@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_0987: (2015-12-19 )
MLETYALKSGAVFISDAHFLPKSPHLIHTLKELLSAKPPQVFFMGDIFHVLVGYLPLDKEQQKIIDLIHALSEISQVFYFEGNHDFSMRFVFNSKVMVFERQNQPALFQYDNKRFLLAHGDLFITKAYEFYITQLTSTWARFFLTFLNLLSFKTLYPFLKKRIYQKPVRLWELEPKELKAFIEKRLKAYQNYIKDLNIDSIDGIIEGHFHLKSGTKIHSSVPIYCPLPSFYYEQSLFKVSSSLLEPSQNKDA
Atome Classification :
(20 SA)
------------.........10-........-.------20..----------.----------.------.----------...------30-....--------.--.------..-.40---.........50.--.....---------.-.60....-....70--------..--...-.-------.-----..80....--------..---..90-...---------.---.....100.--------..--.-------...110.....--------..-120...-------.-...-130----.----------..-.....140.--...--.-----------..150------.......160..--.....170..-......180----.-------.....-------------------------.190....-.-..200...-.-.-----------------..210.....-----.---.220.-----.-----.....-----------------------230.---------.----......240....-..-.-250---------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
------------M
L
E
T
Y
ALKS
G
--
A
V
F
I
SDAH-F------LPKS----------
P
----------
H
------
L
----------
I
H
T
------
L
--
K
E
L
L--------S--A------KP-
P
Q
----
V
F
F
M
G
D
I
F
H
V
L
V
--
G
YLPL---------
D
-
K
E
Q
Q
K
I
I
-
D
L
I
H
A
---------
L
S
--
E
I
S
-
Q
-------
V
-----
F
Y
FEGNH
D
--------
F
S
---
M
R
F
--
V
FN---------
S
---
K
V
M
V
F
ERQN--------Q
P
--
A
-------
L
F
Q
YDN
K
R
F
L
L
--------AH-G
D
L
F
I
T
-------
K
-
A
Y
E
-
F
-
Y
----
I
----------
T
Q
-
L
T
S
T
W
A
R
F
F
--
L
T
F
--
L
-----------
N
L
L
S
F
------
K
T
L
Y
P
F
L
K
K
R
I
Y
--QKP
V
R
L-WEL-
E
P
K
E
L
K
A
F
I
----
E
-------
K
R
L
K
A
-------------------------
Y
Q
N
Y
I
K
DL-N-ID
S
I
D
G
I
I
-
E
-
G
-----------------
H
F
H
LKSG
T
K
I-----H---SSV
P
I
-----
Y
-----CPL
P
S
-----------------------
F
Y
-
Y
---------
E
----
Q
S
L
F
K
V
S
S
S
LLEP-SQ-N-KDA---------------------------------------------------
23
HHSearch
79.05
17%
-117
- C2 -
1SU1
3
YFCE_ECOLI
A:
[25-190]
-------------------
M
M
K
--
L
M
F
A
S
D
I
H
-
G
------
S
L
P
A
----------------------------
T
----------
E
R
V
------
L
--
E
L
F
A
--------
Q
--
S
------
G
A
-
Q
W
----
L
V
I
L
G
D
V
L
N
H
G
P
--
R
N
A
L
P
---------
E
G
Y
A
P
A
K
V
V
-
E
R
L
N
E
---------
V
----
A
H
-
K
-------
V
-----
I
A
V
R
G
N
C
D
--------
S
E
---
V
D
Q
--
M
L
L
-------------
H
---
F
P
I
T
A
--------
P
W
--
Q
-------
Q
V
L
L
E
K
Q
R
L
F
L
--------
T
H
-
G
H
L
F
G
P
-------
E
