@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_1114: (2015-12-21 )
MKTYNVAIVGASGAVGQELIKGLENSFFPIKKFVPLASARSAGKKIRAFNKDYEILETTHEVFEKEEIDIAFFSAGGSVSEEFAISASKTALVIDNTSFFRLNKDVPLVVPEINAQEIFNAPLNIIANPNCSTIQMTQILNPLHLHFKIKSVIVSTYQAVSGAGNKGIESLKNELKTALEHLEKDPAIDLNQVLQAGAFAYPIAFNAIAHIDTFKENGYTKEELKMVHETHKIMGVDFPISATCVRVPVLRSHSESLSIAFEKEFDLKEVYEVLKNAPSVVVCDDPSHNLYPTPLKASHTDSVFIGRLRKDLFDKKTLHGFCVADQLRVGAATNALKIALHYIKNA
Atome Classification :
(34 SA)
.........10........20........30........-40........-----50-------........60........70........80.....-...-90...-.....100.......110..-.....120-------.........130.......140.......150.......160.......170.......180.......190-........200.--------........210...--....--220.......230....---------.-..240.......250.......260.......270.......280....---..------.290...-.-..-.300.......310-...--.....320.......330.......340....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
K
T
Y
N
V
A
I
V
GASG
A
V
G
Q
E
L
I
K
G
L
ENSFF
P
I
K
K
F
VPLASA-RSAGK
K
I
R
AF-----NK-------
D
Y
E
I
L
E
T
T
H
E
V
F
E
KEEI
D
I
A
F
FSAGGSV
S
E
E
F
AIS-AS
K
-
T
A
L
V
I-DNT
S
F
F
R
LNKDV
P
L
V
VPEI
N
-
A
Q
E
I
F
N---------APL
N
I
IANPNCS
T
I
Q
M
T
QILN
P
L
H
L
H
F
K
I
K
S
V
I
V
S
T
Y
Q
A
VSGAGNK
G
I
E
S
L
K
N
E
L
K
T
A
L
E
H
LEKDPAI
D
L
-
N
-
Q
V
L
Q
AGA
F
A
--Y--------
P
I
A
F
N
A
I
A
H
I
D
T
F
K--ENGY--
T
K
E
E
L
K
M
V
H
E
T
H
K
I
M
GV---------D-FPIS
A
T
C
V
RV
P
V
LRSHSE
S
L
S
I
A
F
EKEF
D
L
K
E
V
Y
E
V
L
KNAP
S
V
V
V
CDDP---SH------NLYPTPL-K-AS-HTD
S
V
F
I
G
R
L
R
K
D
--
L
FD--KKTLH
G
F
C
V
A
D
Q
LRVGAA
T
N
A
L
K
I
A
L
H
Y
IKNA
32
PsiBlast_CBE
96.01
48%
-86
- C2 -
3PZB
5
?
B:
[3-338]
---
Y
T
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
P
I
D
K
I
R
Y
L
A
S
A
-
R
S
A
G
K
S
L
K
F
K
-----
D
Q
-------
D
I
T
I
E
E
T
T
E
T
A
F
E
G
--
V
D
I
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
-
A
V
K
-
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
P
E
V
N
-
A
H
A
L
-
D
---------
A
H
N
G
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
L
E
T
Q
R
E
L
R
E
V
L
N
D
G
V
K
--
P
C
D
L
-
H
A
E
I
L
P
S
G
G
D
K
KH
Y
--------
P
I
A
F
N
A
L
P
Q
I
D
V
F
T
--
D
N
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
---------
D
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
P
G
A
V
L
E
D
D
V
---
A
H
------
Q
I
Y
P
Q
A
I
-
N
-
A
V
-
G
S
R
D
T
F
V
G
R
I
R
K
D
--
L
D
A
--
E
K
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
T
L
H
E
R
G
21
PsiBlast_CBE
95.96
48%
-88
- C2 -
4R5H
6
?
B:
[3-338]
---
Y
T
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
P
I
D
K
I
R
Y
L
A
S
A
-
R
S
A
G
K
S
L
K
F
K
-----
D
Q
-------
D
I
T
I
E
E
T
T
E
T
A
F
E
G
--
V
D
I
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
-
A
V
K
-
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
P
E
V
N
-
A
H
A
L
-
D
---------
A
H
N
G
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
L
E
T
Q
R
E
L
R
E
V
L
N
D
G
V
K
--
P
C
D
L
-
H
A
E
I
L
P
S
G
G
D
K
KH
Y
--------
P
I
A
F
N
A
L
P
Q
I
D
V
F
T
--
D
N
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
---------
D
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
P
G
A
V
L
E
D
D
V
---
A
H
------
Q
I
Y
P
Q
A
I
-
N
-
A
V
-
G
S
R
D
T
F
V
G
R
I
R
K
D
--
L
D
A
--
E
K
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
T
L
H
E
R
G
23
PsiBlast_CBE
95.89
48%
-87
- C2 -
4R51
8
?
