@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_1023: (2015-12-20 )
MAHILVSGATSGFGLEIAKAFLQKNHVVFGTGRRQENLQKLQLAYPKRFIPLCFDLQNKPETKRAIETIFSMTDRIDALINNAGLALGLNKAYECELDDWEVMIDTNIKGLLHLTRLILPSMIEHDQGTIINLGSIAGTYAYPGGNVYGASKAFVKQFSLNLRADLAGTNIRVSNVEPGLCGETEFSMVRFKGDKIKAQSVYENTLYLKPQDIANIVLWIYEQPSHVNINRIEIMPTSQTFAPLPTHKNP
Atome Classification :
(25 SA)
.........10........20.....---...30........40-----.---..----...---..50..--......60........70........80........90........100.......110.......120...--...-.130.......140...--....150.......160....--...170.......-----180.......190.......200.....----..210.......220.......230.......240.......250
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
A
H
I
L
VSGATSG
F
G
L
E
I
A
K
A
F
L
QKN
H
---
V
V
F
GTGR
R
Q
E
N
L
Q
K
L
-----
Q
---
L
A----YPK---
R
F
I
P
L
C
--FDLQNKP
E
T
K
R
A
I
E
T
I
F
S
M
T
D
R
I
D
A
L
I
NNAG
L
A
LGLNK
A
Y
E
CELD
D
W
E
V
M
I
DTN
I
K
G
L
L
H
L
T
R
L
I
L
P
S
M
I
EH--DQ
G
-
T
I
I
N
LGS
I
A
G
T
Y
AYPGG--NVYG
A
S
K
A
F
V
K
Q
F
S
L
N
L
R
A
DL--AGT
N
I
R
V
SNVEPG-----LCGETE
F
S
M
V
R
FKGDK
I
K
A
Q
S
VYEN
T
L
Y
----L
K
P
Q
D
I
A
N
I
V
L
W
I
YEQPSH
V
N
I
N
R
I
E
I
MPTSQTFAPLPTHKNP
23
PsiBlast_CBE
93.53
50%
-96
- C1 -
3ASV
2
?
D:
[3-247]
---
V
L
V
T
G
A
T
A
G
F
G
E
C
I
T
R
R
F
I
Q
Q
G
H
---
K
V
I
A
T
G
R
R
Q
E
R
L
Q
E
L
-----
K
---
D
E
----
L
G
D
---
N
L
Y
I
A
Q
--
L
D
V
R
N
R
A
A
I
E
E
M
L
A
S
L
P
A
E
W
C
N
I
D
I
L
V
N
N
A
G
L
A
L
G
M
E
P
A
H
K
A
S
V
E
D
W
E
T
M
I
D
T
N
N
K
G
L
V
Y
M
T
R
A
V
L
P
G
M
V
E
R
--
N
H
G
-
H
I
I
N
I
G
S
T
A
G
S
W
P
Y
A
G
G
--
N
V
Y
G
A
T
K
A
F
V
R
Q
F
S
L
N
L
R
T
D
L
--
H
G
T
A
V
R
V
T
D
I
E
P
G
-----
L
V
G
G
T
E
F
S
N
V
R
F
K
G
D
D
G
K
A
E
K
T
Y
Q
N
T
V
A
----
L
T
P
E
D
V
S
E
A
V
W
W
V
S
T
L
P
A
H
V
N
I
N
T
L
E
M
M
P
V
T
Q
S
Y
A
G
L
N
V
H
R
Q
-
25
PsiBlast_CBE
93.49
50%
-93
- C1 -
3ASV
2
?
B:
[3-247]
---
V
L
V
T
G
A
T
A
G
F
G
E
C
I
T
R
R
F
I
Q
Q
G
H
---
K
V
I
A
T
G
R
R
Q
E
R
L
Q
E
L
-----
K
---
D
E
----
L
G
D
---
N
L
Y
I
A
Q
--
L
D
V
R
N
R
A
A
I
E
E
M
L
A
S
L
P
A
E
W
C
N
I
D
I
L
V
N
N
A
G
L
A
L
G
M
E
P
A
H
K
A
S
V
E
D
W
E
T
M
I
D
T
N
N
K
G
L
V
Y
M
T
R
A
V
L
P
G
M
V
E
R
--
N
H
G
-
H
I
I
N
I
G
S
T
A
G
S
W
P
Y
A
G
G
--
N
V
Y
G
A
T
K
A
F
V
R
Q
F
S
L
N
L
R
T
D
L
--
H
G
T
A
V
R
V
T
D
I
E
P
G
-----
L
V
G
G
T
E
F
S
N
V
R
F
K
G
D
D
G
K
A
E
K
T
Y
Q
N
T
V
A
----
L
T
P
E
D
V
S
E
A
V
W
W
V
S
T
L
P
A
H
V
N
I
N
T
L
E
M
M
P
V
T
Q
S
Y
A
G
L
N
V
H
R
Q
-
2
PsiBlast_PDB
93.03
50%
-93
- C1 -
3ASV
2
?
