@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_0981: (2015-12-19 )
MEIKMAKDYGFCFGVKRAIQIAEKNQNSLIFGSLIHNAKEINRLEKNFNVKIEEDPKKIPKNKSVIIRTHGIPKQDLEYLKNKGVKITDATCPYVIKPQQIVESMSKEGYQIVLFGDINHPEVKGVISYATNQALVVNSLEELQEKKLQRKVALVSQTTKQTPKLLQIASYLVERCTEVRIFNTICNATSYNQKAALDLSKEVDIMIVVGGKTSSNTKQLLSIAKQHCKDSYLVEDENELELAWFKDKKLCGITAGASTPDWIIENVKQKISTI
Atome Classification :
(23 SA)
-.........10........20...-----....-----.-30..-------......40......-..50........60........70........80........90........100.......110.......120.......---130--.---.---......140...--....150.......160.......170.......--180.......190.......200.......210.......220.......230.......240.......250.......260.......270..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-ME
I
K
M
AKDY
G
F
C
F
G
V
K
R
A
I
Q
I
A
EK-----NQN
S
-----
L
-
I
F
G
S
-------
L
IH
N
A
K
E
I
N
R
L
E
KN-F
N
V
K
IEE
D
P
K
KIPKNK
S
V
I
I
R
THGI
P
K
Q
D
L
E
Y
L
K
NKG
V
K
ITDATC
P
Y
V
I
K
P
Q
Q
I
V
E
S
M
S
KEG
Y
Q
I
V
L
F
GDIN
H
P
E
V
K
G
V
I
SY---AT---N---
Q
---
A
L
V
V
N
S
L
E
E
L
Q
E
--
K
K
L
Q
R
K
V
A
L
V
S
Q
T
T
KQT
P
K
L
L
Q
I
A
S
Y
L
V
E
R
C
T
E
V
--
R
I
F
N
T
ICNATSYNQKAALDLSKEV
D
I
M
I
V
VGGKTSS
N
T
K
Q
L
L
S
I
A
K
Q
HCKDSYLVEDENE
L
E
L
A
W
FKDK
K
L
C
G
I
TAGAS
T
P
D
W
I
I
E
N
V
K
Q
K
ISTI
42
Fugue
93.06
42%
-94
- C6 -
3DNF
2
ISPH_AQUAE
A:
[1-281]
M
V
D
I
I
I
A
E
H
A
G
F
C
F
G
V
K
R
A
V
K
L
A
E
E
-----
S
L
K
E
SQ
G
K
V
Y
-
T
L
G
P
-------
I
I
H
N
P
Q
E
V
N
R
L
K
N
L
--
G
V
F
P
S
Q
-
G
E
E
F
K
E
G
D
T
V
I
I
R
S
H
G
I
P
P
E
K
E
E
A
L
R
K
K
G
L
K
V
I
D
A
T
C
P
Y
V
K
A
V
H
E
A
V
C
Q
L
T
R
E
G
Y
F
V
V
L
V
G
E
K
N
H
P
E
V
I
G
T
L
G
Y
---
L
R
---
A
C
N
G
K
---
G
I
V
V
E
T
L
E
D
I
G
E
--
A
L
K
H
E
R
V
G
I
V
A
Q
T
T
Q
N
E
E
F
F
K
E
V
V
G
E
I
A
L
W
V
K
E
V
--
K
V
I
N
T
I
C
N
A
T
S
L
R
Q
E
S
V
K
K
L
A
P
E
V
D
V
M
I
I
I
G
G
K
N
S
G
N
T
R
R
L
Y
Y
I
S
K
E
L
N
P
N
T
Y
H
I
E
T
A
E
E
L
Q
P
E
W
F
R
G
V
K
R
V
G
I
S
A
G
A
S
T
P
D
W
I
I
E
Q
V
K
S
R
I
Q
E
I
21
PsiBlast_CBE
92.40
41%
-94
- C6 -
3DNF
2
ISPH_AQUAE
B:
[2-281]
