@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_1000: (2015-12-20 )
MTLSQALNKAKKELSPKGFRGGLESEILLGFVLQKERVFLHTHEHLELSHEEETRFFELVGKRLNDCPIEYLLGSCDFYGRSFFVNEHVLIPRPETEILVQKALNIISQYHLKEIGEIGIGSGCVSVSLALENPNLSIYASDISPKALEVALKNIERFCLKERVFLKQTRLWDHMPTIEMLVSNPPYIARNYPLEKSVLKEPHEALFGGVKGDEILKEIVFLAAKLKIPFLVCEMGYDQLKSLKECLEFCGYDAEFYKDLSGFDRGFVGVLKSFLR
Atome Classification :
(20 SA)
-----------------------------------------------------------------------------------.........10........20........30........40.......---.50........60......-..70........80........90..-------------------......100..------...------..110-.....--------..120.......130...--....140.......150......--------.160......---.170----...---------.--.----.--.180...--....190-..-.....-.200........210.......220-----...--.--...--230.--------......-240.......250-..-.......260--........270....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-----------------------------------------------------------------------------------M
T
L
S
Q
A
L
N
K
A
K
K
ELS
P
K
GFRGGL
E
S
E
I
L
L
G
F
V
L
QK
E
R
V
F
L
H
THEHLEL---S
H
E
E
E
T
R
F
F
E
L
V
G
K
R
L
NDC-
P
I
E
Y
L
L
GSCDFYG
R
S
F
F
VNE
H
V
LIPR-------------------P
E
T
E
I
L
V
Q
K
A
L
------
N
I
I
------
S
Q
Y
H
L
-
K
E
I
GE--------IGIGS
G
C
V
S
V
S
L
A
LENP
N
--
L
S
I
Y
ASDIS
P
K
A
L
E
V
A
L
K
N
I
E
R
F
--------
C
L
K
E
R
V
F
L
K
Q
---
T
R
L
W----DHM---------P--
T
----
I
--
E
M
L
VSNP--PYIARN--YP-L
E
K
S
V
-
L
K-E
P
H
E
A
L
FGGV
K
G
D
E
I
L
K
E
I
V
F
L
-----
A
A
K--L--K
I
P
--
F
L
V
C--------EM
G
Y
D
Q
-
L
K
S
L
K
E
C
L
E
F
C---GY-
D
A
E
F
Y
K
D
L
-
S
--GF
D
R
G
F
V
G
V
L
K
S
FLR
41
HHSearch
89.96
36%
-97
- C1 -
1NV8
2
PRMC_THEMA
A:
[14-283]
-----------------------------------------------------------------------------------
R
K
I
W
S
L
I
R
D
C
S
G
K
L
E
G
V
T
E
T
S
V
L
E
V
L
L
I
V
S
R
V
L
G
I
R
K
E
D
L
F
L
K
-
D
L
G
V
---
S
P
T
E
E
K
R
I
L
E
L
V
E
K
R
A
S
G
Y
-
P
L
H
Y
I
L
G
E
K
E
F
M
G
L
S
F
L
V
E
E
G
V
F
V
P
R
-------------------
P
E
T
E
E
L
V
E
L
A
L
------
E
L
I
------
R
K
Y
G
I
-
K
T
V
A
D
--------
I
G
T
G
S
G
A
I
G
V
S
V
A
K
F
-
S
D
--
A
I
V
F
A
T
D
V
S
S
K
A
V
E
I
A
R
K
N
A
E
R
H
--------
G
V
S
D
R
F
F
V
R
K
---
G
E
F
L
----
E
P
F
KEKF-----