B:
[3-338]
---
Y
T
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
P
I
D
K
I
R
Y
L
A
S
A
-
R
S
A
G
K
S
L
K
F
K
-----
D
Q
-------
D
I
T
I
E
E
T
T
E
T
A
F
E
G
--
V
D
I
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
-
A
V
K
-
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
P
E
V
N
-
A
H
A
L
-
D
---------
A
H
N
G
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
L
E
T
Q
R
E
L
R
E
V
L
N
D
G
V
K
--
P
C
D
L
-
H
A
E
I
L
P
S
G
G
D
K
KH
Y
--------
P
I
A
F
N
A
L
P
Q
I
D
V
F
T
--
D
N
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
---------
D
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
P
G
A
V
L
E
D
D
V
---
A
H
------
Q
I
Y
P
Q
A
I
-
N
-
A
V
-
G
S
R
D
T
F
V
G
R
I
R
K
D
--
L
D
A
--
E
K
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
T
L
H
E
R
G
35
PsiBlast_CBE
95.79
48%
-86
- C2 -
3PYL
1
?
B:
[3-338]
---
Y
T
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
P
I
D
K
I
R
Y
L
A
S
A
-
R
S
A
G
K
S
L
K
F
K
-----
D
Q
-------
D
I
T
I
E
E
T
T
E
T
A
F
E
G
--
V
D
I
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
-
A
V
K
-
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
P
E
V
N
-
A
H
A
L
-
D
---------
A
H
N
G
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
L
E
T
Q
R
E
L
R
E
V
L
N
D
G
V
K
--
P
C
D
L
-
H
A
E
I
L
P
S
G
G
D
K
KH
Y
--------
P
I
A
F
N
A
L
P
Q
I
D
V
F
T
--
D
N
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
---------
D
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
P
G
A
V
L
E
D
D
V
---
A
H
------
Q
I
Y
P
Q
A
I
-
N
-
A
V
-
G
S
R
D
T
F
V
G
R
I
R
K
D
--
L
D
A
--
E
K
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
T
L
H
E
R
G
37
PsiBlast_CBE
95.71
48%
-86
- C2 -
3PWK
8
?
B:
[3-338]
---
Y
T
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
P
I
D
K
I
R
Y
L
A
S
A
-
R
S
A
G
K
S
L
K
F
K
-----
D
Q
-------
D
I
T
I
E
E
T
T
E
T
A
F
E
G
--
V
D
I
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
-
A
V
K
-
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
P
E
V
N
-
A
H
A
L
-
D
---------
A
H
N
G
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
L
E
T
Q
R
E
L
R
E
V
L
N
D
G
V
K
--
P
C
D
L
-
H
A
E
I
L
P
S
G
G
D
K
KH
Y
--------
P
I
A
F
N
A
L
P
Q
I
D
V
F
T
--
D
N
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
---------
D
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
P
G
A
V
L
E
D
D
V
---
A
H
------
Q
I
Y
P
Q
A
I
-
N
-
A
V
-
G
S
R
D
T
F
V
G
R
I
R
K
D
--
L
D
A
--
E
K
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
T
L
H
E
R
G
27
PsiBlast_CBE
95.69
48%
-85
- C2 -
4R3N
10
?
B:
[3-338]
---
Y
T
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
P
I
D
K
I
R
Y
L
A
S
A
-
R
S
A
G
K
S
L
K
F
K
-----
D
Q
-------
D
I
T
I
E
E
T
T
E
T
A
F
E
G
--
V
D
I
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
-
A
V
K
-
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
P
E
V
N
-
A
H
A
L
-
D
---------
A
H
N
G
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
L
E
T
Q
R
E
L
R
E
V
L
N
D
G
V
K
--
P
C
D
L
-
H
A
E
I
L
P
S
G
G
D
K
KH
Y
--------
P
I
A
F
N
A
L
P
Q
I
D
V
F
T
--
D
N
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
---------
D
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
P
G
A
V
L
E
D
D
V
---
A
H
------
Q
I
Y
P
Q
A
I
-
N
-
A
V
-
G
S
R
D
T
F
V
G
R
I
R
K
D
--
L
D
A
--
E
K
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
T
L
H
E
R
G
24
PsiBlast_CBE
95.49
48%
-86
- C2 -
4R4J
7
?
B:
[3-338]
---
Y
T
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
P
I
D
K
I
R
Y
L
A
S
A
-
R
S
A
G
K
S
L
K
F
K
-----
D
Q
-------
D
I
T
I
E
E
T
T
E
T
A
F
E
G
--
V
D
I
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
-
A
V
K
-
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
P
E
V
N
-
A
H
A
L
-
D
---------
A
H
N
G
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
L
E
T
Q
R
E
L
R
E
V
L
N
D
G
V
K
--
P
C
D
L
-
H
A
E
I
L
P
S
G
G
D
K
KH
Y
--------
P
I
A
F
N
A
L
P
Q
I
D
V
F
T
--
D
N
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
---------
D
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
P
G
A
V
L
E
D
D
V
---
A
H
------
Q
I
Y
P
Q
A
I
-
N
-
A
V
-
G
S
R
D
T
F
V
G
R
I
R
K
D
--
L
D
A
--
E
K
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
T
L
H
E
R
G
5
PsiBlast_PDB
95.47
48%
-86
- C2 -
3PWK
8
?