-
V
D
I
I
I
A
E
H
A
G
F
C
F
G
V
K
R
A
V
K
L
A
E
E
-----
S
L
K
E
SQGKV
Y
-
T
L
G
P
-------
I
I
H
N
P
Q
E
V
N
R
L
-
K
N
-
L
G
V
-
F
P
S
Q
G
E
E
F
K
E
G
D
T
V
I
I
R
S
H
G
I
P
P
E
K
E
E
A
L
R
K
K
G
L
K
V
I
D
A
T
C
P
Y
V
K
A
V
H
E
A
V
C
Q
L
T
R
E
G
Y
F
V
V
L
V
G
E
K
N
H
P
E
V
I
G
T
L
G
Y
LRA
C
N
---
G
---
K
---
G
I
V
V
E
T
L
E
D
I
G
E
--
A
L
K
H
E
R
V
G
I
V
A
Q
T
T
Q
N
E
E
F
F
K
E
V
V
G
E
I
A
L
W
V
K
E
V
--
K
V
I
N
T
I
C
N
A
T
S
L
R
Q
E
S
V
K
K
L
A
P
E
V
D
V
M
I
I
I
G
G
K
N
S
G
N
T
R
R
L
Y
Y
I
S
K
E
L
N
P
N
T
Y
H
I
E
T
A
E
E
L
Q
P
E
W
F
R
G
V
K
R
V
G
I
S
A
G
A
S
T
P
D
W
I
I
E
Q
V
K
S
R
I
Q
E
I
22
HHSearch
91.46
42%
-90
- C6 -
3DNF
2
ISPH_AQUAE
A:
[2-280]
-
V
D
I
I
I
A
E
H
A
G
F
C
F
G
V
K
R
A
V
K
L
A
E
E
S
L
KES
Q
G
K
V
-----
Y
-
T
L
G
P
-------
I
I
H
N
P
Q
E
V
N
R
L
K
N
L
G
V
F
P
S
Q
---
G
E
E
F
K
E
G
D
T
V
I
I
R
S
H
G
I
P
P
E
K
E
E
A
L
R
K
K
G
L
K
V
I
D
A
T
C
P
Y
V
K
A
V
H
E
A
V
C
Q
L
T
R
E
G
Y
F
V
V
L
V
G
E
K
N
H
P
E
V
I
G
T
L
G
Y
---
L
R
A
C
N
G
---
K
---
G
I
V
V
E
T
L
E
D
I
G
E
--
A
L
K
H
E
R
V
G
I
V
A
Q
T
T
Q
N
E
E
F
F
K
E
V
V
G
E
I
A
L
W
V
K
E
V
--
K
V
I
N
T
I
C
N
A
T
S
L
R
Q
E
S
V
K
K
L
A
P
E
V
D
V
M
I
I
I
G
G
K
N
S
G
N
T
R
R
L
Y
Y
I
S
K
E
L
N
P
N
T
Y
H
I
E
T
A
E
E
L
Q
P
E
W
F
R
G
V
K
R
V
G
I
S
A
G
A
S
T
P
D
W
I
I
E
Q
V
K
S
R
I
Q
E
I
1
PsiBlast_PDB
91.04
41%
-93
- C6 -
3DNF
2
ISPH_AQUAE
A:
[2-281]
-
V
D
I
I
I
A
E
H
A
G
F
C
F
G
V
K
R
A
V
K
L
A
E
E
-----
S
L
K
E
SQ
G
K
V
Y
-
T
L
G
P
-------
I
I
H
N
P
Q
E
V
N
R
L
-
K
N
-
L
G
V
-
F
P
S
Q
G
E
E
F
K
E
G
D
T
V
I
I
R
S
H
G
I
P
P
E
K
E
E
A
L
R
K
K
G
L
K
V
I
D
A
T
C
P
Y
V
K
A
V
H
E
A
V
C
Q
L
T
R
E
G
Y
F
V
V
L
V
G
E
K
N
H
P
E
V
I
G
T
L
G
Y
L
R
A
C
N
---
G
---
K
---
G
I
V
V
E
T
L
E
D
I
G
E
--
A
L
K
H
E
R
V
G
I
V
A
Q
T
T
Q
N
E
E
F
F
K
E
V
V
G
E
I
A
L
W
V
K
E
V
--
K
V
I
N
T
I
C
N
A
T
S
L
R
Q
E
S
V
K
K
L
A
P
E
V
D
V
M
I
I
I
G
G
K
N
S
G
N
T
R
R
L
Y
Y
I
S
K
E
L
N
P
N
T
Y
H
I
E
T
A
E
E
L
Q
P
E
W
F
R
G
V
K
R
V
G
I
S
A
G
A
S
T
P
D
W
I
I
E
Q
V
K
S
R
I
Q
E
I
9
PsiBlast_PDB
82.84
30%
-67
- C6 -
4MV0
2
?
