@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_1079: (2015-12-20 )
MFQALSDGFKNALNKIRFQDDEKALDRALDELKKTLLKNDVHHKVARELLKKVESQTKAGGIGKQQFLDALEKSLLEILSAKGSSGFTFAQTPPTVVLMAGLQGSGKTTTTAKLAHYLKTKNKKVLLCACDLQRLAAVEQLKVLGEQVGVEVFHEENKSVKEIANNALKRAKEAQFDVLIVDSAGRLAIDKELMQELKEVKEVLNPHEVLYVADALSGQDGVKSANTFNEEIGVSGVVLSKFDSDSKGGIALGITYQLGLPLRFIGSGEKIPDLDVFMPERIVGRLMGAGDIISLAEKTASVLNPNEAKDLSKKLKKGQFTFNDFLNQIEKVKKLGSMSSLISMIPGLGNMASALKDTDLESSLEVKKIKAMVNSMTKKERENPEILNGSRRKRIALGSGLEVSEINRIIKRFDQASKMAKRLTNKKGISDLMNLMSQAKNQTPPKMR
Atome Classification :
(47 SA)
.........10.....--...------------20-.........30........40........50..-----.-----.----.-----...-----60...-----.--....-70-----...--......80..----..--.---..---.90----...-------......100.......110.......120.-.-.....130.......140.......150.--.-.-.--..--.-160.......170.......180.......190--.......----200--.------.------.------....210.......220.......230.-......240.......250.......260.......270.......280.......290.......300-.....-..--310...-.-...-320.......330.......340.......350......-.360...-....370.......380.....-----..390.......400.......410.......420.......---430.......440--........
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
F
Q
A
L
S
D
G
F
K
N
A
L
N
KI--RFQ------------
D
--
D
E
K
A
L
D
R
A
L
D
E
L
K
K
T
L
L
KND
V
H
H
K
V
A
R
E
L
L
K
K
V
-----
E
-----
S
----Q-----TKA-----GGI
G
K
-----
Q
--
Q
F
L
D
-
A
------
L
E
K
--
S
L
L
E
I
L
SAKG----SS--G---
F
T
---FA-----QTP-------
P
T
V
V
L
M
AGLQGSGKT
T
T
T
A
K
L
A
H
Y
L
KTKN
K
-
K
-
V
L
L
C
A
C
D
L
Q
R
L
A
A
V
E
Q
L
K
V
L
G
E
Q
VG
V
E
V
F--H-E-E--NK--
S
-
V
K
E
I
A
N
N
A
L
K
R
A
K
EAQF
D
V
L
I
VDSAGRLAI
D
K
E
--
L
M
Q
E
L
K
E
----
V
K
E
--V------L------N------PH
E
V
L
Y
V
A
DALSGQDGVKSANTFNEEIG-VS
G
V
V
L
S
KFDSDSKG
G
I
A
L
G
I
T
Y
QLGL
P
L
R
F
IGSGEKIPD
L
D
VF
M
P
E
R
I
V
G
R
L
MGA
G
D
I
I
S
L
A
E
K
T
A
S
V-LN
P
N
E
-
A
K
--
D
L
S
K
K
L
-
K
-KGQ-F
T
F
N
D
F
L
N
Q
I
E
K
V
K
K
L
G
S
M
S
S
L
I
S
MIPGL
G
N
M
A
S
A
L
KDT-D
L
E
SS
L
E
-
V
K
K
I
K
A
M
V
N
S
M
T
K
KERENPEIL-----NGSR
R
K
R
I
ALGSGL
E
V
S
E
I
N
R
I
I
K
R
F
D
Q
A
S
K
M
A
K
R
L
TNKK
G
I
---
S
D
L
M
N
L
M
S
Q
AK----NQTPPKMR
21
PsiBlast_CBE
92.29
41%
-89
- C5 -
2XXA
3
SRP54_ECOLI
C:
[7-421]
------
D
R
L
S
R
T
L
R
N
I
SG
R
G
R
------------
L
--
T
E
D
N
V
K
D
T
L
R
E
V
R
M
A
L
L
E
A
D
V
A
L
P
V
V
R
E
F
I
N
R
V
-----
K
-----
E
----
K
-----
A
V
G
-----
H
E
V
N
K
SLT
P
G
Q
--
E
F
V
K
-
I
------
V
R
N
--
E
L
V
A
A
M
G
E
E
N
----
Q
T
------
L
N
---
L
A
-----
A
Q
P
-------
P
A
V
V
L
M
A
G
L
Q
G
A
G
K
T
T
S
V
G
K
L
G
K
F
L
R
E
K
H
K
-
K
K
V
L
V
V
S
A
D
V
Y
R
P
A
A
I
K
Q
L
E
T
L
A
E
Q
V
G
V
D
F
F
--
P
-
S
-
D
VG
Q
K
--
P
-
V
-
D
I
V
N
A
A
L
K
E
A
K
L
K
F
Y
D
V
L
L
V
D
T
A
G
R
L
H
V
D
E
A
--
M
M
D
E
I
K
Q
----
V
H
A
--
S
------
I
------
N
------
P
V
E
T
L
F
V
V
D
A
M
T
G
Q
D
A
A
N
T
A
K
A
F
N
E
A
L
P
-
L
T
G
V
V
L
T
K
V
D
G
D
A
R
G
G
A
A
L
S
I
R
H
I
T
G
K
P
I
K
F
L
G
V
G
E
K
T
E
A
L
E
P
F
H
P
D
R
I
A
S
R
I
L
G
M
G
D
V
L
S
L
I
E
D
I
E
S
K
-
V
D
R
A
Q
-
A
E
--
K
L
A
S
K
L
-
K
-
K
G
D
G
F
D
L
N
D
F
L
E
Q
L
R
Q
M
K
N
M
G
G
M
A
S
L
M
G
------------------
D
D
K
V
L
-
V
-
R
M
E
A
I
I
N
S
M
T
M
K
E
R
A
K
P
E
I
I
-----
K
G
S
R
K
R
R
I
A
A
G
S
G
M
Q
V
Q
D
V
N
R
L
L
K
Q
F
D
D
M
Q
R
M
M
K
K
M
K
K
------------------------------
1
PsiBlast_PDB
90.80
41%
-86
- C5 -
2XXA
3
SRP54_ECOLI
A:
[4-421]
---
N
L
T
D
R
L
S
R
T
L
R
N
I
SG
R
G
R
------------
L
--
T
E
D
N
V
K
D
T
L
R
E
V
R
M
A
L
L
E
A
D
V
A
L
P
V
V
R
E
F
I
N
R
V
-----
K
-----
E
----
K
-----
A
V
G
-----
H
E
V
N
K
SLT
P
G
Q
--
E
F
V
K
-
I
------
V
R
N
--
E
L
V
A
A
M
G
E
E
N
----
Q
T
------
L
N
---
L
A
-----
A
Q
P
-------
P
A
V
V
L
M
A
G
L
Q
G
A
G
K
T
T
S
V
G
K
L
G
K
F
L
R
E
K
H
K
-
K
K
V
L
V
V
S
A
D
V
Y
R
P
A
A
I
K
Q
L
E
T
L
A
E
Q
V
G
V
D
F
F
--
P
-
S
-
D
VG
Q
K
--
P
-
V
-
D
I
V
N
A
A
L
K
E
A
K
L
K
F
Y
D
V
L
L
V
D
T
A
G
R
L
H
V
D
E
A
--
M
M
D
E
I
K
Q
----
V
H
A
--
S
------
I
------
N
------
P
V
E
T
L
F
V
V
D
A
M
T
G
Q
D
A
A
N
T
A
K
A
F
N
E
A
L
P
-
L
T
G
V
V
L
T
K
V
D
G
D
A
R
G
G
A
A
L
S
I
R
H
I
T
G
K
P
I
K
F
L
G
V
G
E
K
T
E
A
L
E
P
F
H
P
D
R
I
A
S
R
I
L
G
M
G
D
V
L
S
L
I
E
D
I
E
S
K
-
V
D
R
A
Q
-
A
E
--
K
L
A
S
K
L
-
K
-
K
G
D
G
F
D
L
N
D
F
L
E
Q
L
R
Q
M
K
N
M
G
G
M
A
S
L
M
G
K
-----------------
D
D
K
V
L
-
V
-
R
M
E
A
I
I
N
S
M
T
M
K
E
R
A
K
P
E
I
I
-----
K
G
S
R
K
R
R
I
A
A
G
S
G
M
Q
V
Q
D
V
N
R
L
L
K
Q
F
D
D
M
Q
R
M
M
K
K
M
K
K
------------------------------
106
HHSearch
89.63
33%
-81
- C5 -
3DM5
10
SRP54_PYRFU
A:
[2-435]
V
L
D
N
L
G
K
A
L
A
N
T
L
K
K
I
--
A
R
A
------------
S
SV
D
E
A
L
I
K
E
L
V
R
D
I
Q
R
A
L
I
Q
A
D
V
N
V
R
L
V
L
Q
L
T
R
E
I
-----
Q
-----
R
----
R
-----
A
L
E
EKPPA
G
I
S
K
K
-----
E
--
H
I
I
K
-
I
------
V
Y
E
--
E
L
T
K
F
L
G
T
-
E
----
A
K
--
P
---
I
E
---
I
K
------
E
K
-------
P
T
I
L
L
M
V
G
I
Q
G
S
G
K
T
T
T
V
A
K
L
A
R
Y
F
Q
K
-
R
G
Y
K
-
V
G
V
V
C
S
D
T
W
R
P
G
A
Y
H
Q
L
R
Q
L
L
D
R
Y
H
I
E
V
F
--
G
-
N
-
P
--
Q
E
K-
D
-
A
I
K
L
A
K
E
G
V
D
Y
F
K
S
K
G
V
D
I
I
I
V
D
T
A
G
R
H
K
E
D
K
A
--
L
I
E
E
M
K
Q
----
I
S
N
--
V
------
I
------
H
------
P
H
E
V
I
L
V
I
D
G
T
I
G
Q
Q
A
Y
N
Q
A
L
A
F
K
E
A
T
P
-
I
G
S
I
I
V
T
K
L
D
G
S
A
K
G
G
G
A
L
S
A
V
A
A
T
G
A
P
I
