
P
IRPNT
D
V
A
L
M
L
G
M
M
H
H
L
YTS------NQY
D
K
A
F
I
A
K
YTD
G
F
---------
D
R
F
L
P
------------------------------------------------------------------------------------------------------------------------------------------
Y
L
L-----------GESDKAP
K
T
L
E
W
A
S
Q
ITGV
S
A
E
K
I
K
E
L
A
D
L
F
V
S-K------R
T
F
LAG
N
W
A
-
M
Q
R
AQHGEQP
D
W
A
L
I
V
L
A
S
M
I
G
QVGLSGGG
F
G
F
S
M
H
YGGN-A-----Q-A-SS-G-----
A
R
-
V
V
------------
P
--
M
--------I----SQG----N----------
N
A
V
---
K
-------------------S--VI--
P
A
S
--------
R
V
S
E
--
A
----I-LNPD---KEI-DFKGK---K--------------LKLP
K
I
K
M
I
Y
NC
G
A
N
LLGHEA
D
T
N
E
-
L
I
R
A
-------------------------------
L
R
TL-
D
C
V
I
V
HEPWWTP-
T
A
K
F
A
D
I
I
F
ASTSTMERD
D
I
TFGGSYS
K
N
V
V
Y
A
M
R
K
V
V
E
P
V
YESKD
D
Y
E
I
F
R
Q
L
A
L
R
VGG
N
E
T
E
Q
R
F
T
-----------
E
-
S
-------
K
S
Y
M
E
W
I
K
G
L
----------------------
Y
E------KS----D--G-H------------
T
--------------------------------------------------
L
K
S
F
D
Q
F
W
RD-G-------------
F
V
E
F
E-------------IPE
N
-
A
R
-----KFVPHAK--FRQD--PINNKVDTES
G
K
I
Q
I
F
FQKCADFKLADFKGHPTWF
E
P
A
E
W
L
-
G
--------
S
K
M
A
E
I
Y
P
F
HLISPHP-
K
Y
C
VNSQL--D-N-
T
-
W
V
R
T
T
Y
K
I
QGRG
P
V
M
I
T
ELDANKLGIRH
G
E
I
V
E
V
F
NARG
R
L
--
L
A
G
A
F
V
T
K
N
I
R
Q
G
V
L
S
IQEGAWYDP--EDVN-------T--R-----NPRCNAGS-VNTLTSSR-PTSSM
T
Q
A
I
S
V----------------
N
T
-
A
L
V
N
I
R
R
L
R
K
Y
E
LVKPYHSISTPSIIGA
1
PsiBlast_PDB
98.68
42%
-77
- C7 -
1E5V
4
DSTOR_RHOCA
A:
[49-805]
---------------------------------------------
T
V
M
S
G
-
S
----
H
----
W
G
V
F
T
A
T
V
E
-
N
G
R
A
T
A
F
T
P
-------
W
E
K
D
P
-
H
P
S
-
P
-
M
L
---
A
G
V
L
D
S
I
Y
S
P
T
R
I
K
Y
P
M
V
R
R
E
F
L
-
E
K
------------------------
G
V
N
A
D
R
S
T
R
G
N
G
D
F
V
R
V
S
W
D
Q
A
L
D
L
V
A
A
E
V
K
R
----
V
E
E
T
YGP
E
---
G
V
F
G
G
S
Y
G
-
W
K
S
P
G
R
L
H
N
C
T
T
L
L
-
R
R
M
L
--
T
L
A
G
---
G
Y
-
V
-
N
G
A
-
G
D
Y
S
T
G
A
A
Q
V
I
M
P
H
V
V
G
T
L
E
V
Y
E
Q
Q
--
T
A
W
P
V
L
A
E
N
T
E
V
M
V
F
W
A
A
D
P
I
K
T
S
Q
I
G
W
V
I
P
E
H
G
A
Y
P
G
L
---
E
----
A
L
K
--
A
K
G
T
K
V
I
V
I
D
P
V
R
T
K
T
V
E
F
F
G
A
E
H
I
T
P
K
P
Q
T
D
V
A
I
M
L
G
M
A
H
T
L
V
A
E
------
D
L
Y
D
K
D
F
I
A
N
Y
T
S
G
F
---------
D
K
F
L
P
------------------------------------------------------------------------------------------------------------------------------------------
Y
L
D
-----------
G
E
T
D
S
T
P
K
T
A
E
W
A
E
G
I
S
G
V
P
A
E
T
I
K
E
L
A
R
L
F
E
S
-
K
------
R
T
M
L
A
A
G
W
S
-
M
Q
R
M
H
H
G
E
Q
A
H
W
M
L
V
T
L
A
S
M
L
G
Q
I
G
L
P
G
G
G
F
G
L
S
Y
H
Y
S
G
G
-
G
-----
T
-
P
-
S
T
-
S
-----
G
P
-
A
L
------------
A
--
G
--------
I
----
T
D
G
----------------------GA-----------------
S
--
V
I
--
P
V
A
--------
R
V
V
D
--
M
----
L
-
E
N
P
G
---
A
E
F
-
D
F
N
G
T
---
R
--------------
S
K
F
P
D
V
K
M
A
Y
W
V
G
G
N
P
F
V
H
H
Q
D
R
N
R
-
M
V
K
A
-------------------------------
W
E
K
L
-
E
T
F
V
V
H
D
F
Q
W
T
P
-
T
A
R
H
A
D
I
V
L
P
A
T
T
S
Y
E
R
N
D
I
E
T
I
G
D
Y
S
N
T
G
I
L
A
M
K
K
I
V
E
P
L
Y
E
A
R
S
D
Y
D
I
F
A
A
V
A
E
R
L
G
K
G
---
A
E
F
T
-----------
E
-
G
-------
K
D
E
M
G
W
I
K
S
F
----------------------
Y
D
D
A
A
K
Q
G
K
A
----
A
--
G
-
V
------------
Q
--------------------------------------------------
M
P
A
F
D
A
F
W
A
E
-
G
-------------
I
V
E
F
P
-------------
V
T
D
G
-
A
------
D
F
V
R
Y
A
S
--
F
R
E
D
--
P
L
L
N
P
L
G
T
P
T
G
L
I
E
I
Y
S
K
N
I
E
K
M
G
Y
D
D
C
P
A
H
P
T
W
M
E
P
L
E
R
L
-
D
--------
G
P
G
A
K
-
Y
P
L
H
I
A
A
S
H
P
-
F
N
R
L
H
S
Q
L
--
N
-
G
-
T
-
V
L
R
E
G
Y
A
V
Q
G
H
E
P
C
L
M
H
P
D
D
A
A
A
R
G
I
A
D
G
D
V
V
R
V
H
N
D
R
G
Q
I
--
L
T
G
V
K
V
T
D
A
V
M
K
G
V
I
Q
I
Y
E
G
G
W
Y
D
P
--
S
D
V
T
-------
E
--
P
-----
G
T
L
D
K
Y
G
D
-
V
N
V
L
S
A
D
I
-
G
T
S
K
L
A
Q
G
N
C
G
----------------
Q
T
-
V
L
A
E
V
E
K
Y
T
G
P
A
V
T
L
T
G
F
V
A
P
K
A
A
E
---
2
PsiBlast_PDB
98.55
42%
-74
- C7 -
1H5N
4
DSTOR_RHOCA
A:
[49-805]
---------------------------------------------
T
V
M
S
G
-
S
----
H
----
W
G
V
F
T
A
T
V
E
-
N
G
R
A
T
A
F
T
P
-------
W
E
K
D
P
-
H
P
S
-
P
-
M
L
---
A
G
V
L
D
S
I
Y
S
P
T
R
I
K
Y
P
M
V
R
R
E
F
L
-
E
K
------------------------
G
V
N
A
D
R
S
T
R
G
N
G
D
F
V
R
V
S
W
D
Q
A
L
D
L
V
A
A
E
V
K
R
----
V
E
E
T
YGP
E
---
G
V
F
G
G
S
Y
G
-
W
K
S
P
G
R
L
H
N
C
T
T
L
L
-
R
R
M
L
--
T
L
A
G
---
G
Y
-
V
-
N
G
A
-
G
D
Y
S
T
G
A
A
Q
V
I
M
P
H
V
V
G
T
L
E
V
Y
E
Q
Q
--
T
A
W
P
V
L
A
E
N
T
E
V
M
V
F
W
A
A
D
P
I
K
T
S
Q
I
G
W
V
I
P
E
H
G
A
Y
P
G
L
---
E
----
A
L
K
--
A
K
G
T
K
V
I
V
I
D
P
V
R
T
K
T
V
E
F
F
G
A
E
H
I
T
P
K
P
Q
T
D
V
A
I
M
L
G
M
A
H
T
L
V
A
E
------
D
L
Y
D
K
D
F
I
A
N
Y
T
S
G
F
---------
D
K
F
L
P
------------------------------------------------------------------------------------------------------------------------------------------
Y
L
D
-----------
G
E
T
D
S
T
P
K
T
A
E
W
A
E
G
I
S
G
V
P
A
E
T
I
K
E
L
A
R
L
F
E
S
-
K
------
R
T
M
L
A
A
G
W
S
-
M
Q
R
M
H
H
G
E
Q
A
H
W
M
L
V
T
L
A
S
M
L
G
Q
I
G
L
P
G
G
G
F
G
L
S
Y
H
Y
S
G
G
-
G
-----
T
-
P
-
S
T
-
S
-----
G
P
-
A
L
------------
A
--
G
--------
I
----
T
D
G
----------------------GA-----------------
S
--
V
I
--
P
V
A
--------
R
V
V
D
--
M
----
L
-
E
N
P
G
---
A
E
F
-
D
F
N
G
T
---
R
--------------
S
K
F
P
D
V
K
M
A
Y
W
V
G
G
N
P
F
V
H
H
Q
D
R
N
R
-
M
V
K
A
-------------------------------
W
E
K
L
-
E
T
F
V
V
H
D
F
Q
W
T
P
-
T
A
R
H
A
D
I
V
L
P
A
T
T
S
Y
E
R
N
D
I
E
T
I
G
D
Y
S
N
T
G
I
L
A
M
K
K
I
V
E
P
L
Y
E
A
R
S
D
Y
D
I
F
A
A
V
A
E
R
L
G
K
G
---
A
E
F
T
-----------
E
-
G
-------
K
D
E
M
G
W
I
K
S
F
----------------------
Y
D
D
A
A
K
Q
G
K
A
----
A
--
G
-
V
------------
Q
--------------------------------------------------
M
P
A
F
D
A
F
W
A
E
-
G
-------------
I
V
E
F
P
-------------
V
T
D
G
-
A
------
D
F
V
R
Y
A
S
--
F
R
E
D
--
P
L
L
N
P
L
G
T
P
T
G
L
I
E
I
Y
S
K
N
I
E
K
M
G
Y
D
D
C
P
A
H
P
T
W
M
E
P
L
E
R
L
-
D
--------
G
P
G
A
K
-
Y
P
L
H
I
A
A
S
H
P
-
F
N
R
L
H
S
Q
L
--
N
-
G
-
T
-
V
L
R
E
G
Y
A
V
Q
G
H
E
P
C
L
M
H
P
D
D
A
A
A
R
G
I
A
D
G
D
V
V
R
V
H
N
D
R
G
Q
I
--
L
T
G
V
K
V
T
D
A
V
M
K
G
V
I
Q
I
Y
E
G
G
W
Y
D
P
--
S
D
V
T
-------