A:
[3-338]
---
Y
T
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
P
I
D
K
I
R
Y
L
A
S
A
-
R
S
A
G
K
S
L
K
F
K
-----
D
Q
-------
D
I
T
I
E
E
T
T
E
T
A
F
E
G
--
V
D
I
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
-
A
V
K
-
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
P
E
V
N
-
A
H
A
L
-
D
---------
A
H
N
G
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
L
E
T
Q
R
E
L
R
E
V
L
N
D
G
V
K
--
P
C
D
L
-
H
A
E
I
L
P
S
G
G
D
K
K
H
Y
--------
P
I
A
F
N
A
L
P
Q
I
D
V
F
T
--
D
N
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
---------
D
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
P
G
A
V
L
E
D
D
V
---
A
H
------
Q
I
Y
P
Q
A
I
-
N
-
A
V
-
G
S
R
D
T
F
V
G
R
I
R
K
D
--
L
D
A
--
E
K
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
T
L
H
E
R
G
7
PsiBlast_PDB
95.35
48%
-85
- C2 -
3PYL
1
?
A:
[3-338]
---
Y
T
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
P
I
D
K
I
R
Y
L
A
S
A
-
R
S
A
G
K
S
L
K
F
K
-----
D
Q
-------
D
I
T
I
E
E
T
T
E
T
A
F
E
G
--
V
D
I
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
-
A
V
K
-
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
P
E
V
N
-
A
H
A
L
-
D
---------
A
H
N
G
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
L
E
T
Q
R
E
L
R
E
V
L
N
D
G
V
K
--
P
C
D
L
-
H
A
E
I
L
P
S
G
G
D
K
K
H
Y
--------
P
I
A
F
N
A
L
P
Q
I
D
V
F
T
--
D
N
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
---------
D
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
P
G
A
V
L
E
D
D
V
---
A
H
------
Q
I
Y
P
Q
A
I
-
N
-
A
V
-
G
S
R
D
T
F
V
G
R
I
R
K
D
--
L
D
A
--
E
K
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
T
L
H
E
R
G
34
PsiBlast_CBE
94.94
48%
-87
- C2 -
3PYL
1
?
C:
[3-338]
---
Y
T
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
P
I
D
K
I
R
Y
L
A
S
A
-
R
S
A
G
K
S
L
K
F
K
-----
D
Q
-------
D
I
T
I
E
E
T
T
E
T
A
F
E
G
--
V
D
I
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
-
A
V
K
-
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
P
E
V
N
-
A
H
A
L
-
D
---------
A
H
N
G
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
L
E
T
Q
R
E
L
R
E
V
L
N
D
G
V
K
--
P
C
D
L
-
H
A
E
I
L
P
S
G
G
D
K
KH
Y
--------
P
I
A
F
N
A
L
P
Q
I
D
V
F
T
--
D
N
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
---------
D
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
P
G
A
V
L
E
D
D
V
---
A
H
------
Q
I
Y
P
Q
A
I
-
N
-
A
V
-
G
S
R
D
T
F
V
G
R
I
R
K
D
--
L
D
A
--
E
K
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
T
L
H
E
R
G
3
PsiBlast_PDB
94.84
48%
-87
- C2 -
2GZ2
1
?
A:
[3-338]
---
Y
T
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
P
I
D
K
I
R
Y
L
A
S
A
-
R
S
A
G
K
S
L
K
F
K
-----
D
Q
-------
D
I
T
I
E
E
T
T
E
T
A
F
E
G
--
V
D
I
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
-
A
V
K
-
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
P
E
V
N
-
A
H
A
L
-
D
---------
A
H
N
G
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
L
E
T
Q
R
E
L
R
E
V
L
N
D
G
V
K
--
P
C
D
L
-
H
A
E
I
L
P
S
G
G
D
K
K
H
Y
--------
P
I
A
F
N
A
L
P
Q
I
D
V
F
T
--
D
N
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
---------
D
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
P
G
A
V
L
E
D
D
V
---
A
H
------
Q
I
Y
P
Q
A
I
-
N
-
A
V
-
G
S
R
D
T
F
V
G
R
I
R
K
D
--
L
D
A
--
E
K
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
T
L
H
E
R
G
2
PsiBlast_PDB
94.77
48%
-85
- C2 -
2GZ1
1
?
A:
[3-338]
---
Y
T
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
P
I
D
K
I
R
Y
L
A
S
A
-
R
S
A
G
K
S
L
K
F
K
-----
D
Q
-------
D
I
T
I
E
E
T
T
E
T
A
F
E
G
--
V
D
I
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
-
A
V
K
-
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
P
E
V
N
-
A
H
A
L
-
D
---------
A
H
N
G
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
L
E
T
Q
R
E
L
R
E
V
L
N
D
G
V
K
--
P
C
D
L
-
H
A
E
I
L
P
S
G
G
D
K
K
H
Y
--------
P
I
A
F
N
A
L
P
Q
I
D
V
F
T
--
D
N
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
---------
D
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
P
G
A
V
L
E
D
D
V
---
A
H
------
Q
I
Y
P
Q
A
I
-
N
-
A
V
-
G
S
R
D
T
F
V
G
R
I
R
K
D
--
L
D
A
--
E
K
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
T
L
H
E
R
G
26
PsiBlast_CBE
94.70
48%
-87
- C2 -
4R3W
8
?