K
F
I
G
T
G
E
K
I
D
D
I
E
P
F
D
P
P
R
F
V
S
R
L
L
G
L
G
D
I
Q
G
L
L
E
K
F
K
E
L
-
E
K
E
V
E
I
K
E
--
E
D
I
E
R
F
-
L
-
R
G
K
-
F
T
L
K
D
M
Y
A
Q
L
E
A
M
R
K
M
G
P
---------------------I
S
I
G
E
-
E
R
-
L
K
K
F
K
V
I
M
D
S
M
T
E
E
E
L
L
N
P
E
I
I
-----
N
Y
S
R
I
K
R
I
A
R
G
S
G
T
S
T
K
D
V
K
E
L
L
D
Q
Y
R
Q
M
K
K
L
F
K
S
M
N
K
R
Q
L
S
--------------------------
105
HHSearch
88.80
40%
-85
- C5 -
2FFH
7
SRP54_THEAQ
A:
[1-418]
M
F
Q
Q
L
S
A
R
L
Q
E
A
I
G
R
L
--
R
G
R
------------
G
RI
T
E
E
D
L
K
A
T
L
R
E
I
R
R
A
L
M
D
A
D
V
N
L
E
V
T
R
D
F
V
E
R
V
-----
R
-----
E
----
E
-----
A
L
G
K
QVLE
S
L
T
P
A
-----
E
--
V
I
L
A
-
T
------
V
Y
E
--
A
L
K
E
A
L
G
G
------
E
A
--
R
---
L
----
P
V
-----
L
K
D
-------
R
N
L
W
F
L
V
G
L
Q
G
S
G
K
T
T
T
A
A
K
L
A
L
Y
Y
K
G
-
K
G
R
R
-
P
L
L
V
A
A
D
T
Q
R
P
A
A
R
E
Q
L
R
L
L
G
E
K
V
G
V
P
V
L
--
E
-
V
-
M
--
D
G
E-
S
-
P
E
S
I
R
R
R
V
E
E
K
A
R
L
E
A
R
D
L
I
L
V
D
T
A
G
R
L
Q
I
D
E
P
--
L
M
G
E
L
A
R
----
L
K
E
--
V
------
L
------
G
------
P
D
E
V
L
L
V
L
D
A
M
T
G
Q
E
A
L
S
V
A
R
A
F
D
E
K
V
G
-
V
T
G
L
V
L
T
K
L
D
G
D
A
R
G
G
A
A
L
S
A
R
H
V
T
G
K
P
I
Y
F
A
G
V
S
E
K
P
E
G
L
E
P
F
Y
P
E
R
L
A
G
R
I
L
G
M
G
D
V
A
S
L
A
E
K
V
R
A
A
----------------------
E
-
L
S
L
E
D
F
L
K
Q
M
Q
N
L
K
R
L
G
P
F
S
E
I
L
G
L
L
P
G
V
P
Q
G
---
L
K
----
V
D
E
-
K
A
-
I
K
R
L
E
A
I
V
L
S
M
T
P
E
E
R
K
D
P
R
I
L
-----
N
G
S
R
R
K
R
I
A
K
G
S
G
T
S
V
Q
E
V
N
R
F
I
K
A
F
E
E
M
K
A
L
M
K
S
L
E
K
------------------------------
6
PsiBlast_PDB
88.20
34%
-78
- C5 -
3DM5
10
SRP54_PYRFU
A:
[6-435]
----
L
G
K
A
L
A
N
T
L
K
K
I
--
A
R
A
------------
S
SV
D
E
A
L
I
K
E
L
V
R
D
I
Q
R
A
L
I
Q
A
D
V
N
V
R
L
V
L
Q
L
T
R
E
I
Q
R
R
A
L
E
-----
E
----
K
-----
P
P
A
-----
G
I
S
K
K
-----
E
--
H
I
I
K
-
I
------
V
Y
E
--
E
L
T
K
F
L
G
T
E
A
----
K
P
-------
I
---
E
I
-----
K
E
K
-------
P
T
I
L
L
M
V
G
I
Q
G
S
G
K
T
T
T
V
A
K
L
A
R
Y
F
Q
K
R
G
Y
-
K
-
V
G
V
V
C
S
D
T
W
R
P
G
A
Y
H
Q
L
R
Q
L
L
D
R
Y
H
I
E
V
F
G
-
N
-
P
-
Q
--
E
K
--
D
-
A
I
K
L
A
K
E
G
V
D
Y
F
K
S
K
G
V
D
I
I
I
V
D
T
A
G
R
H
K
E
D
K
A
--
L
I
E
E
M
K
Q
----
I
S
N
--
V
------
I
------
H
------
P
H
E
V
I
L
V
I
D
G
T
I
G
Q
Q
A
Y
N
Q
A
L
A
F
K
E
A
T
P
-
I
G
S
I
I
V
T
K
L
D
G
S
A
K
G
G
G
A
L
S
A
V
A
A
T
G
A
P
I
K
F
I
G
T
G
E
K
I
D
D
I
E
P
F
D
P
P
R
F
V
S
R
L
L
G
L
G
D
I
Q
G
L
L
E
K
F
K
E
L
-
E
K
E
V
E
-
I
K
E
E
D
I
E
R
F
L
---
R
G
K
-
F
T
L
K
D
M
Y
A
Q
L
E
A
M
R
K
M
G
P
-----------------------
I
S
I
G
E
E
R
L
K
K
F
K
V
I
M
D
S
M
T
E
E
E
L
L
N
P
E
I
I
-----
N
Y
S
R
I
K
R
I
A
R
G
S
G
T
S
T
K
D
V
K
E
L
L
D
Q
Y
R
Q
M
K
K
L
F
K
S
M
-
N
K
R
Q
L
---
S
----------------------
2
PsiBlast_PDB
86.91
40%
-75
- C5 -
2FFH
7
SRP54_THEAQ
A:
[1-418]
M
F
Q
Q
L
S
A
R
L
Q
E
A
I
G
R
L
--
R
G
R
------------
G
RI
T
E
E
D
L
K
A
T
L
R
E
I
R
R
A
L
M
D
A
D
V
N
L
E
V
T
R
D
F
V
E
R
V
-----
R
-----
E
----
E
-----
A
---------
L
G
K
-----
Q
VL
E
S
L
T
-
P
------
A
E
V
--
I
L
A
T
V
Y
E
A
L
K
----
E
A
--
L
---
G
G
---
E
A
-----
R
L
P
VLKD---
R
N
L
W
F
L
V
G
L
Q
G
S
G
K
T
T
T
A
A
K
L
A
L
Y
Y
K
G
K
G
R
-
R
-
P
L
L
V
A
A
D
T
Q
R
P
A
A
R
E
Q
L
R
L
L
G
E
K
V
G
V
P
V
L
--
E
V
M
-
D
--
G
E
--
S
-
P
E
S
I
R
R
R
V
E
E
K
A
R
L
E
A
R
D
L
I
L
V
D
T
A
G
R
L
Q
I
D
E
P
--
L
M
G
E
L
A
R
----
L
K
E
--
V
------
L
------
G
------
P
D
E
V
L
L
V
L
D
A
M
T
G
Q
E
A
L
S
V
A
R
A
F
D
E
K
V
G
-
V
T
G
L
V
L
T
K
L
D
G
D
A
R
G
G
A
A
L
S
A
R
H
V
T
G
K
P
I
Y
F
A
G
V
S
E
K
P
E
G
L
E
P
F
Y
P
E
R
L
A
G
R
I
L
G
M
G
D
V
A
S
L
A
E
K
V
R
A
A
---------------
E
L
--------
S
L
E
D
F
L
K
Q
M
Q
N
L
K
R
L
G
P
F
S
E
I
L
G
L
L
P
G
---
V
P
Q
G
L
K
-
V
-
D
E
K
A
----
I
K
R
L
E
A
I
V
L
S
M
T
P
E
E
R
K
D
P
R
I
L
-----
N
G
S
R
R
K
R
I
A
K
G
S
G
T
S
V
Q
E
V
N
R
F
I
K
A
F
E
E
M
K
A
L
M
K
S
L
E
K
------------------------------
23
PsiBlast_CBE
86.61
40%
-74
- C5 -
2FFH
7
SRP54_THEAQ
B:
[1-418]
M
F
Q
Q
L
S
A
R
L
Q
E
A
I
G
R
L
--
R
G
R
------------
G
RI
T
E
E
D
L
K
A
T
L
R
E
I
R
R
A
L
M
D
A
D
V
N
L
E
V
T
R
D
F
V
E
R
V
-----
R
-----
E
----
E
-----
A
---------
L
G
K
-----
Q
VL
E
S
L
T
-
P
------
A
E
V
--
I
L
A
T
V
Y
E
A
L
K
----
E
A
--
L
---
G
G
---
E
A
-----
R
L
P
VLKD---
R
N
L
W
F
L
V
G
L
Q
G
S
G
K
T
T
T
A
A
K
L
A
L
Y
Y
K
G
K
G
R
-
R
-
P
L
L
V
A
A
D
T
Q
R
P
A
A
R
E
Q
L
R
L
L
G
E
K
V
G
V
P
V
L
--
E
V
M
-
D
--
G
E
--
S
-
P
E
S
I
R
R
R
V
E
E
K
A
R
L
E
A
R
D
L
I
L
V
D
T
A
G
R
L
Q
I
D
E
P
--
L
M
G
E
L
A
R
----
L
K
E
--
V
------
L
------
G
------
P
D
E
V
L
L
V
L
D
A
M
T
G
Q
E
A
L
S
V
A
R
A
F
D
E
K
V
G
-
V
T
G
L
V
L
T
K
L
D
G
D
A
R
G
G
A
A
L
S
A
R
H
V
T
G
K
P
I
Y
F
A
G
V
S
E
K
P
E
G
L
E
P
F
Y
P
E
R
L
A
G
R
I
L
G
M
G
D
V
A
S
L
A
E
K
V
R
A
A
---------------
E
L
--------
S
L
E
D
F
L
K
Q
M
Q
N
L
K
R
L
G
P
F
S
E
I
L
G
L
L
P
G
---
V
P
Q
G
L
K
-
V
-
D
E
K
A
----
I
K
R
L
E
A
I
V
L
S
M
T
P
E
E
R
K
D
P
R
I
L
-----
N
G
S
R
R
K
R
I
A
K
G
S
G
T
S
V
Q
E
V
N
R
F
I
K
A
F
E
E
M
K
A
L
M
K
S
L
E
K
------------------------------
103
HHSearch
86.41
41%
-26
- C- -
2XXA
3
SRP54_ECOLI
A:
[4-432]
---
N
L
T
D
R
L
S
R
T
L
R
N
I
--
S
G
R
------------
G
RL
T
E
D
N
V
K
D
T
L
R
E
V
R
M
A
L
L
E
A
D
V
A
L
P
V
V
R
E
F
I
N
R
V
-----
K
-----
E
----
K
-----
A
V
G
HEVNK
S
L
T
P
G
-----
Q
--
E
F
V
K
-
I
------
V
R
N
--
E
L
V
A
A
M
G
E
-
E
----
N
Q
--