A:
[3-247]
---
V
L
V
T
G
A
T
A
G
F
G
E
C
I
T
R
R
F
I
Q
Q
G
H
---
K
V
I
A
T
G
R
R
Q
E
R
L
Q
E
L
-----
K
---
D
E
----
L
G
D
---
N
L
Y
I
A
Q
--
L
D
V
R
N
R
A
A
I
E
E
M
L
A
S
L
P
A
E
W
C
N
I
D
I
L
V
N
N
A
G
L
A
L
G
M
E
P
A
H
K
A
S
V
E
D
W
E
T
M
I
D
T
N
N
K
G
L
V
Y
M
T
R
A
V
L
P
G
M
V
E
R
--
N
H
G
-
H
I
I
N
I
G
S
T
A
G
S
W
P
Y
A
G
G
--
N
V
Y
G
A
T
K
A
F
V
R
Q
F
S
L
N
L
R
T
D
L
--
H
G
T
A
V
R
V
T
D
I
E
P
G
-----
L
V
G
G
T
E
F
S
N
V
R
F
K
G
D
D
G
K
A
E
K
T
Y
Q
N
T
V
A
----
L
T
P
E
D
V
S
E
A
V
W
W
V
S
T
L
P
A
H
V
N
I
N
T
L
E
M
M
P
V
T
Q
S
Y
A
G
L
N
V
H
R
Q
-
22
PsiBlast_CBE
92.87
50%
-93
- C1 -
3ASV
2
?
E:
[3-247]
---
V
L
V
T
G
A
T
A
G
F
G
E
C
I
T
R
R
F
I
Q
Q
G
H
---
K
V
I
A
T
G
R
R
Q
E
R
L
Q
E
L
-----
K
---
D
E
----
L
G
D
---
N
L
Y
I
A
Q
--
L
D
V
R
N
R
A
A
I
E
E
M
L
A
S
L
P
A
E
W
C
N
I
D
I
L
V
N
N
A
G
L
A
L
G
M
E
P
A
H
K
A
S
V
E
D
W
E
T
M
I
D
T
N
N
K
G
L
V
Y
M
T
R
A
V
L
P
G
M
V
E
R
--
N
H
G
-
H
I
I
N
I
G
S
T
A
G
S
W
P
Y
A
G
G
--
N
V
Y
G
A
T
K
A
F
V
R
Q
F
S
L
N
L
R
T
D
L
--
H
G
T
A
V
R
V
T
D
I
E
P
G
-----
L
V
G
G
T
E
F
S
N
V
R
F
K
G
D
D
G
K
A
E
K
T
Y
Q
N
T
V
A
----
L
T
P
E
D
V
S
E
A
V
W
W
V
S
T
L
P
A
H
V
N
I
N
T
L
E
M
M
P
V
T
Q
S
Y
A
G
L
N
V
H
R
Q
-
24
PsiBlast_CBE
92.55
50%
-92
- C1 -
3ASV
2
?
C:
[3-247]
---
V
L
V
T
G
A
T
A
G
F
G
E
C
I
T
R
R
F
I
Q
Q
G
H
---
K
V
I
A
T
G
R
R
Q
E
R
L
Q
E
L
-----
K
---
D
E
----
L
G
D
---
N
L
Y
I
A
Q
--
L
D
V
R
N
R
A
A
I
E
E
M
L
A
S
L
P
A
E
W
C
N
I
D
I
L
V
N
N
A
G
L
A
L
G
M
E
P
A
H
K
A
S
V
E
D
W
E
T
M
I
D
T
N
N
K
G
L
V
Y
M
T
R
A
V
L
P
G
M
V
E
R
--
N
H
G
-
H
I
I
N
I
G
S
T
A
G
S
W
P
Y
A
G
G
--
N
V
Y
G
A
T
K
A
F
V
R
Q
F
S
L
N
L
R
T
D
L
--
H
G
T
A
V
R
V
T
D
I
E
P
G
-----
L
V
G
G
T
E
F
S
N
V
R
F
K
G
D
D
G
K
A
E
K
T
Y
Q
N
T
V
A
----
L
T
P
E
D
V
S
E
A
V
W
W
V
S
T
L
P
A
H
V
N
I
N
T
L
E
M
M
P
V
T
Q
S
Y
A
G
L
N
V
H
R
Q
-
21
PsiBlast_CBE
91.75
50%
-91
- C1 -
3ASV
2
?