B:
[3-338]
---
Y
T
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
P
I
D
K
I
R
Y
L
A
S
A
-
R
S
A
G
K
S
L
K
F
K
-----
D
Q
-------
D
I
T
I
E
E
T
T
E
T
A
F
E
G
--
V
D
I
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
-
A
V
K
-
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
P
E
V
N
-
A
H
A
L
-
D
---------
A
H
N
G
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
L
E
T
Q
R
E
L
R
E
V
L
N
D
G
V
K
--
P
C
D
L
-
H
A
E
I
L
P
S
G
G
D
K
KH
Y
--------
P
I
A
F
N
A
L
P
Q
I
D
V
F
T
--
D
N
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
---------
D
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
P
G
A
V
L
E
D
D
V
---
A
H
------
Q
I
Y
P
Q
A
I
-
N
-
A
V
-
G
S
R
D
T
F
V
G
R
I
R
K
D
--
L
D
A
--
E
K
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
T
L
H
E
R
G
22
PsiBlast_CBE
94.66
48%
-85
- C2 -
4R54
4
?
B:
[3-338]
---
Y
T
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
P
I
D
K
I
R
Y
L
A
S
A
-
R
S
A
G
K
S
L
K
F
K
-----
D
Q
-------
D
I
T
I
E
E
T
T
E
T
A
F
E
G
--
V
D
I
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
-
A
V
K
-
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
P
E
V
N
-
A
H
A
L
-
D
---------
A
H
N
G
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
L
E
T
Q
R
E
L
R
E
V
L
N
D
G
V
K
--
P
C
D
L
-
H
A
E
I
L
P
S
G
G
D
K
KH
Y
--------
P
I
A
F
N
A
L
P
Q
I
D
V
F
T
--
D
N
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
---------
D
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
P
G
A
V
L
E
D
D
V
---
A
H
------
Q
I
Y
P
Q
A
I
-
N
-
A
V
-
G
S
R
D
T
F
V
G
R
I
R
K
D
--
L
D
A
--
E
K
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
T
L
H
E
R
G
31
PsiBlast_CBE
94.62
48%
-83
- C2 -
3Q11
5
?
B:
[3-338]
---
Y
T
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
P
I
D
K
I
R
Y
L
A
S
A
-
R
S
A
G
K
S
L
K
F
K
-----
D
Q
-------
D
I
T
I
E
E
T
T
E
T
A
F
E
G
--
V
D
I
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
-
A
V
K
-
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
P
E
V
N
-
A
H
A
L
-
D
---------
A
H
N
G
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
L
E
T
Q
R
E
L
R
E
V
L
N
D
G
V
K
--
P
C
D
L
-
H
A
E
I
L
P
S
G
G
D
K
KH
Y
--------
P
I
A
F
N
A
L
P
Q
I
D
V
F
T
--
D
N
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
---------
D
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
P
G
A
V
L
E
D
D
V
---
A
H
------
Q
I
Y
P
Q
A
I
-
N
-
A
V
-
G
S
R
D
T
F
V
G
R
I
R
K
D
--
L
D
A
--
E
K
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
T
L
H
E
R
G
13
PsiBlast_PDB
94.56
48%
-86
- C2 -
4R3W
8
?
A:
[3-338]
---
Y
T
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
P
I
D
K
I
R
Y
L
A
S
A
-
R
S
A
G
K
S
L
K
F
K
-----
D
Q
-------
D
I
T
I
E
E
T
T
E
T
A
F
E
G
--
V
D
I
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
-
A
V
K
-
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
P
E
V
N
-
A
H
A
L
-
D
---------
A
H
N
G
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
L
E
T
Q
R
E
L
R
E
V
L
N
D
G
V
K
--
P
C
D
L
-
H
A
E
I
L
P
S
G
G
D
K
K
H
Y
--------
P
I
A
F
N
A
L
P
Q
I
D
V
F
T
--
D
N
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
---------
D
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
P
G
A
V
L
E
D
D
V
---
A
H
------
Q
I
Y
P
Q
A
I
-
N
-
A
V
-
G
S
R
D
T
F
V
G
R
I
R
K
D
--
L
D
A
--
E
K
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
T
L
H
E
R
G
29
PsiBlast_CBE
94.53
48%
-86
- C2 -
3Q1L
1
?
C:
[3-338]
---
Y
T
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
P
I
D
K
I
R
Y
L
A
S
A
-
R
S
A
G
K
S
L
K
F
K
-----
D
Q
-------
D
I
T
I
E
E
T
T
E
T
A
F
E
G
--
V
D
I
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
-
A
V
K
-
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
P
E
V
N
-
A
H
A
L
-
D
---------
A
H
N
G
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
L
E
T
Q
R
E
L
R
E
V
L
N
D
G
V
K
--
P
C
D
L
-
H
A
E
I
L
P
S
G
G
D
K
KH
Y
--------
P
I
A
F
N
A
L
P
Q
I
D
V
F
T
--
D
N
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
---------
D
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
P
G
A
V
L
E
D
D
V
---
A
H
------
Q
I
Y
P
Q
A
I
-
N
-
A
V
-
G
S
R
D
T
F
V
G
R
I
R
K
D
--
L
D
A
--
E
K
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
T
L
H
E
R
G
14
PsiBlast_PDB
94.50
48%
-86
- C2 -
4R41
10
?
