@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_1098: (2015-12-20 )
MSAILETKGLKKTYQNHLVLDGINFTLNKGEVAVILGPSGCGKSTFLKCLNGLEKIDEGEILFENTNLNTPSTNWNQMRQKIGMVFQNYELFPHLNVLDNILLAPLKVQKRSKDEVLSQAVELLKRVGLEHKQQAYPKELSGGQKQRVAIVRSLCMRPKIMLFDEVTASLDPEMVKEVLEVILELAKTGMSMVIVTHEMKFAQKIASKIVFFDSGKIAEENSAKEFFNHPKSQRAQKFLETFHFLGSC
Atome Classification :
(25 SA)
.........10.....-.----..20........30........40........50........60....-------------....70...--.....80........90........100.......110---........120....---------...130....-...140.......150....-...160.......170.......180...-....190.......200.......210..-.....220.......230-........240......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MS
A
I
L
ETK
G
L
K
K
T
Y
QN-
H
----
L
V
LDG
I
N
F
T
LNKG
E
V
A
V
I
LGPSGC
G
K
S
T
F
L
K
C
L
N
G
L
E
KIDEG
E
I
L
F
EN-------------TNLNTPST
N
--
W
N
Q
M
R
Q
K
I
G
M
V
F
QNYELFP
H
L
N
V
L
D
N
I
L
LAP
L
K
VQK-R---
S
K
D
E
V
L
S
Q
A
V
E
L
L
K
R---------VG
L
E
H
K
Q
QAY-
P
K
ELSGG
Q
K
Q
R
V
A
I
V
R
S
L
CM-RP
K
I
M
L
F
D
E
V
TASL
D
P
E
M
V
K
E
V
L
E
V
I
L
E
L
-
A
KTG
M
S
M
V
I
V
T
H
E
M
K
F
A
Q
K
I
A
S
K
I
V
F
FDS-GKIAEEN
S
A
K
E
F
FNH
P
K
--
S
Q
R
A
Q
K
F
L
E
T
F
H
F
LGSC
21
PsiBlast_CBE
95.23
52%
-125
- C1 -
3C4J
4
?
B:
[22-259]
-
L
Q
M
I
D
V
H
Q
L
K
K
S
F
G
S
-
L
----
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
-------------
I
N
L
K
A
K
D
T
N
--
L
N
K
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
-
W
---
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
---------
V
G
L
K
D
K
A
H
A
Y
-
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
-
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
-
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
--
H
E
R
T
K
A
F
L
S
K
V
F
-----
26
PsiBlast_CBE
95.12
52%
-123
- C1 -
2OLK
1
?
D:
[22-259]
-
L
Q
M
I
D
V
H
Q
L
K
K
S
F
G
S
-
L
----
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
-------------
I
N
L
K
A
K
D
T
N
--
L
N
K
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
-
W
---
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
---------
V
G
L
K
D
K
A
H
A
Y
-
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
-
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
-
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
--
H
E
R
T
K
A
F
L
S
K
V
F
-----
24
PsiBlast_CBE
94.21
52%
-122
- C1 -
2OUK
1
?
C:
[22-259]
-
L
Q
M
I
D
V
H
Q
L
K
K
S
F
G
S
-
L
----
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
-------------
I
N
L
K
A
K
D
T
N
--
L
N
K
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
-
W
---
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
---------
V
G
L
K
D
K
A
H
A
Y
-
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
-
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
-
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
--
H
E
R
T
K
A
F
L
S
K
V
F
-----
123
HHSearch
94.20
52%
-121
- C1 -
2OLJ
4
?
A:
[22-260]
-
L
Q
M
I
D
V
H
Q
L
K
K
S
F
G
S
-
L
----
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
-------------
I
N
L
K
A
K
D
T
N
--
L
N
K
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
-
W
---
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
---------
V
G
L
K
D
K
A
H
A
Y
-
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
-
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
-
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
--
H
E
R
T
K
A
F
L
S
K
V
F
-----
3
PsiBlast_PDB
94.15
52%
-124
- C1 -
2OUK
1
?
A:
[22-259]
-
L
Q
M
I
D
V
H
Q
L
K
K
S
F
G
S
-
L
----
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
-------------
I
N
L
K
A
K
D
T
N
--
L
N
K
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
-
W
---
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
---------
V
G
L
K
D
K
A
H
A
Y
-
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
-
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
-
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
--
H
E
R
T
K
A
F
L
S
K
V
F
-----
28
PsiBlast_CBE
94.04
52%
-119
- C1 -
2OLK
2
?