A
--
S
----
I
--
E
M
I
L
S
N
P
--
P
Y
V
K
S
S
--
A
H
-
L
P
K
D
V
-
L
F
-
E
P
P
E
A
L
F
G
G
E
D
G
L
D
F
Y
R
E
F
F
G
R
-----
Y
----
D
--
T
S
G
K
-
I
V
L
M
--------
E
I
G
E
D
Q
-
V
E
E
L
K
K
I
V
S
D
--------
T
V
F
L
K
D
S
-
A
--
G
K
Y
R
F
L
L
L
N
R
R
S
S
--
31
Fugue
89.85
35%
-90
- C1 -
1NV9
1
PRMC_THEMA
A:
[15-284]
------------------------------------------------------------------------------------
K
I
W
S
L
I
R
D
C
S
G
K
L
E
G
V
T
E
T
S
V
L
E
V
L
L
I
V
S
R
V
L
G
I
R
K
E
D
L
F
L
K
D
L
-
G
V
---
S
P
T
E
E
K
R
I
L
E
L
V
E
K
R
A
S
G
Y
-
P
L
H
Y
I
L
G
E
K
E
F
M
G
L
S
F
L
V
E
E
G
V
F
V
P
R
-------------------
P
E
T
E
E
L
V
E
L
A
L
------
E
L
I
------
R
K
Y
G
I
-
K
T
V
A
D
--------
I
G
T
G
S
G
A
I
G
V
S
V
A
K
F
-
S
D
--
A
I
V
F
A
T
D
V
S
S
K
A
V
E
I
A
R
K
N
A
E
R
H
--------
G
V
S
D
R
F
F
V
R
K
---
G
E
F
L
----
E
P
F
---------
K
--
E
KFAS
I
--
E
M
I
L
S
N
P
--
P
Y
V
---------
K
S
S
A
-
L
F
-
E
P
P
E
A
L
F
G
G
E
D
G
L
D
F
Y
R
E
F
F
G
R
-----
Y
D
T
--
S
--
G
-
K
--
I
V
L
M
--------
E
I
G
E
D
Q
-
V
E
E
L
K
K
I
V
S
--------
D
T
V
F
L
K
D
S
-
A
--
G
K
Y
R
F
L
L
L
N
R
R
S
S
--
42
HHSearch
88.18
29%
-87
- C1 -
2B3T
1
PRMC_ECOLI
A:
[1-275]
-----------------------------------------------------------------------------------
M
E
Y
Q
H
W
L
R
E
A
I
S
Q
L
Q
A
S
E
-
S
P
R
R
D
A
E
I
L
L
E
H
V
T
G
R
G
R
T
F
I
L
A
F
G
E
T
Q
L
---
T
D
E
Q
C
Q
Q
L
D
A
L
L
T
R
R
R
D
G
E
-
P
I
A
H
L
T
G
V
R
E
F
W
S
L
P
L
F
V
S
P
A
T
L
I
P
R
-------------------
P
D
T
E
C
L
V
E
Q
A
L
------
A
R
L
------
P
E
-
Q
P
-
C
R
I
L
D
--------
L
G
T
G
T
G
A
I
A
L
A
L
A
S
E
R
P
D
--
C
E
I
I
A
V
D
R
M
P
D
A
V
S
L
A
Q
R
N
A
Q
H
L
--------
A
I
K
-
N
I
H
I
L
Q
---
S
D
W
F
----
S
A
L
A
G
-------
Q
--
Q
----
F
--
A
M
I
V
S
N
P
--
P
Y
I
D
E
Q
--
D
P
H
L
Q
Q
G
D
V
R
F
-
E
P
L
T
A
L
V
A
A
D
S
G
M
A
D
I
V
H
I
I
E
Q
-----
S
R
N
A
L
V
--
S
G
G
--
F
L
L
L
--------
E
H
G
W
Q
Q
-
G
E
A
V
R
Q
A
F
I
L
A
---
G
Y
H
D
V
E
T
C
R
D
Y
-
G
--
D
N
E
R
V
T
L
G
R
Y
Y
----
23
PsiBlast_CBE
83.63
39%
-103
- C1 -
1NV8
2
PRMC_THEMA
B:
[48-272]
-------------------------------------------------------------------------------------------------------------------
I
R
K
E
D
L
F
L
-----
L
G
V
---
S
P
T
E
E
K
R
I
L
E
L
V
E
K
R
A
S