A:
[3-338]
---
Y
T
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
P
I
D
K
I
R
Y
L
A
S
A
-
R
S
A
G
K
S
L
K
F
K
-----
D
Q
-------
D
I
T
I
E
E
T
T
E
T
A
F
E
G
--
V
D
I
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
-
A
V
K
-
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
P
E
V
N
-
A
H
A
L
-
D
---------
A
H
N
G
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
L
E
T
Q
R
E
L
R
E
V
L
N
D
G
V
K
--
P
C
D
L
-
H
A
E
I
L
P
S
G
G
D
K
K
H
Y
--------
P
I
A
F
N
A
L
P
Q
I
D
V
F
T
--
D
N
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
---------
D
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
P
G
A
V
L
E
D
D
V
---
A
H
------
Q
I
Y
P
Q
A
I
-
N
-
A
V
-
G
S
R
D
T
F
V
G
R
I
R
K
D
--
L
D
A
--
E
K
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
T
L
H
E
R
G
6
PsiBlast_PDB
94.47
48%
-87
- C2 -
3PWS
3
?
A:
[3-338]
---
Y
T
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
P
I
D
K
I
R
Y
L
A
S
A
-
R
S
A
G
K
S
L
K
F
K
-----
D
Q
-------
D
I
T
I
E
E
T
T
E
T
A
F
E
G
--
V
D
I
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
-
A
V
K
-
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
P
E
V
N
-
A
H
A
L
-
D
---------
A
H
N
G
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
L
E
T
Q
R
E
L
R
E
V
L
N
D
G
V
K
--
P
C
D
L
-
H
A
E
I
L
P
S
G
G
D
K
K
H
Y
--------
P
I
A
F
N
A
L
P
Q
I
D
V
F
T
--
D
N
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
---------
D
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
P
G
A
V
L
E
D
D
V
---
A
H
------
Q
I
Y
P
Q
A
I
-
N
-
A
V
-
G
S
R
D
T
F
V
G
R
I
R
K
D
--
L
D
A
--
E
K
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
T
L
H
E
R
G
18
PsiBlast_PDB
94.36
48%
-84
- C2 -
4R5H
8
?
A:
[3-338]
---
Y
T
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
P
I
D
K
I
R
Y
L
A
S
A
-
R
S
A
G
K
S
L
K
F
K
-----
D
Q
-------
D
I
T
I
E
E
T
T
E
T
A
F
E
G
--
V
D
I
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
-
A
V
K
-
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
P
E
V
N
-
A
H
A
L
-
D
---------
A
H
N
G
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
L
E
T
Q
R
E
L
R
E
V
L
N
D
G
V
K
--
P
C
D
L
-
H
A
E
I
L
P
S
G
G
D
K
K
H
Y
--------
P
I
A
F
N
A
L
P
Q
I
D
V
F
T
--
D
N
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
---------
D
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
P
G
A
V
L
E
D
D
V
---
A
H
------
Q
I
Y
P
Q
A
I
-
N
-
A
V
-
G
S
R
D
T
F
V
G
R
I
R
K
D
--
L
D
A
--
E
K
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
T
L
H
E
R
G
9
PsiBlast_PDB
94.29
48%
-86
- C2 -
3PZB
6
?
A:
[3-338]
---
Y
T
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
P
I
D
K
I
R
Y
L
A
S
A
-
R
S
A
G
K
S
L
K
F
K
-----
D
Q
-------
D
I
T
I
E
E
T
T
E
T
A
F
E
G
--
V
D
I
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
-
A
V
K
-
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
P
E
V
N
-
A
H
A
L
-
D
---------
A
H
N
G
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
L
E
T
Q
R
E
L
R
E
V
L
N
D
G
V
K
--
P
C
D
L
-
H
A
E
I
L
P
S
G
G
D
K
K
H
Y
--------
P
I
A
F
N
A
L
P
Q
I
D
V
F
T
--
D
N
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
---------
D
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
P
G
A
V
L
E
D
D
V
---
A
H
------
Q
I
Y
P
Q
A
I
-
N
-
A
V
-
G
S
R
D
T
F
V
G
R
I
R
K
D
--
L
D
A
--
E
K
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
T
L
H
E
R
G
16
PsiBlast_PDB
94.26
48%
-87
- C2 -
4R51
12
?
A:
[3-338]
---
Y
T
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
P
I
D
K
I
R
Y
L
A
S
A
-
R
S
A
G
K
S
L
K
F
K
-----
D
Q
-------
D
I
T
I
E
E
T
T
E
T
A
F
E
G
--
V
D
I
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
-
A
V
K
-
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
P
E
V
N
-
A
H
A
L
-
D
---------
A
H
N
G
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
L
E
T
Q
R
E
L
R
E
V
L
N
D
G
V
K
--
P
C
D
L
-
H
A
E
I
L
P
S
G
G
D
K
K
H
Y
--------
P
I
A
F
N
A
L
P
Q
I
D
V
F
T
--
D
N
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
---------
D
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
P
G
A
V
L
E
D
D
V
---
A
H
------
Q
I
Y
P
Q
A
I
-
N
-
A
V
-
G
S
R
D
T
F
V
G
R
I
R
K
D
--
L
D
A
--
E
K
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
T
L
H
E
R
G
15
PsiBlast_PDB
94.14
48%
-83
- C2 -
4R4J
6
?