B:
[22-259]
-
L
Q
M
I
D
V
H
Q
L
K
K
S
F
G
S
-
L
----
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
-------------
I
N
L
K
A
K
D
T
N
--
L
N
K
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
-
W
---
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
---------
V
G
L
K
D
K
A
H
A
Y
-
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
-
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
-
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
--
H
E
R
T
K
A
F
L
S
K
V
F
-----
1
PsiBlast_PDB
93.60
52%
-122
- C1 -
2OLJ
4
?
A:
[22-259]
-
L
Q
M
I
D
V
H
Q
L
K
K
S
F
G
S
-
L
----
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
-------------
I
N
L
K
A
K
D
T
N
--
L
N
K
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
-
W
---
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
---------
V
G
L
K
D
K
A
H
A
Y
-
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
-
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
-
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
--
H
E
R
T
K
A
F
L
S
K
V
F
-----
30
PsiBlast_CBE
93.51
52%
-123
- C1 -
3C41
3
?
K:
[3-238]
---
M
I
D
V
H
Q
L
K
K
S
F
G
S
-
L
----
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
-------------
I
N
L
K
A
K
D
T
N
--
L
N
K
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
-
W
---
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
---------
V
G
L
K
D
K
A
H
A
Y
-
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
-
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
-
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
--
H
E
R
T
K
A
F
L
S
K
V
F
-----
23
PsiBlast_CBE
93.42
52%
-121
- C1 -
2OUK
2
?
D:
[23-259]
--
Q
M
I
D
V
H
Q
L
K
K
S
F
G
S
-
L
----
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
-------------
I
N
L
K
A
K
D
T
N
--
L
N
K
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
-
W
---
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
---------
V
G
L
K
D
K
A
H
A
Y
-
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
-
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
-
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
--
H
E
R
T
K
A
F
L
S
K
V
F
-----
2
PsiBlast_PDB
93.26
52%
-119
- C1 -
2OLK
1
?
A:
[22-259]
-
L
Q
M
I
D
V
H
Q
L
K
K
S
F
G
S
-
L
----
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
-------------
I
N
L
K
A
K
D
T
N
--
L
N
K
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
-
W
---
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
---------
V
G
L
K
D
K
A
H
A
Y
-
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
-
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
-
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
--
H
E
R
T
K
A
F
L
S
K
V
F
-----
6
PsiBlast_PDB
93.08
52%
-119
- C1 -
3C41
3
?
J:
[3-238]
---
M
I
D
V
H
Q
L
K
K
S
F
G
S
-
L
----
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
-------------
I
N
L
K
A
K
D
T
N
--
L
N
K
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
-
W
---
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
---------
V
G
L
K
D
K
A
H
A
Y
-
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
-
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
-
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
--
H
E
R
T
K
A
F
L
S
K
V
F
-----
22
PsiBlast_CBE
93.01
52%
-123
- C1 -
2Q0H
4
?
B:
[22-259]
-
L
Q
M
I
D
V
H
Q
L
K
K
S
F
G
S
-
L
----
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
-------------
I
N
L
K
A
K
D
T
N
--
L
N
K
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
-
W
---
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
---------
V
G
L
K
D
K
A
H
A
Y
-
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
-
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
-
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
--
H
E
R
T
K
A
F
L
S
K
V
F
-----
25
PsiBlast_CBE
92.92
52%
-122
- C1 -
2OUK
2
?
B:
[23-259]
--
Q
M
I
D
V
H
Q
L
K
K
S
F
G
S
-
L
----
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
-------------
I
N
L
K
A
K
D
T
N
--
L
N
K
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
-
W
---
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
---------
V
G
L
K
D
K
A
H
A
Y
-
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
-
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
-
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
--
H
E
R
T
K
A
F
L
S
K
V
F
-----
27
PsiBlast_CBE
92.41
52%
-120
- C1 -
2OLK
1
?
C:
[22-259]
-
L
Q
M
I
D
V
H
Q
L
K
K
S
F
G
S
-
L
----
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
-------------
I
N
L
K
A
K
D
T
N
--
L
N
K
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
-
W
---
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
---------
V
G
L
K
D
K
A
H
A
Y
-
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
-
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
-
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
--
H
E
R
T
K
A
F
L
S
K
V
F
-----
4
PsiBlast_PDB
92.23
52%
-118
- C1 -
2Q0H
4
?
A:
[23-259]
--
Q
M
I
D
V
H
Q
L
K
K
S
F
G
S
-
L
----
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
-------------
I
N
L
K
A
K
D
T
N
--
L
N
K
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
-
W
---
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
---------
V
G
L
K
D
K
A
H
A
Y
-
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
-
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
-
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
--
H
E
R
T
K
A
F
L
S
K
V
F
-----
5
PsiBlast_PDB
91.75
52%
-118
- C1 -
3C4J
3
?