T
---
L
N
---
L
A
-----
A
Q
P
-------
P
A
V
V
L
M
A
G
L
Q
G
A
G
K
T
T
S
V
G
K
L
G
K
F
L
R
E
K
H
K
K
K
-
V
L
V
V
S
A
D
V
Y
R
P
A
A
I
K
Q
L
E
T
L
A
E
Q
V
G
V
D
F
F
--
P
-
S
-
D
--
V
G
Q-
K
-
P
V
D
I
V
N
A
A
L
K
E
A
K
L
K
F
Y
D
V
L
L
V
D
T
A
G
R
L
H
V
D
E
A
--
M
M
D
E
I
K
Q
----
V
H
A
--
S
------
I
------
N
------
P
V
E
T
L
F
V
V
D
A
M
T
G
Q
D
A
A
N
T
A
K
A
F
N
E
A
L
P
-
L
T
G
V
V
L
T
K
V
D
G
D
A
R
G
G
A
A
L
S
I
R
H
I
T
G
K
P
I
K
F
L
G
V
G
E
K
T
E
A
L
E
P
F
H
P
D
R
I
A
S
R
I
L
G
M
G
D
V
L
S
L
I
E
D
I
E
S
K
-
V
D
R
A
Q
-
A
E
--
K
L
A
S
K
L
K
K
-
G
D
G
-
F
D
L
N
D
F
L
E
Q
L
R
Q
M
K
N
M
G
G
M
A
S
L
M
G
K
-----------------
D
D
-
K
V
-
L
V
R
M
E
A
I
I
N
S
M
T
M
K
E
R
A
K
P
E
I
I
-----
K
G
S
R
K
R
R
I
A
A
G
S
G
M
Q
V
Q
D
V
N
R
L
L
K
Q
F
D
D
M
Q
R
M
M
K
K
M
K
K
------------------------------
24
PsiBlast_CBE
86.25
34%
-79
- C5 -
3DM5
9
SRP54_PYRFU
B:
[6-434]
----
L
G
K
A
L
A
N
T
L
K
K
I
--
A
R
A
------------
S
SV
D
E
A
L
I
K
E
L
V
R
D
I
Q
R
A
L
I
Q
A
D
V
N
V
R
L
V
L
Q
L
T
R
E
I
Q
R
R
A
L
E
-----
E
----
K
-----
P
P
A
-----
G
I
S
K
K
-----
E
--
H
I
I
K
-
I
------
V
Y
E
--
E
L
T
K
F
L
G
T
E
A
----
K
P
-------
I
---
E
I
-----
K
E
K
-------
P
T
I
L
L
M
V
G
I
Q
G
S
G
K
T
T
T
V
A
K
L
A
R
Y
F
Q
K
R
G
Y
-
K
-
V
G
V
V
C
S
D
T
W
R
P
G
A
Y
H
Q
L
R
Q
L
L
D
R
Y
H
I
E
V
F
G
-
N
-
P
-
Q
--
E
K
--
D
-
A
I
K
L
A
K
E
G
V
D
Y
F
K
S
K
G
V
D
I
I
I
V
D
T
A
G
R
H
K
E
D
K
A
--
L
I
E
-
M
K
Q
----
I
S
N
--
V
------
I
------
H
------
P
H
E
V
I
L
V
I
D
G
T
I
G
Q
Q
A
Y
N
Q
A
L
A
F
K
E
A
T
P
-
I
G
S
I
I
V
T
K
L
D
G
S
A
K
G
G
G
A
L
S
A
V
A
A
T
G
A
P
I
K
F
I
G
T
G
E
K
I
D
D
I
E
P
F
D
P
P
R
F
V
S
R
L
L
G
L
G
D
I
Q
G
L
L
E
K
F
K
E
L
-
E
K
E
V
E
-
I
K
E
E
D
I
E
R
F
L
---
R
G
K
-
F
T
L
K
D
M
Y
A
Q
L
E
A
M
R
K
M
G
P
------------------------
S
I
G
E
E
R
L
K
K
F
K
V
I
M
D
S
M
T
E
E
E
L
L
N
P
E
I
I
-----
N
Y
S
R
I
K
R
I
A
R
G
S
G
T
S
T
K
D
V
K
E
L
L
D
Q
Y
R
Q
M
K
K
L
F
K
S
M
-
N
K
R
Q
L
--------------------------
22
PsiBlast_CBE
85.73
40%
-72
- C5 -
2FFH
9
SRP54_THEAQ
C:
[1-418]
M
F
Q
Q
L
S
A
R
L
Q
E
A
I
G
R
L
--
R
G
R
------------
G
RI
T
E
E
D
L
K
A
T
L
R
E
I
R
R
A
L
M
D
A
D
V
N
L
E
V
T
R
D
F
V
E
R
V
-----
R
-----
E
----
E
-----
A
---------
L
G
K
-----
Q
VL
E
S
L
T
-
P
------
A
E
V
--
I
L
A
T
V
Y
E
A
L
K
----
E
A
--
L
---
G
G
---
E
A
-----
R
L
P
VLKD---
R
N
L
W
F
L
V
G
L
Q
G
S
G
K
T
T
T
A
A
K
L
A
L
Y
Y
K
G
K
G
R
-
R
-
P
L
L
V
A
A
D
T
Q
R
P
A
A
R
E
Q
L
R
L
L
G
E
K
V
G
V
P
V
L
--
E
V
M
-
D
--
G
E
--
S
-
P
E
S
I
R
R
R
V
E
E
K
A
R
L
E
A
R
D
L
I
L
V
D
T
A
G
R
L
Q
I
D
E
P
--
L
M
G
E
L
A
R
----
L
K
E
--
V
------
L
------
G
------
P
D
E
V
L
L
V
L
D
A
M
T
G
Q
E
A
L
S
V
A
R
A
F
D
E
K
V
G
-
V
T
G
L
V
L
T
K
L
D
G
D
A
R
G
G
A
A
L
S
A
R
H
V
T
G
K
P
I
Y
F
A
G
V
S
E
K
P
E
G
L
E
P
F
Y
P
E
R
L
A
G
R
I
L
G
M
G
D
V
A
S
L
A
E
K
V
R
A
A
---------------
E
L
--------
S
L
E
D
F
L
K
Q
M
Q
N
L
K
R
L
G
P
F
S
E
I
L
G
L
L
P
G
---
V
P
Q
G
L
K
-
V
-
D
E
K
A
----
I
K
R
L
E
A
I
V
L
S
M
T
P
E
E
R
K
D
P
R
I
L
-----
N
G
S
R
R
K
R
I
A
K
G
S
G
T
S
V
Q
E
V
N
R
F
I
K
A
F
E
E
M
K
A
L
M
K
S
L
E
K
------------------------------
5
PsiBlast_PDB
84.66
34%
-78
- C5 -
3NDB
1
SRP54_METJA
B:
[4-417]
----
L
G
E
N
L
N
K
A
L
N
K
L
--
K
A
A
------------
A
FV
D
K
K
L
I
K
E
V
I
K
D
I
Q
R
A
L
I
Q
A
D
V
N
V
K
L
V
L
K
M
S
K
E
I
-----
E
R
R
A
L
E
E
----
K
-----
T
P
K
-----
G
L
S
K
K
-----
E
--
H
I
I
K
-
I
------
V
Y
E
--
E
L
V
K
L
L
G
E
E
A
----
K
K
------
L
E
---
L
N
-----
P
K
K
-------
Q
N
V
I
L
L
V
G
I
Q
G
S
G
K
T
T
T
A
A
K
L
A
R
Y
I
Q
K
R
G
L
-
K
-
P
A
L
I
A
A
D
T
Y
R
P
A
A
Y
E
Q
L
K
Q
L
A
E
K
I
H
V
P
I
Y
--
G
-
D
-
E
TR
T
K
--
S
-
P
V
D
I
V
K
E
G
M
E
K
F
K
K
A
--
D
V
L
I
I
D
T
A
G
R
H
K
E
E
K
G
--
L
L
E
E
M
K
Q
----
I
K
E
--
I
------
T
------
N
------
P
D
E
I
I
L
V
I
D
G
T
I
G
Q
Q
A
G
I
Q
A
K
A
F
K
E
A
V
G
E
I
G
S
I
I
V
T
K
L
D
G
S
A
K
G
G
G
A
L
S
A
V
A
E
T
K
A
P
I
K
F
I
G
I
G
E
G
I
D
D
L
E
P
F
D
P
K
K
F
I
S
R
L
L
G
M
G
D
L
E
S
L
L
E
K
A
E
D
M
-
V
D
E
K
T
-
E
E
--
S
I
D
-
A
I
-
M
-
R
G
K
-
F
T
L
N
E
L
M
T
Q
L
E
A
I
E
N
M
--------------------------
L
T
E
A
K
-
I
K
K
Y
K
V
I
I
S
S
M
T
K
E
E
R
E
N
P
K
I
I
-----
K
A
S
R
I
R
R
I
A
R
G
S
G
T
T
E
N
D
V
R
E
V
L
R
Y
Y
E
T
T
K
N
A
I
D
K
L
R
K
G
L
A
L
---
A
L
L
L
L
L
L
A
L
A
L
------------
25
PsiBlast_CBE
82.52
40%
-92
- C5 -
4C7O
5
SRP54_ECOLI
C:
[2-298]
-
F
D
N
L
T
D
R
L
S
R
T
L
R
N
I
SG
R
G
R
------------
L
--
T
E
D
N
V
K
D
T
L
R
E
V
R
M
A
L
L
E
A
D
V
A
L
P
V
V
R
E
F
I
N
R
V
-----
K
-----
E
----
K
-----
A
V
G
-----
H
E
V
N
K
SLT
P
G
Q
--
E
F
V
K
-
I
------
V
R
N
--
E
L
V
A
A
M
G
E
E
N
----
Q
T
------
L
N
---
L
A
-----
A
Q
P
-------
P
A
V
V
L
M
A
G
L
Q
G
A
G
K
T
T
S
V
G
K
L
G
K
F
L
R
E
K
H
K
-
K
K
V
L
V
V
S
A
D
V
Y
R
P
A
A
I
K
Q
L
E
T
L
A
E
Q
V
G
V
D
F
F
--
P
-
S
-
D
V-
G
Q
--
K
-
P
V
D
I
V
N
A
A
L
K
E
A
K
L
K
F
Y
D
V
L
L
V
D
T
A
G
R
L
H
V
D
E
A
--
M
M
D
E
I
K
Q
----
V
H
A
--
S
------
I
------
N
------
P
V
E
T
L
F
V
V
D
A
M
T
G
Q
D
A
A
N
T
A
K
A
F
N
E
A
L
P
-
L
T
G
V
V
L
T
K
V
D
G
D
A
R
G
G
A
A
L
S
I
R
H
I
T
G
K
P
I
K
F
L
G
V
G
E
K
T
E
A
L
E
P
F
H
P
D
R
I
A
S
R
I
L
G
M
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
82.32
34%
-67
- C5 -
2V3C
-
SRP54_METJA
C:
[5-418]
----
L
G
E
N
L
N
K
A
L
N
K
L
--
K
A
A
------------
A
