@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_0984: (2015-12-19 )
MYQVAICDPIHAKGIQILEAQKDIVLHDYSKCPKKELLEKLIPMDALITRSMTPITSDFLKPLTHLKSIVRAGVGVDNIDLESCSQKGIVVMNIPTANTIAAVELTMAHLINAVRSFPCANDQIKHQRLWKREDWYGTELKNKKLGIIGFGNIGSRVGIRAKAFEMEVLAYDPYIPSSKATDLGVIYTKNFEDILQCDMITIHTPKNKETINMIGAKEIERMKKGVILINCARGGLYNEDALYEALETKKVRWLGIDVFSKEPGIHNKLLDLPNVYATPHIGANTLESQEEISKQAAQGVMESLRGSSHPHALNLPMQAFDASAKAYLNLAQKLGYFSSQIHKGVCQKIELSLCGEINQFKDALVAFTLVGVLKPVVGDKINYINAPFVAKERGIEIKVSLKESASPYKNMLSLTLNAANGAISVSGTVFEEDILKLTEIDGFHIDIEPKGKMLLFRNTDIPGVIGSVGNAFARHGINIADFRLGRNTQKEALALIIVDEEVSLEVLEELKNIPACLSVHYVVI
Atome Classification :
(23 SA)
-.........10...-----....-.20--...-..---..-.-30--.--........40..-......50.--.......60..-..-....70........80........90........-------100.......110.......120...--....130..-------.-....140.......150.......160.......170--...-....-180.......190...-.-...200.......210.......220.......230.......240.......250.......260.-..---.----..-----.270.......280.......290.......300.......310.......320.......330.......340.......350.......--360........370.......380.......390.......400.....-..410.......420.-.......430..-.-.....440.......450.......460.......470.......480.......-490-........500-........510.......520..-
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-
M
Y
Q
V
AICDPIHAK
G
-----
I
Q
I
L
-EAQ--K
D
I
-
V
L---H
D
-
Y
-S---K--C
P
K
K
E
L
L
E
K
LI
P
-
M
D
A
L
I
TRSM--TP
I
T
S
D
F
L
K
P
L
-
T
H
-
L
K
S
I
V
R
AGVGVDNI
D
L
E
SCSQK
G
I
V
V
M
NIPTANT-------
I
A
A
V
E
L
T
M
A
H
L
I
N
A
V
R
SFPCAN
D
Q
I
K
--
H
Q
R
L
WKRED-------W-YGTELKNK
K
L
G
I
I
G
FGNIGSRV
G
I
R
A
K
A
F
E
M
E
V
L
A
YD--PYI-PSSK-AT
D
L
G
V
I
Y
TK
N
F
E
D
I
L
-Q-C
D
M
I
T
I
HTPKNK
E
T
I
N
MI
G
A
K
E
I
E
R
MKK
G
V
I
L
I
NCARGGLY
N
E
D
A
L
Y
E
A
L
E
TK
K
V
R
W
L
G
I
D
V
FSKEP-GI---H----NK-----LLDLPNVYATPHIGANT
L
E
S
Q
E
E
I
S
K
Q
A
A
Q
G
V
M
E
S
LRGSSHPHALNL
P
M
Q
A
F
D
A
S
A
K
A
Y
L
N
L
A
Q
K
L
G
Y
F
S
S
Q
I
H
K
G
V
C
Q
K
I
E
L
S
LCG
E
I
N
Q
--
F
K
-
D
A
L
V
A
F
T
L
V
G
V
L
K
P
V
VGDKINYINAP
F
V
AKER
G
I
E
I
K
V
S
LKESAS
P
-
Y
K
N
M
L
S
L
T
L
NAAN
G
-
A
-
I
S
VSG
T
V
F
-
E
E
D
-
I
-
L
K
LTEID
G
F
H
I
D
IEPKG
K
M
L
L
F
RNTDIP
G
V
I
G
S
V
G
N
A
F
A
RHGIN
I
A
D
FRLGRNTQ-K-
E
-
A
L
A
L
I
I
VDE
E
--
V
S
L
E
V
L
E
E
L
KNI
P
A
C
L
S
V
H
Y
V
VI-
69
HHSearch
87.64
30%
-115
- C1 -
1YGY
1
SERA_MYCTU
A:
[4-527]
-
L
P
V
V
L
I
A
D
K
L
A
P
S
T
-----
V
A
A
L
-
G
D
Q
----
V
-
E
V
---
R
W
-
V
-
D
---
G
--
P
D
R
D
K
L
L
A
A
V
P
E
-
A
D
A
L
L
V
R
S
A
--
T
T
V
D
A
E
V
L
A
A
A
-
P
K
-
L
K
I
V
A
R
A
G
V
G
L
D
N
V
D
V
D
A
A
T
A
R
G
V
L
V
V
N
A
P
T
S
N
I
-------
H
S
A
A
E
H
A
L
A
L
L
L
A
A
S
R
Q
I
P
A
A
D
A
S
L
R
--
E
-
H
T
W
K
R
S
S
-------
F
-
S
G
T
E
I
F
G
K
T
V
G
V
V
G
L
G
R
I
G
Q
L
V
A
Q
R
I
A
A
F
G
A
Y
V
V
A
Y
D
--
P
Y
V
-
S
P
A
R
-
A
A
Q
L
G
I
E
L
L
-
S
L
D
D
L
L
A
R
-
A
D
F
I
S
V
H
L
P
K
T
P
E
T
A
G
L
I
D
K
E
A
L
A
K
T
K
P
G
V
I
I
V
N
A
A
R
G
G
L
V
D
E
A
A
L
A
D
A
I
T
G
G
H
V
R
A
A
G
L
D
V
F
A
T
E
P
-
C
T
---
D
----
S
P
-----
L
F
E
L
A
Q
V
V
V
T
P
H
L
G
A
S
T
A
E
A
Q
D
R
A
G
T
D
V
A
E
S
V
R
L
A
L
A
G
E
F
V
P
D
A
V
N
V
G
G
G
V
V