A:
[13-294]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
--------
N
A
-----
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
-
G
A
I
F
I
E
Q
-
I
S
E
V
P
D
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
---
Y
S
---
N
---
P
E
G
G
M
Y
L
V
E
S
P
D
D
V
W
K
LT
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
VG
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
10
PsiBlast_PDB
81.32
30%
-66
- C6 -
4MUX
2
?
A:
[13-294]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
--------
N
A
-----
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
-
G
A
I
F
I
E
Q
-
I
S
E
V
P
D
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
---
Y
S
---
N
---
P
E
G
G
M
Y
L
V
E
S
P
D
D
V
W
K
LT
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
8
PsiBlast_PDB
81.21
30%
-66
- C6 -
4MUY
2
?
A:
[13-294]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
--------
N
A
-----
L
A
I
Y
G
A
P
I
Y
V
RHE
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
-
G
A
I
F
I
E
Q
-
I
S
E
V
P
D
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
---
Y
S
---
N
---
P
E
G
G
M
Y
L
V
E
S
P
D
D
V
W
K
LT
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
18
PsiBlast_PDB
81.09
30%
-64
- C6 -
3UV3
2
ISPH_ECOLI
A:
[9-290]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
--------
N
A
-----
L
A
I
Y
G
A
P
I
Y
V
RHE
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
-
G
A
I
F
I
E
Q
-
I
S
E
V
P
D
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
---
Y
S
---
N
---
P
E
G
G
M
Y
L
V
E
S
P
D
D
V
W
K
LT
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
16
PsiBlast_PDB
81.04
30%
-68
- C6 -
3UTC
2
ISPH_ECOLI
A:
[9-290]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
--------
N
A
-----
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
-
G
A
I
F
I
E
Q
-
I
S
E
V
P
D
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
---
Y
S
---
N
---
P
E
G
G
M
Y
L
V
E
S
P
D
D
V
W
K
LT
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
14
PsiBlast_PDB
80.91
30%
-67
- C6 -
4H4E
2
ISPH_ECOLI
A:
[9-290]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
--------
N
A
-----
L
A
I
Y
G
A
P
I
Y
V
RHE
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
-
G
A
I
F
I
E
Q
-
I
S
E
V
P
D
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
---
Y
S
---
N
---
P
E
G
G
M
Y
L
V
E
S
P
D
D
V
W
K
LT
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
11
PsiBlast_PDB
80.88
30%
-68
- C6 -
4MV5
2
?