F:
[3-247]
---
V
L
V
T
G
A
T
A
G
F
G
E
C
I
T
R
R
F
I
Q
Q
G
H
---
K
V
I
A
T
G
R
R
Q
E
R
L
Q
E
L
-----
K
---
D
E
----
L
G
D
---
N
L
Y
I
A
Q
--
L
D
V
R
N
R
A
A
I
E
E
M
L
A
S
L
P
A
E
W
C
N
I
D
I
L
V
N
N
A
G
L
A
L
G
M
E
P
A
H
K
A
S
V
E
D
W
E
T
M
I
D
T
N
N
K
G
L
V
Y
M
T
R
A
V
L
P
G
M
V
E
R
--
N
H
G
-
H
I
I
N
I
G
S
T
A
G
S
W
P
Y
A
G
G
--
N
V
Y
G
A
T
K
A
F
V
R
Q
F
S
L
N
L
R
T
D
L
--
H
G
T
A
V
R
V
T
D
I
E
P
G
-----
L
V
G
G
T
E
F
S
N
V
R
F
K
G
D
D
G
K
A
E
K
T
Y
Q
N
T
V
A
----
L
T
P
E
D
V
S
E
A
V
W
W
V
S
T
L
P
A
H
V
N
I
N
T
L
E
M
M
P
V
T
Q
S
Y
A
G
L
N
V
H
R
Q
-
1
PsiBlast_PDB
86.14
50%
-93
- C1 -
3ASU
-
?
A:
[3-240]
---
V
L
V
T
G
A
T
A
G
F
G
E
C
I
T
R
R
F
I
Q
Q
G
H
---
K
V
I
A
T
G
R
R
Q
E
R
L
Q
E
L
-----
K
---
D
E
----
L
G
D
---
N
L
Y
I
A
Q
--
L
D
V
R
N
R
A
A
I
E
E
M
L
A
S
L
P
A
E
W
C
N
I
D
I
L
V
N
N
A
G
L
A
L
G
M
E
P
A
H
K
A
S
V
E
D
W
E
T
M
I
D
T
N
N
K
G
L
V
Y
M
T
R
A
V
L
P
G
M
V
E
R
--
N
H
G
-
H
I
I
N
I
G
S
T
A
G
S
W
P
Y
A
G
G
--
N
V
Y
G
A
T
K
A
F
V
R
Q
F
S
L
N
L
R
T
D
L
--
H
G
T
A
V
R
V
T
D
I
E
P
G
-----
L
V
G
G
----------------------
V
A
----
L
T
P
E
D
V
S
E
A
V
W
W
V
S
T
L
P
A
H
V
N
I
N
T
L
E
M
M
P
V
T
Q
S
Y
---------
3
PsiBlast_PDB
86.03
48%
-93
- C1 -
2NWQ
1
?
A:
[24-269]
---
L
F
I
T
G
A
T
S
G
F
G
E
A
C
A
R
R
F
A
E
A
G
W
---
S
L
V
L
T
G
R
R
E
E
R
L
Q
A
L
A
G
---
E
---
L
S
----
A
K
T
---
R
V
L
P
L
T
--
L
D
V
R
D
R
A
A
M
S
A
A
V
D
N
L
P
E
E
F
A
T
L
R
G
L
I
N
N
A
G
L
A
L
G
T
D
P
A
Q
S
C
D
L
D
D
W
D
T
M
V
D
T
N
I
K
G
L
L
Y
S
T
R
L
L
L
P
R
L
I
A
H
--
G
A
G
A
S
I
V
N
L
G
S
V
A
G
K
W
P
Y
P
G
S
--
H
V
Y
G
G
T
K
A
F
V
E
Q
F
S
L
N
L
R
C
D
L
--
Q
G
T
G
V
R
V
T
N
L
E
P
G
-----
L
C
-
E
--------------------
G
A
H
P
----
I
Q
P
E
D
I
A
E
T
I
F
W
I
M
N
Q
P
A
H
L
N
I
N
S
L
E
I
M
P
V
S
Q
S
W
A
G
F
A
I
H
---
4
PsiBlast_PDB
79.35
34%
-88
- C1 -
3RKU
1
YM71_YEAST
A:
[36-278]
---
V
L
I
T
G
A
S
A
G
I
G
K
A
T
A
L
E
Y
L
E
A
S
N
GD
M
K
L
I
L
A
A
R
R
L
E
K
L
E
E
L
-----
K
---
K
T
I
D
Q
E
F
P
N
---
A
K
V
H
V
A
Q-
L
D
I
T
Q
A
E
K
I
K
P
F
I
E
N
L
P
Q
E
F
K
D
I
D
I
L
V
N
N
A
G
K
A
L
G
S
D
R
V
G
Q