N
E
E
V
A
P
W
L
D
L
V
R
K
L
G
V
L
A
G
V
L
S
D
E
L
P
V
S
L
S
V
Q
V
R
G
E
L
A
A
EE
V
E
-
V
L
R
L
S
A
L
R
G
L
F
S
A
V
-
I
E
D
A
V
T
F
V
N
A
P
A
L
A
A
E
R
G
V
T
A
E
I
C
K
A
S
E
S
P
N
-
H
R
S
V
V
D
V
R
A
V
G
A
D
G
S
V
-
V
T
V
S
G
T
L
Y
-
G
P
Q
L
S
-
Q
K
I
V
Q
I
N
G
R
H
F
D
L
R
A
Q
G
I
N
L
I
I
H
Y
V
D
R
P
G
A
L
G
K
I
G
T
L
L
G
T
A
G
V
N
I
Q
A
A
Q
L
S
E
D
A
E
-
G
P
G
-
A
T
I
L
L
R
L
D
Q
D
--
V
P
D
D
V
R
T
A
I
A
A
A
V
D
A
Y
K
L
E
V
V
D
L
-
89
Fugue
84.92
30%
-113
- C1 -
1YGY
1
SERA_MYCTU
A:
[3-529]
S
L
P
V
V
L
I
A
D
K
L
A
P
S
T
-----
V
A
A
L
-
G
D
Q
--
V
E
V
-
R
W
---
V
D
-
G
-
P
-------
D
R
D
K
L
L
A
A
V
P
E
-
A
D
A
L
L
V
R
S
A
--
T
T
V
D
A
E
V
L
A
A
A
-
P
K
-
L
K
I
V
A
R
A
G
V
G
L
D
N
V
D
V
D
A
A
T
A
R
G
V
L
V
V
N
A
P
T
S
N
I
-------
H
S
A
A
E
H
A
L
A
L
L
L
A
A
S
R
Q
I
P
A
A
D
A
S
L
R
--
E
H
T
-
W
K
R
S
S
-------
F
-
S
G
T
E
I
F
G
K
T
V
G
V
V
G
L
G
R
I
G
Q
L
V
A
Q
R
I
A
A
F
G
A
Y
V
V
A
Y
D
--
P
Y
V
-
S
P
A
R
-
A
A
Q
L
G
I
E
L
L
S
L
D
D
L
L
A
-
R
-
A
D
F
I
S
V
H
L
P
K
T
P
E
T
A
G
L
I
D
K
E
A
L
A
K
T
K
P
G
V
I
I
V
N
A
A
R
G
G
L
V
D
E
A
A
L
A
D
A
I
T
G
G
H
V
R
A
A
G
L
D
V
F
A
T
E
P
-
C
T
---
D
----
S
P
-----
L
F
E
L
A
Q
V
V
V
T
P
H
L
G
A
S
T
A
E
A
Q
D
R
A
G
T
D
V
A
E
S
V
R
L
A
L
A
G
E
F
V
P
D
A
V
N
V
G
G
G
V
V
N
E
E
V
A
P
W
L
D
L
V
R
K
L
G
V
L
A
G
V
L
S
D
E
L
P
V
S
L
S
V
Q
V
R
G
E
L
A
A
--
E
E
V
E
V
L
R
L
S
A
L
R
G
L
F
S
A
V
I
E
D
A
V
T
F
V
N
A
P
A
L
A
A
E
R
G
V
T
A
E
I
C
K
A
S
E
S
P
N
-
H
R
S
V
V
D
V
R
A
V
G
A
D
G
S
V
-
V
T
V
S
G
T
L
Y
G
P
Q
L
-
S
-
Q
K
I
V
Q
I
N
G
R
H
F
D
L
R
A
Q
G
I
N
L
I
I
H
Y
V
D
R
P
G
A
L
G
K
I
G
T
L
L
G
T
A
G
V
N
I
Q
A
A
Q
L
S
E
D
A
E
G
P
-
G
-
A
T
I
L
L
R
L
D
Q
D
--
V
P
D
D
V
R
T
A
I
A
A
A
V
D
A
Y
K
L
E
V
V
D
L
S
21
PsiBlast_CBE
80.04
32%
-110
- C1 -
3DDN
3
SERA_MYCTU
B:
[28-509]
------------------------------------------
W
-
V
---
D
--
G
P
D
R
D
K
L
L
A
A
V
P
E
A
D
A
L
L
V
R
S
A
--
T
T
V
D
A
E
V
L
A
A
A
-
P
K
-
L
K
I
V
A
R
A
G
V
G
L
D
N
V
D
V
D
A
A
T
A
R
G
V
L
V
V
N
A
P
T
S
N
I
-------
H
S
A
A
E
H
A
L
A
L
L
L
A
A
S
R
Q
I
P
A
A
D
A
S
L
R
---
E
H
T
W
K
R
S
S
-------
F
-
S
G
T
E
I
F
G
K
T
V
G
V
V
G
L
G
R
I
G
Q
L
V
A
Q
R
I
A
A
F
G
A
Y
V
V
A
Y
D
--
P
Y
V
-
S
P
A
R
-
A
A
Q
L
G
-
I
E
L
L
S
L
D
D
L
L
A
R
-
A
D
F
I
S
V
H
L
P
K
T
P
E
T
A
G
L
I
D
K
E
A
L
A
K
T
K
P
G
V
I
I
V
N
A
A
R
G
G
L
V
D
E
A
A
L
A
D
A
I
T
G
G
H
V
R
A
A
G
L
D
V
F
A
T
E
P
-
C
T
---
D
----
S
P
-----
L
F
E
L
A
Q
V
V
V
T
P
H
L
G
A
S
T
A
E
A
Q
D
R
A
G
T
D
V
A
E
S
V
R
L
A
L
A
G
E
F
V
P
D
A
V
N
V
G
G
G
V
V
N
E
E
V
A
P
W
L
D
L
V
R
K
L
G
V
L
A
G
V
L
S
D
E
L
P
V
S
L
S
V
Q
V
R
G
E
L
A
A
--
E
E
V
E
V
L
R
L
S
A
L
R
G
L
F
S
A
V
I
E
--
V
T
F
V
N
A
P
A
L
A
A
E
R
G
V
T
A
E
I
C
-
K
A
S
E
S
P
N
H
R
S
V
V
D
V
R
A
V
G
A
D
G
-
S
V
V
T
V
S
G
T
L
Y
-
G
P
Q
-
L
S
Q
K
I
V
Q
I
N
G
R
H
F
D
L
R
A
Q
G
I
N
L
I
I
H
Y
V
D
R
P
G
A
L
G
K
I
G
T
L
L
G
T
A
G
V
N
I
Q
A
A
Q
L
S
E
D
A
E
-
G
-
P
G
A
T
I
L
L
R
L
D
Q
D
--
V
P
D
D
V
R
T
A
I
A
A
A
V
D
A
Y
K
L
E
V
V
D
L
-
2
PsiBlast_PDB
79.31
32%
-113
- C1 -
1YGY
1
SERA_MYCTU
A:
[29-510]
------------------------------------------
W
-
V
---
D
--
G
P
D
R
D
K
L
L
A
A
V
P
E
A
D
A
L
L
V
R
S
A
--
T
T
V
D
A