G
Y
-
P
L
H
Y
I
L
G
E
K
E
F
M
G
L
S
F
L
V
E
E
G
V
F
V
P
R
-------------------
P
E
T
E
E
L
V
E
L
A
L
------
E
L
I
------
R
K
Y
G
I
-
K
T
V
A
D
--------
I
G
T
G
S
G
A
I
G
V
S
V
A
-
K
F
S
D
--
A
I
V
F
A
T
D
V
S
S
K
A
V
E
I
A
R
K
N
A
E
R
H
--------
G
V
S
D
R
F
F
V
R
K
---
G
E
F
L
EPFK
E
K
F
---------
A
--
S
----
I
--
E
M
I
L
S
N
P
--
P
Y
V
K
S
S
--
A
H
-
L
P
K
D
V
-
L
F
-
E
P
P
E
A
L
F
G
G
E
D
G
L
D
F
Y
R
E
F
-
F
G
-----
R
Y
D
--
T
--
S
G
K
--
I
V
L
M
--------
E
I
G
E
D
Q
-
V
E
E
L
K
K
I
V
S
--------
D
T
V
F
L
K
D
S
-
A
--
G
K
Y
R
F
L
L
L
N
R
R
S
---
22
PsiBlast_CBE
83.56
39%
-98
- C1 -
1SG9
2
PRMC_THEMA
B:
[46-270]
-------------------------------------------------------------------------------------------------------------------
I
R
K
E
D
L
F
L
---
K
D
L
G
V
---
S
P
T
E
E
K
R
I
L
E
L
V
E
K
R
A
S
G
Y
-
P
L
H
Y
I
L
G
E
K
E
F
M
G
L
S
F
L
V
E
E
G
V
F
V
P
R
-------------------
P
E
T
E
E
L
V
E
L
A
L
------
E
L
I
------
R
K
Y
G
I
-
K
T
V
A
D
--------
I
G
T
G
S
G
A
I
G
V
S
V
A
-
K
F
S
D
--
A
I
V
F
A
T
D
V
S
S
K
A
V
E
I
A
R
K
N
A
E
R
H
--------
G
V
S
D
R
F
F
V
R
K
---
G
E
F
L
EPFK
E
K
F
---------
A
--
S
----
I
--
E
M
I
L
S
N
P
--
P
Y
V
K
S
S
--
A
H
-
L
P
K
D
V
-
L
F
-
E
P
P
E
A
L
F
G
G
E
D
G
L
D
F
Y
R
E
F
-
F
G
-----
R
Y
D
--
T
--
S
G
K
--
I
V
L
M
--------
E
I
G
E
D
Q
-
V
E
E
L
K
K
I
V
S
--------
D
T
V
F
L
K
D
S
-
A
--
G
K
Y
R
F
L
L
L
N
R
R
S
---
5
PsiBlast_PDB
83.54
29%
-88
- C1 -
2B3T
1
PRMC_ECOLI
A:
[7-273]
-------------------------------------------------------------------------------------
L
R
E
A
I
S
Q
L
Q
A
S
E
S
P
R
-----
R
D
A
E
I
L
L
E
H
V
T
G
R
G
R
T
F
I
L
A
F
G
E
T
Q
L
---
T
D
E
Q
C
Q
Q
L
D
A
L
L
T
R
R
R
D
G
E
-
P
I
A
H
L
T
G
V
R
E
F
W
S
L
P
L
F
V
S
P
A
T
L
I
P
R
-------------------
P
D
T
E
C
L
V
E
Q
A
L
------
A
R
L
------
P
E
Q
P
C
-
R
-
I
L
D
--------
L
G
T
G
T
G
A
I
A
L
A
L
A
S
E
R
P
D
--
C
E
I
I
A
V
D
R
M
P
D
A
V
S
L
A
Q
R
N
A
Q
H
L
--------
A
I
K
N
-
I
H
I
L
Q
---
S
D
W
F
----
S
A
L
---------
A
G
Q
Q
----
F
--
A
M
I
V
S
N
P
--
P
Y
I
D
E
Q
--
D
P
H
L
Q
Q
G
D
-
V
R
F
E
P
L
T
A
L
---
V
A
A
D
S
G
M
A
D
I
V
H
I
I
E
Q
S
R
N
A
L
--
V
--
S
G
G
--
F
L
L
L
--------
E
H
G
W
Q
Q
-
G
E
A
V
R
Q
A
F
I
L
A
---
G
Y
H
D
V
E
T
C
R
D
Y
-
G
--
D
N
E
