@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_0980: (2015-12-19 )
MIELDINASDKSLSHRAVIFSLLAQKPCFVRNFLMGEDCLSSLEIAQNLGAKVENTAKNSFKITPPTTIKEPNKILNCNNSGTSMRLYSGLLSAQKGLFVLSGDNSLNARPMKRIIEPLKAFGAKILGREDNHFAPLAIVGGPLKACDYESPIASAQVKSAFILSALQAQGISAYKESELSRNHTEIMLKSLGANIQNQDGVLKISPLEKPLESFDFTIANDPSSAFFLALACAITPKSRLLLKNVLLNPTRIEAFEVLKKMGAHIEYVIQSKDLEVIGDIYIEHAPLKAISIDQNIASLIDEIPALSIAMLFAKGKSMVRNAKDLRAKESDRIKAVVSNFKALGIECEEFEDGFYIEGLGDASQLKQHFSKIKPPIIKSFNDHRIAMSFAVLTLALPLEIDNLECANISFPTFQLWLNLFKKRSLNGN
Atome Classification :
(26 SA)
.........10........20........30........40........50.......-.-60..--..---.---.--..70........80........90........100.......110.......120.......130.......140-.-...-...150.......160.......170.......180.......190.....---..200----........210.........220.......230.......-240.......250.......260.......-270-.--......280.......290..-..-..-.300........310.......320.......330.......340.......350.......360.......370.......380.......390.-....--..400.......410..-----.....420.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
I
E
L
D
INASDKSL
S
H
R
A
V
I
F
S
L
L
AQK
P
C
F
V
R
N
F
LM
G
E
D
C
L
S
S
L
E
I
A
Q
N
LGA
K
V
ENTAK-N-
S
F
KI--TP---P---T--TIKEPN
K
I
L
NCNNSGT
S
M
R
L
Y
S
G
L
L
S
AQK
G
L
F
V
L
SGDNSL
N
A
R
P
M
K
R
I
I
E
P
L
K
A
F
G
A
K
I
LGREDNHFA
P
L
A
I
VGG-P-LKA-CDYESPI
A
S
A
Q
V
K
S
A
F
I
L
S
A
L
Q
A
QGI
S
A
Y
K
E
S
E
LSR
N
H
T
E
I
M
L
K
S
LGANIQ---NQDG-----
V
L
K
IS
P
L
EK--
P
L
E
SF
D
F
T
IANDPS
S
A
F
F
L
A
L
A
C
AITP
K
S
-
R
L
L
L
K
N
VLLN
P
T
R
I
E
A
F
E
V
L
K
K
MGA
H
I
E
Y
V
-
I
QS-K--D
L
E
V
I
G
D
I
Y
IEHAP
L
K
A
I
SI
D
-
Q
N
-
I
A
-
S
L
-
I
D
EI
P
A
L
S
I
A
M
L
F
AK
G
K
S
M
V
R
N
A
K
D
LRAK
E
S
D
R
I
K
A
V
V
SN
F
K
A
LGI
E
C
E
EFED
G
F
Y
I
EGLG
D
A
S
Q
L
K
Q
H
F
S
KIK
P
P
I
I
KSFND
H
R
I
A
M
S
F
A
V
L
-
T
L
A
L
--
P
L
E
IDN
L
E
CANIS
F
P
T
F
-----
Q
L
W
L
N
L
F
K
KRSLNGN
27
PsiBlast_CBE
95.04
39%
-94
- C8 -
4EGR
3
AROA_COXBU
C:
[22-439]
--------
G
D
K
S
I
S
H
R
A
V
L
L
A
A
I
A
E
G
Q
T
Q
V
D
G
F
L
M
G
A
D
N
L
A
M
V
S
A
L
Q
Q
M
G
A
S
I
Q
V
I
E
D
-
E
-
N
I
L
V
--
V
E
---
G
VGM
T
--
G
L
Q
A
P
P
E
A
L
D
C
G
N
S
G
T
A
I
R
L
L
S
G
L
L
A
G
Q
P
F
N
T
V
L
T
G
D
S
S
L
Q
R
R
P
M
K
R
I
I
D
P
L
T
L
M
G
A
K
I
--
D
S
T
G
N
V
P
P
L
K
I
Y
G
N
-
P
R
L
T
G
-
I
H
Y
Q
L
P
M
A
S
A
Q
V
K
S
C
L
L
L
A
G
L
Y
A
R
G
K
T
C
I
T
E
P
A
P
S
R
D
H
T
E
R
L
L
K
H
F
H
Y
T
L
Q
-----
K
Q
-----
S
I
C
V
S
G
G
G
K
---
L
K
A
N
D
I
S
I
P
G
D
I
S
S
A
A
F
F
I
V
A
A
T
I
T
P
G
S
-
A
I
R
L
C
R
V
G
V
N
P
T
R
L
G
V
I
N
L
L
K
M
M
G
A
D
I
E
V
T
H
Y
T
E
-
K
----
E
P
T
A
D
I
T
V
R
H
A
R
L
K
G
I
D
I
P
-
P
D
-
Q
V
-
P
L
T
I
D
E
F
P
V
L
L
I
A
A
A
V
A
Q
G
K
T
V
L
R
D
A
A
E
L
R
V
K
E
T
D
R
I
A
A
M
V
D
G
L
Q
K
L
G
I
A
A
E
S
L
P
D
G
V
I
I
Q
G
-----------
G
T
L
E
G
G
E
V
N
S
Y
D
D
H
R
I
A
M
A
F
A
V
A
G
T
L
A
K
G-
P
V
R
I
R
N
C
D
N
V
K
T
S
F
P
N
F
VELAN
E
V
G
M
N
V
K
G
V
R
G
R
G
--
32
PsiBlast_CBE
94.88
39%
-105
- C8 -
3ROI
9
AROA_COXBU
B:
[22-436]
--------
G
D
K
S
I
S
H
R
A
V
L
L
A
A
I
A
E
G
Q
T
Q
V
D
G
F
L
M
G
A
D
N
L
A
M
V
S
A
L
Q
Q
M
G
A
S
I
Q
V
I
E
D
-
E
-
N
I
L
V
--
V
E
---
G
VGM
T
--
G
L
Q
A
P
P
E
A
L
D
C
G
N
S
G
T
A
I
R
L
L
S
G
L
L
A
G
Q
P
F
N
T
V
L
T
G
D
S
S
L
Q
R
R
P
M
K
R
I
I
D
P
L
T
L
M
G
A
K
I
--
D
S
T
G
N
V
P
P
L
K
I
Y
G
N
-
P
R
L
T
G
-
I
H
Y
Q
L
P
M
A
S
A
Q
V
K
S
C
L
L
L
A
G
L
Y
A
R
G
K
T
C
I
T
E
P
A
P
S
R
D
H
T
E
R
L
L
K
H
F
H
Y
T
L
Q
---
K
D
K
Q
-----
S
I
C
V
S
G
G
G
K
---
L
K
A
N
D
I
S
I
P
G
D
I
S
S
A
A
F
F
I
V
A
A
T
I
T
P
G
S
-
A
I
R
L
C
R
V
G
V
N
P
T