E
--
P
-----
G
T
L
D
K
Y
G
D
-
V
N
V
L
S
A
D
I
-
G
T
S
K
L
A
Q
G
N
C
G
----------------
Q
T
-
V
L
A
E
V
E
K
Y
T
G
P
A
V
T
L
T
G
F
V
A
P
K
A
A
E
---
8
PsiBlast_PDB
98.54
42%
-77
- C7 -
1E18
6
DSTOR_RHOCA
A:
[49-805]
---------------------------------------------
T
V
M
S
G
-
S
----
H
----
W
G
V
F
T
A
T
V
E
-
N
G
R
A
T
A
F
T
P
-------
W
E
K
D
P
-
H
P
S
-
P
-
M
L
---
A
G
V
L
D
S
I
Y
S
P
T
R
I
K
Y
P
M
V
R
R
E
F
L
-
E
K
------------------------
G
V
N
A
D
R
S
T
R
G
N
G
D
F
V
R
V
S
W
D
Q
A
L
D
L
V
A
A
E
V
K
R
----
V
E
E
T
YGP
Q
---
G
V
F
G
G
S
Y
G
-
W
K
S
P
G
R
L
H
N
C
T
T
L
L
-
R
R
M
L
--
T
L
A
G
---
G
Y
-
V
-
N
G
A
-
G
D
Y
S
T
G
A
A
Q
V
I
M
P
H
V
V
G
T
L
E
V
Y
E
Q
Q
--
T
A
W
P
V
L
A
E
N
T
E
V
M
V
F
W
A
A
D
P
I
K
T
S
Q
I
G
W
V
I
P
E
H
G
A
Y
P
G
L
---
E
----
A
L
K
--
A
K
G
T
K
V
I
V
I
D
P
V
R
T
K
T
V
E
F
F
G
A
E
H
I
T
P
K
P
Q
T
D
V
A
I
M
L
G
M
A
H
T
L
V
A
E
------
D
L
Y
D
K
D
F
I
A
N
Y
T
S
G
F
---------
D
K
F
L
P
------------------------------------------------------------------------------------------------------------------------------------------
Y
L
D
-----------
G
E
T
D
S
T
P
K
T
A
E
W
A
E
G
I
S
G
V
P
A
E
T
I
K
E
L
A
R
L
F
E
S
-
K
------
R
T
M
L
A
A
G
W
S
-
M
Q
R
M
H
H
G
E
Q
A
H
W
M
L
V
T
L
A
S
M
L
G
Q
I
G
L
P
G
G
G
F
G
L
S
Y
H
Y
S
G
G
-
G
-----
T
-
P
-
S
T
-
S
-----
G
P
-
A
L
------------
A
--
G
--------
I
----
T
D
G
----
G
----------
A
A
T
---
K
GPEWLAASGA---------
S
--
V
I
--
P
V
A
--------
R
V
V
D
--
M
----
L
-
E
N
P
G
---
A
E
F
-
D
F
N
G
T
---
R
--------------
S
K
F
P
D
V
K
M
A
Y
W
V
G
G
N
P
F
V
H
H
Q
D
R
N
R
-
M
V
K
A
-------------------------------
W
E
K
L
-
E
T
F
V
V
H
D
F
Q
W
T
P
-
T
A
R
H
A
D
I
V
L
P
A
T
T
S
Y
E
R
N
D
I
E
T
I
G
D
Y
S
N
T
G
I
L
A
M
K
K
I
V
E
P
L
Y
E
A
R
S
D
Y
D
I
F
A
A
V
A
E
R
L
G
K
G
---
K
E
F
T
-----------
E
-
G
-------
K
D
E
M
G
W
I
K
S
F
----------------------
Y
D
D
A
A
K
Q
G
K
A
----
A
--
G
-
V
------------
E
--------------------------------------------------
M
P
A
F
D
A
F
W
A
E
-
G
-------------
I
V
E
F
P
-------------
V
T
D
G
-
A
------
D
F
V
R
Y
A
S
--
F
R
E
D
--
P
L
L
N
P
L
G
T
P
T
G
L
I
E
I
Y
S
K
N
I
E
K
M
G
Y
D
D
C
P
A
H
P
T
W
M
E
P
L
E
R
L
-
D
--------
G
P
G
A
K
-
Y
P
L
H
I
A
A
S
H
P
-
F
N
R
L
H
S
Q
L
--
N
-
G
-
T
-
V
L
R
E
G
Y
A
V
Q
G
H
E
P
C
L
M
H
P
D
D
A
A
A
R
G
I
A
D
G
D
V
V
R
V
H
N
D
R
G
Q
I
--
L
T
G
V
K
V
T
D
A
V
M
K
G
V
I
Q
I
Y
E
G
G
W
Y
D
P
--
S
D
V
T
-------
E
--
P
-----
G
T
L
D
K
Y
G
D
-
V
N
V
L
S
A
D
I
-
G
T
S
K
L
A
Q
G
N
C
G
----------------
Q
T
-
V
L
A
E
V
E
K
Y
T
G
P
A
V
T
L
T
G
F
V
A
P
K
A
A
E
---
3
PsiBlast_PDB
98.48
42%
-75
- C7 -
1DMR
5
DSTOR_RHOCA
A:
[49-805]
---------------------------------------------
T
V
M
S
G
-
S
----
H
----
W
G
V
F
T
A
T
V
E
-
N
G
R
A
T
A
F
T
P
-------
W
E
K
D
P
-
H
P
S
-
P
-
M
L
---
A
G
V
L
D
S
I
Y
S
P
T
R
I
K
Y
P
M
V
R
R
E
F
L
-
E
K
------------------------
G
V
N
A
D
R
S
T
R
G
N
G
D
F
V
R
V
S
W
D
Q
A
L
D
L
V
A
A
E
V
K
R
----
V
E
E
T
YGP
E
---
G
V
F
G
G
S
Y
G
-
W
K
S
P
G
R
L
H
N
C
T
T
L
L
-
R
R
M
L
--
T
L
A
G
---
G
Y
-
V
-
N
G
A
-
G
D
Y
S
T
G
A
A
Q
V
I
M
P
H
V
V
G
T
L
E
V
Y
E
Q
Q
--
T
A
W
P
V
L
A
E
N
T
E
V
M
V
F
W
A
A
D
P
I
K
T
S
Q
I
G
W
V
I
P
E
H
G
A
Y
P
G
L
---
E
----
A
L
K
--
A
K
G
T
K
V
I
V
I
D
P
V
R
T
K
T
V
E
F
F
G
A
E
H
I
T
P
K
P
Q
T
D
V
A
I
M
L
G
M
A
H
T
L
V
A
E
------
D
L
Y
D
K
D
F
I
A
N
Y
T
S
G
F
---------
D
K
F
L
P
------------------------------------------------------------------------------------------------------------------------------------------
Y
L
D
-----------
G
E
T
D
S
T
P
K
T
A
E
W
A
E
G
I
S
G
V
P
A
E
T
I
K
E
L
A
R
L
F
E
S
-
K
------
R
T
M
L
A
A
G
W
S
-
M
Q
R
M
H
H
G
E
Q
A
H
W
M
L
V
T
L
A
S
M
L
G
Q
I
G
L
P
G
G
G
F
G
L
S
Y
H
Y
S
G
G
-
G
-----
T
-
P
-
S
T
-
S
-----
G
P
-
A
L
------------
A
--
G
--------
I
----
T
D
G
----
G
----------
A
A
T
---
K
GPEWLAASGA---------
S
--
V
I
--
P
V
A
--------
R
V
V
D
--
M
----
L
-
E
N
P
G
---
A
E
F
-
D
F
N
G
T
---
R
--------------
S
K
F
P
D
V
K
M
A
Y
W
V
G
G
N
P
F
V
H
H
Q
D
R
N
R
-
M
V
K
A
-------------------------------
W
E
K
L
-
E
T
F
V
V
H
D
F
Q
W
T
P
-
T
A
R
H
A
D
I
V
L
P
A
T
T
S
Y
E
R
N
D
I
E
T
I
G
D
Y
S
N
T
G
I
L
A
M
K
K
I
V
E
P
L
Y
E
A
R
S
D
Y
D
I
F
A
A
V
A
E
R
L
G
K
G
---
A
E
F
T
-----------
E
-
G
-------
K
D
E
M
G
W
I
K
S
F
----------------------
Y
D
D
A
A
K
Q
G
K
A
----
A
--
G
-
V
------------
Q
--------------------------------------------------
M
P
A
F
D
A
F
W
A
E
-
G
-------------
I
V
E
F
P
-------------
V
T
D
G
-
A
------
D
F
V
R
Y
A
S
--
F
R
E
D
--
P
L
L
N
P
L
G
T
P
T
G
L
I
E
I
Y
S
K
N
I
E
K
M
G
Y
D
D
C
P
A
H
P
T
W
M
E
P
L
E
R
L
-
D
--------
G
P
G
A
K
-
Y
P
L
H
I
A
A
S
H
P
-
F
N
R
L
H
S
Q
L
--
N
-
G
-
T
-
V
L
R
E
G
Y
A
V
Q
G
H
E
P
C
L
M
H
P
D
D
A
A
A
R
G
I
A
D
G
D
V
V
R
V
H
N
D
R
G
Q
I
--
L
T
G
V
K
V
T
D
A
V
M
K
G
V
I
Q
I
Y
E
G
G
W
Y
D
P
--
S
D
V
T
-------
E
--
P
-----
G
T
L
D
K
Y
G
D
-
V
N
V
L
S
A
D
I
-
G
T
S
K
L
A
Q
G
N
C
G
----------------
Q
T
-
V
L
A
E
V
E
K
Y
T
G
P
A
V
T
L
T
G
F
V
A
P
K
A
A
E
---
7
PsiBlast_PDB
98.46
42%
-77
- C7 -
1E61
4
DSTOR_RHOCA
A:
[49-805]
---------------------------------------------
T
V
M
S
G
-
S
----
H
----
W
G
V
F
T
A
T
V
E
-
N
G
R
A
T
A
F
T
P
-------
W
E
K
D
P
-
H
P
S
-
P
-
M
L
---
A
G
V
L
D
S
I
Y
S
P
T
R
I
K
Y
P
M
V
R
R
E
F
L
-
E
K
------------------------
G
V
N
A
D
R
S
T
R
G
N
G
D
F
V
R
V
S
W
D
Q
A
L
D
L
V
A
A
E
V
K
R
----
V
E
E
T
YGP
E
---
G
V
F
G
G
S
Y
G
-
W
K
S
P
G
R
L
H
N
C
T
T
L
L
-
R
R
M
L
--
T
L
A
G
---
G
Y
-
V
-
N
G
A
-
G
D
Y
S
T
G
A
A
Q
V
I
M
P
H
V
V
G
T
L
E
V
Y
E
Q
Q
--
T
A
W
P
V
L
A
E
N
T
E
V
M
V
F
W
A
A
D
P
I
K
T
S
Q
I
G
W
V
I
P
E
H
G
A
Y
P
G
L
---
E
----
A
L
K
--
A
K
G
T
K
V
I
V
I
D
P
V
R
T
K
T
V
E
F
F
G
A
E
H
I
T
P
K
P
Q
T
D
V
A
I
M
L
G
M
A
H
T
L
V
A
E
------
D
L
Y
D
K
D
F
I
A
N
Y
T
S
G
F
---------
D
K
F
L
P
------------------------------------------------------------------------------------------------------------------------------------------
Y
L
D
-----------
G
E
T
D
S
T
P
K
T
A
E
W
A
E
G
I
S
G
V
P
A
E
T
I
K
E
L
A
R
L
F
E
S
-
K
------
R
T
M
L
A
A
G
W
S
-
M
Q
R
M
H
H
G
E
Q
A
H
W
M
L
V
T
L
A
S
M
L
G
Q
I
G
L
P
G
G