I
A
T
E
D
I
Q
D
V
F
D
T
N
V
T
A
L
I
N
I
T
Q
A
V
L
P
I
F
Q
A
K
--
N
S
G
-
D
I
V
N
L
G
S
I
A
G
R
D
A
Y
P
T
G
--
S
I
Y
C
A
S
K
F
A
V
G
A
F
T
D
S
L
R
K
E
L
--
I
N
T
K
I
R
V
I
L
I
A
P
G
-----
L
V
-
E
T
E
F
S
L
V
R
Y
R
G
N
E
E
Q
A
K
N
V
Y
K
D
T
T
P
----
L
M
A
D
D
V
A
D
L
I
V
Y
A
T
S
R
K
Q
N
T
V
I
A
D
T
L
I
F
P
T
N
Q
A
S
P
H
H
I
F
R
G
--
28
PsiBlast_CBE
78.33
34%
-88
- C1 -
3RKU
1
YM71_YEAST
B:
[36-278]
---
V
L
I
T
G
A
S
A
G
I
G
K
A
T
A
L
E
Y
L
E
A
S
N
GDM
K
L
I
L
A
A
R
R
L
E
K
L
E
E
L
-----
K
---
K
T
IDQE
F
P
N
---
A
K
V
H
V
A
Q-
L
D
I
T
Q
A
E
K
I
K
P
F
I
E
N
L
P
Q
E
F
K
D
I
D
I
L
V
N
N
A
G
K
A
L
G
S
D
R
V
G
Q
I
A
T
E
D
I
Q
D
V
F
D
T
N
V
T
A
L
I
N
I
T
Q
A
V
L
P
I
F
Q
A
K
--
N
S
G
-
D
I
V
N
L
G
S
I
A
G
R
D
A
Y
P
T
G
--
S
I
Y
C
A
S
K
F
A
V
G
A
F
T
D
S
L
R
K
E
L
--
I
N
T
K
I
R
V
I
L
I
A
P
G
-----
L
V
-
E
T
E
F
S
L
V
R
Y
R
G
N
E
E
Q
A
K
N
V
Y
K
D
T
T
P
----
L
M
A
D
D
V
A
D
L
I
V
Y
A
T
S
R
K
Q
N
T
V
I
A
D
T
L
I
F
P
T
N
Q
A
S
P
H
H
I
F
R
G
--
26
PsiBlast_CBE
77.23
34%
-89
- C1 -
3RKU
1
YM71_YEAST
D:
[36-278]
---
V
L
I
T
G
A
S
A
G
I
G
K
A
T
A
L
E
Y
L
E
A
S
N
GDM
K
L
I
L
A
A
R
R
L
E
K
L
E
E
L
-----
K
---
K
T
IDQE
F
P
N
---
A
K
V
H
V
A
Q-
L
D
I
T
Q
A
E
K
I
K
P
F
I
E
N
L
P
Q
E
F
K
D
I
D
I
L
V
N
N
A
G
K
A
L
G
S
D
R
V
G
Q
I
A
T
E
D
I
Q
D
V
F
D
T
N
V
T
A
L
I
N
I
T
Q
A
V
L
P
I
F
Q
A
K
--
N
S
G
-
D
I
V
N
L
G
S
I
A
G
R
D
A
Y
P
T
G
--
S
I
Y
C
A
S
K
F
A
V
G
A
F
T
D
S
L
R
K
E
L
--
I
N
T
K
I
R
V
I
L
I
A
P
G
-----
L
V
-
E
T
E
F
S
L
V
R
Y
R
G
N
E
E
Q
A
K
N
V
Y
K
D
T
T
P
----
L
M
A
D
D
V
A
D
L
I
V
Y
A
T
S
R
K
Q
N
T
V
I
A
D
T
L
I
F
P
T
N
Q
A
S
P
H
H
I
F
R
G
--
27
PsiBlast_CBE
76.19
34%
-86
- C1 -
3RKU
1
YM71_YEAST
C:
[36-278]
---
V
L
I
T
G
A
S
A
G
I
G
K
A
T
A
L
E
Y
L
E
A
S
N
GDM
K
L
I
L
A
A
R
R
L
E
K
L
E
E
L
-----
K
---
K
T
IDQE
F
P
N
---
A
K
V
H
V
A
Q-
L
D
I
T
Q
A
E
K
I
K
P
F
I
E
N
L
P
Q
E
F
K
D
I
D
I
L
V
N
N
A
G
K
A
L
G
S
D
R
V
G
Q
I
A
T
E
D
I
Q
D
V
F
D
T
N
V
T
A
L
I
N
I
T
Q
A
V
L
P
I
F
Q
A
K
--
N
S
G
-
D
I
V
N
L
G
S
I
A
G
R
D
A
Y
P
T
G
--
S
I
Y
C
A
S
K
F
A
V
G
A
F
T
D
S
L
R
K
E
L
--
I
N