FV
D
K
K
L
I
K
E
V
I
K
D
I
Q
R
A
L
I
Q
A
D
V
N
V
K
L
V
L
K
M
S
K
E
I
-----
E
RRALE
E
----
K
-----
T
P
K
-----
G
L
S
K
K
-----
E
--
H
I
I
K
-
I
------
V
Y
E
--
E
L
V
K
L
L
G
E
E
A
----
K
K
------
L
E
---
L
N
-----
P
K
K
-------
Q
N
V
I
L
L
V
G
I
Q
G
S
G
K
T
T
T
A
A
K
L
A
R
Y
I
Q
K
R
G
L
-
K
-
P
A
L
I
A
A
D
T
Y
R
P
A
A
Y
E
Q
L
K
Q
L
A
E
K
I
H
V
P
I
Y
--
G
-
D
-
E
TR
T
K
--
S
-
P
V
D
I
V
K
E
G
M
E
K
F
K
K
A
--
D
V
L
I
I
D
T
A
G
R
H
K
E
E
K
G
--
L
L
E
E
M
K
Q
----
I
K
E
--
I
------
T
------
N
------
P
D
E
I
I
L
V
I
D
G
T
I
G
Q
Q
A
G
I
Q
A
K
A
F
K
E
A
V
G
E
I
G
S
I
I
V
T
K
L
D
G
S
A
K
G
G
G
A
L
S
A
V
A
E
T
K
A
P
I
K
F
I
G
I
G
E
G
I
D
D
L
E
P
F
D
P
K
K
F
I
S
R
L
L
G
M
G
D
L
E
S
L
L
E
K
A
E
D
M
-
V
D
E
K
T
-
E
E
--
S
I
D
-
A
I
-
M
-
R
G
K
-
F
T
L
N
E
L
M
T
Q
L
E
A
I
E
N
M
--------------------------
L
T
E
A
K
-
I
K
K
Y
K
V
I
I
S
S
M
T
K
E
E
R
E
N
P
K
I
I
-----
K
A
S
R
I
R
R
I
A
R
G
S
G
T
T
E
N
D
V
R
E
V
L
R
Y
Y
E
T
T
K
N
A
I
D
K
L
H
-------------------------------
9
PsiBlast_PDB
81.69
40%
-96
- C5 -
4C7O
4
SRP54_ECOLI
A:
[4-296]
---
N
L
T
D
R
L
S
R
T
L
R
N
I
SG
R
G
R
------------
L
--
T
E
D
N
V
K
D
T
L
R
E
V
R
M
A
L
L
E
A
D
V
A
L
P
V
V
R
E
F
I
N
R
V
-----
K
-----
E
----
K
-----
A
V
G
-----
H
E
V
N
K
SLT
P
G
Q
--
E
F
V
K
-
I
------
V
R
N
--
E
L
V
A
A
M
G
E
E
N
----
Q
T
------
L
N
---
L
A
-----
A
Q
P
-------
P
A
V
V
L
M
A
G
L
Q
G
A
G
K
T
T
S
V
G
K
L
G
K
F
L
R
E
K
H
K
-
K
K
V
L
V
V
S
A
D
V
Y
R
P
A
A
I
K
Q
L
E
T
L
A
E
Q
V
G
V
D
F
F
--
P
-
S
-
D
V-
G
Q
--
K
-
P
V
D
I
V
N
A
A
L
K
E
A
K
L
K
F
Y
D
V
L
L
V
D
T
A
G
R
L
H
V
D
E
A
--
M
M
D
E
I
K
Q
----
V
H
A
--
S
------
I
------
N
------
P
V
E
T
L
F
V
V
D
A
M
T
G
Q
D
A
A
N
T
A
K
A
F
N
E
A
L
P
-
L
T
G
V
V
L
T
K
V
D
G
D
A
R
G
G
A
A
L
S
I
R
H
I
T
G
K
P
I
K
F
L
G
V
G
E
K
T
E
A
L
E
P
F
H
P
D
R
I
A
S
R
I
L
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
81.14
31%
-64
- C5 -
2J37
1
SRP54_CANFA
W:
[24-465]
------------------------------------
N
E
E
V
L
N
A
M
L
K
E
V
C
T
A
L
L
E
A
D
V
N
I
K
L
V
K
Q
L
R
E
N
V
-----
K
-----
S
AIDL
E
-----
E
M
A
-----
S
G
L
N
K
-----
R
--
K
M
I
Q
H
A
------
V
F
K
--
E
L
V
K
L
V
D
P
-
G
----
V
K
--
A
---
W
T
---
P
T
-----
K
G
---------
N
V
I
M
F
V
G
L
Q
G
S
G
K
T
T
T
C
S
K
L
A
Y
Y
Y
Q
R
K
G
W
-
K
-
T
C
L
I
C
A
D
T
F
R
A
G
A
F
D
Q
L
K
Q
N
A
T
K
A
R
I
P
F
Y
GS
Y
-
T
-
E
--
M
D
--
P
-
V
I
-
I
A
S
E
G
V
E
K
F
K
N
E
N
F
E
I
I
I
V
D
T
S
G
R
H
K
Q
E
D
S
--
L
F
E
E
M
L
Q
----
V
A
N
--
A
------
I
------
Q
------
P
D
N
I
V
Y
V
M
D
A
S
I
G
Q
A
C
E
A
Q
A
K
A
F
K
D
K
V
D
-
V
A
S
V
I
V
T
K
L
D
G
H
A
K
G
G
G
A
L
S
A
V
A
A
T
K
S
P
I
I
F
I
G
T
G
E
H
I
D
D
F
E
P
F
K
T
Q
P
F
I
S
K
L
L
G
M
G
D
I
E
G
L
I
D
K
V
N
E
L
K
L
D
D
N
E
-
A
----
L
I
E
K
L
-
K
-
H
G
Q
-
F
T
L
R
D
M
Y
E
Q
F
Q
N
I
M
K
M
G
P
F
S
Q
I
L
G
M
I
P
G
F
G
T
D
F
M
S
-
K
G
N
-
E
Q
E
S
M
A
R
-
L
K
K
L
M
T
I
M
D
S
M
N
D
Q
E
L
D
S
T
D
G
A
KVFSK
Q
P
G
R
I
Q
R
V
A
R
G
S
G
V
S
T
R
D
V
Q
E
L
L
T
Q
Y
T
K
F
A
Q
M
V
K
K
M
G
G
I
K
G
L
FKG
G
D
M
S
K
N
V
S
Q
S
Q
MAKL
N
Q
Q
M
A
K
M
M
8
PsiBlast_PDB
80.54
36%
-74
- C5 -
1QZX
-
SRP54_SULSO
A:
[20-408]
-------------------------------------
E
K
A
V
D
E
F
I
K
D
L
Q
K
S
L
I
S
S
D
V
N
V
K
L
V
F
S
L
T
A
K
I
-----
K
-----
E
----
R
---------------
L
N
K
-----
E
--
K
P
P
S
-
V
------
L
E
R
K
E
W
F
I
S
I
V
Y
D
E
L
----
S
K
--
L
---
F
G
---
G
D
-----
K
E
P
NVNPTKL
P
F
I
I
M
L
V
G
V
Q
G
S
G
K
T
T
T
A
G
K
L
A
Y
F
Y
K
K
R
G
Y
-
K
-
V
G
L
V
A
A
D
V
Y
R
P
A
A
Y
D
Q
L
L
Q
L
G
N
Q
I
G
V
Q
V
Y
--
G
-
E
P
N
--
N
Q
--
N
-
P
I
E
I
A
K
K
G
V
D
I
F
V
K
N
K
M
D
I
I
I
V
D
T
A
G
R
H
G
Y
G
E
E
T
K
L
L
E
E
M
K
E
----
M
Y
D
--
V
------
L
------
K
------
P
D
D
V
I
L
V
I
D
A
S
I
G
Q
K
A
Y
D
L
A
S
R
F
H
Q
A
S
P
-
I
G
S
V
I
I
T
K
M
D
G
T
A
K
G
G
G
A
L
S
A
V
V
A
T
G
A
T
I
K
F
I
G
T
G
E
K
I
D
E
L
E
T
F
N
A
K
R
F
V
S
R
I
L
G
M
G
D
I
E
S
I
L
E
K
V
K
G
L
----
E
E
-
Y
D
--
K
I
Q
K
K
M
-
E
D----
L
T
L
R
D
V
Y
A
Q
I
I
A
L
R
K
M
G
P
L
S
K
V
L
Q
H
I
P
G
L
G
I
M
L
P
T
P
S
E
D
-
Q
L
K
I
G
E
E
K
I
R
R
W
L
A
A
L
N
S
M
T
Y
K
E
L
E
N
P
N
I
I
-----
D
K
S
R
M
R
R
I
A
E
G
S
G
L
E
V
E
E
V
R
E
L
L
E
W
Y
N
N
M
N
R
L
L
K
M
V
K
-------------------------------
26
PsiBlast_CBE
78.81
40%
-86
- C5 -
2J46
5
SRP54_THEAQ
B:
[1-297]
M
F
Q
Q
L
S
A
R
L
Q
E
A
I
G
R
L
--
R
G
R
------------
G
RI
T
E
E
D
L
K
A
T
L
R
E
I
R
R
A
L
M
D
A
D
V
N
L
E
V
A
R
D
F
V
E
R
V
-----
R
-----
E
----
E
-----
A
---------
L
G
K
-----
Q
VL
E
S
L
T
-
P
------
A
E
V
--
I
L
A
T
V
Y
E
A
L
K
----
E
A
--
L
---
G
G
---
E
A
-----
R
L
P
VLKD---
R
N
L
W
F
L
V
G
L
Q
G
S
G
K
T
T
T
A
A
K
L
A
L
Y
Y
K
G
K
G
R
-
R
-
P
L
L
V
A
A
D
T
Q
R
P
A
A
R
E
Q
L
R
L
L
G
E
K
V
G
V
P
V
L
--
E
V
M
-
D
--
G
E
--
S
-
P
E
S
I
R
R
R
V
E
E
K
A
R
L
E
A
R
D
L
I
L
V
D
T
A
G
R
L
Q
I
D
E
P
--
L
M
G
E
L
A
R
----
L
K
E
--
V
------
L
------
G
------
P
D
E
V
L
L
V
L
D
A
M
T
G
Q
E
A
L
S
V
A
R
A
F
D
E
K
V
G
-
V
T
G
L
V
L
T
K
L
D
G
D
A
R
G
G
A
A
L
S
A
R
H
V
T
G
K
P
I
Y
F
A
G
V
S
E
K
P
E
G
L
E
P
F
Y
P
E
R
L
A
G
R
I
L
G
M
G
D
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
78.78
40%
-81
- C5 -
1O87
7
SRP54_THEAQ
B:
[1-295]
M
F
Q
Q
L
S
A
R
L
Q
E
A
I
G
R
L
--
R
G
R
------------
G
RI
T
E
E
D
L
K
A
T
L
R
E
I
R
R
A
L
M
D
A
D
V
N
L
E
V
A
R
D
F
V
E
R
V
-----
R
-----
E
----