R
V
T
L
G
R
Y
Y
----
2
PsiBlast_PDB
82.58
39%
-100
- C1 -
1NV9
1
PRMC_THEMA
A:
[48-272]
-------------------------------------------------------------------------------------------------------------------
I
R
K
E
D
L
F
L
---
K
D
L
G
V
---
S
P
T
E
E
K
R
I
L
E
L
V
E
K
R
A
S
G
Y
-
P
L
H
Y
I
L
G
E
K
E
F
M
G
L
S
F
L
V
E
E
G
V
F
V
P
R
-------------------
P
E
T
E
E
L
V
E
L
A
L
------
E
L
I
------
R
K
Y
G
I
-
K
T
V
A
D
--------
I
G
T
G
S
G
A
I
G
V
S
V
A
-
K
F
S
D
--
A
I
V
F
A
T
D
V
S
S
K
A
V
E
I
A
R
K
N
A
E
R
H
--------
G
V
S
D
R
F
F
V
R
K
---
G
E
F
L
EPFK
E
K
F
---------
A
--
S
----
I
--
E
M
I
L
S
N
P
--
P
Y
V
K
S
S
--
A
--------
L
F
-
E
P
P
E
A
L
F
G
G
E
D
G
L
D
F
Y
R
E
F
-
F
G
-----
R
Y
D
--
T
--
S
G
K
--
I
V
L
M
--------
E
I
G
E
D
Q
-
V
E
E
L
K
K
I
V
S
--------
D
T
V
F
L
K
D
S
-
A
--
G
K
Y
R
F
L
L
L
N
R
R
S
S
--
32
Fugue
82.45
28%
-90
* C1 *
1T43
1
PRMC_ECOLI
A:
[2-275]
------------------------------------------------------------------------------------
E
Y
Q
H
W
L
R
E
A
I
S
Q
L
Q
A
S
E
-
S
P
R
R
D
A
E
I
L
L
E
H
V
T
G
R
G
R
T
F
I
L
A
F
G
E
T
Q
L
---
T
D
E
Q
C
Q
Q
L
D
A
L
L
T
R
R
R
D
G
E
-
P
I
A
H
L
T
G
V
R
E
F
W
S
L
P
L
F
V
S
P
A
T
L
I
P
R
-------------------
P
D
T
E
C
L
V
E
Q
A
L
------
A
R
L
------
P
E
Q
P
C
-
R
-
I
L
D
--------
L
G
T
G
T
G
A
I
A
L
A
L
A
S
E
R
P
D
--
C
E
I
I
A
V
D
R
M
P
D
A
V
S
L
A
Q
R
N
A
Q
H
L
--------
A
I
K
N
I
H
I
L
Q
S
---
D
W
F
S
----
A
L
A
---------
G
Q-
Q
----
F
--
A
M
I
V
S
N
P
--
P
Y
I
D
E
Q
DP
H
L
-
Q
Q
G
D
V
-
R
F
-
E
P
L
T
A
L
V
A
A
D
S
G
M
A
D
I
V
H
I
I
E
Q
-----
S
R
N
--
A
--
L
V
S
G
G
F
L
L
L
--------
E
H
G
W
Q
Q
-
G
E
A
V
R
Q
A
F
I
L
A
---
G
Y
H
D
V
E
T
C
R
D
Y
-
G
--
D
N
E
R
V
T
L
G
R
Y
-----
4
PsiBlast_PDB
82.00
39%
-96
- C1 -
1VQ1
1
PRMC_THEMA
A:
[58-282]
-------------------------------------------------------------------------------------------------------------------
I
R
K
E
D
L
F
L
---
K
D
L
G
V
---
S
P
T
E
E
K
R
I
L
E
L
V
E
K
R
A
S
G
Y
-
P
L
H
Y
I
L
G
E
K
E
F
M
G
L
S
F
L
V
E
E
G
V
F
V
P
R
-------------------
P
E
T
E
E
L
V
E
L
A
L
------
E
L
I
------
R
K
Y
G
I
-
K
T
V
A
D
--------
I
G
T
G
S
G
A
I
G
V
S
V
A
-
K
F
S
D
--
A
I
V
F
A
T
D
V
S
S
K
A
V
E
I
A
R
K
N
A
E
R
H
--------
G
V
S
D
R
F
F
V
R
K
---
G