R
L
G
V
I
N
L
L
K
M
M
G
A
D
I
E
V
T
H
Y
T
E
-
K
---
E
E
P
T
A
D
I
T
V
R
H
A
R
L
K
G
I
D
I
P
-
P
D
-
Q
V
-
P
L
T
I
D
E
F
P
V
L
L
I
A
A
A
V
A
Q
G
K
T
V
L
R
D
A
A
E
L
R
V
K
E
T
D
R
I
A
A
M
V
D
G
L
Q
K
L
G
I
A
A
E
S
L
P
D
G
V
I
I
Q
G
-----------
G
T
L
E
G
G
E
V
N
S
Y
D
D
H
R
I
A
M
A
F
A
V
A
G
T
L
A
K
G
-
P
V
R
I
R
N
C
D
N
V
K
T
S
F
P
N
F
V
E
L
A
N
E
V
G
M
N
V
K
G
V
R
-----
28
PsiBlast_CBE
94.86
39%
-95
- C8 -
4EGR
3
AROA_COXBU
B:
[22-439]
--------
G
D
K
S
I
S
H
R
A
V
L
L
A
A
I
A
E
G
Q
T
Q
V
D
G
F
L
M
G
A
D
N
L
A
M
V
S
A
L
Q
Q
M
G
A
S
I
Q
V
I
E
D
-
E
-
N
I
L
V
--
V
E
---
G
VGM
T
--
G
L
Q
A
P
P
E
A
L
D
C
G
N
S
G
T
A
I
R
L
L
S
G
L
L
A
G
Q
P
F
N
T
V
L
T
G
D
S
S
L
Q
R
R
P
M
K
R
I
I
D
P
L
T
L
M
G
A
K
I
--
D
S
T
G
N
V
P
P
L
K
I
Y
G
N
-
P
R
L
T
G
-
I
H
Y
Q
L
P
M
A
S
A
Q
V
K
S
C
L
L
L
A
G
L
Y
A
R
G
K
T
C
I
T
E
P
A
P
S
R
D
H
T
E
R
L
L
K
H
F
H
Y
T
L
Q
-----
K
Q
-----
S
I
C
V
S
G
G
G
K
---
L
K
A
N
D
I
S
I
P
G
D
I
S
S
A
A
F
F
I
V
A
A
T
I
T
P
G
S
-
A
I
R
L
C
R
V
G
V
N
P
T
R
L
G
V
I
N
L
L
K
M
M
G
A
D
I
E
V
T
H
Y
T
E
-
K
----
E
P
T
A
D
I
T
V
R
H
A
R
L
K
G
I
D
I
P
-
P
D
-
Q
V
-
P
L
T
I
D
E
F
P
V
L
L
I
A
A
A
V
A
Q
G
K
T
V
L
R
D
A
A
E
L
R
V
K
E
T
D
R
I
A
A
M
V
D
G
L
Q
K
L
G
I
A
A
E
S
L
P
D
G
V
I
I
Q
G
-----------
G
T
L
E
G
G
E
V
N
S
Y
D
D
H
R
I
A
M
A
F
A
V
A
G
T
L
A
K
G-
P
V
R
I
R
N
C
D
N
V
K
T
S
F
P
N
F
VELAN
E
V
G
M
N
V
K
G
V
R
G
R
G
--
25
PsiBlast_CBE
94.49
39%
-95
- C8 -
4EGR
3
AROA_COXBU
E:
[22-439]
--------
G
D
K
S
I
S
H
R
A
V
L
L
A
A
I
A
E
G
Q
T
Q
V
D
G
F
L
M
G
A
D
N
L
A
M
V
S
A
L
Q
Q
M
G
A
S
I
Q
V
I
E
D
-
E
-
N
I
L
V
--
V
E
---
G
VGM
T
--
G
L
Q
A
P
P
E
A
L
D
C
G
N
S
G
T
A
I
R
L
L
S
G
L
L
A
G
Q
P
F
N
T
V
L
T
G
D
S
S
L
Q
R
R
P
M
K
R
I
I
D
P
L
T
L
M
G
A
K
I
--
D
S
T
G
N
V
P
P
L
K
I
Y
G
N
-
P
R
L
T
G
-
I
H
Y
Q
L
P
M
A
S
A
Q
V
K
S
C
L
L
L
A
G
L
Y
A
R
G
K
T
C
I
T
E
P
A
P
S
R
D
H
T
E
R
L
L
K
H
F
H
Y
T
L
Q
-----
K
Q
-----
S
I
C
V
S
G
G
G
K
---
L
K
A
N
D
I
S
I
P
G
D
I
S
S
A
A
F
F
I
V
A
A
T
I
T
P
G
S
-
A
I
R
L
C
R
V
G
V
N
P
T
R
L
G
V
I
N
L
L
K
M
M
G
A
D
I
E
V
T
H
Y
T
E
-
K
----
E
P
T
A
D
I
T
V
R
H
A
R
L
K
G
I
D
I
P
-
P
D
-
Q
V
-
P
L
T
I
D
E
F
P
V
L
L
I
A
A
A
V
A
Q
G
K
T
V
L
R
D
A
A
E
L
R
V
K
E
T
D
R
I
A
A
M
V
D
G
L
Q
K
L
G
I
A
A
E
S
L
P
D
G
V
I
I
Q
G
-----------
G
T
L
E
G
G
E
V
N
S
Y
D
D
H
R
I
A
M
A
F
A
V
A
G
T
L
A
K
G-
P
V
R
I
R
N
C
D
N
V
K
T
S
F
P
N
F
VELAN
E
V
G
M
N
V
K
G
V
R
G
R
G
--
5
PsiBlast_PDB
94.15
39%
-91
- C8 -
4ZND
5
AROA_COXBU
A:
[22-438]
--------
G
D
K
S
I
S
H
R
A
V
L
L
A
A
I
A
E
G
Q
T
Q
V
D
G
F
L
M
G
A
D
N
L
A
M
V
S
A
L
Q
Q
M
G
A
S
I
Q
V
I
E
D
-
E
-
N
I
L
V
--
V
E
---
G
VGM
T
--
G
L
Q
A
P
P
E
A
L
D
C
G
N
S
G
T
A
I
R
L
L
S
G
L
L
A
G
Q
P
F
N
T
V
L
T
G
D
S
S
L
Q
R
R
P
M
K
R
I
I
D
P
L
T
L
M
G
A
K
I
--
D
S
T
G
N
V
P
P
L
K
I
Y
G
N
-
P
R
L
T
G
-
I
H
Y
Q
L
P
M
A
S
A
Q
V
K
S
C
L
L
L
A
G
L
Y
A
R
G
K
T
C
I
T
E
P
A
P
S
R
D
H
T
E
R
L
L
K
H
F
H
Y
T
L
Q
---
K
D
K
Q
-----
S
I
C
V
S
G
G
G
K
---
L
K
A
N
D
I
S
I
P
G
D
I
S
S
A
A
F
F
I
V
A
A
T
I
T
P
G
S
-
A
I
R
L
C
R
V
G
V
N
P
T
R
L
G
V
I
N
L
L
K
M
M
G
A
D
I
E
V
T
H
Y
T
E
-
K
--
N
E
E
P
T
A
D
I
T
V
R
H
A
R
L
K
G
I
D
I
P
-
P
D
-
Q
V
-
P
L
T
I
D
E
F
P
V
L
L
I
A
A
A
V
A
Q
G
K
T
V
L
R
D
A
A
E
L
R
V
K
E
T
D
R
I
A
A
M
V
D
G
L
Q
K
L
G
I
A
A
E
S
L
P
D
G
V
I
I
Q
G
-----------
G
T
L
E
G
G
E
V
N
S
Y
D
D
H
R
I
A
M
A
F
A
V
A
G
T
L
A
K
G
-
P
V
R
I
R
N
C
D
N
V
K
T
S
F
P
N
F
V
E
L
A
N
E
V
G
M
N
V
K
G
V
R
G
R
---
31
PsiBlast_CBE
94.05
39%
-89
- C8 -
3SLH
6
AROA_COXBU
B:
[22-440]
--------
G
D
K
S
I
S
H
R
A
V
L
L
A
A
I
A
E
G
Q
T
Q
V