E
V
L
A
A
A
-
P
K
-
L
K
I
V
A
R
A
G
V
G
L
D
N
V
D
V
D
A
A
T
A
R
G
V
L
V
V
N
A
P
T
S
N
I
-------
H
S
A
A
E
H
A
L
A
L
L
L
A
A
S
R
Q
I
P
A
A
D
A
S
L
R
---
E
H
T
W
K
R
S
S
-------
F
-
S
G
T
E
I
F
G
K
T
V
G
V
V
G
L
G
R
I
G
Q
L
V
A
Q
R
I
A
A
F
G
A
Y
V
V
A
Y
D
--
P
Y
V
-
S
P
A
R
-
A
A
Q
L
G
-
I
E
L
L
S
L
D
D
L
L
A
R
-
A
D
F
I
S
V
H
L
P
K
T
P
E
T
A
G
L
I
D
K
E
A
L
A
K
T
K
P
G
V
I
I
V
N
A
A
R
G
G
L
V
D
E
A
A
L
A
D
A
I
T
G
G
H
V
R
A
A
G
L
D
V
F
A
T
E
P
-
C
T
---
D
----
S
P
-----
L
F
E
L
A
Q
V
V
V
T
P
H
L
G
A
S
T
A
E
A
Q
D
R
A
G
T
D
V
A
E
S
V
R
L
A
L
A
G
E
F
V
P
D
A
V
N
V
G
G
G
V
V
N
E
E
V
A
P
W
L
D
L
V
R
K
L
G
V
L
A
G
V
L
S
D
E
L
P
V
S
L
S
V
Q
V
R
G
E
L
A
A
--
E
E
V
E
V
L
R
L
S
A
L
R
G
L
F
S
A
V
I
E
D
A
V
T
F
V
N
A
P
A
L
A
A
E
R
G
V
T
A
E
I
C
-
K
A
S
E
S
P
N
H
R
S
V
V
D
V
R
A
V
G
A
D
G
-
S
V
V
T
V
S
G
T
L
Y
-
G
P
Q
-
L
S
Q
K
I
V
Q
I
N
G
R
H
F
D
L
R
A
Q
G
I
N
L
I
I
H
Y
V
D
R
P
G
A
L
G
K
I
G
T
L
L
G
T
A
G
V
N
I
Q
A
A
Q
L
S
E
D
A
E
-
G
-
P
G
A
T
I
L
L
R
L
D
Q
D
--
V
P
D
D
V
R
T
A
I
A
A
A
V
D
A
Y
K
L
E
V
V
D
L
-
3
PsiBlast_PDB
78.78
32%
-108
- C1 -
3DC2
2
SERA_MYCTU
A:
[29-510]
------------------------------------------
W
-
V
---
D
--
G
P
D
R
D
K
L
L
A
A
V
P
E
A
D
A
L
L
V
R
S
A
--
T
T
V
D
A
E
V
L
A
A
A
-
P
K
-
L
K
I
V
A
R
A
G
V
G
L
D
N
V
D
V
D
A
A
T
A
R
G
V
L
V
V
N
A
P
T
S
N
I
-------
H
S
A
A
E
H
A
L
A
L
L
L
A
A
S
R
Q
I
P
A
A
D
A
S
L
R
---
E
H
T
W
K
R
S
S
-------
F
-
S
G
T
E
I
F
G
K
T
V
G
V
V
G
L
G
R
I
G
Q
L
V
A
Q
R
I
A
A
F
G
A
Y
V
V
A
Y
D
--
P
Y
V
-
S
P
A
R
-
A
A
Q
L
G
-
I
E
L
L
S
L
D
D
L
L
A
R
-
A
D
F
I
S
V
H
L
P
K
T
P
E
T
A
G
L
I
D
K
E
A
L
A
K
T
K
P
G
V
I
I
V
N
A
A
R
G
G
L
V
D
E
A
A
L
A
D
A
I
T
G
G
H
V
R
A
A
G
L
D
V
F
A
T
E
P
-
C
T
---
D
----
S
P
-----
L
F
E
L
A
Q
V
V
V
T
P
H
L
G
A
S
T
A
E
A
Q
D
R
A
G
T
D
V
A
E
S
V
R
L
A
L
A
G
E
F
V
P
D
A
V
N
V
G
G
G
V
V
N
E
E
V
A
P
W
L
D
L
V
R
K
L
G
V
L
A
G
V
L
S
D
E
L
P
V
S
L
S
V
Q
V
R
G
E
L
A
A
--
E
E
V
E
V
L
R
L
S
A
L
R
G
L
F
S
A
V
I
E
D
A
V
T
F
V
N
A
P
A
L
A
A
E
R
G
V
T
A
E
I
C
-
K
A
S
E
S
P
N
H
R
S
V
V
D
V
R
A
V
G
A
D
G
-
S
V
V
T
V
S
G
T
L
Y
-
G
P
Q
-
L
S
Q
K
I
V
Q
I
N
G
R
H
F
D
L
R
A
Q
G
I
N
L
I
I
H
Y
V
D
R
P
G
A
L
G
K
I
G
T
L
L
G
T
A
G
V
N
I
Q
A
A
Q
L
S
E
D
A
E
-
G
-
P
G
A
T
I
L
L
R
L
D
Q
D
--
V
P
D
D
V
R
T
A
I
A
A
A
V
D
A
Y
K
L
E
V
V
D
L
-
1
PsiBlast_PDB
78.34
32%
-110
- C1 -
3DDN
2
SERA_MYCTU
A:
[28-509]
------------------------------------------
W
-
V
---
D
--
G
P
D
R
D
K
L
L
A
A
V
P
E
A
D
A
L
L
V
R
S
A
--
T
T
V
D
A
E
V
L
A
A
A
-
P
K
-
L
K
I
V
A
R
A
G
V
G
L
D
N
V
D
V
D
A
A
T
A
R
G
V
L
V
V
N
A
P
T
S
N
I
-------
H
S
A
A
E
H
A
L
A
L
L
L
A
A
S
R
Q
I
P
A
A
D
A
S
L
R
---
E
H
T
W
K
R
S
S
-------
F
-
S
G
T
E
I
F
G
K
T
V
G
V
V
G
L
G
R
I
G
Q
L
V
A
Q
R
I
A
A
F
G
A
Y
V
V
A
Y
D
--
P
Y
V
-
S
P
A
R
-
A
A
Q
L
G
-
I
E
L
L
S
L
D
D
L
L
A
R
-
A
D
F
I
S
V
H
L
P
K
T
P
E
T
A
G
L
I
D
K
E
A
L
A
K
T
K
P
G
V
I
I
V
N
A
A
R
G
G
L
V
D
E
A
A
L
A
D
A
I
T
G
G
H
V
R
A
A
G
L
D
V
F
A
T
E
P
-
C
T
---
D
----
S
P
-----
L
F
E
L
A
Q
V
V
V
T
P
H
L
G
A
S
T
A
E
A
Q
D
R
A
G
T
D
V
A
E
S
V
R
L
A
L
A
G
E
F
V
P
D
A
V
N
V
G
G
G
V
V
N
E
E
V
A
P
W
L
D
L
V
R
K
L
G
V
L
A
G
V
L
S
D
E
L
P
V
S
L
S
V
Q
V
