@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_1105: (2015-12-20 )
MQKRVVILLLDSFGIGASEDAKDFGDLGANTLGNIAKACFNNLADSNDRNGVLKLPNLEGLGLGLSALKAANELPLGFQLKPNLIGAYAYAKELSSAKDTISGHWEMMGAPVLFEWGYFKDKNDSFPKEILDEIMHKTKIKGYLGNCHASGTEIIKDLGEKHLETLYPIFYTSADSVFQIAAHEERFGLDHLYALCEEAFQILEPLKIARVIARPFIGTNRENFKRTANRKDYAIKPHKKLLFETFIEEKQGEVISIGKIADIYAHVGITQKFKAGSLMELCDVTLDQVKNAPNNSLIFTNFVHFDSDYGHRRDVSGYANALEYFDARLKEVLDNLRENDLLILCADHGCDPSFKGTDHTREYIPVLFYHKDLQPAFLGKSETFADIGQSIAYFLGLSPLDYGKNLLNFKGQP
Atome Classification :
(27 SA)
.........10........20........30........40........50........60...-.....70.--.......80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200..--.-.....210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370..--...--..380.......390.......400.......410.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MQ
K
R
V
V
I
L
L
LDSFGIGAS
E
D
A
K
D
F
G
D
L
G
A
N
T
L
G
N
I
A
K
A
C
F
N
NLADSNDRNG
V
L
KLPNLEGL
G
L
G
-
L
S
A
L
K
A
A
N--ELPLGFQLKP
N
L
I
G
A
Y
A
Y
A
K
E
L
S
SAKDTISGHWEMMGA
P
V
L
F
EWGYFKDKNDS
F
P
K
E
I
L
D
E
I
M
H
K
T
K
I
K
G
YLGNCHA
S
G
T
E
I
I
K
D
L
G
E
K
H
L
E
T
L
Y
P
I
F
YTSADSV
F
Q
I
A
A
H
E
E
RF
G
L
D
H
L
Y
A
L
C
E
E
A
F
Q
-
I
L
--
E
-
P
L
K
I
A
R
V
I
A
RPFIGT
N
R
E
N
F
K
R
TANRKDYAIK
P
H
K
K
L
L
F
E
T
F
I
E
EKQG
E
V
I
S
I
G
K
I
A
D
I
Y
A
HVGITQKFKAG
S
L
M
E
L
C
D
V
T
L
D
Q
VKNAPNN
S
L
I
F
T
N
F
V
H
FDSDYGHRRDV
S
G
Y
A
N
A
L
E
Y
F
D
A
R
L
K
E
V
L
D
N
LREN
D
L
L
I
L
CADHGCDPSFKGTDHT
R
E
Y
I
P
V
L
F
Y
HKDL
Q
--
P
A
F--LGKS
E
T
F
A
D
I
G
Q
S
I
A
Y
F
LGL
S
P
L
D
Y
G
K
N
L
LNFKGQP
37
PsiBlast_CBE
98.49
43%
-111
- C6 -
4LRE
4
DEOB_BACCR
B:
[27-412]
--
K
R
I
F
L
V
V
M
D
S
V
G
I
G
E
A
P
D
A
E
Q
F
G
D
L
G
S
D
T
I
G
H
I
A
E
H
M
----------
N
G
-
L
Q
M
P
N
M
V
K
L
G
L
G
N
I
R
E
M
K
G
I
S
KV
E
K
P
L
G
Y
---------
Y
T
K
M
Q
E
K
S
T
G
K
D
T
M
T
G
H
W
E
I
M
G
L
Y
I
D
T
P
F
Q
V
F
P
E
---
G
F
P
K
E
L
L
D
E
L
E
E
K
T
G
R
K
-
I
I
G
N
K
P
A
S
G
T
E
I
L
D
E
L
G
Q
E
Q
M
E
T
G
S
L
I
V
Y
T
S
A
D
S
V
L
Q
I
A
A
H
E
E
V
V
P
L
D
E
L
Y
K
I
C
K
I
A
R
E
-
L
T
LD
E
-
K
Y
M
V
G
R
V
I
A
R
P
F
V
G
-
E
P
G
N
F
T
R
T
P
N
R
H
D
Y
A
L
K
P
F
G
R
T
V
M
N
E
-
L
K
D
S
D
Y
D
V
I
A
I
G
K
I
S
D
I
Y
D
G
E
G
V
T
E
S
L
R
T
K
S
N
M
D
G
M
D
K
L
V
D
T
L
-
N
M
D
F
T
G
L
S
F
L
N
L
V
D
F
D
A
L
F
G
H
R
R
D
P
Q
G
Y
G
E
A
L
Q
E
Y
D
A
R
L
P
E
V
F
A
K
L
K
E
D
D
L
L
L
I
T
A
D
H
G
N
D
P
I
H
P
G
T
D
H
T
R
E
Y
V
P
L
L
A
Y
S
P
S
M
K
--
E
G
G
QE
L
P
L
R
Q
T
F
A
D
I
G
A
T
V
A
E
N
F
G
V
K
M
P
E
Y
G
T
S
F
L
N
E
L
---
6
PsiBlast_PDB
98.05
43%
-111
- C6 -
3M8Z
4
DEOB_BACCR
B:
[10-395]
--
K
R
I
F
L
V
V
M
D
S
V
G
I
G
E
A
P
D
A
E
Q
F
G
D
L
G
S
D
T
I
G
H
I
A
E
H
M
----------
N
G
-
L
Q
M
P
N
M
V
K
L
G
L
G
N
I
R
E
M
K
G
I
S
K
V
E
K
P
L
G
Y
---------
Y
T
K
M
Q
E
K
S
T
G
K
D
T
M
T
G
H
W
E
I
M
G
L
Y
I
D
T
P
F
Q
V
F
P
E
---
G
F
P
K
E
L
L
D
E
L
E
E
K
T
G
R
K
-
I
I
G
N
K
P
A
S
G
T
E
I
L
D
E
L
G
Q
E
Q
M
E
T
G
S
L
I
V
Y
T
S
A
D
S
V
L
Q
I
A
A
H
E
E
V
V
P
L
D
E
L
Y
K
I
C
K
I
A
R
E
-
L
T
LD
E
-
K
Y
M
V
G
R
V
I
A
R
P
F
V
G
-
E
P
G
N
F
T
R
T
P
N
R
H
D
Y
A
L
K
P
F
G
R
T
V
M
N
E
-
L
K
D
S
D
Y
D
V
I
A
I
G
K
I
S
D
I
Y
D
G
E
G
V
T
E
S
L
R
T
K
S
N
M
D
G
M
D
K
L
V
D
T
L
-
N
M
D
F
T
G
L
S
F
L
N
L
V
D
F
D
A
L
F
G
H
R
R
D
P
Q
G
Y
G
E
A
L
Q
E
Y
D
A
R
L
P
E
V
F
A
K
L
K
E
D
D
L
L
L
I
T
A
D
H
G
N
D
P
I
H
P
G
T
D
H
T
R
E