------------------------------------------------------------------------------------------------
N
-
L
--------------
P
A
L
-------------------------
N
------------
Q
N
D
V
L
V
-
Y
-
G
-----------------
H
T
H
L
P
V
A
E
Q
R
-----
G
-----
E
I
F
-----
H
-----
F
N
P
G
S
-----------------------
V
S
-
I
PKGGN----
P
----
A
S
Y
G
M
L
D
N
D
V
L
S
V
-
I
A
-
L
-
N
D
Q
---------------------------------------------------
29
HHSearch
74.97
13%
-104
* C2 *
3IB7
7
CPDA_MYCTU
A:
[22-240]
----------------
P
R
P
D
Y
V
--
L
L
H
I
S
D
T
H
-
L
------
I
G
G
D
RRLYGAVD
A
D
D
----------
R
------
L
----------
G
E
L
------
L
--
E
Q
L
N
--------
Q
S
G
L
------
R
P
-
D
A
----
I
V
F
T
G
D
L
A
D
K
G
E
----
P
-------------
A
A
Y
R
K
L
R
-
G
L
V
E
P
---------
F
A
A
Q
L
G
A
-
E
-------
L
-----
V
W
V
M
G
N
H
D
--------
D
R
---
A
E
L
R
K
F
L
L
-------------
D
E
-
A
P
S
M
A
P
--------
L
D
--
R
-------
V
C
M
I
D
G
L
R
I
I
V
--------
L
D
-
T
S
V
P
G
H
H
H
G
E
I
R
A
S
-
Q
L
G
-
W
-
L
----
A
----------
E
E
-
L
A
T
P
A
P
D
G
T
I
L
A
L
H
--
H
-----------
P
P
I
P
S
------
V
--
L
D
----
M
A
V
---
T
---------
V
E
L
R
D
Q
A
A
L
----
G
-------
R
V
L
R
G
-------------------------
T
------------
D
V
R
A
I
L
-
A
-
G
-----------------
H
L
H
Y
S
T
N
A
T
F
-----
V
-----
G
I
P
-----
V
-----
S
V
A
S
A
-----------------------
T
C
-
Y
---------
T
----
Q
D
L
T
V
A
A
G
G
T
R
G
R
-
D
G
-
A
-
Q
G
C
---------------------------------------------------
33
HHSearch
74.33
13%
-93
- C2 -
3E0J
-
DPOD2_HUMAN
A:
[191-447]
-----------------
D
T
D
R
F
--
V
L
L
V
S
G
L
G
-
L
------
G
G
G
G
----------
G
E
S
L
L
G
T
Q
---
L
------
L
----------
V
D
V
------
V
--
T
G
Q
L
GD
E
G
E
Q
C
S
A
--
A
------
H
V
-
S
R
----
V
I
L
A
G
N
L
L
S
H
---------LT
K
K
T
Q
A
A
S
V
-
E
A
V
K
M
L
D
-
E
I
L
L
Q
---------
L
S
--
A
S
V
-
P
-------
V
-----
D
V
M
P
G
E
F
D
--------
P
T
---
N
Y
---
T
L
P
QQPLHPCMF
P
LAT
A
Y
S
T
L
Q
L
V
T
--------
N
P
--
Y
-------
Q
A
T
I
D
G
V
R
F
L
G
--------
T
S
-
G
Q
N
V
S
D
-------
I
F
R
Y
S
-
S
-
M
----
E
-------------
D
H
L
E
I
L
E
W
T
--
L
R
V
-------------------------
R
H
I
S
P
----
T
A
------
P
D
T
------------
Y
K
----
T
-------
D
P
F
I
F
-------------------------
P
-----------
E
C
P
H
V
Y
F
-
C
-
G
-----------------
N
T
P
S
F
G
S
K
I
I
-----
R
G
PE
D
Q
T
V
L
-----
L
-----
V
T
V
P
D
-----------------------
F
S
-
A
---------
T
----
Q
T
A
C
L
V
N
L
R
S
L
A
C
-
Q
P
-
I
-
S
F
S
---------------------------------------------------
47
Fugue
73.04
14%
-97
- C2 -
2DXN
2
?
