@TOME V2.3
(Nov 2016)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_1121: (2015-12-21 )
MSKKIPLKNRLRADFTKTPTDLEVPNLLLLQRDSYDSFLYSKDGKESGIEKVFKSIFPIQDEHNRITLEYAGCEFGKSKYTVREAMERGITYSIPLKIKVRLILWEKDTKSGEKNGIKDIKEQSIFIREIPLMTERTSFIINGVERVVVNQLYRSPGVIFKEEESSTSSNKLIYTGQIIPDRGSWLYFEYDSKDVLYARINKRRKVPVTILFRAMDYQKQDIIKMFYPLVKVRYENDKYLIPFASLDANQRMEFDLKDPQGKIILLAGKKLTSRKIKELKENHLEWVEYPMDILLNRHLAEPVMVGKEVLLDMLTQLDKNRLEKIHDLGVQEFVIINDLALGHDASIIHSFSADHESLKLLKQTEKIDDENALAAIRIHKVMKPGDPVTTEVAKQFVKKLFFDPERYDLTMVGRMKMNHKLGLHVPDYITTLTHEDIITTVKYLMKIKNNQGKIDDRDHLGNRRIRAVGELLANELHSGLVKMQKTIKDKLTTMSGAFDSLMPHDLVNSKMITSTIMEFFMGGQLSQFMDQTNPLSEVTHKRRLSALGEGGLVKDRVGFEARDVHPTYYGQFGPIETPEGQNIGLINTLSTFTRVNDLGFIEAPYKKVVDGKVAGETIYLTAIQEDSHIIAPASTPIDEEGNILGDLIETRVEGEIVLNEKSKVTLMDLSSSMLVGVAASLIPFLEHDDANRALMGTNMQRQAVPLLRSDAPIVGTGIEKIIARDSWGAIKANRAGVVEKIDSKNIYILGEGKEEAYIDAYSLQKNLRTNQNTSFNQVPIVKVGDKVEAGQIIADGPSMDRGELALGKNVRVAFMPWNGYNFEDAIVVSERITKDDVFTSTHIYEKEVDARELKHGVEEFTADIPDVKEEALAHLDESGIVKVGTYVSAGMILVGKTSPKGEIKSTPEERLLRAIFGDKAGHVVNKSLYCPPSLEGTVIDVKVFTKKGYEKDARVLSAYEEEKAKLDMEHFDRLTMLNREELLRVSSLLSQAILEEPFSHNGKDYKEGDQIPKEEIASINRFTLASLVKKYSKEVQNHYEITKNNFLEQKKVLGEEHEEKLSILEKDDILPNGVIKKVKLYIATKRKLKVGDKMAGRHGNKGIVSNIVPVADMPYTADGEPVDIVLNPLGVPSRMNIGQILEMHLGLVGKEFGKQIASMLEDKTKDFAKELRAKMLEIANAINEKDPLTIHVLENCSDEELLEYAKDWSKGVKMAIPVFEGISQEKFYKLFELAKIAMDGKMDLYDGRTGEKMRERVNVGYMYMIKLHHLVDEKVHARSTGPYSLVTHQPVGGKALFGGQRFGEMEVWALEAYGAAHTLKEMLTIKSDDIRGRENAYRAIAKGEQVGESEIPETFYVLTKELQSLALDINIFGDDVDEDGAPRPIMIKEDDRPKDFSSFQLTLASPEKIHSWSYGEVKKPETINYRTLKPERDGLFCMKIFGPTKDYECLCGKYKKPRFKDIGTCEKCGVAITHSKVRRFRMGHIELATPVAHIWYVNSLPSRIGTLLGVKMKDLERVLYYEAYIVKEPGEAAYDNEGTKLVMKYDILNEEQYQNISRRYEDRGFVAQMGGEAIKDLLEEIDLITLLQSLKEEVKDTNSDAKKKKLIKRLKVVESFLNSGNRPEWMMLTVLPVLPPDLRPLVALDGGKFAVSDVNELYRRVINRNQRLKRLMELGAPEIIVRNEKRMLQEAVDVLFDNGRSTNAVKGANKRPLKSLSEIIKGKQGRFRQNLLGKRVDFSGRSVIVVGPNLKMDECGLPKNMALELFKPHLLSKLEERGYATTLKQAKRMIEQKSNEVWECLQEITEGYPVLLNRAPTLHKQSIQAFHPKLIDGKAIQLHPLVCSAFNADFDGDQMAVHVPLSQEAIAECKVLMLSSMNILLPASGKAVAIPSQDMVLGLYYLSLEKSGVKGEHKLFSSVNEIITAIDTKELDIHAKIRVLDQGNIIATSAGRMIIKSILPDFIPTDLWNRPMKKKDIGVLVDYVHKVGGIGITATFLDHLKTLGFRYATKAGISISMEDIITPKDKQKMVEKAKVEVKKIQQQYDQGLLTDQERYNKIIDTWTEVNDRMSKEMMSAIAKDKEGFNSIYMMADSGARGSAAQIRQLSAMRGLMTKPDGSIIETPIISNFKEGLNVLEYFNSTHGARKGLADTALKTANAGYLTRKLIDVSQNVKVVSDDCGTHEGIEITDIAVGSELIEPLEERIFGRVLLEDVIDPITNEILLYADTLIDEEGAKKVVEAGIKSITIRTPVTCKAPKGVCAKCYGLNLGEGKMSYPGEAVGVVAAQSIGEPGTQLTLRTFHVGGTASRSQDEREIVASKEGFVRFYNLRTYTNKEGKNIIANRRNASILVVEPKIKAPFDGELRIETVYEEVVVSVKNGDQEAKFVLRRSDIVKPSELAGVGGKIEGKVYLPYASGHKVHKGGSIADIIQEGWNVPNRIPYASELLVKDNDPIAQDVYAKEKGVIKYYVLEANHLERTHGVKKGDIVSEKGLFAVVADDNGREAARHYIARGSEILIDDNSEVSANSVISKPTTNTFKTIATWDPYNTPIIADFKGKVNFVDVIAGVTVAEKEDENTGITSLVVNDYIPSGYKPSLFLEGANGEEMRYFLEPKTSIAISDGSSVEQAEVLAKIPKATVKSRDITGGLPRVSELFEARKPKPKDVAILSEVDGIVSFGKPIRNKEHIIVTSKDGRLTDYFVDKGKQILVHADEFVHAGEAMTDGVVSSHDILRISGEKELYKYIVSEVQQVYRRQGVSIADKHIEIIVSQMLRQVRILDSGDSKFIEGDLVSKKLFKEENTRVIALKGEPAIAEPVLLGITRAAIGSDSIISAASFQETTKVLTEASIAMKKDFLEDLKENVVLGRMIPVGTGMYKNKKIVLRALEDNSKF
Atome Classification :
(26 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.....-..170.......180.......190.......200.......210.......220.......230.......---240.......250.......260.......270.......280.......290.......300..----------.....310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750..----.....760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050......1060----.......1070......1080......1090......1100......1110......1120......1130......1140......1150......1160......--1170......1180......1190......1200......1210......1220......1230......1240......1250......1260......1270......1280......1290......1300......1310......1320......1330......1340......1350......1360......1370......1380......1390......1400......1410......1420......1430......1440......1450......1460......1470......1480......1490......1500......1510......1520......1530...---------------.-.-----.1540.------.-------------------------------------------..--------------------------....1550------------------.---------------------.-----------------------....1560------------.........1570......1580......1590......1600......1610......1620......1630......1640......1650......1660......1670......1680......1690......1700...-...1710......1720......1730......1740......1750......1760......1770......1780......1790---......1800......1810......1820......1830......1840......1850......1860......1870......1880......1890......1900......1910......1920......1930......1940-----------------------------------........1950......1960..-----..--..1970......1980......1990......2000......2010......2020......2030......2040......2050......2060......2070......2080......2090......2100......2110......2120......2130......2140......2150......2160......2170......2180......2190.-------.....2200......2210......2220......2230.....