A:
[13-294]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
--------
N
A
-----
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
-
G
A
I
F
I
E
Q
-
I
S
E
V
P
D
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
---
Y
S
---
N
---
P
E
G
G
M
Y
L
V
E
S
P
D
D
V
W
K
LT
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
17
PsiBlast_PDB
80.84
30%
-68
- C6 -
3UTD
2
ISPH_ECOLI
A:
[9-290]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
--------
N
A
-----
L
A
I
Y
G
A
P
I
Y
V
RHE
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
-
G
A
I
F
I
E
Q
-
I
S
E
V
P
D
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
---
Y
S
---
N
---
P
E
G
G
M
Y
L
V
E
S
P
D
D
V
W
K
LT
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
19
PsiBlast_PDB
80.83
30%
-67
- C6 -
3UV6
2
ISPH_ECOLI
A:
[9-290]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
--------
N
A
-----
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
-
G
A
I
F
I
E
Q
-
I
S
E
V
P
D
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
---
Y
S
---
N
---
P
E
G
G
M
Y
L
V
E
S
P
D
D
V
W
K
LT
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
3
PsiBlast_PDB
80.60
30%
-67
- C6 -
3ZGN
2
ISPH_ECOLI
A:
[17-298]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
--------
N
A
-----
L
A
I
Y
G
A
P
I
Y
V
RHE
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
-
G
A
I
F
I
E
Q
-
I
S
E
V
P
D
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
---
Y
S
---
N
---
P
E
G
G
M
Y
L
V
E
S
P
D
D
V
W
K
LT
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
12
PsiBlast_PDB
80.55
30%
-64
- C6 -
4H4C
2
ISPH_ECOLI
A:
[9-290]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
--------
N
A
-----
L
A
I
Y
G
A
PIYVRHE
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
-
G
A
I
F
I
E
Q
-
I
S
E
V
P
D
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
---
Y
S
---
N
---
P
E
G
G
M
Y
L
V
E
S
P
D
D
V
W
K
LT
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
2
PsiBlast_PDB
80.44
30%
-67
- C6 -
3ZGL
2
ISPH_ECOLI
A:
[17-298]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
--------
N
A
-----
L
A
I
Y
G
A
P
I
Y
V
RHE
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
-
G
A
I
F
I
E
Q
-
I
S
E
V
P
D
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
---
Y
S
---
N
---
P
E
G
G
M
Y
L
V
E
S
P
D
D
V
W
K
LT
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
20
PsiBlast_PDB
80.42
30%
-65
- C6 -
3UV7
2
ISPH_ECOLI
A:
[9-290]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
--------
N
A
-----
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
-
G
A
I
F
I
E
Q
-
I
S
E
V
P
D
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
---
Y
S
---
N
---
P
E
G
G
M
Y
L
V
E
S
P
D
D
V
W
K
LT
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
15
PsiBlast_PDB
80.04
30%
-65
- C6 -
3URK
2
ISPH_ECOLI
A:
[9-290]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
--------
N
A
-----
L
A
I
Y
G
A
PIYVRHE
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
-
G
A
I
F
I
E
Q
-
I
S
E
V
P
D
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
---
Y
S
---
N
---
P
E
G
G
M
Y
L
V
E
S
P
D
D
V
W
K
LT
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
7
PsiBlast_PDB
79.95
30%
-67
- C6 -
4EB3
2
ISPH_ECOLI
A:
[13-294]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
--------
N
A
-----
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
-
G
A
I
F
I
E
Q
-
I
S
E
V
P
D
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
---
Y
S
---
N
---
P
E
G
G
M
Y
L
V
E
S
P
D
D
V
W
K
LT
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
4
PsiBlast_PDB
79.87
30%
-65
- C6 -
3F7T
7
ISPH_ECOLI
A:
[13-294]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
--------
N
A
-----
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
-
G
A
I
F
I
E
Q
-
I
S
E
V
P
D
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
---
Y
S
---
N
---
P
E
G
G
M
Y
L
V
E
S
P
D
D
V
W
K
LT
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
5
PsiBlast_PDB
79.86
30%
-66
- C6 -
3SZL
2
ISPH_ECOLI
A:
[13-294]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
--------
N
A
-----
L
A
I
Y
G
A
P
I
Y
V
RHE
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
-
G
A
I
F
I
E
Q
-
I
S
E
V
P
D
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
---
Y
S
---
N
---
P
E
G
G
M
Y
L
V
E
S
P
D
D
V
W
K
LT
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
13
PsiBlast_PDB
79.76
30%
-66
- C6 -
4H4D
2
ISPH_ECOLI
A:
[9-290]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
--------
N
A
-----
L
A
I
Y
G
A
P
I
Y
V
RHE
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
-
G
A
I
F
I
E
Q
-
I
S
E
V
P
D
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
---
Y
S
---
N
---
P
E
G
G
M
Y
L
V
E
S
P
D
D
V
W
K
LT
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
6
PsiBlast_PDB
79.63
30%
-64
- C6 -
3SZO
2
ISPH_ECOLI
A:
[13-294]
-
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
--------
N
A
-----
L
A
I
Y
G
A
P
I
Y
V
RHE
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
-
G
A
I
F
I
E
Q
-
I
S
E
V
P
D
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
---
Y
S
---
N
---
P
E
G
G
M
Y
L
V
E
S
P
D
D
V
W
K
LT
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L