D
G
F
L
M
G
A
D
N
L
A
M
V
S
A
L
Q
Q
M
G
A
S
I
Q
V
I
E
D
-
E
-
N
I
L
V
--
V
E
---
G
VGM
T
--
G
L
Q
A
P
P
E
A
L
D
C
G
N
S
G
T
A
I
R
L
L
S
G
L
L
A
G
Q
P
F
N
T
V
L
T
G
D
S
S
L
Q
R
R
P
M
K
R
I
I
D
P
L
T
L
M
G
A
K
I
--
D
S
T
G
N
V
P
P
L
K
I
Y
G
N
-
P
R
L
T
G
-
I
H
Y
Q
L
P
M
A
S
A
Q
V
K
S
C
L
L
L
A
G
L
Y
A
R
G
K
T
C
I
T
E
P
A
P
S
R
D
H
T
E
R
L
L
K
H
F
H
Y
T
L
Q
---
K
D
K
Q
-----
S
I
C
V
S
G
G
G
K
---
L
K
A
N
D
I
S
I
P
G
D
I
S
S
A
A
F
F
I
V
A
A
T
I
T
P
G
S
-
A
I
R
L
C
R
V
G
V
N
P
T
R
L
G
V
I
N
L
L
K
M
M
G
A
D
I
E
V
T
H
Y
T
E
-
K
--
N
E
E
P
T
A
D
I
T
V
R
H
A
R
L
K
G
I
D
I
P
-
P
D
-
Q
V
-
P
L
T
I
D
E
F
P
V
L
L
I
A
A
A
V
A
Q
G
K
T
V
L
R
D
A
A
E
L
R
V
K
E
T
D
R
I
A
A
M
V
D
G
L
Q
K
L
G
I
A
A
E
S
L
P
D
G
V
I
I
Q
G
-----------
G
T
L
E
G
G
E
V
N
S
Y
D
D
H
R
I
A
M
A
F
A
V
A
G
T
L
A
K
G
-
P
V
R
I
R
N
C
D
N
V
K
T
S
F
P
N
F
V
E
L
A
N
E
V
G
M
N
V
K
G
V
R
G
R
G
G
F
26
PsiBlast_CBE
93.97
39%
-93
- C8 -
4EGR
3
AROA_COXBU
D:
[22-439]
--------
G
D
K
S
I
S
H
R
A
V
L
L
A
A
I
A
E
G
Q
T
Q
V
D
G
F
L
M
G
A
D
N
L
A
M
V
S
A
L
Q
Q
M
G
A
S
I
Q
V
I
E
D
-
E
-
N
I
L
V
--
V
E
---
G
VGM
T
--
G
L
Q
A
P
P
E
A
L
D
C
G
N
S
G
T
A
I
R
L
L
S
G
L
L
A
G
Q
P
F
N
T
V
L
T
G
D
S
S
L
Q
R
R
P
M
K
R
I
I
D
P
L
T
L
M
G
A
K
I
--
D
S
T
G
N
V
P
P
L
K
I
Y
G
N
-
P
R
L
T
G
-
I
H
Y
Q
L
P
M
A
S
A
Q
V
K
S
C
L
L
L
A
G
L
Y
A
R
G
K
T
C
I
T
E
P
A
P
S
R
D
H
T
E
R
L
L
K
H
F
H
Y
T
L
Q
-----
K
Q
-----
S
I
C
V
S
G
G
G
K
---
L
K
A
N
D
I
S
I
P
G
D
I
S
S
A
A
F
F
I
V
A
A
T
I
T
P
G
S
-
A
I
R
L
C
R
V
G
V
N
P
T
R
L
G
V
I
N
L
L
K
M
M
G
A
D
I
E
V
T
H
Y
T
E
-
K
----
E
P
T
A
D
I
T
V
R
H
A
R
L
K
G
I
D
I
P
-
P
D
-
Q
V
-
P
L
T
I
D
E
F
P
V
L
L
I
A
A
A
V
A
Q
G
K
T
V
L
R
D
A
A
E
L
R
V
K
E
T
D
R
I
A
A
M
V
D
G
L
Q
K
L
G
I
A
A
E
S
L
P
D
G
V
I
I
Q
G
-----------
G
T
L
E
G
G
E
V
N
S
Y
D
D
H
R
I
A
M
A
F
A
V
A
G
T
L
A
K
G-
P
V
R
I
R
N
C
D
N
V
K
T
S
F
P
N
F
VELAN
E
V
G
M
N
V
K
G
V
R
G
R
G
--
4
PsiBlast_PDB
93.79
39%
-93
- C8 -
4EGR
3
AROA_COXBU
A:
[22-439]
--------
G
D
K
S
I
S
H
R
A
V
L
L
A
A
I
A
E
G
Q
T
Q
V
D
G
F
L
M
G
A
D
N
L
A
M
V
S
A
L
Q
Q
M
G
A
S
I
Q
V
I
E
D
-
E
-
N
I
L
V
--
V
E
---
G
VGM
T
--
G
L
Q
A
P
P
E
A
L
D
C
G
N
S
G
T
A
I
R
L
L
S
G
L
L
A
G
Q
P
F
N
T
V
L
T
G
D
S
S
L
Q
R
R
P
M
K
R
I
I
D
P
L
T
L
M
G
A
K
I
--
D
S
T
G
N
V
P
P
L
K
I
Y
G
N
-
P
R
L
T
G
-
I
H
Y
Q
L
P
M
A
S
A
Q
V
K
S
C
L
L
L
A
G
L
Y
A
R
G
K
T
C
I
T
E
P
A
P
S
R
D
H
T
E
R
L
L
K
H
F
H
Y
T
L
Q
-----
K
Q
-----
S
I
C
V
S
G
G
G
K
---
L
K
A
N
D
I
S
I
P
G
D
I
S
S
A
A
F
F
I
V
A
A
T
I
T
P
G
S
-
A
I
R
L
C
R
V
G
V
N
P
T
R
L
G
V
I
N
L
L
K
M
M
G
A
D
I
E
V
T
H
Y
T
E
-
K
----
E
P
T
A
D
I
T
V
R
H
A
R
L
K
G
I
D
I
P
-
P
D
-
Q
V
-
P
L
T
I
D
E
F
P
V
L
L
I
A
A
A
V
A
Q
G
K
T
V
L
R
D
A
A
E
L
R
V
K
E
T
D
R
I
A
A
M
V
D
G
L
Q
K
L
G
I
A
A
E
S
L
P
D
G
V
I
I
Q
G
-----------
G
T
L
E
G
G
E
V
N
S
Y
D
D
H
R
I
A
M
A
F
A
V
A
G
T
L
A
K
G
-
P
V
R
I
R
N
C
D
N
V
K
T
S
F
P
N
F
V
E
L
A
N
E
V
G
M
N
V
K
G
V
R
G
R
G
--
24
PsiBlast_CBE
93.72
39%
-94
- C8 -
4EGR
3
AROA_COXBU
F:
[22-439]
--------
G
D
K
S
I
S
H
R
A
V
L
L
A
A
I
A
E
G
Q
T
Q
V
D
G
F
L
M
G
A
D
N
L
A
M
V
S
A
L
Q
Q
M
G
A
S
I
Q
V
I
E
D
-
E
-
N
I
L
V
--
V
E
---
G
VGM
T
--
G
L
Q
A
P
P
E
A
L
D
C
G
N
S
G
T
A
I
R
L
L
S
G
L
L
A
G
Q
P
F
N
T
V
L
T
G
D
S
S
L
Q
R
R
P
M
K
R
I
I
D
P
L
T
L
M
G
A
K
I
--
D
S
T
G
N
V
P
P
L
K
I
Y
G
N
-
P
R
L
T
G
-
I
H
Y
Q
L
P
M
A
S
A
Q
V
K
S
C
L
L
L
A
G
L
Y
A
R
G
K
T
C
I
T
E
P
A
P
S
R
D
H
T
E
R
L
L
K
H
F
H
Y
T
L
Q
-----
K
Q
-----
S
I
C
V
S
G
G
G
K
---
L
K
A
N
D
I
S
I
P
G
D
I
S
S
A
A
F
F
I
V
A
A
T
I
T
P
G
S
-
A
I
R
L
C
R
V
G
V
N
P
T
R
L
G
V
