@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_1093: (2015-12-20 )
MLTQLKTYPKLLKHYEEIKEVHMRDWFSKDKERASRYFVQLESLSLDYSKNRLNDTTLKLLFELAKDCSLKEKIEAMFKGEKINTTEKRAVLHTALRSLNDAEILLDNMEVLKSVRSVLKRMRAFSDSVRSGKRLGYTNQVITDIVNIGIGGSDLGALMVCTALKRYGHPRLKMHFVSNVDGTQILDVLEKINPASTLFIVASKTFSTQETLTNALTARKWFVERSGDEKHIAKHFVAVSTNKEAVQQFGIDEHNMFEFWDFVGGRYSLWSAIGLSIMIYLGKKNFNALLKGAYLMDEHFRNAPFESNLPVLMGLIGVWYINFFQSKSHLIAPYDQYLRHFPKFIQQLDMESNGKRISKKGEIIPYDTCPVVWGDMGINAQHAFFQLLHQGTHLIPIDFIASLDKKPNAKGHHEILFSNVLAQAQAFMKGKSYEEALGELLSKGLDKDEAKDLAHHRVFFGNRPSNILLLEKISPSNIGALVALYEHKVFVQGVIWDINSFDQWGVELGKELAVPILQELEGHKSNAYFDSSTRHLIELYKNYNQ
Atome Classification :
(47 SA)
-----------------------------------------......-------...10..-..-....-20.----....----...30........40------.-------.------..-------....50........60........70........80........90........100.-..-....110.......120.......130.......140.......150.......160..---....-----.170.-----....-..180.......190.......200.......210.......220--...----.-..-----.-----.230........240.......250.......260.......270..-.-....280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400-----.....-...------410-........420.......430.......440.-.-.....450.......460.......470.......480.......490.......500.......510.---......-520---...--------.-..--.530.......540...--
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-----------------------------------------MLTQ
L
K
-------
T
Y
P
K
L
L
K
-
H
Y
-
E
E
I
K
-
E
V
H
----
M
R
D
W
----
F
S
K
D
K
E
R
A
S
R
Y
F
V
Q
L
------
E
-------
S
------
L
S-------LDYSKNRLN
D
T
T
L
K
L
L
F
E
L
A
K
DC
S
L
K
E
K
I
E
A
M
FKGEKIN
T
T
E
K
R
A
V
L
H
T
A
L
R
SLN
D
A
E
-
I
L
-
L
D
N
M
E
V
L
K
S
V
R
S
V
L
K
R
M
R
A
F
S
D
S
V
RSGKRLGY
T
N
Q
V
I
T
D
I
V
NIGIG
G
S
D
L
G
A
L
M
V
C
T
A
L
---
K
RYG-----HP
R
L
K
-----
M
H
F
V-SNVD
G
T
Q
I
L
D
V
L
E
KINPA
S
T
L
F
I
V
ASKTF
S
T
Q
E
T
L
T
N
A
L
T
A
R
K
W
---
F
V
E----R-SG-----
D
-----
E
K
-
H
I
A
K
H
F
V
A
VST
N
K
E
A
V
Q
Q
FGIDE
H
N
M
F
E
F
W
D
F
VGG
R
Y
S
L
W
S
A
I
G
-
L
-
S
I
M
I
Y
LGKK
N
F
N
A
L
L
K
G
A
Y
L
M
D
E
H
FRNAPFESN
L
P
V
L
M
G
L
I
G
V
W
Y
I
N
F
F
QSKSHLIA
P
Y
D
Q
Y
L
R
H
F
P
K
F
I
Q
Q
LDMESNGKRISKKG
E
I
I
PYDTCP
V
V
WGDMGIN
A
Q
H
A
F
F
Q
L
L
HQGT
H
L
I
P
I
D
F
I
A
------SLDKK-PNA------KG--
H
H
E
I
L
F
S
N
V
L
A
Q
A
Q
A
F
MKGK
S
Y
E
E
A
L
G
E
L
L
S
K-G-L
D
K
D
E
A
K
D
L
A
HH
R
V
F
FGNRPS
N
I
L
L
L
E
KISPSN
I
G
A
L
V
A
L
Y
EH
K
V
F
V
Q
G
V
I
WDIN
S
F
D
Q
W
G
V
E
L
G
K
E
L
A
---
V
P
I
L
Q
E
-
L
EG---HKS--------N-AY--FDS
S
T
R
H
L
I
E
L
Y
K
NYNQ--
13
PsiBlast_PDB
97.29
51%
-105
- C5 -
1IAT
3
G6PI_HUMAN
A:
[3-549]
------------------------------------------
L
T
R
D
P
-------
Q
F
Q
K
L
Q
Q
-
W
Y
-
R
E
H
R
S
E
L
N
----
L
R
R
L
----
F
D
A
N
K
D
R
F
N
H
F
S
L
T
L
------
N
-------
T
NH
G
H
--
I
L
-------
V
D
Y
S
K
N
L
V
T
E
D
V
M
R
M
L
V
D
L
A
K
S
R
G
V
E
A
A
R
E
R
M
F
N
G
E
K
I
N
Y
T
E
G
R
A
V
L
H
V
A
L
R
N
R
S
N
T
P
-
I
L
-
V
D
G
K
D
V
M
P
E
V
N
K
V
L
D
K
M
K
S
F
C
Q
R
V
R
S
G
D
W
K
G
Y
T
G
K
T
I
T
D
V
I
N
I
G
I
G
G
S
D
L
G
P
L
M
V
T
E
A
L
---
K
P
Y
S
-----
S
G
G
P
R
-----
V
W
Y
V
-
S
N
I
D
G
T
H
I
A
K
T
L
A
Q
L
N
P
E
S
S
L
F
I
I
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
E
T
A
K
E
W
---
F
L
Q
----
A
-
A
K
-----
D
-----
P
S
-
A
V
A
K
H
F
V
A
L
S
T
N
T
T
K
V
K
E
F
G
I
D
P
Q
N
M
F
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
-
L
-
S
I
A
L
H
V
G
F
D
N
F
E
Q
L
L
S
G
A
H
W
M
D
Q
H
F
R
T
T
P
L
E
K
N
A
P
V
L
L
A
L
L
G
I
W
Y
I
N
C
F
G
C
E
T
H
A
M
L
P
Y
D
Q
Y
L
H
R
F
A
A
Y
F
Q
Q
G
D
M
E
S
N
G
K
Y
I
T
K
S
G
T
R
V
D
H
Q
T
G
P
I
V
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
M
I
P
C
D
F
L
I
------
P
V
Q
T
Q
H
P
I
R
------
K
G
L
-
H
H
K
I
L
L
A
N
F
L
A
Q
T
E
A
L
M
R
G
K
S
T
E
E
A
R
K
E
L
Q
A
A
-
G
-
K
S
P
E
D
L
E
R
L
L
P
H
K
V
F
E
G
N
R
P
T
N
S
I
V
F
T
K
L
T
P
F
M
L
G
A
L
V
A
M
Y
E
H
K
I
F
V
Q
G
I
I
W
D
I
N
S
F
D
Q
W
G
V
E
L
G
K
Q
L
A
---
K
K
I
E
P
E
-
L
D
G
---
S
A
Q
--------
V
-
T
S
--
H
D
A
S
T
N
G
L
I
N
F
I
K
Q
Q
R
E
--
41
PsiBlast_CBE
97.06
50%
-106
- C5 -
2CXQ
5
G6PI_MOUSE
B:
[4-550]
------------------------------------------
L
T
R
N
P
-------
Q
F
Q
K
L
L
E
W
H
R
-
A
N
S
A
-
N
L
K
----
L
R
E
L
----
F
E
A
D
P
E
R
F
N
N
F
S
L
N
L
------
N
-------
T
NHGH--
I
L
-------
V
D
Y
S
K
N
L
V
S
K
E
V
M
Q
M
L
V
E
L
A
K
S
R
G
V
E
A
A
R
D
N
M
F
S
G
S
K
I
N
Y
T
E
D
R
A
V
L
H
V
A
L
R
N
R
S
N
T
P
-
I
K
-
V
D
G
K
D
V
M
P
E
V
N
R
V
L
D
K
M
K
S
F
C
Q
R
V
R
S
G
D
W
K
G
Y
T
G
K
S
I
T
D
I
I
N
I
G
I
G
G
S
D
L
G
P
L
M
V
T
E
A
L
---
K
P
Y
S
-----
K
G
G
P
R
-----
V
W
F
V
-
S
N
I
D
G
T
H
I
A
K
T
L
A
S
L
S
P
E
T
S
L
F
I
I
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
E
T
A
K
E
W
---
F
L
E
----
A
-
A
K
-----
D
-----
P
S
-
A
V
A
K
H
F
V
A
L
S
T
N
T
A
K
V
K
E
F
G
I
D
P
Q
N
M
F
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
-
L
-
S
I
A
L
H
V
G
F
D
H
F
E
Q
L
L
S
G
A
H
W
M
D
Q
H
F
L
K
T
P
L
E
K
N
A
P
V
L
L
A
L
L
G
I
W
Y
I
N
C
Y
G
C
E
T
H
A
L
L
P
Y
D
Q
Y
M
H
R
F
A
A
Y
F
Q
Q
G
D
M
E
S
N
G
K
Y
I
T
K
S
G
A
R
V
D
H
Q
T
G
P
I
V
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
M
I
P
C
D
F
L
I
------
P
V
Q
T
Q
H
P
I
R
------
K
G
L-
H
H
K
I
L
L
A
N
F
L
A
Q
T
E
A
L
M
K
G
K
L
P
E
E
A
R
K
E
L
Q
A
A
-
G
-
K
S
P
E
D
L
E
K
L
L
P
H
K
V
F
E
G
N
R
P
T
N
S
I
V
F
T
K
L
T
P
F
I
L
G
A
L
I
A
M
Y
E
H
K
I
F
V
Q
G
I
M
W
D
I
N
S
F
D
Q
W
G
V
E
L
G
K
Q
L
A
---
K
K
I
E
P
E
-
L
E
G
---
S
S
A
--------
V
-
T
S
--
H
D
S
S
T
N
G
L
I
S
F
I
K
Q
Q
R
D
--
44
PsiBlast_CBE
97.00
50%
-106
- C5 -
2CXO
5
G6PI_MOUSE
B:
[4-550]
------------------------------------------
L
T
R
N
P
-------
Q
F
Q
K
L
L
E
W
H
R
-
A
N
S
A
-
N
L
K
----
L
R
E
L
----
F
E
A
D
P
E
R
F
N
N
F
S
L
N
L
------
N
-------
T
NHGH--
I
L
-------
V
D
Y
S
K
N
L
V
S
K
E
V
M
Q
M
L
V
E
L
A
K
S
R
G
V
E
A
A
R
D
N
M
F
S
G
S
K
I
N
Y
T
E
D
R
A
V
L
H
V
A
L
R
N
R
S
N
T
P
-
I
K
-
V
D
G
K
D
V
M
P
E
V
N
R
V
L
D
K
M
K
S
F
C
Q
R
V
R
S
G
D
W
K
G
Y
T
G
K
S
I
T
D
I
I
N
I
G
I
G
G
S
D
L
G
P
L
M
V
T
E
A
L
---
K
P
Y
S
-----
K
G
G
P
R
-----
V
W
F
V
-
S
N
I
D
G
T
H
I
A
K
T
L
A
S
L
S
P
E
T
S
L
F
I
I
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
E
T
A
K
E
W
---
F
L
E
----
A
-
A
K
-----
D
-----
P
S
-
A
V
A
K
H
F
V
A
L
S
T
N
T
A
K
V
K
E
F
G
I
D
P
Q
N
M
F
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
-
L
-
S
I
A
L
H
V
G
F
D
H
F
E
Q
L
L
S
G
A
H
W
M
D
Q
H
F
L
K
T
P
L
E
K
N
A
P
V
L
L
A
L
L
G
I
W
Y
I
N
C
Y
G
C
E
T
H
A
L
L
P
Y
D
Q
Y
M
H
R
F
A
A
Y
F
Q
Q
G
D
M
E
S
N
G
K
Y
I
T
K
S
G
A
R
V
D
H
Q
T
G
P
I
V
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
M
I
P
C
D
F
L
I
------
P
V
Q
T
Q
H
P
I
R
------
K
G
L-
H
H
K
I
L
L
A
N
F
L
A
Q
T
E
A
L
M
K
G
K
L
P
E
E
A
R
K
E
L
Q
A
A
-
G
-
K
S
P
E
D
L
E
K
L
L
P
H
K
V
F
E
G
N
R
P
T
N
S
I
V
F
T
K
L
T
P
F
I
L
G
A
L
I
A
M
Y
E
H
K
I
F
V
Q
G
I
M
W
D
I
N
S
F
D
Q
W
G
V
E
L
G
K
Q
L
A
---
K
K
I
E
P
E
-
L
E
G
---
S
S
A
--------
V
-
T
S
--
H
D
S
S
T
N
G
L
I
S
F
I
K
Q
Q
R
D
--
12
PsiBlast_PDB
96.96
51%
-104
- C5 -
1JLH
-
G6PI_HUMAN
A:
[3-549]
------------------------------------------
L
T
R
D
P
-------
Q
F
Q
K
L
Q
Q
-
W
Y
-
R
E
H
R
S
E
L
N
----
L
R
R
L
----
F
D
A
N
K
D
R
F
N
H
F
S
L
T
L
------
N
-------
T
NH
G
H
--
I
L
-------
V
D
Y
S
K
N
L
V
T
E
D
V
M
R
M
L
V
D
L
A
K
S
R
G
V
E
A
A
R
E
R
M
F
N
G
E
K
I
N
Y
T
E
G
R
A
V
L
H
V
A
L
R
N
R
S
N
T
P
-
I
L
-
V
D
G
K
D
V
M
P
E
V
N
K
V
L
D
K
M
K
S
F
C
Q
R
V
R
S
G
D
W
K
G
Y
T
G
K
T
I
T
D
V
I
N
I
G
I
G
G
S
D
L
G
P
L
M
V
T
E
A
L
---
K
P
Y
S
-----
S
G
G
P
R
-----
V
W
Y
V
-
S
N
I
D
G
T
H
I
A
K
T
L
A
Q
L
N
P
E
S
S
L
F
I
I
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
E
T
A
K
E
W
---
F
L
Q
----
A
-
A
K
-----
D
-----
P
S
-
A
V
A
K
H
F
V
A
L
S
T
N
T
T
K
V
K
E
F
G
I
D
P
Q
N
M
F
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
-
L
-
S
I
A
L
H
V
G
F
D
N
F
E
Q
L
L
S
G
A
H
W
M
D
Q
H
F
R
T
T
P
L
E
K
N
A
P
V
L
L
A
L
L
G
I
W
Y
I
N
C
F
G
C
E
T
H
A
M
L
P
Y
D
Q
Y
L
H
R
F
A
A
Y
F
Q
Q
G
D
M
E
S
N
G
K
Y
I
T
K
S
G
T
R
V
D
H
Q
T
G
P
I
V
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
E
M
I
P
C
D
F
L
I
------
P
V
Q
T
Q
H
P
I
R
------
K
G
L
-
H
H
K
I
L
L
A
N
F
L
A
Q
T
E
A
L
M
R
G
K
S
T
E
E
A
R
K
E
L
Q
A
A
-
G
-
K
S
P
E
D
L
E
R
L
L
P
H
K
V
F
E
G
N
R
P
T
N
S
I
V
F
T
K
L
T
P
F
M
L
G
A
L
V
A
M
Y
E
H
K
I
F
V
Q
G
I
I
W
D
I
N
S
F
D
Q
W
G
V
E
L
G
K
Q
L
A
---
K
K
I
E
P
E
-
L
D
G
---
S
A
Q
--------
V
-
T
S
--
H
D
A
S
T
N
G
L
I
N
F
I
K
Q
Q
R
E
--
49
PsiBlast_CBE
96.83
50%
-106
- C5 -
1U0F
12
G6PI_MOUSE
B:
[4-550]
------------------------------------------
L
T
R
N
P
-------
Q
F
Q
K
L
L
E
W
H
R
-
A
N
S
A
-
N
L
K
----
L
R
E
L
----
F
E
A
D
P
E
R
F
N
N
F
S
L
N
L
------
N
-------
T
NHGH--
I
L
-------
V
D
Y
S
K
N
L
V
N
K
E
V
M
Q
M
L
V
E
L
A
K
S
R
G
V
E
A
A
R
D
N
M
F
S
G
S
K
I
N
Y
T
E
D
R
A
V
L
H
V
A
L
R
N
R
S
N
T
P
-
I
K
-
V
D
G
K
D
V
M
P
E
V
N
R
V
L
D
K
M
K
S
F
C
Q
R
V
R
S
G
D
W
K
G
Y
T
G
K
S
I
T
D
I
I
N
I
G
I
G
G
S
D
L
G
P
L
M
V
T
E
A
L
---
K
P
Y
S
-----
K
G
G
P
R
-----
V
W
F
V
-
S
N
I
D
G
T
H
I
A
K
T
L
A
S
L
S
P
E
T
S
L
F
I
I
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
E
T
A
K
E
W
---
F
L
E
----
A
-
A
K
-----
D
-----
P
S
-
A
V
A
K
H
F
V
A
L
S
T
N
T
A
K
V
K
E
F
G
I
D
P
Q
N
M
L
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
-
L
-
S
I
A
L
H
V
G
F
D
H
F
E
Q
L
L
S
G
A
H
W
M
D
Q
H
F
L
K
T
P
L
E
K
N
A
P
V
L
L
A
L
L
G
I
W
Y
I
N
C
Y
G
C
E
T
H
A