R
G
E
L
A
A
--
E
E
V
E
V
L
R
L
S
A
L
R
G
L
F
S
A
V
I
E
D
A
V
T
F
V
N
A
P
A
L
A
A
E
R
G
V
T
A
E
I
C
-
K
A
S
E
S
P
N
H
R
S
V
V
D
V
R
A
V
G
A
D
G
-
S
V
V
T
V
S
G
T
L
Y
-
G
P
Q
-
L
S
Q
K
I
V
Q
I
N
G
R
H
F
D
L
R
A
Q
G
I
N
L
I
I
H
Y
V
D
R
P
G
A
L
G
K
I
G
T
L
L
G
T
A
G
V
N
I
Q
A
A
Q
L
S
E
D
A
E
-
G
-
P
G
A
T
I
L
L
R
L
D
Q
D
--
V
P
D
D
V
R
T
A
I
A
A
A
V
D
A
Y
K
L
E
V
V
D
L
-
23
PsiBlast_CBE
76.51
32%
-109
- C1 -
1YGY
2
SERA_MYCTU
B:
[29-510]
------------------------------------------
W
-
V
---
D
--
G
P
D
R
D
K
L
L
A
A
V
P
E
A
D
A
L
L
V
R
S
A
--
T
T
V
D
A
E
V
L
A
A
A
-
P
K
-
L
K
I
V
A
R
A
G
V
G
L
D
N
V
D
V
D
A
A
T
A
R
G
V
L
V
V
N
A
P
T
S
N
I
-------
H
S
A
A
E
H
A
L
A
L
L
L
A
A
S
R
Q
I
P
A
A
D
A
S
L
R
---
E
H
T
W
K
R
S
S
-------
F
-
S
G
T
E
I
F
G
K
T
V
G
V
V
G
L
G
R
I
G
Q
L
V
A
Q
R
I
A
A
F
G
A
Y
V
V
A
Y
D
--
P
Y
V
-
S
P
A
R
-
A
A
Q
L
G
-
I
E
L
L
S
L
D
D
L
L
A
R
-
A
D
F
I
S
V
H
L
P
K
T
P
E
T
A
G
L
I
D
K
E
A
L
A
K
T
K
P
G
V
I
I
V
N
A
A
R
G
G
L
V
D
E
A
A
L
A
D
A
I
T
G
G
H
V
R
A
A
G
L
D
V
F
A
T
E
P
-
C
T
---
D
----
S
P
-----
L
F
E
L
A
Q
V
V
V
T
P
H
L
G
A
S
T
A
E
A
Q
D
R
A
G
T
D
V
A
E
S
V
R
L
A
L
A
G
E
F
V
P
D
A
V
N
V
G
G
G
V
V
N
E
E
V
A
P
W
L
D
L
V
R
K
L
G
V
L
A
G
V
L
S
D
E
L
P
V
S
L
S
V
Q
V
R
G
E
L
A
A
--
E
E
V
E
V
L
R
L
S
A
L
R
G
L
F
S
A
V
I
E
D
A
V
T
F
V
N
A
P
A
L
A
A
E
R
G
V
T
A
E
I
C
-
K
A
S
E
S
P
N
H
R
S
V
V
D
V
R
A
V
G
A
D
G
-
S
V
V
T
V
S
G
T
L
Y
-
G
P
Q
-
L
S
Q
K
I
V
Q
I
N
G
R
H
F
D
L
R
A
Q
G
I
N
L
I
I
H
Y
V
D
R
P
G
A
L
G
K
I
G
T
L
L
G
T
A
G
V
N
I
Q
A
A
Q
L
S
E
D
A
E
-
G
-
P
G
A
T
I
L
L
R
L
D
Q
D
--
V
P
D
D
V
R
T
A
I
A
A
A
V
D
A
Y
K
L
E
V
V
D
L
-
22
PsiBlast_CBE
75.49
32%
-108
- C1 -
3DC2
3
SERA_MYCTU
B:
[29-510]
------------------------------------------
W
-
V
---
D
--
G
P
D
R
D
K
L
L
A
A
V
P
E
A
D
A
L
L
V
R
S
A
--
T
T
V
D
A
E
V
L
A
A
A
-
P
K
-
L
K
I
V
A
R
A
G
V
G
L
D
N
V
D
V
D
A
A
T
A
R
G
V
L
V
V
N
A
P
T
S
N
I
-------
H
S
A
A
E
H
A
L
A
L
L
L
A
A
S
R
Q
I
P
A
A
D
A
S
L
R
---
E
H
T
W
K
R
S
S
-------
F
-
S
G
T
E
I
F
G
K
T
V
G
V
V
G
L
G
R
I
G
Q
L
V
A
Q
R
I
A
A
F
G
A
Y
V
V
A
Y
D
--
P
Y
V
-
S
P
A
R
-
A
A
Q
L
G
-
I
E
L
L
S
L
D
D
L
L
A
R
-
A
D
F
I
S
V
H
L
P
K
T
P
E
T
A
G
L
I
D
K
E
A
L
A
K
T
K
P
G
V
I
I
V
N
A
A
R
G
G
L
V
D
E
A
A
L
A
D
A
I
T
G
G
H
V
R
A
A
G
L
D
V
F
A
T
E
P
-
C
T
---
D
----
S
P
-----
L
F
E
L
A
Q
V
V
V
T
P
H
L
G
A
S
T
A
E
A
Q
D
R
A
G
T
D
V
A
E
S
V
R
L
A
L
A
G
E
F
V
P
D
A
V
N
V
G
G
G
V
V
N
E
E
V
A
P
W
L
D
L
V
R
K
L
G
V
L
A
G
V
L
S
D
E
L
P
V
S
L
S
V
Q
V
R
G
E
L
A
A
--
E
E
V
E
V
L
R
L
S
A
L
R
G
L
F
S
A
V
I
E
---
T
F
V
N
A
P
A
L
A
A
E
R
G
V
T
A
E
I
C
-
K
A
S
E
S
P
N
H
R
S
V
V
D
V
R
A
V
G
A
D
G
-
S
V
V
T
V
S
G
T
L
Y
-
G
P
Q
-
L
S
Q
K
I
V
Q
I
N
G
R
H
F
D
L
R
A
Q
G
I
N
L
I
I
H
Y
V
D
R
P
G
A
L
G
K
I
G
T
L
L
G
T
A
G
V
N
I
Q
A
A
Q
L
S
E
D
A
E
-
G
-
P
G
A
T
I
L
L
R
L
D
Q
D
--
V
P
D
D
V
R
T
A
I
A
A
A
V
D
A
Y
K
L
E
V
V
D
L
-
93
Fugue
74.46
27%
-115
- C1 -
1GDH
1
DHGY_HYPME
A:
[1-320]
-
K
K
K
I
L
I
T
W
P
-----LP
E
A
A
M
A
R
A
-
R
E
S
--
Y
D
V
-
I
A
HGD---
D
-
P
---
K
--
I
T
I
D
E
M
I
E
T
A
K
S
-
V
D
A
L
L
I
T
--LN
E
K
C
R
K
E
V
I
D
R
I
-
P
E
N
I
K
C
I
S
T
Y
S
I
G
F
D
H
I
D
L
D
A
C
K
A
R
G
I
K