A:
[3-338]
---
Y
T
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
P
I
D
K
I
R
Y
L
A
S
A
-
R
S
A
G
K
S
L
K
F
K
-----
D
Q
-------
D
I
T
I
E
E
T
T
E
T
A
F
E
G
--
V
D
I
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
-
A
V
K
-
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
P
E
V
N
-
A
H
A
L
-
D
---------
A
H
N
G
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
L
E
T
Q
R
E
L
R
E
V
L
N
D
G
V
K
--
P
C
D
L
-
H
A
E
I
L
P
S
G
G
D
K
K
H
Y
--------
P
I
A
F
N
A
L
P
Q
I
D
V
F
T
--
D
N
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
---------
D
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
P
G
A
V
L
E
D
D
V
---
A
H
------
Q
I
Y
P
Q
A
I
-
N
-
A
V
-
G
S
R
D
T
F
V
G
R
I
R
K
D
--
L
D
A
--
E
K
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
T
L
H
E
R
G
8
PsiBlast_PDB
94.04
48%
-83
- C2 -
3PYX
6
?
A:
[3-338]
---
Y
T
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
P
I
D
K
I
R
Y
L
A
S
A
-
R
S
A
G
K
S
L
K
F
K
-----
D
Q
-------
D
I
T
I
E
E
T
T
E
T
A
F
E
G
--
V
D
I
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
-
A
V
K
-
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
P
E
V
N
-
A
H
A
L
-
D
---------
A
H
N
G
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
L
E
T
Q
R
E
L
R
E
V
L
N
D
G
V
K
--
P
C
D
L
-
H
A
E
I
L
P
S
G
G
D
K
K
H
Y
--------
P
I
A
F
N
A
L
P
Q
I
D
V
F
T
--
D
N
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
---------
D
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
P
G
A
V
L
E
D
D
V
---
A
H
------
Q
I
Y
P
Q
A
I
-
N
-
A
V
-
G
S
R
D
T
F
V
G
R
I
R
K
D
--
L
D
A
--
E
K
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
T
L
H
E
R
G
12
PsiBlast_PDB
94.00
48%
-86
- C2 -
4R3N
7
?
A:
[3-338]
---
Y
T
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
P
I
D
K
I
R
Y
L
A
S
A
-
R
S
A
G
K
S
L
K
F
K
-----
D
Q
-------
D
I
T
I
E
E
T
T
E
T
A
F
E
G
--
V
D
I
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
-
A
V
K
-
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
P
E
V
N
-
A
H
A
L
-
D
---------
A
H
N
G
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
L
E
T
Q
R
E
L
R
E
V
L
N
D
G
V
K
--
P
C
D
L
-
H
A
E
I
L
P
S
G
G
D
K
K
H
Y
--------
P
I
A
F
N
A
L
P
Q
I
D
V
F
T
--
D
N
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
---------
D
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
P
G
A
V
L
E
D
D
V
---
A
H
------
Q
I
Y
P
Q
A
I
-
N
-
A
V
-
G
S
R
D
T
F
V
G
R
I
R
K
D
--
L
D
A
--
E
K
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
T
L
H
E
R
G
36
PsiBlast_CBE
93.84
48%
-84
- C2 -
3PWS
2
?
B:
[3-338]
---
Y
T
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
P
I
D
K
I
R
Y
L
A
S
A
-
R
S
A
G
K
S
L
K
F
K
-----
D
Q
-------
D
I
T
I
E
E
T
T
E
T
A
F
E
G
--
V
D
I
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
-
A
V
K
-
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
P
E
V
N
-
A
H
A
L
-
D
---------
A
H
N
G
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
L
E
T
Q
R
E
L
R
E
V
L
N
D
G
V
K
--
P
C
D
L
-
H
A
E
I
L
P
S
G
G
D
K
KH
Y
--------
P
I
A
F
N
A
L
P
Q
I
D
V
F
T
--
D
N
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
---------
D
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
P
G
A
V
L
E
D
D
V
---
A
H
------
Q
I
Y
P
Q
A
I
-
N
-
A
V
-
G
S
R
D
T
F
V
G
R
I
R
K
D
--
L
D
A
--
E
K
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
T
L
H
E
R
G
10
PsiBlast_PDB
93.57
48%
-83
- C2 -
3Q11
5
?
A:
[3-338]
---
Y
T
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
P
I
D
K
I
R
Y
L
A
S
A
-
R
S
A
G
K
S
L
K
F
K
-----
D
Q
-------
D
I
T
I
E
E
T
T
E
T
A
F
E
G
--
V
D
I
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
-
A
V
K
-
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
P
E
V
N
-
A
H
A
L
-
D
---------
A
H
N
G
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
L
E
T
Q
R
E
L
R
E
V
L
N
D
G
V
K
--
P
C
D
L
-
H
A
E
I
L
P
S
G
G
D
K
K
H
Y
--------
P
I
A
F
N
A
L
P
Q
I
D
V
F
T
--
D
N
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
---------
D
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
P
G
A
V
L
E
D
D
V
---
A
H
------
Q
I
Y
P
Q
A
I
-
N
-
A
V
-
G
S
R
D
T
F
V
G
R
I
R
K
D
--
L
D
A
--
E
K
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
T
L
H
E
R
G
25
PsiBlast_CBE
93.52
48%
-84
- C2 -
4R41
8
?