L
L
P
Y
D
Q
Y
M
H
R
F
A
A
Y
F
Q
Q
G
D
M
E
S
N
G
K
Y
I
T
K
S
G
A
R
V
D
H
Q
T
G
P
I
V
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
M
I
P
C
D
F
L
I
------
P
V
Q
T
Q
H
P
I
R
------
K
G
L-
H
H
K
I
L
L
A
N
F
L
A
Q
T
E
A
L
M
K
G
K
L
P
E
E
A
R
K
E
L
Q
A
A
-
G
-
K
S
P
E
D
L
E
K
L
L
P
H
K
V
F
E
G
N
R
P
T
N
S
I
V
F
T
K
L
T
P
F
I
L
G
A
L
I
A
M
Y
E
H
K
I
F
V
Q
G
I
M
W
D
I
N
S
F
D
Q
W
G
V
E
L
G
K
Q
L
A
---
K
K
I
E
P
E
-
L
E
G
---
S
S
A
--------
V
-
T
S
--
H
D
S
S
T
N
G
L
I
S
F
I
K
Q
Q
R
D
--
8
PsiBlast_PDB
96.77
52%
-105
- C5 -
1HM5
-
G6PI_RABIT
A:
[3-549]
------------------------------------------
L
T
R
N
P
-------
Q
F
Q
K
L
Q
Q
W
H
R
-
E
H
G
S
-
E
L
N
----
L
R
H
L
----
F
D
T
D
K
E
R
F
N
H
F
S
L
T
L
------
N
-------
T
NH
G
H
--
I
L
-------
L
D
Y
S
K
N
L
V
T
E
E
V
M
H
M
L
L
D
L
A
K
S
R
G
V
E
A
A
R
E
S
M
F
N
G
E
K
I
N
S
T
E
D
R
A
V
L
H
V
A
L
R
N
R
S
N
T
P
-
I
V
-
V
D
G
K
D
V
M
P
E
V
N
K
V
L
D
K
M
K
A
F
C
Q
R
V
R
S
G
D
W
K
G
Y
T
G
K
T
I
T
D
V
I
N
I
G
I
G
G
S
D
L
G
P
L
M
V
T
E
A
L
---
K
P
Y
S
-----
S
G
G
P
R
-----
V
W
F
V
-
S
N
I
D
G
T
H
I
A
K
T
L
A
C
L
N
P
E
S
S
L
F
I
I
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
K
T
A
K
D
W
---
F
L
L
----
S
-
A
K
-----
D
-----
P
S
-
T
V
A
K
H
F
V
A
L
S
T
N
T
A
K
V
K
E
F
G
I
D
P
Q
N
M
F
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
-
L
-
S
I
A
L
H
V
G
F
D
N
F
E
Q
L
L
S
G
A
H
W
M
D
Q
H
F
R
T
T
P
L
E
K
N
A
P
V
L
L
A
M
L
G
I
W
Y
I
N
C
F
G
C
E
T
Q
A
V
L
P
Y
D
Q
Y
L
H
R
F
A
A
Y
F
Q
Q
G
D
M
E
S
N
G
K
Y
I
T
K
S
G
A
R
V
D
H
Q
T
G
P
I
V
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
M
I
P
C
D
F
L
I
------
P
V
Q
T
Q
H
P
I
R
------
K
G
L
-
H
H
K
I
L
L
A
N
F
L
A
Q
T
E
A
L
M
K
G
K
S
T
E
E
A
R
K
E
L
Q
A
A
-
G
-
K
S
P
E
D
L
M
K
L
L
P
H
K
V
F
E
G
N
R
P
T
N
S
I
V
F
T
K
L
T
P
F
I
L
G
A
L
I
A
M
Y
E
H
K
I
F
V
Q
G
V
V
W
D
I
N
S
F
D
Q
W
G
V
E
L
G
K
Q
L
A
---
K
K
I
E
P
E
-
L
D
G
---
S
S
P
--------
V
-
T
S
--
H
D
S
S
T
N
G
L
I
N
F
I
K
Q
Q
R
E
--
43
PsiBlast_CBE
96.68
50%
-105
- C5 -
2CXP
5
G6PI_MOUSE
B:
[4-550]
------------------------------------------
L
T
R
N
P
-------
Q
F
Q
K
L
L
E
W
H
R
-
A
N
S
A
-
N
L
K
----
L
R
E
L
----
F
E
A
D
P
E
R
F
N
N
F
S
L
N
L
------
N
-------
T
NHGH--
I
L
-------
V
D
Y
S
K
N
L
V
S
K
E
V
M
Q
M
L
V
E
L
A
K
S
R
G
V
E
A
A
R
D
N
M
F
S
G
S
K
I
N
Y
T
E
D
R
A
V
L
H
V
A
L
R
N
R
S
N
T
P
-
I
K
-
V
D
G
K
D
V
M
P
E
V
N
R
V
L
D
K
M
K
S
F
C
Q
R
V
R
S
G
D
W
K
G
Y
T
G
K
S
I
T
D
I
I
N
I
G
I
G
G
S
D
L
G
P
L
M
V
T
E
A
L
---
K
P
Y
S
-----
K
G
G
P
R
-----
V
W
F
V
-
S
N
I
D
G
T
H
I
A
K
T
L
A
S
L
S
P
E
T
S
L
F
I
I
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
E
T
A
K
E
W
---
F
L
E
----
A
-
A
K
-----
D
-----
P
S
-
A
V
A
K
H
F
V
A
L
S
T
N
T
A
K
V
K
E
F
G
I
D
P
Q
N
M
F
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
-
L
-
S
I
A
L
H
V
G
F
D
H
F
E
Q
L
L
S
G
A
H
W
M
D
Q
H
F
L
K
T
P
L
E
K
N
A
P
V
L
L
A
L
L
G
I
W
Y
I
N
C
Y
G
C
E
T
H
A
L
L
P
Y
D
Q
Y
M
H
R
F
A
A
Y
F
Q
Q
G
D
M
E
S
N
G
K
Y
I
T
K
S
G
A
R
V
D
H
Q
T
G
P
I
V
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
M
I
P
C
D
F
L
I
------
P
V
Q
T
Q
H
P
I
R
------
K
G
L-
H
H
K
I
L
L
A
N
F
L
A
Q
T
E
A
L
M
K
G
K
L
P
E
E
A
R
K
E
L
Q
A
A
-
G
-
K
S
P
E
D
L
E
K
L
L
P
H
K
V
F
E
G
N
R
P
T
N
S
I
V
F
T
K
L
T
P
F
I
L
G
A
L
I
A
M
Y
E
H
K
I
F
V
Q
G
I
M
W
D
I
N
S
F
D
Q
W
G
V
E
L
G
K
Q
L
A
---
K
K
I
E
P
E
-
L
E
G
---
S
S
A
--------
V
-
T
S
--
H
D
S
S
T
N
G
L
I
S
F
I
K
Q
Q
R
D
--
38
PsiBlast_CBE
96.57
50%
-105
- C5 -
2CXS
5
G6PI_MOUSE
A:
[4-550]
------------------------------------------
L
T
R
N
P
-------
Q
F
Q
K
L
L
E
W
H
R
-
A
N
S
A
-
N
L
K
----
L
R
E
L
----
F
E
A
D
P
E
R
F
N
N
F
S
L
N
L
------
N
-------
T
NH
G
H
--
I
L
-------
V
D
Y
S
K
N
L
V
S
K
E
V
M
Q
M
L
V
E
L
A
K
S
R
G
V
E
A
A
R
D
N
M
F
S
G
S
K
I
N
Y
T
E
D
R
A
V
L
H
V
A
L
R
N
R
S
N
T
P
-
I
K
-
V
D
G
K
D
V
M
P
E
V
N
R
V
L
D
K
M
K
S
F
C
Q
R
V
R
S
G
D
W
K
G
Y
T
G
K
S
I
T
D
I
I
N
I
G
I
G
G
S
D
L
G
P
L
M
V
T
E
A
L
---
K
P
Y
S
-----
K
G
G
P
R
-----
V
W
F
V
-
S
N
I
D
G
T
H
I
A
K
T
L
A
S
L
S
P
E
T
S
L
F
I
I
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
E
T
A
K
E
W
---
F
L
E
----
A
-
A
K
-----
D
-----
P
S
-
A
V
A
K
H
F
V
A
L
S
T
N
T
A
K
V
K
E
F
G
I
D
P
Q
N
M
F
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
-
L
-
S
I
A
L
H
V
G
F
D
H
F
E
Q
L
L
S
G
A
H
W
M
D
Q
H
F
L
K
T
P
L
E
K
N
A
P
V
L
L
A
L
L
G
I
W
Y
I
N
C
Y
G
C
E
T
H
A
L
L
P
Y
D
Q
Y
M
H
R
F
A
A
Y
F
Q
Q
G
D
M
E
S
N
G
K
Y
I
T
K
S
G
A
R
V
D
H
Q
T
G
P
I
V
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
M
I
P
C
D
F
L
I
------
P
V
Q
T
Q
H
P
I
R
------
K
G
L
-
H
H
K
I
L
L
A
N
F
L
A
Q
T
E
A
L
M
K
G
K
L
P
E
E
A
R
K
E
L
Q
A
A
-
G
-
K
S
P
E
D
L
E
K
L
L
P
H
K
V
F
E
G
N
R
P
T
N
S
I
V
F
T
K
L
T
P
F
I
L
G
A
L
I
A
M
Y
E
H
K
I
F
V
Q
G
I
M
W
D
I
N
S
F
D
Q
W
G
V
E
L
G
K
Q
L
A
---
K
K
I
E
P
E
-
L
E
G
---
S
S
A
--------
V
-
T
S
--
H
D
S
S
T
N
G
L
I
S
F
I
K
Q
Q
R
D
--
39
PsiBlast_CBE
96.50
50%
-105
- C5 -
2CXR
5
G6PI_MOUSE
B:
[4-550]
------------------------------------------
L
T
R
N
P
-------
Q
F
Q
K
L
L
E
W
H
R
-
A
N
S
A
-
N
L
K
----
L
R
E
L
----
F
E
A
D
P
E
R
F
N
N
F
S
L
N
L
------
N
-------
T
NHGH--
I
L
-------
V
D
Y
S
K
N
L
V
S
K
E
V
M
Q
M
L
V
E
L
A
K
S
R
G
V
E
A
A
R
D
N
M
F
S
G
S
K
I
N
Y
T
E
D
R
A
V
L
H
V
A
L
R
N
R
S
N
T
P
-
I
K
-
V
D
G
K
D
V
M
P
E
V
N
R
V
L
D
K
M
K
S
F
C
Q
R
V
R
S
G
D
W
K
G
Y
T
G
K
S
I
T
D
I
I
N
I
G
I
G
G
S
D
L
G
P
L
M
V
T
E
A
L
---
K
P
Y
S
-----
K
G
G
P
R
-----
V
W
F
V
-
S
N
I
D
G
T
H
I
A
K
T
L
A
S
L
S
P
E
T
S
L
F
I
I
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
E
T
A
K
E
W
---
F
L
E
----
A
-
A
K
-----
D
-----
P
S
-
A
V
A
K
H
F
V
A
L
S
T
N
T
A
K
V
K
E
F
G
I
D
P
Q
N
M
F
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
-
L
-
S
I
A
L
H
V
G
F
D
H
F
E
Q
L
L
S
G
A
H
W
M
D
Q
H
F
L
K
T
P
L
E
K
N
A
P
V
L
L
A
L
L
G
I
W
Y
I
N
C
Y
G
C
E
T
H
A
L
L
P
Y
D
Q
Y
M
H
R
F
A
A
Y
F
Q
Q
G
D
M
E
S
N
G
K
Y
I
T
K
S
G
A
R
V
D
H
Q
T
G
P
I
V
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
M
I
P
C
D
F
L
I
------
P
V
Q
T
Q
H
P
I
R
------
K
G
L-
H
H
K
I
L
L
A
N
F
L
A
Q
T
E
A
L
M
K
G
K
L
P
E
E
A
R
K
E
L
Q
A
A
-
G
-
K
S
P
E
D
L
E
K
L
L
P
H
K
V
F
E
G
N
R
P
T
N
S
I
V
F
T
K
L
T
P
F
I
L
G
A
L
I
A
M
Y
E
H
K
I
F
V
Q
G
I
M
W
D
I
N
S
F
D
Q
W
G
V
E
L
G
K
Q
L
A
---
K
K
I
E
P
E
-
L
E
G
---
S
S
A
--------
V
-
T
S
--
H
D
S
S
T
N
G
L
I
S
F
I
K
Q
Q
R
D
--
35
PsiBlast_CBE
96.46
50%
-105
- C5 -
2CXT
5
G6PI_MOUSE
B:
[4-550]
------------------------------------------
L
T
R
N
P
-------
Q
F
Q
K
L
L
E
W
H
R
-
A
N
S
A
-
N
L
K
----
L
R
E
L
----
F
E
A
D
P
E
R
F
N
N
F
S
L
N
L
------
N
-------
T
NHGH--
I
L
-------
V
D
Y
S
K
N
L
V
S
K
E
V
M
Q
M
L
V
E
L
A
K
S
R
G
V
E
A
A
R
D
N
M
F
S
G
S
K
I
N
Y
T
E
D
R
A
V
L
H
V
A
L
R
N
R
S
N
T
P
-
I
K
-
V
D
G
K
D
V
M
P
E
V
N
R
V
L
D
K
M
K
S
F
C
Q
R
V
R
S
G
D
W
K
G
Y
T
G
K
S
I
T
D
I
I
N
I
G
I
G
G
S
D
L
G
P
L
M
V
T
E
A
L
---
K
P
Y
S
-----
K
G
G
P
R
-----
V
W
F
V
-
S
N
I
D
G
T
H
I
A
K
T
L
A
S
L
S
P
E
T
S
L
F
I
I
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
E
T
A
K
E
W
---
F
L
E
----
A
-
A
K
-----
D
-----
P
S
-
A
V
A
K
H
F
V
A
L
S
T
N
T
A
K
V
K
E
F
G
I
D
P
Q
N
M
F
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
-
L
-
S
I
A
L
H
V
G
F
D
H
F
E
Q
L
L
S
G
A
H
W
M
D
Q
H
F
L
K
T
P
L
E
K
N
A
P
V
L
L
A
L
L
G
I
W
Y
I
N
C
Y
G
C
E
T
H
A
L
L
P
Y
D
Q
Y
M
H
R
F
A
A
Y
F
Q
Q
G
D
M
E
S
N
G
K
Y
I
T
K
S
G
A
R
V
D
H
Q
T
G
P
I
V
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
M
I
P
C
D
F
L
I
------
P
V
Q
T
Q
H
P
I
R
------
K
G
L-
H
H
K
I
L
L
A
N
F
L
A
Q
T
E
A
L
M
K
G
K
L
P
E
E
A
R
K
E
L
Q
A
A
-
G
-
K
S
P
E
D
L
E
K
L
L
P
H
K
V
F
E
G
N
R
P
T
N
S
I
V
F
T
K
L
T
P
F
I
L
G
A
L
I
A
M
Y
E
H
K
I
F
V
Q
G
I
M
W
D
I
N
S
F
D
Q
W
G
V
E
L
G
K
Q
L
A
---
K
K
I
E
P
E
-
L
E
G
---
S
S
A
--------
V
-
T
S
--
H
D
S
S
T
N
G
L
I
S
F
I
K
Q
Q
R
D
--
37
PsiBlast_CBE
96.42
50%
-105
- C5 -
2CXS
5
G6PI_MOUSE
B:
[4-550]
------------------------------------------
L
T
R
N
P
-------
Q
F
Q
K
L
L
E
W
H
R
-
A
N
S
A
-
N
L
K
----
L
R
E
L
----
F
E
A
D
P
E
R
F
N
N
F
S
L
N
L
------
N
-------
T
NHGH--
I
L
-------
V
D
Y
S
K
N
L
V
S
K
E
V
M
Q
M
L
V
E
L
A
K
S
R
G
V
E
A
A
R
D
N
M
F
S
G
S
K
I
N
Y
T
E
D
R
A
V
L
H
V
A
L
R
N
R
S
N
T
P
-
I
K
-
V
D
G
K
D
V
M
P
E
V
N
R
V
L
D
K
M
K
S
F
C
Q
R
V
R
S
G
D
W
K
G
Y
T
G
K
S
I
T
D
I
I
N
I
G
I
G
G
S
D
L
G
P
L
M
V
T
E
A
L
---
K
P
Y
S
-----
K
G
G
P
R
-----
V
W
F
V
-
S
N
I
D
G
T
H
I
A
K
T
L
A
S
L
S
P
E
T
S
L
F
I
I
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
E
T
A
K
E
W
---
F
L
E
----
A
-
A
K
-----
D
-----
P
S
-
A
V
A
K
H
F
V
A
L
S
T
N
T
A
K
V
K
E
F
G
I
D
P
Q
N
M
F
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
-
L
-
S
I
A
L
H
V
G
F
D
H
F
E
Q
L
L
S
G
A
H
W
M
D
Q
H
F
L
K
T
P
L
E
K
N
A
P
V
L
L
A
L
L
G
I
W
Y
I
N
C
Y
G
C
E
T
H
A
L
L
P
Y
D
Q
Y
M
H
R
F
A
A
Y
F
Q
Q
G
D
M
E
S
N
G
K
Y
I
T
K
S
G
A
R
V
D
H
Q
T
G
P
I
V
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
M
I
P
C
D
F
L
I
------
P
V
Q
T
Q
H
P
I
R
------
K
G
L-
H
H
K
I
L
L
A
N
F
L
A
Q
T
E
A
L
M
K
G
K
L
P
E
E
A
R
K
E
L
Q
A
A
-
G
-
K
S
P
E
D
L
E
K
L
L
P
H
K
V
F
E
G
N
R
P
T
N
S
I
V
F
T
K
L
T
P
F
I
L
G
A
L
I
A
M
Y
E
H
K
I
F
V
Q
G
I
M
W
D
I
N
S
F
D
Q
W
G
V
E
L
G
K
Q
L
A
---
K
K
I
E
P
E
-
L
E
G
---
S
S
A
--------
V
-
T
S
--
H
D
S
S
T
N
G
L
I
S
F
I
K
Q
Q
R
D
--
18
PsiBlast_PDB
96.42
50%
-104
- C5 -
2CXN
4
G6PI_MOUSE
A:
[4-550]