V
G
N
A
P
H
G
V
T
-------
V
A
T
A
E
I
A
M
L
L
L
L
G
S
A
R
R
A
G
E
G
E
K
M
I
R
T
R
S
W
P
G
W
E
P
L
E
-------
L
V
-
G
E
K
L
D
N
K
T
L
G
I
Y
G
F
G
S
I
G
Q
A
L
A
K
R
A
Q
G
F
D
M
D
I
D
Y
F
D
--
T
H
R
A
S
S
S
D
-
E
A
S
Y
Q
A
T
F
H
D
S
L
D
S
L
L
-
S
V
S
Q
F
F
S
L
N
A
P
S
T
P
E
T
R
Y
F
F
N
K
A
T
I
K
S
L
P
Q
G
A
I
V
V
N
T
A
R
G
D
L
V
D
N
E
L
V
V
A
A
L
E
A
G
R
L
A
Y
A
G
F
D
V
F
A
G
E
P
N-
I
---
N
----
E
G
-----
Y
Y
D
L
P
N
T
F
L
F
P
H
I
G
S
A
A
T
Q
A
R
E
D
M
A
H
Q
A
N
D
L
I
D
A
L
F
G
G
A
D
M
S
--
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
A
------------------------------
73
HHSearch
73.31
36%
-110
* C1 *
2G76
3
SERA_HUMAN
A:
[26-327]
-
L
R
K
V
L
I
S
D
S
L
D
P
C
C
-----
R
K
I
L
-
Q
D
G
--
G
-
L
-
Q
V
---
V
E
-
K
-
Q
---
N
--
L
S
K
E
E
L
I
A
E
L
Q
D
-
C
E
G
L
I
V
R
S
A
--
T
K
V
T
A
D
V
I
N
A
A
-
E
K
-
L
Q
V
V
G
R
A
G
T
G
V
D
N
V
D
L
E
A
A
T
R
K
G
I
L
V
M
N
T
P
N
G
N
S
-------
L
S
A
A
E
L
T
C
G
M
I
M
C
L
A
R
Q
I
P
Q
A
T
A
S
M
K
--
D
-
G
K
W
E
R
K
K
-------
F
-
M
G
T
E
L
N
G
K
T
L
G
I
L
G
L
G
R
I
G
R
E
V
A
T
R
M
Q
S
F
G
M
K
T
I
G
Y
D
--
P
I
I
-
S
P
E
V
-
S
A
S
F
G
V
Q
Q
L
-
P
L
E
E
I
W
P
L
-
C
D
F
I
T
V
H
T
P
L
L
P
S
T
T
G
L
L
N
D
N
T
F
A
Q
C
K
K
G
V
R
V
V
N
C
A
R
G
G
I
V
D
E
G
A
L
L
R
A
L
Q
S
G
Q
C
A
G
A
A
L
D
V
F
T
E
E
P
-
P
R
---
D
----
R
A
-----
L
V
D
H
E
N
V
I
S
C
P
H
L
G
A
S
T
K
E
A
Q
S
R
C
G
E
E
I
A
V
Q
F
V
D
M
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
71.88
35%
-108
- C1 -
1WWK
1
?
A:
[5-307]
---
K
V
L
V
A
A
P
L
H
E
K
A
-----
I
Q
V
L
K
D
A
G
--
L
E
V
-
I
Y
---
E
E
-
Y
---------
P
D
E
D
R
L
V
E
L
V
K
D
V
E
A
I
I
V
R
S
K
--
P
K
V
T
R
R
V
I
E
S
A
-
P
K
-
L
K
V
I
A
R
A
G
V
G
L
D
N
I
D
V
E
A
A
K
E
K
G
I
E
V
V
N
A
P
A
A
S
S
-------
R
S
V
A
E
L
A
V
G
L
M
F
S
V
A
R
K
I
A
F
A
D
R
K
M
R
---
E
G
V
W
A
K
K
E
-------
A
-
M
G
I
E
L
E
G
K
T
I
G
I
I
G
F
G
R
I
G
Y
Q
V
A
K
I
A
N
A
L
G
M
N
I
L
L
Y
D
--
P
Y
P
-
N
E
E
R
-
A
K
E
V
N
G
K
F
V
-
D
L
E
T
L
L
K
E
-
S
D
V
V
T
I
H
V
P
L
V
E
S
T
Y
H
L
I
N
E
E
R
L
K
L
M
K
K
T
A
I
L
I
N
T
S
R
G
P
V
V
D
T
N
A
L
V
K
A
L
K
E
G
W
I
A
G
A
G
L
D
V
F
E
E
E
P
L
P
K
---
D
----
H
P
-----
L
T
K
F
D
N
V
V
L
T
P
H
I
G
A
S
T
V
E
A
Q
E
R
A
G
V
E
V
A
E
K
V
V
K
I
L
K
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
87
HHSearch
71.77
30%
-114
- C1 -
2CUK
-
?
A:
[1-310]
--
M
R
V
L
V
T
R
T
L
P
G
K
A
-----
L
D
R
L
-
R
E
R
--
G
-
L
-
E
V
---
E
V
-
H
-
R
---
G
LF
L
P
K
A
E
L
L
K
R
V
E
G
-
A
V
G
L
I
P
T
V
E
--
D
R
I
D
A
E
V
M
D
R
A
-
K
G
-
L
K
V
I
A
C
Y
S
V
G
V
D
H
V
D
L
E
A
A
R
E
R
G
I
R
V
T
H
T
P
G
V
L
T
-------
E
A
T
A
D
L
T
L
A
L
L
L
A
V
A
R
R
V
V
E
G
A
A
Y
A
R
--
D
-
G
L
W
K
A
W
H
PEL----
L
-
L
G
L
D
L
Q
G
L
T
L
G
L
V
G
M
G
R
I
G
Q
A
V
A
K
R
A
L
A
F
G
M
R
V
V
Y
H
A
--
R
T
P
-
K
P
L
P
------
Y
P
F
L
-
S
L
E
E
L
L
K
E
-
A
D
V
V
S
L
H
T
P
L
T
P
E
T
H
R
L
L
N
R
E
R
L
F
A
M
K
R
G
A
I
L
L
N
T
A
R
G
A
L
V
D
T
E
A
L
V
E
A
L
R
-
G
H
L
F
G
A
G
L
D
V
T
D
P
E
P
-
L
P
P--
G
----
H
P
-----
L
Y
A
L
P
N
A
V
I
T
P
H
I
G
S
A
G
R
T
T
R
E
R
M
A
E
V
A
V
E
N
L
L
A
V
L
E
G
R
E
P
P
N
P
V
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
80
HHSearch
71.45
35%
-105
- C1 -
1WWK
1
?