T
K
I
R
V
I
L
I
A
P
G
-----
L
V
-
E
T
E
F
S
L
V
R
Y
R
G
N
E
E
Q
A
K
N
V
Y
K
D
T
T
P
----
L
M
A
D
D
V
A
D
L
I
V
Y
A
T
S
R
K
Q
N
T
V
I
A
D
T
L
I
F
P
T
N
Q
A
S
P
H
H
I
F
R
G
--
6
PsiBlast_PDB
76.06
33%
-85
- C1 -
1XG5
2
DHR11_HUMAN
A:
[36-277]
----
L
V
T
G
A
S
G
G
I
G
A
A
V
A
R
A
L
V
Q
Q
G
L
---
K
V
V
G
C
A
R
T
V
G
N
I
E
E
L
A
A
E
C
K
S
---
A
G
----
Y
P
G
---
T
L
I
P
Y
R
--
C
D
L
S
N
E
E
D
I
L
S
M
F
S
A
I
R
S
Q
H
S
G
V
D
I
C
I
N
N
A
G
L
A
R
P
-
D
T
L
L
S
G
S
T
S
G
W
K
D
M
F
N
V
N
V
L
A
L
S
I
C
T
R
E
A
Y
Q
S
M
K
E
R
NV
D
D
G
-
H
I
I
N
I
N
S
M
S
G
H
R
V
L
P
L
S
VT
H
F
Y
S
A
T
K
Y
A
V
T
A
L
T
E
G
L
R
Q
E
L
R
E
A
Q
T
H
I
R
A
T
C
I
S
P
G
-----
V
V
-
E
T
Q
F
A
F
K
L
H
D
K
D
P
E
K
A
A
A
T
Y
E
---
C
----
L
K
P
E
D
V
A
E
A
V
I
Y
V
L
S
T
P
A
H
I
Q
I
G
D
I
Q
M
R
P
T
G
S
-----------
31
PsiBlast_CBE
75.83
33%
-85
- C1 -
1XG5
2
DHR11_HUMAN
C:
[36-277]
----
L
V
T
G
A
S
G
G
I
G
A
A
V
A
R
A
L
V
Q
Q
G
L
---
K
V
V
G
C
A
R
T
V
G
N
I
E
E
L
AAECK
S
---
A
G
----
Y
P
G
---
T
L
I
P
Y
R
--
C
D
L
S
N
E
E
D
I
L
S
M
F
S
A
I
R
S
Q
H
S
G
V
D
I
C
I
N
N
A
G
L
A
R
P
-
D
T
L
L
S
G
S
T
S
G
W
K
D
M
F
N
V
N
V
L
A
L
S
I
C
T
R
E
A
Y
Q
S
M
K
E
R
NV
D
D
G
-
H
I
I
N
I
N
S
M
S
G
H
R
V
L
P
L
S
VT
H
F
Y
S
A
T
K
Y
A
V
T
A
L
T
E
G
L
R
Q
E
L
RE
A
Q
T
H
I
R
A
T
C
I
S
P
G
-----
V
V
-
E
T
Q
F
A
F
K
L
H
D
K
D
P
E
K
A
A
A
T
Y
E
Q
M
K
C
----
L
K
P
E
D
V
A
E
A
V
I
Y
V
L
S
T
P
A
H
I
Q
I
G
D
I
Q
M
R
P
T
G
S
-----------
35
PsiBlast_CBE
75.69
32%
-99
- C1 -
3P19
1
?
B:
[19-251]
---
V
V
I
T
G
A
S
S
G
I
G
E
A
I
A
R
R
F
S
E
E
G
H
---
P
L
L
L
L
A
R
R
V
E
R
L
K
A
L
-----
N
---
L
------
P
N
------
T
L
C
A
Q
V
D
V
T
D
K
Y
T
F
D
T
A
I
T
R
A
E
K
I
Y
G
P
A
D
A
I
V
N
N
A
G
M
M
L
-
L
G
Q
I
D
T
Q
E
A
N
E
W
Q
R
M
F
D
V
N
V
L
G
L
L
N
G
M
Q
A
V
L
A
P
M
K
A
R
--
N
C
G
-
T
I
I
N
I
S
S
I
A
G
K
K
T
F
P
D
H
--
A
A
Y
C
G
T
K
F
A
V
H
A
I
S
E
N
V
R
E
E
V
--
A
A
S
N
V
R
V
M
T
I
A
P
S
AVKTE
L
L
S
---------------------
G
G
V
-----
L
A
A
D
D
V
A
R
A
V
L
F
A
Y
Q
Q
P
Q
N
V
C
I
R
E
I
A
L
A
P
T
K
Q
-----------
36
PsiBlast_CBE
74.93
31%
-99
- C1 -
3TFO
5
?