------------------------------------------
L
T
R
N
P
-------
Q
F
Q
K
L
L
E
W
H
R
-
A
N
S
A
-
N
L
K
----
L
R
E
L
----
F
E
A
D
P
E
R
F
N
N
F
S
L
N
L
------
N
-------
T
NH
G
H
--
I
L
-------
V
D
Y
S
K
N
L
V
S
K
E
V
M
Q
M
L
V
E
L
A
K
S
R
G
V
E
A
A
R
D
N
M
F
S
G
S
K
I
N
Y
T
E
D
R
A
V
L
H
V
A
L
R
N
R
S
N
T
P
-
I
K
-
V
D
G
K
D
V
M
P
E
V
N
R
V
L
D
K
M
K
S
F
C
Q
R
V
R
S
G
D
W
K
G
Y
T
G
K
S
I
T
D
I
I
N
I
G
I
G
G
S
D
L
G
P
L
M
V
T
E
A
L
---
K
P
Y
S
-----
K
G
G
P
R
-----
V
W
F
V
-
S
N
I
D
G
T
H
I
A
K
T
L
A
S
L
S
P
E
T
S
L
F
I
I
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
E
T
A
K
E
W
---
F
L
E
----
A
-
A
K
-----
D
-----
P
S
-
A
V
A
K
H
F
V
A
L
S
T
N
T
A
K
V
K
E
F
G
I
D
P
Q
N
M
F
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
-
L
-
S
I
A
L
H
V
G
F
D
H
F
E
Q
L
L
S
G
A
H
W
M
D
Q
H
F
L
K
T
P
L
E
K
N
A
P
V
L
L
A
L
L
G
I
W
Y
I
N
C
Y
G
C
E
T
H
A
L
L
P
Y
D
Q
Y
M
H
R
F
A
A
Y
F
Q
Q
G
D
M
E
S
N
G
K
Y
I
T
K
S
G
A
R
V
D
H
Q
T
G
P
I
V
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
M
I
P
C
D
F
L
I
------
P
V
Q
T
Q
H
P
I
R
------
K
G
L
-
H
H
K
I
L
L
A
N
F
L
A
Q
T
E
A
L
M
K
G
K
L
P
E
E
A
R
K
E
L
Q
A
A
-
G
-
K
S
P
E
D
L
E
K
L
L
P
H
K
V
F
E
G
N
R
P
T
N
S
I
V
F
T
K
L
T
P
F
I
L
G
A
L
I
A
M
Y
E
H
K
I
F
V
Q
G
I
M
W
D
I
N
S
F
D
Q
W
G
V
E
L
G
K
Q
L
A
---
K
K
I
E
P
E
-
L
E
G
---
S
S
A
--------
V
-
T
S
--
H
D
S
S
T
N
G
L
I
S
F
I
K
Q
Q
R
D
--
25
PsiBlast_CBE
96.32
52%
-105
- C5 -
1XTB
2
G6PI_RABIT
B:
[4-550]
------------------------------------------
L
T
R
N
P
-------
Q
F
Q
K
L
Q
Q
W
H
R
-
E
H
G
S
-
E
L
N
----
L
R
H
L
----
F
D
T
D
K
E
R
F
N
H
F
S
L
T
L
------
N
-------
T
NHGH--
I
L
-------
L
D
Y
S
K
N
L
V
T
E
E
V
M
H
M
L
L
D
L
A
K
S
R
G
V
E
A
A
R
E
S
M
F
N
G
E
K
I
N
S
T
E
D
R
A
V
L
H
V
A
L
R
N
R
S
N
T
P
-
I
V
-
V
D
G
K
D
V
M
P
E
V
N
K
V
L
D
K
M
K
A
F
C
Q
R
V
R
S
G
D
W
K
G
Y
T
G
K
T
I
T
D
V
I
N
I
G
I
G
G
S
D
L
G
P
L
M
V
T
E
A
L
---
K
P
Y
S
-----
S
G
G
P
R
-----
V
W
F
V
-
S
N
I
D
G
T
H
I
A
K
T
L
A
C
L
N
P
E
S
S
L
F
I
I
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
K
T
A
K
D
W
---
F
L
L
----
S
-
A
K
-----
D
-----
P
S
-
T
V
A
K
H
F
V
A
L
S
T
N
T
A
K
V
K
E
F
G
I
D
P
Q
N
M
F
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
-
L
-
S
I
A
L
H
V
G
F
D
N
F
E
Q
L
L
S
G
A
H
W
M
D
Q
H
F
R
T
T
P
L
E
K
N
A
P
V
L
L
A
M
L
G
I
W
Y
I
N
C
F
G
C
E
T
Q
A
V
L
P
Y
D
Q
Y
L
H
R
F
A
A
Y
F
Q
Q
G
D
M
E
S
N
G
K
Y
I
T
K
S
G
A
R
V
D
H
Q
T
G
P
I
V
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
M
I
P
C
D
F
L
I
------
P
V
Q
T
Q
H
P
I
R
------
K
G
L-
H
H
K
I
L
L
A
N
F
L
A
Q
T
E
A
L
M
K
G
K
S
T
E
E
A
R
K
E
L
Q
A
A
-
G
-
K
S
P
E
D
L
M
K
L
L
P
H
K
V
F
E
G
N
R
P
T
N
S
I
V
F
T
K
L
T
P
F
I
L
G
A
L
I
A
M
Y
E
H
K
I
F
V
Q
G
V
V
W
D
I
N
S
F
D
Q
W
G
V
E
L
G
K
Q
L
A
---
K
K
I
E
P
E
-
L
D
G
---
S
S
P
--------
V
-
T
S
--
H
D
S
S
T
N
G
L
I
N
F
I
K
Q
Q
R
E
--
46
PsiBlast_CBE
96.31
50%
-105
- C5 -
2CVP
3
G6PI_MOUSE
B:
[4-550]
------------------------------------------
L
T
R
N
P
-------
Q
F
Q
K
L
L
E
W
H
R
-
A
N
S
A
-
N
L
K
----
L
R
E
L
----
F
E
A
D
P
E
R
F
N
N
F
S
L
N
L
------
N
-------
T
NHGH--
I
L
-------
V
D
Y
S
K
N
L
V
S
K
E
V
M
Q
M
L
V
E
L
A
K
S
R
G
V
E
A
A
R
D
N
M
F
S
G
S
K
I
N
Y
T
E
D
R
A
V
L
H
V
A
L
R
N
R
S
N
T
P
-
I
K
-
V
D
G
K
D
V
M
P
E
V
N
R
V
L
D
K
M
K
S
F
C
Q
R
V
R
S
G
D
W
K
G
Y
T
G
K
S
I
T
D
I
I
N
I
G
I
G
G
S
D
L
G
P
L
M
V
T
E
A
L
---
K
P
Y
S
-----
K
G
G
P
R
-----
V
W
F
V
-
S
N
I
D
G
T
H
I
A
K
T
L
A
S
L
S
P
E
T
S
L
F
I
I
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
E
T
A
K
E
W
---
F
L
E
----
A
-
A
K
-----
D
-----
P
S
-
A
V
A
K
H
F
V
A
L
S
T
N
T
A
K
V
K
E
F
G
I
D
P
Q
N
M
F
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
-
L
-
S
I
A
L
H
V
G
F
D
H
F
E
Q
L
L
S
G
A
H
W
M
D
Q
H
F
L
K
T
P
L
E
K
N
A
P
V
L
L
A
L
L
G
I
W
Y
I
N
C
Y
G
C
E
T
H
A
L
L
P
Y
D
Q
Y
M
H
R
F
A
A
Y
F
Q
Q
G
D
M
E
S
N
G
K
Y
I
T
K
S
G
A
R
V
D
H
Q
T
G
P
I
V
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
M
I
P
C
D
F
L
I
------
P
V
Q
T
Q
H
P
I
R
------
K
G
L-
H
H
K
I
L
L
A
N
F
L
A
Q
T
E
A
L
M
K
G
K
L
P
E
E
A
R
K
E
L
Q
A
A
-
G
-
K
S
P
E
D
L
E
K
L
L
P
H
K
V
F
E
G
N
R
P
T
N
S
I
V
F
T
K
L
T
P
F
I
L
G
A
L
I
A
M
Y
E
H
K
I
F
V
Q
G
I
M
W
D
I
N
S
F
D
Q
W
G
V
E
L
G
K
Q
L
A
---
K
K
I
E
P
E
-
L
E
G
---
S
S
A
--------
V
-
T
S
--
H
D
S
S
T
N
G
L
I
S
F
I
K
Q
Q
R
D
--
47
PsiBlast_CBE
96.22
50%
-105
- C5 -
1U0G
10
G6PI_MOUSE
B:
[4-550]
------------------------------------------
L
T
R
N
P
-------
Q
F
Q
K
L
L
E
W
H
R
-
A
N
S
A
-
N
L
K
----
L
R
E
L
----
F
E
A
D
P
E
R
F
N
N
F
S
L
N
L
------
N
-------
T
NHGH--
I
L
-------
V
D
Y
S
K
N
L
V
N
K
E
V
M
Q
M
L
V
E
L
A
K
S
R
G
V
E
A
A
R
D
N
M
F
S
G
S
K
I
N
Y
T
E
D
R
A
V
L
H
V
A
L
R
N
R
S
N
T
P
-
I
K
-
V
D
G
K
D
V
M
P
E
V
N
R
V
L
D
K
M
K
S
F
C
Q
R
V
R
S
G
D
W
K
G
Y
T
G
K
S
I
T
D
I
I
N
I
G
I
G
G
S
D
L
G
P
L
M
V
T
E
A
L
---
K
P
Y
S
-----
K
G
G
P
R
-----
V
W
F
V
-
S
N
I
D
G
T
H
I
A
K
T
L
A
S
L
S
P
E
T
S
L
F
I
I
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
E
T
A
K
E
W
---
F
L
E
----
A
-
A
K
-----
D
-----
P
S
-
A
V
A
K
H
F
V
A
L
S
T
N
T
A
K
V
K
E
F
G
I
D
P
Q
N
M
L
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
-
L
-
S
I
A
L
H
V
G
F
D
H
F
E
Q
L
L
S
G
A
H
W
M
D
Q
H
F
L
K
T
P
L
E
K
N
A
P
V
L
L
A
L
L
G
I
W
Y
I
N
C
Y
G
C
E
T
H
A
L
L
P
Y
D
Q
Y
M
H
R
F
A
A
Y
F
Q
Q
G
D
M
E
S
N
G
K
Y
I
T
K
S
G
A
R
V
D
H
Q
T
G
P
I
V
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
M
I
P
C
D
F
L
I
------
P
V
Q
T
Q
H
P
I
R
------
K
G
L-
H
H
K
I
L
L
A
N
F
L
A
Q
T
E
A
L
M
K
G
K
L
P
E
E
A
R
K
E
L
Q
A
A
-
G
-
K
S
P
E
D
L
E
K
L
L
P
H
K
V
F
E
G
N
R
P
T
N
S
I
V
F
T
K
L
T
P
F
I
L
G
A
L
I
A
M
Y
E
H
K
I
F
V
Q
G
I
M
W
D
I
N
S
F
D
Q
W
G
V
E
L
G
K
Q
L
A
---
K
K
I
E
P
E
-
L
E
G
---
S
S
A
--------
V
-
T
S
--
H
D
S
S
T
N
G
L
I
S
F
I
K
Q
Q
R
D
--
5
PsiBlast_PDB
96.18
52%
-106
- C5 -
1N8T
-
G6PI_RABIT
A:
[3-549]
------------------------------------------
L
T
R
N
P
-------
Q
F
Q
K
L
Q
Q
W
H
R
-
E
H
G
S
-
E
L
N
----
L
R
H
L
----
F
D
T
D
K
E
R
F
N
H
F
S
L
T
L
------
N
-------
T
NH
G
H
--
I
L
-------
L
D
Y
S
K
N
L
V
T
E
E
V
M
H
M
L
L
D
L
A
K
S
R
G
V
E
A
A
R
E
S
M
F
N
G
E
K
I
N
S
T
E
D
R
A
V
L
H
V
A
L
R
N
R
S
N
T
P
-
I
V
-
V
D
G
K
D
V
M
P
E
V
N
K
V
L
D
K
M
K
A
F
C
Q
R
V
R
S
G
D
W
K
G
Y
T
G
K
T
I
T
D
V
I
N
I
G
I
G
G
S
D
L
G
P
L
M
V
T
E
A
L
---
K
P
Y
S
-----
S
G
G
P
R
-----
V
W
F
V
-
S
N
I
D
G
T
H
I
A
K
T
L
A
C
L
N
P
E
S
S
L
F
I
I
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
E
T
A
K
D
W
---
F
L
L
----
S
-
A
K
-----
D
-----
P
S
-
T
V
A
K
H
F
V
A
L
S
T
N
T
A
K
V
K
E
F
G
I
D
P
Q
N
M
F
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
-
L
-
S
I
A
L
H
V
G
F
D
N
F
E
Q
L
L
S
G
A
H
W
M
D
Q
H
F
R
T
T
P
L
E
K
N
A
P
V
L
L
A
M
L
G
I
W
Y
I
N
C
F
G
C
E
T
Q
A
V
L
P
Y
D
Q
Y
L
H
R
F
A
A
Y
F
Q
Q
G
D
M
E
S
N
G
K
Y
I
T
K
S
G
A
R
V
D
H
Q
T
G
P
I
V
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
M
I
P
C
D
F
L
I
------
P
V
Q
T
Q
H
P
I
R
------
K
G
L
-
H
H
K
I
L
L
A
N
F
L
A
Q
T
E
A
L
M
K
G
K
S
T
E
E
A
R
K
E
L
Q
A
A
-
G
-
K
S
P
E
D
L
M
K
L
L
P
H
K
V
F
E
G
N
R
P
T
N
S
I
V
F
T
K
L
T
P
F
I
L
G
A
L
I
A
M
Y
E
H
K
I
F
V
Q
G
V
V
W
D
I
N
S
F
D
Q
W
G
V
E
L
G
K
Q
L
A
---
K
K
I
E
P
E
-
L
D
G
---
S
S
P
--------
V
-
T
S
--
H
D
S
S
T
N
G
L
I
N
F
I
K
Q
Q
R
E
--
7
PsiBlast_PDB
96.06
52%
-103
- C5 -
1HOX
2
G6PI_RABIT
A:
[4-550]
------------------------------------------
L
T
R
N
P
-------
Q
F
Q
K
L
Q
Q
W
H
R
-
E
H
G
S
-
E
L
N
----
L
R
H
L
----
F
D
T
D
K
E
R
F
N
H
F
S
L
T
L
------
N
-------
T
NH
G
H
--
I
L
-------
L
D
Y
S
K
N
L
V
T
E
E
V
M
H
M
L
L
D
L
A
K
S
R
G
V
E
A
A
R
E
S
M
F
N
G
E
K
I
N
S
T
E
D
R
A
V
L
H
V
A
L
R
N
R
S
N
T
P
-
I
V
-
V
D
G
K
D
V
M
P
E
V
N
K
V
L
D
K
M
K
A
F
C
Q
R
V
R
S
G
D
W
K
G
Y
T
G
K
T
I
T
D
V
I
N
I
G
I
G
G
S
D
L
G
P
L
M
V
T
E
A
L
---
K
P
Y
S
-----
S
G
G
P
R
-----
V
W
F
V
-
S
N
I
D
G
T
H
I
A
K
T
L
A
C
L
N
P
E
S
S
L
F
I
I
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
K
T
A
K
D
W
---
F
L
L
----
S
-
A
K
-----
D
-----
P
S
-
T
V
A
K
H
F
V
A
L
S
T
N
T
A
K
V
K
E
F
G
I
D
P
Q
N
M
F
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
-
L
-
S
I
A
L
H
V
G
F
D
N
F
E
Q
L
L
S
G
A
H
W
M
D
Q
H
F
R
T
T
P
L
E
K
N
A
P
V
L
L
A
M
L
G
I
W
Y
I
N
C
F
G
C
E
T
Q
A
V
L
P
Y
D
Q
Y
L
H
R
F
A
A
Y
F
Q
Q
G
D
M
E
S
N
G
K
Y
I
T
K
S
G
A
R
V
D
H
Q
T
G
P
I
V
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
M
I
P
C
D
F
L
I
------
P
V
Q
T
Q
H
P
I
R
------
K
G
L
-
H
H
K
I
L
L
A
N
F
L
A
Q
T
E
A
L
M
K
G
K
S
T
E
E
A
R
K
E
L
Q
A
A
-
G
-
K
S
P
E
D
L
M
K
L
L
P
H
K
V
F
E
G
N
R
P
T
N
S
I
V
F
T
K
L
T
P
F
I
L
G
A
L
I
A
M
Y
E
H
K
I
F
V
Q
G
V
V
W
D
I
N
S
F
D
Q
W
G
V
E
L
G
K
Q
L
A
---
K
K
I
E
P
E
-
L
D
G
---
S
S
P
--------
V
-
T
S
--
H
D
S
S
T
N
G
L
I
N
F
I
K
Q
Q
R
E
--
36
PsiBlast_CBE
96.02
50%
-104
- C5 -
2CXT
5
G6PI_MOUSE
A:
[4-550]
------------------------------------------
L
T
R
N
P
-------
Q
F
Q
K
L
L
E
W
H
R
-
A
N
S
A
-
N
L
K
----
L
R
E
L
----
F
E
A
D
P
E
R
F
N
N
F
S
L
N
L
------
N
-------
T
NH
G
H
--
I
L
-------
V
D
Y
S
K
N
L
V
S
K
E
V
M
Q
M
L
V
E
L
A
K
S
R
G
V
E
A
A
R
D
N
M
F
S
G
S
K
I
N
Y
T
E
D
R
A
V
L
H
V
A
L
R
N
R
S
N
T
P
-
I
K
-
V
D
G
K
D
V
M
P
E
V
N
R
V
L
D
K
M
K
S
F
C
Q
R
V
R
S
G
D
W
K
G
Y
T
G
K
S
I
T
D
I
I
N
I
G
I
G
G
S
D
L
G
P
L
M
V
T
E
A
L
---
K
P
Y
S
-----
K
G
G
P
R
-----
V
W
F
V
-
S
N
I
D
G
T
H
I
A
K
T
L
A
S
L
S
P
E
T
S
L
F
I
I
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
E