A:
[4-307]
--
M
K
V
L
V
A
A
P
L
H
E
K
A
-----
I
Q
V
L
-
K
D
A
--
G
-
L
-
E
V
---
I
Y
-
E
-
E
---
Y
--
P
D
E
D
R
L
V
E
L
V
K
D
-
V
E
A
I
I
V
R
S
K
--
P
K
V
T
R
R
V
I
E
S
A
-
P
K
-
L
K
V
I
A
R
A
G
V
G
L
D
N
I
D
V
E
A
A
K
E
K
G
I
E
V
V
N
A
P
A
A
S
S
-------
R
S
V
A
E
L
A
V
G
L
M
F
S
V
A
R
K
I
A
F
A
D
R
K
M
R
--
E
-
G
V
W
A
K
K
E
-------
A
-
M
G
I
E
L
E
G
K
T
I
G
I
I
G
F
G
R
I
G
Y
Q
V
A
K
I
A
N
A
L
G
M
N
I
L
L
Y
D
--
P
Y
P
-
N
E
E
R
-
A
K
E
V
N
G
K
F
V
-
D
L
E
T
L
L
K
E
-
S
D
V
V
T
I
H
V
P
L
V
E
S
T
Y
H
L
I
N
E
E
R
L
K
L
M
K
K
T
A
I
L
I
N
T
S
R
G
P
V
V
D
T
N
A
L
V
K
A
L
K
E
G
W
I
A
G
A
G
L
D
V
F
E
E
E
P
-
L
P
K--
D
----
H
P
-----
L
T
K
F
D
N
V
V
L
T
P
H
I
G
A
S
T
V
E
A
Q
E
R
A
G
V
E
V
A
E
K
V
V
K
I
L
K
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
83
HHSearch
70.64
27%
-110
- C1 -
1GDH
1
DHGY_HYPME
A:
[1-318]
-
K
K
K
I
L
I
T
W
P
L
P
E
A
A
-----
M
A
R
A
-
R
E
S
----
Y
-
D
V
---
I
A
-
H
-
G
DDP
K
--
I
T
I
D
E
M
I
E
T
A
K
S
-
V
D
A
L
L
I
T
L
N
--
E
K
C
R
K
E
V
I
D
R
I
P
E
N
-
I
K
C
I
S
T
Y
S
I
G
F
D
H
I
D
L
D
A
C
K
A
R
G
I
K
V
G
N
A
P
H
G
V
T
-------
V
A
T
A
E
I
A
M
L
L
L
L
G
S
A
R
R
A
G
E
G
E
K
M
I
R
--
T
-
R
S
W
P
G
W
E
PLE----
L
-
V
G
E
K
L
D
N
K
T
L
G
I
Y
G
F
G
S
I
G
Q
A
L
A
K
R
A
Q
G
F
D
M
D
I
D
Y
F
D
--
T
H
R
-
A
S
S
S
D
E
A
S
Y
Q
A
T
F
H
D
S
L
D
S
L
L
S
V
-
S
Q
F
F
S
L
N
A
P
S
T
P
E
T
R
Y
F
F
N
K
A
T
I
K
S
L
P
Q
G
A
I
V
V
N
T
A
R
G
D
L
V
D
N
E
L
V
V
A
A
L
E
A
G
R
L
A
Y
A
G
F
D
V
F
A
G
E
P
-
N
I
---
N
----
E
G
-----
Y
Y
D
L
P
N
T
F
L
F
P
H
I
G
S
A
A
T
Q
A
R
E
D
M
A
H
Q
A
N
D
L
I
D
A
L
F
G
G
A
D
M
S
Y
A
L
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
70
HHSearch
68.57
30%
-106
- C1 -
1SC6
1
SERA_ECOLI
A:
[4-404]
-
K
I
K
F
L
L
V
E
G
V
H
Q
K
A
-----
L
E
S
L
-
R
A
A
--
G
-
Y
-
T
N
---
I
E
-
F
H
K
G
--
A
--
L
D
D
E
Q
L
K
E
S
I
R
D
-
A
H
F
I
G
L
R
S
R
--
T
H
L
T
E
D
V
I
N
A
A
-
E
K
-
L
V
A
I
G
A
F
A
I
G
T
N
Q
V
D
L
D
A
A
A
K
R
G
I
P
V
F
N
A
P
F
S
N
T
-------
R
S
V
A
E
L
V
I
G
E
L
L
L
L
L
R
G
V
P
E
A
N
A
K
A
H
--
R
-
G
V
G
N
-------------
S
F
E
A
R
G
K
K
L
G
I
I
G
Y
G
H
I
G
T
Q
L
G
I
L
A
E
S
L
G
M
Y
V
Y
F
Y
D
--
I
E
N
-
K
L
P
L
----
G
N
A
T
Q
V
Q
H
L
S
D
L
L
N
M
-
S
D
V
V
S
L
H
V
P
E
N
P
S
T
K
N
M
M
G
A
K
E
I
S
L
M
K
P
G
S
L
L
I
N
A
S
R
G
T
V
V
D
I
P
A
L
A
D
A
L
A
S
K
H
L
A
G
A
A
I
D
V
--------DPF
T
----
S
P
-----
L
A
E
F
D
N
V
L
L
T
P
H
I
G
G
S
T
Q
E
A
Q
E
N
I
G
L
E
V
A
G
K
L
I
K
Y
S
D
N
G
S
T
L
S
A
V
N
F
P
E
V
S
L
P
---------------------------------------------------------------------------------------
L
------------------------------------------------
H
G
G
R
R
L
M
H
I
H
E
N
R
P
G
V
L
T
A
L
N
K
I
F
A
E
Q
G
V
N
I
A
A
Q
Y
L
--
Q
T
S
-
A
Q
M
-
G
Y
V
V
I
D
I
E
A
D
E
D
V
A
E
K
A
L
Q
A
M
K
A
I
P
G
T
I
R
A
R
L
L
Y
--
76
HHSearch
67.55
31%
-109
- C1 -
2DBQ
8
GYAR_PYRHO
A:
[2-327]
-
K
P
K
V
F
I
T
R
E
I
P
E
V
G
-----
I
K
M
L
-
E
D
E
----
F
-
E
V
---
E
V
-
W
-
G
D
EK
E
--
I
P
R
E
I
L
L
K
K
V
K
E
-
V
D
A
L
V
T
M
L
S
--
E
R
I
D
K
E
V
F
E
N
A
-
P
K
-
L
R
I
V
A
N
Y
A
V
G
Y
D
N
I
D
I
E
E
A
T
K
R
G
I
Y
V
T
N
T
P
D
V
L
T
-------
D
A
T
A
D
L
A
F
A
L
L
L
A
T
A
R
H
V
V
K
G
D
R
F
V
R
--
S
-
G
E
W
K
K
R
G
VAWHPKW
F
-
L
G
Y
D
V
Y
G
K
T
I
G
I
I
G
L
G
R
I
G
Q
A
I
A
K
R
A
K
G
F
N
M
R
I
L
Y
Y
S
--
R
T
R
-
K
E
E
V
-
E
R
E
L
N
A
E
F
K
-
P
L
E
D
L
L
R
E
-
S
D
F
V
V
L
A
V
P
L
T
R
E
T
Y
H
L
I
N
E
E
R
L
K
L
M
K
K
T
A
I
L
I
N
I
A
R
G
K
V
V
D
T