E
F
L
EPFK
E
K
F
---------
A
--
S
----
I
--
E
M
I
L
S
N
P
--
P
Y
V
K
S
S
--
A
H
-
L
------
F
-
E
P
P
E
A
L
F
G
G
E
D
G
L
D
F
Y
R
E
F
-
F
G
-----
R
Y
D
--
T
--
S
G
K
--
I
V
L
M
--------
E
I
G
E
D
Q
-
V
E
E
L
K
K
I
V
S
--------
D
T
V
F
L
K
D
S
-
A
--
G
K
Y
R
F
L
L
L
N
R
R
S
S
--
21
PsiBlast_CBE
81.98
39%
-95
- C1 -
1SG9
2
PRMC_THEMA
C:
[46-270]
-------------------------------------------------------------------------------------------------------------------
I
R
K
E
D
L
F
L
---
K
D
L
G
V
---
S
P
T
E
E
K
R
I
L
E
L
V
E
K
R
A
S
G
Y
-
P
L
H
Y
I
L
G
E
K
E
F
M
G
L
S
F
L
V
E
E
G
V
F
V
P
R
-------------------
P
E
T
E
E
L
V
E
L
A
L
------
E
L
I
------
R
K
Y
G
I
-
K
T
V
A
D
--------
I
G
T
G
S
G
A
I
G
V
S
V
A
-
K
F
S
D
--
A
I
V
F
A
T
D
V
S
S
K
A
V
E
I
A
R
K
N
A
E
R
H
--------
G
V
S
D
R
F
F
V
R
K
---
G
E
F
L
EPFK
E
K
F
---------
A
--
S
----
I
--
E
M
I
L
S
N
P
--
P
Y
V
K
S
S
--
A
H
-
L
P
K
D
V
-
L
F
-
E
P
P
E
A
L
F
G
G
E
D
G
L
D
F
Y
R
E
F
-
F
G
-----
R
Y
D
--
T
--
S
G
K
--
I
V
L
M
--------
E
I
G
E
D
Q
-
V
E
E
L
K
K
I
V
S
--------
D
T
V
F
L
K
D
S
-
A
--
G
K
Y
R
F
L
L
L
N
R
R
S
---
6
PsiBlast_PDB
81.86
29%
-94
- C1 -
1T43
1
PRMC_ECOLI
A:
[7-273]
-------------------------------------------------------------------------------------
L
R
E
A
I
S
Q
L
Q
A
S
E
S
P
R
-----
R
D
A
E
I
L
L
E
H
V
T
G
R
G
R
T
F
I
L
A
F
G
E
T
Q
L
---
T
D
E
Q
C
Q
Q
L
D
A
L
L
T
R
R
R
D
G
E
-
P
I
A
H
L
T
G
V
R
E
F
W
S
L
P
L
F
V
S
P
A
T
L
I
P
R
-------------------
P
D
T
E
C
L
V
E
Q
A
L
------
A
R
L
------
P
E
Q
P
C
-
R
-
I
L
D
--------
L
G
T
G
T
G
A
I
A
L
A
L
A
S
E
R
P
D
--
C
E
I
I
A
V
D
R
M
P
D
A
V
S
L
A
Q
R
N
A
Q
H
L
--------
A
I
K
N
-
I
H
I
L
Q
---
S
D
W
F
----
S
A
L
---------
A
GQ
Q
----
F
--
A
M
I
V
S
N
P
--
P
Y
I
D
E
Q
--
D
P
H
L
Q
Q
G
D
-
V
R
F
E
P
L
T
A
L
---
V
A
A
D
S
G
M
A
D
I
V
H
I
I
E
Q
S
R
N
A
L
--
V
--
S
G
G
--
F
L
L
L
--------
E
H
G
W
Q
Q
-
G
E
A
V
R
Q
A
F
I
L
A
---
G
Y
H
D
V
E
T
C
R
D
Y
-
G
--
D
N
E
R
V
T
L
G
R
Y
-----
1
PsiBlast_PDB
81.52
39%
-98
- C1 -
1NV8
2
PRMC_THEMA
A:
[48-272]
-------------------------------------------------------------------------------------------------------------------
I
R
K
E
D
L
F
L
---
K
D
L
G
V
---
S
P
T
E
E
K
R
I
L
E
L
V
E
K
R
A
S
G
Y
-