T
A
K
E
W
---
F
L
E
----
A
-
A
K
-----
D
-----
P
S
-
A
V
A
K
H
F
V
A
L
S
T
N
T
A
K
V
K
E
F
G
I
D
P
Q
N
M
F
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
-
L
-
S
I
A
L
H
V
G
F
D
H
F
E
Q
L
L
S
G
A
H
W
M
D
Q
H
F
L
K
T
P
L
E
K
N
A
P
V
L
L
A
L
L
G
I
W
Y
I
N
C
Y
G
C
E
T
H
A
L
L
P
Y
D
Q
Y
M
H
R
F
A
A
Y
F
Q
Q
G
D
M
E
S
N
G
K
Y
I
T
K
S
G
A
R
V
D
H
Q
T
G
P
I
V
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
M
I
P
C
D
F
L
I
------
P
V
Q
T
Q
H
P
I
R
------
K
G
L
-
H
H
K
I
L
L
A
N
F
L
A
Q
T
E
A
L
M
K
G
K
L
P
E
E
A
R
K
E
L
Q
A
A
-
G
-
K
S
P
E
D
L
E
K
L
L
P
H
K
V
F
E
G
N
R
P
T
N
S
I
V
F
T
K
L
T
P
F
I
L
G
A
L
I
A
M
Y
E
H
K
I
F
V
Q
G
I
M
W
D
I
N
S
F
D
Q
W
G
V
E
L
G
K
Q
L
A
---
K
K
I
E
P
E
-
L
E
G
---
S
S
A
--------
V
-
T
S
--
H
D
S
S
T
N
G
L
I
S
F
I
K
Q
Q
R
D
--
15
PsiBlast_PDB
96.02
51%
-103
- C5 -
1JIQ
-
G6PI_HUMAN
A:
[4-550]
------------------------------------------
L
T
R
D
P
-------
Q
F
Q
K
L
Q
Q
-
W
Y
-
R
E
H
R
S
E
L
N
----
L
R
R
L
----
F
D
A
N
K
D
R
F
N
H
F
S
L
T
L
------
N
-------
T
NH
G
H
--
I
L
-------
V
D
Y
S
K
N
L
V
T
E
D
V
M
R
M
L
V
D
L
A
K
S
R
G
V
E
A
A
R
E
R
M
F
N
G
E
K
I
N
Y
T
E
G
R
A
V
L
H
V
A
L
R
N
R
S
N
T
P
-
I
L
-
V
D
G
K
D
V
M
P
E
V
N
K
V
L
D
K
M
K
S
F
C
Q
R
V
R
S
G
D
W
K
G
Y
T
G
K
T
I
T
D
V
I
N
I
G
I
G
G
S
D
L
G
P
L
M
V
T
E
A
L
---
K
P
Y
S
-----
S
G
G
P
R
-----
V
W
Y
V
-
S
N
I
D
G
T
H
I
A
K
T
L
A
Q
L
N
P
E
S
S
L
F
I
I
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
E
T
A
K
E
W
---
F
L
Q
----
A
-
A
K
-----
D
-----
P
S
-
A
V
A
K
H
F
V
A
L
S
T
N
T
T
K
V
K
E
F
G
I
D
P
Q
N
M
F
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
-
L
-
S
I
A
L
H
V
G
F
D
N
F
E
Q
L
L
S
G
A
H
W
M
D
Q
H
F
R
T
T
P
L
E
K
N
A
P
V
L
L
A
L
L
G
I
W
Y
I
N
C
F
G
C
E
T
H
A
M
L
P
Y
D
Q
Y
L
H
R
F
A
A
Y
F
Q
Q
G
D
M
E
S
N
G
K
Y
I
T
K
S
G
T
R
V
D
H
Q
T
G
P
I
V
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
M
I
P
C
D
F
L
I
------
P
V
Q
T
Q
H
P
I
R
------
K
G
L
-
H
H
K
I
L
L
A
N
F
L
A
Q
T
E
A
L
M
R
G
K
S
T
E
E
A
R
K
E
L
Q
A
A
-
G
-
K
S
P
E
D
L
E
R
L
L
P
H
K
V
F
E
G
N
R
P
T
N
S
I
V
F
T
K
L
T
P
F
M
L
G
A
L
V
A
M
Y
E
H
K
I
F
V
Q
G
I
I
W
D
I
N
S
F
D
Q
W
G
V
E
L
G
K
Q
L
A
---
K
K
I
E
P
E
-
L
D
G
---
S
A
Q
--------
V
-
T
S
--
H
D
A
S
T
N
G
L
I
N
F
I
K
Q
Q
R
E
--
33
PsiBlast_CBE
95.97
50%
-105
- C5 -
2CXU
3
G6PI_MOUSE
B:
[4-550]
------------------------------------------
L
T
R
N
P
-------
Q
F
Q
K
L
L
E
W
H
R
-
A
N
S
A
-
N
L
K
----
L
R
E
L
----
F
E
A
D
P
E
R
F
N
N
F
S
L
N
L
------
N
-------
T
NHGH--
I
L
-------
V
D
Y
S
K
N
L
V
S
K
E
V
M
Q
M
L
V
E
L
A
K
S
R
G
V
E
A
A
R
D
N
M
F
S
G
S
K
I
N
Y
T
E
D
R
A
V
L
H
V
A
L
R
N
R
S
N
T
P
-
I
K
-
V
D
G
K
D
V
M
P
E
V
N
R
V
L
D
K
M
K
S
F
C
Q
R
V
R
S
G
D
W
K
G
Y
T
G
K
S
I
T
D
I
I
N
I
G
I
G
G
S
D
L
G
P
L
M
V
T
E
A
L
---
K
P
Y
S
-----
K
G
G
P
R
-----
V
W
F
V
-
S
N
I
D
G
T
H
I
A
K
T
L
A
S
L
S
P
E
T
S
L
F
I
I
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
E
T
A
K
E
W
---
F
L
E
----
A
-
A
K
-----
D
-----
P
S
-
A
V
A
K
H
F
V
A
L
S
T
N
T
A
K
V
K
E
F
G
I
D
P
Q
N
M
F
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
-
L
-
S
I
A
L
H
V
G
F
D
H
F
E
Q
L
L
S
G
A
H
W
M
D
Q
H
F
L
K
T
P
L
E
K
N
A
P
V
L
L
A
L
L
G
I
W
Y
I
N
C
Y
G
C
E
T
H
A
L
L
P
Y
D
Q
Y
M
H
R
F
A
A
Y
F
Q
Q
G
D
M
E
S
N
G
K
Y
I
T
K
S
G
A
R
V
D
H
Q
T
G
P
I
V
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
M
I
P
C
D
F
L
I
------
P
V
Q
T
Q
H
P
I
R
------
K
G
L-
H
H
K
I
L
L
A
N
F
L
A
Q
T
E
A
L
M
K
G
K
L
P
E
E
A
R
K
E
L
Q
A
A
-
G
-
K
S
P
E
D
L
E
K
L
L
P
H
K
V
F
E
G
N
R
P
T
N
S
I
V
F
T
K
L
T
P
F
I
L
G
A
L
I
A
M
Y
E
H
K
I
F
V
Q
G
I
M
W
D
I
N
S
F
D
Q
W
G
V
E
L
G
K
Q
L
A
---
K
K
I
E
P
E
-
L
E
G
---
S
S
A
--------
V
-
T
S
--
H
D
S
S
T
N
G
L
I
S
F
I
K
Q
Q
R
D
--
6
PsiBlast_PDB
95.97
52%
-104
- C5 -
1G98
2
G6PI_RABIT
A:
[4-550]
------------------------------------------
L
T
R
N
P
-------
Q
F
Q
K
L
Q
Q
W
H
R
-
E
H
G
S
-
E
L
N
----
L
R
H
L
----
F
D
T
D
K
E
R
F
N
H
F
S
L
T
L
------
N
-------
T
NH
G
H
--
I
L
-------
L
D
Y
S
K
N
L
V
T
E
E
V
M
H
M
L
L
D
L
A
K
S
R
G
V
E
A
A
R
E
S
M
F
N
G
E
K
I
N
S
T
E
D
R
A
V
L
H
V
A
L
R
N
R
S
N
T
P
-
I
V
-
V
D
G
K
D
V
M
P
E
V
N
K
V
L
D
K
M
K
A
F
C
Q
R
V
R
S
G
D
W
K
G
Y
T
G
K
T
I
T
D
V
I
N
I
G
I
G
G
S
D
L
G
P
L
M
V
T
E
A
L
---
K
P
Y
S
-----
S
G
G
P
R
-----
V
W
F
V
-
S
N
I
D
G
T
H
I
A
K
T
L
A
C
L
N
P
E
S
S
L
F
I
I
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
K
T
A
K
D
W
---
F
L
L
----
S
-
A
K
-----
D
-----
P
S
-
T
V
A
K
H
F
V
A
L
S
T
N
T
A
K
V
K
E
F
G
I
D
P
Q
N
M
F
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
-
L
-
S
I
A
L
H
V
G
F
D
N
F
E
Q
L
L
S
G
A
H
W
M
D
Q
H
F
R
T
T
P
L
E
K
N
A
P
V
L
L
A
M
L
G
I
W
Y
I
N
C
F
G
C
E
T
Q
A
V
L
P
Y
D
Q
Y
L
H
R
F
A
A
Y
F
Q
Q
G
D
M
E
S
N
G
K
Y
I
T
K
S
G
A
R
V
D
H
Q
T
G
P
I
V
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
M
I
P
C
D
F
L
I
------
P
V
Q
T
Q
H
P
I
R
------
K
G
L
-
H
H
K
I
L
L
A
N
F
L
A
Q
T
E
A
L
M
K
G
K
S
T
E
E
A
R
K
E
L
Q
A
A
-
G
-
K
S
P
E
D
L
M
K
L
L
P
H
K
V
F
E
G
N
R
P
T
N
S
I
V
F
T
K
L
T
P
F
I
L
G
A
L
I
A
M
Y
E
H
K
I
F
V
Q
G
V
V
W
D
I
N
S
F
D
Q
W
G
V
E
L
G
K
Q
L
A
---
K
K
I
E
P
E
-
L
D
G
---
S
S
P
--------
V
-
T
S
--
H
D
S
S
T
N
G
L
I
N
F
I
K
Q
Q
R
E
--
10
PsiBlast_PDB
95.90
52%
-105
- C5 -
1DQR
2
G6PI_RABIT
A:
[3-549]
------------------------------------------
L
T
R
N
P
-------
Q
F
Q
K
L
Q
Q
W
H
R
-
E
H
G
S
-
E
L
N
----
L
R
H
L
----
F
D
T
D
K
E
R
F
N
H
F
S
L
T
L
------
N
-------
T
NH
G
H
--
I
L
-------
L
D
Y
S
K
N
L
V
T
E
E
V
M
H
M
L
L
D
L
A
K
S
R
G
V
E
A
A
R
E
S
M
F
N
G
E
K
I
N
S
T
E
D
R
A
V
L
H
V
A
L
R
N
R
S
N
T
P
-
I
V
-
V
D
G
K
D
V
M
P
E
V
N
K
V
L
D
K
M
K
A
F
C
Q
R
V
R
S
G
D
W
K
G
Y
T
G
K
T
I
T
D
V
I
N
I
G
I
G
G
S
D
L
G
P
L
M
V
T
E
A
L
---
K
P
Y
S
-----
S
G
G
P
R
-----
V
W
F
V
-
S
N
I
D
G
T
H
I
A
K
T
L
A
C
L
N
P
E
S
S
L
F
I
I
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
K
T
A
K
D
W
---
F
L
L
----
S
-
A
K
-----
D
-----
P
S
-
T
V
A
K
H
F
V
A
L
S
T
N
T
A
K
V
K
E
F
G
I
D
P
Q
N
M
F
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
-
L
-
S
I
A
L
H
V
G
F
D
N
F
E
Q
L
L
S
G
A
H
W
M
D
Q
H
F
R
T
T
P
L
E
K
N
A
P
V
L
L
A
M
L
G
I
W
Y
I
N
C
F
G
C
E
T
Q
A
V
L
P
Y
D
Q
Y
L
H
R
F
A
A
Y
F
Q
Q
G
D
M
E
S
N
G
K
Y
I
T
K
S
G
A
R
V
D
H
Q
T
G
P
I
V
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
M
I
P
C
D
F
L
I
------
P
V
Q
T
Q
H
P
I
R
------
K
G
L
-
H
H
K
I
L
L
A
N
F
L
A
Q
T
E
A
L
M
K
G
K
S
T
E
E
A
R
K
E
L
Q
A
A
-
G
-
K
S
P
E
D
L
M
K
L
L
P
H
K
V
F
E
G
N
R
P
T
N
S
I
V
F
T
K
L
T
P
F
I
L
G
A
L
I
A
M
Y
E
H
K
I
F
V
Q
G
V
V
W
D
I
N
S
F
D
Q
W
G
V
E
L
G
K
Q
L
A
---
K
K
I
E
P
E
-
L
D
G
---
S
S
P
--------
V
-
T
S
--
H
D
S
S
T
N
G
L
I
N
F
I
K
Q
Q
R
E
--
9
PsiBlast_PDB
95.87
52%
-105
- C5 -
1XTB
2
G6PI_RABIT
A:
[4-550]
------------------------------------------
L
T
R
N
P
-------
Q
F
Q
K
L
Q
Q
W
H
R
-
E
H
G
S
-
E
L
N
----
L
R
H
L
----
F
D
T
D
K
E
R
F
N
H
F
S
L
T
L
------
N
-------
T
NH
G
H
--
I
L
-------
L
D
Y
S
K
N
L
V
T
E
E
V
M
H
M
L
L
D
L
A
K
S
R
G
V
E
A
A
R
E
S
M
F
N
G
E
K
I
N
S
T
E
D
R
A
V
L
H
V
A
L
R
N
R
S
N
T
P
-
I
V
-
V
D
G
K
D
V
M
P
E
V
N
K
V
L
D
K
M
K
A
F
C
Q
R
V
R
S
G
D
W
K
G
Y
T
G
K
T
I
T
D
V
I
N
I
G
I
G
G
S
D
L
G
P
L
M
V
T
E
A
L
---
K
P
Y
S
-----
S
G
G
P
R
-----
V
W
F
V
-
S
N
I
D
G
T
H
I
A
K
T
L
A
C
L
N
P
E
S
S
L
F
I
I
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
K
T
A
K
D
W
---
F
L
L
----
S
-
A
K
-----
D
-----
P
S
-
T
V
A
K
H
F
V
A
L
S
T
N
T
A
K
V
K
E
F
G
I
D
P
Q
N
M
F
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
-
L
-
S
I
A
L
H
V
G
F
D
N
F
E
Q
L
L
S
G
A
H
W
M
D
Q
H
F
R
T
T
P
L
E
K
N
A
P
V
L
L
A
M
L
G
I
W
Y
I
N
C
F
G
C
E
T
Q
A
V
L
P
Y
D
Q
Y
L
H
R
F
A
A
Y
F
Q
Q
G
D
M
E
S
N
G
K
Y
I
T
K
S
G
A
R
V
D
H
Q
T
G
P
I
V
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
M
I
P
C
D
F
L
I
------
P
V
Q
T
Q
H
P
I
R
------
K
G
L
-
H
H
K
I
L
L
A
N
F
L
A
Q
T
E
A
L
M
K
G
K
S
T
E
E
A
R
K
E
L
Q
A
A
-
G
-
K
S
P
E
D
L
M
K
L
L
P
H
K
V
F
E
G
N
R
P
T
N
S
I
V
F
T
K
L
T
P
F
I
L
G
A
L
I
A
M
Y
E
H
K
I
F
V
Q
G
V
V
W
D
I
N
S
F
D
Q
W
G
V
E
L
G
K
Q
L
A
---
K
K
I
E
P
E
-
L
D
G
---
S
S
P
--------
V
-
T
S
--
H
D
S
S
T
N
G
L
I
N
F
I
K
Q
Q
R
E
--
11
PsiBlast_PDB
95.70
52%
-105
- C5 -
1KOJ
2
G6PI_RABIT
A:
[3-549]
------------------------------------------
L
T
R
N
P
-------
Q
F
Q
K
L
Q
Q
W
H
R
-
E
H
G
S
-
E
L
N
----
L
R
H
L
----
F
D
T
D
K
E
R
F
N
H
F
S
L
T
L
------
N
-------
T
NH
G
H
--
I
L
-------
L
D
Y
S
K
N
L
V
T
E
E
V
M
H
M
L
L
D
L
A
K
S
R
G
V
E
A
A
R
E
S
M
F
N
G
E
K
I
N
S
T
E
D
R
A
V
L
H
V
A
L
R
N
R
S
N
T
P
-
I
V
-
V
D
G
K
D
V
M
P
E
V
N
K
V
L
D
K
M
K
A
F
C
Q
R
V
R
S
G
D
W
K
G
Y
T
G
K
T
I
T
D
V
I
N
I
G
I
G
G
S
D
L
G
P
L
M
V
T
E
A
L
---
K
P
Y
S
-----
S
G
G
P
R
-----
V
W
F
V
-
S
N
I
D
G
T
H
I
A
K
T
L
A
C
L
N
P
E
S
S
L
F
I
I
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
K
T
A
K
D
W
---
F
L
L
----
S
-
A
K
-----
D
-----
P
S
-
T
V
A
K
H
F
V
A
L
S
T
N
T
A
K
V
K
E
F
G
I
D
P
Q
N
M
F
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
-
L
-
S
I
A
L
H
V
G
F
D
N
F
E
Q
L
L
S
G
A
H
W
M
D
Q
H
F
R
T
T
P
L
E
K
N
A
P
V
L
L
A
M
L
G
I
W
Y
I
N
C
F
G
C
E
T
Q
A
V
L
P
Y
D
Q
Y
L
H
R
F
A
A
Y
F
Q
Q
G
D
M
E
S
N
G
K
Y
I
T
K
S
G
A
R
V
D
H
Q
T
G
P
I
V
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
M
I
P
C
D
F
L
I
------
P
V
Q
T
Q
H
P
I
R
------
K
G
L
-
H
H
K
I
L
L
A
N
F
L
A
Q
T
E
A
L
M
K
G
K
S
T
E
E
A
R
K
E
L
Q
A
A
-
G
-
K
S
P
E
D
L
M
K
L
L