I
N
L
L
K
M
M
G
A
D
I
E
V
T
H
Y
T
E
-
K
----
E
P
T
A
D
I
T
V
R
H
A
R
L
K
G
I
D
I
P
-
P
D
-
Q
V
-
P
L
T
I
D
E
F
P
V
L
L
I
A
A
A
V
A
Q
G
K
T
V
L
R
D
A
A
E
L
R
V
K
E
T
D
R
I
A
A
M
V
D
G
L
Q
K
L
G
I
A
A
E
S
L
P
D
G
V
I
I
Q
G
-----------
G
T
L
E
G
G
E
V
N
S
Y
D
D
H
R
I
A
M
A
F
A
V
A
G
T
L
A
K
G-
P
V
R
I
R
N
C
D
N
V
K
T
S
F
P
N
F
VELAN
E
V
G
M
N
V
K
G
V
R
G
R
G
--
30
PsiBlast_CBE
93.70
39%
-92
- C8 -
3SLH
1
AROA_COXBU
C:
[22-439]
--------
G
D
K
S
I
S
H
R
A
V
L
L
A
A
I
A
E
G
Q
T
Q
V
D
G
F
L
M
G
A
D
N
L
A
M
V
S
A
L
Q
Q
M
G
A
S
I
Q
V
I
E
D
-
E
-
N
I
L
V
--
V
E
---
G
VGM
T
--
G
L
Q
A
P
P
E
A
L
D
C
G
N
S
G
T
A
I
R
L
L
S
G
L
L
A
G
Q
P
F
N
T
V
L
T
G
D
S
S
L
Q
R
R
P
M
K
R
I
I
D
P
L
T
L
M
G
A
K
I
--
D
S
T
G
N
V
P
P
L
K
I
Y
G
N
-
P
R
L
T
G
-
I
H
Y
Q
L
P
M
A
S
A
Q
V
K
S
C
L
L
L
A
G
L
Y
A
R
G
K
T
C
I
T
E
P
A
P
S
R
D
H
T
E
R
L
L
K
H
F
H
Y
T
L
Q
---
K
D
K
Q
-----
S
I
C
V
S
G
G
G
K
---
L
K
A
N
D
I
S
I
P
G
D
I
S
S
A
A
F
F
I
V
A
A
T
I
T
P
G
S
-
A
I
R
L
C
R
V
G
V
N
P
T
R
L
G
V
I
N
L
L
K
M
M
G
A
D
I
E
V
T
H
Y
T
E
-
K
--
N
E
E
P
T
A
D
I
T
V
R
H
A
R
L
K
G
I
D
I
P
-
P
D
-
Q
V
-
P
L
T
I
D
E
F
P
V
L
L
I
A
A
A
V
A
Q
G
K
T
V
L
R
D
A
A
E
L
R
V
K
E
T
D
R
I
A
A
M
V
D
G
L
Q
K
L
G
I
A
A
E
S
L
P
D
G
V
I
I
Q
G
-----------
G
T
L
E
G
G
E
V
N
S
Y
D
D
H
R
I
A
M
A
F
A
V
A
G
T
L
A
K
G-
P
V
R
I
R
N
C
D
N
V
K
T
S
F
P
N
F
VELAN
E
V
G
M
N
V
K
G
V
R
G
R
G
--
2
PsiBlast_PDB
93.29
39%
-107
- C8 -
3ROI
13
AROA_COXBU
A:
[22-438]
--------
G
D
K
S
I
S
H
R
A
V
L
L
A
A
I
A
E
G
Q
T
Q
V
D
G
F
L
M
G
A
D
N
L
A
M
V
S
A
L
Q
Q
M
G
A
S
I
Q
V
I
E
D
-
E
-
N
I
L
V
--
V
E
---
G
VGM
T
--
G
L
Q
A
P
P
E
A
L
D
C
G
N
S
G
T
A
I
R
L
L
S
G
L
L
A
G
Q
P
F
N
T
V
L
T
G
D
S
S
L
Q
R
R
P
M
K
R
I
I
D
P
L
T
L
M
G
A
K
I
--
D
S
T
G
N
V
P
P
L
K
I
Y
G
N
-
P
R
L
T
G
-
I
H
Y
Q
L
P
M
A
S
A
Q
V
K
S
C
L
L
L
A
G
L
Y
A
R
G
K
T
C
I
T
E
P
A
P
S
R
D
H
T
E
R
L
L
K
H
F
H
Y
T
L
Q
------------
S
I
C
V
S
G
G
G
K
---
L
K
A
N
D
I
S
I
P
G
D
I
S
S
A
A
F
F
I
V
A
A
T
I
T
P
G
S
-
A
I
R
L
C
R
V
G
V
N
P
T
R
L
G
V
I
N
L
L
K
M
M
G
A
D
I
E
V
T
H
Y
T
E
-
K
--
N
E
-
P
T
A
D
I
T
V
R
H
A
R
L
K
G
I
D
I
P
-
P
D
-
Q
V
-
P
L
T
I
D
E
F
P
V
L
L
I
A
A
A
V
A
Q
G
K
T
V
L
R
D
A
A
E
L
R
V
K
E
T
D
R
I
A
A
M
V
D
G
L
Q
K
L
G
I
A
A
E
S
L
P
D
G
V
I
I
Q
G
-----------
G
T
L
E
G
G
E
V
N
S
Y
D
D
H
R
I
A
M
A
F
A
V
A
G
T
L
A
K
G
-
P
V
R
I
R
N
C
D
N
V
K
T
S
F
P
N
F
V
E
L
A
N
E
V
G
M
N
V
K
G
V
R
G
R
---
29
PsiBlast_CBE
93.16
39%
-90
- C8 -
3SLH
16
AROA_COXBU
D:
[22-440]
--------
G
D
K
S
I
S
H
R
A
V
L
L
A
A
I
A
E
G
Q
T
Q
V
D
G
F
L
M
G
A
D
N
L
A
M
V
S
A
L
Q
Q
M
G
A
S
I
Q
V
I
E
D
-
E
-
N
I
L
V
--
V
E
---
G
VGM
T
--
G
L
Q
A
P
P
E
A
L
D
C
G
N
S
G
T
A
I
R
L
L
S
G
L
L
A
G
Q
P
F
N
T
V
L
T
G
D
S
S
L
Q
R
R
P
M
K
R
I
I
D
P
L
T
L
M
G
A
K
I
--
D
S
T
G
N
V
P
P
L
K
I
Y
G
N
-
P
R
L
T
G
-
I
H
Y
Q
L
P
M
A
S
A
Q
V
K
S
C
L
L
L
A
G
L
Y
A
R
G
K
T
C
I
T
E
P
A
P
S
R
D
H
T
E
R
L
L
K
H
F
H
Y
T
L
Q
---
K
D
K
Q
-----
S
I
C
V
S
G
G
G
K
---
L
K
A
N
D
I
S
I
P
G
D
I
S
S
A
A
F
F
I
V
A
A
T
I
T
P
G
S
-
A
I
R
L
C
R
V
G
V
N
P
T
R
L
G
V
I
N
L
L
K
M
M
G
A
D
I
E
V
T
H
Y
T
E
-
K
--
N
E
E
P
T
A
D
I
T
V
R
H
A
R
L
K
G
I
D
I
P
-
P
D
-
Q
V
-
P
L
T
I
D
E
F
P
V
L
L
I
A
A
A
V
A
Q
G
K
T
V
L
R
D
A
A
E
L
R
V
K
E
T
D
R
I
A
A
M
V
D
G
L
Q
K
L
G
I
A
A
E
S
L
P
D
G
V
I
I
Q
G
-----------
G
T
L
E
G
G
E
V
N
S
Y
D
D
H
R
I
A
M
A
F
A
V
A
G
T
L
A
K
G-
P
V
R
I
R
N
C
D
N
V
K
T
S
F
P
N
F
VELAN
E
V
G
M
N
V
K
G
V
R
G
R
G
G
F
23
PsiBlast_CBE
93.10
38%
-99
- C8 -
3RMT
8
AROA1_BACHD
B:
[23-436]
--------
G
D
K
S
I
S
H
R
A
V
M
F
G
A
L
A
K
G
T
T
T
V
E