E
-----
A
---------
L
G
K
-----
Q
VL
E
S
L
T
-
P
------
A
E
V
--
I
L
A
T
V
Y
E
A
L
K
----
E
A
--
L
---
G
G
---
E
A
-----
R
L
P
VLKD---
R
N
L
W
F
L
V
G
L
Q
G
S
G
K
T
T
T
A
A
K
L
A
L
Y
Y
K
G
K
G
R
-
R
-
P
L
L
V
A
A
D
T
Q
R
P
A
A
R
E
Q
L
R
L
L
G
E
K
V
G
V
P
V
L
--
E
V
M
-
D
--
G
E
--
S
-
P
E
S
I
R
R
R
V
E
E
K
A
R
L
E
A
R
D
L
I
L
V
D
T
A
G
R
L
Q
I
D
E
P
--
L
M
G
E
L
A
R
----
L
K
E
--
V
------
L
------
G
------
P
D
E
V
L
L
V
L
D
A
M
T
G
Q
E
A
L
S
V
A
R
A
F
D
E
K
V
G
-
V
T
G
L
V
L
T
K
L
D
G
D
A
R
G
G
A
A
L
S
A
R
H
V
T
G
K
P
I
Y
F
A
G
V
S
E
K
P
E
G
L
E
P
F
Y
P
E
R
L
A
G
R
I
L
G
M
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
108
HHSearch
78.76
34%
-44
- C- -
2V3C
-
SRP54_METJA
C:
[2-428]
-
M
D
K
L
G
E
N
L
N
K
A
L
N
K
L
--
K
A
A
------------
A
FV
D
K
K
L
I
K
E
V
I
K
D
I
Q
R
A
L
I
Q
A
D
V
N
V
K
L
V
L
K
M
S
K
E
I
-----
E
-----
R
----
R
-----
A
L
E
EKTPK
G
L
S
K
K
-----
E
--
H
I
I
K
-
I
------
V
Y
E
--
E
L
V
K
L
L
G
E
-
E
----
A
K
--
K
---
L
E
---
L
N
-----
P
K
K
-------
Q
N
V
I
L
L
V
G
I
Q
G
S
G
K
T
T
T
A
A
K
L
A
R
Y
I
Q
K
-
R
G
L
K
-
P
A
L
I
A
A
D
T
Y
R
P
A
A
Y
E
Q
L
K
Q
L
A
E
K
I
H
V
P
I
Y
--
G
-
D
-
E
--
T
R
TK
S
-
P
V
D
I
V
K
E
G
M
E
K
F
--
K
K
A
D
V
L
I
I
D
T
A
G
R
H
K
E
E
K
G
--
L
L
E
E
M
K
Q
----
I
K
E
--
I
------
T
------
N
------
P
D
E
I
I
L
V
I
D
G
T
I
G
Q
Q
A
G
I
Q
A
K
A
F
K
E
A
V
G
E
I
G
S
I
I
V
T
K
L
D
G
S
A
K
G
G
G
A
L
S
A
V
A
E
T
K
A
P
I
K
F
I
G
I
G
E
G
I
D
D
L
E
P
F
D
P
K
K
F
I
S
R
L
L
G
M
G
D
L
E
S
L
L
E
K
A
E
D
M
-
V
D
E
K
--
T
E
--
E
S
I
D
A
I
-
M
-
R
G
K
-
F
T
L
N
E
L
M
T
Q
L
E
A
I
E
N
M
-------------------------
L
T
E
-
A
K
-
I
K
K
Y
K
V
I
I
S
S
M
T
K
E
E
R
E
N
P
K
I
I
-----
K
A
S
R
I
R
R
I
A
R
G
S
G
T
T
E
N
D
V
R
E
V
L
R
Y
Y
E
T
T
K
N
A
I
D
K
L
H
-------------------------------
32
PsiBlast_CBE
78.41
40%
-87
- C5 -
3NG1
7
SRP54_THEAQ
B:
[1-293]
M
F
Q
Q
L
S
A
R
L
Q
E
A
I
G
R
L
--
R
G
R
------------
G
RI
T
E
E
D
L
K
A
T
L
R
E
I
R
R
A
L
M
D
A
D
V
N
L
E
V
A
R
D
F
V
E
R
V
-----
R
-----
E
----
E
-----
A
---------
L
G
K
-----
Q
VL
E
S
L
T
-
P
------
A
E
V
--
I
L
A
T
V
Y
E
A
L
K
----
E
A
--
L
---
G
G
---
E
A
-----
R
L
P
VLKD---
R
N
L
W
F
L
V
G
L
Q
G
S
G
K
T
T
T
A
A
K
L
A
L
Y
Y
K
G
K
G
R
-
R
-
P
L
L
V
A
A
D
T
Q
R
P
A
A
R
E
Q
L
R
L
L
G
E
K
V
G
V
P
V
L
--
E
V
M
-
D
--
G
E
--
S
-
P
E
S
I
R
R
R
V
E
E
K
A
R
L
E
A
R
D
L
I
L
V
D
T
A
G
R
L
Q
I
D
E
P
--
L
M
G
E
L
A
R
----
L
K
E
--
V
------
L
------
G
------
P
D
E
V
L
L
V
L
D
A
M
T
G
Q
E
A
L
S
V
A
R
A
F
D
E
K
V
G
-
V
T
G
L
V
L
T
K
L
D
G
D
A
R
G
G
A
A
L
S
A
R
H
V
T
G
K
P
I
Y
F
A
G
V
S
E
K
P
E
G
L
E
P
F
Y
P
E
R
L
A
G
R
I
L
G
M
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
78.39
40%
-84
- C5 -
1JPN
4
SRP54_THEAQ
B:
[1-295]
M
F
Q
Q
L
S
A
R
L
Q
E
A
I
G
R
L
--
R
G
R
------------
G
RI
T
E
E
D
L
K
A
T
L
R
E
I
R
R
A
L
M
D
A
D
V
N
L
E
V
A
R
D
F
V
E
R
V
-----
R
-----
E
----
E
-----
A
---------
L
G
K
-----
Q
VL
E
S
L
T
-
P
------
A
E
V
--
I
L
A
T
V
Y
E
A
L
K
----
E
A
--
L
---
G
G
---
E
A
-----
R
L
P
VLKD---
R
N
L
W
F
L
V
G
L
Q
G
S
G
K
T
T
T
A
A
K
L
A
L
Y
Y
K
G
K
G
R
-
R
-
P
L
L
V
A
A
D
T
Q
R
P
A
A
R
E
Q
L
R
L
L
G
E
K
V
G
V
P
V
L
--
E
V
M
-
D
--
G
E
--
S
-
P
E
S
I
R
R
R
V
E
E
K
A
R
L
E
A
R
D
L
I
L
V
D
T
A
G
R
L
Q
I
D
E
P
--
L
M
G
E
L
A
R
----
L
K
E
--
V
------
L
------
G
------
P
D
E
V
L
L
V
L
D
A
M
T
G
Q
E
A
L
S
V
A
R
A
F
D
E
K
V
G
-
V
T
G
L
V
L
T
K
L
D
G
D
A
R
G
G
A
A
L
S
A
R
H
V
T
G
K
P
I
Y
F
A
G
V
S
E
K
P
E
G
L
E
P
F
Y
P
E
R
L
A
G
R
I
L
G
M
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
78.29
40%
-81
- C5 -
1JPJ
1
SRP54_THEAQ
A:
[1-294]
M
F
Q
Q
L
S
A
R
L
Q
E
A
I
G
R
L
--
R
G
R
------------
G
RI
T
E
E
D
L
K
A
T
L
R
E
I
R
R
A
L
M
D
A
D
V
N
L
E
V
A
R
D
F
V
E
R
V
-----
R
-----
E
----
E
-----
A
---------
L
G
K
-----
Q
VL
E
S
L
T
-
P
------
A
E
V
--
I
L
A
T
V
Y
E
A
L
K
----
E
A
--
L
---
G
G
---
E
A
-----
R
L
P
VLKD---
R
N
L
W
F
L
V
G
L
Q
G
S
G
K
T
T
T
A
A
K
L
A
L
Y
Y
K
G
K
G
R
-
R
-
P
L
L
V
A
A
D
T
Q
R
P
A
A
R
E
Q
L
R
L
L
G
E
K
V
G
V
P
V
L
--
E
V
M
-
D
--
G
E
--
S
-
P
E
S
I
R
R
R
V
E
E
K
A
R
L
E
A
R
D
L
I
L
V
D
T
A
G
R
L
Q
I
D
E
P
--
L
M
G
E
L
A
R
----
L
K
E
--
V
------
L
------
G
------
P
D
E
V
L
L
V
L
D
A
M
T
G
Q
E
A
L
S
V
A
R
A
F
D
E
K
V
G
-
V
T
G
L
V
L
T
K
L
D
G
D
A
R
G
G
A
A
L
S
A
R
H
V
T
G
K
P
I
Y
F
A
G
V
S
E
K
P
E
G
L
E
P
F
Y
P
E
R
L
A
G
R
I
L
G
M
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
78.16
40%
-87
- C5 -
3NG1
6
SRP54_THEAQ
A:
[1-293]
M
F
Q
Q
L
S
A
R
L
Q
E
A
I
G
R
L
--
R
G
R
------------
G
RI
T
E
E
D
L
K
A
T
L
R
E
I
R
R
A
L
M
D
A
D
V
N
L
E
V
A
R
D
F
V
E
R
V
-----
R
-----
E
----
E
-----
A
---------
L
G
K
-----
Q
VL
E
S
L
T
-
P
------
A
E
V
--
I
L
A
T
V
Y
E
A
L
K
----
E
A
--
L
---
G
G
---
E
A
-----
R
L
P
VLKD---
R
N
L
W
F
L
V
G
L
Q
G
S
G
K
T
T
T
A
A
K
L
A
L
Y
Y
K
G
K
G
R
-
R
-
P
L
L
V
A
A
D
T
Q
R
P
A
A
R
E
Q
L
R
L
L
G
E
K
V
G
V
P
V
L
--
E
V
M
-
D
--
G
E
--
S
-
P
E
S
I
R
R
R
V
E
E
K
A
R
L
E
A
R
D
L
I
L
V
D
T
A
G
R
L
Q
I
D
E
P
--
L
M
G
E
L
A
R
----
L
K
E
--
V
------
L
------
G
------
P
D
E
V
L
L
V
L
D
A
M
T
G
Q
E
A
L
S
V
A
R
A
F
D
E
K
V
G
-
V
T
G
L
V
L
T
K
L
D
G
D
A
R
G
G
A
A
L
S
A
R
H
V
T
G
K
P
I
Y
F
A
G
V
S
E
K
P
E
G
L
E
P
F
Y
P
E
R
L
A
G
R
I
L
G
M
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