N
A
L
V
K
A
L
K
E
G
W
I
A
G
A
G
L
D
V
F
E
E
E
P
-
Y
Y
---
N
----
E
E
-----
L
F
K
L
D
N
V
V
L
T
P
H
I
G
S
A
S
F
G
A
R
E
G
M
A
E
L
V
A
K
N
L
I
A
F
K
R
G
E
I
P
P
T
L
V
N
R
E
V
I
K
I
R
K
P
G
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
67.36
33%
-102
- C1 -
2P9E
7
SERA_ECOLI
A:
[15-328]
------
L
V
E
G
V
H
Q
K
A
-----
L
E
S
L
-
R
A
A
GY
T
N
I
-
E
F
---
H
K
---
G
---
A
--
L
D
D
E
Q
L
K
E
S
I
R
D
-
A
H
F
I
G
L
R
S
R
--
T
H
L
T
E
D
V
I
N
A
A
-
E
K
-
L
V
A
I
G
A
F
A
I
G
T
N
Q
V
D
L
D
A
A
A
K
R
G
I
P
V
F
N
A
P
F
S
N
T
-------
R
S
V
A
E
L
V
I
G
E
L
L
L
L
L
R
G
V
P
E
A
N
A
K
-
A
--
H
R
G
V
W
N
K
L
A
-------
A
-
G
S
F
E
A
R
G
K
K
L
G
I
I
G
Y
G
H
I
G
T
Q
L
G
I
L
A
E
S
L
G
M
Y
V
Y
F
Y
D
I
E
N
K
L
-
P
L
G
N
-
A
T
Q
V
-----
Q
H
L
S
D
L
L
-
N
M
S
D
V
V
S
L
H
V
P
E
N
P
S
T
K
N
M
M
G
A
K
E
I
S
L
M
K
P
G
S
L
L
I
N
A
S
R
G
T
V
V
D
I
P
A
L
A
D
A
L
A
S
K
H
L
A
G
A
A
I
D
V
F
P
T
E
P
-
A
T
---
N
----
S
D
P
F
T
S
P
L
A
E
F
D
N
V
L
L
T
P
H
I
G
G
S
T
Q
E
A
Q
E
N
I
G
L
E
V
A
G
K
L
I
K
Y
S
D
N
G
S
T
L
S
A
V
N
F
P
E
V
S
L
P
L
H
V
G
R
R
L
M
H
I
H
E
N
R
P
G
V
L
T
A
L
N
K
I
F
A
E
Q
G
V
N
I
A
A
Q
Y
L
Q
--
T
S
-
A
Q
M
G
Y
V
V
I
D
I
E
A
D
E
D
V
A
E
K
A
L
Q
A
M
K
A
I
P
G
T
I
R
A
R
L
L
Y
------------------------------------------------------------------------------------------------------------------------------------------
55
PsiBlast_CBE
66.91
31%
-105
- C1 -
2DBR
3
GYAR_PYRHO
B:
[4-322]
---
K
V
F
I
T
R
E
I
P
E
V
G
-----
I
K
M
L
-
E
D
E
--
F
E
V
E
V
W
---
G
D
-
E
-
K
---
E
--
I
P
R
E
I
L
L
K
K
V
K
E
-
V
D
A
L
V
T
M
L
S
--
E
R
I
D
K
E
V
F
E
N
A
-
P
K
-
L
R
I
V
A
N
Y
A
V
G
Y
D
N
I
D
I
E
E
A
T
K
R
G
I
Y
V
T
N
T
P
D
V
L
T
DATADLA
F
A
L
L
L
A
T
A
R
H
V
V
K
G
D
R
-
F
V
R
S
G
E
W
K
K
--
R
G
V
A
W
H
P
K
W
-------
F
-
L
G
Y
D
V
Y
G
K
T
I
G
I
I
G
L
G
R
I
G
Q
A
I
A
K
R
A
K
G
F
N
M
R
I
L
Y
Y
S
--
R
T
R
-
K
E
E
V
-
E
R
E
L
N
A
E
F
-
K
P
L
E
D
L
L
R
E
-
S
D
F
V
V
L
A
V
P
L
T
R
E
T
Y
H
L
I
N
E
E
R
L
K
L
M
K
K
T
A
I
L
I
N
I
A
R
G
K
V
V
D
T
N
A
L
V
K
A
L
K
E
G
W
I
A
G
A
G
L
D
V
F
E
E
E
P
-
Y
Y
---
N
----
E
E
-----
L
F
K
L
D
N
V
V
L
T
P
H
I
G
S
A
S
F
G
A
R
E
G
M
A
E
L
V
A
K
N
L
I
A
F
K
R
G
E
I
P
P
T
L
V
N
R
E
V
I
K
I
R
K
P
G
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
66.18
33%
-105
- C1 -
2P9E
7
SERA_ECOLI
C:
[15-328]
------
L
V
E
G
V
H
Q
K
A
-----
L
E
S
L
-
R
A
A
GY
T
N
I
-
E
F
---
H
K
---
G
---
A
--
L
D
D
E
Q
L
K
E
S
I
R
D
-
A
H
F
I
G
L
R
S
R
--
T
H
L
T
E
D
V
I
N
A
A
-
E
K
-
L
V
A
I
G
A
F
A
I
G
T
N
Q
V
D
L
D
A
A
A
K
R
G
I
P
V
F
N
A
P
F
S
N
T
-------
R
S
V
A
E
L
V
I
G
E
L
L
L
L
L
R
G
V
P
E
A
N
A
K
-
A
--
H
R
G
V
W
N
K
L
A
-------
A
-
G
S
F
E
A
R
G
K
K
L
G
I
I
G
Y
G
H
I
G
T
Q
L
G
I
L
A
E
S
L
G
M
Y
V
Y
F
Y
D
IE
N
K
L
-
P
L
G
N
-
A
T
Q
V
-----
Q
H
L
S
D
L
L
-
N
M
S
D
V
V
S
L
H
V
P
E
N
P
S
T
K
N
M
M
G
A
K
E
I
S
L
M
K
P
G
S
L
L
I
N
A
S
R
G
T
V
V
D
I
P
A
L
A
D
A
L
A
S
K
H
L
A
G
A
A
I
D
V
F
P
T
E
P
-
A
T
---
N
----
S
D
PFTSP
L
A
E
F
D
N
V
L
L
T
P
H
I
G
G
S
T
Q
E
A
Q
E
N
I
G
L
E
V
A
G
K
L
I
K
Y
S
D
N
G
S
T
L
S
A
V
N
F
P
E
V
S
L
P
L
H
V
G
R
R
L
M
H
I
H
E
N
R
P
G
V
L
T
A
L
N
K
I
F
A
E
Q
G
V
N
I
A
A
Q
Y
L
Q
--
T
S
-
A
Q
M
G
Y
V
V
I
D
I
E
A
D
E
D
V
A
E
K
A
L
Q
A
M
K
A
I
P
G
T
I
R
A
R
L
L
Y
------------------------------------------------------------------------------------------------------------------------------------------
85
HHSearch
65.98
28%
-101
- C1 -
3K5P
4
?