G
F
G
L
S
Y
H
Y
S
G
G
-
G
-----
T
-
P
-
S
T
-
S
-----
G
P
-
A
L
------------
A
--
G
--------
I
----
T
D
G
----
G
-----------------GA-----------------
S
--
V
I
--
P
V
A
--------
R
V
V
D
--
M
----
L
-
E
N
P
G
---
A
E
F
-
D
F
N
G
T
---
R
--------------
S
K
F
P
D
V
K
M
A
Y
W
V
G
G
N
P
F
V
H
H
Q
D
R
N
R
-
M
V
K
A
-------------------------------
W
E
K
L
-
E
T
F
V
V
H
D
F
Q
W
T
P
-
T
A
R
H
A
D
I
V
L
P
A
T
T
S
Y
E
R
N
D
I
E
T
I
G
D
Y
S
N
T
G
I
L
A
M
K
K
I
V
E
P
L
Y
E
A
R
S
D
Y
D
I
F
A
A
V
A
E
R
L
G
K
G
---
A
E
F
T
-----------
E
-
G
-------
K
D
E
M
G
W
I
K
S
F
----------------------
Y
D
D
A
A
K
Q
G
K
A
----
A
--
G
-
V
------------
E
--------------------------------------------------
M
P
A
F
D
A
F
W
A
E
-
G
-------------
I
V
E
F
P
-------------
V
T
D
G
-
A
------
D
F
V
R
Y
A
S
--
F
R
E
D
--
P
L
L
N
P
L
G
T
P
T
G
L
I
E
I
Y
S
K
N
I
E
K
M
G
Y
D
D
C
P
A
H
P
T
W
M
E
P
L
E
R
L
-
D
--------
G
P
G
A
K
-
Y
P
L
H
I
A
A
S
H
P
-
F
N
R
L
H
S
Q
L
--
N
-
G
-
T
-
V
L
R
E
G
Y
A
V
Q
G
H
E
P
C
L
M
H
P
D
D
A
A
A
R
G
I
A
D
G
D
V
V
R
V
H
N
D
R
G
Q
I
--
L
T
G
V
K
V
T
D
A
V
M
K
G
V
I
Q
I
Y
E
G
G
W
Y
D
P
--
S
D
V
T
-------
E
--
P
-----
G
T
L
D
K
Y
G
D
-
V
N
V
L
S
A
D
I
-
G
T
S
K
L
A
Q
G
N
C
G
----------------
Q
T
-
V
L
A
E
V
E
K
Y
T
G
P
A
V
T
L
T
G
F
V
A
P
K
A
A
E
---
22
PsiBlast_CBE
98.45
42%
-75
- C7 -
1E5V
4
DSTOR_RHOCA
C:
[49-805]
---------------------------------------------
T
V
M
S
G
-
S
----
H
----
W
G
V
F
T
A
T
V
E
-
N
G
R
A
T
A
F
T
P
-------
W
E
K
D
P
-
H
P
S
-
P
-
M
L
---
A
G
V
L
D
S
I
Y
S
P
T
R
I
K
Y
P
M
V
R
R
E
F
L
-
E
K
------------------------
G
V
N
A
D
R
S
T
R
G
N
G
D
F
V
R
V
S
W
D
Q
A
L
D
L
V
A
A
E
V
K
R
----
V
E
E
TYGP
E
---
G
V
F
G
G
S
Y
G
-
W
K
S
P
G
R
L
H
N
C
T
T
L
L
-
R
R
M
L
--
T
L
A
G
---
G
Y
-
V
-
N
G
A
-
G
D
Y
S
T
G
A
A
Q
V
I
M
P
H
V
V
G
T
L
E
V
Y
E
Q
Q
--
T
A
W
P
V
L
A
E
N
T
E
V
M
V
F
W
A
A
D
P
I
K
T
S
Q
I
G
W
V
I
P
E
H
G
A
Y
P
G
L
---
E
----
A
L
K
--
A
K
G
T
K
V
I
V
I
D
P
V
R
T
K
T
V
E
F
F
G
A
E
H
I
T
P
K
P
Q
T
D
V
A
I
M
L
G
M
A
H
T
L
V
A
E
------
D
L
Y
D
K
D
F
I
A
N
Y
T
S
G
F
---------
D
K
F
L
P
------------------------------------------------------------------------------------------------------------------------------------------
Y
L
D
-----------
G
E
T
D
S
T
P
K
T
A
E
W
A
E
G
I
S
G
V
P
A
E
T
I
K
E
L
A
R
L
F
E
S
-
K
------
R
T
M
L
A
A
G
W
S
-
M
Q
R
M
H
H
G
E
Q
A
H
W
M
L
V
T
L
A
S
M
L
G
Q
I
G
L
P
G
G
G
F
G
L
S
Y
H
Y
S
G
G
-
G
-----
T
-
P
-
S
T
-
S
-----
G
P
-
A
L
------------
A
--
G
--------
I
----
T
D
G
----------------------GA-----------------
S
--
V
I
--
P
V
A
--------
R
V
V
D
--
M
----
L
-
E
N
P
G
---
A
E
F
-
D
F
N
G
T
---
R
--------------
S
K
F
P
D
V
K
M
A
Y
W
V
G
G
N
P
F
V
H
H
Q
D
R
N
R
-
M
V
K
A
-------------------------------
W
E
K
L
-
E
T
F
V
V
H
D
F
Q
W
T
P
-
T
A
R
H
A
D
I
V
L
P
A
T
T
S
Y
E
R
N
D
I
E
T
I
G
D
Y
S
N
T
G
I
L
A
M
K
K
I
V
E
P
L
Y
E
A
R
S
D
Y
D
I
F
A
A
V
A
E
R
L
G
K
G
---
A
E
F
T
-----------
E
-
G
-------
K
D
E
M
G
W
I
K
S
F
----------------------
Y
D
DAAKQG
K
A
----
A
--
G
-
V
------------
Q
--------------------------------------------------
M
P
A
F
D
A
F
W
A
E
-
G
-------------
I
V
E
F
P
-------------
V
T
D
G
-
A
------
D
F
V
R
Y
A
S
--
F
R
E
D
--
P
L
L
N
P
L
G
T
P
T
G
L
I
E
I
Y
S
K
N
I
E
K
M
G
Y
D
D
C
P
A
H
P
T
W
M
E
P
L
E
R
L
-
D
--------
G
P
G
A
K
-
Y
P
L
H
I
A
A
S
H
P
-
F
N
R
L
H
S
Q
L
--
N
-
G
-
T
-
V
L
R
E
G
Y
A
V
Q
G
H
E
P
C
L
M
H
P
D
D
A
A
A
R
G
I
A
D
G
D
V
V
R
V
H
N
D
R
G
Q
I
--
L
T
G
V
K
V
T
D
A
V
M
K
G
V
I
Q
I
Y
E
G
G
W
Y
D
P
--
S
D
V
T
-------
E
--
P
-----
G
T
L
D
K
Y
G
D
-
V
N
V
L
S
A
D
I
-
G
T
S
K
L
A
Q
G
N
C
G
----------------
Q
T
-
V
L
A
E
V
E
K
Y
T
G
P
A
V
T
L
T
G
F
V
A
P
K
A
A
E
---
4
PsiBlast_PDB
98.37
42%
-77
- C7 -
2DMR
5
DSTOR_RHOCA
A:
[49-805]
---------------------------------------------
T
V
M
S
G
-
S
----
H
----
W
G
V
F
T
A
T
V
E
-
N
G
R
A
T
A
F
T
P
-------
W
E
K
D
P
-
H
P
S
-
P
-
M
L
---
A
G
V
L
D
S
I
Y
S
P
T
R
I
K
Y
P
M
V
R
R
E
F
L
-
E
K
------------------------
G
V
N
A
D
R
S
T
R
G
N
G
D
F
V
R
V
S
W
D
Q
A
L
D
L
V
A
A
E
V
K
R
----
V
E
E
T
YGP
E
---
G
V
F
G
G
S
Y
G
-
W
K
S
P
G
R
L
H
N
C
T
T
L
L
-
R
R
M
L
--
T
L
A
G
---
G
Y
-
V
-
N
G
A
-
G
D
Y
S
T
G
A
A
Q
V
I
M
P
H
V
V
G
T
L
E
V
Y
E
Q
Q
--
T
A
W
P
V
L
A
E
N
T
E
V
M
V
F
W
A
A
D
P
I
K
T
S
Q
I
G
W
V
I
P
E
H
G
A
Y
P
G
L
---
E
----
A
L
K
--
A
K
G
T
K
V
I
V
I
D
P
V
R
T
K
T
V
E
F
F
G
A
E
H
I
T
P
K
P
Q
T
D
V
A
I
M
L
G
M
A
H
T
L
V
A
E
------
D
L
Y
D
K
D
F
I
A
N
Y
T
S
G
F
---------
D
K
F
L
P
------------------------------------------------------------------------------------------------------------------------------------------
Y
L
D
-----------
G
E
T
D
S
T
P
K
T
A
E
W
A
E
G
I
S
G
V
P
A
E
T
I
K
E
L
A
R
L
F
E
S
-
K
------
R
T
M
L
A
A
G
W
S
-
M
Q
R
M
H
H
G
E
Q
A
H
W
M
L
V
T
L
A
S
M
L
G
Q
I
G
L
P
G
G
G
F
G
L
S
Y
H
Y
S
G
G
-
G
-----
T
-
P
-
S
T
-
S
-----
G
P
-
A
L
------------
A
--
G
--------
I
----
T
D
G
----
G
----------
A
A
T
---
K
GA-----------------
S
--
V
I
--
P
V
A
--------
R
V
V
D
--
M
----
L
-
E
N
P
G
---
A
E
F
-
D
F
N
G
T
---
R
--------------
S
K
F
P
D
V
K
M
A
Y
W
V
G
G
N
P
F
V
H
H
Q
D
R
N
R
-
M
V
K
A
-------------------------------
W
E
K
L
-
E
T
F
V
V
H
D
F
Q
W
T
P
-
T
A
R
H
A
D
I
V
L
P
A
T
T
S
Y
E
R
N
D
I
E
T
I
G
D
Y
S
N
T
G
I
L
A
M
K
K
I
V
E
P
L
Y
E
A
R
S
D
Y
D
I
F
A
A
V
A
E
R
L
G
K
G
---
A
E
F
T
-----------
E
-
G
-------
K
D
E
M
G
W
I
K
S
F
----------------------
Y
D
D
A
A
K
Q
G
K
A
----
A
--
G
-
V
------------
Q
--------------------------------------------------
M
P
A
F
D
A
F
W
A
E
-
G
-------------
I
V
E
F
P
-------------
V
T
D
G
-
A
------
D
F
V
R
Y
A
S
--
F
R
E
D
--
P
L
L
N
P
L
G
T
P
T
G
L
I
E
I
Y
S
K
N
I
E
K
M
G
Y
D
D
C
P
A
H
P
T
W
M
E
P
L
E
R
L
-
D
--------
G
P
G
A
K
-
Y
P
L
H
I
A
A
S
H
P
-
F
N
R
L
H
S
Q
L
--
N
-
G
-
T
-
V
L
R
E
G
Y
A
V
Q
G
H
E
P
C
L
M
H
P
D
D
A
A
A
R
G
I
A
D
G
D
V
V
R
V
H
N
D
R
G
Q
I
--
L
T
G
V
K
V
T
D
A
V
M
K
G
V
I
Q
I
Y
E
G
G
W
Y
D
P
--
S
D
V
T
-------
E
--
P
-----
G
T
L
D
K
Y
G
D
-
V
N
V
L
S
A
D
I
-
G
T
S
K
L
A
Q
G
N
C
G
----------------
Q
T
-
V
L
A
E
V
E
K
Y
T
G
P
A
V
T
L
T
G
F
V
A
P
