@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_0989: (2015-12-19 )
MDDLQEIMEDFLIEAFEMNEQLDQDLVELEHNPEDLDLLNRIFRVAHTIKGSSSFLNLNILTHLTHNMEDVLNRARKGEIKITPDIMDVVLRSIDLMKTLLVTIRDTGSDTNNGKENEIEEVVKKLQAITSQNLEGAKETSGTKEAPEKEVKKENKEKAKEEVKANKTPTTENLTSDNPLADEPDLDYANMSAEEVEAEIERLLNKRQEADKERRAQKKQEDQAKPKQEVAPAKETPKTETPKTETRKVPKAETKAKAKADTEENKAPSIGVEQTVRVDVRRLDHLMNLIGELVLGKNRLIRIYSDVEERYDGEKFLEELNQVVSSISAVTTDLQLAVMKTRMQPVGKVFNKFPRMVRDLSRELGKSIELIIEGEETELDKSIVEEIGDPLIHIIRNSCDHGIEPLEERRRLNKPETGKVQLSAYNEGNHIVIKISDDGKGLDPVMLKEKAIEKGVISERDAESMSDREAFNLIFKPGFSTRKVVSNVSGRGVGMDVVKTNIEKLNGIIEIDSEVGVGTTQKLKIPLTLAIIQALLVGVQEEYYAIPLSSVLETVRISQDEIYTVDGKSVLRLRDEVLSLVRLSDIFKVDAILESNSDVYVVIIGLADQKIGVIVDYLIGQEEVVIKSLGYYLKNTRGIAGATVRGDGKITLIVDVGAMMEMAKSIKVNITTLMNESENTKSKNSPSDYVVLAIDDSSTDRAIIRKCLKPLGITLLEATNGLEGLEMLKNGDKIPDAILVDIEMPKMDGYTFASEVRKYNKFKNLPLIAVTSRVTKTDRMRGVESGMTEYITKPYSGEYLTTVVKRSIKLEGDQS
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710..-.....720.......730.......740.......750.......760.......770.......780.......790.......800.......810...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
D
D
L
Q
E
I
M
E
D
F
L
I
E
A
F
E
M
N
E
Q
L
D
Q
D
L
V
ELEHNPE
D
L
D
L
L
N
R
I
F
R
V
A
H
TIKGSS
S
F
L
N
L
N
I
L
T
H
L
T
H
N
M
E
D
V
L
N
RARKG
E
I
K
I
T
P
D
I
M
D
V
V
L
R
S
I
D
L
M
K
T
L
L
V
T
I
RDTGSDTNNG
K
E
N
E
I
E
E
V
V
K
K
L
Q
A
I
T
SQNLEGAKETSGTKEA
P
E
K
E
V
K
K
E
N
K
E
K
A
K
E
E
V
KANKTPTTENLTSDNPLADEPDLDYANM
S
A
E
E
V
E
A
E
I
E
R
L
L
N
K
R
Q
E
A
D
K
E
R
R
A
Q
K
K
Q
E
DQAK
P
K
Q
EVAPAKETPKTETPKTETRKVPKAETKAKAKADTEENKAPSIGV
E
Q
T
V
R
V
D
V
R
R
L
D
H
L
M
N
L
I
G
E
L
V
LGKN
R
L
I
R
I
Y
S
D
V
E
E
RY
D
G
E
K
F
L
E
E
L
N
Q
V
V
S
S
I
S
A
V
T
T
D
L
Q
L
A
V
M
K
T
R
M
Q
P
V
G
K
V
F
N
K
F
P
R
M
V
R
D
L
S
R
E
LGK
S
I
E
L
I
I
EGEETEL
D
K
S
I
V
E
E
IG
D
P
L
I
H
I
I
R
N
SCDHGIE
P
L
E
E
R
RRLNKPET
G
K
V
Q
L
S
A
YNEG
N
H
I
V
I
K
ISDDGKGL
D
P
V
M
L
K
E
K
A
I
EKGVISER
D
A
E
SMSDRE
A
F
N
L
I
FKPGF
S
T
R
K
V
V
S
NVSGRGV
G
M
D
V
V
K
T
N
I
E
KLN
G
I
I
E
IDSEVGVGT
T
Q
K
L
K
I
P
L