A:
[1-271]
--------------------
M
L
--
L
A
H
I
S
D
T
H
-
F
------
R
S
R
G
----------
E
----------
K
LYGFID
V
----------
N
A
A
------
N
--
A
D
V
V
--------
S
--
Q
L
N
A
LRE
R
P
-
D
A
----
V
V
V
S
G
D
I
V
N
-------------------
C
-
G
R
P
E
E
Y
Q
-
V
A
R
Q
I
---------
L
G
--
S
L
N
Y
P
-------
L
-----
Y
L
I
P
G
N
H
D
D
K
------
A
L
---
F
L
E
--
Y
L
Q
---------
P
---
L
C
P
Q
L
G
S
D
A
--------
N
N
--
M
-------
R
C
A
V
D
D
F
A
T
R
L
--------
L
F
-
I
D
S
S
R
A
-------
G
-
T
S
K
-------------------
G
W
-
L
T
D
E
T
I
S
W
L
--
E
A
Q
--
L
-----------
F
E
G
G
D
------
K
P
A
T
I
F
M
H
H
P
P
L
--
P
L
G
N
A
Q
-
M
D
P
-
I
A
C
E
N
G
H
R
L
----
L
-------
A
L
V
E
R
-------------------------
F
P
S
-----------
L
T
R
I
F
-
C
-
G
-----------------
H
N
H
S
L
T
M
T
Q
Y
-----
R
---
Q
A
L
I
S
-----
T
-----
L
P
G
T
V
H
Q
V
P
Y
C
HEDTDPYYDL
S
P
A
S
C
L
M
H
R
-
Q
---------
V
----
G
E
Q
W
V
S
Y
Q
H
S
L
A
H
-
Y
A
-
G
-
P
W
L
Y
D
ENISCPT------------------------------------------
41
Fugue
73.04
12%
-75
- C2 -
2HY1
3
CPDA_MYCTU
A:
[12-267]
----------------
P
R
P
D
Y
V
--
L
L
H
I
S
D
T
H
-
L
------
I
D
A
D
----------
D
----------
R
------
L
----------
G
E
L
------
L
--
E
Q
L
N
--------
Q
--
S
GL----
R
P
-
D
A
----
I
V
F
T
G
D
L
A
D
K
----
G
E
P
A
A
---------
Y
-
R
K
L
R
G
L
V
-
E
P
F
A
A
---------
Q
L
--
G
A
--
E
-------
L
-----
V
W
V
M
G
N
H
D
-------------
D
R
A
--
E
L
R
---------
K
---
F
L
L
D
E
A
P
S
M
--------
A
P
--
L
-------
D
R
V
C
M
I
D
G
L
R
I
--------
I
V
-
L
D
T
S
V
P
-------
G
-
H
H
H
-------------------
G
E
-
I
R
A
S
Q
L
G
W
L
--
A
E
E
--
L
-----------
A
T
P
A
P
------
D
G
T
I
L
A
L
H
H
P
P
I
--
P
S
V
L
D
M
-
A
V
---------------
T
-------
V
E
L
R
D
-------------------------
Q
A
A
L
G
R
V
L
-
R
-
G
T
D
V
R
A
I
L
-
A
-
G
-----------------
H
L
H
Y
S
T
N
A
T
F
-----
V
---
G
I
P
V
S
-----
V
-----
A
S
A
T
C
-----------------------
G
C
-
N
---------
L
----
V
H
V
Y
P
D
T
V
V
H
S
V
I
-
P
----------------------------------------------------------
43
Fugue
72.07
16%
-68
- C2 -
1G5B
4
PP_LAMBD
A:
[1-219]
----------MR
Y
Y
E
K
I
D
G
S
K
Y
R
N
I
W
V
V
G
D
L
H
----------
G
C
----------
Y
----------
T
------
N
----------
L
M
N
------
K
--
L
D
T
I
--------
G
--
F
------
D
N
-
K
K
D
L
--
L
I
S
V
G
D
----
L
V
--
D
R
G
A
-------------
E
N
V
E
C
L
-
E
L
I
T
F
---------------
P
-
W
-------
F
-----
R
A
V
R
G
N
H
E
--------
Q
M
---
M
I
D
--
G
L
S
---------
E
---
R
G
N
V
N
H
W
L
L
--------
N
G
--
G
-------
G
W
F
F
N
L
D
Y
D
K
E
--------
I
L
-
A
K
A
L
A
H
-------
K
-
A
D
E
-
L
-
P
----
L
--------------------------
I
--
I
-----------
E
L
V
S
K
------
D
K
K
Y
V
I
C
H
A
D
Y
P
--
F
D
E
Y
E
F
-
G
K
P
-
V
D
H
Q
Q
V
I
W
N
----
R
-------
E
R
I
S
N
-------------------------
S
Q
N
G
I
V
K
--
E
-
I
K
G
A
D
T
F
I
-
F
-
G
-----------------
H
T
P
A
V
K
P
L
K
F
-----
A
---
N
Q
M
Y
I
-----
D
-----
T
G
------------------------------------------------
A
V
F
C
G
N
L
T
L
-
I
Q
-
V
-
Q
G
A
---------------------------------------------------