D:
[7-239]
---
I
L
I
T
G
A
S
G
G
I
G
E
G
I
A
R
E
L
G
V
A
G
A
---
K
I
L
L
G
A
R
R
Q
A
R
I
E
A
I
-----
A
---
T
E
----
I
R
D
AGG
T
A
L
A
Q
V
--
L
D
V
T
D
R
H
S
V
A
A
F
A
Q
A
A
V
D
T
W
G
R
I
D
V
L
V
N
N
A
G
V
-
M
P
L
S
P
L
A
A
V
K
V
D
E
W
E
R
M
I
D
V
N
I
K
G
V
L
W
G
I
G
A
V
L
P
I
M
E
A
Q
--
R
S
G
-
Q
I
I
N
I
G
S
I
G
A
L
S
V
V
P
T
A
--
A
V
Y
C
A
T
K
F
A
V
R
A
I
S
D
G
L
R
Q
E
----
S
T
N
I
R
V
T
C
V
N
P
G
-----
V
V
-
E
---------------------
A
I
A
----
L
Q
P
A
D
I
A
R
A
V
R
Q
V
I
E
A
P
Q
S
V
D
T
T
E
I
T
I
R
P
T
A
S
-----------
37
PsiBlast_CBE
73.65
31%
-99
- C1 -
3TFO
5
?
B:
[7-239]
---
I
L
I
T
G
A
S
G
G
I
G
E
G
I
A
R
E
L
G
V
A
G
A
---
K
I
L
L
G
A
R
R
Q
A
R
I
E
A
I
-----
A
---
T
E
----
I
R
D
A
G
G
T
A
L
A
Q
V
--
L
D
V
T
D
R
H
S
V
A
A
F
A
Q
A
A
V
D
T
W
G
R
I
D
V
L
V
N
N
A
G
V
-
M
P
L
S
P
L
A
A
V
K
V
D
E
W
E
R
M
I
D
V
N
I
K
G
V
L
W
G
I
G
A
V
L
P
I
M
E
A
Q
--
R
S
G
-
Q
I
I
N
I
G
S
I
G
A
L
S
V
V
P
T
A
--
A
V
Y
C
A
T
K
F
A
V
R
A
I
S
D
G
L
R
Q
E
----
S
T
N
I
R
V
T
C
V
N
P
G
-----
V
V
------------------------
I
A
----
L
Q
P
A
D
I
A
R
A
V
R
Q
V
I
E
A
P
Q
S
V
D
T
T
E
I
T
I
R
P
T
A
------------
30
PsiBlast_CBE
73.57
33%
-82
- C1 -
1XG5
2
DHR11_HUMAN
D:
[36-277]
----
L
V
T
G
A
S
G
G
I
G
A
A
V
A
R
A
L
V
Q
Q
G
L
---
K
V
V
G
C
A
R
T
V
G
N
I
E
E
L
AAECK
S
---
A
G
----
Y
P
G
---
T
L
I
P
Y
R
--
C
D
L
S
N
E
E
D
I
L
S
M
F
S
A
I
R
S
Q
H
S
G
V
D
I
C
I
N
N
A
G
L
A
R
P
-
D
T
L
L
S
G
S
T
S
G
W
K
D
M
F
N
V
N
V
L
A
L
S
I
C
T
R
E
A
Y
Q
S
M
K
E
R
NV
D
D
G
-
H
I
I
N
I
N
S
M
S
G
H
R
V
L
P
L
S
VT
H
F
Y
S
A
T
K
Y
A
V
T
A
L
T
E
G
L
R
Q
E
L
RE
A
Q
T
H
I
R
A
T
C
I
S
P
G
-----
V
V
-
E
T
Q
F
A
F
K
L
H
D
K
D
P
E
K
A
A
A
T
Y
E
Q
M
K
C
----
L
K
P
E
D
V
A
E
A
V
I
Y
V
L
S
T
P
A
H
I
Q
I
G
D
I
Q
M
R
P
T
G
S
-----------
34
PsiBlast_CBE
72.05
32%
-99
- C1 -
3P19
1
?