T
L
A
I
I
Q
A
L
L
V
G
VQEE
Y
Y
AI
P
L
S
S
V
L
E
T
V
RISQD
E
I
Y
TVD
G
K
S
V
L
R
L
R
D
E
V
L
S
L
V
R
L
S
D
I
F
K
V
D
A
I
LESNS
D
V
Y
V
V
I
I
GLADQ
K
I
G
V
I
V
D
Y
LIG
Q
E
E
V
V
I
K
S
L
G
Y
Y
L
KNTRGIA
G
A
T
V
RGD
G
K
I
T
L
I
V
D
V
G
A
M
M
E
M
A
K
S
I
K
V
N
I
T
T
L
MNESENTKSKNSPS
D
Y
V
V
L
A
IDDSST
D
R
A
I
I
R
K
C
L
K
P
LG
I
T
-
L
L
EATNGL
E
G
L
E
M
L
KNGDKIP
D
A
I
L
V
D
IEMPKMDG
Y
T
F
A
S
E
V
R
K
Y
N
KFKNL
P
L
I
A
V
TSRVT
K
T
D
R
M
R
G
V
E
S
G
M
T
E
Y
ITKPYS
G
E
Y
L
T
T
V
V
K
R
S
I
KLEGDQS
21
PsiBlast_CBE
77.64
45%
-101
- C3 -
1B3Q
1
CHEA_THEMA
B:
[2-378]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
T
V
R
V
D
I
E
K
L
D
N
L
M
D
L
M
G
E
L
V
I
A
R
S
R
I
L
----
E
T
L
K
K
Y
N
----
I
K
E
L
D
E
S
L
S
H
L
S
R
I
T
L
D
L
Q
N
V
V
M
K
I
R
M
V
P
I
S
F
V
F
N
R
F
P
R
M
V
R
D
L
A
K
K
M
N
K
E
V
N
F
I
M
R
G
E
D
T
E
L
D
R
T
F
V
E
E
I
G
E
P
L
L
H
L
L
R
N
A
I
D
H
G
I
E
P
K
E
E
R
I
A
K
G
K
P
P
I
G
T
L
I
L
S
A
R
H
E
G
N
N
V
V
I
E
V
E
D
D
G
R
G
I
D
K
E
K
I
I
R
K
A
I
E
K
G
L
I
D
E
S
K
A
A
T
L
S
D
Q
E
I
L
N
F
L
F
V
P
G
F
S
T
K
E
K
V
S
E
V
S
G
R
G
V
G
M
D
V
V
K
N
V
V
E
S
L
N
G
S
M
G
I
E
S
E
K
D
K
G
T
K
V
T
I
R
L
P
L
T
L
A
I
I
C
A
L
L
V
K
V
N
N
L
V
Y
A
I
P
I
A
N
I
D
T
I
L
S
I
S
K
E
D
I
Q
R
V
Q
D
R
D
V
I
V
I
R
G
E
V
I
P
V
Y
R
L
W
E
V
L
Q
I
---------
M
E
A
V
I
V
R
V
G
N
R
K
Y
G
I
V
V
D
D
L
L
G
Q
D
D
I
V
I
K
S
L
G
K
V
F
S
E
V
K
E
F
S
G
A
A
I
L
G
D
G
S
I
A
L
I
I
N
V
S
G
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
77.33
45%
-101
- C3 -
1B3Q
1
CHEA_THEMA
A:
[2-379]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
T
V
R
V
D
I
E
K
L
D
N
L
M
D
L
M
G
E
L
V
I
A
R
S
R
I
L
----
E
T
L
K
K
Y
N
----
I
K
E
L
D
E
S
L
S
H
L
S
R
I
T
L
D
L
Q
N
V
V
M
K
I
R
M
V
P
I
S
F
V
F
N
R
F
P
R
M
V
R
D
L
A
K
K
M
N
K
E
V
N
F
I
M
R
G
E
D
T
E
L
D
R
T
F
V
E
E
I
G
E
P
L
L
H
L
L
R
N
A
I
D
H
G
I
E
P
K
E
E
R
I
A
K
G
K
P
P
I
G
T
L
I
L
S
A
R
H
E
G
N
N
V
V
I
E
V
E
D
D
G
R
G
I
D
K
E
K
I
I
R
K
A
I
E
K
G
L
I
D
E
S
K
A
A
T
L
S
D
Q
E
I
L
N
F
L
F
V
P
G
F
S
-----------
G
V
G
M
D
V
V
K
N
V
V
E
S
L
N
G
S