48
Fugue
71.95
15%
-60
- C2 -
3IB7
7
CPDA_MYCTU
A:
[16-310]
----------LR
A
A
E
H
P
R
P
D
Y
V
--
L
L
H
I
S
D
T
H
-
L
------
I
G
G
D
----------
R
----------
R
------
L
----------
Y
G
A
------
V
D
A
D
D
R
L
--------
G
--
E
------
L
L
-
E
Q
----
L
N
Q
S
G
L
R
P
D
A
I
V
F
T
G
D
L
A
D
---------
K
-
G
E
P
A
A
Y
R
-
K
L
R
G
L
---------
V
E
--
P
F
A
-
A
-------
Q
L
G
A
E
L
V
W
V
M
G
N
H
D
--------
D
R
---
A
E
L
--
R
K
F
---------
L
---
L
D
E
A
P
S
M
A
P
--------
L
D
--
R
-------
V
C
M
I
D
G
L
R
I
I
V
L
D
TSVPGH
H
H
-
G
E
I
R
-
A
-------
S
-
Q
L
G
-
W
-
L
----
A
----------
E
E
-
L
A
T
P
A
P
D
G
T
--
I
L
A
--
L
-----------
H
H
P
P
I
------
P
S
V
L
D
M
A
V
T
V
E
L
--
R
D
Q
A
A
L
-
G
R
V
L
R
G
T
D
V
R
A
I
L
A
G
HL
H
-------
Y
S
T
N
A
-------------------------
T
F
V
G
I
P
V
S
-
V
-
A
S
A
T
C
Y
T
Q
-
D
-
L
TVAAG
G
T
R
G
R
DGA
Q
G
C
N
L
V
H
V
Y
P
D
T
V
V
-----
H
---
S
V
I
P
L
GGGET
V
-----
G
T
F
V
S
-----------------------
P
G
-
Q
---------
A
----
R
R
K
I
A
E
S
G
I
F
I
E
P
-
S
R
-
R
-
D
-----------------------------------------------------
22
HHSearch
68.27
17%
-129
- C2 -
1Z2W
5
VPS29_MOUSE
A:
[11-167]
--------------------
M
L
--
V
L
V
L
G
D
L
H
-
I
------
P
H
R
C
----------
N
----------
S
------
L
----------
P
A
K
------
F
--
K
K
L
L
V-------
P
--
G
------
K
I
-
Q
H
----
I
L
C
T
G
N
L
C
T
K
------------------------
E
S
Y
-
D
Y
L
K
T
---------
L
----
A
G
-
D
-------
V
-----
H
I
V
R
G
D
F
D
--------
E
N
---
L
N
----
Y
----------------------
P
--------
E
Q
--
K
-------
V
V
T
V
G
Q
F
K
I
G
L
--------
I
H
-
G
H
Q
V
I
P
-------
W
-
G
D
----------------------------------------------------------------
M
----------------------------
A
S
L
----
A
-------
L
L
Q
R
Q
-------------------------
F
------------
D
V
D
I
L
I
-
S
-
G
-----------------
H
T
H
K
F
E
A
F
E
H
-----
E
-----
N
K
F
-----
Y
-----
I
N
P
G
S
-----------------------
A
T
-
G
AYNALETNI
I
----
P
S
F
V
L
M
D
I
Q
A
S
T
V
-
V
T
-
Y
-
V
Y
Q
---------------------------------------------------
27
HHSearch
68.24
20%
-123
- C2 -
1XM7
-
?
A:
[-1-174]
--------------------
A
M
--
M
Y
F
I
S
D
T
H
-
F
------
Y
H
E
N
----------
I
I
---------
N
------
L
N
PEVRFKG
F
E
I
V
I
------
L
--
T
N
L
L
--------
K
V
L
K
------
P
E
-
D
T
----
L
Y
H
L
G
D
F
T
W
H
F
N
--
D
-----------------
K
N
E
Y
L
-
R
I
W
K
A
---------
L
----
P
G
-
R
-------
K
-----
I
L
V
M
G
N
H
D
--------
K
D
---
K
E
S
--
L
K
E
-------------
Y
F
D
--
E
I
Y
D
--------
F
Y
--
K
-------
I
I
E
H
K
G
K
R
I
L
L
--------
S
H
-
Y
P
A
K
D
P
-------
I
-
T
E
---------------------------
R
------------------------------------
Y
-
P
----
D
---------------
R
Q
----
E
M
V
----
R
-------
E
I
Y
F
K
-------------------------
E
------------
N
C
D
L
L
I
-
H
-
G
-----------------
H
V
H
W
N
R
E
G
--CACKD
Y
-----
R
I
E
-----
C
-----
I
N
A
N
V
-----------------------
E
W
-
N
---------
D
----
Y
K
P
I
S
E
R
E
I
D
K
L
I
------------------------------------------------------------
31
HHSearch
68.16
13%
-121
- C2 -
2A22
-
?