Y
V
P
L
L
A
Y
S
P
S
M
K
--
E
G
G
QE
L
P
L
R
Q
T
F
A
D
I
G
A
T
V
A
E
N
F
G
V
K
M
P
E
Y
G
T
S
F
L
N
E
L
---
36
PsiBlast_CBE
97.84
43%
-112
- C6 -
4LRE
3
DEOB_BACCR
C:
[27-412]
--
K
R
I
F
L
V
V
M
D
S
V
G
I
G
E
A
P
D
A
E
Q
F
G
D
L
G
S
D
T
I
G
H
I
A
E
H
M
----------
N
G
-
L
Q
M
P
N
M
V
K
L
G
L
G
N
I
R
E
M
K
G
I
S
KV
E
K
P
L
G
Y
---------
Y
T
K
M
Q
E
K
S
T
G
K
D
T
M
T
G
H
W
E
I
M
G
L
Y
I
D
T
P
F
Q
V
F
P
E
---
G
F
P
K
E
L
L
D
E
L
E
E
K
T
G
R
K
-
I
I
G
N
K
P
A
S
G
T
E
I
L
D
E
L
G
Q
E
Q
M
E
T
G
S
L
I
V
Y
T
S
A
D
S
V
L
Q
I
A
A
H
E
E
V
V
P
L
D
E
L
Y
K
I
C
K
I
A
R
E
-
L
T
LD
E
-
K
Y
M
V
G
R
V
I
A
R
P
F
V
G
-
E
P
G
N
F
T
R
T
P
N
R
H
D
Y
A
L
K
P
F
G
R
T
V
M
N
E
-
L
K
D
S
D
Y
D
V
I
A
I
G
K
I
S
D
I
Y
D
G
E
G
V
T
E
S
L
R
T
K
S
N
M
D
G
M
D
K
L
V
D
T
L
-
N
M
D
F
T
G
L
S
F
L
N
L
V
D
F
D
A
L
F
G
H
R
R
D
P
Q
G
Y
G
E
A
L
Q
E
Y
D
A
R
L
P
E
V
F
A
K
L
K
E
D
D
L
L
L
I
T
A
D
H
G
N
D
P
I
H
P
G
T
D
H
T
R
E
Y
V
P
L
L
A
Y
S
P
S
M
K
--
E
G
G
QE
L
P
L
R
Q
T
F
A
D
I
G
A
T
V
A
E
N
F
G
V
K
M
P
E
Y
G
T
S
F
L
N
E
L
---
42
PsiBlast_CBE
97.48
43%
-111
- C6 -
3M8Z
3
DEOB_BACCR
C:
[10-395]
--
K
R
I
F
L
V
V
M
D
S
V
G
I
G
E
A
P
D
A
E
Q
F
G
D
L
G
S
D
T
I
G
H
I
A
E
H
M
----------
N
G
-
L
Q
M
P
N
M
V
K
L
G
L
G
N
I
R
E
M
K
G
I
S
KV
E
K
P
L
G
Y
---------
Y
T
K
M
Q
E
K
S
T
G
K
D
T
M
T
G
H
W
E
I
M
G
L
Y
I
D
T
P
F
Q
V
F
P
E
---
G
F
P
K
E
L
L
D
E
L
E
E
K
T
G
R
K
-
I
I
G
N
K
P
A
S
G
T
E
I
L
D
E
L
G
Q
E
Q
M
E
T
G
S
L
I
V
Y
T
S
A
D
S
V
L
Q
I
A
A
H
E
E
V
V
P
L
D
E
L
Y
K
I
C
K
I
A
R
E
-
L
T
LD
E
-
K
Y
M
V
G
R
V
I
A
R
P
F
V
G
-
E
P
G
N
F
T
R
T
P
N
R
H
D
Y
A
L
K
P
F
G
R
T
V
M
N
E
-
L
K
D
S
D
Y
D
V
I
A
I
G
K
I
S
D
I
Y
D
G
E
G
V
T
E
S
L
R
T
K
S
N
M
D
G
M
D
K
L
V
D
T
L
-
N
M
D
F
T
G
L
S
F
L
N
L
V
D
F
D
A
L
F
G
H
R
R
D
P
Q
G
Y
G
E
A
L
Q
E
Y
D
A
R
L
P
E
V
F
A
K
L
K
E
D
D
L
L
L
I
T
A
D
H
G
N
D
P
I
H
P
G
T
D
H
T
R
E
Y
V
P
L
L
A
Y
S
P
S
M
K
--
E
G
G
QE
L
P
L
R
Q
T
F
A
D
I
G
A
T
V
A
E
N
F
G
V
K
M
P
E
Y
G
T
S
F
L
N
E
L
---
41
PsiBlast_CBE
97.46
43%
-111
- C6 -
3OT9
3
DEOB_BACCR
B:
[10-395]
--
K
R
I
F
L
V
V
M
D
S
V
G
I
G
E
A
P
D
A
E
Q
F
G
D
L
G
S
D
T
I
G
H
I
A
E
H
M
----------
N
G
-
L
Q
M
P
N
M
V
K
L
G
L
G
N
I
R
E
M
K
G
I
S
K
V
E
K
P
L
G
Y
---------
Y
T
K
M
Q
E
K
S
T
G
K
D
T
M
T
G
H
W
E
I
M
G
L
Y
I
D
T
P
F
Q
V
F
P
E
---
G
F
P
K
E
L
L
D
E
L
E
E
K
T
G
R
K
-
I
I
G
N
K
P
A
S
G
T
E
I
L
D
E
L
G
Q
E
Q
M
E
T
G
S
L
I
V
Y
T
S
A
D
S
V
L
Q
I
A
A
H
E
E
V
V
P
L
D
E
L
Y
K
I
C
K
I
A
R
E
-
L
T
LD
E
-
K
Y
M
V
G
R
V
I
A
R
P
F
V
G
-
E
P
G
N
F
T
R
T
P
N
R
H
D
Y
A
L
K
P
F
G
R
T
V
M
N
E
-
L
K
D
S
D
Y
D
V
I
A
I
G
K
I
S
D
I
Y
D
G
E
G
V
T
E
S
L
R
T
K
S
N
M
D
G
M
D
K
L
V
D
T
L
-
N
M
D
F
T
G
L
S
F
L
N
L
V
D
F
D
A
L
F
G
H
R
R
D
P
Q
G
Y
G
E
A
L
Q
E
Y
D
A
R
L
P
E
V
F
A
K
L
K
E
D
D
L
L
L
I
T
A
D
H
G
N
D
P
I
H
P
G
T
D
H
T
R
E
Y
V
P
L
L
A
Y
S
P
S
M
K
--
E
G
G
QE
L
P
L
R
Q
T
F
A
D
I
G
A
T
V
A
E
N
F
G
V
K
M
P
E
Y
G
T
S
F
L
N
E
L
---
24
PsiBlast_CBE
97.44
43%
-111
- C6 -
3UN2
3
DEOB_BACCR
C:
[10-395]
--
K
R
I
F
L
V
V
M
D
S
V
G
I
G
E
A
P
D
A
E
Q
F
G
D
L
G
S
D
T
I
G
H
I
A
E
H
M
----------
N
G
-
L
Q
M
P
N
M
V
K
L
G
L
G
N
I
R
E
M
K
G
I
S
KV
E
K
P
L
G
Y
---------
Y
T
K
M
Q
E
K
S
T
G
K
D
Q
M
T
G
H
W
E
I
M
G
L
Y
I
D
T
P
F
Q
V
F
P
E
---
G
F
P
K
E
L
L
D
E
L
E
E
K
T
G
R
K
-
I
I
G
N
K
P
A
S
G
T
E
I
L
D
E
L
G
Q
E
Q
M
E
T
G
S
L
I
V
Y
T
S
A
D
S
V
L
Q
I
A
A
H