M
G
I
E
S
E
K
D
K
G
T
K
V
T
I
R
L
P
L
T
L
A
I
I
C
A
L
L
V
K
V
N
N
L
V
Y
A
I
P
I
A
N
I
D
T
I
L
S
I
S
K
E
D
I
Q
R
V
Q
D
R
D
V
I
V
I
R
G
E
V
I
P
V
Y
R
L
W
E
V
L
Q
I
E
H
-
K
E
E
L
E
E
M
E
A
V
I
V
R
V
G
N
R
K
Y
G
I
V
V
D
D
L
L
G
Q
D
D
I
V
I
K
S
L
G
K
V
F
S
E
V
K
E
F
S
G
A
A
I
L
G
D
G
S
I
A
L
I
I
N
V
S
G
I
V
------------------------------------------------------------------------------------------------------------------------------------------------------------
101
HHSearch
76.10
47%
-102
- C3 -
1B3Q
1
CHEA_THEMA
A:
[2-378]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
T
V
R
V
D
I
E
K
L
D
N
L
M
D
L
M
G
E
L
V
I
A
R
S
R
I
L
E
T
L
K
K
Y
N
--------
I
K
E
L
D
E
S
L
S
H
L
S
R
I
T
L
D
L
Q
N
V
V
M
K
I
R
M
V
P
I
S
F
V
F
N
R
F
P
R
M
V
R
D
L
A
K
K
M
N
K
E
V
N
F
I
M
R
G
E
D
T
E
L
D
R
T
F
V
E
E
I
G
E
P
L
L
H
L
L
R
N
A
I
D
H
G
I
E
P
K
E
E
R
I
A
K
G
K
P
P
I
G
T
L
I
L
S
A
R
H
E
G
N
N
V
V
I
E
V
E
D
D
G
R
G
I
D
K
E
K
I
I
R
K
A
I
E
K
G
L
I
D
E
S
K
A
A
T
L
S
D
Q
E
I
L
N
F
L
F
V
P
G
F
S
-----------
G
V
G
M
D
V
V
K
N
V
V
E
S
L
N
G
S
M
G
I
E
S
E
K
D
K
G
T
K
V
T
I
R
L
P
L
T
L
A
I
I
C
A
L
L
V
K
V
N
N
L
V
Y
A
I
P
I
A
N
I
D
T
I
L
S
I
S
K
E
D
I
Q
R
V
Q
D
R
D
V
I
V
I
R
G
E
V
I
P
V
Y
R
L
W
E
V
L
Q
I
E
H
K
E
E
-
L
E
E
M
E
A
V
I
V
R
V
G
N
R
K
Y
G
I
V
V
D
D
L
L
G
Q
D
D
I
V
I
K
S
L
G
K
V
F
S
E
V
K
E
F
S
G
A
A
I
L
G
D
G
S
I
A
L
I
I
N
V
S
G
I
V
------------------------------------------------------------------------------------------------------------------------------------------------------------
123
Fugue
72.20
47%
-100
- C3 -
2CH4
1
CHEA_THEMA
A:
[1-320]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
H
M
V
P
I
S
F
V
F
N
R
F
P
R
M
V
R
D
L
A
K
K
M
N
K
E
V
N
F
I
M
R
G
E
D
T
E
L
D
R
T
F
V
E
E
I
G
E
P
L
L
H
L
L
R
N
A
I
D
H
G
I
E
P
K
E
E
R
I
A
K
G
K
P
P
I
G
T
L
I
L
S
A
R
H
E
G
N
N
V
V
I
E
V
E
D
D
G
R
G
I
D
K
E
K
I
I
R
K
A
I
E
K
G
L
I
D
E
S
K
A
A
T
L
S
D
Q
E
I
L
N
F
L
F
V
P
G
F
S
T
K
E
K
V
S
E
V
S
G
R
G
V
G
M
D
V
V
K
N
V
V
E
S
L
N
G
S
I
S
I
E
S
E
K
D
K
G
T
K
V
T
I
R
L
P
L
T