A:
[4-172]
-----------------
D
F
G
D
L
--
V
L
L
I
G
D
L
K
-
I
------
P
Y
G
A
----------
K
----------
E
L-----
P
----------
S
N
F
------
R
--
E
L
L
A
--------
T
--
D
------
K
I
-
N
Y
----
V
L
C
T
G
N
V
C
S
Q
----
E
--------------------
Y
V
-
E
M
L
K
N
---------
I
----
T
K
-
N
-------
V
-----
Y
I
V
S
G
D
L
D
--------
S
A
---
I
F
N
--
P
D
P
-------------
E
--
S
N
G
V
F
P
--------
E
Y
--
V
-------
V
V
Q
I
G
E
F
K
I
G
L
--------
M
H
-
G
N
Q
V
L
P
-------
W
--
D
---------------------------------------------------------------------------------------
D
P
----
G
S
L
----
E
-------
Q
W
Q
R
R
-------------------------
L
------------
D
C
D
I
L
V
-
T
-
G
-----------------
H
T
H
K
L
R
V
F
E
K
-----
N
-----
G
K
L
-----
F
-----
L
N
P
G
T
-----------------------
A
T
-
G
AFSALTPDA
P
----
P
S
F
M
L
M
A
L
Q
G
N
K
V
-
V
L
-
Y
-
V
Y
D
---------------------------------------------------
45
Fugue
67.47
17%
-93
- C2 -
1XM7
-
?
A:
[-1-186]
--------------------
A
M
--
M
Y
F
I
S
D
T
H
-
F
------
Y
H
E
N
----------
I
----------
I
------
N
----------
L
N
P
EVRFKG
F
--
E
I
V
I
--------
L
--
T
------
N
L
-
L
K
----
V
L
K
P
E
D
T
L
Y
H
L
G
--
D
F
T
W
H
---------
F
-
N
D
K
N
E
Y
L
-
R
I
W
K
A
---------
L
P
----
G
-
R
-------
K
-----
I
L
V
M
G
N
H
D
--------
K
D
---
K
E
S
--
L
K
E
---------
Y
---
F
D
E
I
Y
D
-----------
F
Y
--
K
-------
I
I
E
H
K
G
K
R
I
L
L
--------
S
H
-
Y
P
A
K
D
P
-------
I
-
T
E
R
-
Y
-------------------------------------------------------------------------------------
P
D
R
Q
E
M
V
R
----
E
-------
I
Y
F
K
--------------------------------------
E
N
C
D
L
L
I
-
H
-
G
-----------------
H
V
H
W
N
R
E
G
C
A
-----
C
---
K
D
Y
R
I
-----
E
-----
C
I
N
A
N
-----------------------
V
E
-
W
--------------
N
D
Y
K
P
I
S
E
R
E
I
D
K
-
L
I
---------------------------------------------------------
25
HHSearch
65.95
17%
-136
- C2 -
2KKN
-
?