C:
[19-251]
---
V
V
I
T
G
A
S
S
G
I
G
E
A
I
A
R
R
F
S
E
E
G
H
---
P
L
L
L
L
A
R
R
V
E
R
L
K
A
L
-----
N
---
L
------
P
N
------
T
L
C
AQ
V
D
V
T
D
K
Y
T
F
D
T
A
I
T
R
A
E
K
I
Y
G
P
A
D
A
I
V
N
N
A
G
M
M
L
-
L
G
Q
I
D
T
Q
E
A
N
E
W
Q
R
M
F
D
V
N
V
L
G
L
L
N
G
M
Q
A
V
L
A
P
M
K
A
R
--
N
C
G
-
T
I
I
N
I
S
S
I
A
G
K
K
T
F
P
D
H
--
A
A
Y
C
G
T
K
F
A
V
H
A
I
S
E
N
V
R
E
E
V
--
A
A
S
N
V
R
V
M
T
I
A
P
S
AVKTE
L
L
S
---------------------
G
G
V
-----
L
A
A
D
D
V
A
R
A
V
L
F
A
Y
Q
Q
P
Q
N
V
C
I
R
E
I
A
L
A
P
T
K
Q
-----------
29
PsiBlast_CBE
71.33
31%
-102
- C1 -
2EHD
1
?
B:
[8-227]
---
V
L
I
T
G
A
S
R
G
I
G
E
A
T
A
R
L
L
H
A
K
G
Y
---
R
V
G
L
M
A
R
D
E
K
R
L
Q
A
L
-----
A
----
A
----
E
L
E
---
G
A
L
P
L
P
--
G
D
V
R
E
E
G
D
W
A
R
A
V
A
A
M
E
E
A
F
G
E
L
S
A
L
V
N
N
A
G
V
G
V
-
M
K
P
V
H
E
L
T
L
E
E
W
R
L
V
L
D
T
N
L
T
G
A
F
L
G
I
R
H
A
V
P
A
L
L
R
R
--
G
G
G
-
T
I
V
N
V
G
S
L
A
G
K
N
P
F
K
G
G
--
A
A
Y
N
A
S
K
F
G
L
L
G
L
A
G
A
A
M
L
D
L
--
R
E
A
N
V
R
V
V
N
V
L
P
G
-----
S
V
-------------------------
K
----
L
K
P
E
D
V
A
Q
A
V
L
F
A
L
E
M
P
G
H
A
M
V
S
E
I
E
L
R
P
T
-------------
8
PsiBlast_PDB
64.40
31%
-79
- C1 -
2JAP
2
?
A:
[11-246]
----
L
I
T
G
A
S
S
G
I
G
E
A
T
A
R
A
L
A
A
E
G
A
---
A
V
A
I
A
A
R
R
V
E
K
L
R
A
L
-----
G
D
E
L
T
A
----
A
G
A
---
K
V
H
V
L
E
--
L
D
V
A
D
R
Q
G
V
D
A
A
V
A
S
T
V
E
A
L
G
G
L
D
I
L
V
N
N
A
G
I
M
L
-
L
G
P
V
E
D
A
D
T
T
D
W
T
R
M
I
D
T
N
L
L
G
L
M
Y
M
T
R
A
A
L
P
H
L
L
R
---
S
K
G
-
T
V
V
Q
M
S
S
I
A
G
R
V
N
V
R
N
A
--
A
V
Y
Q
A
T
K
F
G
V
N
A
F
S
E
T
L
R
Q
E
V
--
T
E
R
G
V
R
V
V
V
I
E
P
G
-----
T
T
-
D
T
E
L
---
R
G
H
I
T
H
T
A
T
K
E
M
Y
E
Q
R
I
S
QIRK
L
Q
A
Q
D
I
A
E
A
V
R
Y
A
V
T
A
P
H
H
A
T
V
H
E
I
F
I
R
P
T
D
Q
V
----------
11
PsiBlast_PDB
64.03
31%
-79
- C1 -
2JAH
1
?
A:
[11-246]
----
L
I
T
G
A
S
S
G
I
G
E
A
T
A
R
A
L
A
A
E
G
A
---
A
V
A
I
A
A
R
R
V
E
K
L
R
A
L
-----
G
D
E
L
T
A
----
A
G
A
---
K
V
H
V
L
E
--
L
D
V
A
D
R
Q
G
V
D
A
A
V
A
S
T
V
E
A
L
G
G
L
D
I
L
V
N
N
A
G
I
M
L
-
L
G
P
V
E
D
A
D
T
T
D
W
T
R
M
I
D
T
N
L
L
G
L
M
Y
M
T
R
A
A
L
P
H
L
L
R
---
S
K
G
-
T
V
V
Q
M
S
S
I
A
G
R
V
N
V
R
N
A
--
A
V
Y
Q
A
T
K
F
G
V
N
A
F
S
E
T
L
R
Q
E
V
--
T
E
R
G
V
R
V
V
V
I
E
P
G
-----
T
T
-
D
T
E
L
---
R
G
H
I
T
H
T
A
T
K
E
M
Y
E
Q
R
I
S
QIRK
L
Q
A
Q
D
I
A
E
A
V
R
Y
A
V
T
A
P
H
H
A
T
V
H
E
I
F
I
R
P
T
D
Q
V
----------
38
PsiBlast_CBE
63.96
31%
-79
- C1 -
2JAP
2
?