L
A
I
I
Q
A
L
L
V
K
V
N
N
L
V
Y
A
I
P
I
A
N
I
D
T
I
L
S
I
S
K
E
D
I
Q
R
V
Q
D
R
D
V
I
V
I
R
G
E
V
I
P
V
Y
R
L
W
E
V
L
Q
I
E
H
-
K
E
E
L
E
E
M
E
A
V
I
V
R
V
G
N
R
K
Y
G
I
V
V
D
D
L
L
G
Q
D
D
I
V
I
K
S
L
G
K
V
F
S
E
V
K
E
F
S
G
A
A
I
L
G
D
G
S
I
A
L
I
I
N
V
S
G
I
V
------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
72.00
47%
-101
- C3 -
2CH4
1
CHEA_THEMA
A:
[2-320]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
H
M
V
P
I
S
F
V
F
N
R
F
P
R
M
V
R
D
L
A
K
K
M
N
K
E
V
N
F
I
M
R
G
E
D
T
E
L
D
R
T
F
V
E
E
I
G
E
P
L
L
H
L
L
R
N
A
I
D
H
G
I
E
P
K
E
E
R
I
A
K
G
K
P
P
I
G
T
L
I
L
S
A
R
H
E
G
N
N
V
V
I
E
V
E
D
D
G
R
G
I
D
K
E
K
I
I
R
K
A
I
E
K
G
L
I
D
E
S
K
A
A
T
L
S
D
Q
E
I
L
N
F
L
F
V
P
G
F
S
T
K
E
K
V
S
E
V
S
G
R
G
V
G
M
D
V
V
K
N
V
V
E
S
L
N
G
S
I
S
I
E
S
E
K
D
K
G
T
K
V
T
I
R
L
P
L
T
L
A
I
I
Q
A
L
L
V
K
V
N
N
L
V
Y
A
I
P
I
A
N
I
D
T
I
L
S
I
S
K
E
D
I
Q
R
V
Q
D
R
D
V
I
V
I
R
G
E
V
I
P
V
Y
R
L
W
E
V
L
Q
I
E
H
-
K
E
E
L
E
E
M
E
A
V
I
V
R
V
G
N
R
K
Y
G
I
V
V
D
D
L
L
G
Q
D
D
I
V
I
K
S
L
G
K
V
F
S
E
V
K
E
F
S
G
A
A
I
L
G
D
G
S
I
A
L
I
I
N
V
S
G
I
V
------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
70.63
47%
-102
- C3 -
2CH4
1
B:
[2-320]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
H
M
V
P
I
S
F
V
F
N
R
F
P
R
M
V
R
D
L
A
K
K
M
N
K
E
V
N
F
I
M
R
G
E
D
T
E
L
D
R
T
F
V
E
E
I
G
E
P
L
L
H
L
L
R
N
A
I
D
H
G
I
E
P
K
E
E
R
I
A
K
G
K
P
P
I
G
T
L
I
L
S
A
R
H
E
G
N
N
V
V
I
E
V
E
D
D
G
R
G
I
D
K
E
K
I
I
R
K
A
I
E
K
G
L
I
D
E
S
K
A
A
T
L
S
D
Q
E
I
L
N
F
L
F
V
P
G
F
S
--------------
M
D
V
V
K
N
V
V
E
S
L
N
G
S
I
S
I
E
S
E
K
D
K
G
T
K
V
T
I
R
L
P
L
T
L
A
I
I
Q
A
L
L
V
K
V
N
N
L
V
Y
A
I
P
I
A
N
I
D
T
I
L
S
I
S
K
E
D
I
Q
R
V
Q
D
R
D
V
I
V
I
R
G
E
V
I
P
V
Y
R
L
W
E
V
L
Q
I
E
H
-
K
E
E
L
E
E
M
E
A
V
I
V
R
V
G
N
R
K
Y
G
I
V
V
D
D
L
L
G
Q
D
D
I
V
I
K
S
L
G
K
V
F
S
E
V
K
E
F
S
G
A
A
I
L
G
D
G
S
I
A
L
I
I
N
V
S
G
I
V
------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
64.57
47%
-108
- C5 -
3UR1
-
CHEA_THEMA
A:
[353-671]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
H
M
V
P
I
S
F
V
F
N
R
F
P
R
M
V
R
D
L
A
K
K
M
N
K
E
V
N
F
I
M
R
G
E
D
T
E
L
D
R
T
F
V
E
E
I
G
E
P
L
L
H
L
L
R
N
A
I
D
H
G
I
E
P
K
E
E
R
I
A
K
G
K
P
P
I
G
T
L
I
L
S
A
R
H
E
G
N
N
V
V
I
E
V
E
D
D
---------------------------------------------------------
D
V
V
K
N
V
V
E
S
L
N
G
S
I
S
I
E
S
E
K
D
K
G
T
K
V
T
I
R
L
P
L
T
L
A
I
I
Q
A
L
L
V
K
V
N
N
L
V
Y
A
I
P
I
A
N
I
D
T
I
L
S
I
S
K
E
D
I
Q
R
V
Q
D
R
D
V
I
V
I
R
G
E
V
I
P
V
Y
R
L
W
E
V
L
Q
I
E
H
-
K
E
E
L
E
E
M
E
A
V
I
V
R
V
G
N
R
K
Y
G
I
V
V
D
D
L
L
G
Q
D
D
I
V
I
K
S
L
G
K
V
F
S
E
V
K
E
F
S
G
A
A
I
L
G
D
G
S
I
A
L
I
I
N
V
S
G
I
V
------------------------------------------------------------------------------------------------------------------------------------------------------------
124
Fugue
64.31
44%
-113
* C5 *
3UR1
-
CHEA_THEMA
A:
[352-671]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
H
M
V
P
I
S
F
V
F
N
R
F
P
R
M
V
R
D
L
A
K
K
M
N
K
E
V
N
F
I
M
R
G
E
D
T
E
L
D
R
T
F
V
E
E
I
G
E
P
L
L
H
L
L
R
N
A
I
D
H
G
I
E
P
K
E
E
R
I
A
K
G
K
P
P
I
G
T
L
I
L
S
A
R
H
E
G
N
N
V
V
I
E
V
E
---------------------------------------------------------
D
D
D
V
V
K
N
V
V
E
S
L
N
G
S
I
S
I
E
S
E
K
D
K
G
T
K
V
T
I
R
L
P
L
T
L
A
I
I
Q
A
L
L
V
K
V
N
N
L
V
Y
A
I
P
I
A
N
I
D
T
I
L
S
I
S
K
E
D
I
Q
R
V
Q
D
R
D
V
I
V
I
R
G
E
V
I
P
V
Y
R
L
W
E
V
L
Q
I
E
H
-
K
E
E
L
E
E
M
E
A
V
I
V
R
V
G
N
R
K
Y
G
I
V
V
D
D
L
L
G
Q
D
D
I
V
I
K
S
L
G
K
V
F
S
E
V
K
E
F
S
G
A
A
I
L
G
D
G
S
I
A
L
I
I
N
V
S
G
I
V
------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
56.40
54%
-43
- C3 -
1I5C
1
CHEA_THEMA
A:
[2-189]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
H
M
V
P
I
S
F
V
F
N
R
F
P
R
M
V
R
D
L
A
K
K
M
N
K
E
V
N
F
I
M
R
G
E
D
T
E
L
D
R
T
F
V
E
E
I
G
E
P
L
L
H
L
L
R
N
A
I
D
H
G
I
E
P
K
E
E
R
I
A
K
G
K
P
P
I
G
T
L
I
L
S
A
R
H
E
G
N
N
V
V
I
E
V
E
D
D
G
R
G
I
D
K
E
K
I
I
R
K
A
I
E
K
G
L
I
D
E
S
K
A
A
T
L
S
D
Q
E
I
L
N
F
L
F
V
P
G
F
S
T
K
E
-------
R
G
V
G
M
D
V
V
K
N
V
V
E
S
L
N
G
S
I
S
I
E
S
E
K
D
K