E
E
V
V
P
L
D
E
L
Y
K
I
C
K
I
A
R
E
-
L
T
LD
E
-
K
Y
M
V
G
R
V
I
A
R
P
F
V
G
-
E
P
G
N
F
T
R
T
P
N
R
H
D
Y
A
L
K
P
F
G
R
T
V
M
N
E
-
L
K
D
S
D
Y
D
V
I
A
I
G
K
I
S
D
I
Y
D
G
E
G
V
T
E
S
L
R
T
K
S
N
M
D
G
M
D
K
L
V
D
T
L
-
N
M
D
F
T
G
L
S
F
L
N
L
V
D
F
D
A
L
F
G
H
R
R
D
P
Q
G
Y
G
E
A
L
Q
E
Y
D
A
R
L
P
E
V
F
A
K
L
K
E
D
D
L
L
L
I
T
A
D
H
G
N
D
P
I
H
P
G
T
D
H
T
R
E
Y
V
P
L
L
A
Y
S
P
S
M
K
--
E
G
G
QE
L
P
L
R
Q
T
F
A
D
I
G
A
T
V
A
E
N
F
G
V
K
M
P
E
Y
G
T
S
F
L
N
E
L
---
22
PsiBlast_CBE
97.39
43%
-112
- C6 -
3UN3
4
DEOB_BACCR
C:
[10-395]
--
K
R
I
F
L
V
V
M
D
S
V
G
I
G
E
A
P
D
A
E
Q
F
G
D
L
G
S
D
T
I
G
H
I
A
E
H
M
----------
N
G
-
L
Q
M
P
N
M
V
K
L
G
L
G
N
I
R
E
M
K
G
I
S
KV
E
K
P
L
G
Y
---------
Y
T
K
M
Q
E
K
S
T
G
K
D
Q
M
T
G
H
W
E
I
M
G
L
Y
I
D
T
P
F
Q
V
F
P
E
---
G
F
P
K
E
L
L
D
E
L
E
E
K
T
G
R
K
-
I
I
G
N
K
P
A
S
G
T
E
I
L
D
E
L
G
Q
E
Q
M
E
T
G
S
L
I
V
Y
T
S
A
D
S
V
L
Q
I
A
A
H
E
E
V
V
P
L
D
E
L
Y
K
I
C
K
I
A
R
E
-
L
T
LD
E
-
K
Y
M
V
G
R
V
I
A
R
P
F
V
G
-
E
P
G
N
F
T
R
T
P
N
R
H
D
Y
A
L
K
P
F
G
R
T
V
M
N
E
-
L
K
D
S
D
Y
D
V
I
A
I
G
K
I
S
D
I
Y
D
G
E
G
V
T
E
S
L
R
T
K
S
N
M
D
G
M
D
K
L
V
D
T
L
-
N
M
D
F
T
G
L
S
F
L
N
L
V
D
F
D
A
L
F
G
H
R
R
D
P
Q
G
Y
G
E
A
L
Q
E
Y
D
A
R
L
P
E
V
F
A
K
L
K
E
D
D
L
L
L
I
T
A
D
H
G
N
D
P
I
H
P
G
T
D
H
T
R
E
Y
V
P
L
L
A
Y
S
P
S
M
K
--
E
G
G
QE
L
P
L
R
Q
T
F
A
D
I
G
A
T
V
A
E
N
F
G
V
K
M
P
E
Y
G
T
S
F
L
N
E
L
---
60
PsiBlast_CBE
97.38
43%
-112
- C6 -
4LRA
4
DEOB_BACCR
B:
[27-412]
--
K
R
I
F
L
V
V
M
D
S
V
G
I
G
E
A
P
D
A
E
Q
F
G
D
L
G
S
D
T
I
G
H
I
A
E
H
M
----------
N
G
-
L
Q
M
P
N
M
V
K
L
G
L
G
N
I
R
E
M
K
G
I
S
KV
E
K
P
L
G
Y
---------
Y
T
K
M
Q
E
K
S
T
G
K
D
T
M
T
G
H
W
E
I
M
G
L
Y
I
D
T
P
F
Q
V
F
P
E
---
G
F
P
K
E
L
L
D
E
L
E
E
K
T
G
R
K
-
I
I
G
N
K
P
A
S
G
T
E
I
L
D
E
L
G
Q
E
Q
M
E
T
G
S
L
I
V
Y
T
G
A
D
S
V
L
Q
I
A
A
H
E
E
V
V
P
L
D
E
L
Y
K
I
C
K
I
A
R
E
-
L
T
LD
E
-
K
Y
M
V
G
R
V
I
A
R
P
F
V
G
-
E
P
G
N
F
T
R
T
P
N
R
H
D
Y
A
L
K
P
F
G
R
T
V
M
N
E
-
L
K
D
S
D
Y
D
V
I
A
I
G
K
I
S
D
I
Y
D
G
E
G
V
T
E
S
L
R
T
K
S
N
M
D
G
M
D
K
L
V
D
T
L
-
N
M
D
F
T
G
L
S
F
L
N
L
V
D
F
D
A
L
F
G
H
R
R
D
P
Q
G
Y
G
E
A
L
Q
E
Y
D
A
R
L
P
E
V
F
A
K
L
K
E
D
D
L
L
L
I
T
A
D
H
G
N
D
P
I
H
P
G
T
D
H
T
R
E
Y
V
P
L
L
A
Y
S
P
S
M
K
--
E
G
G
QE
L
P
L
R
Q
T
F
A
D
I
G
A
T
V
A
E
N
F
G
V
K
M
P
E
Y
G
T
S
F
L
N
E
L
---
46
PsiBlast_CBE
97.38
43%
-112
- C6 -
3M8W
4
DEOB_BACCR
B:
[10-395]
--
K
R
I
F
L
V
V
M
D
S
V
G
I
G
E
A
P
D
A
E
Q
F
G
D
L
G
S
D
T
I
G
H
I
A
E
H
M
----------
N
G
-
L
Q
M
P
N
M
V
K
L
G
L
G
N
I
R
E
M
K
G
I
S
KV
E
K
P
L
G
Y
---------
Y
T
K
M
Q
E
K
S
T
G
K
D
T
M
T
G
H
W
E
I
M
G
L
Y
I
D
T
P
F
Q
V
F
P
E
---
G
F
P
K
E
L
L
D
E
L
E
E
K
T
G
R
K
-
I
I
G
N
K
P
A
S
G
T
E
I
L
D
E
L
G
Q
E
Q
M
E
T
G
S
L
I
V
Y
T
S
A
D
S
V
L
Q
I
A
A
H
E
E
V
V
P
L
D
E
L
Y
K
I
C
K
I
A
R
E
-
L
T
LD
E
-
K
Y
M
V
G
R
V
I
A
R
P
F
V
G
-
E
P
G
N
F
T
R
T
P
N
R
H
D
Y
A
L
K
P
F
G
R
T
V
M
N
E
-
L
K
D
S
D
Y
D
V
I
A
I
G
K
I
S
D
I
Y
D
G
E
G
V
T
E
S
L
R
T
K
S
N
M
D
G
M
D
K
L
V
D
T
L
-
N
M
D
F
T
G
L
S
F
L
N
L
V
D
F
D
A
L
F
G
H
R
R
D
P
Q
G
Y
G
E
A
L
Q
E
Y
D
A
R
L
P
E
V
F
A
K
L
K
E
D
D
L
L
L
I
T
A
D
H
G
N
D
P
I
H
P
G
T
D
H
T
R
E
Y
V
P
L
L
A
Y
S
P
S
M
K
--
E
G
G
QE
L
P
L
R
Q
T
F
A
D
I
G
A
T
V
A
E
N
F
G
V
K
M
P
E
Y
G
T
S
F
L
N
E
L
---
25
PsiBlast_CBE
97.38
43%
-112
- C6 -
3UN2
4
DEOB_BACCR