G
F
L
P
G
A
D
C
L
S
T
I
S
C
F
Q
K
L
G
V
S
I
E
Q
A
E
E
-
R
V
T
V
K
G
--
K
G
---
W
---
D
--
G
L
R
E
P
S
D
I
L
D
V
G
N
S
G
T
T
T
R
L
I
L
G
I
L
S
T
L
P
F
H
S
V
I
I
G
D
E
S
I
G
K
R
P
M
K
R
V
T
E
P
L
K
S
M
G
A
Q
I
D
G
R
D
H
G
N
L
T
P
L
S
I
R
G
G
-
Q
-
L
K
G
-
I
D
F
H
S
P
V
A
S
A
Q
M
K
S
A
I
L
L
A
G
L
R
A
E
G
K
T
S
V
T
E
P
A
K
T
R
D
H
T
E
R
M
L
E
A
F
G
V
N
I
E
----
K
D
G
-----
L
T
V
S
I
E
G
G
Q
--
M
L
T
G
Q
H
V
V
V
P
G
D
I
S
S
A
A
F
F
L
V
A
G
A
M
V
P
H
S
-
R
I
T
L
T
N
V
G
I
N
P
T
R
A
G
I
L
E
V
L
K
Q
M
G
A
T
L
A
M
E
-
N
E
R
V
Q
--
G
G
E
P
V
A
D
L
T
I
E
T
S
V
L
Q
G
V
E
I
G
-
G
D
I
I
P
-
R
L
-
I
D
E
I
P
I
I
A
V
L
A
T
Q
A
S
G
R
T
V
I
K
D
A
E
E
-----
T
N
R
I
D
T
V
V
S
E
L
T
K
L
G
A
S
I
H
A
T
D
D
G
M
I
I
E
G
---
P
T
P
L
K
G
G
V
T
------
V
S
S
H
G
D
H
R
I
G
M
A
M
A
I
A
-
A
L
L
A
E
K
P
V
T
V
E
G
T
E
A
I
A
V
S
Y
P
S
F
-----
F
D
H
L
D
R
L
K
S
E
A
E
N
L
Y
45
HHSearch
92.88
40%
-92
* C8 *
3SLH
12
AROA_COXBU
A:
[15-433]
-
S
G
E
I
C
V
P
G
D
K
S
I
S
H
R
A
V
L
L
A
A
I
A
E
G
Q
T
Q
V
D
G
F
L
M
G
A
D
N
L
A
M
V
S
A
L
Q
Q
M
G
A
S
I
Q
V
I
E
D
E
N
-
I
L
V
V
--
E
G
---
V
---
G
MT
G
L
Q
A
P
P
E
A
L
D
C
G
N
S
G
T
A
I
R
L
L
S
G
L
L
A
G
Q
P
F
N
T
V
L
T
G
D
S
S
L
Q
R
R
P
M
K
R
I
I
D
P
L
T
L
M
G
A
K
I
D
S
T
--
G
N
V
P
P
L
K
I
Y
G
N
P
R
-
L
T
G
-
I
H
Y
Q
L
P
M
A
S
A
Q
V
K
S
C
L
L
L
A
G
L
Y
A
R
G
K
T
C
I
T
E
P
A
P
S
R
D
H
T
E
R
L
L
K
H
F
H
Y
T
L
Q
---
K
D
K
Q
-----
S
I
C
V
-
S
G
G
G
--
K
L
K
A
N
D
I
S
I
P
G
D
I
S
S
A
A
F
F
I
V
A
A
T
I
T
P
-
G
S
A
I
R
L
C
R
V
G
V
N
P
T
R
L
G
V
I
N
L
L
K
M
M
G
A
D
I
E
V
T
-
H
Y
T
E
K
--
N
E
E
P
T
A
D
I
T
V
R
H
A
R
L
K
G
I
D
I
P
P
D
Q
-
V
P
-
L
T
-
I
D
E
F
P
V
L
L
I
A
A
A
V
A
Q
G
K
T
V
L
R
D
A
A
E
L
R
V
K
E
T
D
R
I
A
A
M
V
D
G
L
Q
K
L
G
I
A
A
E
S
L
P
D
G
V
I
I
Q
G
G
T
L
-----------
E
G
G
E
V
N
S
Y
D
D
H
R
I
A
M
A
F
A
V
A
-
G
T
L
A
K
G
P
V
R
I
R
N
C
D
N
V
K
T
S
F
P
N
F
-----
V
E
L
A
N
E
V
G
M
N
V
K
G
V
R
3
PsiBlast_PDB
92.31
39%
-92
- C8 -
3SLH
13
AROA_COXBU
A:
[22-438]
--------
G
D
K
S
I
S
H
R
A
V
L
L
A
A
I
A
E
G
Q
T
Q
V
D
G
F
L
M
G
A
D
N
L
A
M
V
S
A
L
Q
Q
M
G
A
S
I
Q
V
I
E
D
-
E
-
N
I
L
V
--
V
E
---
G
VGM
T
--
G
L
Q
A
P
P
E
A
L
D
C
G
N
S
G
T
A
I
R
L
L
S
G
L
L
A
G
Q
P
F
N
T
V
L
T
G
D
S
S
L
Q
R
R
P
M
K
R
I
I
D
P
L
T
L
M
G
A
K
I
--
D
S
T
G
N
V
P
P
L
K
I
Y
G
N
-
P
R
L
T
G
-
I
H
Y
Q
L
P
M
A
S
A
Q
V
K
S
C
L
L
L
A
G
L
Y
A
R
G
K
T
C
I
T
E
P
A
P
S
R
D
H
T
E
R
L
L
K
H
F
H
Y
T
L
Q
---
K
D
K
Q
-----
S
I
C
V
S
G
G
G
K
---
L
K
A
N
D
I
S
I
P
G
D
I
S
S
A
A
F
F
I
V
A
A
T
I
T
P
G
S
-
A
I
R
L
C
R
V
G
V
N
P
T
R
L
G
V
I
N
L
L
K
M
M
G
A
D
I
E
V
T
H
Y
T
E
-
K
--
N
E
E
P
T
A
D
I
T
V
R
H
A
R
L
K
G
I
D
I
P
-
P
D
-
Q
V
-
P
L
T
I
D
E
F
P
V
L
L
I
A
A
A
V
A
Q
G
K
T
V
L
R
D
A
A
E
L
R
V
K
E
T
D
R
I
A
A
M
V
D
G
L
Q
K
L
G
I
A
A
E
S
L
P
D
G
V
I
I
Q
G
-----------
G
T
L
E
G
G
E
V
N
S
Y
D
D
H
R
I
A
M
A
F
A
V
A
G
T
L
A
K
G
-
P
V
R
I
R
N
C
D
N
V
K
T
S
F
P
N
F
V
E
L
A
N
E
V
G
M
N
V
K
G
V
R
G
R
---
6
PsiBlast_PDB
92.12
39%
-96
- C8 -
3TR1
6
AROA_COXBU
A:
[22-421]
--------
G
D
K
S
I
S
H
R
A
V
L
L
A
A
I
A
E
G
Q
T
Q
V
D
G
F
L
M
G
A
D
N
L
A
M
V
S
A
L
Q
Q
M
G
A
S
I
Q
V
I
E
D
-
E
-
N
I
L
V
--
V
E
GVG
M
---
T
--
G
L
Q
A
P
P
E
A
L
D
C
G
N
S
G
T
A
I
R
L
L
S
G
L
L
A
G
Q
P
F
N
T
V
L
T
G
D
S
S
L
Q
R
R
P
M
K
R
I
I
D
P
L
T
L
M
G
A
K
I
--
D
S
T
G
N
V
P
P
L
K
I
Y
G
N
-
P
R
L
T
G
-
I
H
Y
Q
L
P
M
A
S
A
Q
V
K
S
C
L
L
L
A
G
L
Y
A
R
G
K
T
C
I
T
E
P
A
P
S
R
D
H
T
E
R
L
L
K
H
F
H
Y
T
L
Q
---
K
-
K
Q
-----
S
I
C
V
S
G
G
G
K
---
L
K
A
N
D
I
S
I
P
G
D
I
S
S
A
A
F
F
I
V
A
A
T
I
T
P
G
S
-
A
I
R
L
C
R
V
G
V
N
P