K
A
A
E
---
23
PsiBlast_CBE
98.32
42%
-76
- C7 -
1E61
4
DSTOR_RHOCA
C:
[49-805]
---------------------------------------------
T
V
M
S
G
-
S
----
H
----
W
G
V
F
T
A
T
V
E
-
N
G
R
A
T
A
F
T
P
-------
W
E
K
D
P
-
H
P
S
-
P
-
M
L
---
A
G
V
L
D
S
I
Y
S
P
T
R
I
K
Y
P
M
V
R
R
E
F
L
-
E
K
------------------------
G
V
N
A
D
R
S
T
R
G
N
G
D
F
V
R
V
S
W
D
Q
A
L
D
L
V
A
A
E
V
K
R
----
V
E
E
TYGP
E
---
G
V
F
G
G
S
Y
G
-
W
K
S
P
G
R
L
H
N
C
T
T
L
L
-
R
R
M
L
--
T
L
A
G
---
G
Y
-
V
-
N
G
A
-
G
D
Y
S
T
G
A
A
Q
V
I
M
P
H
V
V
G
T
L
E
V
Y
E
Q
Q
--
T
A
W
P
V
L
A
E
N
T
E
V
M
V
F
W
A
A
D
P
I
K
T
S
Q
I
G
W
V
I
P
E
H
G
A
Y
P
G
L
---
E
----
A
L
K
--
A
K
G
T
K
V
I
V
I
D
P
V
R
T
K
T
V
E
F
F
G
A
E
H
I
T
P
K
P
Q
T
D
V
A
I
M
L
G
M
A
H
T
L
V
A
E
------
D
L
Y
D
K
D
F
I
A
N
Y
T
S
G
F
---------
D
K
F
L
P
------------------------------------------------------------------------------------------------------------------------------------------
Y
L
D
-----------
G
E
T
D
S
T
P
K
T
A
E
W
A
E
G
I
S
G
V
P
A
E
T
I
K
E
L
A
R
L
F
E
S
-
K
------
R
T
M
L
A
A
G
W
S
-
M
Q
R
M
H
H
G
E
Q
A
H
W
M
L
V
T
L
A
S
M
L
G
Q
I
G
L
P
G
G
G
F
G
L
S
Y
H
Y
S
G
G
-
G
-----
T
-
P
-
S
T
-
S
-----
G
P
-
A
L
------------
A
--
G
--------
I
----
T
D
G
----
G
-----------------GA-----------------
S
--
V
I
--
P
V
A
--------
R
V
V
D
--
M
----
L
-
E
N
P
G
---
A
E
F
-
D
F
N
G
T
---
R
--------------
S
K
F
P
D
V
K
M
A
Y
W
V
G
G
N
P
F
V
H
H
Q
D
R
N
R
-
M
V
K
A
-------------------------------
W
E
K
L
-
E
T
F
V
V
H
D
F
Q
W
T
P
-
T
A
R
H
A
D
I
V
L
P
A
T
T
S
Y
E
R
N
D
I
E
T
I
G
D
Y
S
N
T
G
I
L
A
M
K
K
I
V
E
P
L
Y
E
A
R
S
D
Y
D
I
F
A
A
V
A
E
R
L
G
K
G
---
A
E
F
T
-----------
E
-
G
-------
K
D
E
M
G
W
I
K
S
F
----------------------
Y
D
DAAKQG
K
A
----
A
--
G
-
V
------------
E
--------------------------------------------------
M
P
A
F
D
A
F
W
A
E
-
G
-------------
I
V
E
F
P
-------------
V
T
D
G
-
A
------
D
F
V
R
Y
A
S
--
F
R
E
D
--
P
L
L
N
P
L
G
T
P
T
G
L
I
E
I
Y
S
K
N
I
E
K
M
G
Y
D
D
C
P
A
H
P
T
W
M
E
P
L
E
R
L
-
D
--------
G
P
G
A
K
-
Y
P
L
H
I
A
A
S
H
P
-
F
N
R
L
H
S
Q
L
--
N
-
G
-
T
-
V
L
R
E
G
Y
A
V
Q
G
H
E
P
C
L
M
H
P
D
D
A
A
A
R
G
I
A
D
G
D
V
V
R
V
H
N
D
R
G
Q
I
--
L
T
G
V
K
V
T
D
A
V
M
K
G
V
I
Q
I
Y
E
G
G
W
Y
D
P
--
S
D
V
T
-------
E
--
P
-----
G
T
L
D
K
Y
G
D
-
V
N
V
L
S
A
D
I
-
G
T
S
K
L
A
Q
G
N
C
G
----------------
Q
T
-
V
L
A
E
V
E
K
Y
T
G
P
A
V
T
L
T
G
F
V
A
P
K
A
A
E
---
10
PsiBlast_PDB
98.24
42%
-75
- C7 -
4DMR
5
DSTOR_RHOCA
A:
[49-805]
---------------------------------------------
T
V
M
S
G
-
S
----
H
----
W
G
V
F
T
A
T
V
E
-
N
G
R
A
T
A
F
T
P
-------
W
E
K
D
P
-
H
P
S
-
P
-
M
L
---
A
G
V
L
D
S
I
Y
S
P
T
R
I
K
Y
P
M
V
R
R
E
F
L
-
E
K
------------------------
G
V
N
A
D
R
S
T
R
G
N
G
D
F
V
R
V
S
W
D
Q
A
L
D
L
V
A
A
E
V
K
R
----
V
E
E
T
YGP
S
---
G
V
F
G
G
S
Y
G
-
W
K
S
P
G
R
L
H
N
C
T
T
L
L
-
R
R
M
L
--
T
L
A
G
---
G
Y
-
V
-
N
G
A
-
G
D
Y
S
T
G
A
A
Q
V
I
M
P
H
V
V
G
T
L
E
V
Y
E
Q
Q
--
T
A
W
P
V
L
A
E
N
T
E
V
M
V
F
W
A
A
D
P
I
K
T
S
Q
I
G
W
V
I
P
E
H
G
A
Y
P
G
L
---
E
----
A
L
K
--
A
K
G
T
K
V
I
V
I
D
P
V
R
T
K
T
V
E
F
F
G
A
E
H
I
T
P
K
P
Q
T
D
V
A
I
M
L
G
M
A
H
T
L
V
A
E
------
D
L
Y
D
K
D
F
I
A
N
Y
T
S
G
F
---------
D
K
F
L
P
------------------------------------------------------------------------------------------------------------------------------------------
Y
L
D
-----------
G
E
T
D
S
T
P
K
T
A
E
W
A
E
G
I
S
G
V
P
A
E
T
I
K
E
L
A
R
L
F
E
S
-
K
------
R
T
M
L
A
A
G
W
S
-
M
Q
R
M
H
H
G
E
Q
A
H
W
M
L
V
T
L
A
S
M
L
G
Q
I
G
L
P
G
G
G
F
G
L
S
Y
H
Y
S
G
G
-
G
-----
T
-
P
-
S
T
-
S
-----
G
P
-
A
L
------------
A
--
G
--------
I
----
T
D
G
----
G
----------------
K
GPEWLAAS--------------
V
I
--
P
V
A
--------
R
V
V
D
--
M
----
L
-
E
N
P
G
---
A
E
F
-
D
F
N
G
T
---
R
--------------
S
K
F
P
D
V
K
M
A
Y
W
V
G
G
N
P
F
V
H
H
Q
D
R
N
R
-
M
V
K
A
-------------------------------
W
E
K
L
-
E
T
F
V
V
H
D
F
Q
W
T
P
-
T
A
R
H
A
D
I
V
L
P
A
T
T
S
Y
E
R
N
D
I
E
T
I
G
D
Y
S
N
T
G
I
L
A
M
K
K
I
V
E
P
L
Y
E
A
R
S
D
Y
D
I
F
A
A
V
A
E
R
L
G
K
G
---
A
E
F
T
-----------
E
-
G
-------
K
D
E
M
G
W
I
K
S
F
----------------------
Y
D
D
A
A
K
Q
G
K
A
----
A
--
G
-
V
------------
Q
--------------------------------------------------
M
P
A
F
D
A
F
W
A
E
-
G
-------------
I
V
E
F
P
-------------
V
T
D
G
-
A
------
D
F
V
R
Y
A
S
--
F
R
E
D
--
P
L
L
N
P
L
G
T
P
T
G
L
I
E
I
Y
S
K
N
I
E
K
M
G
Y
D
D
C
P
A
H
P
T
W
M
E
P
L
E
R
L
-
D
--------
G
P
G
A
K
-
Y
P
L
H
I
A
A
S
H
P
-
F
N
R
L
H
S
Q
L
--
N
-
G
-
T
-
V
L
R
E
G
Y
A
V
Q
G
H
E
P
C
L
M
H
P
D
D
A
A
A
R
G
I
A
D
G
D
V
V
R
V
H
N
D
R
G
Q
I
--
L
T
G
V
K
V
T
D
A
V
M
K
G
V
I
Q
I
Y
E
G
G
W
Y
D
P
--
S
D
V
T
-------
E
--
P
-----
G
T
L
D
K
Y
G
D
-
V
N
V
L
S
A
D
I
-
G
T
S
K
L
A
Q
G
N
C
G
----------------
Q
T
-
V
L
A
E
V
E
K
Y
T
G
P
A
V
T
L
T
G
F
V
A
P
K
A
A
E
---
21
PsiBlast_CBE
98.14
42%
-73
- C7 -
1H5N
4
DSTOR_RHOCA
C:
[49-805]
---------------------------------------------
T
V
M
S
G
-
S
----
H
----
W
G
V
F
T
A
T
V
E
-
N
G
R
A
T
A
F
T
P
-------
W
E
K
D
P
-
H
P
S
-
P
-
M
L
---
A
G
V
L
D
S
I
Y
S
P
T
R
I
K
Y
P
M
V
R
R
E
F
L
-
E
K
------------------------
G
V
N
A
D
R
S
T
R
G
N
G
D
F
V
R
V
S
W
D
Q
A
L
D
L
V
A
A
E
V
K
R
----
V
E
E
TYGP
E
---
G
V
F
G
G
S
Y
G
-
W
K
S
P
G
R
L
H
N
C
T
T
L
L
-
R
R
M
L
--
T
L
A
G
---
G
Y
-
V
-
N
G
A
-
G
D
Y
S
T
G
A
A
Q
V
I
M
P
H
V
V
G
T
L
E
V
Y
E
Q
Q
--
T
A
W
P
V
L
A
E
N
T
E
V
M
V
F
W
A
A
D
P
I
K
T
S
Q
I
G
W
V
I
P
E
H
G
A
Y
P
G
L
---
E
----
A
L
K
--
A
K
G
T
K
V
I
V
I
D
P
V
R
T
K
T
V
E
F
F
G
A
E
H
I
T
P
K
P
Q
T
D
V
A
I
M
L
G
M
A
H
T
L
V
A
E
------
D
L
Y
D
K
D
F
I
A
N
Y
T
S
G
F
---------
D
K
F
L
P
------------------------------------------------------------------------------------------------------------------------------------------
Y
L
D
-----------
G
E
T
D
S
T
P
K
T
A
E
W
A
E
G
I
S
G
V
P
A
E
T
I
K
E
L
A
R
L
F
E
S
-
K
------
R
T
M
L
A
A
G
W
S
-
M
Q
R
M
H
H
G
E
Q
A
H
W
M
L
V
T
L
A
S
M
L
G
Q
I
G
L
P
G
G
G
F
G
L
S
Y
H
Y
S
G
G
-
G
-----
T
-
P
-
S
T
-
S
-----
G
P
-
A
L
------------
A
--
G
--------
I
----
T
D
G
----------------------GA-----------------
S
--