B:
[10-395]
--
K
R
I
F
L
V
V
M
D
S
V
G
I
G
E
A
P
D
A
E
Q
F
G
D
L
G
S
D
T
I
G
H
I
A
E
H
M
----------
N
G
-
L
Q
M
P
N
M
V
K
L
G
L
G
N
I
R
E
M
K
G
I
S
K
V
E
K
P
L
G
Y
---------
Y
T
K
M
Q
E
K
S
T
G
K
D
Q
M
T
G
H
W
E
I
M
G
L
Y
I
D
T
P
F
Q
V
F
P
E
---
G
F
P
K
E
L
L
D
E
L
E
E
K
T
G
R
K
-
I
I
G
N
K
P
A
S
G
T
E
I
L
D
E
L
G
Q
E
Q
M
E
T
G
S
L
I
V
Y
T
S
A
D
S
V
L
Q
I
A
A
H
E
E
V
V
P
L
D
E
L
Y
K
I
C
K
I
A
R
E
-
L
T
LD
E
-
K
Y
M
V
G
R
V
I
A
R
P
F
V
G
-
E
P
G
N
F
T
R
T
P
N
R
H
D
Y
A
L
K
P
F
G
R
T
V
M
N
E
-
L
K
D
S
D
Y
D
V
I
A
I
G
K
I
S
D
I
Y
D
G
E
G
V
T
E
S
L
R
T
K
S
N
M
D
G
M
D
K
L
V
D
T
L
-
N
M
D
F
T
G
L
S
F
L
N
L
V
D
F
D
A
L
F
G
H
R
R
D
P
Q
G
Y
G
E
A
L
Q
E
Y
D
A
R
L
P
E
V
F
A
K
L
K
E
D
D
L
L
L
I
T
A
D
H
G
N
D
P
I
H
P
G
T
D
H
T
R
E
Y
V
P
L
L
A
Y
S
P
S
M
K
--
E
G
G
QE
L
P
L
R
Q
T
F
A
D
I
G
A
T
V
A
E
N
F
G
V
K
M
P
E
Y
G
T
S
F
L
N
E
L
---
23
PsiBlast_CBE
97.38
43%
-113
- C6 -
3UN3
6
DEOB_BACCR
B:
[10-395]
--
K
R
I
F
L
V
V
M
D
S
V
G
I
G
E
A
P
D
A
E
Q
F
G
D
L
G
S
D
T
I
G
H
I
A
E
H
M
----------
N
G
-
L
Q
M
P
N
M
V
K
L
G
L
G
N
I
R
E
M
K
G
I
S
K
V
E
K
P
L
G
Y
---------
Y
T
K
M
Q
E
K
S
T
G
K
D
Q
M
T
G
H
W
E
I
M
G
L
Y
I
D
T
P
F
Q
V
F
P
E
---
G
F
P
K
E
L
L
D
E
L
E
E
K
T
G
R
K
-
I
I
G
N
K
P
A
S
G
T
E
I
L
D
E
L
G
Q
E
Q
M
E
T
G
S
L
I
V
Y
T
S
A
D
S
V
L
Q
I
A
A
H
E
E
V
V
P
L
D
E
L
Y
K
I
C
K
I
A
R
E
-
L
T
LD
E
-
K
Y
M
V
G
R
V
I
A
R
P
F
V
G
-
E
P
G
N
F
T
R
T
P
N
R
H
D
Y
A
L
K
P
F
G
R
T
V
M
N
E
-
L
K
D
S
D
Y
D
V
I
A
I
G
K
I
S
D
I
Y
D
G
E
G
V
T
E
S
L
R
T
K
S
N
M
D
G
M
D
K
L
V
D
T
L
-
N
M
D
F
T
G
L
S
F
L
N
L
V
D
F
D
A
L
F
G
H
R
R
D
P
Q
G
Y
G
E
A
L
Q
E
Y
D
A
R
L
P
E
V
F
A
K
L
K
E
D
D
L
L
L
I
T
A
D
H
G
N
D
P
I
H
P
G
T
D
H
T
R
E
Y
V
P
L
L
A
Y
S
P
S
M
K
--
E
G
G
QE
L
P
L
R
Q
T
F
A
D
I
G
A
T
V
A
E
N
F
G
V
K
M
P
E
Y
G
T
S
F
L
N
E
L
---
8
PsiBlast_PDB
97.32
43%
-112
- C6 -
3UO0
5
DEOB_BACCR
A:
[10-395]
--
K
R
I
F
L
V
V
M
D
S
V
G
I
G
E
A
P
D
A
E
Q
F
G
D
L
G
S
D
T
I
G
H
I
A
E
H
M
----------
N
G
-
L
Q
M
P
N
M
V
K
L
G
L
G
N
I
R
E
M
K
G
I
S
K
V
E
K
P
L
G
Y
---------
Y
T
K
M
Q
E
K
S
T
G
K
D
T
M
T
G
H
W
E
I
M
G
L
Y
I
D
T
P
F
Q
V
F
P
E
---
G
F
P
K
E
L
L
D
E
L
E
E
K
T
G
R
K
-
I
I
G
N
K
P
A
S
G
T
E
I
L
D
E
L
G
Q
E
Q
M
E
T
G
S
L
I
V
Y
T
S
A
D
S
V
L
Q
I
A
A
H
E
E
V
V
P
L
D
E
L
Y
K
I
C
K
I
A
R
E
-
L
T
LD
E
-
K
Y
M
V
G
R
V
I
A
R
P
F
V
G
-
E
P
G
N
F
T
R
T
P
N
R
H
D
Y
A
L
K
P
F
G
R
T
V
M
N
E
-
L
K
D
S
D
Y
D
V
I
A
I
G
K
I
S
D
I
Y
D
G
E
G
V
T
E
S
L
R
T
K
S
N
M
D
G
M
D
K
L
V
D
T
L
-
N
M
D
F
T
G
L
S
F
L
N
L
V
D
F
D
A
L
F
G
H
R
R
D
P
Q
G
Y
G
E
A
L
Q
E
Y
D
A
R
L
P
E
V
F
A
K
L
K
E
D
D
L
L
L
I
T
A
D
H
G
N
D
P
I
H
P
G
T
D
H
T
R
E
Y
V
P
L
L
A
Y
S
P
S
M
K
--
E
G
G
Q
E
L
P
L
R
Q
T
F
A
D
I
G
A
T
V
A
E
N
F
G
V
K
M
P
E
Y
G
T
S
F
L
N
E
L
---
13
PsiBlast_PDB
97.31
43%
-113
- C6 -
4LRD
6
DEOB_BACCR
A:
[27-412]
--
K
R
I
F
L
V
V
M
D
S
V
G
I
G
E
A
P
D
A
E
Q
F
G
D
L
G
S
D
T
I
G
H
I
A
E
H
M
----------
N
G
-
L
Q
M
P
N
M
V
K
L
G
L
G
N
I
R
E
M
K
G
I
S
K
V
E
K
P
L
G
Y
---------
Y
T
K
M
Q
E
K
S
I
G
K
D
T
M
T
G
H
W
E
I
M
G
L
Y
I
D
T
P
F
Q
V
F
P
E
---
G
F
P
K
E
L
L
D
E
L
E
E
K
T
G
R
K
-
I
I
G
N
K
P
A
S
G
T
E
I
L
D
E
L
G
Q
E
Q
M
E
T
G
S
L
I
V
Y
T
S
A
D
S
L
L
Q
I
A
A
H
E
E
V
V
P
L
D
E
L
Y
K
I
C
K
I
A
R
E
-
L
T
LD
E
-
K
Y
K
V
G
R
V
I
A
R
P
F
V
G
-
E
P
G
N
F
T
R
T
P
N
R
H
D
Y
A
L
K
P
F
G
R
T
V
M
N
E
-
L
K
D
S
D
Y
D
V
I
A
I
G
K