G
T
K
V
T
I
R
L
P
L
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
55.10
54%
-45
- C3 -
1I58
2
B:
[3-189]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
M
V
P
I
S
F
V
F
N
R
F
P
R
M
V
R
D
L
A
K
K
M
N
K
E
V
N
F
I
M
R
G
E
D
T
E
L
D
R
T
F
V
E
E
I
G
E
P
L
L
H
L
L
R
N
A
I
D
H
G
I
E
P
K
E
E
R
I
A
K
G
K
P
P
I
G
T
L
I
L
S
A
R
H
E
G
N
N
V
V
I
E
V
E
D
D
G
R
G
I
D
K
E
K
I
I
R
K
A
I
E
K
G
L
I
D
E
S
K
A
A
T
L
S
D
Q
E
I
L
N
F
L
F
V
P
G
F
S
------------
V
G
M
D
V
V
K
N
V
V
E
S
L
N
G
S
I
S
I
E
S
E
K
D
K
G
T
K
V
T
I
R
L
P
L
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
53.74
54%
-42
- C3 -
1I5A
2
CHEA_THEMA
A:
[2-189]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
H
M
V
P
I
S
F
V
F
N
R
F
P
R
M
V
R
D
L
A
K
K
M
N
K
E
V
N
F
I
M
R
G
E
D
T
E
L
D
R
T
F
V
E
E
I
G
E
P
L
L
H
L
L
R
N
A
I
D
H
G
I
E
P
K
E
E
R
I
A
K
G
K
P
P
I
G
T
L
I
L
S
A
R
H
E
G
N
N
V
V
I
E
V
E
D
D
G
R
G
I
D
K
E
K
I
I
R
K
A
I
E
K
G
L
I
D
E
S
K
A
A
T
L
S
D
Q
E
I
L
N
F
L
F
V
P
G
F
S
T
K
E
--------
G
V
G
M
D
V
V
K
N
V
V
E
S
L
N
G
S
I
S
I
E
S
E
K
D
K
G
T
K
V
T
I
R
L
P
L
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
53.70
54%
-47
- C3 -
1I59
3
CHEA_THEMA
A:
[2-189]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
H
M
V
P
I
S
F
V
F
N
R
F
P
R
M
V
R
D
L
A
K
K
M
N
K
E
V
N
F
I
M
R
G
E
D
T
E
L
D
R
T
F
V
E
E
I
G
E
P
L
L
H
L
L
R
N
A
I
D
H
G
I
E
P
K
E
E
R
I
A
K
G
K
P
P
I
G
T
L
I
L
S
A
R
H
E
G
N
N
V
V
I
E
V
E
D
D
G
R
G
I
D
K
E
K
I
I
R
K
A
I
E
K
G
L
I
D
E
S
K
A
A
T
L
S
D
Q
E
I
L
N
F
L
F
V
P
G
F
S
T
K
--------
R
G
V
G
M
D
V
V
K
N
V
V
E
S
L
N
G
S
I
S
I
E
S
E
K
D
K
G
T
K
V
T
I
R
L
P
L
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
53.51
54%
-39
- C3 -
1I5A
2
B:
[2-189]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
H
M
V
P
I
S
F
V
F
N
R
F
P
R
M
V
R
D
L
A
K
K
M
N
K
E
V
N
F
I
M
R
G
E
D
T
E
L
D
R
T
F
V
E
E
I
G
E
P
L
L
H
L
L
R
N
A
I
D
H
G
I
E
P
K
E
E
R
I
A
K
G
K
P
P
I
G
T
L
I
L
S
A
R
H
E
G
N
N
V
V
I
E
V
E
D
D
G
R
G
I
D
K
E
K
I
I
R
K
A
I
E
K
G
L
I
D
E
S
K
A
A
T
L
S
D
Q
E
I
L
N