PsiBlast_CBE
77.93
40%
-85
- C5 -
1NG1
13
SRP54_THEAQ
A:
[1-293]
M
F
Q
Q
L
S
A
R
L
Q
E
A
I
G
R
L
--
R
G
R
------------
G
RI
T
E
E
D
L
K
A
T
L
R
E
I
R
R
A
L
M
D
A
D
V
N
L
E
V
A
R
D
F
V
E
R
V
-----
R
-----
E
----
E
-----
A
---------
L
G
K
-----
Q
VL
E
S
L
T
-
P
------
A
E
V
--
I
L
A
T
V
Y
E
A
L
K
----
E
A
--
L
---
G
G
---
E
A
-----
R
L
P
V
L
K
D---
R
N
L
W
F
L
V
G
L
Q
G
S
G
K
T
T
T
A
A
K
L
A
L
Y
Y
K
G
K
G
R
-
R
-
P
L
L
V
A
A
D
T
Q
R
P
A
A
R
E
Q
L
R
L
L
G
E
K
V
G
V
P
V
L
--
E
V
M
-
D
--
G
E
--
S
-
P
E
S
I
R
R
R
V
E
E
K
A
R
L
E
A
R
D
L
I
L
V
D
T
A
G
R
L
Q
I
D
E
P
--
L
M
G
E
L
A
R
----
L
K
E
--
V
------
L
------
G
------
P
D
E
V
L
L
V
L
D
A
M
T
G
Q
E
A
L
S
V
A
R
A
F
D
E
K
V
G
-
V
T
G
L
V
L
T
K
L
D
G
D
A
R
G
G
A
A
L
S
A
R
H
V
T
G
K
P
I
Y
F
A
G
V
S
E
K
P
E
G
L
E
P
F
Y
P
E
R
L
A
G
R
I
L
G
M
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
77.76
40%
-80
- C5 -
1OKK
17
SRP54_THEAQ
A:
[4-293]
---
Q
L
S
A
R
L
Q
E
A
I
G
R
L
--
R
G
R
------------
G
RI
T
E
E
D
L
K
A
T
L
R
E
I
R
R
A
L
M
D
A
D
V
N
L
E
V
A
R
D
F
V
E
R
V
-----
R
-----
E
----
E
-----
A
---------
L
G
K
-----
Q
VL
E
S
L
T
-
P
------
A
E
V
--
I
L
A
T
V
Y
E
A
L
K
----
E
A
--
L
---
G
G
---
E
A
-----
R
L
P
VLKD---
R
N
L
W
F
L
V
G
L
Q
G
S
G
K
T
T
T
A
A
K
L
A
L
Y
Y
K
G
K
G
R
-
R
-
P
L
L
V
A
A
D
T
Q
R
P
A
A
R
E
Q
L
R
L
L
G
E
K
V
G
V
P
V
L
--
E
V
M
-
D
--
G
E
--
S
-
P
E
S
I
R
R
R
V
E
E
K
A
R
L
E
A
R
D
L
I
L
V
D
T
A
G
R
L
Q
I
D
E
P
--
L
M
G
E
L
A
R
----
L
K
E
--
V
------
L
------
G
------
P
D
E
V
L
L
V
L
D
A
M
T
G
Q
E
A
L
S
V
A
R
A
F
D
E
K
V
G
-
V
T
G
L
V
L
T
K
L
D
G
D
A
R
G
G
A
A
L
S
A
R
H
V
T
G
K
P
I
Y
F
A
G
V
S
E
K
P
E
G
L
E
P
F
Y
P
E
R
L
A
G
R
I
L
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
77.72
40%
-85
- C5 -
1JPN
4
SRP54_THEAQ
A:
[1-296]
M
F
Q
Q
L
S
A
R
L
Q
E
A
I
G
R
L
--
R
G
R
------------
G
RI
T
E
E
D
L
K
A
T
L
R
E
I
R
R
A
L
M
D
A
D
V
N
L
E
V
A
R
D
F
V
E
R
V
-----
R
-----
E
----
E
-----
A
---------
L
G
K
-----
Q
VL
E
S
L
T
-
P
------
A
E
V
--
I
L
A
T
V
Y
E
A
L
K
----
E
A
--
L
---
G
G
---
E
A
-----
R
L
P
VLKD---
R
N
L
W
F
L
V
G
L
Q
G
S
G
K
T
T
T
A
A
K
L
A
L
Y
Y
K
G
K
G
R
-
R
-
P
L
L
V
A
A
D
T
Q
R
P
A
A
R
E
Q
L
R
L
L
G
E
K
V
G
V
P
V
L
--
E
V
M
-
D
--
G
E
--
S
-
P
E
S
I
R
R
R
V
E
E
K
A
R
L
E
A
R
D
L
I
L
V
D
T
A
G
R
L
Q
I
D
E
P
--
L
M
G
E
L
A
R
----
L
K
E
--
V
------
L
------
G
------
P
D
E
V
L
L
V
L
D
A
M
T
G
Q
E
A
L
S
V
A
R
A
F
D
E
K
V
G
-
V
T
G
L
V
L
T
K
L
D
G
D
A
R
G
G
A
A
L
S
A
R
H
V
T
G
K
P
I
Y
F
A
G
V
S
E
K
P
E
G
L
E
P
F
Y
P
E
R
L
A
G
R
I
L
G
M
G
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
77.29
40%
-85
- C5 -
1O87
7
SRP54_THEAQ
A:
[1-295]
M
F
Q
Q
L
S
A
R
L
Q
E
A
I
G
R
L
--
R
G
R
------------
G
RI
T
E
E
D
L
K
A
T
L
R
E
I
R
R
A
L
M
D
A
D
V
N
L
E
V
A
R
D
F
V
E
R
V
-----
R
-----
E
----
E
-----
A
---------
L
G
K
-----
Q
VL
E
S
L
T
-
P
------
A
E
V
--
I
L
A
T
V
Y
E
A
L
K
----
E
A
--
L
---
G
G
---
E
A
-----
R
L
P
VLKD---
R
N
L
W
F
L
V
G
L
Q
G
S
G
K
T
T
T
A
A
K
L
A
L
Y
Y
K
G
K
G
R
-
R
-
P
L
L
V
A
A
D
T
Q
R
P
A
A
R
E
Q
L
R
L
L
G
E
K
V
G
V
P
V
L
--
E
V
M
-
D
--
G
E
--
S
-
P
E
S
I
R
R
R
V
E
E
K
A
R
L
E
A
R
D
L
I
L
V
D
T
A
G
R
L
Q
I
D
E
P
--
L
M
G
E
L
A
R
----
L
K
E
--
V
------
L
------
G
------
P
D
E
V
L
L
V
L
D
A
M
T
G
Q
E
A
L
S
V
A
R
A
F
D
E
K
V
G
-
V
T
G
L
V
L
T
K
L
D
G
D
A
R
G
G
A
A
L
S
A
R
H
V
T
G
K
P
I
Y
F
A
G
V
S
E
K
P
E
G
L
E
P
F
Y
P
E
R
L
A
G
R
I
L
G
M
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
77.09
40%
-77
- C5 -
2J7P
11
SRP54_THEAQ
A:
[3-293]
--
Q
Q
L
S
A
R
L
Q
E
A
I
G
R
L
--
R
G
R
------------
G
RI
T
E
E
D
L
K
A
T
L
R
E
I
R
R
A
L
M
D
A
D
V
N
L
E
V
A
R
D
F
V
E
R
V
-----
R
-----
E
----
E
-----
A
---------
L
G
K
-----
Q
VL
E
S
L
T
-
P
------
A
E
V
--
I
L
A
T
V
Y
E
A
L
K
----
E
A
--
L
---
G
G
---
E
A
-----
R
L
P
V
L
K
D---
R
N
L
W
F
L
V
G
L
Q
G
S
G
K
T
T
T
A
A
K
L
A
L
Y
Y
K
G
K
G
R
-
R
-
P
L
L
V
A
A
D
T
Q
R
P
A
A
R
E
Q
L
R
L
L
G
E
K
V
G
V
P
V
L
--
E
V
M
-
D
--
G
E
--
S
-
P
E
S
I
R
R
R
V
E
E
K
A
R
L
E
A
R
D
L
I
L
V
D
T
A
G
R
L
Q
I
D
E
P
--
L
M
G
E
L
A
R
----
L
K
E
--
V
------
L
------
G
------
P
D
E
V
L
L
V
L
D
A
M
T
G
Q
E
A
L
S
V
A
R
A
F
D
E
K
V
G
-
V
T
G
L
V
L
T
K
L
D
G
D
A
R
G
G
A
A
L
S
A
R
H
V
T
G
K
P
I
Y
F
A
G
V
S
E
K
P
E
G
L
E
P
F
Y
P
E
R
L
A
G
R
I
L
G
M
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
76.76
40%
-80
- C5 -
2J7P
8
SRP54_THEAQ
B:
[4-293]
---
Q
L
S
A
R
L
Q
E
A
I
G
R
L
--
R
G
R
------------
G
RI
T
E
E
D
L
K
A
T
L
R
E
I
R
R
A
L
M
D
A
D
V
N
L
E
V
A
R
D
F
V
E
R
V
-----
R
-----
E
----
E
-----
A
---------
L
G
K
-----
Q
VL
E
S
L
T
-
P
------
A
E
V
--
I
L
A
T
V
Y
E
A
L
K
----
E
A
--
L
---
G
G
---
E
A
-----
R
L
P
VLKD---
R
N
L
W
F
L
V
G
L
Q
G
S
G
K
T
T
T
A
A
K
L
A
L
Y
Y
K
G
K
G
R
-
R
-
P
L
L
V
A
A
D
T
Q
R
P
A
A
R
E
Q
L
R
L
L
G
E
K
V
G
V
P
V
L
--
E
V
M
-
D
--
G
E
--
S
-
P
E
S
I
R
R
R
V
E
E
K
A
R
L
E
A
R
D
L
I
L
V
D
T
A
G
R
L
Q
I
D
E
P
--
L
M
G
E
L
A
R
----
L
K
E
--
V
------
L
------
G
------
P
D
E
V
L
L
V
L
D
A
M
T
G
Q
E
A
L
S
V
A
R
A
F
D
E
K
V
G
-
V
T
G
L
V
L
T
K
L
D
G
D
A
R
G
G
A
A
L
S
A
R
H
V
T
G
K
P
I
Y
F
A
G
V
S
E
K
P
E
G
L
E
P
F
Y
P
E
R
L
A
G
R
I
L
G
M
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
114
HHSearch
76.69
35%
-91
- C5 -
3E70
3
?