T
R
L
G
V
I
N
L
L
K
M
M
G
A
D
I
E
V
T
H
Y
T
E
-
K
--
N
E
E
P
T
A
D
I
T
V
R
H
A
R
L
K
G
I
D
I
P
-
P
D
-
Q
V
-
P
L
T
I
D
E
F
P
V
L
L
I
A
A
A
V
A
Q
G
K
T
V
L
R
D
A
A
E
L
R
V
K
E
T
D
R
I
A
A
M
V
D
G
L
Q
K
L
G
I
A
A
E
S
L
P
D
G
V
I
I
Q
G
-----------
G
T
L
E
G
G
E
V
N
S
Y
D
D
H
R
I
A
M
A
F
A
V
A
G
T
L
A
K
G
-
P
V
R
I
R
N
C
D
N
V
K
T
S
F
P
N
F
-----
V
E
L
A
N
E
V
G
M
N
V
K
G
V
R
22
PsiBlast_CBE
91.85
38%
-100
- C8 -
3RMT
6
AROA1_BACHD
C:
[23-436]
--------
G
D
K
S
I
S
H
R
A
V
M
F
G
A
L
A
K
G
T
T
T
V
E
G
F
L
P
G
A
D
C
L
S
T
I
S
C
F
Q
K
L
G
V
S
I
E
Q
A
E
E
-
R
V
T
V
K
G
--
K
G
---
W
---
D
--
G
L
R
E
P
S
D
I
L
D
V
G
N
S
G
T
T
T
R
L
I
L
G
I
L
S
T
L
P
F
H
S
V
I
I
G
D
E
S
I
G
K
R
P
M
K
R
V
T
E
P
L
K
S
M
G
A
Q
I
D
G
R
D
H
G
N
L
T
P
L
S
I
R
G
G
-
Q
-
L
K
G
-
I
D
F
H
S
P
V
A
S
A
Q
M
K
S
A
I
L
L
A
G
L
R
A
E
G
K
T
S
V
T
E
P
A
K
T
R
D
H
T
E
R
M
L
E
A
F
G
V
N
I
E
----
K
D
G
-----
L
T
V
S
I
E
G
G
Q
--
M
L
T
G
Q
H
V
V
V
P
G
D
I
S
S
A
A
F
F
L
V
A
G
A
M
V
P
H
S
-
R
I
T
L
T
N
V
G
I
N
P
T
R
A
G
I
L
E
V
L
K
Q
M
G
A
T
L
A
M
E
-
N
E
R
V
Q
--
G
G
E
P
V
A
D
L
T
I
E
T
S
V
L
Q
G
V
E
I
G
-
G
D
I
I
P
-
R
L
-
I
D
E
I
P
I
I
A
V
L
A
T
Q
A
S
G
R
T
V
I
K
D
A
E
E
L
K
V
K
E
T
N
R
I
D
T
V
V
S
E
L
T
K
L
G
A
S
I
H
A
T
D
D
G
M
I
I
E
G
---
P
T
P
L
K
G
G
V
T
------
V
S
S
H
G
D
H
R
I
G
M
A
M
A
I
A
-
A
L
L
A
E
K
P
V
T
V
E
G
T
E
A
I
A
V
S
Y
P
S
F
-----
F
D
H
L
D
R
L
K
S
E
A
E
N
L
Y
43
HHSearch
91.82
32%
-92
- C8 -
2PQC
1
AROA_AGRSC
A:
[14-442]
-
S
G
T
V
R
I
P
G
D
K
S
I
S
H
R
S
F
M
F
G
G
L
A
S
G
E
T
R
I
T
G
L
L
E
G
E
D
V
I
N
T
G
K
A
M
Q
A
M
G
A
R
I
R
K
E
G
--
D
-
T
W
I
I
--
D
G
---
V
---
G
NG
G
L
L
A
P
E
A
P
L
D
F
G
N
A
A
T
G
C
R
L
T
M
G
L
V
G
V
Y
D
F
D
S
T
F
I
G
D
A
S
L
T
K
R
P
M
G
R
V
L
N
P
L
R
E
M
G
V
Q
V
K
S
E
-
D
G
D
R
L
P
V
T
L
R
G
P
K
T
-
P
T
P
-
I
T
Y
R
V
P
M
A
S
A
Q
V
K
S
A
V
L
L
A
G
L
N
T
P
G
I
T
T
V
I
E
P
I
M
T
R
D
H
T
E
K
M
L
Q
G
F
G
A
N
L
T
---
V
E
T
D
ADG
V
R
T
I
R
L
-
E
G
R
G
--
K
L
T
G
Q
V
I
D
V
P
G
D
P
S
S
T
A
F
P
L
V
A
A
L
L
V
P
G
S
-
D
V
T
I
L
N
V
L
M
N
P
T
R
T
G
L
I
L
T
L
Q
E
M
G
A
D
I
E
V
I
-
N
P
R
L
A
--
G
G
E
D
V
A
D
L
R
V
R
S
S
T
L
K
G
V
T
V
P
E
D
R
-
A
P
-
S
M
-
I
D
E
Y
P
I
L
A
V
A
A
A
F
A
E
G
A
T
V
M
N
G
L
E
E
L
R
V
K
E
S
D
R
L
S
A
V
A
N
G
L
K
L
N
G
V
D
C
D
E
G
E
T
S
L
V
V
R
G
R
P
D
G
K
G
L
G
--
N
A
--
S
G
A
A
V
A
T
H
L
D
H
R
I
A
M
S
F
L
V
M
-
G
L
V
S
E
N
P
V
T
V
D
D
A
T
M
I
A
T
S
F
P
E
F
-----
M
D
L
M
A
G
L
G
A
K
I
E
L
S
-
1
PsiBlast_PDB
91.00
38%
-102
- C8 -
3RMT
9
AROA1_BACHD
A:
[23-436]
--------
G
D
K
S
I
S
H
R
A
V
M
F
G
A
L
A
K
G
T
T
T
V
E
G
F
L
P
G
A
D
C
L
S
T
I
S
C
F
Q
K
L
G
V
S
I
E
Q
A
E
E
-
R
V
T
V
K
G
--
K
G
---
W
---
D
--
G
L
R
E
P
S
D
I
L
D
V
G
N
S
G
T
T
T
R
L
I
L
G
I
L
S
T
L
P
F
H
S
V
I
I
G
D
E
S
I
G
K
R
P
M
K
R
V
T
E
P
L
K
S
M
G
A
Q
I
D
G
R
D
H
G
N
L
T
P
L
S
I
R
G
G
-
Q
-
L
K
G
-
I
D
F
H
S
P
V
A
S
A
Q
M
K
S
A
I
L
L
A
G
L
R
A
E
G
K
T
S
V
T
E
P
A
K
T
R
D
H
T
E
R
M
L
E
A
F
G
V
N
I
E
----
K
D
G
-----
L
T
V
S
I
E
G
G
Q
--
M
L
T
G
Q
H
V
V
V
P
G
D
I
S
S
A
A
F
F
L
V
A
G
A
M
V
P
H
S
-
R
I
T
L
T
N
V
G
I
N
P
T
R
A
G
I
L
E
V
L
K
Q
M
G
A
T
L
A
M
E
-
N
E
R
V
Q
--
G
G
E
P
V
A
D
L
T
I
E
T
S
V
L
Q
G
V
E
I
G
-
G
D
I
I
P
-
R
L
-
I
D
E
I
P
I
I
A
V
L
A
T
Q
A
S
G
R
T
V
I
K
D
-----
V
K
E
T
N
R
I
D
T
V
V
S
E
L
T
K
L
G
A
S
I
H
A
T
D
D
G
M
I
I
E
G
---
P
T
P
L
K
G
G
V
T
------
V
S
S
H
G
D
H
R
I
G
M
A
M
A
I
A
-
A
L
L
A
E
K
P
V
T
V
E
G
T
E
A
I
A
V
S
Y
P
S
F
-----
F
D
H
L
D
R
L
K
S
E
A
E
N
L
Y
21
PsiBlast_CBE
90.70
38%
-99
- C8 -
3RMT
3
AROA1_BACHD
D:
[23-436]
--------
G
D
K
S