A:
[22-259]
-
L
Q
M
I
D
V
H
Q
L
K
K
S
F
G
S
-
L
----
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
-------------
I
N
L
K
A
K
D
T
N
--
L
N
K
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
-
W
---
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
---------
V
G
L
K
D
K
A
H
A
Y
-
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
-
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
-
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
--
H
E
R
T
K
A
F
L
S
K
V
F
-----
29
PsiBlast_CBE
91.09
52%
-118
- C1 -
2OLJ
3
?
B:
[22-259]
-
L
Q
M
I
D
V
H
Q
L
K
K
S
F
G
S
-
L
----
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
-------------
I
N
L
K
A
K
D
T
N
--
L
N
K
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
-
W
---
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
---------
V
G
L
K
D
K
A
H
A
Y
-
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
-
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
-
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
--
H
E
R
T
K
A
F
L
S
K
V
F
-----
35
PsiBlast_CBE
90.71
46%
-118
- C1 -
4U02
1
?
B:
[1-239]
M
E
P
I
I
R
I
R
N
L
H
K
W
F
G
P
-
L
----
H
V
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
Q
E
G
E
V
V
V
D
G
-------------
L
S
V
K
D
-
D
R
A
--
L
R
E
I
R
R
E
V
G
M
V
F
Q
Q
F
N
L
F
P
H
M
T
V
L
E
N
V
T
L
A
P
M
R
V
R
R
-
W
---
P
R
E
K
A
E
K
K
A
L
E
L
L
E
R
---------
V
G
I
L
D
Q
A
R
K
Y
-
P
A
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
V
M
R
D
L
-
A
Q
G
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
D
G
-
G
Q
I
V
E
E
G
R
P
E
E
I
F
T
R
P
K
--
E
E
R
T
R
S
F
L
Q
R
V
L
H
----
34
PsiBlast_CBE
90.16
46%
-121
- C1 -
4U02
1
?
C:
[1-239]
M
E
P
I
I
R
I
R
N
L
H
K
W
F
G
P
-
L
----
H
V
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
Q
E
G
E
V
V
V
D
G
-------------
L
S
V
K
D
-
D
R
A
--
L
R
E
I
R
R
E
V
G
M
V
F
Q
Q
F
N
L
F
P
H
M
T
V
L
E
N
V
T
L
A
P
M
R
V
R
R
-
W
---
P
R
E
K
A
E
K
K
A
L
E
L
L
E
R
---------
V
G
I
L
D
Q
A
R
K
Y
-
P
A
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
V
M
R
D
L
-
A
Q
G
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
D
G
-
G
Q
I
V
E
E
G
R
P
E
E
I
F
T
R
P
K
--
E
E
R
T
R
S
F
L
Q
R
V
L
H
----
12
PsiBlast_PDB
89.87
46%
-120
- C1 -
4U00
3
?
A:
[3-239]
--
P
I
I
R
I
R
N
L
H
K
W
F
G
P
-
L
----
H
V
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
Q
E
G
E
V
V
V
D
G
-------------
L
S
V
K
D
-
D
R
A
--
L
R
E
I
R
R
E
V
G
M
V
F
Q
Q
F
N
L
F
P
H
M
T
V
L
E
N
V
T
L
A
P
M
R
V
R
R
-
W
---
P
R
E
K
A
E
K
K
A
L
E
L
L
E
R
---------
V
G
I
L
D
Q
A
R
K
Y
-
P
A
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
V
M
R
D
L
-
A
Q
G
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
D
G
-
G
Q
I
V
E
E
G
R
P
E
E
I
F
T
R
P
K
--
E
E
R
T
R
S
F
L
Q
R
V
L
H
----
107
Fugue
77.73
40%
-124
- C1 -
1B0U
4
HISP_SALTY
A:
[5-261]
--
N
K
L
H
V
I
D
L
H
K
R
Y
G
G
H
E
----
V
L
K
-
G
V