P
H
K
V
F
E
G
N
R
P
T
N
S
I
V
F
T
K
L
T
P
F
I
L
G
A
L
I
A
M
Y
E
H
K
I
F
V
Q
G
V
V
W
D
I
N
S
F
D
Q
W
G
V
E
L
G
K
Q
L
A
---
K
K
I
E
P
E
-
L
D
G
---
S
S
P
--------
V
-
T
S
--
H
D
S
S
T
N
G
L
I
N
F
I
K
Q
Q
R
E
--
50
PsiBlast_CBE
95.59
50%
-104
- C5 -
1U0F
15
G6PI_MOUSE
A:
[4-550]
------------------------------------------
L
T
R
N
P
-------
Q
F
Q
K
L
L
E
W
H
R
-
A
N
S
A
-
N
L
K
----
L
R
E
L
----
F
E
A
D
P
E
R
F
N
N
F
S
L
N
L
------
N
-------
T
NH
G
H
--
I
L
-------
V
D
Y
S
K
N
L
V
N
K
E
V
M
Q
M
L
V
E
L
A
K
S
R
G
V
E
A
A
R
D
N
M
F
S
G
S
K
I
N
Y
T
E
D
R
A
V
L
H
V
A
L
R
N
R
S
N
T
P
-
I
K
-
V
D
G
K
D
V
M
P
E
V
N
R
V
L
D
K
M
K
S
F
C
Q
R
V
R
S
G
D
W
K
G
Y
T
G
K
S
I
T
D
I
I
N
I
G
I
G
G
S
D
L
G
P
L
M
V
T
E
A
L
---
K
P
Y
S
-----
K
G
G
P
R
-----
V
W
F
V
-
S
N
I
D
G
T
H
I
A
K
T
L
A
S
L
S
P
E
T
S
L
F
I
I
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
E
T
A
K
E
W
---
F
L
E
----
A
-
A
K
-----
D
-----
P
S
-
A
V
A
K
H
F
V
A
L
S
T
N
T
A
K
V
K
E
F
G
I
D
P
Q
N
M
L
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
-
L
-
S
I
A
L
H
V
G
F
D
H
F
E
Q
L
L
S
G
A
H
W
M
D
Q
H
F
L
K
T
P
L
E
K
N
A
P
V
L
L
A
L
L
G
I
W
Y
I
N
C
Y
G
C
E
T
H
A
L
L
P
Y
D
Q
Y
M
H
R
F
A
A
Y
F
Q
Q
G
D
M
E
S
N
G
K
Y
I
T
K
S
G
A
R
V
D
H
Q
T
G
P
I
V
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
M
I
P
C
D
F
L
I
------
P
V
Q
T
Q
H
P
I
R
------
K
G
L
-
H
H
K
I
L
L
A
N
F
L
A
Q
T
E
A
L
M
K
G
K
L
P
E
E
A
R
K
E
L
Q
A
A
-
G
-
K
S
P
E
D
L
E
K
L
L
P
H
K
V
F
E
G
N
R
P
T
N
S
I
V
F
T
K
L
T
P
F
I
L
G
A
L
I
A
M
Y
E
H
K
I
F
V
Q
G
I
M
W
D
I
N
S
F
D
Q
W
G
V
E
L
G
K
Q
L
A
---
K
K
I
E
P
E
-
L
E
G
---
S
S
A
--------
V
-
T
S
--
H
D
S
S
T
N
G
L
I
S
F
I
K
Q
Q
R
D
--
72
Fugue
95.42
51%
-105
- C5 -
1DQR
2
G6PI_RABIT
A:
[1-555]
----------------------------------------A
A
L
T
R
N
P
-------
Q
F
Q
K
L
Q
Q
-
W
H
R
E
H
G
S
-
E
L
N
----
L
R
H
L
----
F
D
T
D
K
E
R
F
N
H
F
S
L
T
L
------
N
TNH
G
---
H
------
I
L
-------
L
D
Y
S
K
N
L
V
T
E
E
V
M
H
M
L
L
D
L
A
K
S
R
G
V
E
A
A
R
E
S
M
F
N
G
E
K
I
N
S
T
E
D
R
A
V
L
H
V
A
L
R
N
R
S
N
T
P
-
I
V
-
V
D
G
K
D
V
M
P
E
V
N
K
V
L
D
K
M
K
A
F
C
Q
R
V
R
S
G
D
W
K
G
Y
T
G
K
T
I
T
D
V
I
N
I
G
I
G
G
S
D
L
G
P
L
M
V
T
E
A
L
---
K
P
Y
S
-----
S
G
G
P
R
-----
V
W
F
V
-
S
N
I
D
G
T
H
I
A
K
T
L
A
C
L
N
P
E
S
S
L
F
I
I
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
K
T
A
K
D
W
---
F
L
L
----
S
-
A
K
-----
D
-----
P
S
-
T
V
A
K
H
F
V
A
L
S
T
N
T
A
K
V
K
E
F
G
I
D
P
Q
N
M
F
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
-
L
-
S
I
A
L
H
V
G
F
D
N
F
E
Q
L
L
S
G
A
H
W
M
D
Q
H
F
R
T
T
P
L
E
K
N
A
P
V
L
L
A
M
L
G
I
W
Y
I
N
C
F
G
C
E
T
Q
A
V
L
P
Y
D
Q
Y
L
H
R
F
A
A
Y
F
Q
Q
G
D
M
E
S
N
G
K
Y
I
T
K
S
G
A
R
V
D
H
Q
T
G
P
I
V
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
M
I
P
C
D
F
L
I
------
P
V
Q
T
Q
-
H
P
I
------
R
K
G
L
H
H
K
I
L
L
A
N
F
L
A
Q
T
E
A
L
M
K
G
K
S
T
E
E
A
R
K
E
L
Q
A
A
-
G
-
K
S
P
E
D
L
M
K
L
L
P
H
K
V
F
E
G
N
R
P
T
N
S
I
V
F
T
K
L
T
P
F
I
L
G
A
L
I
A
M
Y
E
H
K
I
F
V
Q
G
V
V
W
D
I
N
S
F
D
Q
W
G
V
E
L
G
K
Q
L
A
---
K
K
I
E
P
E
-
L
D
G
---
S
S
P
--------
V
-
T
S
--
H
D
S
S
T
N
G
L
I
N
F
I
K
Q
Q
R
E
AK
20
PsiBlast_PDB
95.42
50%
-104
- C5 -
2CXP
5
G6PI_MOUSE
A:
[4-550]
------------------------------------------
L
T
R
N
P
-------
Q
F
Q
K
L
L
E
W
H
R
-
A
N
S
A
-
N
L
K
----
L
R
E
L
----
F
E
A
D
P
E
R
F
N
N
F
S
L
N
L
------
N
-------
T
NH
G
H
--
I
L
-------
V
D
Y
S
K
N
L
V
S
K
E
V
M
Q
M
L
V
E
L
A
K
S
R
G
V
E
A
A
R
D
N
M
F
S
G
S
K
I
N
Y
T
E
D
R
A
V
L
H
V
A
L
R
N
R
S
N
T
P
-
I
K
-
V
D
G
K
D
V
M
P
E
V
N
R
V
L
D
K
M
K
S
F
C
Q
R
V
R
S
G
D
W
K
G
Y
T
G
K
S
I
T
D
I
I
N
I
G
I
G
G
S
D
L
G
P
L
M
V
T
E
A
L
---
K
P
Y
S
-----
K
G
G
P
R
-----
V
W
F
V
-
S
N
I
D
G
T
H
I
A
K
T
L
A
S
L
S
P
E
T
S
L
F
I
I
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
E
T
A
K
E
W
---
F
L
E
----
A
-
A
K
-----
D
-----
P
S
-
A
V
A
K
H
F
V
A
L
S
T
N
T
A
K
V
K
E
F
G
I
D
P
Q
N
M
F
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
-
L
-
S
I
A
L
H
V
G
F
D
H
F
E
Q
L
L
S
G
A
H
W
M
D
Q
H
F
L
K
T
P
L
E
K
N
A
P
V
L
L
A
L
L
G
I
W
Y
I
N
C
Y
G
C
E
T
H
A
L
L
P
Y
D
Q
Y
M
H
R
F
A
A
Y
F
Q
Q
G
D
M
E
S
N
G
K
Y
I
T
K
S
G
A
R
V
D
H
Q
T
G
P
I
V
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
M
I
P
C
D
F
L
I
------
P
V
Q
T
Q
H
P
I
R
------
K
G
L
-
H
H
K
I
L
L
A
N
F
L
A
Q
T
E
A
L
M
K
G
K
L
P
E
E
A
R
K
E
L
Q
A
A
-
G
-
K
S
P
E
D
L
E
K
L
L
P
H
K
V
F
E
G
N
R
P
T
N
S
I
V
F
T
K
L
T
P
F
I
L
G
A
L
I
A
M
Y
E
H
K
I
F
V
Q
G
I
M
W
D
I
N
S
F
D
Q
W
G
V
E
L
G
K
Q
L
A
---
K
K
I
E
P
E
-
L
E
G
---
S
S
A
--------
V
-
T
S
--
H
D
S
S
T
N
G
L
I
S
F
I
K
Q
Q
R
D
--
26
PsiBlast_CBE
95.41
52%
-103
- C5 -
1HOX
2
G6PI_RABIT
B:
[4-550]
------------------------------------------
L
T
R
N
P
-------
Q
F
Q
K
L
Q
Q
W
H
R
-
E
H
G
S
-
E
L
N
----
L
R
H
L
----
F
D
T
D
K
E
R
F
N
H
F
S
L
T
L
------
N
-------
T
NHGH--
I
L
-------
L
D
Y
S
K
N
L
V
T
E
E
V
M
H
M
L
L
D
L
A
K
S
R
G
V
E
A
A
R
E
S
M
F
N
G
E
K
I
N
S
T
E
D
R
A
V
L
H
V
A
L
R
N
R
S
N
T
P
-
I
V
-
V
D
G
K
D
V
M
P
E
V
N
K
V
L
D
K
M
K
A
F
C
Q
R
V
R
S
G
D
W
K
G
Y
T
G
K
T
I
T
D
V
I
N
I
G
I
G
G
S
D
L
G
P
L
M
V
T
E
A
L
---
K
P
Y
S
-----
S
G
G
P
R
-----
V
W
F
V
-
S
N
I
D
G
T
H
I
A
K
T
L
A
C
L
N
P
E
S
S
L
F
I
I
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
K
T
A
K
D
W
---
F
L
L
----
S
-
A
K
-----
D
-----
P
S
-
T
V
A
K
H
F
V
A
L
S
T
N
T
A
K
V
K
E
F
G
I
D
P
Q
N
M
F
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
-
L
-
S
I
A
L
H
V
G
F
D
N
F
E
Q
L
L
S
G
A
H
W
M
D
Q
H
F
R
T
T
P
L
E
K
N
A
P
V
L
L
A
M
L
G
I
W
Y
I
N
C
F
G
C
E
T
Q
A
V
L
P
Y
D
Q
Y
L
H
R
F
A
A
Y
F
Q
Q
G
D
M
E
S
N
G
K
Y
I
T
K
S
G
A
R
V
D
H
Q
T
G
P
I
V
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
M
I
P
C
D
F
L
I
------
P
V
Q
T
Q
H
P
I
R
------
K
G
L-
H
H
K
I
L
L
A
N
F
L
A
Q
T
E
A
L
M
K
G
K
S
T
E
E
A
R
K
E
L
Q
A
A
-
G
-
K
S
P
E
D
L
M
K
L
L
P
H
K
V
F
E
G
N
R
P
T
N
S
I
V
F
T
K
L
T
P
F
I
L
G
A
L
I
A
M
Y
E
H
K
I
F
V
Q
G
V
V
W
D
I
N
S
F
D
Q
W
G
V
E
L
G
K
Q
L
A
---
K
K
I
E
P
E
-
L
D
G
---
S
S
P
--------
V
-
T
S
--
H
D
S
S
T
N
G
L
I
N
F
I
K
Q
Q
R
E
--
40
PsiBlast_CBE
95.35
50%
-103
- C5 -
2CXR
5
G6PI_MOUSE
A:
[4-550]
------------------------------------------
L
T
R
N
P
-------
Q
F
Q
K
L
L
E
W
H
R
-
A
N
S
A
-
N
L
K
----
L
R
E
L
----
F
E
A
D
P
E
R
F
N
N
F
S
L
N
L
------
N
-------
T
NH
G
H
--
I
L
-------
V
D
Y
S
K
N
L
V
S
K
E
V
M
Q
M
L
V
E
L
A
K
S
R
G
V
E
A
A
R
D
N
M
F
S
G
S
K
I
N
Y
T
E
D
R
A
V
L
H
V
A
L
R
N
R
S
N
T
P
-
I
K
-
V
D
G
K
D
V
M
P
E
V
N
R
V
L
D
K
M
K
S
F
C
Q
R
V
R
S
G
D
W
K
G
Y
T
G
K
S
I
T
D
I
I
N
I
G
I
G
G
S
D
L
G
P
L
M
V
T
E
A
L
---
K
P
Y
S
-----
K
G
G
P
R
-----
V
W
F
V
-
S
N
I
D
G
T
H
I
A
K
T
L
A
S
L
S
P
E
T
S
L
F
I
I
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
E
T
A
K
E
W
---
F
L
E
----
A
-
A
K
-----
D
-----
P
S
-
A
V
A
K
H
F
V
A
L
S
T
N
T
A
K
V
K
E
F
G
I
D
P
Q
N
M
F
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
-
L
-
S
I
A
L
H
V
G
F
D
H
F
E
Q
L
L
S
G
A
H
W
M
D
Q
H
F
L
K
T
P
L
E
K
N
A
P
V
L
L
A
L
L
G
I
W
Y
I
N
C
Y
G
C
E
T
H
A
L
L
P
Y
D
Q
Y
M
H
R
F
A
A
Y
F
Q
Q
G
D
M
E
S
N
G
K
Y
I
T
K
S
G
A
R
V
D
H
Q
T
G
P
I
V
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
M
I
P
C
D
F
L
I
------
P
V
Q
T
Q
H
P
I
R
------
K
G
L
-
H
H
K
I
L
L
A
N
F
L
A
Q
T
E
A
L
M
K
G
K
L
P
E
E
A
R
K
E
L
Q
A
A
-
G
-
K
S
P
E
D
L
E
K
L
L
P
H
K
V
F
E
G
N
R
P
T
N
S
I
V
F
T
K
L
T
P
F
I
L
G
A
L
I
A
M
Y
E
H
K
I
F
V
Q
G
I
M
W
D
I
N
S
F
D
Q
W
G
V
E
L
G
K
Q
L
A
---
K
K
I
E
P
E
-
L
E
G
---
S
S
A
--------
V
-
T
S
--
H
D
S
S
T
N
G
L
I
S
F
I
K
Q
Q
R
D
--
16
PsiBlast_PDB
95.25
51%
-101
- C5 -
1NUH
7
G6PI_HUMAN
A:
[4-550]
------------------------------------------
L
T
R
D
P
-------
Q
F
Q
K
L
Q
Q
-
W
Y
-
R
E
H
R
S
E
L
N
----
L
R
R
L
----
F
D
A
N
K
D
R
F
N
H
F
S
L
T
L
------
N
-------
T
NH
G
H
--
I
L
-------
V
D
Y
S
K
N
L
V
T
E
D
V
M
R
M
L
V
D
L
A
K
S
R
G
V
E
A
A
R
E
R
M
F
N
G
E
K
I
N
Y
T
E
G
R
A
V
L
H
V
A
L
R
N
R
S
N
T
P
-
I
L
-
V
D
G
K
D
V
M
P
E
V
N
K
V
L
D
K
M
K
S
F
C
Q
R
V
R
S
G
D
W
K
G
Y
T
G
K
T
I
T
D
V
I
N
I
G
I
G
G
S
D
L
G
P
L
M
V
T
E
A
L
---
K
P
Y
S
-----
S
G
G
P
R
-----
V
W
Y
V
-
S
N
I
D
G
T
H
I
A
K
T
L
A
Q
L
N
P
E
S
S
L
F
I
I
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
E
T
A
K
E
W
---
F
L
Q
----
A
-
A
K
-----
D
-----
P
S
-
A
V
A
K
H
F
V
A
L
S
T
N
T
T
K
V
K
E
F
G
I
D
P
Q
N
M
F
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
-
L
-
S
I
A
L
H
V
G
F
D
N
F
E
Q
L
L
S
G
A
H
W
M
D
Q
H
F
R
T
T
P
L
E
K
N
A
P
V
L
L
A
L
L
G
I
W
Y
I
N
C
F
G
C
E
T
H
A
M
L
P
Y
D
Q
Y
L
H
R
F
A
A
Y
F
Q
Q
G
D
M
E
S
N
G
K
Y
I
T
K
S
G
T
R
V
D
H
Q
T
G
P
I
V
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
M
I
P
C
D
F
L
I
------
P
V
Q
T
Q
H
P
I
R
------
K
G
L
-
H
H
K
I
L
L
A
N
F
L
A
Q
T
E
A
L
M
R
G
K
S
T
E
E
A
R
K
E
L
Q
A
A
-
G
-
K
S
P
E
D
L
E
R
L
L
P
H
K
V
F
E
G
N
R
P
T
N
S
I
V
F
T
K
L
T
P
F
M
L
G
A
L
V
A
M
Y
E
H
K
I
F
V
Q
G
I
I
W
D
I
N
S
F
D
Q
W
G
V
E
L
G
K
Q
L
A
---
K
K
I
E
P
E
-
L
D
G
---
S
A
Q
--------
V
-
T
S
--
H
D
A
S
T
N
G
L
I
N
F
I
K
Q
Q
R
E
--
27
PsiBlast_CBE
95.20
52%
-104
- C5 -
1G98
2
G6PI_RABIT
B:
[4-550]
------------------------------------------
L
T
R
N
P
-------
Q
F
Q
K
L
Q
Q
W
H
R
-
E
H
G
S
-
E
L
N
----
L
R
H
L
----
F
D
T
D
K
E
R
F
N
H
F
S
L
T
L
------
N
-------
T
NHGH--
I
L
-------
L
D
Y
S
K
N
L
V
T
E
E
V
M
H
M
L
L
D
L
A
K
S
R
G
V
E
A
A
R
E
S
M
F
N
G
E
K
I
N
S
T
E
D
R
A
V
L
H
V
A
L