P
L
H
Y
I
L
G
E
K
E
F
M
G
L
S
F
L
V
E
E
G
V
F
V
P
R
-------------------
P
E
T
E
E
L
V
E
L
A
L
------
E
L
I
------
R
K
Y
G
I
-
K
T
V
A
D
--------
I
G
T
G
S
G
A
I
G
V
S
V
A
-
K
F
S
D
--
A
I
V
F
A
T
D
V
S
S
K
A
V
E
I
A
R
K
N
A
E
R
H
--------
G
V
S
D
R
F
F
V
R
K
---
G
E
F
L
EPFK
E
K
F
---------
A
--
S
----
I
--
E
M
I
L
S
N
P
--
P
Y
V
K
S
S
--
A
H
-
L
P
K
D
V
-
L
F
-
E
P
P
E
A
L
F
G
G
E
D
G
L
D
F
Y
R
E
F
-
F
G
-----
R
Y
D
--
T
--
S
G
K
--
I
V
L
M
--------
E
I
G
E
D
Q
-
V
E
E
L
K
K
I
V
S
--------
D
T
V
F
L
K
D
S
-
A
--
G
K
Y
R
F
L
L
L
N
R
R
S
S
--
3
PsiBlast_PDB
81.50
39%
-98
- C1 -
1SG9
2
PRMC_THEMA
A:
[46-270]
-------------------------------------------------------------------------------------------------------------------
I
R
K
E
D
L
F
L
---
K
D
L
G
V
---
S
P
T
E
E
K
R
I
L
E
L
V
E
K
R
A
S
G
Y
-
P
L
H
Y
I
L
G
E
K
E
F
M
G
L
S
F
L
V
E
E
G
V
F
V
P
R
-------------------
P
E
T
E
E
L
V
E
L
A
L
------
E
L
I
------
R
K
Y
G
I
-
K
T
V
A
D
--------
I
G
T
G
S
G
A
I
G
V
S
V
A
-
K
F
S
D
--
A
I
V
F
A
T
D
V
S
S
K
A
V
E
I
A
R
K
N
A
E
R
H
--------
G
V
S
D
R
F
F
V
R
K
---
G
E
F
L
EPFK
E
K
F
---------
A
--
S
----
I
--
E
M
I
L
S
N
P
--
P
Y
V
K
S
S
--
A
H
-
L
P
K
D
V
-
L
F
-
E
P
P
E
A
L
F
G
G
E
D
G
L
D
F
Y
R
E
F
-
F
G
-----
R
Y
D
--
T
--
S
G
K
--
I
V
L
M
--------
E
I
G
E
D
Q
-
V
E
E
L
K
K
I
V
S
--------
D
T
V
F
L
K
D
S
-
A
--
G
K
Y
R
F
L
L
L
N
R
R
S
---
33
Fugue
65.71
18%
-80
- C1 -
2H00
2
MET16_HUMAN
A:
[5-254]
-----------------------------------------------------------------------------------
V
S
L
N
F
K
D
P
E
A
V
R
A
L
T
C
T
L
L
R
E
D
F
------------------------------------------------------------
G
L
S
I
D
I
P
L
E
R
L
I
P
T
-------------------
V
P
L
R
L
N
Y
I
H
W
V
------
E
D
L
I
G
H
Q
D
S
D
K
S
T
L
-
R
R
G
I
D
--------
I
G
T
G
A
S
C
I
Y
P
L
L
G
A
T
L
N
G
--
W
Y
F
L
A
T
E
V
D
D
M
C
F
N
Y
A
K
K
N
V
E
Q
N
--------
N
L
S
D
L
I
K
V
V
K
---
V
P
Q
K
----
T
L
L
M
D
A
L
KEESE
I
--
I
----
Y
--
D
F
C
M
C
N
P
--
P
F
F
G
I
T
--
E
I
-
M
A
E
G
---------------
G
E
L
E
F
V
K
R
I
I
H
D
-----
S
L
Q
--
L
KK
R
L
R
--
W
Y
S
C
--------
M
L
G
K
K
C
S
L
A
P
L
K
E
E
L
R
I
Q
---
G
V
-
P
K
V
T
Y
T
E
F
-
C
--
Q
G
R
T
M
R
W
A
L
A
W
S
F
Y
D
7
PsiBlast_PDB
61.57
32%
-93
- C1 -
4DZR
3
?