V
I
--
P
V
A
--------
R
V
V
D
--
M
----
L
-
E
N
P
G
---
A
E
F
-
D
F
N
G
T
---
R
--------------
S
K
F
P
D
V
K
M
A
Y
W
V
G
G
N
P
F
V
H
H
Q
D
R
N
R
-
M
V
K
A
-------------------------------
W
E
K
L
-
E
T
F
V
V
H
D
F
Q
W
T
P
-
T
A
R
H
A
D
I
V
L
P
A
T
T
S
Y
E
R
N
D
I
E
T
I
G
D
Y
S
N
T
G
I
L
A
M
K
K
I
V
E
P
L
Y
E
A
R
S
D
Y
D
I
F
A
A
V
A
E
R
L
G
K
G
---
A
E
F
T
-----------
E
-
G
-------
K
D
E
M
G
W
I
K
S
F
----------------------
Y
D
DAAKQG
K
A
----
A
--
G
-
V
------------
Q
--------------------------------------------------
M
P
A
F
D
A
F
W
A
E
-
G
-------------
I
V
E
F
P
-------------
V
T
D
G
-
A
------
D
F
V
R
Y
A
S
--
F
R
E
D
--
P
L
L
N
P
L
G
T
P
T
G
L
I
E
I
Y
S
K
N
I
E
K
M
G
Y
D
D
C
P
A
H
P
T
W
M
E
P
L
E
R
L
-
D
--------
G
P
G
A
K
-
Y
P
L
H
I
A
A
S
H
P
-
F
N
R
L
H
S
Q
L
--
N
-
G
-
T
-
V
L
R
E
G
Y
A
V
Q
G
H
E
P
C
L
M
H
P
D
D
A
A
A
R
G
I
A
D
G
D
V
V
R
V
H
N
D
R
G
Q
I
--
L
T
G
V
K
V
T
D
A
V
M
K
G
V
I
Q
I
Y
E
G
G
W
Y
D
P
--
S
D
V
T
-------
E
--
P
-----
G
T
L
D
K
Y
G
D
-
V
N
V
L
S
A
D
I
-
G
T
S
K
L
A
Q
G
N
C
G
----------------
Q
T
-
V
L
A
E
V
E
K
Y
T
G
P
A
V
T
L
T
G
F
V
A
P
K
A
A
E
---
5
PsiBlast_PDB
98.14
42%
-74
- C7 -
3DMR
5
DSTOR_RHOCA
A:
[49-805]
---------------------------------------------
T
V
M
S
G
-
S
----
H
----
W
G
V
F
T
A
T
V
E
-
N
G
R
A
T
A
F
T
P
-------
W
E
K
D
P
-
H
P
S
-
P
-
M
L
---
A
G
V
L
D
S
I
Y
S
P
T
R
I
K
Y
P
M
V
R
R
E
F
L
-
E
K
------------------------
G
V
N
A
D
R
S
T
R
G
N
G
D
F
V
R
V
S
W
D
Q
A
L
D
L
V
A
A
E
V
K
R
----
V
E
E
T
YGP
E
---
G
V
F
G
G
S
Y
G
-
W
K
S
P
G
R
L
H
N
C
T
T
L
L
-
R
R
M
L
--
T
L
A
G
---
G
Y
-
V
-
N
G
A
-
G
D
Y
S
T
G
A
A
Q
V
I
M
P
H
V
V
G
T
L
E
V
Y
E
Q
Q
--
T
A
W
P
V
L
A
E
N
T
E
V
M
V
F
W
A
A
D
P
I
K
T
S
Q
I
G
W
V
I
P
E
H
G
A
Y
P
G
L
---
E
----
A
L
K
--
A
K
G
T
K
V
I
V
I
D
P
V
R
T
K
T
V
E
F
F
G
A
E
H
I
T
P
K
P
Q
T
D
V
A
I
M
L
G
M
A
H
T
L
V
A
E
------
D
L
Y
D
K
D
F
I
A
N
Y
T
S
G
F
---------
D
K
F
L
P
------------------------------------------------------------------------------------------------------------------------------------------
Y
L
D
-----------
G
E
T
D
S
T
P
K
T
A
E
W
A
E
G
I
S
G
V
P
A
E
T
I
K
E
L
A
R
L
F
E
S
-
K
------
R
T
M
L
A
A
G
W
S
-
M
Q
R
M
H
H
G
E
Q
A
H
W
M
L
V
T
L
A
S
M
L
G
Q
I
G
L
P
G
G
G
F
G
L
S
Y
H
Y
S
G
G
-
G
-----
T
-
P
-
S
T
-
S
-----
G
P
-
A
L
------------
A
--
G
--------
I
----
T
D
G
----
G
----------
A
A
T
---
K
GPEWLAASGA---------
S
--
V
I
--
P
V
A
--------
R
V
V
D
--
M
----
L
-
E
N
P
G
---
A
E
F
-
D
F
N
G
T
---
R
--------------
S
K
F
P
D
V
K
M
A
Y
W
V
G
G
N
P
F
V
H
H
Q
D
R
N
R
-
M
V
K
A
-------------------------------
W
E
K
L
-
E
T
F
V
V
H
D
F
Q
W
T
P
-
T
A
R
H
A
D
I
V
L
P
A
T
T
S
Y
E
R
N
D
I
E
T
I
G
D
Y
S
N
T
G
I
L
A
M
K
K
I
V
E
P
L
Y
E
A
R
S
D
Y
D
I
F
A
A
V
A
E
R
L
G
K
G
---
A
E
F
T
-----------
E
-
G
-------
K
D
E
M
G
W
I
K
S
F
----------------------
Y
D
D
A
A
K
Q
G
K
A
----
A
--
G
-
V
------------
Q
--------------------------------------------------
M
P
A
F
D
A
F
W
A
E
-
G
-------------
I
V
E
F
P
-------------
V
T
D
G
-
A
------
D
F
V
R
Y
A
S
--
F
R
E
D
--
P
L
L
N
P
L
G
T
P
T
G
L
I
E
I
Y
S
K
N
I
E
K
M
G
Y
D
D
C
P
A
H
P
T
W
M
E
P
L
E
R
L
-
D
--------
G
P
G
A
K
-
Y
P
L
H
I
A
A
S
H
P
-
F
N
R
L
H
S
Q
L
--
N
-
G
-
T
-
V
L
R
E
G
Y
A
V
Q
G
H
E
P
C
L
M
H
P
D
D
A
A
A
R
G
I
A
D
G
D
V
V
R
V
H
N
D
R
G
Q
I
--
L
T
G
V
K
V
T
D
A
V
M
K
G
V
I
Q
I
Y
E
G
G
W
Y
D
P
--
S
D
V
T
-------
E
--
P
-----
G
T
L
D
K
Y
G
D
-
V
N
V
L
S
A
D
I
-
G
T
S
K
L
A
Q
G
N
C
G
----------------
Q
T
-
V
L
A
E
V
E
K
Y
T
G
P
A
V
T
L
T
G
F
V
A
P
K
A
A
E
---
6
PsiBlast_PDB
97.95
42%
-73
- C7 -
1E60
5
DSTOR_RHOCA
A:
[49-805]
---------------------------------------------
T
V
M
S
G
-
S
----
H
----
W
G
V
F
T
A
T
V
E
-
N
G
R
A
T
A
F
T
P
-------
W
E
K
D
P
-
H
P
S
-
P
-
M
L
---
A
G
V
L
D
S
I
Y
S
P
T
R
I
K
Y
P
M
V
R
R
E
F
L
-
E
K
------------------------
G
V
N
A
D
R
S
T
R
G
N
G
D
F
V
R
V
S
W
D
Q
A
L
D
L
V
A
A
E
V
K
R
----
V
E
E
T
YGP
E
---
G
V
F
G
G
S
Y
G
-
W
K
S
P
G
R
L
H
N
C
T
T
L
L
-
R
R
M
L
--
T
L
A
G
---
G
Y
-
V
-
N
G
A
-
G
D
Y
S
T
G
A
A
Q
V
I
M
P
H
V
V
G
T
L
E
V
Y
E
Q
Q
--
T
A
W
P
V
L
A
E
N
T
E
V
M
V
F
W
A
A
D
P
I
K
T
S
Q
I
G
W
V
I
P
E
H
G
A
Y
P
G
L
---
E
----
A
L
K
--
A
K
G
T
K
V
I
V
I
D
P
V
R
T
K
T
V
E
F
F
G
A
E
H
I
T
P
K
P
Q
T
D
V
A
I
M
L
G
M
A
H
T
L
V
A
E
------
D
L
Y
D
K
D
F
I
A
N
Y
T
S
G
F
---------
D
K
F
L
P
------------------------------------------------------------------------------------------------------------------------------------------
Y
L
D
-----------
G
E
T
D
S
T
P
K
T
A
E
W
A
E
G
I
S
G
V
P
A
E
T
I
K
E
L
A
R
L
F
E
S
-
K
------
R
T
M
L
A
A
G
W
S
-
M
Q
R
M
H
H
G
E
Q
A
H
W
M
L
V
T
L
A
S
M
L
G
Q
I
G
L
P
G
G
G
F
G
L
S
Y
H
Y
S
G
G
-
G
-----
T
-
P
-
S
T
-
S
-----
G
P
-
A
L
------------
A
--
G
--------
I
----
T
D
G
----
G
----------
A
A
T
---
K
GPEWLAASGA---------
S
--
V
I
--
P
V
A
--------
R
V
V
D
--
M
----
L
-
E
N
P
G
---
A
E
F
-
D
F
N
G
T
---
R
--------------
S
K
F
P
D
V
K
M
A
Y
W
V
G
G
N
P
F
V
H
H
Q
D
R
N
R
-
M
V
K
A
-------------------------------
W
E
K
L
-
E
T
F
V
V
H
D
F
Q
W
T
P
-
T
A
R
H
A
D
I
V
L
P
A
T
T
S
Y
E
R
N
D
I
E
T
I
G
D
Y
S
N
T
G
I
L
A
M
K
K
I
V
E
P
L
Y
E
A
R
S
D
Y
D
I
F
A
A
V
A
E
R
L
G
K
G
---
A
E
F
T
-----------
E
-
G
-------
K
D
E
M
G
W
I
K
S
F
----------------------
Y
D
D
A
A
K
Q
G
K
A
----
A
--
G
-
V
------------
E
--------------------------------------------------
M
P
A
F
D
A
F
W
A
E
-
G
-------------
I
V
E
F
P
-------------
V
T
D
G
-
A
------
D
F
V
R
Y
A
S
--
F
R
E
D
--
P
L
L
N
P
L
G
T
P
T
G
L
I
E
I
Y
S
K
N
I
E
K
M
G
Y
D
D
C
P
A
H
P
T
W
M
E
P
L
E
R
L
-
D
--------
G
P
G
A
K
-
Y
P
L
H
I
A
A
S
H
P
-
F
N
R
L
H
S
Q
L
--
N
-
G
-
T
-
V
L
R
E
G
Y
A
V
Q
G
H
E
P
C
L
M
H
P
D
D
A
A
A
R
G
I
A
D
G
D
V
V
R
V
H
N
D
R
G
Q
I
--
L
T
G
V
K
V
T
D
A
V
M
K
G
V
I
Q
I
Y
E
G
G
W
Y
D
P
--
S
D
V
T
-------
E
--
P
-----
G
T
L
D
K
Y
G
D
-
V
N
V
L
S
A
D
I
-
G
T
S
K
L
A
Q
G
N
C
G
----------------
Q
T
-
V
L
A
E
V
E
K
Y
T
G
P
A
V
T
L
T
G
F
V
A
P
K
A
A
E
---
9
PsiBlast_PDB
97.89
42%
-74
- C7 -
1DMS
3
DSTOR_RHOCA
A:
[7-763]
---------------------------------------------
T
V
M
S
G
-
S
----
H
----