D:
[11-246]
----
L
I
T
G
A
S
S
G
I
G
E
A
T
A
R
A
L
A
A
E
G
A
---
A
V
A
I
A
A
R
R
V
E
K
L
R
A
L
-----
G
DEL
T
A
----
A
G
A
---
K
V
H
V
L
E
--
L
D
V
A
D
R
Q
G
V
D
A
A
V
A
S
T
V
E
A
L
G
G
L
D
I
L
V
N
N
A
G
I
M
L
-
L
G
P
V
E
D
A
D
T
T
D
W
T
R
M
I
D
T
N
L
L
G
L
M
Y
M
T
R
A
A
L
P
H
L
L
R
---
S
K
G
-
T
V
V
Q
M
S
S
I
A
G
R
V
N
V
R
N
A
--
A
V
Y
Q
A
T
K
F
G
V
N
A
F
S
E
T
L
R
Q
E
V
--
T
E
R
G
V
R
V
V
V
I
E
P
G
-----
T
T
-
D
T
E
L
---
R
G
H
I
T
H
T
A
T
K
E
M
Y
E
Q
R
I
S
QIRK
L
Q
A
Q
D
I
A
E
A
V
R
Y
A
V
T
A
P
H
H
A
T
V
H
E
I
F
I
R
P
T
D
Q
V
----------
40
PsiBlast_CBE
63.49
31%
-79
- C1 -
2JAP
2
?
B:
[11-246]
----
L
I
T
G
A
S
S
G
I
G
E
A
T
A
R
A
L
A
A
E
G
A
---
A
V
A
I
A
A
R
R
V
E
K
L
R
A
L
-----
G
D
E
L
T
A
----
A
G
A
---
K
V
H
V
L
E
--
L
D
V
A
D
R
Q
G
V
D
A
A
V
A
S
T
V
E
A
L
G
G
L
D
I
L
V
N
N
A
G
I
M
L
-
L
G
P
V
E
D
A
D
T
T
D
W
T
R
M
I
D
T
N
L
L
G
L
M
Y
M
T
R
A
A
L
P
H
L
L
R
---
S
K
G
-
T
V
V
Q
M
S
S
I
A
G
R
V
N
V
R
N
A
--
A
V
Y
Q
A
T
K
F
G
V
N
A
F
S
E
T
L
R
Q
E
V
--
T
E
R
G
V
R
V
V
V
I
E
P
G
-----
T
T
-
D
T
E
L
---
R
G
H
I
T
H
T
A
T
K
E
M
Y
E
Q
R
I
S
QIRK
L
Q
A
Q
D
I
A
E
A
V
R
Y
A
V
T
A
P
H
H
A
T
V
H
E
I
F
I
R
P
T
D
Q
V
----------
39
PsiBlast_CBE
61.22
31%
-78
- C1 -
2JAP
2
?
C:
[11-246]
----
L
I
T
G
A
S
S
G
I
G
E
A
T
A
R
A
L
A
A
E
G
A
---
A
V
A
I
A
A
R
R
V
E
K
L
R
A
L
-----
G
DEL
T
A
----
A
G
A
---
K
V
H
V
L
E
--
L
D
V
A
D
R
Q
G
V
D
A
A
V
A
S
T
V
E
A
L
G
G
L
D
I
L
V
N
N
A
G
I
M
L
-
L
G
P
V
E
D
A
D
T
T
D
W
T
R
M
I
D
T
N
L
L
G
L
M
Y
M
T
R
A
A
L
P
H
L
L
R
---
S
K
G
-
T
V
V
Q
M
S
S
I
A
G
R
V
N
V
R
N
A
--
A
V
Y
Q
A
T
K
F
G
V
N
A
F
S
E
T
L
R
Q
E
V
--
T
E
R
G
V
R
V
V
V
I
E
P
G
-----
T
T
-
D
T
E
L
---
R
G
H
I
T
H
T
A
T
K
E
M
Y
E
Q
R
I
S
QIRK
L
Q
A
Q
D
I
A
E
A
V
R
Y
A
V
T
A
P
H
H
A
T
V
H
E
I
F
I
R
P
T
D
Q
V
----------