----.2240......2250......2260......2270......2280......2290......2300......2310......2320......2330......2340......2350......2360......2370......2380......2390......2400......2410......2420......2430......2440......2450......2460......2470......2480......2490......2500......2510......2520......2530......2540......2550......2560......2570......2580......2590......2600......2610......2620......2630......2640......2650......2660......2670......2680......2690......2700......2710......2720......2730......2740......2750......2760......2770......2780......2790......2800......2810......2820......2830......2840......2850......2860......2870......2880......2890
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSKKIP
L
K
N
R
LRADFTKTPTDLEVP
N
L
L
L
L
QRDSYDS
F
L
YSKDG
K
E
S
G
I
E
K
V
F
K
S
IFPIQDEH
N
R
I
T
L
E
YAGCEFGKSK
Y
T
V
R
E
A
M
ERGI
T
Y
S
I
P
L
K
I
K
V
R
L
I
L
W
EKDTKSGEKN
G
I
K
D
I
K
EQ
S
I
F
I
REIPL
M
T
E
R
T
S
F
I
I
N
G
V
E
R
V
V
V
N
Q
L
Y
RSPG
V
I
F
KEEESST-SS
N
K
L
I
Y
T
G
Q
IIPDRG
S
W
L
Y
F
E
YDSK
D
V
L
Y
A
R
INKRRKVP
V
T
I
L
F
RAMD
Y
Q
K
Q
D
I
I
K
M
F
Y
P
L
V
K
V
R
YEND
K
Y
---
L
I
P
F
ASLDANQ
R
M
E
F
D
LKDPQG
K
I
I
L
L
AGK
K
L
T
S
R
K
I
K
E
L
K
E
N
H
L
E
W
V
E
Y
P
M
D
I
L
L
N
RHLAE
P
V
M
----------
V
G
K
E
V
L
L
D
M
L
T
Q
L
D
K
N
R
L
E
K
I
H
DLGV
Q
E
F
V
I
I
N
D
LALGH
D
A
S
I
I
H
SFSA
D
H
E
S
L
K
L
L
K
Q
T
EKIDDEN
A
L
A
A
I
R
I
H
KVMKPGDP
V
T
T
E
V
A
K
Q
F
V
K
K
LFFDPER
Y
D
L
T
M
V
G
R
M
K
MNHKLGLHV
P
D
Y
I
T
T
L
T
H
E
D
I
I
T
T
V
K
Y
L
M
K
IKNNQGKID
D
R
D
HLG
N
R
R
I
R
A
V
G
E
L
L
A
N
E
L
H
S
G
L
V
K
M
Q
K
T
I
K
D
K
L
T
T
MS
G
A
F
D
SLM
P
H
D
LVN
S
K
M
I
T
S
T
I
M
E
F
F
MGG
Q
L
S
Q
F
M
DQTN
P
L
S
E
V
T
H
K
R
R
L
S
A
LGEGGLVKDRVGFEARDVHPTYYGQFGPIETPEGQN
I
G
L
I
N
T
L
S
T
F
T
RVNDLGFIE
A
P
Y
K
K
VVDGKVAG
E
T
I
Y
L
T
A
IQED
S
H
I
IAPASTPIDEEG
N
I
L
G
D
L
I
E
T
RVE
G
E
I
V
LNEKS
K
V
T
L
M
DLSS
S
M
L
V
G
V
A
A
S
L
I
P
F
LEHDDANRALMGTNM
Q
R
QAVPLLRSDAPI
V
G
T
G
I
E
K
I
I
ARDSWGAIKANRAGV
V
E
KIDSK
N
I
Y
I
L
GEGKE----
E
A
Y
I
D
A
Y
S
L
Q
K
N
LRTNQNTSFNQV
P
I
V
KVGDKVEA
G
Q
I
IADGPSMDRG
E
L
ALGKN
V
R
V
A
F
MPWNGYNFE
D
A
I
V
V
SERITKDDVFTST
H
I
YEKEV
D
A
R
E
L
K
H
G
V
E
E
F
TADIP
D
V
K
E
E
A
L
A
HLDESG
I
V
K
V
G
T
Y
V
SA
G
M
I
L
V
GKTSPKGEIKST
P
E
E
R
L
L
R
A
I
FGDKAG
H
V
VNKSLYCPPSLEG
T
V
I
D
V
K
V
F
TKKGY
E
K
D
A
R
V
L
S
A
Y
E
E
E
K
AKL
D
M
E
H
F
D
R
L
TML
N
R
E
E
L
L
R
V
S
S
L
L
S
Q
A
I
L
EEPFSHNGKDYKEGDQI
P
K
E
E
I
A
S
I
N
R
F
T
L
A
S
L
V
K
K
Y
S
K
E
V
Q
N
H
YEI
T
K
N
N
F
L
E
Q
K
K
V
LG
E
E
H
E
E
K
L
S
-----
I
L
EKDDILPN
G
V
I
K
K
V
K
L
Y
I
A
T
K
R
K
LKVG
D
K
M
AGRHGNK
G
I
V
SNIVPVADMPYTADG
E
P
V
D
I
V
L
NPLGVPSRM
N
I
G