B:
[3-338]
---
Y
T
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
P
I
D
K
I
R
Y
L
A
S
A
-
R
S
A
G
K
S
L
K
F
K
-----
D
Q
-------
D
I
T
I
E
E
T
T
E
T
A
F
E
G
--
V
D
I
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
-
A
V
K
-
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
P
E
V
N
-
A
H
A
L
-
D
---------
A
H
N
G
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
L
E
T
Q
R
E
L
R
E
V
L
N
D
G
V
K
--
P
C
D
L
-
H
A
E
I
L
P
S
G
G
D
K
KH
Y
--------
P
I
A
F
N
A
L
P
Q
I
D
V
F
T
--
D
N
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
---------
D
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
P
G
A
V
L
E
D
D
V
---
A
H
------
Q
I
Y
P
Q
A
I
-
N
-
A
V
-
G
S
R
D
T
F
V
G
R
I
R
K
D
--
L
D
A
--
E
K
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
T
L
H
E
R
G
17
PsiBlast_PDB
93.47
48%
-86
- C2 -
4R54
4
?
A:
[3-338]
---
Y
T
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
P
I
D
K
I
R
Y
L
A
S
A
-
R
S
A
G
K
S
L
K
F
K
-----
D
Q
-------
D
I
T
I
E
E
T
T
E
T
A
F
E
G
--
V
D
I
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
-
A
V
K
-
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
P
E
V
N
-
A
H
A
L
-
D
---------
A
H
N
G
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
L
E
T
Q
R
E
L
R
E
V
L
N
D
G
V
K
--
P
C
D
L
-
H
A
E
I
L
P
S
G
G
D
K
K
H
Y
--------
P
I
A
F
N
A
L
P
Q
I
D
V
F
T
--
D
N
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
---------
D
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
P
G
A
V
L
E
D
D
V
---
A
H
------
Q
I
Y
P
Q
A
I
-
N
-
A
V
-
G
S
R
D
T
F
V
G
R
I
R
K
D
--
L
D
A
--
E
K
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
T
L
H
E
R
G
33
PsiBlast_CBE
93.11
48%
-83
- C2 -
3PYX
6
?
B:
[3-338]
---
Y
T
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
P
I
D
K
I
R
Y
L
A
S
A
-
R
S
A
G
K
S
L
K
F
K
-----
D
Q
-------
D
I
T
I
E
E
T
T
E
T
A
F
E
G
--
V
D
I
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
-
A
V
K
-
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
P
E
V
N
-
A
H
A
L
-
D
---------
A
H
N
G
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
L
E
T
Q
R
E
L
R
E
V
L
N
D
G
V
K
--
P
C
D
L
-
H
A
E
I
L
P
S
G
G
D
K
KH
Y
--------
P
I
A
F
N
A
L
P
Q
I
D
V
F
T
--
D
N
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
---------
D
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
P
G
A
V
L
E
D
D
V
---
A
H
------
Q
I
Y
P
Q
A
I
-
N
-
A
V
-
G
S
R
D
T
F
V
G
R
I
R
K
D
--
L
D
A
--
E
K
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
T
L
H
E
R
G
46
HHSearch
87.15
35%
-88
- C2 -
3TZ6
10
DHAS_MYCTU
A:
[1-342]
--
G
L
S
I
G
I
V
G
A
T
G
Q
V
G
Q
V
M
R
T
L
L
D
E
R
D
F
P
A
S
A
V
R
F
F
A
S
A
-
R
S
Q
G
R
K
L
A
F
R
-----
G
Q
-------
E
I
E
V
E
D
A
E
--
T
A
D
P
S
G
L
D
I
A
L
F
S
A
G
S
A
M
S
K
V
Q
A
P
R
-
F
A
A
A
G
V
T
V
I
-
D
N
S
S
A
W
R
K
D
P
D
V
P
L
V
V
S
E
V
N
-
F
E
R
D
A
H
R--------
R
P
K
G
I
I
A
N
P
N
C
T
T
M
A
A
M
P
V
L
K
V
L
H
D
E
A
R
L
V
R
L
V
V
S
S
Y
Q
A
V
S
G
S
G
L