I
S
D
I
Y
D
G
E
G
V
T
E
S
L
R
T
K
S
N
M
D
G
M
D
K
L
V
D
T
L
-
N
M
D
F
T
G
L
S
F
L
N
L
V
D
F
D
A
L
F
G
H
R
R
D
P
Q
G
Y
G
E
A
L
Q
E
Y
D
A
R
L
P
E
V
F
A
K
L
K
E
D
D
L
L
L
I
T
A
D
H
G
N
D
P
I
H
P
G
T
D
H
T
R
E
Y
V
P
L
L
A
Y
S
P
S
M
K
--
E
G
G
Q
E
L
P
L
R
Q
T
F
A
D
I
G
A
T
V
A
E
N
F
G
V
K
M
P
E
Y
G
T
S
F
L
N
E
L
---
52
PsiBlast_CBE
97.24
43%
-112
- C6 -
4LR7
6
DEOB_BACCR
B:
[27-412]
--
K
R
I
F
L
V
V
M
D
S
V
G
I
G
E
A
P
D
A
E
Q
F
G
D
L
G
S
D
T
I
G
H
I
A
E
H
M
----------
N
G
-
L
Q
M
P
N
M
V
K
L
G
L
G
N
I
R
E
M
K
G
I
S
K
V
E
K
P
L
G
Y
---------
Y
T
K
M
Q
E
K
S
T
G
K
D
T
M
T
G
H
W
E
I
M
G
L
Y
I
D
T
P
F
Q
V
F
P
E
---
G
F
P
K
E
L
L
D
E
L
E
E
K
T
G
R
K
-
I
I
G
N
K
P
A
S
G
T
E
I
L
D
E
L
G
Q
E
Q
M
E
T
G
S
L
I
V
Y
T
A
A
D
S
V
L
Q
I
A
A
H
E
E
V
V
P
L
D
E
L
Y
K
I
C
K
I
A
R
E
-
L
T
LD
E
-
K
Y
M
V
G
R
V
I
A
R
P
F
V
G
-
E
P
G
N
F
T
R
T
P
N
R
H
D
Y
A
L
K
P
F
G
R
T
V
M
N
E
-
L
K
D
S
D
Y
D
V
I
A
I
G
K
I
S
D
I
Y
D
G
E
G
V
T
E
S
L
R
T
K
S
N
M
D
G
M
D
K
L
V
D
T
L
-
N
M
D
F
T
G
L
S
F
L
N
L
V
D
F
D
A
L
F
G
H
R
R
D
P
Q
G
Y
G
E
A
L
Q
E
Y
D
A
R
L
P
E
V
F
A
K
L
K
E
D
D
L
L
L
I
T
A
D
H
G
N
D
P
I
H
P
G
T
D
H
T
R
E
Y
V
P
L
L
A
Y
S
P
S
M
K
--
E
G
G
QE
L
P
L
R
Q
T
F
A
D
I
G
A
T
V
A
E
N
F
G
V
K
M
P
E
Y
G
T
S
F
L
N
E
L
---
7
PsiBlast_PDB
97.22
43%
-112
- C6 -
3TWZ
2
DEOB_BACCR
A:
[10-395]
--
K
R
I
F
L
V
V
M
D
S
V
G
I
G
E
A
P
D
A
E
Q
F
G
D
L
G
S
D
T
I
G
H
I
A
E
H
M
----------
N
G
-
L
Q
M
P
N
M
V
K
L
G
L
G
N
I
R
E
M
K
G
I
S
K
V
E
K
P
L
G
Y
---------
Y
T
K
M
Q
E
K
S
T
G
K
D
T
M
T
G
H
W
E
I
M
G
L
Y
I
D
T
P
F
Q
V
F
P
E
---
G
F
P
K
E
L
L
D
E
L
E
E
K
T
G
R
K
-
I
I
G
N
K
P
A
S
G
T
E
I
L
D
E
L
G
Q
E
Q
M
E
T
G
S
L
I
V
Y
T
S
A
D
S
V
L
Q
I
A
A
H
E
E
V
V
P
L
D
E
L
Y
K
I
C
K
I
A
R
E
-
L
T
LD
E
-
K
Y
M
V
G
R
V
I
A
R
P
F
V
G
-
E
P
G
N
F
T
R
T
P
N
R
H
D
Y
A
L
K
P
F
G
R
T
V
M
N
E
-
L
K
D
S
D
Y
D
V
I
A
I
G
K
I
S
D
I
Y
D
G
E
G
V
T
E
S
L
R
T
K
S
N
M
D
G
M
D
K
L
V
D
T
L
-
N
M
D
F
T
G
L
S
F
L
N
L
V
D
F
D
A
L
F
G
H
R
R
D
P
Q
G
Y
G
E
A
L
Q
E
Y
D
A
R
L
P
E
V
F
A
K
L
K
E
D
D
L
L
L
I
T
A
D
H
G
N
D
P
I
H
P
G
T
D
H
T
R
E
Y
V
P
L
L
A
Y
S
P
S
M
K
--
E
G
G
QE
L
P
L
R
Q
T
F
A
D
I
G
A
T
V
A
E
N
F
G
V
K
M
P
E
Y
G
T
S
F
L
N
E
L
K
--
47
PsiBlast_CBE
97.21
43%
-111
- C6 -
4LR9
3
DEOB_BACCR
C:
[27-412]
--
K
R
I
F
L
V
V
M
D
S
V
G
I
G
E
A
P
D
A
E
Q
F
G
D
L
G
S
D
T
I
G
H
I
A
E
H
M
----------
N
G
-
L
Q
M
P
N
M
V
K
L
G
L
G
N
I
R
E
M
K
G
I
S
KV
E
K
P
L
G
Y
---------
Y
T
K
M
Q
E
K
S
T
G
K
D
T
M
T
G
H
W
E
I
M
G
L
Y
I
D
T
P
F
Q
V
F
P
E
---
G
F
P
K
E
L
L
D
E
L
E
E
K
T
G
R
K
-
I
I
G
N
K
P
A
S
G
T
E
I
L
D
E
L
G
Q
E
Q
M
E
T
G
S
L
I
V
Y
T
A
A
D
S
V
L
Q
I
A
A
H
E
E
V
V
P
L
D
E
L
Y
K
I
C
K
I
A
R
E
-
L
T
LD
E
-
K
Y
M
V
G
R
V
I
A
R
P
F
V
G
-
E
P
G
N
F
T
R
T
P
N
R
H
D
Y
A
L
K
P
F
G
R
T
V
M
N
E
-
L
K
D
S
D
Y
D
V
I
A
I
G
K
I
S
D
I
Y
D
G
E
G
V
T
E
S
L
R
T
K
S
N
M
D
G
M
D
K
L
V
D
T
L
-
N
M
D
F
T
G
L
S
F
L
N
L
V
D
F
D
A
L
F
G
H
R
R
D
P
Q
G
Y
G
E
A
L
Q
E
Y
D
A
R
L
P
E
V
F
A
K
L
K
E
D
D
L
L
L
I
T
A
D
H
G
N
D
P
I
H
P
G
T
D
H
T
R
E
Y
V
P
L
L
A
Y
S
P
S
M
K
--
E
G
G
QE
L
P
L
R
Q
T
F
A
D
I
G
A
T
V
A
E
N
F
G
V
K
M
P
E
Y
G
T
S
F
L
N
E
L
---
59
PsiBlast_CBE
97.19
43%
-111
- C6 -
4LRA
3
DEOB_BACCR
C:
[27-412]
--
K
R
I
F
L
V
V
M
D
S
V
G
I
G
E
A
P
D
A
E
Q
F
G
D
L
G
S
D
T
I
G
H
I
A
E
H
M
----------
N
G
-
L
Q
M
P
N
M
V
K
L
G
L
G
N
I
R
E
M
K
G
I
S
KV
E
K