W
G
V
F
T
A
T
V
E
-
N
G
R
A
T
A
F
T
P
-------
W
E
K
D
P
-
H
P
T
-
P
-
M
L
---
E
G
V
L
D
S
I
Y
S
P
T
R
I
K
Y
P
M
V
R
R
E
F
L
-
E
K
------------------------
G
V
N
A
D
R
S
T
R
G
N
G
D
F
V
R
V
S
W
D
Q
A
L
D
L
V
A
A
E
V
K
R
----
V
E
E
T
YGP
Q
---
G
V
F
G
G
S
Y
G
-
W
K
S
P
G
R
L
H
N
C
T
T
L
L
-
R
R
M
L
--
T
L
A
G
---
G
Y
-
V
-
N
G
A
-
G
D
Y
S
T
G
A
A
Q
V
I
M
P
H
V
V
G
T
L
E
V
Y
E
Q
Q
--
T
A
W
P
V
L
A
E
N
T
E
V
M
V
F
W
A
A
D
P
I
K
T
S
Q
I
G
W
V
I
P
E
H
G
A
Y
P
G
L
---
E
----
A
L
K
--
A
K
G
T
K
V
I
V
I
D
P
V
R
T
K
T
V
E
F
F
G
A
D
H
V
T
P
K
P
Q
T
D
V
A
I
M
L
G
M
A
H
T
L
V
A
E
------
D
L
Y
D
K
D
F
I
A
N
Y
T
S
G
F
---------
D
K
F
L
P
------------------------------------------------------------------------------------------------------------------------------------------
Y
L
M
-----------
G
E
T
D
S
T
P
K
T
A
E
W
A
S
D
I
S
G
V
P
A
E
T
I
K
E
L
A
R
L
F
K
S
-
K
------
R
T
M
L
A
A
G
W
S
-
M
Q
R
M
H
H
G
E
Q
A
H
W
M
L
V
T
L
A
S
M
L
G
Q
I
G
L
P
G
G
G
F
G
L
S
Y
H
Y
S
G
G
-
G
-----
T
-
P
-
S
S
-
S
-----
G
P
-
A
L
------------
S
--
G
--------
I
----
T
D
G
----------------------GA-----------------
S
--
V
I
--
P
V
A
--------
R
V
V
D
--
M
----
L
-
E
N
P
G
---
A
E
F
-
D
F
N
G
T
---
R
--------------
S
K
F
P
D
V
K
M
A
Y
W
V
G
G
N
P
F
V
H
H
Q
D
R
N
R
-
M
V
K
A
-------------------------------
W
E
K
L
-
E
T
F
I
V
H
D
F
Q
W
T
P
-
T
A
R
H
A
D
I
V
L
P
A
T
T
S
Y
E
R
N
D
I
E
T
I
G
D
Y
S
N
T
G
I
L
A
M
K
K
I
V
E
P
L
Y
E
A
R
S
D
Y
D
I
F
A
A
V
A
E
R
L
G
K
G
---
K
E
F
T
-----------
E
-
G
-------
K
D
E
M
G
W
I
K
S
F
----------------------
Y
D
D
A
A
K
Q
G
K
A
----
G
--
G
-
V
------------
E
--------------------------------------------------
M
P
A
F
D
A
F
W
A
E
-
G
-------------
I
V
E
F
P
-------------
V
T
D
G
-
A
------
D
F
V
R
Y
A
S
--
F
R
E
D
--
P
L
L
N
P
L
G
T
P
T
G
L
I
E
I
Y
S
K
N
I
E
K
M
G
Y
D
D
C
P
A
H
P
T
W
M
E
P
L
E
R
L
-
D
--------
G
P
G
A
K
-
Y
P
L
H
I
A
A
S
H
P
-
F
N
R
L
H
S
Q
L
--
N
-
G
-
T
-
V
L
R
E
G
Y
A
V
Q
G
H
E
P
C
L
M
H
P
D
D
A
A
A
R
G
I
A
D
G
D
V
V
R
V
H
N
D
R
G
Q
I
--
L
T
G
V
K
V
T
D
A
V
M
K
G
V
I
Q
I
Y
E
G
G
W
Y
D
P
--
S
D
V
T
-------
E
--
A
-----
G
T
L
D
K
Y
G
D
-
V
N
V
L
S
A
D
I
-
G
T
S
K
L
A
Q
G
N
C
G
----------------
Q
T
-
V
L
A
E
V
E
K
Y
T
G
P
A
V
T
L
T
G
F
V
A
P
K
A
A
E
---
24
PsiBlast_CBE
97.74
42%
-74
- C7 -
1E60
5
DSTOR_RHOCA
C:
[49-805]
---------------------------------------------
T
V
M
S
G
-
S
----
H
----
W
G
V
F
T
A
T
V
E
-
N
G
R
A
T
A
F
T
P
-------
W
E
K
D
P
-
H
P
S
-
P
-
M
L
---
A
G
V
L
D
S
I
Y
S
P
T
R
I
K
Y
P
M
V
R
R
E
F
L
-
E
K
------------------------
G
V
N
A
D
R
S
T
R
G
N
G
D
F
V
R
V
S
W
D
Q
A
L
D
L
V
A
A
E
V
K
R
----
V
E
E
TYGP
E
---
G
V
F
G
G
S
Y
G
-
W
K
S
P
G
R
L
H
N
C
T
T
L
L
-
R
R
M
L
--
T
L
A
G
---
G
Y
-
V
-
N
G
A
-
G
D
Y
S
T
G
A
A
Q
V
I
M
P
H
V
V
G
T
L
E
V
Y
E
Q
Q
--
T
A
W
P
V
L
A
E
N
T
E
V
M
V
F
W
A
A
D
P
I
K
T
S
Q
I
G
W
V
I
P
E
H
G
A
Y
P
G
L
---
E
----
A
L
K
--
A
K
G
T
K
V
I
V
I
D
P
V
R
T
K
T
V
E
F
F
G
A
E
H
I
T
P
K
P
Q
T
D
V
A
I
M
L
G
M
A
H
T
L
V
A
E
------
D
L
Y
D
K
D
F
I
A
N
Y
T
S
G
F
---------
D
K
F
L
P
------------------------------------------------------------------------------------------------------------------------------------------
Y
L
D
-----------
G
E
T
D
S
T
P
K
T
A
E
W
A
E
G
I
S
G
V
P
A
E
T
I
K
E
L
A
R
L
F
E
S
-
K
------
R
T
M
L
A
A
G
W
S
-
M
Q
R
M
H
H
G
E
Q
A
H
W
M
L
V
T
L
A
S
M
L
G
Q
I
G
L
P
G
G
G
F
G
L
S
Y
H
Y
S
G
G
-
G
-----
T
-
P
-
S
T
-
S
-----
G
P
-
A
L
------------
A
--
G
--------
I
----
T
D
G
----
G
-----------------AASGA--------------
S
--
V
I
--
P
V
A
--------
R
V
V
D
--
M
----
L
-
E
N
P
G
---
A
E
F
-
D
F
N
G
T
---
R
--------------
S
K
F
P
D
V
K
M
A
Y
W
V
G
G
N
P
F
V
H
H
Q
D
R
N
R
-
M
V
K
A
-------------------------------
W
E
K
L
-
E
T
F
V
V
H
D
F
Q
W
T
P
-
T
A
R
H
A
D
I
V
L
P
A
T
T
S
Y
E
R
N
D
I
E
T
I
G
D
Y
S
N
T
G
I
L
A
M
K
K
I
V
E
P
L
Y
E
A
R
S
D
Y
D
I
F
A
A
V
A
E
R
L
G
K
G
---
A
E
F
T
-----------
E
-
G
-------
K
D
E
M
G
W
I
K
S
F
----------------------
Y
D
DAAKQG
K
A
----
A
--
G
-
V
------------
E
--------------------------------------------------
M
P
A
F
D
A
F
W
A
E
-
G
-------------
I
V
E
F
P
-------------
V
T
D
G
-
A
------
D
F
V
R
Y
A
S
--
F
R
E
D
--
P
L
L
N
P
L
G
T
P
T
G
L
I
E
I
Y
S
K
N
I
E
K
M
G
Y
D
D
C
P
A
H
P
T
W
M
E
P
L
E
R
L
-
D
--------
G
P
G
A
K
-
Y
P
L
H
I
A
A
S
H
P
-
F
N
R
L
H
S
Q
L
--
N
-
G
-
T
-
V
L
R
E
G
Y
A
V
Q
G
H
E
P
C
L
M
H
P
D
D
A
A
A
R
G
I
A
D
G
D
V
V
R
V
H
N
D
R
G
Q
I
--
L
T
G
V
K
V
T
D
A
V
M
K
G
V
I
Q
I
Y
E
G
G
W
Y
D
P
--
S
D
V
T
-------
E
--
P
-----
G
T
L
D
K
Y
G
D
-
V
N
V
L
S
A
D
I
-
G
T
S
K
L
A
Q
G
N
C
G
----------------
Q
T
-
V
L
A
E
V
E
K
Y
T
G
P
A
V
T
L
T
G
F
V
A
P
K
A
A
E
---
43
HHSearch
93.08
37%
-68
- C7 -
1TMO
3
TORA_SHEMA
A:
[36-818]
--------------------------------------
N
E
D
---
E
W
L
T
T
G
-
S
----
H
----
F
G
A
F
K
M
K
R
K
-
N
G
V
I
A
E
V
K
P
-------
F
D
L
D
K
-
Y
P
T
-
D
-
M
I
---
N
G
I
R
G
M
V
Y
N
P
S
R
V
R
Y
P
M
V
R
L
D
F
L
-
L
K
G-----------------------
H
K
S
-
N
T
H
Q
R
G
D
F
R
F
V
R
V
T
W
D
K
A
L
T
L
F
K
H
S
L
D
E
V
Q
T
Q
Y
G
P
----
S
---
G
L
H
A
G
-
Q
T
G
W
R
A
T
G
Q
L
---
H
S
S
T
-
S
H
M
Q
-
R
-
A
V
G
M
H
G
N
Y
-
V
-
K
K
I
-
G
D
Y
S
T
G
A
G
Q
T
I
L
P
Y
V
L
G
S
T
E
V
Y
A
Q
G
--
T
S
W
P
L
I
L
E
H
S
D
T
I
V
L
W
S
N
D
P
Y
K
N
L
Q
V
G
W
N
A
E
T
H
E
S
F
A
Y
L
A
Q
L
K
----
E
K
V
K
-
Q
G
K
I
R
V
I
S
I
D
P
V
V
T
K
T
Q
A
Y
L
G
C
E
Q
L
Y
V
N
P
Q
T
D
V
T
L
M
L
A
I
A
H
E
M
I
S
K
------
K
L
Y
D
D
K
F
I
Q
G
Y
S
L
G
F
---------
E
E
F
V
P
------------------------------------------------------------------------------------------------------------------------------------------
Y
V
M
-----------
G
T
K
D
G
V
A
K
T
P
E
W
A
A
P
I
C
G
V
E
A
H
V
I
R
D
L
A
K
T
L
V
K
-
G
------
R
T
Q
F
M
M
G
W
C
-
I
Q
R
Q
Q
H
G
E
Q
P
Y
W
M
A
A
V
L
A
T
M
I
G
Q
I
G
L
P
G
G
G
I
S
Y
G
H
H
Y
S
S
I
-
G
-----
V
-
P
-
S
S
-
G
-----
A
A
-
A
P
------------
G
--
A
--------
F
----
P
R
N
LDEN
Q
KPLFDSSDF-
K
G
A
---
S
-------------------
S
--
T
I
--
P
V
A
--------
R
W
I
D
--
A
----
I
-
L
E
P
G
---
K
T
I
-
D
A
N
G
S
---
K
--------------
V
V
Y
P
D
I
K
M
M
I
F
S
G
N
N
P
W
N
H
H
Q