I
S
H
R
A
V
M
F
G
A
L
A
K
G
T
T
T
V
E
G
F
L
P
G
A
D
C
L
S
T
I
S
C
F
Q
K
L
G
V
S
I
E
Q
A
E
E
-
R
V
T
V
K
G
--
K
G
---
W
---
D
--
G
L
R
E
P
S
D
I
L
D
V
G
N
S
G
T
T
T
R
L
I
L
G
I
L
S
T
L
P
F
H
S
V
I
I
G
D
E
S
I
G
K
R
P
M
K
R
V
T
E
P
L
K
S
M
G
A
Q
I
D
G
R
D
H
G
N
L
T
P
L
S
I
R
G
G
-
Q
-
L
K
G
-
I
D
F
H
S
P
V
A
S
A
Q
M
K
S
A
I
L
L
A
G
L
R
A
E
G
K
T
S
V
T
E
P
A
K
T
R
D
H
T
E
R
M
L
E
A
F
G
V
N
I
E
----
K
D
G
-----
L
T
V
S
I
E
G
G
Q
--
M
L
T
G
Q
H
V
V
V
P
G
D
I
S
S
A
A
F
F
L
V
A
G
A
M
V
P
H
S
-
R
I
T
L
T
N
V
G
I
N
P
T
R
A
G
I
L
E
V
L
K
Q
M
G
A
T
L
A
M
E
-
N
E
R
V
Q
--
G
G
E
P
V
A
D
L
T
I
E
T
S
V
L
Q
G
V
E
I
G
-
G
D
I
I
P
-
R
L
-
I
D
E
I
P
I
I
A
V
L
A
T
Q
A
S
G
R
T
V
I
K
D
A
E
E
-----
T
N
R
I
D
T
V
V
S
E
L
T
K
L
G
A
S
I
H
A
T
D
D
G
M
I
I
E
G
---
P
T
P
L
K
G
G
V
T
------
V
S
S
H
G
D
H
R
I
G
M
A
M
A
I
A
-
A
L
L
A
EK
P
V
T
V
E
G
T
E
A
I
A
V
S
Y
P
S
F
-----
F
D
H
L
D
R
L
K
S
E
A
E
N
L
Y
10
PsiBlast_PDB
88.91
34%
-93
- C8 -
2PQD
1
AROA_AGRSC
A:
[21-431]
--------
G
D
K
S
I
S
H
R
S
F
M
F
G
G
L
A
S
G
E
T
R
I
T
G
L
L
E
G
E
D
V
I
N
T
G
K
A
M
Q
A
M
G
A
R
I
R
K
E
G
--
D
-
T
W
I
I
D
G
V
G
---
N
---
G
--
G
L
L
A
P
E
A
P
L
D
F
G
N
A
G
T
G
C
R
L
T
M
G
L
V
G
V
Y
D
F
D
S
T
F
I
G
D
A
S
L
T
K
R
P
M
G
R
V
L
N
P
L
R
E
M
G
V
Q
V
K
-
S
E
D
G
D
R
L
P
V
T
L
R
G
P
-
K
-
T
P
T
P
I
T
Y
R
V
P
M
A
S
A
Q
V
K
S
A
V
L
L
A
G
L
N
T
P
G
I
T
T
V
I
E
P
I
M
T
R
D
H
T
E
K
M
L
Q
G
F
G
A
N
L
T
V
E
T
D
A
D
G
-----
V
R
T
I
R
-
L
E
G
R
G
K
L
T
G
Q
V
I
D
V
P
G
D
P
S
S
T
A
F
P
L
V
A
A
L
L
V
P
G
S
-
D
V
T
I
L
N
V
L
M
N
P
T
R
T
G
L
I
L
T
L
Q
E
M
G
A
D
I
E
-
V
-
I
N
P
-
R
L
A
G
G
E
D
V
A
D
L
R
V
R
S
S
T
L
K
G
V
T
V
P
-
E
D
-
R
A
P
S
M
-
I
D
E
Y
P
I
L
A
V
A
A
A
F
A
E
G
A
T
V
M
N
G
L
E
E
L
R
V
K
E
S
D
R
L
S
A
V
A
N
G
L
K
L
N
G
V
D
C
D
E
G
E
T
S
L
V
V
R
G
R
P
D
G
K
G
L
G
N
A
S
G
A
----
A
V
A
T
H
L
D
H
R
I
A
M
S
F
L
V
M
-
G
L
V
S
E
N
P
V
T
V
D
D
A
T
M
I
A
T
S
F
P
E
F
-----
M
D
L
M
A
G
L
G
A
K
I
E
L
S
-
15
PsiBlast_PDB
88.55
33%
-92
- C8 -
2GG6
2
AROA_AGRSC
A:
[26-436]
--------
G
D
K
S
I
S
H
R
S
F
M
F
G
G
L
A
S
G
E
T
R
I
T
G
L
L
E
G
E
D
V
I
N
T
G
K
A
M
Q
A
M
G
A
R
I
R
K
E
G
--
D
-
T
W
I
I
D
G
V
G
---
N
---
G
--
G
L
L
A
P
E
A
P
L
D
F
G
N
A
A
T
G
C
R
L
T
M
G
L
V
G
V
Y
D
F
D
S
T
F
I
G
D
A
S
L
T
K
R
P
M
G
R
V
L
N
P
L
R
E
M
G
V
Q
V
K
-
S
E
D
G
D
R
L
P
V
T
L
R
G
P
-
K
-
T
P
T
P
I
T
Y
R
V
P
M
A
S
A
Q
V
K
S
A
V
L
L
A
G
L
N
T
P
G
I
T
T
V
I
E
P
I
M
T
R
D
H
T
E
K
M
L
Q
G
F
G
A
N
L
T
V
E
T
D
A
D
G
-----
V
R
T
I
R
-
L
E
G
R
G
K
L
T
G
Q
V
I
D
V
P
G
D
P
S
S
T
A
F
P
L
V
A
A
L
L
V
P
G
S
-
D
V
T
I
L
N
V
L
M
N
P
T
R
T
G
L
I
L
T
L
Q
E
M
G
A
D
I
E
-
V
-
I
N
P
-
R
L
A
G
G
E
D
V
A
D
L
R
V
R
S
S
T
L
K
G
V
T
V
P
-
E
D
-
R
A
P
S
M
-
I
D
E
Y
P
I
L
A
V
A
A
A
F
A
E
G
A
T
V
M
N
G
L
E
E
L
R
V
K
E
S
D
R
L
S
A
V
A
N
G
L
K
L
N
G
V
D
C
D
E
G
E
T
S
L
V
V
R
G
R
P
D
G
K
G
L
G
N
A
S
G
A
----
A
V
A
T
H
L
D
H
R
I
A
M
S
F
L
V
M
-
G
L
V
S
E
N
P
V
T
V
D
D
A
T
M
I
A
T
S
F
P
E
F
-----
M
D
L
M
A
G
L
G
A
K
I
E
L
S
-
13
PsiBlast_PDB
88.50
33%
-93
- C8 -
2PQC
1
AROA_AGRSC
A:
[21-431]
--------
G
D
K
S
I
S
H
R
S
F
M
F
G
G
L
A
S
G
E
T
R
I
T
G
L
L
E
G
E
D
V
I
N
T
G
K
A
M
Q
A
M
G
A
R
I
R
K
E
G
--
D
-
T
W
I
I
D
G
V
G
---
N
---
G
--
G
L
L
A
P
E
A
P
L
D
F
G
N
A
A
T
G
C
R
L
T
M
G
L
V
G
V
Y
D
F
D
S
T
F
I
G
D
A
S
L
T
K
R
P
M
G
R
V
L
N
P
L
R
E
M
G
V
Q
V
K
-
S
E
D
G
D
R
L
P
V
T
L
R
G
P
-
K
-
T
P
T
P
I
T
Y
R
V
P
M
A
S
A
Q
V
K
S
A
V
L
L
A
G
L
N
T
P
G
I
T
T
V
I
E
P
I
M
T
R
D
H
T
E
K
M
L
Q
G
F
G
A
N
L
T
V
E
T
D
A
D
G
-----
V
R
T
I
R
-
L
E
G
R
G
K
L
T
G
Q
V
I
D
V
P