C:
[7-324]
M
F
G
K
L
R
E
K
L
K
S
F
V
K
R
V
--
E
E
E
VEKEEEEVILTV
E
I-
K
E
K
D
V
D
K
A
L
D
E
L
E
I
D
L
L
E
A
D
V
A
L
E
V
V
D
A
L
R
E
K
I
-----
K
-----
Q
----
K
-----
L
V
G
KKVRI
G
---
G
-----
K
--
I
I
E
E
-
A
------
V
K
E
--
A
V
S
E
I
L
E
T
------
S
R
--
R
IDL
I
E
EI-
R
K
-----
A
E
K
-------
P
Y
V
I
M
F
V
G
F
N
G
S
G
K
T
T
T
I
A
K
L
A
N
W
L
K
N
-
H
G
F
S
-
V
V
I
A
A
S
D
T
F
R
A
G
A
I
E
Q
L
E
E
H
A
K
R
I
G
V
K
V
I
--
K
-
H
-
S
--
Y
G
A-
D
-
P
A
A
V
A
Y
D
A
I
Q
H
A
K
A
R
G
I
D
V
V
L
I
D
T
A
G
R
S
E
T
N
R
N
--
L
M
D
E
M
K
K
----
I
A
R
--
V
------
T
------
K
------
P
N
L
V
I
F
V
G
D
A
L
A
G
N
A
I
V
E
Q
A
R
Q
F
N
E
A
V
K
-
I
D
G
I
I
L
T
K
L
D
A
D
A
R
G
G
A
A
L
S
I
S
Y
V
I
D
A
P
I
L
F
V
G
V
G
Q
G
Y
D
D
L
R
P
F
E
K
E
W
F
L
E
R
I
F
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
PsiBlast_CBE
76.14
39%
-82
- C5 -
2NG1
4
SRP54_THEAQ
A:
[1-292]
-
F
Q
Q
L
S
A
R
L
Q
E
A
I
G
R
L
--
R
G
R
------------
G
RI
T
E
E
D
L
K
A
T
L
R
E
I
R
R
A
L
M
D
A
D
V
N
L
E
V
T
R
D
F
V
E
R
V
-----
R
-----
E
----
E
-----
A
---------
L
G
K
-----
Q
VL
E
S
L
T
-
P
------
A
E
V
--
I
L
A
T
V
Y
E
A
L
K
----
E
A
--
L
---
G
G
---
E
A
-----
R
L
P
VLKD---
R
N
L
W
F
L
V
G
L
Q
G
S
G
K
T
T
T
A
A
K
L
A
L
Y
Y
K
G
K
G
R
-
R
-
P
L
L
V
A
A
D
T
Q
R
P
A
A
R
E
Q
L
R
L
L
G
E
K
V
G
V
P
V
L
--
E
V
M
-
D
--
G
E
--
S
-
P
E
S
I
R
R
R
V
E
E
K
A
R
L
E
A
R
D
L
I
L
V
D
T
A
G
R
L
Q
I
D
E
P
--
L
M
G
E
L
A
R
----
L
K
E
--
V
------
L
------
G
------
P
D
E
V
L
L
V
L
D
A
M
T
G
Q
E
A
L
S
V
A
R
A
F
D
E
K
V
G
-
V
T
G
L
V
L
T
K
L
D
G
D
A
R
G
G
A
A
L
S
A
R
H
V
T
G
K
P
I
Y
F
A
G
V
S
E
K
P
E
G
L
E
P
F
Y
P
E
R
L
A
G
R
I
L
G
M
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
74.64
40%
-80
- C5 -
1RJ9
3
SRP54_THEAQ
B:
[14-295]
-------------
G
R
L
--
R
G
R
------------
G
RI
T
E
E
D
L
K
A
T
L
R
E
I
R
R
A
L
M
D
A
D
V
N
L
E
V
T
R
D
F
V
E
R
V
-----
R
-----
E
----
E
-----
A
---------
L
G
K
-----
Q
VL
E
S
L
T
-
P
------
A
E
V
--
I
L
A
T
V
Y
E
A
L
K
----
E
A
--
L
---
G
G
---
E
A
-----
R
L
P
V
L
K
D---
R
N
L
W
F
L
V
G
L
Q
G
S
G
K
T
T
T
A
A
K
L
A
L
Y
Y
K
G
K
G
R
-
R
-
P
L
L
V
A
A
D
T
Q
R
P
A
A
R
E
Q
L
R
L
L
G
E
K
V
G
V
P
V
L
--
E
V
M
-
D
--
G
E
--
S
-
P
E
S
I
R
R
R
V
E
E
K
A
R
L
E
A
R
D
L
I
L
V
D
T
A
G
R
L
Q
I
D
E
P
--
L
M
G
E
L
A
R
----
L
K
E
--
V
------
L
------
G
------
P
D
E
V
L
L
V
L
D
A
M
T
G
Q
E
A
L
S
V
A
R
A
F
D
E
K
V
G
-
V
T
G
L
V
L
T
K
L
D
G
D
A
R
G
G
A
A
L
S
A
R
H
V
T
G
K
P
I
Y
F
A
G
V
S
E
K
P
E
G
L
E
P
F
Y
P
E
R
L
A
G
R
I
L
G
M
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
123
HHSearch
74.57
34%
-94
- C5 -
1RJ9
3
FTSY_THEAQ
A:
[27-303]
---------------------------------------
N
L
E
E
V
L
E
E
L
E
M
A
L
L
A
A
D
V
G
L
S
A
T
E
E
I
L
Q
E
V
-----
R
-----
A
----
S
-----
G
R
----------------
K
--
D
L
K
E
-
A
------
V
K
E
--
K
L
V
G
M
L
E
P
D
E
R
R
A
T
L
R
K
L
G
---
F
N
---
P
Q
KPKPV
E
P
K
-------
G
R
V
V
L
V
V
G
V
N
G
V
G
K
T
T
T
I
A
K
L
G
R
Y
Y
Q
N
L
G
K
-
K
-
V
M
F
C
A
G
D
T
F
R
A
A
G
G
T
Q
L
S
E
W
G
K
R
L
S
I
P
V
I
--
Q
-
G
-
P
--
E
G
T-
D
-
S
A
A
L
A
Y
D
A
V
Q
A
M
K
A
R
G
Y
D
L
L
F
V
D
T
A
G
R
L
H
T
K
H
N
--
L
M
E
E
L
K
K
V
K
R
A
I
A
K
A
D
P
------
E
------
E
------
P
K
E
V
W
L
V
L
D
A
V
T
G
Q
N
G
L
E
Q
A
K
K
F
H
E
A
V
G
-
L
T
G
V
I
V
T
K
L
D
G
T
A
K
G
G
V
L
I
P
I
V
R
T
L
K
V
P
I
K
F
V
G
V
G
E
G
P
D
D
L
Q
P
F
D
P
E
A
F
V
E
A
L
L
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
PsiBlast_CBE
73.91
34%
-91
- C5 -
3E70
3
?
C:
[49-324]
-------------------------------------
E
K
D
V
D
K
A
L
D
E
L
E
I
D
L
L
E
A
D
V
A
L
E
V
V
D
A
L
R
E
K
I
-----
K
-----
Q
----
K
LVGKK
V
R
I
-----
G
---
G
-----
K
--
I
I
E
E
-
A
------
V
K
E
--
A
V
S
E
I
L
E
T
S
R
----
R
I
--
D
---
L
I
EEI
R
K
-----
A
E
K
-------
P
Y
V
I
M
F
V
G
F
N
G
S
G
K
T
T
T
I
A
K
L
A
N
W
L
K
N
H
G
F
-
S
-
V
V
I
A
A
S
D
T
F
R
A
G
A
I
E
Q
L
E
E
H
A
K
R
I
G
V
K
V
I
K-
H
-
S
-
Y
--
G
A
--
D
-
P
A
A
V
A
Y
D
A
I
Q
H
A
K
A
R
G
I
D
V
V
L
I
D
T
A
G
R
S
E
T
N
R
N
--
L
M
D
E
M
K
K
----
I
A
R
--
V
------
T
------
K
------
P
N
L
V
I
F
V
G
D
A
L
A
G
N
A
I
V
E
Q
A
R
Q
F
N
E
A
V
K
-
I
D
G
I
I
L
T
K
L
D
A
D
A
R
G
G
A
A
L
S
I
S
Y
V
I
D
A
P
I
L
F
V
G
V
G
Q
G
Y
D
D
L
R
P
F
E
K
E
W
F
L
E
R
I
F
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
PsiBlast_CBE
73.13
34%
-93
- C5 -
3DMD
4
?
B:
[49-324]
-------------------------------------
E
K
D
V
D
K
A
L
D
E
L
E
I
D
L
L
E
A
D
V
A
L
E
V
V
D
A
L
R
E
K
I
-----
K
-----
Q
----
K
L
VG
K
K
V
R
I
-----
G
T
D
K
G
-----
K
--
I
I
E
E
-
A
------
V
K
E
--
A
V
S
E
I
L
E
T
S
R
----
R
I
--
D
---
L
I
E
E
I
R
K
-----
A
E
K
-------
P
Y
V
I
M
F
V
G
F
N
G
S
G
K
T
T
T
I
A
K
L
A
N
W
L
K
N
H
G
F
-
S
-
V
V
I
A
A
S
D
T
F
R
A
G
A
I
E
Q
L
E
E
H
A
K
R
I
G
V
K
V
I
K
-
H
-
S
-
Y
--
G
A
--
D
-
P
A
A
V
A
Y
D
A
I
Q
H
A
K
A
R
G
I
D
V
V
L
I
D
T
A
G
R
S
E
T
N
R
N
--
L
M
D
E
M
K
K
----
I
A
R
--
V
------
T
------
K
------
P
N
L
V
I
F
V
G
D
A
L
A
G
N
A
I
V
E
Q
A
R
Q
F
N
E
A
V
K
-
I
D
G
I
I
L
T
K
L
D
A
D
A
R
G
G
A
A
L
S
I
S
Y
V
I
D
A
P
I
L
F
V
G
V
G
Q
G
Y
D
D
L
R
P
F
E
K
E
W
F
L
E
R
I
F
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
118
HHSearch
72.68
34%
-95
- C5 -
2YHS
5
FTSY_ECOLI
A:
[223-495]
---------------------------------------
I
D
D
D
L
F
E
E
L
E
E
Q
L
L
I
A
D
V
G
V
E
T
T
R
K
I
I
T
N
L
-----
T
-----
E
----
G
-----
A
S
R
K
----
Q
L
R
D
A
-----
E
--
A
L
Y
G
-
L
------
L
K
E
--
E
M
G
E
I
L
A
K
------
V
D
E-
P
---
L
N
---
V
E
-----
G
K
A
-------
P
F
V
I
L
M
V
G
V
N
G
V
G
K
T
T
T
I
G
K
L
A
R
Q
F
E
Q
-
Q
G
K
S
-
V
M
L
A
A
G
D
T
F
R
A
A
A
V
E
Q
L
Q
V
W
G
Q
R
N
N
I
P
V
I
--
A
-
Q
-
H
--
T
G
A-
D
-
S
A
S
V
I
F
D
A
I
Q
A
A
K
A
R
N
I
D
V
L
I
A
D
T
A
G
R
L
Q
N
K
S
H
--
L
M
E
E
L
K
K
----
I
V
R
--
V
M
K
K
L
DV
E
------
A
------
P
H
E
V
M
L
T
I
D
A
S
T
G
Q
N
A
V
S
Q
A
K
L
F
H
E
A
V
G
-
L
T
G
I
T
L
T
K
L
D
G
T
A
K
G
G
V
I
F
S
V
A
D
Q
F
G
I
P
I
R
Y
I
G
V
G
E
R
I
E
D
L
R
P
F
K
A
D
D
F
I
E
A
L
F
A
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
PsiBlast_CBE
70.88
41%
-101
- C5 -
1VMA
1
?