P
L
G
Y
---------
Y
T
K
M
Q
E
K
S
T
G
K
D
T
M
T
G
H
W
E
I
M
G
L
Y
I
D
T
P
F
Q
V
F
P
E
---
G
F
P
K
E
L
L
D
E
L
E
E
K
T
G
R
K
-
I
I
G
N
K
P
A
S
G
T
E
I
L
D
E
L
G
Q
E
Q
M
E
T
G
S
L
I
V
Y
T
G
A
D
S
V
L
Q
I
A
A
H
E
E
V
V
P
L
D
E
L
Y
K
I
C
K
I
A
R
E
-
L
T
LD
E
-
K
Y
M
V
G
R
V
I
A
R
P
F
V
G
-
E
P
G
N
F
T
R
T
P
N
R
H
D
Y
A
L
K
P
F
G
R
T
V
M
N
E
-
L
K
D
S
D
Y
D
V
I
A
I
G
K
I
S
D
I
Y
D
G
E
G
V
T
E
S
L
R
T
K
S
N
M
D
G
M
D
K
L
V
D
T
L
-
N
M
D
F
T
G
L
S
F
L
N
L
V
D
F
D
A
L
F
G
H
R
R
D
P
Q
G
Y
G
E
A
L
Q
E
Y
D
A
R
L
P
E
V
F
A
K
L
K
E
D
D
L
L
L
I
T
A
D
H
G
N
D
P
I
H
P
G
T
D
H
T
R
E
Y
V
P
L
L
A
Y
S
P
S
M
K
--
E
G
G
QE
L
P
L
R
Q
T
F
A
D
I
G
A
T
V
A
E
N
F
G
V
K
M
P
E
Y
G
T
S
F
L
N
E
L
---
21
PsiBlast_CBE
97.19
43%
-110
- C6 -
3M8Z
7
DEOB_BACCR
A:
[10-395]
--
K
R
I
F
L
V
V
M
D
S
V
G
I
G
E
A
P
D
A
E
Q
F
G
D
L
G
S
D
T
I
G
H
I
A
E
H
M
----------
N
G
-
L
Q
M
P
N
M
V
K
L
G
L
G
N
I
R
E
M
K
G
I
S
K
V
E
K
P
L
G
Y
---------
Y
T
K
M
Q
E
K
S
T
G
K
D
T
M
T
G
H
W
E
I
M
G
L
Y
I
D
T
P
F
Q
V
F
P
E
---
G
F
P
K
E
L
L
D
E
L
E
E
K
T
G
R
K
-
I
I
G
N
K
P
A
S
G
T
E
I
L
D
E
L
G
Q
E
Q
M
E
T
G
S
L
I
V
Y
T
S
A
D
S
V
L
Q
I
A
A
H
E
E
V
V
P
L
D
E
L
Y
K
I
C
K
I
A
R
E
-
L
T
LD
E
-
K
Y
M
V
G
R
V
I
A
R
P
F
V
G
-
E
P
G
N
F
T
R
T
P
N
R
H
D
Y
A
L
K
P
F
G
R
T
V
M
N
E
-
L
K
D
S
D
Y
D
V
I
A
I
G
K
I
S
D
I
Y
D
G
E
G
V
T
E
S
L
R
T
K
S
N
M
D
G
M
D
K
L
V
D
T
L
-
N
M
D
F
T
G
L
S
F
L
N
L
V
D
F
D
A
L
F
G
H
R
R
D
P
Q
G
Y
G
E
A
L
Q
E
Y
D
A
R
L
P
E
V
F
A
K
L
K
E
D
D
L
L
L
I
T
A
D
H
G
N
D
P
I
H
P
G
T
D
H
T
R
E
Y
V
P
L
L
A
Y
S
P
S
M
K
--
E
G
G
Q
E
L
P
L
R
Q
T
F
A
D
I
G
A
T
V
A
E
N
F
G
V
K
M
P
E
Y
G
T
S
F
L
N
E
L
---
50
PsiBlast_CBE
97.18
43%
-112
- C6 -
4LR8
4
DEOB_BACCR
B:
[27-412]
--
K
R
I
F
L
V
V
M
D
S
V
G
I
G
E
A
P
D
A
E
Q
F
G
D
L
G
S
D
T
I
G
H
I
A
E
H
M
----------
N
G
-
L
Q
M
P
N
M
V
K
L
G
L
G
N
I
R
E
M
K
G
I
S
K
V
E
K
P
L
G
Y
---------
Y
T
K
M
Q
E
K
S
T
G
K
D
T
M
T
G
H
W
E
I
M
G
L
Y
I
D
T
P
F
Q
V
F
P
E
---
G
F
P
K
E
L
L
D
E
L
E
E
K
T
G
R
K
-
I
I
G
N
K
P
A
S
G
T
E
I
L
D
E
L
G
Q
E
Q
M
E
T
G
S
L
I
V
Y
T
A
A
D
S
V
L
Q
I
A
A
H
E
E
V
V
P
L
D
E
L
Y
K
I
C
K
I
A
R
E
-
L
T
LD
E
-
K
Y
M
V
G
R
V
I
A
R
P
F
V
G
-
E
P
G
N
F
T
R
T
P
N
R
H
D
Y
A
L
K
P
F
G
R
T
V
M
N
E
-
L
K
D
S
D
Y
D
V
I
A
I
G
K
I
S
D
I
Y
D
G
E
G
V
T
E
S
L
R
T
K
S
N
M
D
G
M
D
K
L
V
D
T
L
-
N
M
D
F
T
G
L
S
F
L
N
L
V
D
F
D
A
L
F
G
H
R
R
D
P
Q
G
Y
G
E
A
L
Q
E
Y
D
A
R
L
P
E
V
F
A
K
L
K
E
D
D
L
L
L
I
T
A
D
H
G
N
D
P
I
H
P
G
T
D
H
T
R
E
Y
V
P
L
L
A
Y
S
P
S
M
K
--
E
G
G
QE
L
P
L
R
Q
T
F
A
D
I
G
A
T
V
A
E
N
F
G
V
K
M
P
E
Y
G
T
S
F
L
N
E
L
---
38
PsiBlast_CBE
97.12
43%
-114
- C6 -
3UO0
3
DEOB_BACCR
C:
[10-395]
--
K
R
I
F
L
V
V
M
D
S
V
G
I
G
E
A
P
D
A
E
Q
F
G
D
L
G
S
D
T
I
G
H
I
A
E
H
M
----------
N
G
-
L
Q
M
P
N
M
V
K
L
G
L
G
N
I
R
E
M
K
G
I
S
KV
E
K
P
L
G
Y
---------
Y
T
K
M
Q
E
K
S
T
G
K
D
T
M
T
G
H
W
E
I
M
G
L
Y
I
D
T
P
F
Q
V
F
P
E
---
G
F
P
K
E
L
L
D
E
L
E
E
K
T
G
R
K
-
I
I
G
N
K
P
A
S
G
T
E
I
L
D
E
L
G
Q
E
Q
M
E
T
G
S
L
I
V
Y
T
S
A
D
S
V
L
Q
I
A
A
H
E
E
V
V
P
L
D
E
L
Y
K
I
C
K
I
A
R
E
-
L
T
LD
E
-
K
Y
M
V
G
R
V
I
A
R
P
F
V
G
-
E
P
G
N
F
T
R
T
P
N
R
H
D
Y
A
L
K
P
F
G
R
T
V
M
N
E
-
L
K
D
S
D
Y
D
V
I
A
I
G
K
I
S
D
I
Y
D
G
E
G
V
T
E
S
L
R
T
K
S
N
M
D
G
M
D
K
L
V
D
T
L
-
N
M
D
F
T
G
L
S
F
L
N
L
V
D
F
D
A
L
F
G
H
R
R
D
P
Q
G
Y
G
E
A
L
Q
E
Y
D
A
R
L
P
E
V
F
A
K
L
K