R
N
R
S
N
T
P
-
I
V
-
V
D
G
K
D
V
M
P
E
V
N
K
V
L
D
K
M
K
A
F
C
Q
R
V
R
S
G
D
W
K
G
Y
T
G
K
T
I
T
D
V
I
N
I
G
I
G
G
S
D
L
G
P
L
M
V
T
E
A
L
---
K
P
Y
S
-----
S
G
G
P
R
-----
V
W
F
V
-
S
N
I
D
G
T
H
I
A
K
T
L
A
C
L
N
P
E
S
S
L
F
I
I
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
K
T
A
K
D
W
---
F
L
L
----
S
-
A
K
-----
D
-----
P
S
-
T
V
A
K
H
F
V
A
L
S
T
N
T
A
K
V
K
E
F
G
I
D
P
Q
N
M
F
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
-
L
-
S
I
A
L
H
V
G
F
D
N
F
E
Q
L
L
S
G
A
H
W
M
D
Q
H
F
R
T
T
P
L
E
K
N
A
P
V
L
L
A
M
L
G
I
W
Y
I
N
C
F
G
C
E
T
Q
A
V
L
P
Y
D
Q
Y
L
H
R
F
A
A
Y
F
Q
Q
G
D
M
E
S
N
G
K
Y
I
T
K
S
G
A
R
V
D
H
Q
T
G
P
I
V
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
M
I
P
C
D
F
L
I
------
P
V
Q
T
Q
H
P
I
R
------
K
G
L-
H
H
K
I
L
L
A
N
F
L
A
Q
T
E
A
L
M
K
G
K
S
T
E
E
A
R
K
E
L
Q
A
A
-
G
-
K
S
P
E
D
L
M
K
L
L
P
H
K
V
F
E
G
N
R
P
T
N
S
I
V
F
T
K
L
T
P
F
I
L
G
A
L
I
A
M
Y
E
H
K
I
F
V
Q
G
V
V
W
D
I
N
S
F
D
Q
W
G
V
E
L
G
K
Q
L
A
---
K
K
I
E
P
E
-
L
D
G
---
S
S
P
--------
V
-
T
S
--
H
D
S
S
T
N
G
L
I
N
F
I
K
Q
Q
R
E
--
28
PsiBlast_CBE
95.03
52%
-101
- C5 -
1KOJ
2
G6PI_RABIT
B:
[3-549]
------------------------------------------
L
T
R
N
P
-------
Q
F
Q
K
L
Q
Q
W
H
R
-
E
H
G
S
-
E
L
N
----
L
R
H
L
----
F
D
T
D
K
E
R
F
N
H
F
S
L
T
L
------
N
-------
T
NHGH--
I
L
-------
L
D
Y
S
K
N
L
V
T
E
E
V
M
H
M
L
L
D
L
A
K
S
R
G
V
E
A
A
R
E
S
M
F
N
G
E
K
I
N
S
T
E
D
R
A
V
L
H
V
A
L
R
N
R
S
N
T
P
-
I
V
-
V
D
G
K
D
V
M
P
E
V
N
K
V
L
D
K
M
K
A
F
C
Q
R
V
R
S
G
D
W
K
G
Y
T
G
K
T
I
T
D
V
I
N
I
G
I
G
G
S
D
L
G
P
L
M
V
T
E
A
L
---
K
P
Y
S
-----
S
G
G
P
R
-----
V
W
F
V
-
S
N
I
D
G
T
H
I
A
K
T
L
A
C
L
N
P
E
S
S
L
F
I
I
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
K
T
A
K
D
W
---
F
L
L
----
S
-
A
K
-----
D
-----
P
S
-
T
V
A
K
H
F
V
A
L
S
T
N
T
A
K
V
K
E
F
G
I
D
P
Q
N
M
F
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
-
L
-
S
I
A
L
H
V
G
F
D
N
F
E
Q
L
L
S
G
A
H
W
M
D
Q
H
F
R
T
T
P
L
E
K
N
A
P
V
L
L
A
M
L
G
I
W
Y
I
N
C
F
G
C
E
T
Q
A
V
L
P
Y
D
Q
Y
L
H
R
F
A
A
Y
F
Q
Q
G
D
M
E
S
N
G
K
Y
I
T
K
S
G
A
R
V
D
H
Q
T
G
P
I
V
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
M
I
P
C
D
F
L
I
------
P
V
Q
T
Q
H
P
I
R
------
K
G
L-
H
H
K
I
L
L
A
N
F
L
A
Q
T
E
A
L
M
K
G
K
S
T
E
E
A
R
K
E
L
Q
A
A
-
G
-
K
S
P
E
D
L
M
K
L
L
P
H
K
V
F
E
G
N
R
P
T
N
S
I
V
F
T
K
L
T
P
F
I
L
G
A
L
I
A
M
Y
E
H
K
I
F
V
Q
G
V
V
W
D
I
N
S
F
D
Q
W
G
V
E
L
G
K
Q
L
A
---
K
K
I
E
P
E
-
L
D
G
---
S
S
P
--------
V
-
T
S
--
H
D
S
S
T
N
G
L
I
N
F
I
K
Q
Q
R
E
--
29
PsiBlast_CBE
94.95
52%
-104
- C5 -
1DQR
2
G6PI_RABIT
B:
[3-549]
------------------------------------------
L
T
R
N
P
-------
Q
F
Q
K
L
Q
Q
W
H
R
-
E
H
G
S
-
E
L
N
----
L
R
H
L
----
F
D
T
D
K
E
R
F
N
H
F
S
L
T
L
------
N
-------
T
NHGH--
I
L
-------
L
D
Y
S
K
N
L
V
T
E
E
V
M
H
M
L
L
D
L
A
K
S
R
G
V
E
A
A
R
E
S
M
F
N
G
E
K
I
N
S
T
E
D
R
A
V
L
H
V
A
L
R
N
R
S
N
T
P
-
I
V
-
V
D
G
K
D
V
M
P
E
V
N
K
V
L
D
K
M
K
A
F
C
Q
R
V
R
S
G
D
W
K
G
Y
T
G
K
T
I
T
D
V
I
N
I
G
I
G
G
S
D
L
G
P
L
M
V
T
E
A
L
---
K
P
Y
S
-----
S
G
G
P
R
-----
V
W
F
V
-
S
N
I
D
G
T
H
I
A
K
T
L
A
C
L
N
P
E
S
S
L
F
I
I
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
K
T
A
K
D
W
---
F
L
L
----
S
-
A
K
-----
D
-----
P
S
-
T
V
A
K
H
F
V
A
L
S
T
N
T
A
K
V
K
E
F
G
I
D
P
Q
N
M
F
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
-
L
-
S
I
A
L
H
V
G
F
D
N
F
E
Q
L
L
S
G
A
H
W
M
D
Q
H
F
R
T
T
P
L
E
K
N
A
P
V
L
L
A
M
L
G
I
W
Y
I
N
C
F
G
C
E
T
Q
A
V
L
P
Y
D
Q
Y
L
H
R
F
A
A
Y
F
Q
Q
G
D
M
E
S
N
G
K
Y
I
T
K
S
G
A
R
V
D
H
Q
T
G
P
I
V
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
M
I
P
C
D
F
L
I
------
P
V
Q
T
Q
H
P
I
R
------
K
G
L-
H
H
K
I
L
L
A
N
F
L
A
Q
T
E
A
L
M
K
G
K
S
T
E
E
A
R
K
E
L
Q
A
A
-
G
-
K
S
P
E
D
L
M
K
L
L
P
H
K
V
F
E
G
N
R
P
T
N
S
I
V
F
T
K
L
T
P
F
I
L
G
A
L
I
A
M
Y
E
H
K
I
F
V
Q
G
V
V
W
D
I
N
S
F
D
Q
W
G
V
E
L
G
K
Q
L
A
---
K
K
I
E
P
E
-
L
D
G
---
S
S
P
--------
V
-
T
S
--
H
D
S
S
T
N
G
L
I
N
F
I
K
Q
Q
R
E
--
42
PsiBlast_CBE
94.90
50%
-103
- C5 -
2CXQ
5
G6PI_MOUSE
A:
[4-550]
------------------------------------------
L
T
R
N
P
-------
Q
F
Q
K
L
L
E
W
H
R
-
A
N
S
A
-
N
L
K
----
L
R
E
L
----
F
E
A
D
P
E
R
F
N
N
F
S
L
N
L
------
N
-------
T
NH
G
H
--
I
L
-------
V
D
Y
S
K
N
L
V
S
K
E
V
M
Q
M
L
V
E
L
A
K
S
R
G
V
E
A
A
R
D
N
M
F
S
G
S
K
I
N
Y
T
E
D
R
A
V
L
H
V
A
L
R
N
R
S
N
T
P
-
I
K
-
V
D
G
K
D
V
M
P
E
V
N
R
V
L
D
K
M
K
S
F
C
Q
R
V
R
S
G
D
W
K
G
Y
T
G
K
S
I
T
D
I
I
N
I
G
I
G
G
S
D
L
G
P
L
M
V
T
E
A
L
---
K
P
Y
S
-----
K
G
G
P
R
-----
V
W
F
V
-
S
N
I
D
G
T
H
I
A
K
T
L
A
S
L
S
P
E
T
S
L
F
I
I
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
E
T
A
K
E
W
---
F
L
E
----
A
-
A
K
-----
D
-----
P
S
-
A
V
A
K
H
F
V
A
L
S
T
N
T
A
K
V
K
E
F
G
I
D
P
Q
N
M
F
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
-
L
-
S
I
A
L
H
V
G
F
D
H
F
E
Q
L
L
S
G
A
H
W
M
D
Q
H
F
L
K
T
P
L
E
K
N
A
P
V
L
L
A
L
L
G
I
W
Y
I
N
C
Y
G
C
E
T
H
A
L
L
P
Y
D
Q
Y
M
H
R
F
A
A
Y
F
Q
Q
G
D
M
E
S
N
G
K
Y
I
T
K
S
G
A
R
V
D
H
Q
T
G
P
I
V
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
M
I
P
C
D
F
L
I
------
P
V
Q
T
Q
H
P
I
R
------
K
G
L
-
H
H
K
I
L
L
A
N
F
L
A
Q
T
E
A
L
M
K
G
K
L
P
E
E
A
R
K
E
L
Q
A
A
-
G
-
K
S
P
E
D
L
E
K
L
L
P
H
K
V
F
E
G
N
R
P
T
N
S
I
V
F
T
K
L
T
P
F
I
L
G
A
L
I
A
M
Y
E
H
K
I
F
V
Q
G
I
M
W
D
I
N
S
F
D
Q
W
G
V
E
L
G
K
Q
L
A
---
K
K
I
E
P
E
-
L
E
G
---
S
S
A
--------
V
-
T
S
--
H
D
S
S
T
N
G
L
I
S
F
I
K
Q
Q
R
D
--
48
PsiBlast_CBE
94.88
50%
-103
- C5 -
1U0G
14
G6PI_MOUSE
A:
[4-550]
------------------------------------------
L
T
R
N
P
-------
Q
F
Q
K
L
L
E
W
H
R
-
A
N
S
A
-
N
L
K
----
L
R
E
L
----
F
E
A
D
P
E
R
F
N
N
F
S
L
N
L
------
N
-------
T
NH
G
H
--
I
L
-------
V
D
Y
S
K
N
L
V
N
K
E
V
M
Q
M
L
V
E
L
A
K
S
R
G
V
E
A
A
R
D
N
M
F
S
G
S
K
I
N
Y
T
E
D
R
A
V
L
H
V
A
L
R
N
R
S
N
T
P
-
I
K
-
V
D
G
K
D
V
M
P
E
V
N
R
V
L
D
K
M
K
S
F
C
Q
R
V
R
S
G
D
W
K
G
Y
T
G
K
S
I
T
D
I
I
N
I
G
I
G
G
S
D
L
G
P
L
M
V
T
E
A
L
---
K
P
Y
S
-----
K
G
G
P
R
-----
V
W
F
V
-
S
N
I
D
G
T
H
I
A
K
T
L
A
S
L
S
P
E
T
S
L
F
I
I
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
E
T
A
K
E
W
---
F
L
E
----
A
-
A
K
-----
D
-----
P
S
-
A
V
A
K
H
F
V
A
L
S
T
N
T
A
K
V
K
E
F
G
I
D
P
Q
N
M
L
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F
W
D
W
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R
Y
S
L
W
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A
I
G
-
L
-
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I
A
L
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F
D
H
F
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L
L
S
G
A
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D
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T
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L
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N
A
P
V
L
L
A
L
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C
Y
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A
L
L
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A
A
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G
D
M
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S
N
G
K
Y
I
T
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S
G
A
R
V
D
H
Q
T
G
P
I
V
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
M
I
P
C
D
F
L
I
------
P
V
Q
T
Q
H
P
I
R
------
K
G
L
-
H
H
K
I
L
L
A
N
F
L
A
Q
T
E
A
L
M
K
G
K
L
P
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E
A
R
K
E
L
Q
A
A
-
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-
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E
D
L
E
K
L
L
P
H
K
V
F
E
G
N
R
P
T
N
S
I
V
F
T
K
L
T
P
F
I
L
G
A
L
I
A
M
Y
E
H
K
I
F
V
Q
G
I
M
W
D
I
N
S
F
D
Q
W
G
V
E
L
G
K
Q
L
A
---
K
K
I
E
P
E
-
L
E
G
---
S
S
A
--------
V
-
T
S
--
H
D
S
S
T
N
G
L
I
S
F
I
K
Q
Q
R
D
--
19
PsiBlast_PDB
94.73
50%
-103
- C5 -
2CXO
5
G6PI_MOUSE
A:
[4-550]
------------------------------------------
L
T
R
N
P
-------
Q
F
Q
K
L
L
E
W
H
R
-
A
N
S
A
-
N
L
K
----
L
R
E
L
----
F
E
A
D
P
E
R
F
N
N
F
S
L
N
L
------
N
-------
T
NH
G
H
--
I
L
-------
V
D
Y
S
K
N
L
V
S
K
E
V
M
Q
M
L
V
E
L
A
K
S
R
G
V
E
A
A
R
D
N
M
F
S
G
S
K
I
N
Y
T
E
D
R
A
V
L
H
V
A
L
R
N
R
S
N
T
P
-
I
K
-
V
D
G
K
D
V
M
P
E
V
N
R
V
L
D
K
M
K
S
F
C
Q
R
V
R
S
G
D
W
K
G
Y
T
G
K
S
I
T
D
I
I
N
I
G
I
G
G
S
D
L
G
P
L
M
V
T
E
A
L
---
K
P
Y
S
-----
K
G
G
P
R
-----
V
W
F
V
-
S
N
I
D
G
T
H
I
A
K
T
L
A
S
L
S
P
E
T
S
L
F
I
I
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
E
T
A
K
E
W
---
F
L
E
----
A
-
A
K
-----
D
-----
P
S
-
A
V
A
K
H
F
V
A
L
S
T
N
T
A
K
V
K
E
F
G
I
D
P
Q
N
M
F
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
-
L
-
S
I
A
L
H
V
G
F
D
H
F
E
Q
L
L
S
G
A
H
W
M
D
Q
H
F
L
K
T
P
L
E
K
N
A
P
V
L
L
A
L
L
G
I
W
Y
I
N
C
Y
G
C
E
T
H
A
L
L
P
Y
D
Q
Y
M
H
R
F
A
A
Y
F
Q
Q
G
D
M
E
S
N
G
K
Y
I
T
K
S
G
A
R
V
D
H
Q
T
G
P
I
V
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
M
I
P
C
D
F
L
I
------
P
V
Q
T
Q
H
P
I
R
------
K
G
L
-
H
H
K
I
L
L
A
N
F
L
A
Q
T
E
A
L
M
K
G
K
L
P
E
E
A
R
K
E
L
Q
A
A
-
G
-
K
S
P
E
D
L
E
K
L
L
P
H
K
V
F
E
G
N
R
P
T
N
S
I
V
F
T
K
L
T
P
F
I
L
G
A
L
I
A
M
Y
E
H
K
I
F
V
Q
G
I
M
W
D
I
N
S
F
D
Q
W
G
V
E
L
G
K
Q
L
A
---
K
K
I
E
P
E
-
L
E
G
---
S
S
A
--------
V
-
T
S
--
H
D
S
S
T
N
G
L
I
S
F
I
K
Q
Q
R
D
--
74
Fugue
94.60
49%
-103
- C5 -
4QFH
2
?