B:
[80-304]
------------------------------------------------------------------------------------------------------------------
L
E
-
S
------
L
K
E
--
I
I
L
E
I
L
N
F
------
D
T
--
K
---
L
N
---
V
P
-----
P
E
P
-------
P
F
V
I
M
V
V
G
V
N
G
T
G
K
T
T
S
C
G
K
L
A
K
M
F
V
D
E
G
K
-
S
-
V
V
L
A
A
A
D
T
F
R
A
A
A
I
E
Q
L
K
I
W
G
E
R
V
G
A
T
V
I
S-
H
-
S
-
E
--
G
A
--
D
-
P
A
A
V
A
F
D
A
V
A
H
A
L
A
R
N
K
D
V
V
I
I
D
T
A
G
R
L
H
T
K
K
N
--
L
M
E
E
L
R
K
----
V
H
R
--
V
------
V
------
K
KKIPDA
P
H
E
T
L
L
V
I
D
A
T
T
G
Q
N
G
L
V
Q
A
K
I
F
K
E
A
V
N
-
V
T
G
I
I
L
T
K
L
D
G
T
A
K
G
G
I
T
L
A
I
A
R
E
L
G
I
P
I
K
F
I
G
V
G
E
K
A
E
D
L
R
P
F
D
P
E
A
F
V
E
V
L
L
S
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
67.86
37%
-103
- C5 -
2YHS
5
FTSY_ECOLI
A:
[255-495]
----------------------------------------------------------------------------------------------------
G
A
S
R
-----
K
--
Q
L
R
D
-
A
EAL
Y
G
L
L
K
E
--
E
M
G
E
I
L
-
A
K
V
----
D
E
--
P
---
L
N
---
V
E
-----
G
K
A
-------
P
F
V
I
L
M
V
G
V
N
G
V
G
K
T
T
T
I
G
K
L
A
R
Q
F
E
Q
Q
G
K
-
S
-
V
M
L
A
A
G
D
T
F
R
A
A
A
V
E
Q
L
Q
V
W
G
Q
R
N
N
I
P
V
I
--
A
-
Q
-
H
--
T
G
--
A
D
S
A
S
V
I
F
D
A
I
Q
A
A
K
A
R
N
I
D
V
L
I
A
D
T
A
G
R
L
Q
N
K
S
H
--
L
M
E
E
L
K
K
----
I
V
R
--
V
------
M
------
K
K
L
DVEA
P
H
E
V
M
L
T
I
D
A
S
T
G
Q
N
A
V
S
Q
A
K
L
F
H
E
A
V
G
-
L
T
G
I
T
L
T
K
L
D
G
T
A
K
G
G
V
I
F
S
V
A
D
Q
F
G
I
P
I
R
Y
I
G
V
G
E
R
I
E
D
L
R
P
F
K
A
D
D
F
I
E
A
L
F
A
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
PsiBlast_CBE
67.59
38%
-94
- C5 -
4C7O
5
FTSY_ECOLI
D:
[36-264]
----------------------------------------------------------------------------------------------------
G
A
S
R
-----
K
--
Q
L
R
D
-
A
E
A
L
Y
G
L
L
K
E
--
E
M
G
E
I
L
-
A
K
V
----
D
E
--
P
---
L
N
---
V
E
-----
G
K
A
-------
P
F
V
I
L
M
V
G
V
N
G
V
G
K
T
T
T
I
G
K
L
A
R
Q
F
E
Q
Q
G
K
-
S
-
V
M
L
A
A
G
D
T
F
R
A
A
A
V
E
Q
L
Q
V
W
G
Q
R
N
N
I
P
V
I
--
A
-
Q
-
H
--
T
G
--
A
D
S
A
S
V
I
F
D
A
I
Q
A
A
K
A
R
N
I
D
V
L
I
A
D
T
A
G
R
L
Q
N
K
S
H
--
L
M
E
E
L
K
K
----
I
V
R
--
V
------
M
------
K
K
L
DVEA
P
H
E
V
M
L
T
I
D
A
S
T
G
Q
N
A
V
S
Q
A
K
L
F
H
E
A
V
G
-
L
T
G
I
T
L
T
K
L
D
G
T
A
K
G
G
V
I
F
S
V
A
D
Q
F
G
I
P
I
R
Y
I
G
V
G
E
R
I
E
D
L
R
P
F
K
A
D
D
F
I
E
A
L
F
A
R
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
67.34
38%
-87
- C5 -
4C7O
4
FTSY_ECOLI
B:
[36-264]
----------------------------------------------------------------------------------------------------
G
A
S
R
-----
K
--
Q
L
R
D
-
A
E
A
L
Y
G
L
L
K
E
--
E
M
G
E
I
L
-
A
K
V
----
D
E
--
P
---
L
N
---
V
E
-----
G
K
A
-------
P
F
V
I
L
M
V
G
V
N
G
V
G
K
T
T
T
I
G
K
L
A
R
Q
F
E
Q
Q
G
K
-
S
-
V
M
L
A
A
G
D
T
F
R
A
A
A
V
E
Q
L
Q
V
W
G
Q
R
N
N
I
P
V
I
--
A
-
Q
-
H
--
T
G
--
A
D
S
A
S
V
I
F
D
A
I
Q
A
A
K
A
R
N
I
D
V
L
I
A
D
T
A
G
R
L
Q
N
K
S
H
--
L
M
E
E
L
K
K
----
I
V
R
--
V
------
M
------
K
K
L
DVEA
P
H
E
V
M
L
T
I
D
A
S
T
G
Q
N
A
V
S
Q
A
K
L
F
H
E
A
V
G
-
L
T
G
I
T
L
T
K
L
D
G
T
A
K
G
G
V
I
F
S
V
A
D
Q
F
G
I
P
I
R
Y
I
G
V
G
E
R
I
E
D
L
R
P
F
K
A
D
D
F
I
E
A
L
F
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
PsiBlast_CBE
64.54
38%
-88
- C5 -
2J7P
9
FTSY_THEAQ
E:
[94-281]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
T
T
T
I
A
K
L
G
R
Y
Y
Q
N
L
G
K
-
K
-
V
M
F
C
A
G
D
T
F
R
A
A
G
G
T
Q
L
S
E
W
G
K
R
L
S
I
P
V
I
--
Q
G
P
-
E
--
G
T
--
D
-
P
A
A
L
A
Y
D
A
V
Q
A
M
K
A
R
G
Y
D
L
L
F
V
D
T
A
G
R
L
H
T
K
H
N
--
L
M
E
E
L
K
K
----
V
K
R
--
A
------
I
AKADPE
E
------
P
K
E
V
W
L
V
L
D
A
V
T
G
Q
N
G
L
E
Q
A
K
K
F
H
E
A
V
G
-
L
T
G
V
I
V
T
K
L
D
G
T
A
K
G
G
V
L
I
P
I
V
R
T
L
K
V
P
I
K
F
V
G
V
G
E
G
P
D
D
L
Q
P
F
D
P
E
A
F
V
E
A
L
L
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
63
PsiBlast_CBE
64.23
38%
-89
- C5 -
2J7P
5
FTSY_THEAQ
D:
[94-281]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
T
T
T
I
A
K
L
G
R
Y
Y
Q
N
L
G
K
-
K
-
V
M
F
C
A
G
D
T
F
R
A
A
G
G
T
Q
L
S
E
W
G
K
R
L
S
I
P
V
I
--
Q
G
P
-
E
--
G
T
--
D
-
P
A
A
L
A
Y
D
A
V
Q
A
M
K
A
R
G
Y
D
L
L
F
V
D
T
A
G
R
L
H
T
K
H
N
--
L
M
E
E
L
K
K
----
V
K
R
--
A
------
I
A
K
A
DPE
E
------
P
K
E
V
W
L
V
L
D
A
V
T
G
Q
N
G
L
E
Q
A
K
K
F
H
E
A
V
G
-
L
T
G
V
I
V
T
K
L
D
G
T
A
K
G
G
V
L
I
P
I
V
R
T
L
K
V
P
I
K
F
V
G
V
G
E
G
P
D
D
L
Q
P
F
D
P
E
A
F
V
E
A
L
L
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
PsiBlast_CBE
63.69
38%
-89
- C5 -
1OKK
8
FTSY_THEAQ
D:
[114-301]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
T
T
T
I
A
K
L
G
R
Y
Y
Q
N
L
G
K
-
K
-
V
M
F
C
A
G
D
T
F
R
A
A
G
G
T
Q
L
S
E
W
G
K
R
L
S
I
P
V
I
--
Q
G
P
-
E
--
G
T
--
D
-
P
A
A
L
A
Y
D
A
V
Q
A
M
K
A
R
G
Y
D
L
L
F
V
D
T
A
G
R
L
H
T
K
H
N
--
L
M
E
E
L
K
K
----
V
K
R
--
A
------
I
AKADPE
E
------
P
K
E
V
W
L
V
L
D
A
V
T
G
Q
N
G
L
E
Q
A
K
K
F
H
E
A
V
G
-
L
T
G
V
I
V
T
K
L
D
G
T
A
K
G
G
V
L
I
P
I
V
R
T
L
K
V
P
I
K
F
V
G
V
G
E
G
P
D
D
L
Q
P
F
D
P
E
A
F
V
E
A
L
L
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
PsiBlast_CBE
63.67
38%
-104
- C5 -
2IYL
3
FTSY_THEAQ
D:
[95-282]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
T
T
T
I
A
K
L
G
R
Y
Y
Q
N
L
G
K
-
K
-
V
M
F
C
A
G
D
T
------
T
Q
L
S
E
W
G
K
R
L
S
I
P
V
I
--
Q
G
P
-
E
--
G
T
--
D
-
P
A
A
L
A
Y
D
A
V
Q
A
M
K
A
R
G
Y
D
L
L
F
V
D
T
A
G
R
L
H
T
K
H
N
--
L
M
E
E
L
K
K
----
V
K
R
--
A
------
I
AKADPE
E
------
P
K
E
V
W
L
V
L
D
A
V
T
G
Q
--
L
E
Q
A
K
K
F
H
E
A
V
G
-
L
T
G
V
I
V
T
K
L
D
G
T
A
K
G
G
V
L
I
P
I
V
R
T
L
K
V
P
I
K
F
V
G
V
G
E
G
P
D
D
L
Q
P
F
D
P
E
A
F
V
E
A
L
L
E
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
PsiBlast_CBE
61.60
38%
-88
- C5 -
1RJ9
3
FTSY_THEAQ
A:
[115-302]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
T
T
T
I
A
K
L
G
R
Y
Y
Q
N
L
G
K
-
K
-
V
M
F
C
A
G
D
T
F
R
A
A
G
G
T
Q
L
S
E
W
G
K
R
L
S
I
P
V
I
--
Q
G
P
-
E
--
G
T
--
D
-
S
A
A
L
A
Y
D
A
V
Q
A
M
K
A
R
G
Y
D
L
L
F
V
D
T
A
G
R
L
H
T
K
H
N
--
L
M
E
E
L
K
K
----
V
K
R
--
A
------
I
A
K
A
DPE
E
------
P
K
E
V
W
L
V
L
D
A
V
T
G
Q
N
G
L
E
Q
A
K
K
F
H
E
A
V
G
-
L
T
G
V
I
V
T
K
L
D
G
T
A
K
G
G
V
L
I
P
I
V
R
T
L
K
V
P
I
K
F
V
G
V
G
E
G
P
D
D
L
Q
P
F
D
P
E
A
F
V
E
A
L
L
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
PsiBlast_CBE
60.06
38%
-91
- C5 -
2Q9B
11
FTSY_THEAQ
A:
[115-302]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
T
T
T
I
A
K
L
G
R
Y
Y
Q
N
L
G
K
-
K
-
V
M
F
C
A
G
D
T
F
R
A
A
G
G
T
Q
L
S
E
W
G
K
R
L
S
I
P
V
I
--
Q
G
P
-
E
--
G
T
--
D
-
P
A
A
L
A
Y
D
A
V
Q
A
M
K
A
R
G
Y
D
L
L
F
V
D
T
A
G
R
L
H
T
K
H
N
--
L
M
E
E
L
K
K
----
V
K
R
--
A
------
I
A
K
A
DPE
E
------
P
K
E
V
W
L
V
L
D
A
V
T
G
Q
N
G
L
E
Q
A
K
K
F
H
E
A
V
G
-
L
T
G
V
I
V
T
K
L
D
G
T
A
K
G
G
V
L
I
P
I
V
R
T
L
K
V
P
I
K
F
V
G
V
G
E
G
P
D
D
L
Q
P
F
D
P
E
A
F
V
E
A
L
L
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
PsiBlast_CBE
59.83
38%
-88
- C5 -
2Q9C
7
FTSY_THEAQ
A:
[115-302]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
T
T
T
I
A
K
L
G
R
Y
Y
Q
N
L
G
K
-
K
-
V
M
F
C
A
G
D
T
F
R
A
A
G
G
T
Q
L
S
E
W
G
K
R
L
S
I
P
V
I
--
Q
G
P
-
E
--
G
T
--
D
-
P
A
A
L
A
Y
D
A
V
Q
A
M
K
A
R
G
Y
D
L
L
F
V
D
T
A
G
R
L
H
T
K
H
N
--
L
M
E
E
L
K
K
----
V
K
R
--
A
------
I
A
K
A
DPE
E
------
P
K
E
V
W
L
V
L
D
A
V
T
G
Q
N
G
L
E
Q
A
K
K
F
H
E
A
V
G
-
L
T
G
V
I
V
T
K
L
D
G
T
A
K
G
G
V
L
I
P
I
V
R
T
L
K
V
P
I
K
F
V
G
V
G
E
G
P
D
D
L
Q
P
F
D
P
E
A
F
V
E
A
L
L
E
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------