D
R
N
R
-
M
K
Q
A
-------------------------------
F
H
K
L
-
E
C
V
V
T
V
D
V
N
W
T
A
-
T
C
R
F
S
D
I
V
L
P
A
C
T
T
Y
E
R
N
D
I
D
V
Y
G
A
Y
A
N
R
G
I
L
A
M
Q
K
M
V
E
P
L
F
D
S
L
S
D
F
E
I
F
T
R
F
A
A
V
L
G
K
---
E
K
E
Y
T
-----------
R
-
N
-------
M
G
E
M
E
W
L
E
T
L
----------------------
Y
N
------
E
C
K
A
A
N
A
--
G
K
F
------------
E
--------------------------------------------------
M
P
D
F
A
T
F
W
K
Q
-
G
-------------
Y
V
H
F
G
-------------
D
G
----
E
-----
V
W
T
R
H
A
D
--
F
R
N
D
--
P
E
I
N
P
L
G
T
P
S
G
L
I
E
I
F
S
R
K
I
D
Q
F
G
Y
D
D
C
K
G
H
P
T
W
M
E
K
T
E
R
S
-
H
G-------
G
P
G
S
D
K
H
P
I
W
L
Q
S
C
H
P
-
D
K
R
L
H
S
Q
M
--
C
-
E
S
R
-
E
Y
R
E
T
Y
A
V
N
G
R
E
P
V
Y
I
S
P
V
D
A
K
A
R
G
I
K
D
G
D
I
V
R
V
F
N
D
R
G
Q
L
--
L
A
G
A
V
V
S
D
N
F
P
K
G
I
V
R
I
H
E
G
A
W
Y
G
P
--
V
G
K
D
GSTEGGA
E
--
V
-----
G
A
L
C
S
Y
G
D
-
P
N
T
L
T
L
D
I
-
G
T
S
K
L
A
Q
A
C
S
A
----------------
Y
T
-
C
L
V
E
F
E
K
Y
Q
G
K
V
P
K
V
S
S
F
D
G
P
I
E
V
E
I
--
11
PsiBlast_PDB
92.70
36%
-72
- C7 -
1TMO
3
TORA_SHEMA
A:
[36-812]
-----------------------------------------N
E
D
E
W
L
T
T
G
-
S
----
H
----
F
G
A
F
K
M
K
R
K
-
N
G
V
I
A
E
V
K
P
-------
F
D
L
D
K
-
Y
P
T
-
D
-
M
I
---
N
G
I
R
G
M
V
Y
N
P
S
R
V
R
Y
P
M
V
R
L
D
F
L
L
K
G
------------------------
H
K
S
-
N
T
H
Q
R
G
D
F
R
F
V
R
V
T
W
D
K
A
L
T
L
F
K
H
S
L
D
E
----
V
Q
T
----
Q
YGP
S
G
L
H
A
G
Q
T
G
W
R
A
T
G
Q
L
H
S
S
T
S
H
M
-
Q
R
A
V
-
G
M
H
-
G
---
N
Y
-
V
-
K
K
I
-
G
D
Y
S
T
G
A
G
Q
T
I
L
P
Y
V
L
G
S
T
E
V
Y
A
Q
G
--
T
S
W
P
L
I
L
E
H
S
D
T
I
V
L
W
S
N
D
P
Y
K
N
L
Q
V
G
W
N
A
E
T
H
E
S
F
A
Y
L
---
A
Q
L
K
E
K
V
K
--
Q
G
K
I
R
V
I
S
I
D
P
V
V
T
K
T
Q
A
Y
L
G
C
E
Q
L
Y
V
N
P
Q
T
D
V
T
L
M
L
A
I
A
H
E
M
I
S
K
------
K
L
Y
D
D
K
F
I
Q
G
Y
S
L
G
F
---------
E
E
F
V
P
------------------------------------------------------------------------------------------------------------------------------------------
Y
V
M
-----------
G
T
K
D
G
V
A
K
T
P
E
W
A
A
P
I
C
G
V
E
A
H
V
I
R
D
L
A
K
T
L
V
K
-
G
------
R
T
Q
F
M
M
G
W
C
-
I
Q
R
Q
Q
H
G
E
Q
P
Y
W
M
A
A
V
L
A
T
M
I
G
Q
I
G
L
P
G
G
G
I
S
Y
G
H
H
Y
S
S
I
-
G
-----
V
-
P
-
S
S
-
G
-----
A
A
-
A
P
G
A
F
P
RNLDENQK
P
--
L
--------
F
----
D
S
S
----
D
F---------
K
G
A
---
S
-------------------
S
--
T
I
--
P
V
A
--------
R
W
I
D
--
A
----
I
-
L
E
P
G
---
K
T
I
-
D
A
N
G
S
---
K
--------------
V
V
Y
P
D
I
K
M
M
I
F
S
G
N
N
P
W
N
H
H
Q
D
R
N
R
-
M
K
Q
A
-------------------------------
F
H
K
L
-
E
C
V
V
T
V
D
V
N
W
T
A
-
T
C
R
F
S
D
I
V
L
P
A
C
T
T
Y
E
R
N
D
I
D
V
Y
G
A
Y
A
N
R
G
I
L
A
M
Q
K
M
V
E
P
L
F
D
S
L
S
D
F
E
I
F
T
R
F
A
A
V
L
G
---
K
E
K
E
Y
T
-----------
R
-
N
-------
M
G
E
M
E
W
L
E
T
L
----------------------
Y
N
------
E
C
----
K
--
A
-
A
------------
N
AGK
F
E
---------------------------------------------
M
P
D
F
A
T
F
W
K
Q
-
G
-------------
Y
V
H
F
----------------
G
D
-
G
E
-----
V
W
T
R
H
A
D
--
F
R
N
D
--
P
E
I
N
P
L
G
T
P
S
G
L
I
E
I
F
S
R
K
I
D
Q
F
G
Y
D
D
C
K
G
H
P
T
W
M
E
K
T
E
R
S
H
G
--------
G
P
G
S
D
K
H
P
I
W
L
Q
S
C
H
P
-
D
K
R
L
H
S
Q
M
C-
E
-
S
-
R
-
E
Y
R
E
T
Y
A
V
N
G
R
E
P
V
Y
I
S
P
V
D
A
K
A
R
G
I
K
D
G
D
I
V
R
V
F
N
D
R
G
Q
L
--
L
A
G
A
V
V
S
D
N
F
P
K
G
I
V
R
I
H
E
G
A
W
Y
G
P
V
G
K
D
G
S
-------
T
--
E
GGAEV
G
A
L
C
S
Y
G
D
-
P
N
T
L
T
L
D
I
-
G
T
S
K
L
A
Q
A
C
S
A
----------------
Y
T
-
C
L
V
E
F
E
K
Y
Q
G
K
V
P
K
V
S
S
F
D
G
P
I
E
V
E
I
--
48
HHSearch
74.81
21%
-54
- C7 -
1Q16
5
NARG_ECOLI
A:
[5-1241]
--
L
D
R
F
R
Y
F
K
Q
K
G
E
T
F
A
D
G
H
G
Q
L
L
NTNRDWED
G
Y
R
Q
R
W
Q
H
D
---
K
I
V
R
S
T
H
G
VNCT
G
----
S
C
S
W
K
I
Y
V
K
-
N
G
L
V
T
W
E
T
Q
Q
TDYPRT
R
P
D
L
P
-
N
H
E
-
P
R
G
C
P
R
G
A
S
Y
S
W
Y
L
Y
S
A
N
R
L
K
Y
P
M
M
R
K
R
L
M
-
K
M
W
R
E
A
K
A
L
H
SD
P
V
E
A
W
A
S
I
I
E
D
A
D
K
A
K
S
-
F
K
Q
A
R
G
R
G
G
F
V
R
S
S
W
Q
E
V
N
E
L
I
A
A
S
N
V
Y
T
I
K
N
Y
G
P
----
D
---
R
V
A
G
--
F
S
P
I
---
P
A
M
S
M
V
S
Y
A
S
G
A
R
Y
L
-
S
-
L
I
G
---
G
T
C
L
-
S
F
Y
-
D
W
Y
C
D
L
P
P
--
A
S
P
Q
T
W
G
E
Q
T
----
D
--
V
P
E
S
A
D
W
Y
N
S
S
Y
I
I
A
W
G
S
N
V
P
Q
T
R
T
P
D
A
--------
H
F
F
---
T
----
E
V
R
--
Y
K
G
T
K
T
V
A
V
T
P
D
Y
A
E
I
A
K
L
-
C
D
L
W
L
A
P
K
Q
G
T
D
A
A
M
A
L
A
M
G
H
V
M
L
R
E
FHLDNP
S
Q
Y
F
T
D
Y
V
R
R
Y
T
D
M
P
---------
M
L
V
M
L
E
E
R
DGYYAAGRMLRAADLVDALGQENNPEW
K
T
V
A
F
N
TNG
E
M
V
A
P
N
GS
I
G
F
R
W
GEKGKWNLEQRDGKTG
E
E
T
E
L
Q
L
S
LLGSQD
E
I
A
E
V
G
F
P
Y
FGGDGTEH
F
N
K
V
E
L
E
N
V
L
L
H
K
L
P
V
K
R
L
Q
L
ADG
S
T
A
L
V
T
T
V
Y
D
L
T
L
A
N
Y
G
L
ERGLNDVNCAT
S
Y
D
D
V
K
A
Y
T
P
A
W
A
E
Q
I
T
G
V
S
R
S
Q
I
I
R
I
A
R
E
F
A
D
-
N
A
D
K
T
HG
R
S
M
I
I
V
G
A
G
-
L
N
H
W
Y
H
L
D
M
N
Y
R
G
L
I
N
M
L
I
F
C
G
C
V
G
Q
S
G
G
G
W
A
H
Y
V
G
Q
E
K
L
R
P
-----
Q
-
T
-
G
W
-
Q
P
L
A
F
A
L
D
-
W
Q
R-----------
P
--
A
R
H
M
N
S
T
S
Y
F
Y
N
HS
S
Q
W
----
R
YETVTAEELL
S
P
M
---
A
DKSR
Y
T
G
H
L
I
D
F
N
V
R
A
E
R
M
G
--
W
L
--
P
S
A
PQLGTNPL
T
I
A
G
--
E
----
A
-
E
K
A
G
---
M
N
P
V
D
Y
T
V
K
---
S
L
K
E
GSIRFAAEQPE
N
G
K
N
H
P
R
N
L
F
I
W
R
S
N
L
L
G
S
S
G
K
G
H
E
F
M
L
K
Y
LLGTEHGIQGKDLGQQGGVKPEE
V
D
W
Q
DNGL
E
G
K
L
-
D
L
V
V
T
L
D
F
R
L
S
S
-
T
C
L
Y
S
D
I
I
L
P
T
A
T
W
Y
E
K
D
D
M
N
T
S
D
--
M
H
P
F
I
H
P
L
S
A
A
V
D
P
A
W
E
A
K
S
D
W
E
I
Y
K
A
I
A
K
K
F
S
E
V
C
-
V
G
H
L
G
K
E
T
D
I
V
T
L
P
IQ
H
D
S
AAELAQP
L
D
V
K
D
W
K
K
G
E
CDLIPGKTA
P
H
I
M
V
V
E
R
DYPA
T
Y
E
------
R
F
----
T
S
I
G
-
P
L
M
E
K
I
GNGGKG
I
A
W
N
T
Q
S
E
M
D
L
L
R
K
L
NYTKAEGPAKGQPMLNT
A
I
D
A
A
E
M
I
L
T
L
APETN
G
Q
V
A
V
K
A
W
A
A
L
S
E
F
T
G
RDHTHLALNKED
E
K
I
R
F
R
D
I
Q
A
Q
P
R
K
I
I
SSP
T
W
S
G
L
E
D
-----
E
H
V
S
Y
N
A
G-
Y
T
N
V
--
H
E
L
I
P
W
R
T
L
S
G
R
Q
Q
L
Y
Q
D
H
Q
W
M
R
D
--
F
G
E
S
L
L
V
Y
R
P
P
I
D
T
R
-
S
VKEVIGQK
S
N
G
N
Q
E
K
A
L
N
F
L
T
P
H
Q
-
K
W
G
I
H
S
T
Y
--
S
-
D
N
L
L
M
L
T
---
L
G
R
G
G
P
V
V
W
L
S
E
A
D
A
K
D
L
G
I
A
D
N
D
W
I
E
V
F
N
S
N
G
A
L
--
T
A
R
A
V
V
S
Q
R
V
P
A
G
M
T
M
M
Y
H
A
Q
E
R
I
V
--
N
L
P
G
-------
S
--
E
-----
I
T
Q
Q
R
G
G
I
-
H
N
S
V
T
R
I
T
--
P
K
P
T
H
M
I
G
G
Y
AHLAYGFNYYGTVGSN
R
D
-
E
F
V
V
V
R
K
M
K
N
I
D
W
L
D
G
E
G
N
D
Q
V
Q
E
S
---
44
HHSearch
72.72
20%
-50
- C9 -
2VPZ
4
?