A:
[1-147]
-------------------
V
K
R
--
F
L
L
I
S
D
S
H
-
V
------
P
V
R
M
----------
A
----------
S
------
L
P---------
D
E
I
------
L
--
N
S
L
------------
K
------
E
Y
-
D
G
----
V
I
G
L
G
D
Y
V
D
L
D
T
------------------------
V
-
I
L
L
E
K
---------
F
----
S
K
-
E
-------
F
-----
Y
G
V
H
G
N
M
D
--------
Y
P
---
D
V
K
--
E
---------------------
H
L
P
--------
F
S
--
K
-------
V
L
L
V
E
G
V
T
I
G
M
--------
C
H
-
G
W
G
A
P
W
---------
D
-----------------------------------------------------------------
L
K
---------------------------
D
R
L
----
L
-------
K
V
F
-
N
-------------------------
E
------------
K
P
Q
V
I
L
-
F
-
G
-----------------
H
T
H
E
P
E
D
T
V
K
-----
A
-----
G
V
R
-----
F
-----
L
N
P
G
S
-----------------------
L
A
-----------
E
----
G
S
Y
A
V
L
E
L
D
G
G
E
V
-
R
F
-
E
-
L
K
T
---------------------------------------------------
44
Fugue
65.71
14%
-80
- C2 -
1W24
-
VPS29_HUMAN
A:
[1-182]
--------------------
M
L
--
V
L
V
L
G
D
L
H
-
I
------
P
H
R
C
----------
N
----------
S
------
L
----------
P
A
K
------
F
--
K
K
L
L
--------
V
--
P
------
G
K
I
Q
H
----
I
L
C
T
G
N
L
C
------------------------
T
K
E
S
Y
-
D
Y
L
K
T
---------
L
A
--
G
---
D
-------
V
-----
H
I
V
R
G
D
F
D
--------
E
N
-----------------------------
L
N
Y
P
--------
E
Q
--
K
-------
V
V
T
V
G
Q
F
K
I
G
L
--------
I
H
-
G
H
Q
V
I
P
-------
D
-
M
A
S
-
L
-
A
----
L
----------
L
Q
-
R
Q
F
D
V
D
I
L
I
--
S
G
H
--
T
-----------
H
K
F
E
A
------
F
E
H
----
E
N
K
F
Y
--
I
N
P
---------------------------------------------------------------------------
G
S
A
-
T
-
G
-----------------
A
Y
N
A
L
E
T
N
I
I
-----
P
---
S
F
V
L
M
-----
D
-----
I
Q
A
S
T
-----------------------
V
V
-
T
---------
Y
----
V
Y
Q
L
I
G
D
D
V
K
V
E
R
-
I
E
-
Y
-
K
K
P
---------------------------------------------------
30
HHSearch
65.54
17%
-113
- C2 -
3CK2
4
?
A:
[3-151]
----------------
A
M
A
K
Q
T
--
I
I
V
M
S
D
S
H
-
G
------
D
S
L
I
----------------------------
V
----------
E
E
V
------
R
--
D
R
Y
V
-----------
G
------
K
V
-
D
A
----
V
F
H
N
G
D
S
E
L
R
P
D
--
S
-------------------
P
-----
L
----------------
W
E
-
G
-------
I
-----
R
V
V
K
G
N
M
D
--------
F
Y
---
A
G
Y
----
P
------------------------------
E
R
--
L
-------
V
T
E
L
G
S
T
K
I
I
Q
--------
T
H
-
G
H
L
F
D
I
-------
N
-
F
N
----------------------------------------------------------------------------------------
F
----
Q
K
L
----
D
-------
Y
W
A
Q
E
-------------------------
E
------------
E
A
A
I
C
L
-
Y
-
G
-----------------
H
L
H
V
P
S
A
W
L
E
-----
G
-----
K
I
L
-----
F
-----
L
N
P
G
S
-----------------------
I
S
-
Q
PRGTIR---
E
----
C
L
Y
A
R
V
E
I
D
D
S
Y
F
-
K
V
-
D
-
F
L
T
---------------------------------------------------
21
HHSearch
64.62
14%
-117
- C2 -
1S3L
2
P936_METJA
A:
[26-183]
--------------------
M
K
--
I
G
I
M
S
D
T
H
-
D
------
H
L
P
N
----------------------------
I
----------
R
K
A
------
I
--