A:
[15-415]
-
R
I
N
V
L
L
L
E
G
I
S
Q
T
A
-----
V
E
Y
F
-
K
S
S
--
G
-
Y
-
T
N
---
V
T
H
L
-
P
K
--
A
--
L
D
K
A
D
L
I
K
A
I
S
S
-
A
H
I
I
G
I
R
S
R
--
T
Q
L
T
E
E
I
F
A
A
A
-
N
R
-
L
I
A
V
G
C
F
S
V
G
T
N
Q
V
E
L
K
A
A
R
K
R
G
I
P
V
F
N
A
P
F
S
N
T
-------
R
S
V
A
E
L
V
I
G
E
I
I
M
L
M
R
R
I
F
P
R
S
V
S
A
H
--
A
-
G
G
W
E
K
T
A
-------
I
-
G
S
R
E
V
R
G
K
T
L
G
I
V
G
Y
G
N
I
G
S
Q
V
G
N
L
A
E
S
L
G
M
T
V
R
Y
Y
D
--
T
S
D
-
K
L
Q
Y
----
G
N
V
K
P
A
A
S
L
D
E
L
L
K
T
-
S
D
V
V
S
L
H
V
P
-----
S
K
L
I
T
E
A
K
L
R
K
M
K
K
G
A
F
L
I
N
N
A
R
G
S
D
V
D
L
E
A
L
A
K
V
L
Q
E
G
H
L
A
G
A
A
I
D
V
F
P
V
E
P
-
A
S
N--
G
E
R
F
S
T
P
-----
L
Q
G
L
E
N
V
I
L
T
P
H
I
G
G
S
T
E
E
A
Q
E
R
I
G
T
E
V
T
R
K
L
V
E
Y
S
D
V
G
S
T
V
G
A
V
N
F
P
Q
V
Q
L
P
------------------
P
R
-
P
T
-------------------------------------------------------------------------------------------------------------------
G
T
R
F
M
H
V
H
E
N
R
P
G
I
L
N
S
L
M
N
V
F
S
H
H
H
I
N
I
A
S
Q
F
L
--
Q
T
D
-
G
E
V
-
G
Y
L
V
M
E
A
D
G
V
G
E
A
S
D
A
V
L
Q
E
I
R
E
I
P
G
T
I
R
A
R
L
L
Y
--
25
PsiBlast_CBE
65.56
35%
-110
- C1 -
1WWK
1
?
B:
[5-305]
---
K
V
L
V
A
A
P
L
H
E
K
A
-----
I
Q
V
L
K
D
A
G
--
L
E
V
-
I
Y
---
E
E
-
Y
---------
P
D
E
D
R
L
V
E
L
V
K
D
V
E
A
I
I
V
R
S
K
--
P
K
V
T
R
R
V
I
E
S
A
-
P
K
-
L
K
V
I
A
R
A
G
V
G
L
D
N
I
D
V
E
A
A
K
E
K
G
I
E
V
V
N
A
P
A
A
S
S
-------
R
S
V
A
E
L
A
V
G
L
M
F
S
V
A
R
K
I
A
F
A
D
R
K
M
R
---
E
G
V
W
A
K
K
E
-------
A
-
M
G
I
E
L
E
G
K
T
I
G
I
I
G
F
G
R
I
G
Y
Q
V
A
K
I
A
N
A
L
G
M
N
I
L
L
Y
D
--
P
Y
P
-
N
E
E
R
-
A
K
E
V
N
G
K
F
V
-
D
L
E
T
L
L
K
E
-
S
D
V
V
T
I
H
V
P
L
V
E
S
T
Y
H
L
I
N
E
E
R
L
K
L
M
K
K
T
A
I
L
I
N
T
S
R
G
P
V
V
D
T
N
A
L
V
K
A
L
K
E
G
W
I
A
G
A
G
L
D
V
F
E
E
E
P
L
P
K
---
D
----
H
P
-----
L
T
K
F
D
N
V
V
L
T
P
H
I
G
A
S
T
V
E
A
Q
E
R
A
G
V
E
V
A
E
K
V
V
K
I
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
60.27
36%
-98
- C1 -
2G76
3
SERA_HUMAN
B:
[47-327]
--------------
G
-----
L
Q
V
V
-
E
K
Q
--
N
--------------------
L
S
K
E
E
L
I
A
E
L
Q
D
-
C
E
G
L
I
V
R
S
A
--
T
K
V
T
A
D
V
I
N
A
A
-
E
K
-
L
Q
V
V
G
R
A
G
T
G
V
D
N
V
D
L
E
A
A
T
R
K
G
I
L
V
M
N
T
P
N
G
N
S
-------
L
S
A
A
E
L
T
C
G
M
I
M
C
L
A
R
Q
I
P
Q
A
T
A
S
M
K
--
D
G
K
-
W
E
R
K
K
-------
F
-
M
G
T
E
L
N
G
K
T
L
G
I
L
G
L
G
R
I
G
R
E
V
A
T
R
M
Q
S
F
G
M
K
T
I
G
Y
D
--
P
I
I
-
S
P
E
V
-
S
A
S
F
G
V
Q
Q
L
P
L
E
E
I
W
P
-
L
-
C
D
F
I
T
V
H
T
P
L
L
P
S
T
T
G
L
L
N
D
N
T
F
A
Q
C
K
K
G
V
R
V
V
N
C
A
R
G
G
I
V
D
E
G
A
L
L
R
A
L
Q
S
G
Q
C
A
G
A
A
L
D
V
F
T
E
E
P
-
P
R
---
D
----
R
A
-----
L
V
D
H
E
N
V
I
S
C
P
H
L
G
A
S
T
K
E
A
Q
S
R
C
G
E
E
I
A
V
Q
F
V
D
M
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
59.37
36%
-98
- C1 -
2G76
3
SERA_HUMAN
A:
[47-327]
--------------
G
-----
L
Q
V
V
-
E
K
Q
--
N
--------------------
L
S
K
E
E
L
I
A
E
L
Q
D
-
C
E
G
L
I
V
R
S
A
--
T
K
V
T
A
D
V
I
N
A
A
-
E
K
-
L
Q
V
V
G
R
A
G
T
G
V
D
N
V
D
L
E
A
A
T
R
K
G
I
L
V
M
N
T
P
N
G
N
S
-------
L
S
A
A
E
L
T
C
G
M
I
M
C
L
A
R
Q
I
P
Q
A
T
A
S
M
K
--
D
G
K
-
W
E
R
K
K
-------
F
-
M
G
T
E
L
N
G
K
T
L
G
I
L
G
L
G
R
I
G
R
E
V
A
T
R
M
Q
S
F
G
M
K
T
I
G
Y
D
--
P
I
I
-
S
P
E
V
-
S
A
S
F
G
V
Q
Q
L
P
L
E
E
I
W
P
-
L
-
C
D
F
I
T
V
H
T
P
L
L
P
S
T
T
G
L
L
N
D
N
T
F
A
Q
C
K
K
G
V
R
V
V
N
C
A
R
G
G
I
V
D
E
G
A
L
L
R
A
L
Q
S
G
Q
C
A
G
A
A
L
D
V
F
T
E
E
P
-
P
R
---
D
----
R
A
-----
L
V
D
H
E
N
V
I
S
C
P
H
L
G
A
S
T
K
E
A
Q
S
R
C
G
E
E
I
A
V
Q
F
V
D
M
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------