A:
[1-198]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
V
G
P
D
C
L
I
P
R
-------------------
P
D
T
E
V
L
V
E
E
A
I
------
R
F
L
------
K
R
M
P
S
G
T
R
V
I
D
--------
V
G
T
G
S
G
C
I
A
V
S
I
A
L
A
C
P
G
--
V
S
V
T
A
V
D
L
S
--------------WA
A
A
D
G
I
E
W
L
I
E
R
A
--
E
R
---
G
R
P
W
---------------------------
H
A
I
V
S
N
P
--
P
Y
I
P
--------------------------
D
G
L
Q
F
Y
R
R
M
A
A
L
-----
P
---------
P
--
Y
V
L
A
R
G
R
A
G
V
F
L
E
V
G
H
N
Q
-
A
D
E
V
A
R
L
F
A
P
W
RER
G
F
-
R
V
R
K
V
K
D
L
-
R
--
G
I
D
R
V
I
A
V
T
R
E
P
---
37
Fugue
60.52
16%
-78
- C1 -
3TM4
1
?
A:
[1-370]
M
K
F
L
L
T
T
A
QGI
E
D
I
A
K
R
E
V
S
L
L
L
K
K
L
G
I
S
F
Q
I
E
E
KPLGIEG
R
L
L
L
E
A
E
K
A
Y
Y
V
D
EKG
R
K
R
E
L
S
I
S
T
Y
L
N
E
N
SRLLH
R
V
I
I
E
I
A
S
E
K
F
N
G
I
E
K
D
E
S
E
E
A
L
K
R
I
K
D
F
V
S
S
L
P
V
E
Q
F
V
K
V
S
E
T
F
A
V
R
S
F
R
K
G
D
H
NIT
S
I
D
I
A
R
T
V
G
E
A
I
F
E
R
L
S
R
F
G
T
P
L
V
N
L
D
H
P
A
V
I
F
R
A
E
L
I
K
D
V
F
F
L
G
I
DTTGDSSLHKRPWRVYDHP
A
H
L
K
A
S
I
A
N
A
M
------
I
E
L
------
A
E
L
D
G
-
G
S
V
L
D
--------
P
M
C
G
S
G
T
I
L
I
E
L
A
L
R
R
Y
S
--
G
E
I
I
G
I
E
K
Y
R
K
H
L
I
G
A
E
M
N
A
L
A
A
--------
G
V
L
D
K
I
K
F
I
Q
GDA
T
Q
L
S
----
Q
Y
V
---------
D
--
S
----
V
--
D
F
A
I
S
N
L
--
P
Y
G
S
M
I
--
P
D
-
L
Y
M
K
F
-
F
N
-
E
L
A
K
V
---------
L
E
K
R
G
V
F
I
-----
T
----------------------------
T
E
-
K
K
A
I
E
E
A
I
A
E
N
---
G
F
-
E
I
I
H
H
R
V
I
-
G
H
G
G
L
M
V
H
L
Y
V
V
K
L
E
H
H
H
36
Fugue
60.34
17%
-80
- C1 -
3GDH
3
TGS1_HUMAN
B:
[25-235]
-------------------------------------------------------------------------------------------------------
E
I
A
A
V
P
E
L
A
K
Y
W
A
Q
R
Y
R
L
F
S
R
F
D
D
G
I
K
L
---
D
---
R
E
G
W
F
S
V
T
P
E
K
I
A
E
H
-
I
A
G
R
V
S
Q
S
C
D
V
V
V
D
A
F
----------------------------------------------------------------------------
C
G
V
G
G
N
T
I
Q
F
A
L
T
G
M
----
R
V
I
A
I
D
I
D
P
V
K
I
A
L
A
R
N
N
A
E
V
Y
--------
G
I
A
D
K
I
E
F
I
C
---
G
D
F
L
----
L
L
A
---------
S
--
F
----
L
KA
D
V
V
F
L
S
P
--
P
W
G
G
P
D
--
Y
A
-
T
A
E
T
F
-
D
I
-
R
T
M
M
S
----
P
D
G
F
E
I
F
R
L
S
K
K
I
-----
T
N
N
--
I
---
V
Y
--
F
L
P
R
--------
N
A
D