E
I
F
N
--------
D
--
E
------
N
V
-
E
T
----
V
I
H
C
G
D
F
V
S
L
F
------------------------
V
I
-
K
E
F
E
N
---------
L
----
N
A
-
N
-------
I
-----
I
A
T
Y
G
N
N
D
--------
G
E
---
R
C
K
--
L
K
E
---------
W
L
K
-
D
I
N
E
E
N
I
I
D
--------
D
F
--
I
-------
S
V
E
I
D
D
L
K
F
F
I
--------
T
H
-
G
H
H
Q
S
V
----------------------------------------------------------------------------------------------------------
L
----
E
-------
M
A
I
K
S
-------------------------
G
------------
L
Y
D
V
V
I
-
Y
-
G
-----------------
H
T
H
E
R
V
F
E
E
V
-----
D
-----
D
V
L
-----
V
-----
I
N
P
G
E
-----------------------
C
C
-
G
---------
Y
LTG
I
P
T
I
G
I
L
D
T
E
K
K
E
Y
-
R
E
-
I
-
V
L
----------------------------------------------------
42
Fugue
64.49
14%
-67
- C2 -
2NXF
6
ADPRM_DANRE
A:
[3-322]
DPV
F
T
F
G
L
I
A
DV
Q
Y
A
D
I
E
D
G
E
N
--
Y
L
R
T
R
R
R
Y
-
Y
------
R
G
S
A
----------
D
----------
L
------
L
----------
R
D
A
------
V
--
L
Q
W
R
--------
R
--
E
------
R
V
-
Q
C
----
V
V
Q
L
G
D
I
I
D
G
H
N
--
R
R
R
D
A
---------
S
-
D
R
A
L
D
T
V
M
A
E
L
D
A
---------
C
S
----
V
-
D
-------
V
-----
H
H
V
W
G
N
H
E
--------
F
Y
N
FS
R
P
S
--
L
L
S
---------
S
---
R
L
N
S
A
Q
G
S
D
--------
L
I
--
G
DDIY
A
Y
E
F
S
P
A
P
N
F
R
F
V
L
--------
L
D
-
A
Y
D
L
S
V
-------
I
-
G
R
E
-
E
-
E
----
S
----------
E
K
-
H
T
H
S
W
R
I
L
T
--
Q
H
N
HN
L
-----------
Q
D
L
N
L
------
P
P
V
S
V
G
L
E
Q
R
F
V
--
K
F
N
G
G
F
-
S
E
Q
-
Q
L
Q
W
L
D
A
V
L
----
T
-------
L
S
D
H
K
Q
E
R
V
L
I
F
S
HLPVHPCAADPICLAWN
H
E
A
V
L
S
V
L
R
S
-
H
Q
S
V
L
C
F
I
-
A
-
G
-----------------
H
D
H
D
G
G
R
C
T
D
-----
S
---
S
G
A
Q
H
-----
I
-----
T
L
E
G
V
-----------------------
I
E
-
T
---------
P
----
P
H
S
H
A
F
A
T
A
Y
L
Y
E
-
D
R
M
V
M
K
G
R
GR
V
E
D
L
T
I
T
Y
S----------------------------------------
49
Fugue
64.05
17%
-101
- C2 -
3T1I
10
MRE11_HUMAN
A:
[27-420]
------------
L
D
D
E
N
T
F
K
----
I
L
V
A
T
D
I
H
-
L
GFMEKD
A
V
R
G
----------
N
----------
D
------
T
----------
F
V
T
------
L
--
D
E
I
L
--------
R
--
L
------
A
Q
-
E
N
EVD
F
I
L
L
G
G
D
L
F
H
-----
E
N
K
P
S
---------
R
-
K
T
L
H
T
C
L
-
E
L
L
R
K
YCMGDRPVQ
F
E
--
I
L
S
-
D
QLNIS
I
P
V
-----
F
S
I
H
G
N
H
D
DPTGADAL
C
A
---
L
D
I
--
L
S
C
---------
A
---
G
F
V
N
H
F
G
R
S
MSVE
K
I
D
I
S
P
--
V
-------
L
L
Q
K
G
S
T
K
I
A
L
--------
Y
G
L
G
S
I
P
D
E
-------
R
-
L
Y
R
M
F
-
V
N
KK
V
T
M
---------
L
R
-
P
K
E
D
E
N
S
W
F
--
N
L
F
--
V
I
H
Q
N
RSKHGST
N
F
I
P
E
------
Q
F
L
D
D
F
I
D
L
V
I
W
GH
E
H
E
C
K
I
-
A
P
T
-
K
N
E
Q
Q
L
F
Y
I
----
S
Q
P
G
S
SVV
T
S
L
S
P
-------------------------
G
E
A
V
K
K
H
V
-
G
-
L
L
R
I
K
G
R
K
M
N
M
H
-----------------
K
I
P
L
H
T
V
R
Q
F
-----
F
M
--
E
D
I
V
L
-----
A
NHPDI
F
N
P
D
N
-----------------------
P
K
-
V
---------
T
----
Q
A
I
Q
S
F
C
L
E
K
I
E
E
M
L
E
-
N
-
A
E
R
E
R
LGNSHQPE
K
P
L
V
R
L
R
V
D
YSG
G
F
E
P
F
S
V
L
R
F
S
Q
K
F
V
DRVANPKDIIHFFR
50
Fugue
62.60
13%
-79
- C2 -
2QJC
3
?