A:
[6-615]
H
H
H
M
K
D
Q
Y
L
K
D
L
T
V
H
L
N
E
SNAAPAN
T
S
M
A
V
A
S
F
N
M
P
H
E
I
T
R
R
M
R
P
L
G
V
D
A
D
TSL
T
S
C
P
S
W
R
-
R
L
-
Q
E
L
Y
-
E
I
H
GSES
I
L
K
N
----
F
D
E
C
K
D
R
F
Q
R
Y
S
L
E
V
------
D
LRSSDK
N
F
------
V
F
-------
L
D
Y
S
K
T
H
I
N
D
E
I
K
D
V
L
F
K
L
V
E
E
R
G
I
R
A
F
M
R
A
L
F
A
G
E
K
V
N
T
A
E
N
R
S
V
L
H
I
A
L
R
N
R
S
N
R
P
-
I
F
-
V
N
G
H
D
V
M
P
L
V
N
K
V
L
E
Q
M
K
K
L
S
E
K
V
R
R
G
E
W
K
G
Q
S
G
K
P
I
R
H
V
V
N
I
G
I
G
G
S
D
L
G
P
M
M
A
C
E
A
L
---
R
P
F
S
-----
D
R
R
I
S
-----
M
H
F
V
-
S
N
I
D
G
T
H
L
S
E
V
L
N
L
V
D
L
E
S
T
L
F
I
I
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
L
S
A
R
N
E
---
F
L
K
----
F
-
L
S
S
R
GIS
E
-----
A
G
-
A
V
A
K
H
F
V
A
L
S
T
N
A
E
K
V
K
E
F
G
I
D
E
E
N
M
F
Q
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
-
L
-
S
V
M
I
S
I
G
Y
D
N
F
V
E
L
L
T
G
A
H
I
M
D
E
H
F
I
N
A
P
T
E
N
N
L
P
I
I
L
A
L
V
G
I
W
Y
N
N
F
F
G
S
E
T
Q
A
I
L
P
Y
D
Q
Y
L
W
R
L
P
A
Y
L
Q
Q
L
D
M
E
S
N
G
K
G
A
T
K
N
G
R
M
V
S
T
H
T
G
P
I
I
F
G
E
A
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
L
I
P
C
D
F
I
G
------
A
I
Q
T
Q
-
N
Y
I
------
G
E
--
H
H
R
I
L
M
S
N
F
F
A
Q
T
E
A
L
M
I
G
K
T
P
E
E
V
K
R
E
L
E
S
A
-
G
G
K
S
E
D
E
I
Q
L
L
I
P
Q
K
T
F
T
G
G
R
P
S
N
S
L
L
V
K
A
L
T
P
R
A
L
G
A
I
I
A
M
Y
E
H
K
V
L
V
Q
G
A
I
W
G
I
N
S
Y
D
Q
W
G
V
E
L
G
K
L
L
A
---
K
S
I
L
L
Q
-
L
Q
P
---
G
Q
K
--------
V
-
T
N
--
H
D
S
S
T
N
G
L
I
E
L
F
N
E
R
S
H
--
73
Fugue
94.02
51%
-104
- C5 -
1DQR
2
G6PI_RABIT
A:
[1-555]
----------------------------------------A
A
L
T
R
N
P
-------
Q
F
Q
K
L
Q
Q
W
H
R
-
E
H
G
S
-
E
L
N
----
L
R
H
L
----
F
D
T
D
K
E
R
F
N
H
F
S
L
T
L
------
N
TNH
G
---
H
------
I
L
-------
L
D
Y
S
K
N
L
V
T
E
E
V
M
H
M
L
L
D
L
A
K
S
R
G
V
E
A
A
R
E
S
M
F
N
G
E
K
I
N
S
T
E
D
R
A
V
L
H
V
A
L
R
N
R
S
N
T
P
-
I
V
-
V
D
G
K
D
V
M
P
E
V
N
K
V
L
D
K
M
K
A
F
C
Q
R
V
R
S
G
D
W
K
G
Y
T
G
K
T
I
T
D
V
I
N
I
G
I
G
G
S
D
L
G
P
L
M
V
T
E
A
L
KPY
S
S
--------
G
G
P
R
-----
V
W
F
V
S
-
N
I
D
G
T
H
I
A
K
T
L
A
C
L
N
P
E
S
S
L
F
I
I
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
K
T
A
K
D
W
---
F
L
L
----
S
-
A
K
-----
D
-----
P
S
-
T
V
A
K
H
F
V
A
L
S
T
N
T
A
K
V
K
E
F
G
I
D
P
Q
N
M
F
E
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
--
L
S
I
A
L
H
V
G
F
D
N
F
E
Q
L
L
S
G
A
H
W
M
D
Q
H
F
R
T
T
P
L
E
K
N
A
P
V
L
L
A
M
L
G
I
W
Y
I
N
C
F
G
C
E
T
Q
A
V
L
P
Y
D
Q
Y
L
H
R
F
A
A
Y
F
Q
Q
G
D
M
E
S
N
G
K
Y
I
T
K
S
G
A
R
V
D
H
Q
T
G
P
I
V
W
G
E
P
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
M
I
P
C
D
F
L
I
------
P
V
Q
T
Q
-
H
P
-IRK---
G
L
--
H
H
K
I
L
L
A
N
F
L
A
Q
T
E
A
L
M
K
G
K
S
T
E
E
A
R
K
E
L
Q
A
A
-
G
-
K
S
P
E
D
L
M
K
L
L
P
H
K
V
F
E
G
N
R
P
T
N
S
I
V
F
T
K
L
T
P
F
I
L
G
A
L
I
A
M
Y
E
H
K
I
F
V
Q
G
V
V
W
D
I
N
S
F
D
Q
W
G
V
E
L
G
K
Q
L
A
---
K
K
I
E
P
E
-
L
D
G
---
S
S
P
--------
V
-
T
S
--
H
D
S
S
T
N
G
L
I
N
F
I
K
Q
Q
R
E
AK
63
PsiBlast_CBE
94.00
49%
-103
- C5 -
4QFH
2
?
B:
[57-610]
-------------------------------------------
T
S
L
T
-------
S
C
P
S
W
-
R
-
R
L
-
Q
E
L
Y
-
E
I
H
----
G
S
E
S
IL
K
N
F
D
E
C
K
D
R
F
Q
R
Y
S
L
E
V
------
D
-------
L
------
R
S
SDK
N
F
V
F
L
D
Y
S
K
T
H
I
N
D
E
I
K
D
V
L
F
K
L
V
E
E
R
G
I
R
A
F
M
R
A
L
F
A
G
E
K
V
N
T
A
E
N
R
S
V
L
H
I
A
L
R
N
R
S
N
R
P
-
I
F
-
V
N
G
H
D
V
M
P
L
V
N
K
V
L
E
Q
M
K
K
L
S
E
K
V
R
R
G
E
W
K
G
Q
S
G
K
P
I
R
H
V
V
N
I
G
I
G
G
S
D
L
G
P
M
M
A
C
E
A
L
---
R
P
F
S
-----
D
R
R
I
S
-----
M
H
F
V
-
S
N
I
D
G
T
H
L
S
E
V
L
N
L
V
D
L
E
S
T
L
F
I
I
A
S
K
T
F
T
T
Q
E
T
I
T
N
A
L
S
A
R
N
E
---
F
L
K
F
L
S
S
R
-
G
I
-----
S
-----
E
A
G
A
V
A
K
H
F
V
A
L
S
T
N
A
E
K
V
K
E
F
G
I
D
E
E
N
M
F
Q
F
W
D
W
V
G
G
R
Y
S
L
W
S
A
I
G
-
L
-
S
V
M
I
S
I
G
Y
D
N
F
V
E
L
L
T
G
A
H
I
M
D
E
H
F
I
N
A
P
T
E
N
N
L
P
I
I
L
A
L
V
G
I
W
Y
N
N
F
F
G
S
E
T
Q
A
I
L
P
Y
D
Q
Y
L
W
R
L
P
A
Y
L
Q
Q
L
D
M
E
S
N
G
K
G
A
T
K
N
G
R
M
V
S
T
H
T
G
P
I
I
F
G
E
A
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
L
I
P
C
D
F
I
G
------
A
I
Q
T
Q
-
N
Y
I
------
G
E
--
H
H
R
I
L
M
S
N
F
F
A
Q
T
E
A
L
M
I
G
K
T
P
E
E
V
K
R
E
L
E
S
A
G
G
-
K
S
E
D
E
I
Q
L
L
I
P
Q
K
T
F
T
G
G
R
P
S
N
S
L
L
V
K
A
L
T
P
R
A
L
G
A
I
I
A
M
Y
E
H
K
V
L
V
Q
G
A
I
W
G
I
N
S
Y
D
Q
W
G
V
E
L
G
K
L
L
A
---
K
S
I
L
L
Q
-
L
Q
P
---
G
Q
K
--------
V
-
T
N
--
H
D
S
S
T
N
G
L
I
E
L
F
N
E
R
S
H
--
67
PsiBlast_CBE
93.41
47%
-106
- C5 -
1T10
1
G6PI_LEIME
A:
[50-599]
------------------------------------------
L
L
N
L
P
-------
A
W
K
R
L
Q
S
-
L
Y
-
E
K
Y
G
-
N
D
S
----
I
L
S
H
----
F
E
K
D
H
Q
R
F
Q
R
Y
S
I
E
I
------
D
-------
L
HSDD
N
F
L
F
-------
L
D
Y
S
K
S
H
I
N
D
E
I
K
D
A
L
V
A
L
A
E
E
R
G
V
R
A
F
A
K
A
M
F
D
G
Q
R
V
N
S
T
E
N
R
A
V
L
H
V
A
L
R
N
R
S
N
R
P
-
I
I
-
V
D
G
K
D
V
M
S
D
V
N
N
V
L
A
Q
M
K
D
F
T
E
R
V
R
S
G
E
W
K
G
Q
T
G
K
S
I
Y
N
I
V
N
I
G
I
G
G
S
D
L
G
P
V
M
V
T
E
A
L
---
K
P
F
S
-----
K
R
D
L
H
-----
C
F
F
V
-
S
N
V
D
G
T
H
M
A
E
V
L
K
Q
V
N
L
E
E
T
I
F
I
I
A
S
K
T
F
T
T
Q
E
T
L
T
N
A
M
S
A
R
N
A
L
M
S
Y
L
K
----
E
-
N
G
IS---
T
-----
D
G
-
A
V
A
K
H
F
V
A
L
S
T
N
T
E
K
V
R
E
F
G
I
D
T
V
N
M
F
A
F
W
D
W
V
G
G
R
Y
S
V
W
S
A
I
G
-
L
-
S
V
M
L
S
I
G
Y
D
N
F
V
E
F
L
T
G
A
H
V
M
D
N
H
F
A
S
T
P
T
E
Q
N
L
P
M
M
L
A
L
V
G
I
W
Y
N
N
F
F
G
S
E
T
Q
A
V
L
P
Y
D
Q
Y
L
W
R
L
P
A
Y
L
Q
Q
L
D
M
E
S
N
G
K
G
V
T
K
K
S
G
A
V
A
V
Q
T
G
P
I
V
F
G
E
A
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
I
I
P
C
D
F
I
G
------
C
V
Q
T
Q
-
N
R
V
------
G
D
--
H
H
R
T
L
M
S
N
F
F
A
Q
T
E
A
L
M
V
G
K
N
A
E
E
V
R
Q
E
L
V
K
S
-
G
-
M
S
G
D
A
I
E
N
M
I
P
H
K
T
F
T
G
S
R
P
S
N
S
I
L
V
N
A
L
T
P
R
A
L
G
A
I
I
A
M
Y
E
H
K
V
L
V
Q
G
A
I
W
G
I
N
S
Y
D
Q
W
G
V
E
L
G
K
V
L
A
---
K
S
I
L
P
Q
-
L
K
S
---
G
N
I
--------
V
-
S
D
--
H
D
G
S
T
N
G
L
I
N
M
F
N
T
R
A
H
--
64
PsiBlast_CBE
93.39
49%
-102
- C5 -
4QFH
2
?