G
D
P
S
S
T
A
F
P
L
V
A
A
L
L
V
P
G
S
-
D
V
T
I
L
N
V
L
M
N
P
T
R
T
G
L
I
L
T
L
Q
E
M
G
A
D
I
E
-
V
-
I
N
P
-
R
L
A
G
G
E
D
V
A
D
L
R
V
R
S
S
T
L
K
G
V
T
V
P
-
E
D
-
R
A
P
S
M
-
I
D
E
Y
P
I
L
A
V
A
A
A
F
A
E
G
A
T
V
M
N
G
L
E
E
L
R
V
K
E
S
D
R
L
S
A
V
A
N
G
L
K
L
N
G
V
D
C
D
E
G
E
T
S
L
V
V
R
G
R
P
D
G
K
G
L
G
N
A
S
G
A
----
A
V
A
T
H
L
D
H
R
I
A
M
S
F
L
V
M
-
G
L
V
S
E
N
P
V
T
V
D
D
A
T
M
I
A
T
S
F
P
E
F
-----
M
D
L
M
A
G
L
G
A
K
I
E
L
S
-
11
PsiBlast_PDB
88.25
34%
-92
- C8 -
2GGD
2
AROA_AGRSC
A:
[26-436]
--------
G
D
K
S
I
S
H
R
S
F
M
F
G
G
L
A
S
G
E
T
R
I
T
G
L
L
E
G
E
D
V
I
N
T
G
K
A
M
Q
A
M
G
A
R
I
R
K
E
G
--
D
-
T
W
I
I
DG
V
G
---
N
---
G
--
G
L
L
A
P
E
A
P
L
D
F
G
N
A
G
T
G
C
R
L
T
M
G
L
V
G
V
Y
D
F
D
S
T
F
I
G
D
A
S
L
T
K
R
P
M
G
R
V
L
N
P
L
R
E
M
G
V
Q
V
K
-
S
E
D
G
D
R
L
P
V
T
L
R
G
P
-
K
-
T
P
T
P
I
T
Y
R
V
P
M
A
S
A
Q
V
K
S
A
V
L
L
A
G
L
N
T
P
G
I
T
T
V
I
E
P
I
M
T
R
D
H
T
E
K
M
L
Q
G
F
G
A
N
L
T
V
E
T
D
A
D
G
-----
V
R
T
I
R
-
L
E
G
R
G
K
L
T
G
Q
V
I
D
V
P
G
D
P
S
S
T
A
F
P
L
V
A
A
L
L
V
P
G
S
-
D
V
T
I
L
N
V
L
M
N
P
T
R
T
G
L
I
L
T
L
Q
E
M
G
A
D
I
E
-
V
-
I
N
P
-
R
L
A
G
G
E
D
V
A
D
L
R
V
R
S
S
T
L
K
G
V
T
V
P
-
E
D
-
R
A
P
S
M
-
I
D
E
Y
P
I
L
A
V
A
A
A
F
A
E
G
A
T
V
M
N
G
L
E
E
L
R
V
K
E
S
D
R
L
S
A
V
A
N
G
L
K
L
N
G
V
D
C
D
E
G
E
T
S
L
V
V
R
G
R
P
D
G
K
G
L
G
N
A
S
G
A
----
A
V
A
T
H
L
D
H
R
I
A
M
S
F
L
V
M
-
G
L
V
S
E
N
P
V
T
V
D
D
A
T
M
I
A
T
S
F
P
E
F
-----
M
D
L
M
A
G
L
G
A
K
I
E
L
S
-
16
PsiBlast_PDB
88.08
33%
-92
- C8 -
2GGA
2
AROA_AGRSC
A:
[26-436]
--------
G
D
K
S
I
S
H
R
S
F
M
F
G
G
L
A
S
G
E
T
R
I
T
G
L
L
E
G
E
D
V
I
N
T
G
K
A
M
Q
A
M
G
A
R
I
R
K
E
G
--
D
-
T
W
I
I
DG
V
G
---
N
---
G
--
G
L
L
A
P
E
A
P
L
D
F
G
N
A
A
T
G
C
R
L
T
M
G
L
V
G
V
Y
D
F
D
S
T
F
I
G
D
A
S
L
T
K
R
P
M
G
R
V
L
N
P
L
R
E
M
G
V
Q
V
K
-
S
E
D
G
D
R
L
P
V
T
L
R
G
P
-
K
-
T
P
T
P
I
T
Y
R
V
P
M
A
S
A
Q
V
K
S
A
V
L
L
A
G
L
N
T
P
G
I
T
T
V
I
E
P
I
M
T
R
D
H
T
E
K
M
L
Q
G
F
G
A
N
L
T
V
E
T
D
A
D
G
-----
V
R
T
I
R
-
L
E
G
R
G
K
L
T
G
Q
V
I
D
V
P
G
D
P
S
S
T
A
F
P
L
V
A
A
L
L
V
P
G
S
-
D
V
T
I
L
N
V
L
M
N
P
T
R
T
G
L
I
L
T
L
Q
E
M
G
A
D
I
E
-
V
-
I
N
P
-
R
L
A
G
G
E
D
V
A
D
L
R
V
R
S
S
T
L
K
G
V
T
V
P
-
E
D
-
R
A
P
S
M
-
I
D
E
Y
P
I
L
A
V
A
A
A
F
A
E
G
A
T
V
M
N
G
L
E
E
L
R
V
K
E
S
D
R
L
S
A
V
A
N
G
L
K
L
N
G
V
D
C
D
E
G
E
T
S
L
V
V
R
G
R
P
D
G
K
G
L
G
N
A
S
G
A
----
A
V
A
T
H
L
D
H
R
I
A
M
S
F
L
V
M
-
G
L
V
S
E
N
P
V
T
V
D
D
A
T
M
I
A
T
S
F
P
E
F
-----
M
D
L
M
A
G
L
G
A
K
I
E
L
S
-
12
PsiBlast_PDB
87.69
33%
-92
- C8 -
2PQB
1
AROA_AGRSC
A:
[21-431]
--------
G
D
K
S
I
S
H
R
S
F
M
F
G
G
L
A
S
G
E
T
R
I
T
G
L
L
E
G
E
D
V
I
N
T
G
K
A
M
Q
A
M
G
A
R
I
R
K
E
G
--
D
-
T
W
I
I
D
G
V
G
---
N
---
G
--
G
L
L
A
P
E
A
P
L
D
F
G
N
A
A
T
G
C
R
L
T
M
G
L
V
G
V
Y
D
F
D
S
T
F
I
G
D
A
S
L
T
K
R
P
M
G
R
V
L
N
P
L
R
E
M
G
V
Q
V
K
-
S
E
D
G
D
R
L
P
V
T
L
R
G
P
-
K
-
T
P
T
P
I
T
Y
R
V
P
M
A
S
A
Q
V
K
S
A
V
L
L
A
G
L
N
T
P
G
I
T
T
V
I
E
P
I
M
T
R
D
H
T
E
K
M
L
Q
G
F
G
A
N
L
T
V
E
T
D
A
D
G
-----
V
R
T
I
R
-
L
E
G
R
G
K
L
T
G
Q
V
I
D
V
P
G
D
P
S
S
T
A
F
P
L
V
A
A
L
L
V
P
G
S
-
D
V
T
I
L
N
V
L
M
N
P
T
R
T
G
L
I
L
T
L
Q
E
M
G
A
D
I
E
-
V
-
I
N
P
-
R
L
A
G
G
E
D
V
A
D
L
R
V
R
S
S
T
L
K
G
V
T
V
P
-
E
D
-
R
A
P
S
M
-
I
D
E
Y
P
I
L
A
V
A
A
A
F
A
E
G
A
T
V
M
N
G
L
E
E
L
R
V
K
E
S
D
R
L
S
A
V
A
N
G
L
K
L
N
G
V
D
C
D
E
G
E
T
S
L
V
V
R
G
R
P
D
G
K
G
L
G
N
A
S
G
A
----
A
V
A
T
H
L
D
H
R
I
A
M
S
F
L
V
M
-
G
L
V
S
E
N
P
V
T
V
D
D
A
T
M
I
A
T
S
F
P
E
F
-----
M
D
L
M
A
G
L
G
A
K
I
E
L
S
-