A
G
V
A
E
L
A
E
Q
A
R
A
V
I
G
G
A
E
Q
L
V
Y
D
G
G
A
L
-
E
F
P
P
P
N
T
Y
V
--
A
--------
P
I
A
F
N
V
V
P
L
A
G
S
L
V
DD
G
S
G
E
--
T
D
E
D
Q
K
L
R
F
E
S
R
K
I
L
G
I
P--------
D
-
L
L
V
S
G
T
C
V
R
V
P
V
F
T
G
H
S
L
S
I
N
A
E
F
A
Q
P
L
S
P
E
R
A
R
E
L
L
D
G
A
T
G
V
Q
L
V
D
---------------
V
P
T
P
L
-
A
-
A
A
-
G
V
D
E
S
L
V
G
R
I
R
R
D
--
P
G
V
PD
G
R
G
L
A
L
F
V
S
G
D
N
L
R
K
G
A
A
L
N
T
I
Q
I
A
E
L
L
T
A
--
43
PsiBlast_CBE
84.59
35%
-84
- C2 -
3TZ6
10
DHAS_MYCTU
A:
[3-337]
----
S
I
G
I
V
G
A
T
G
Q
V
G
Q
V
M
R
T
L
L
D
E
R
D
F
P
A
S
A
V
R
F
F
A
S
A
-
R
S
Q
G
R
K
L
A
F
R
-----
G
Q
-------
E
I
E
V
E
D
A
--
E
T
A
D
P
S
G
L
D
I
A
L
F
S
A
G
S
A
M
S
K
V
Q
A
P
R
F
A
A
A
-
G
V
T
V
I
-
D
N
S
S
A
W
R
K
D
P
D
V
P
L
V
V
S
E
V
N
F
E
R
D
A
H
R
---------
R
P
K
G
I
I
A
N
P
N
C
T
T
M
A
A
M
P
V
L
K
V
L
H
D
E
A
R
L
V
R
L
V
V
S
S
Y
Q
A
V
S
G
S
G
L
A
G
V
A
E
L
A
E
Q
A
R
A
V
I
G
G
A
E
Q
---------
L
V
Y
D
G
G
A
L
E
--
F
PPPNTYVA
P
I
A
F
N
V
V
P
L
A
G
S
L
V
--
D
D
G
S
GE
T
D
E
D
Q
K
L
R
F
E
S
R
K
I
L
G
I
P--------
D
-
L
L
V
S
G
T
C
V
R
V
P
V
F
T
G
H
S
L
S
I
N
A
E
F
A
Q
P
L
S
P
E
R
A
R
E
L
L
D
G
A
T
G
V
Q
L
V
D
---------------
V
P
T
P
L
-
A
-
A
A
-
G
V
D
E
S
L
V
G
R
I
R
R
D
PG
V
P
D
--
G
R
G
L
A
L
F
V
S
G
D
N
L
R
K
G
A
A
L
N
T
I
Q
I
A
E
L
L
T
A
--
44
PsiBlast_CBE
83.59
35%
-86
- C2 -
3VOS
9
DHAS_MYCTU
A:
[21-355]
----
S
I
G
I
V
G
A
T
G
Q
V
G
Q
V
M
R
T
L
L
D
E
R
D
F
P
A
S
A
V
R
F
F
A
S
A
-
R
----
K
L
A
F
R
-----
G
Q
-------
E
I
E
V
E
D
A
--
E
T
A
D
P
S
G
L
D
I
A
L
F
S
A
G
S
A
M
S
K
V
Q
A
P
R
F
A
A
A
-
G
V
T
V
I
-
D
N
S
S
A
W
R
K
D
P
D
V
P
L
V
V
S
E
V
N
F
E
R
D
A
H
R
---------
R
P
K
G
I
I
A
N
P
N
C
T
T
M
A
A
M
P
V
L
K
V
L
H
D
E
A
R
L
V
R
L
V
V
S
S
Y
Q
A
V
S
G
S
G
L
A
G
V
A
E
L
A
E
Q
A
R
A
V
I
G
G
A
E
Q
---------
L
V
Y
D
G
G
A
L
E
--
F
PPPNTYVA
P
I
A
F
N
V
V
P
L
A
G
S
L
V
--
D
D
G
S
GE
T
D
E
D
Q
K
L
R
F
E
S
R
K
I
L
G
I
P--------
D
-
L
L
V
S
G
T
C
V
R
V
P
V
F
T
G
H
S
L
S
I
N
A
E
F
A
Q
P
L
S
P
E
R
A
R
E
L
L
D
G
A
T
G
V
Q
L
V
D
---------------
V
P
T
P
L
-
A
-
A
A
-
G
V
D
E
S
L
V
G
R
I
R
R
D
PG
V
P
D
--
G
R
G
L
A
L
F
V
S
G
D
N
L
R
K
G
A
A
L
N
T
I
Q
I
A
E
L
L
T
---
56
HHSearch
76.81
33%
-81
- C2 -
1YS4
4
DHAS_METJA
A:
[7-352]
-
M
K
I
K
V
G
V
L
G
A
T
G
S
V
G
Q
R
F
V
Q
L
L
A
D
--
H
P
M
F
E
L
T
A
L
A
A
S
E
R
S
A
G
K
K
Y
K
D
A
C
YWFQ
D
R
DIPENIK
D
M
V
V
I
P
T
D
P
K
H
E
E
F
E
D
V
D
I
V
F
S
A
L
P
S
D
L
A
K
K
F
E
P
E
-
F
A
K
E
G
K
L
I
F
-
S
N
A
S
A
Y
R
M
E
E
D
V
P
L
V
I
P
E
V
N
-
A
D
H
L
E
L
I
E
I
Q
R
E
K
RG
W
D
G
A
I
I
T
N
P
N
C
S
T
I
C
A
V
I
T
L
K
P
I
M
D
K
F
G
L
E
A
V
F
I
A
T
M
Q
A
V
S
G
A
G
Y
N
G
V
P
S
----------------------------------
M
--------
A
I
L
D
N
L
I
P
F
I
K
------------
N
E
E
E
K
M
Q
T
E
S
L
K
L
L
G
T
L
K
DGKVELA
N
-
F
K
I
S
A
S
C
N
R
V
A
V
I
D
G
H
T
E
S
I
F
V
K
T
K
E
G
A
E
P
E
E
I
K
E
V
M
D
K
F
D
P
L
K
D
L
N
L
P
TYA
K
P
I
V
I
R
EE
I
D
R
P
Q
P
R
L
D
R
N
E
G
N
G
M
S
I
V
V
G
R
I
R
K
D
--
P
I
----
F
D
V
K
Y
T
A
L
E
H
N
T
I
R
G
A
A
G
A
S
V
L
N
A
E
Y
F
V
K
K
Y