E
D
D
L
L
L
I
T
A
D
H
G
N
D
P
I
H
P
G
T
D
H
T
R
E
Y
V
P
L
L
A
Y
S
P
S
M
K
--
E
G
G
QE
L
P
L
R
Q
T
F
A
D
I
G
A
T
V
A
E
N
F
G
V
K
M
P
E
Y
G
T
S
F
L
N
E
L
---
16
PsiBlast_PDB
96.90
43%
-111
- C6 -
4LR9
5
DEOB_BACCR
A:
[27-412]
--
K
R
I
F
L
V
V
M
D
S
V
G
I
G
E
A
P
D
A
E
Q
F
G
D
L
G
S
D
T
I
G
H
I
A
E
H
M
----------
N
G
-
L
Q
M
P
N
M
V
K
L
G
L
G
N
I
R
E
M
K
G
I
S
K
V
E
K
P
L
G
Y
---------
Y
T
K
M
Q
E
K
S
T
G
K
D
T
M
T
G
H
W
E
I
M
G
L
Y
I
D
T
P
F
Q
V
F
P
E
---
G
F
P
K
E
L
L
D
E
L
E
E
K
T
G
R
K
-
I
I
G
N
K
P
A
S
G
T
E
I
L
D
E
L
G
Q
E
Q
M
E
T
G
S
L
I
V
Y
T
A
A
D
S
V
L
Q
I
A
A
H
E
E
V
V
P
L
D
E
L
Y
K
I
C
K
I
A
R
E
-
L
T
LD
E
-
K
Y
M
V
G
R
V
I
A
R
P
F
V
G
-
E
P
G
N
F
T
R
T
P
N
R
H
D
Y
A
L
K
P
F
G
R
T
V
M
N
E
-
L
K
D
S
D
Y
D
V
I
A
I
G
K
I
S
D
I
Y
D
G
E
G
V
T
E
S
L
R
T
K
S
N
M
D
G
M
D
K
L
V
D
T
L
-
N
M
D
F
T
G
L
S
F
L
N
L
V
D
F
D
A
L
F
G
H
R
R
D
P
Q
G
Y
G
E
A
L
Q
E
Y
D
A
R
L
P
E
V
F
A
K
L
K
E
D
D
L
L
L
I
T
A
D
H
G
N
D
P
I
H
P
G
T
D
H
T
R
E
Y
V
P
L
L
A
Y
S
P
S
M
K
--
E
G
G
QE
L
P
L
R
Q
T
F
A
D
I
G
A
T
V
A
E
N
F
G
V
K
M
P
E
Y
G
T
S
F
L
N
E
L
---
20
PsiBlast_PDB
96.81
43%
-110
- C6 -
4LRF
7
DEOB_BACCR
A:
[27-412]
--
K
R
I
F
L
V
V
M
D
S
V
G
I
G
E
A
P
D
A
E
Q
F
G
D
L
G
S
D
T
I
G
H
I
A
E
H
M
----------
N
G
-
L
Q
M
P
N
M
V
K
L
G
L
G
N
I
R
E
M
K
G
I
S
K
V
E
K
P
L
G
Y
---------
Y
T
K
M
Q
E
K
S
T
G
K
D
T
M
T
G
H
W
E
I
M
G
L
Y
I
D
T
P
F
Q
V
F
P
E
---
G
F
P
K
E
L
L
D
E
L
E
E
K
T
G
R
K
-
I
I
G
N
K
P
A
S
G
T
E
I
L
D
E
L
G
Q
E
Q
M
E
T
G
S
L
I
V
Y
T
G
A
D
S
V
L
Q
I
A
A
H
E
E
V
V
P
L
D
E
L
Y
K
I
C
K
I
A
R
E
-
L
T
LD
E
-
K
Y
M
V
G
R
V
I
A
R
P
F
V
G
-
E
P
G
N
F
T
R
T
P
N
R
H
D
Y
A
L
K
P
F
G
R
T
V
M
N
E
-
L
K
D
S
D
Y
D
V
I
A
I
G
K
I
S
D
I
Y
D
G
E
G
V
T
E
S
L
R
T
K
S
N
M
D
G
M
D
K
L
V
D
T
L
-
N
M
D
F
T
G
L
S
F
L
N
L
V
D
F
D
A
L
F
G
H
R
R
D
P
Q
G
Y
G
E
A
L
Q
E
Y
D
A
R
L
P
E
V
F
A
K
L
K
E
D
D
L
L
L
I
T
A
D
H
G
N
D
P
I
H
P
G
T
D
H
T
R
E
Y
V
P
L
L
A
Y
S
P
S
M
K
--
E
G
G
QE
L
P
L
R
Q
T
F
A
D
I
G
A
T
V
A
E
N
F
G
V
K
M
P
E
Y
G
T
S
F
L
N
E
L
---
10
PsiBlast_PDB
96.80
43%
-110
- C6 -
3UN3
5
DEOB_BACCR
A:
[10-395]
--
K
R
I
F
L
V
V
M
D
S
V
G
I
G
E
A
P
D
A
E
Q
F
G
D
L
G
S
D
T
I
G
H
I
A
E
H
M
----------
N
G
-
L
Q
M
P
N
M
V
K
L
G
L
G
N
I
R
E
M
K
G
I
S
K
V
E
K
P
L
G
Y
---------
Y
T
K
M
Q
E
K
S
T
G
K
D
Q
M
T
G
H
W
E
I
M
G
L
Y
I
D
T
P
F
Q
V
F
P
E
---
G
F
P
K
E
L
L
D
E
L
E
E
K
T
G
R
K
-
I
I
G
N
K
P
A
S
G
T
E
I
L
D
E
L
G
Q
E
Q
M
E
T
G
S
L
I
V
Y
T
S
A
D
S
V
L
Q
I
A
A
H
E
E
V
V
P
L
D
E
L
Y
K
I
C
K
I
A
R
E
-
L
T
LD
E
-
K
Y
M
V
G
R
V
I
A
R
P
F
V
G
-
E
P
G
N
F
T
R
T
P
N
R
H
D
Y
A
L
K
P
F
G
R
T
V
M
N
E
-
L
K
D
S
D
Y
D
V
I
A
I
G
K
I
S
D
I
Y
D
G
E
G
V
T
E
S
L
R
T
K
S
N
M
D
G
M
D
K
L
V
D
T
L
-
N
M
D
F
T
G
L
S
F
L
N
L
V
D
F
D
A
L
F
G
H
R
R
D
P
Q
G
Y
G
E
A
L
Q
E
Y
D
A
R
L
P
E
V
F
A
K
L
K
E
D
D
L
L
L
I
T
A
D
H
G
N
D
P
I
H
P
G
T
D
H
T
R
E
Y
V
P
L
L
A
Y
S
P
S
M
K
--
E
G
G
Q
E
L
P
L
R
Q
T
F
A
D
I
G
A
T
V
A
E
N
F
G
V
K
M
P
E
Y
G
T
S
F
L
N
E
L
---
5
PsiBlast_PDB
96.66
43%
-111
- C6 -
3OT9
6
DEOB_BACCR
A:
[10-395]
--
K
R
I
F
L
V
V
M
D
S
V
G
I
G
E
A
P
D
A
E
Q
F
G
D
L
G
S
D
T
I
G
H
I
A
E
H
M
----------
N
G
-
L
Q
M
P
N
M
V
K
L
G
L
G
N
I
R
E
M
K
G
I
S
K
V
E
K
P
L
G
Y
---------
Y
T
K
M
Q
E
K
S
T
G
K
D
T
M
T
G
H
W
E
I
M
G
L
Y
I
D
T
P
F
Q
V
F
P
E
---
G
F
P
K
E
L
L
D
E
L
E
E
K
T
G
R
K
-
I
I
G
N
K
P
A
S
G
T
E
I
L
D