F
L
F
V
P
G
F
S
T
-----------
V
G
M
D
V
V
K
N
V
V
E
S
L
N
G
S
I
S
I
E
S
E
K
D
K
G
T
K
V
T
I
R
L
P
L
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
53.16
54%
-35
- C3 -
1I59
1
B:
[2-189]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
H
M
V
P
I
S
F
V
F
N
R
F
P
R
M
V
R
D
L
A
K
K
M
N
K
E
V
N
F
I
M
R
G
E
D
T
E
L
D
R
T
F
V
E
E
I
G
E
P
L
L
H
L
L
R
N
A
I
D
H
G
I
E
P
K
E
E
R
I
A
K
G
K
P
P
I
G
T
L
I
L
S
A
R
H
E
G
N
N
V
V
I
E
V
E
D
D
G
R
G
I
D
K
E
K
I
I
R
K
A
I
E
K
G
L
I
D
E
S
K
A
A
T
L
S
D
Q
E
I
L
N
F
L
F
V
P
G
F
S
T
K
E
K
V
S
E
V
S
G
R
G
V
G
M
D
V
V
K
N
V
V
E
S
L
N
G
S
I
S
I
E
S
E
K
D
K
G
T
K
V
T
I
R
L
P
L
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
126
Fugue
52.74
53%
-54
- C3 -
1B3Q
-
CHEA_THEMA
A:
[63-248]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
V
P
I
S
F
V
F
N
R
F
P
R
M
V
R
D
L
A
K
K
M
N
K
E
V
N
F
I
M
R
G
E
D
T
E
L
D
R
T
F
V
E
E
I
G
E
P
L
L
H
L
L
R
N
A
I
D
H
G
I
E
P
K
E
E
R
I
A
K
G
K
P
P
I
G
T
L
I
L
S
A
R
H
E
G
N
N
V
V
I
E
V
E
D
D
G
R
G
I
D
K
E
K
I
I
R
K
A
I
E
K
G
L
I
D
E
S
K
A
A
T
L
S
D
Q
E
I
L
N
F
L
F
V
P
G
F
S
-----------
G
V
G
M
D
V
V
K
N
V
V
E
S
L
N
G
S
M
G
I
E
S
E
K
D
K
G
T
K
V
T
I
R
L
P
L
T
L
A
I
I
C
A
L
L
V
K
V
N
N
L
V
Y
A
I
P
I
A
N
I
D
T
I
L
S
I
S
K
E
D
I
Q
R
V
Q
D
R
D
V
I
V
I
R
G
E
V
I
P
V
Y
R
L
W
E
V
L
Q
I
E
H
K
E
E
L
E
E
M
E
A
V
I
V
R
V
G
N
R
K
Y
G
I
V
V
D
D
L
L
G
Q
D
D
I
V
I
K
S
L
G
K
V
F
S
E
V
K
E
F
S
G
A
A
I
L
G
D
G
S
I
A
L
I
I
N
V
S
G
I
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------
107
HHSearch
51.96
55%
-43
- C3 -
1I58
3
CHEA_THEMA
A:
[3-189]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
M
V
P
I
S
F
V
F
N
R
F
P
R
M
V
R
D
L
A
K
K
M
N
K
E
V
N
F
I
M
R
G
E
D
T
E
L
D
R
T
F
V
E
E
I
G
E
P
L
L
H
L
L
R
N
A
I
D
H
G
I
E
P
K
E
E
R
I
A
K
G
K
P
P
I
G
T
L
I
L
S
A
R
H
E
G
N
N
V
V
I
E
V
E
D
D
G
R
G
I
D
K
E
K
I
I
R
K
A
I
E
K
G
L
I
D
E
S
K
A
A
T
L
S
D
Q
E
I
L
N
F
L
F
V
P
G
F
S
T
K
E
K
V
S
E
V
S
G
R
G
V
G
M
D
V
V
K
N
V
V
E
S
L
N
G
S
I
S
I
E
S
E
K
D
K
G
T
K
V
T
I
R
L
P
L