A:
[8-249]
---------Y
A
N
V
V
T
L
P
N
V
T
G
R
--
V
I
I
V
G
D
I
H
G
C
------
R
A
Q
L
----------
E
----------
D
------
L
----------
L
R
A
------
V
--
S
--
F
--------
K
--
Q
------
G
S
-
D
T
----
L
V
A
V
G
D
----
L
V
--
N
K
G
P
-------------
D
S
F
G
V
V
-
R
L
L
K
R
---------
L
G
--------------
A
-----
Y
S
V
L
G
N
H
D
--------
A
K
---
L
L
K
--
L
V
K
---------
K
---
L
----
S
L
A
P
--------
L
A
--
Q
-------
S
I
P
T
D
V
E
T
Y
L
S
--------
Q
L
-
P
H
I
I
R
I
-------
P
-
A
H
N
-
V
M
V
----
A
----------
H
A
G
L
H
P
Q
R
P
----------------------------------------
V
D
R
Q
Y
--
E
D
E
V
T
T
M
R
N
L
-
I
E
K
V
T
L
T
A
T
----
E
-------
E
T
N
D
G
-------------------------
G
K
P
W
---
A
-
S
M
W
R
G
P
E
T
V
V
-
F
-
G
-----------------
H
D
A
R
R
G
L
Q
E
Q
-----
Y
---
K
P
L
A
I
-----
G
-----
L
D
S
R
C
-----------------------
V
Y
G
G
---------
R
----
L
S
A
A
V
F
P
G
G
C
I
I
S
-
V
P
-
G
-
W
N
G
---------------------------------------------------
38
HHSearch
56.95
24%
-131
- C2 -
3D03
2
?
A:
[1-86]
--------------------
M
L
--
L
A
H
I
S
D
T
H
-
F
------
R
S
R
G
----------
E
KLYGFID
V
N
A
A
------
N
----------
A
D
V
------
V
--
S
Q
L
N
--------
A
LR
E
------
R
P
-
D
A
----
V
V
V
S
G
D
I
V
N
C
G
R
----
P
-------------
E
E
Y
Q
V
A
R
-
Q
I
L
G
S
---------
L
----
N
Y
-
P
-------
L
-----
Y
L
I
P
G
N
H
D
--------
D
K
---
A
L
F
--
L
E
Y
---------
L
---
Q
P
L
C
P
Q
L
G
S
--------
D
A
--
N
-------
N
M
R
C
A
V
D
D
F
A
T
--------
R
L
-
L
F
I
D
S
S
-------
R
-
A
G
T
-
S
-
K
----
G
----------
W
L
-
T
D
E
T
I
S
W
L
E
--
A
Q
L
--
F
-----------
E
G
G
D
K
------
P
A
T
I
F
M
H
H
P
P
L
P
--
L
G
N
A
Q
M
-
D
P
I
-
A
C
E
N
G
H
R
L
L
----
A
-------
L
V
E
R
F
-------------------------
P
S
L
T
R
I
F
C
-
G
-
H
N
H
S
L
T
M
T
-
Q
-
Y
-----------------
R
Q
A
L
I
S
T
L
P
G
-----
T
---
V
H
Q
V
P
-----
Y
-----
C
H
A
D
T
-----------------------
D
P
-
Y
---------
Y
----
D
L
S
P
A
S
C
L
M
H
R
Q
V
-
G
E
-
Q
-
W
V
S
---------------------------------------------------
46
Fugue
55.32
15%
-104
- C2 -
1S3L
2
P936_METJA
A:
[26-190]
--------------------
M
K
--
I
G
I
M
S
D
T
H
---------
D
H
L
----------
P
----------
N
------
I
----------
R
K
A
------
I
--
E
I
F
N
--------
D
--
E
------
N
V
-
E
T
----
V
I
H
C
G
D
F
------------------------
V
S
L
F
V
I
-
K
E
F
E
N
---------
L
N
----
A
-
N
-------
I
-----
I
A
T
Y
G
N
N
D
--------
G
E
---
R
C
K
--
L
K
E
---------
W
---
L
K
D
I
N
E
E
N
I
--------
I
D
D
F
I
-------
S
V
E
I
D
D
L
K
F
F
I
--------
T
H
-
G
H
H
Q
S
V
-------
L
-
E
M
A
-
I
-
K
----
S
GLYDVVIYGH
T
H
-
E
R
V
F
E
E
V
D
D
--
V
L
V
--
I
-----------
N
P
G
E
C
CGYLTG
I
P
T
I
G
I
L
D
--
T
E
--
K
K
E
Y
R
E
-
I
V
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------