S
L
Q
A
R
A
G
D
V
I
S
I
I
G
S
S
G
S
G
K
S
T
F
L
R
C
I
N
F
L
E
K
P
S
E
G
A
I
I
V
N
G
QNI
N
L
V
R
D
KDGQL
K
V
A
D
K
N
Q
L
R
--
L
L
R
T
-
R
-
L
T
M
V
F
Q
H
F
N
L
W
S
H
M
T
V
L
E
N
V
M
E
A
P
I
Q
V
L
-G
L
---
S
K
H
D
A
R
E
R
A
L
K
Y
L
A
K
V
GIDERAQG--------
K
Y
-
P
V
H
L
S
G
G
Q
Q
Q
R
V
S
I
A
R
A
L
A
M
E-
P
D
V
L
L
F
D
E
P
T
S
A
L
D
P
E
L
V
G
E
V
L
R
I
M
Q
Q
L
-
A
E
E
G
K
T
M
V
V
V
T
H
E
M
G
F
A
R
H
V
S
S
H
V
I
F
L
H
-Q
G
K
I
E
E
E
G
D
P
E
Q
V
F
G
N
P
-QS
P
R
L
Q
Q
F
L
K
G
S
L
K
K
L
E
H
-
89
PsiBlast_CBE
73.85
34%
-120
- C1 -
3TIF
7
Y796_METJA
B:
[1-232]
---
M
V
K
L
K
N
V
T
K
T
Y
K
M
-
G
EEII
Y
A
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
-------------
I
K
T
N
D
L
D
D
D
EL
T
K
I
R
R
D
K
I
G
F
V
F
Q
Q
F
N
L
I
P
L
L
T
A
L
E
N
V
E
L
-
P
L
I
F
K
Y
-
R
GAM
S
G
E
E
R
R
K
R
A
L
E
C
L
K
M
---------
A
E
L
E
E
R
F
A
N
H
K
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
-
N
P
P
I
I
L
A
D
Q
P
T
W
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
D
G
K
T
V
V
V
V
T
H
D
I
N
V
A
-
R
F
G
E
R
I
I
Y
L
K
D
-
G
E
V
E
R
E
E
K
L
R
G
F
------------------------
90
PsiBlast_CBE
73.08
34%
-115
- C1 -
3TIF
7
Y796_METJA
A:
[1-230]
---
M
V
K
L
K
N
V
T
K
T
Y
K
M
-
G
E
E
I
I
Y
A
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
-------------
I
K
T
N
D
L
D
D
D
E
L
T
K
I
R
R
D
K
I
G
F
V
F
Q
Q
F
N
L
I
P
L
L
T
A
L
E
N
V
E
L
-
P
L
I
F
K
Y
-
R
G
A
M
S
G
E
E
R
R
K
R
A
L
E
C
L
K
M
---------
A
E
L
E
E
R
F
A
N
H
K
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
-
N
P
P
I
I
L
A
D
Q
P
T
W
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
D
G
K
T
V
V
V
V
T
H
D
I
N
V
A
-
R
F
G
E
R
I
I
Y
L
K
D
-
G
E
V
E
R
E
E
K
L
R
--------------------------
87
PsiBlast_CBE
72.33
34%
-120
- C1 -
1L2T
4
Y796_METJA
B:
[1-232]
---
M
I
K
L
K
N
V
T
K
T
Y
K
M
-
G
EEII
Y
A
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
-------------
I
K
T
N
D
L
D
D
D
EL
T
K
I
R
R
D
K
I
G
F
V
F
Q
Q
F
N
L
I
P
L
L
T
A
L
E
N
V
E
L
-
P
L
I
F
K
Y
-
R
GAM
S
G
E
E
R
R
K
R
A
L
E
C
L
K
M
---------
A
E
L
E
E
R
F
A
N
H
K
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
-
N
P
P
I
I
L
A
D
Q
P
T
G
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
D
G
K
T
V
V
V
V
T
H
D
I
N
V
A
-
R
F
G
E
R
I
I
Y
L
K
D
-
G
E
V
E
R
E
E
K
L
R
G
F
------------------------
88
PsiBlast_CBE
70.76
34%
-119
- C1 -
1L2T
4
Y796_METJA
A:
[1-230]
---
M
I
K
L
K
N
V
T
K
T
Y
K
M
-
G
E
E
I
I
Y
A
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
-------------
I
K
T
N
D
L
D
D
D
E
L
T
K
I
R
R
D
K
I
G
F
V
F
Q
Q
F
N
L
I
P
L
L
T
A
L
E
N
V
E
L
-
P
L
I
F
K
Y
-
R
G
A
M
S
G
E
E
R
R
K
R
A
L
E
C
L
K
M
---------
A
E
L
E
E
R
F
A
N
H
K
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
-
N
P
P
I
I
L
A
D
Q
P
T
G
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
D
G
K
T
V
V
V
V
T
H
D
I
N
V
A
-
R
F
G
E
R
I
I
Y
L
K
D
-
G
E
V
E
R
E
E
K
L
R
--------------------------