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
125
Fugue
51.31
53%
-43
- C3 -
1I58
3
CHEA_THEMA
A:
[1-189]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
H
M
V
P
I
S
F
V
F
N
R
F
P
R
M
V
R
D
L
A
K
K
M
N
K
E
V
N
F
I
M
R
G
E
D
T
E
L
D
R
T
F
V
E
E
I
G
E
P
L
L
H
L
L
R
N
A
I
D
H
G
I
E
P
K
E
E
R
I
A
K
G
K
P
P
I
G
T
L
I
L
S
A
R
H
E
G
N
N
V
V
I
E
V
E
D
D
G
R
G
I
D
K
E
K
I
I
R
K
A
I
E
K
G
L
I
D
E
S
K
A
A
T
L
S
D
Q
E
I
L
N
F
L
F
V
P
G
F
S
T
K
E
K
V
S
E
V
S
G
R
G
V
G
M
D
V
V
K
N
V
V
E
S
L
N
G
S
I
S
I
E
S
E
K
D
K
G
T
K
V
T
I
R
L
P
L
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
50.87
54%
-43
- C3 -
1I58
3
CHEA_THEMA
A:
[2-189]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
H
M
V
P
I
S
F
V
F
N
R
F
P
R
M
V
R
D
L
A
K
K
M
N
K
E
V
N
F
I
M
R
G
E
D
T
E
L
D
R
T
F
V
E
E
I
G
E
P
L
L
H
L
L
R
N
A
I
D
H
G
I
E
P
K
E
E
R
I
A
K
G
K
P
P
I
G
T
L
I
L
S
A
R
H
E
G
N
N
V
V
I
E
V
E
D
D
G
R
G
I
D
K
E
K
I
I
R
K
A
I
E
K
G
L
I
D
E
S
K
A
A
T
L
S
D
Q
E
I
L
N
F
L
F
V
P
G
F
S
T
K
E
K
V
S
E
V
S
G
R
G
V
G
M
D
V
V
K
N
V
V
E
S
L
N
G
S
I
S
I
E
S
E
K
D
K
G
T
K
V
T
I
R
L
P
L
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
49.97
33%
-48
- C4 -
3TO5
1
?
A:
[15-123]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
L
I
V
D
D
F
S
T
M
R
R
I
V
K
N
L
L
R
D
L
G
F
N
N
T
Q
E
A
D
D
G
L
T
A
L
P
M
L
K
K
G
D
F
--
D
F
V
V
T
D
W
N
M
P
G
M
Q
G
I
D
L
L
K
N
I
R
A
D
E
E
L
K
H
L
P
V
L
M
I
T
A
E
A
K
R
E
Q
I
I
E
A
A
Q
A
G
V
N
G
Y
I
V
K
P
F
T
A
A
T
L
K
E
K
L
D
K
I
F
E
------
5
PsiBlast_PDB
49.48
55%
-48
- C3 -
1I5D
3
A:
[1-190]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
M
K
I
R
M
V
P
I
S
F
V
F
N
R
F
P
R
M
V
R
D
L
A
K
K
M
N
K
E
V
N
F
I
M
R
G
E
D
T
E
L
D
R
T
F
V
E
E
I
G
E
P
L
L
H
L
L
R
N
A
I
D
H
G
I
E
P
K
E
E
R
I
A
K
G
K
P
P
I
G
T
L
I
L
S
A
R
H
E
G
N
N
V
V
I
E
V
E
D
D
G
R
G
I
D
K
E
K
I
I
R
K
A
I
E
K
G
L
I
D
E
S
K
A
A
T
L
S
D
Q
E
I
L
N
F
L
F
V
P
G
F
S
T
K
E
K
V
S
E
V
S
G
R
G
V
G
M
D
V
V
K
N
V
V
E
S
L
N
G
S
I
S
I
E
S
E
K
D
K
G
T
K
V
T
I
R
L
P
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------