A:
[57-610]
-------------------------------------------
T
S
L
T
-------
S
C
P
S
W
-
R
-
R
L
-
Q
E
L
Y
-
E
I
H
----
G
S
E
S
IL
K
N
F
D
E
C
K
D
R
F
Q
R
Y
S
L
E
V
------
D
-------
L
------
R
S
SDK
N
F
V
F
L
D
Y
S
K
T
H
I
N
D
E
I
K
D
V
L
F
K
L
V
E
E
R
G
I
R
A
F
M
R
A
L
F
A
G
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K
V
N
T
A
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N
R
S
V
L
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A
L
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N
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S
N
R
P
-
I
F
-
V
N
G
H
D
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L
V
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K
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K
K
L
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K
V
R
R
G
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W
K
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K
P
I
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H
V
V
N
I
G
I
G
G
S
D
L
G
P
M
M
A
C
E
A
L
---
R
P
F
S
-----
D
R
R
I
S
-----
M
H
F
V
-
S
N
I
D
G
T
H
L
S
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V
L
N
L
V
D
L
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L
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I
A
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K
T
F
T
T
Q
E
T
I
T
N
A
L
S
A
R
N
E
---
F
L
K
F
L
S
S
R
-
G
I
-----
S
-----
E
A
G
A
V
A
K
H
F
V
A
L
S
T
N
A
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K
V
K
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F
G
I
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E
E
N
M
F
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F
W
D
W
V
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Y
S
L
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A
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-
L
-
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L
L
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A
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N
L
P
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I
L
A
L
V
G
I
W
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N
N
F
F
G
S
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T
Q
A
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L
P
Y
D
Q
Y
L
W
R
L
P
A
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L
Q
Q
L
D
M
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S
N
G
K
G
A
T
K
N
G
R
M
V
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T
H
T
G
P
I
I
F
G
E
A
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
L
I
P
C
D
F
I
G
------
A
I
Q
T
Q
-
N
Y
I
------
G
E
--
H
H
R
I
L
M
S
N
F
F
A
Q
T
E
A
L
M
I
G
K
T
P
E
E
V
K
R
E
L
E
S
A
G
G
-
K
S
E
D
E
I
Q
L
L
I
P
Q
K
T
F
T
G
G
R
P
S
N
S
L
L
V
K
A
L
T
P
R
A
L
G
A
I
I
A
M
Y
E
H
K
V
L
V
Q
G
A
I
W
G
I
N
S
Y
D
Q
W
G
V
E
L
G
K
L
L
A
---
K
S
I
L
L
Q
-
L
Q
P
---
G
Q
K
--------
V
-
T
N
--
H
D
S
S
T
N
G
L
I
E
L
F
N
E
R
S
H
--
85
HHSearch
91.68
47%
-101
- C5 -
1T10
1
G6PI_LEIME
A:
[50-602]
------------------------------------------
L
L
N
L
P
-------
A
W
K
R
L
Q
S
-
L
Y
-
E
K
Y
G
-
N
D
S
----
I
L
S
H
----
F
E
K
D
H
Q
R
F
Q
R
Y
S
I
E
I
D
LHSDD
N
-------
F
------
L
F
-------
L
D
Y
S
K
S
H
I
N
D
E
I
K
D
A
L
V
A
L
A
E
E
R
G
V
R
A
F
A
K
A
M
F
D
G
Q
R
V
N
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T
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N
R
A
V
L
H
V
A
L
R
N
R
S
N
R
P
-
I
I
-
V
D
G
K
D
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V
N
N
V
L
A
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R
V
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G
E
W
K
G
Q
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G
K
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N
I
V
N
I
G
I
G
G
S
D
L
G
P
V
M
V
T
E
A
L
---
K
P
F
S
-----
K
R
D
L
H
-----
C
F
F
V
-
S
N
V
D
G
T
H
M
A
E
V
L
K
Q
V
N
L
E
E
T
I
F
I
I
A
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K
T
F
T
T
Q
E
T
L
T
N
A
M
S
A
R
N
A
---
L
M
S
----
Y
-
L
K
-----
E
N
GIST
D
G
-
A
V
A
K
H
F
V
A
L
S
T
N
T
E
K
V
R
E
F
G
I
D
T
V
N
M
F
A
F
W
D
W
V
G
G
R
Y
S
V
W
S
A
I
G
-
L
S
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M
L
S
-
I
G
Y
D
N
F
V
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F
L
T
G
A
H
V
M
D
N
H
F
A
S
T
P
T
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N
L
P
M
M
L
A
L
V
G
I
W
Y
N
N
F
F
G
S
E
T
Q
A
V
L
P
Y
D
Q
Y
L
W
R
L
P
A
Y
L
Q
Q
L
D
M
E
S
N
G
K
G
V
T
K
K
S
G
A
V
A
V
Q
T
G
P
I
V
F
G
E
A
G
T
N
G
Q
H
A
F
Y
Q
L
I
H
Q
G
T
K
I
I
P
C
D
F
I
G
------
C
V
Q
T
Q
-
N
R
V
------
G
D
--
H
H
R
T
L
M
S
N
F
F
A
Q
T
E
A
L
M
V
G
K
N
A
E
E
V
R
Q
E
L
V
K
S
-
G
-
M
S
G
D
A
I
E
N
M
I
P
H
K
T
F
T
G
S
R
P
S
N
S
I
L
V
N
A
L
T
P
R
A
L
G
A
I
I
A
M
Y
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H
K
V
L
V
Q
G
A
I
W
G
I
N
S
Y
D
Q
W
G
V
E
L
G
K
V
L
A
---
K
S
I
L
P
Q
-
L
K
S
---
G
N
I
--------
V
-
S
D
--
H
D
G
S
T
N
G
L
I
N
M
F
N
T
R
A
H
--
69
PsiBlast_CBE
89.96
41%
-101
- C5 -
3UJH
4
?
B:
[10-561]
------------------------------------------
L
E
Q
C
A
-------
S
H
G
K
L
L
Q
-
E
K
-
K
K
L
E
-
K
L
H
----
L
R
D
L
----
L
-
K
D
E
A
R
N
D
L
L
I
R
S
T
D-----
Q
-------
G
------
V
Y
-------
L
D
F
S
R
Q
K
I
T
L
E
T
L
Q
H
L
V
N
L
A
H
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R
Q
V
P
A
M
V
K
R
M
F
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G
E
K
I
N
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T
E
N
R
A
V
L
H
V
A
L
R
M
P
E
G
S
E
P
V
H
-
V
D
G
K
N
V
L
D
E
V
H
A
V
L
R
R
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V
F
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V
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G
E
I
R
G
H
T
G
K
K
L
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N
V
I
S
I
G
I
G
G
S
Y
L
G
T
E
F
V
H
L
A
L
---
A
A
E
G
-----
Y
A
A
E
K
A
HG
R
Q
I
H
F
L
-
A
N
V
D
P
V
D
V
W
L
A
E
R
G
F
D
P
E
E
T
L
V
V
V
I
S
K
T
F
T
T
A
E
T
M
M
N
A
R
S
V
R
D
W
---
Y
L
H
----
H
Y
K
G
-----
D
-----
E
R
-
A
L
G
A
H
F
C
A
V
S
T
N
L
D
G
T
S
K
F
G
I
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D
R
V
F
G
F
W
D
W
V
G
G
R
Y
S
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T
S
A
V
G
I
L
-
P
L
A
L
Q
Y
G
Y
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V
A
Q
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F
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N
G
A
H
A
M
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F
K
T
A
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L
A
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N
L
P
M
L
M
G
L
I
S
V
W
N
A
T
F
F
G
Y
S
N
V
A
V
L
P
Y
A
Q
A
L
L
R
F
P
A
H
I
Q
Q
L
T
M
E
S
N
G
K
R
V
T
M
D
G
K
T
L
D
F
D
V
G
E
I
F
F
G
E
P
G
T
N
G
Q
H
S
F
Y
Q
L
I
H
Q
G
-
R
V
I
P
A
E
F
I
G
F
CKSQ
R
A
I
K
L
K
-
E
E
P
------
V
S
--
N
H
D
E
L
M
S
N
F
F
A
Q
P
D
A
L
A
F
G
K
T
P
E
----
E
L
R
K
E
-
G
-
I
----
P
E
K
L
V
P
H
K
T
F
P
G
D
R
P
S
C
M
L
L
F
P
E
I
S
P
F
H
I
G
Q
L
L
A
L
Y
E
H
R
V
A
V
E
G
W
L
W
G
I
N
S
F
D
Q
W
G
V
E
L
G
K
V
L
A
K
G
V
R
G
I
L
Q
K
R
R
E
G
KAP
H
E
S
--------
G
Q
S
E
--
L
C
S
S
T
R
K
I
L
E
H
Y
V
Q
Q
S
K
--
65
PsiBlast_CBE
89.18
48%
-96
- C5 -
3Q88
6
G6PI_FRATT
A:
[11-542]
------------------------------------------------------------
K
-
K
Y
-
L
K
E
Q
-
N
I
N
----
L
K
N
E
----
F
D
K
D
D
K
R
V
E
K
F
S
L
K
H
------
Q
-------
N
------
I
Y
-------
F
D
Y
S
K
N
L
I
N
D
Y
I
L
K
S
L
L
E
S
A
E
K
S
S
L
K
D
K
I
K
Q
M
F
N
G
A
K
I
N
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T
E
H
R
A
V
L
H
T
A
L
R
D
L
S
S
T
P
-
L
I
-
V
D
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Q
D
I
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Q
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V
T
K
E
K
Q
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K
E
L
V
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K
V
V
S
G
R
W
R
G
F
S
G
K
K
I
T
D
I
V
N
I
G
I
G
G
S
D
L
G
P
K
M
V
V
R
A
L
---
Q
P
Y
H
-----
C
T
D
L
K
-----
V
H
F
V
-
S
N
V
D
A
D
S
L
L
Q
A
L
H
V
V
D
P
E
T
T
L
L
I
I
A
S
K
S
F
S
T
E
E
T
L
L
N
S
I
S
A
R
E
W
---
L
L
D
----
H
-
Y
E
-----
D
-----
E
K
-
A
V
A
N
H
F
V
A
I
S
S
K
L
D
K
V
K
E
F
G
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E
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C
Y
K
M
W
D
W
V
G
G
R
Y
S
L
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I
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-
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A
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Y
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L
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V
L
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G
G
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G
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G
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H
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Q
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L
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V
D
F
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A
------
I
A
T
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H
-
H
N
Y
------
D
N
--
H
Q
Q
A
L
L
A
N
C
F
A
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A
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K
S
-
G
-
L
N
E
T
Q
A
K
E
L
A
A
H
K
V
I
P
G
N
R
P
S
T
T
I
L
L
D
E
L
S
P
Y
S
L
G
A
L
I
A
L
Y
E
H
K
I
F
V
Q
G
V
L
W
D
I
N
S
Y
D
Q
W
G
V
E
L
G
K
K
L
G
---
K
N
I
L
K
A
-
M
N
D
---
D
S
S
--------
D
-
E
Y
Q
N
L
D
D
S
T
R
Q
L
I
A
K
V
K
N
-----
70
PsiBlast_CBE
88.84
41%
-100
- C5 -
3UJH
3
?
A:
[10-561]
------------------------------------------
L
E
Q
C
A
-------
S
H
G
K
L
L
Q
-
E
K
-
K
K
L
E
-
K
L
H
----
L
R
D
L
----
L
-
K
D
E
A
R
N
D
L
L
I
R
S
T
D-----
Q
-------
G
------
V
Y
-------
L
D
F
S
R
Q
K
I
T
L
E
T
L
Q
H
L
V
N
L
A
H
E
R
Q
V
P
A
M
V
K
R
M
F
S
G
E
K
I
N
Q
T
E
N
R
A
V
L
H
V
A
L
R
M
P
E
G
S
E
P
V
H
-
V
D
G
K
N
V
L
D
E
V
H
A
V
L
R
R
I
R
V
F
S
E
K
V
R
S
G
E
I
R
G
H
T
G
K
K
L
V
N
V
I
S
I
G
I
G
G
S
Y
L
G
T
E
F
V
H
L
A
L
---
A
A
E
G
-----
Y
A
A
E
K
A
HG
R
Q
I
H
F
L
-
A
N
V
D
P
V
D
V
W
L
A
E
R
G
F
D
P
E
E
T
L
V
V
V
I
S
K
T
F
T
T
A
E
T
M
M
N
A
R
S
V
R
D
W
---
Y
L
H
----
H
Y
K
G
-----
D
-----
E
R
-
A
L
G
A
H
F
C
A
V
S
T
N
L
D
G
T
S
K
F
G
I
Q
S
D
R
V
F
G
F
W
D
W
V
G
G
R
Y
S
V
T
S
A
V
G
I
L
-
P
L
A
L
Q
Y
G
Y
D
V
A
Q
E
F
L
N
G
A
H
A
M
D
V
H
F
K
T
A
E
L
A
D
N
L
P
M
L
M
G
L
I
S
V
W
N
A
T
F
F
G
Y
S
N
V
A
V
L
P
Y
A
Q
A
L
L
R
F
P
A
H
I
Q
Q
L
T
M
E
S
N
G
K
R
V
T
M
D
G
K
T
L
D
F
D
V
G
E
I
F
F
G
E
P
G
T
N
G
Q
H
S
F
Y
Q
L
I
H
Q
G
-
R
V
I
P
A
E
F
I
G
F
CKSQ
R
A
I
K
L
K
-
E
E
P
------
V
S
--
N
H
D
E
L
M
S
N
F
F
A
Q
P
D
A
L
A
F
G
K
T
P
E
----
E
L
R
K
E
-
G
-
I
----
P
E
K
L
V
P
H
K
T
F
P
G
D
R
P
S
C
M
L
L
F
P
E
I
S
P
F
H
I
G
Q
L
L
A
L
Y
E
H
R
V
A
V
E
G
W
L
W
G
I
N
S
F
D
Q
W
G
V
E
L
G
K
V
L
A
K
G
V
R
G
I
L
Q
K
R
R
E
G
KAP
H
E
S
--------
G
Q
S
E
--
L
C
S
S
T
R
K
I
L
E
H
Y
V
Q
Q
S
K
--
66
PsiBlast_CBE
88.12
48%
-96
- C5 -
3Q7I
6
G6PI_FRATT
A:
[11-542]
------------------------------------------------------------
K
-
K
Y
-
L
K
E
Q
-
N
I
N
----
L
K
N
E
----
F
D
K
D
D
K
R
V
E
K
F
S
L
K
H
------
Q
-------
N
------
I
Y
-------
F
D
Y
S
K
N
L
I
N
D
Y
I
L
K
S
L
L
E
S
A
E
K
S
S
L
K
D
K
I
K
Q
M
F
N
G
A
K
I
N
S
T
E
H
R
A
V
L
H
T
A
L
R
D
L
S
S
T
P
-
L
I
-
V
D
G
Q
D
I
R
Q
E
V
T
K
E
K
Q
R
V
K
E
L
V
E
K
V
V
S
G
R
W
R
G
F
S
G
K
K
I
T
D
I
V
N
I
G
I
G
G
S
D
L
G
P
K
M
V
V
R
A
L
---
Q
P
Y
H
-----
C
T
D
L
K
-----
V
H
F
V
-
S
N
V
D
A
D
S
L
L
Q
A
L
H
V
V
D
P
E
T
T
L
L
I
I
A
S
K
S
F
S
T
E
E
T
L
L
N
S
I
S
A
R
E
W
---
L
L
D
----
H
-
Y
E
-----
D
-----
E
K
-
A
V
A
N
H
F
V
A
I
S
S
K
L
D
K
V
K
E
F
G
I
D
L
E
H
C
Y
K
M
W
D
W
V
G
G
R
Y
S
L
W
S
S
I
G
-
M
-
S
I
A
F
A
I
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Y
D
N
F
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K
L
L
A
G
A
Y
S
V
D
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K
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T
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F
S
K
N
I
P
V
I
M
A
L
L
A
S
Y
Y
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C
T
Y
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Q
A
L
L
P
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D
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R
L
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Y
F
V
D
Y
L
Q
Q
A
D
M
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N
G
K
S
V
N
I
A
G
E
T
V
N
Y
Q
T
G
V
V
L
W
G
G
V
G
T
N
G
Q
H
A
F
H
Q
L
L
H
Q
G
N
I
F
I
P
V
D
F
I
A
------
I
A
T
S
H
-
H
N
Y
------
D
N
--
H
Q
Q
A
L
L
A
N
C
F
A
Q
S
Q
A
L
M
F
G
Q
S
Y
D
M
V
Y
N
E
L
L
K
S
-
G
-
L
N
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T
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A
K
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A
A
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V
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P
G
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R
P
S
T
T
I
L
L
D
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L
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P
Y
S
L
G
A
L
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A
L
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K
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F
V
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G
V
L
W
D
I
N
S
Y
D
Q
W
G
V
E
L
G
K
K
L
G
---
K
N
I
L
K
A
-
M
N
D
---
D
S
S
--------
D
-
E
Y
Q
N
L
D
D
S
T
R
Q
L
I
A
K
V
K
N
-----
86
HHSearch
87.69
41%
-94
- C5 -
3UJH
3
?
A:
[10-566]
------------------------------------------
L
E
Q
C
A
-------
S
H
G
K
L
L
Q
-
E
K
-
K
K
L
E
-
K
L
H
----
L
R
D
L
----
L
K
-
D
E
A
R
N
D
L
L
I
R
S
T
D-----
Q
-------
G
------
V
Y
-------
L
D
F
S
R
Q
K
I
T
L
E
T
L
Q
H
L
V
N
L
A
H
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M
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A
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L
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A
L
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M
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S
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-
P
V
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L
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L
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V
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G
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G
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K
K
L
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N
V
I
S
I
G
I
G
G
S
Y
L
G
T
E
F
V
H
L
A
L
---
A
A
E
G
Y
A
A
E
K
A
H
G
R
Q
-----
I
H
F
L
-
A
N
V
D
P
V
D
V
W
L
A
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R
G
F
D
P
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T
L
V
V
V
I
S
K
T
F
T
T
A
E
T
M
M
N
A
R
S
V
R
D
W
---
Y
L
H
----
H
-
Y
K
-----
G
-----
D
E
R
A
L
G
A
H
F
C
A
V
S
T
N
L
D
G
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K
F
G
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Q
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D
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V
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-
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L
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L
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A
H
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A
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A
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L
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M
L
M
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L
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V
W
N
A
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F
F
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S
N
V
A
V
L
P
Y
A
Q
A
L
L
R
F
P
A
H
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Q
Q
L
T
M
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S
N
G
K
R
V
T
M
D
G
K
T
L
D
F
D
V
G
E
I
F
F
G
E
P
G
T
N
G
Q
H
S
F
Y
Q
L
I
H
Q
G
R
-
V
I
P
A
E
F
I
G
------
F
C
K
S
Q
-
R
A
I
K
L
KEEP
V
S
--
N
H
D
E
L
M
S
N
F
F
A
Q
P
D
A
L
A
F
G
K
T
P
E
E
L
R
K
E
----------
G
I
P
E
K
L
V
P
H
K
T
F
P
G
D
R
P
S
C
M
L
L
F
P
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F
H
I
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Q
L
L
A
L
Y
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R
V
A
V
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G
W
L
W
G
I
N
S
F
D
Q
W
G
V
E
L
G
K
V
L
A
---
K
G
V
R
G
I
-
L
Q
K
---
R
R
E
GKAPHESG
Q
-
S
E
--
L
C
S
S
T
R
K
I
L
E
H
Y
V
Q
Q
S
K
--