I
D
Q
-
V
A
S
L
A
G
P
-------
G
G
-
Q
V
E
I
E
Q
N
F
L
N
--
N
K
L
K
T
I
T
A
Y
F
G
D
L
I
R
29
PsiBlast_CBE
57.67
32%
-83
- C1 -
3HTX
3
HEN1_ARATH
D:
[704-784]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
L
S
K
Q
R
V
E
Y
A
L
------
K
H
I
------
R
E
S
S
A
-
S
T
L
V
D
--------
F
G
C
G
S
G
S
L
L
D
S
L
-
L
D
Y
P
T
SL
Q
T
I
I
G
V
D
I
S
P
K
G
L
A
R
A
A
K
M
L
H
V
K
--------
L
N
K
E
A
C
N
V
K
S
---
A
T
L
Y
----
D
G
S
---------
I
--
L
----
E
--
F
D
S
R
L
H
D
--
V
D
I
G
T
C
--
L
E
-
V
I
E
H
M
-
E
E
-
D
Q
A
C
E
F
G
E
K
V
L
S
L
F
H
P
K
L
L
I
V
S
-----
T
P
N
--
Y
--
E
F
N
--
T
I
L
Q
--------
R
S
T
L
P
K
-
F
R
N
H
D
H
K
F
E
W
T
---
R
E
-
Q
F
N
Q
W
A
S
K
-
L
--
G
K
R
H
N
Y
S
V
E
F
S
G
V
G
G
30
PsiBlast_CBE
55.34
32%
-69
- C1 -
3HTX
3
HEN1_ARATH
A:
[704-784]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
L
S
K
Q
R
V
E
Y
A
L
------
K
H
I
------
R
E
S
S
A
-
S
T
L
V
D
--------
F
G
C
G
S
G
S
L
L
D
S
L
-
L
D
Y
P
T
SL
Q
T
I
I
G
V
D
I
S
P
K
G
L
A
R
A
A
K
M
L
H
V
K
--------
L
N
K
E
A
C
N
V
K
S
---
A
T
L
Y
----
D
G
S
---------
I
--
L
----
E
--
F
D
S
R
L
H
D
--
V
D
I
G
T
C
--
L
E
-
V
I
E
H
M
-
E
E
-
D
Q
A
C
E
F
G
E
K
V
L
S
L
F
H
P
K
L
L
I
V
S
-----
T
P
N
--
Y
--
E
F
N
--
T
I
L
Q
--------
R
S
Q
L
P
K
-
F
R
N
H
D
H
K
F
E
W
T
---
R
E
-
Q
F
N
Q
W
A
S
K
-
L
--
G
K
R
H
N
Y
S
V
E
F
S
G
V
G
G
40
Fugue
51.97
17%
-61
- C1 -
3EGV
7
PRMA_THET8
A:
[1-254]
-----------------------------------------------------------------------------M
W
V
Y
R
L
K
G
T
L
E
A
L
D
P
I
L
P
G
L
F
D
G
G
A
R
G
L
W
E
R
E
G
E
V
W
A
F
F
P
A
P
V
---
D
L
P
Y
E
G
V
W
---
E
E
V
G
D
E
D
W
L
E
A
W
R
R
D
L
K
---
P
A
L
A
--------
P
P
F
V
V
L
A
P
W
H
T
W
E
G
-------------------
A
E
I
P
L
V
I
E
P
G
M
AFGTGH
H
E
T
------
T
R
L
A
L
-
K
A
L
A
R
HLRPG
D
K
V
L
D
L
G
T
G
S
G
V
L
A
I
A
A
E
K
L
G
--
G
K
A
L
G
V
D
I
D
P
M
V
L
P
Q
A
E
A
N
A
K
R
N
--------
G
V
R
P
R
F
L
E
G
S
---
L
E
A
A
----
L
P
F
---------
G
--
P
----
F
--
D
L
L
V
A
N
L
Y
A
E
L
H
A
A
L
--
A
P
-
R
Y
R
E
A
-
L
V
-
P
G
G
R
A
L
L
T
G
I
L
--------------------------------------------
K
D
R
-
A
P
L
V
R
E
A
M
A
G
A
---
G
F
-
R
P
L
E
E
A
A
E
-
G
--
E
------
W
V
L
L
A
Y
G
R