A:
[30-747]
---------------------------------
A
P
W
Y
A
Q
E
V
---
K
S
V
Y
Q
I
-
C
----
E
GCFW
R
C
G
I
V
A
H
A
V
-
G
N
R
V
Y
K
V
E
G
-------
Y
E
A
N
P
-
K
S
R
-
G
R
L
C
P
R
G
Q
G
A
P
Q
T
T
Y
D
P
D
R
L
K
R
P
L
I
R
V
E
----------------------------------
G
S
Q
R
G
E
G
K
Y
R
V
A
T
W
E
E
A
L
D
H
I
A
K
K
M
L
E
I
R
E
K
Y
G
P
----
E
---
A
I
A
F
--
F
G
H
----
G
T
--
G
-
D
Y
W
F
-
V
D
F
L
P
A
-
A
W
G
---
S
P
-
N
A
A
K
P
S
V
S
L
C
T
------
A
P
R
E
V
A
S
Q
W
V
F
G
R
P
IG
G
H
E
P
I
D
W
E
N
A
R
Y
I
V
L
I
G
H
H
I
G
E
D
T
H
N
T
Q
-------
L
Q
D
F
---
A
----
L
A
L
--
K
N
G
A
K
V
V
V
V
D
P
R
F
S
T
A
A
A
K
-
A
H
R
W
L
P
I
K
P
G
T
D
T
A
L
L
L
A
W
I
H
V
L
I
Y
E
------
D
L
Y
D
K
E
Y
V
A
K
Y
T
V
G
F
---------
E
E
L
K
A
------------------------------------------------------------------------------------------------------------------------------------------
H
V
K
-----------------
D
F
T
P
E
W
A
E
K
H
T
E
I
P
A
Q
V
I
R
E
V
A
R
E
M
A
A
-
H
K-----
P
R
A
V
L
P
P
T
R
H
N
V
W
Y
G
D
D
T
Y
R
V
M
A
L
L
Y
V
N
V
L
L
G
N
Y
G
R
P
G
G
F
Y
I
A
Q
S
P
Y
L
E
K
Y
P
LPPLP
L
-
E
P
A
A
G
G
-----
C
S
-
G
P
------------
S
--
G
--------
G
----
D
H
E
----
P
----------
E
G
F
---
K
-------------------
P
--
R
A
--
D
K
G
--------
K
F
F
A
-----------
R
S
---
T
A
I
-
Q
E
L
I
E
---
P
M
I
T-----------
G
E
P
Y
P
I
K
G
L
F
A
Y
G
I
N
L
F
H
S
I
P
N
V
P
R
-
T
K
E
A
-------------------------------
L
K
N
L
-
D
L
Y
V
A
I
D
V
L
P
Q
E
-
H
V
M
W
A
D
V
I
L
P
E
A
T
Y
L
E
R
Y
D
D
F
V
L
V
A
H
K
T
P
F
I
Q
L
R
T
P
A
H
E
P
L
F
D
T
K
P
G
W
W
I
A
R
E
L
G
L
R
L
G
L
---
E
Q
Y
F
P
-----------
W
---------
K
T
I
E
E
Y
L
E
T
R
----------------------
L
Q
------
S
-----------------------
L
--------------------------------------------------
G
L
D
L
E
T
M
K
G
M
-
G
-------------
T
L
V
Q
R
-------------
G
-
K
---------
P
W
L
--
E
D
--
W
E
K
---
E
G
R
L
P
F
G
T
A
S
G
K
I
E
L
Y
C
Q
R
F
K
E
A
---
G
H
Q
P
L
P
V
F
T
P
P
E
E
---------------
P
P
E
G
F
Y
R
L
L
Y
G
R
S
-
P
V
H
T
F
A
R
T
--
Q
-
N
N
W
-
V
L
M
E
---
M
D
P
E
N
E
V
W
I
H
K
E
E
A
K
R
L
G
L
K
E
G
D
Y
V
M
L
V
N
Q
D
G
V
K
E
G
P
V
R
V
K
P
T
A
R
I
R
K
D
C
V
Y
I
V
H
G
F
G
H
K
A
--
P
L
M
-----------
R
-----
L
A
H
G
R
G
A
S
-
D
N
Y
L
Q
T
R
Y
-
K
L
D
P
I
S
G
G
A
G
L
----------------
R
V
-
N
F
V
R
L
E
K
A
E
R
P
R
L
P
S
L
T
G
L
A
K
R
P
F
D
E
R
R
51
HHSearch
72.36
18%
-55
- C7 -
2NAP
5
NAPA_DESDA
A:
[4-723]
--------------------------------------
R
P
E
---
K
W
V
K
G
V
-
C
----
R
YCGT
G
C
G
V
L
V
G
V
K
-
D
G
K
A
V
A
I
Q
G
-------
N
P
N
N
H
-
N
A
G
-
L
-
L
C
L
K
G
S
L
L
I
P
V
L
N
S
K
E
R
V
T
Q
P
L
V
R
R
H
--------------------------------------
K
G
G
K
L
E
P
V
S
W
D
E
A
L
D
L
M
A
S
R
F
R
S
S
I
D
M
Y
G
P
----
N
---
S
V
A
W
--
Y
G
S
G
---
Q
C
L
T
E
E
S
Y
V
A
-
N
K
I
F
-
K
G
G
F
G
---
T
N
-
N
V
D
G
N
-
P
R
L
C
M
A
S
A
V
G
G
Y
V
T
S
F
G
K
D
E
----
P
--
M
G
T
Y
A
D
I
D
Q
A
T
C
F
F
I
I
G
S
N
T
S
E
A
H
P
V
L
F
--------
R
R
I
---
A
----
R
R
K
Q
V
E
P
G
V
K
I
I
V
A
D
P
R
R
T
N
T
S
R
I
A
-
D
M
H
V
A
F
R
P
G
T
D
L
A
F
M
H
S
M
A
W
V
I
I
N
E
------
E
L
D
N
P
R
F
W
Q
R
Y
V
N
F
M
D
AEGKPSD
F
E
G
Y
K
A
------------------------------------------------------------------------------------------------------------------------------------------
F
L
E
-----------------
N
Y
R
P
E
K
V
A
E
I
C
R
V
P
V
E
Q
I
Y
G
A
A
R
A
F
A
E
S
A
------
A
T
M
S
L
W
C
M
G
-
I
N
Q
R
V
Q
G
V
F
A
N
N
L
I
H
N
L
H
L
I
T
G
Q
I
C
R
P
G
A
T
S
F
S
L
T
G
Q
P
N
A
C
G
-----
G
V
R
-
D
G
-
G
A----
L
S
H
L
L
------------
P
--
A
--------
G
----
R
A
I
----
P
----------
N
A
K
-----------------------
H
--
R
A
--
E
M
E
--------
K
L
W
G
--
L
PEGR
I
A
P
E
P
G
---
Y
H
T
-
V
A
L
F
E
---
A
--------------
L
G
R
G
D
V
K
C
M
I
I
C
E
T
N
P
A
H
T
L
P
N
L
N
K
-
V
H
K
A
-------------------------------
M
S
H
P
E
S
F
I
V
C
I
E
A
F
P
D
A
V
T
L
E
Y
A
D
L
V
L
P
P
A
F
W
C
E
R
D
G
V
Y
G
C
---
G
E
R
R
Y
S
L
T
E
K
A
V
D
P
P
G
Q
C
R
P
T
V
N
T
L
V
E
F
A
R
R
A
G
V
D
P
Q
L
V
N
F
R
-----------
N
----------
A
E
D
V
W
N
E
-
W
----------------------
R
M
------
V
S
KGTT
Y
--
D
-
F
------------
W
--------------------------------------------------
G
M
T
R
E
R
L
R
K
E
-
S
-------------
G
L
I
W
P
-------------
C
P
S
E
-
D
H
PGTSL
R
Y
V
R
G
Q
D
PC
V
P
A
D
HP
D
R
F
F
F
Y
G
K
P
D
G
R
A
V
I
W
M
R
P
A
K
G
--------------
A
A
-------------
E
E
P
D
A
E
Y
P
L
Y
L
T
S
M
R
V
-
I
D
H
W
H
T
A
T
MT
G
K
V
-
P
-
E
L
Q
K
---
A
N
P
I
A
F
V
E
I
N
E
E
D
A
A
R
T
G
I
K
H
G
D
S
V
I
V
E
T
R
R
D
A
M
--
E
L
P
A
R
V
S
D
V
C
R
P
G
L
I
A
V
P
F
F
D
P
------------------------------
K
K
L
-
V
N
K
L
F
L
D
--
A
T
D
P
V
S
R
E
P
E
Y
----------------
K
I
-
C
A
A
R
V
R
K
A
--------------------
46
HHSearch
70.77
20%
-57
* C7 *
2E7Z
8
AHY_PELAE
A:
[5-727]
---------------------------------------------
V
C
Q
S
C
-
D
----
I
----
N
C
V
V
E
A
E
V
K
A
D
G
K
I
Q
T
K
S
I
-------
S
E
P
H
P
T
T
P
P
N
S
-
I
C
M
K
S
V
N
A
D
T
I
R
T
H
K
D
R
V
L
Y
P
L
K
N
V
G
-----------------------------------
S
K
R
G
E
Q
R
W
E
R
I
S
W
D
Q
A
L
D
E
I
A
E
K
L
K
K
I
I
A
K
Y
G
P
----
E
---
S
L
G
V
--
S
Q
T
E
---
I
N
Q
Q
S
E
Y
G
T
L
-
R
R
F
M
-
N
-
L
L
G
---
S
P
-
N
W
T
S
A
-
M
Y
M
C
I
------
G
N
T
A
G
V
H
R
V
T
H
G
S
----
Y
S
F
A
S
F
A
D
S
N
C
L
L
F
I
G
K
N
L
S
N
H
N
W
V
S
Q
-------
F
N
D
L
---
K
----
A
A
L
--
K
R
G
C
K
L
I
V
L
D
P
R
R
T
K
V
A
E
M
A
-
D
I
W
L
P
L
R
Y
G
T
D
A
A
L
F
L
G
M
I
N
V
I
I
N
E
------
Q
L
Y
D
K
E
F
V
E
N
W
C
V
G
F
---------
E
E
L
K
E
------------------------------------------------------------------------------------------------------------------------------------------
R
V
Q
-----------------
E
Y
P
L
D
K
V
A
E
I
T
G
C
D
A
G
E
I
R
K
A
A
V
M
F
A
T
E
S
------
P
A
S
I
P
W
A
V
S
-
T
D
M
Q
K
N
S
C
S
A
I
R
A
Q
C
I
L
R
A
I
V
G
S
F
V
N
-
G
A
E
I
L
G
A
P
H
S
D
L
V
-
P
-----
I
-
S
-
K
I
-
Q
MHEA-
L
P
E
E
K
------------
K
K
L
Q
--------
L
----
G
T
E
----
T
----------
Y
P
F
LTY
T
-------------------
G
MS
A
L
E
E
P
S
E
--------
R
V
Y
G
VK
Y
----
F
-
H
N
M
G
AFM
A
N
P
-
T
A
L
F
T
A
M
A
T
--------------
E
K
P
Y
P
V
K
A
F
F
A
L
A
S
N
A
L
M
G
Y
A
N
Q
Q
N
-
A
L
K
G
-------------------------------
L
M
N
Q
-
D
L
V
V
C
Y
D
Q
F
M
T
P
-
T
A
Q
L
A
D
Y
V
L
P
G
D
H
W
L
E
R
P
V
V
Q
P
N
W
-
E
G
I
P
F
G
N
T
S
Q
Q
V
V
E
P
A
G
E
A
K
D
E
Y
Y
F
I
R
E
L
A
V
R
M
G
L
---
E
E
H
F
P
-----------
W
-
K
--------
D
R
L
E
L
I
N
Y
R
----------------------
I
S
-----------------
P
------------
T
--------------------------------------------------
G
M
E
W
E
E
Y
Q
K
Q
-
Y
-------------
T
Y
M
S
K
-------------
L
P
----------
D
Y
---------
F
G
--
P
E
G
V
G
V
A
T
P
S
G
K
V
E
L
Y
S
S
V
F
E
K
L
---
G
Y
D
P
L
P
Y
Y
H
E
P
L
Q
T
E
-
I
SD------
P
E
L
A
K
E
Y
P
L
I
L
F
A
G
L
R
E
D
S
N
F
Q
S
C
Y
--
H
-
Q
P
G
-
I
L
R
D
---
A
E
P
D
P
V
A
L
L
H
P
K
T
A
Q
S
L
G
L
P
S
G
E
W
I
W
V
E
T
T
H
G
R
L
--
K
L
L
L
K
H
D
G
A
Q
P
E
G
T
I
R
I
P
H
G
R
W
C
P
E
--
Q
E
G
G
-------
P
ET
G
-----
F
S
G
A
M
L
H
N
D
A
M
V
L
S
D
D
D
W
N
L
D
P
E
Q
G
L
P
N
L
----------------
R
G
G
I
L
A
K
A
Y
K
C
--------------------