E
L
G
Q
E
Q
M
E
T
G
S
L
I
V
Y
T
S
A
D
S
V
L
Q
I
A
A
H
E
E
V
V
P
L
D
E
L
Y
K
I
C
K
I
A
R
E
-
L
T
LD
E
-
K
Y
M
V
G
R
V
I
A
R
P
F
V
G
-
E
P
G
N
F
T
R
T
P
N
R
H
D
Y
A
L
K
P
F
G
R
T
V
M
N
E
-
L
K
D
S
D
Y
D
V
I
A
I
G
K
I
S
D
I
Y
D
G
E
G
V
T
E
S
L
R
T
K
S
N
M
D
G
M
D
K
L
V
D
T
L
-
N
M
D
F
T
G
L
S
F
L
N
L
V
D
F
D
A
L
F
G
H
R
R
D
P
Q
G
Y
G
E
A
L
Q
E
Y
D
A
R
L
P
E
V
F
A
K
L
K
E
D
D
L
L
L
I
T
A
D
H
G
N
D
P
I
H
P
G
T
D
H
T
R
E
Y
V
P
L
L
A
Y
S
P
S
M
K
--
E
G
G
QE
L
P
L
R
Q
T
F
A
D
I
G
A
T
V
A
E
N
F
G
V
K
M
P
E
Y
G
T
S
F
L
N
E
L
---
15
PsiBlast_PDB
96.55
43%
-110
- C6 -
4LR8
7
DEOB_BACCR
A:
[27-412]
--
K
R
I
F
L
V
V
M
D
S
V
G
I
G
E
A
P
D
A
E
Q
F
G
D
L
G
S
D
T
I
G
H
I
A
E
H
M
----------
N
G
-
L
Q
M
P
N
M
V
K
L
G
L
G
N
I
R
E
M
K
G
I
S
K
V
E
K
P
L
G
Y
---------
Y
T
K
M
Q
E
K
S
T
G
K
D
T
M
T
G
H
W
E
I
M
G
L
Y
I
D
T
P
F
Q
V
F
P
E
---
G
F
P
K
E
L
L
D
E
L
E
E
K
T
G
R
K
-
I
I
G
N
K
P
A
S
G
T
E
I
L
D
E
L
G
Q
E
Q
M
E
T
G
S
L
I
V
Y
T
A
A
D
S
V
L
Q
I
A
A
H
E
E
V
V
P
L
D
E
L
Y
K
I
C
K
I
A
R
E
-
L
T
LD
E
-
K
Y
M
V
G
R
V
I
A
R
P
F
V
G
-
E
P
G
N
F
T
R
T
P
N
R
H
D
Y
A
L
K
P
F
G
R
T
V
M
N
E
-
L
K
D
S
D
Y
D
V
I
A
I
G
K
I
S
D
I
Y
D
G
E
G
V
T
E
S
L
R
T
K
S
N
M
D
G
M
D
K
L
V
D
T
L
-
N
M
D
F
T
G
L
S
F
L
N
L
V
D
F
D
A
L
F
G
H
R
R
D
P
Q
G
Y
G
E
A
L
Q
E
Y
D
A
R
L
P
E
V
F
A
K
L
K
E
D
D
L
L
L
I
T
A
D
H
G
N
D
P
I
H
P
G
T
D
H
T
R
E
Y
V
P
L
L
A
Y
S
P
S
M
K
--
E
G
G
Q
E
L
P
L
R
Q
T
F
A
D
I
G
A
T
V
A
E
N
F
G
V
K
M
P
E
Y
G
T
S
F
L
N
E
L
---
19
PsiBlast_PDB
96.22
43%
-113
- C6 -
4LRB
6
DEOB_BACCR
A:
[27-412]
--
K
R
I
F
L
V
V
M
D
S
V
G
I
G
E
A
P
D
A
E
Q
F
G
D
L
G
S
D
T
I
G
H
I
A
E
H
M
----------
N
G
-
L
Q
M
P
N
M
V
K
L
G
L
G
N
I
R
E
M
K
G
I
S
K
V
E
K
P
L
G
Y
---------
Y
T
K
M
Q
E
K
S
T
G
K
D
T
M
T
G
H
W
E
I
M
G
L
Y
I
D
T
P
F
Q
V
F
P
E
---
G
F
P
K
E
L
L
D
E
L
E
E
K
T
G
R
K
-
I
I
G
N
K
P
A
S
G
T
E
I
L
D
E
L
G
Q
E
Q
M
E
T
G
S
L
I
V
Y
T
G
A
D
S
V
L
Q
I
A
A
H
E
E
V
V
P
L
D
E
L
Y
K
I
C
K
I
A
R
E
-
L
T
LD
E
-
K
Y
M
V
G
R
V
I
A
R
P
F
V
G
-
E
P
G
N
F
T
R
T
P
N
R
H
D
Y
A
L
K
P
F
G
R
T
V
M
N
E
-
L
K
D
S
D
Y
D
V
I
A
I
G
K
I
S
D
I
Y
D
G
E
G
V
T
E
S
L
R
T
K
S
N
M
D
G
M
D
K
L
V
D
T
L
-
N
M
D
F
T
G
L
S
F
L
N
L
V
D
F
D
A
L
F
G
H
R
R
D
P
Q
G
Y
G
E
A
L
Q
E
Y
D
A
R
L
P
E
V
F
A
K
L
K
E
D
D
L
L
L
I
T
A
D
H
G
N
D
P
I
H
P
G
T
D
H
T
R
E
Y
V
P
L
L
A
Y
S
P
S
M
K
--
E
G
G
QE
L
P
L
R
Q
T
F
A
D
I
G
A
T
V
A
E
N
F
G
V
K
M
P
E
Y
G
T
S
F
L
N
E
L
---
66
HHSearch
94.94
45%
-102
* C6 *
3OT9
6
DEOB_BACCR
A:
[9-397]
-
Y
K
R
I
F
L
V
V
M
D
S
V
G
I
G
E
A
P
D
A
E
Q
F
G
D
L
G
S
D
T
I
G
H
I
A
E
H
----------
M
N
G
-
L
Q
M
P
N
M
V
K
L
G
L
G
-
N
I
R
E
M
K
G
-----
I
S
--
K
V
-
E
K
P
L
G
Y
Y
T
K
M
Q
E
K
S
T
G
K
D
T
M
T
G
H
W
E
I
M
G
L
Y
I
D
T
P
F
Q
V
F
P
---
E
G
F
P
K
E
L
L
D
E
L
E
E
K
T
G
R
-
K
I
I
G
N
K
P
A
S
G
T
E
I
L
D
E
L
G
Q
E
Q
M
E
T
G
S
L
I
V
Y
T
S
A
D
S
V
L
Q
I
A
A
H
E
E
V
V
P
L
D
E
L
Y
K
I
C
K
I
A
R
E
L
T
L
--
D
E
K
Y
M
V
G
R
V
I
A
R
P
F
V
G
E
P
G
-
N
F
T
R
T
P
N
R
H
D
Y
A
L
K
P
F
G
R
T
V
M
N
E
L
K
-
D
S
D
Y
D
V
I
A
I
G
K
I
S
D
I
Y
D
G
E
G
V
T
E
S
L
R
T
K
S
N
M
D
G
M
D
K
L
V
D
T
L
N
M
-
D
F
T
G
L
S
F
L
N
L
V
D
F
D
A
L
F
G
H
R
R
D
P
Q
G
Y
G
E
A
L
Q
E
Y
D
A
R
L
P
E
V
F
A
K
L
K
E
D
D
L
L
L
I
T
A
D
H
G
N
D
P
I
H
P
G
T
D
H
T
R
E
Y
V
P
L
L
A
Y
S
P
S
M
K
EG
G
Q
E
--
L
P
L
R
Q
T
F
A
D
I
G
A
T
V
A
E
N
F
G
V
K
M
P
E
Y
G
T
S
F
L
N
E
L
---