Q
I
L
E
M
H
L
G
L
V
G
K
E
F
G
K
Q
I
A
S
M
L
E
D
K
T
K
D
F
A
K
--
E
L
R
A
K
M
L
E
I
A
N
A
INEKD
P
L
T
I
H
VLENC
S
D
E
E
L
L
E
Y
A
K
D
W
SKGV
K
M
A
I
P
V
FEGI
S
Q
E
K
F
Y
K
L
F
E
L
A
K
I
AMDGK
M
D
LYDGRT
G
E
K
M
R
E
R
VNVG
Y
M
Y
M
I
K
L
H
H
L
V
D
E
K
VHARSTG
P
Y
S
L
V
THQPVGGKALFGGQRFGE
M
E
V
W
A
L
EAY
G
A
A
H
T
L
K
E
M
L
T
IKSDDIRG
R
E
N
A
Y
R
A
I
AKGEQVGESEI
P
E
T
F
Y
V
L
T
K
E
L
Q
S
L
A
L
D
I
N
I
FGDDVDEDGAPR
P
I
M
IKEDDRPKDFS
S
F
Q
L
T
LAS
P
E
K
IHSWSYGEVKKPETIN
Y
R
TLKPERD
G
L
F
C
M
K
IFGPTK
D
Y
E
C
L
CGKYKKPRFKDIG
T
C
E
K
C
G
V
A
I
T
H
S
K
V
R
R
F
RMG
H
I
E
LAT
P
V
A
H
I
W
Y
V
N
S
L
P
S
R
I
G
T
L
LGV
K
M
K
D
L
E
R
V
L
Y
Y
E
A
Y
I
V
KEPGEAAYDN---------------E-G-----
T
K
--
L
V
------
M
-------------------------------------------
K
Y--------------------------DIL
N
E
E
Q
Y
------------------
Q
---------------------
N
-----------------------
I
S
R
R
Y
---------------EDR
G
F
V
A
Q
M
G
G
E
A
I
K
D
L
L
E
E
I
D
L
I
T
L
L
Q
S
L
K
E
E
V
KDTN
S
D
A
K
K
K
K
L
I
K
R
L
K
V
V
E
S
F
L
NSGNR
P
E
W
M
M
L
T
VLPVLPPDL
R
P
L
V
A
LDGG
K
F
A
V
S
D
V
N
E
L
Y
R
R
V
I
N
R
N
Q
R
L
K
R
L
M
E
LGA
P
E
I
I
VR
N
E
K
R
M
L
Q
E
A
V
D
V
L
FDNGRSTNAVK-GANKR
P
L
K
S
L
S
E
I
I
KGKQG
R
F
R
Q
N
L
LGKRVDFSG
R
S
V
I
V
VGPNLKMDECGLP
K
N
M
A
L
E
L
F
K
P
H
L
L
S
K
L
E
ERG
Y
A
T
T
L
K
Q
A
K
R
M
I
E
QK---S
N
E
V
W
E
C
L
Q
E
I
TEG
Y
P
V
L
LNRAP
T
L
H
K
Q
S
I
Q
A
FHPKLIDG
K
A
I
Q
L
H
P
L
V
C
S
AFNADFDGD
Q
M
A
V
H
VPL
S
Q
E
A
I
A
E
C
K
V
L
M
L
SS
M
N
I
L
LPASG
K
A
V
AIPSQ
D
M
V
L
G
L
Y
Y
L
S
LEKSGVK
G
E
H
K
L
F
S
S
V
N
E
I
I
T
AIDTK
E
L
D
I
H
A
K
I
R
V
L
D-------------------------------------QG
N
I
I
ATSA
G
R
M
I
I
K
S
I
L
P
D
FI
P
T
-----
D
L--WNRPMKK
K
D
I
G
V
L
V
D
Y
V
H
K
VGGI
G
I
T
A
T
F
L
D
H
L
K
T
L
G
F
R
YATKAG
I
S
I
S
M
E
DIIT
P
K
D
K
Q
K
M
V
E
K
A
K
V
E
V
K
K
I
Q
Q
Q
Y
D
QGLLT
D
Q
E
R
Y
N
K
I
I
D
T
W
T
E
V
N
D
R
M
S
K
E
M
M
S
A
I
AKDKEGF
N
S
I
Y
M
M
ADSGARG
S
A
A
Q
I
R
Q
L
S
A
M
RGLMTKPDG
S
I
IE
T
P
I
I
S
N
F
K
E
G
L
N
V
L
E
Y
F
NSTHGARKG
L
A
D
T
A
L
KTAN
A
G
Y
L
T
R
K
L
I
DVSQN
V
K
V
VSDDCGTHEG
I
E
I
T
D
I
AV
G
S
-------
E
L
I
E
P
L
E
E
R
I
F
G
R
V
L
L
E
D
V
I
D
P
I
TNE
I
L
L
Y
A
D
T
LI
D
E
E
G
A
K
K
V
V
----
E
AGI
K
S
I
T
I
RT
P
V
TCKAPK
G
V
C
A
K
CYGLNLGEGKMSYPG
E
A
V
G
V
V
A
A
Q
SIGEPG
T
Q
L
T
L
R
T
F
H
VGGTASRS
Q
D
E
R
E
I
V
ASKEG
F
V
R
F
Y
N
L
R
T
YTNKEG
K
N
I
IANRRN
A
S
I
L
V
VEPKIKAPFDG
E
L
R
I
E
T
V
Y
E
E
V
V
V
SVKNGD
Q
E
A
K
F
V
L
RRSDIV
K
P
S
E
LAGVGGKIE
G
K
V
Y
L
P
YASGHKVHKGG
S
I
A
D
I
I
Q
EGWNVPNRIPY
A
S
E
LLVKDNDP
I
A
Q
D
V
Y
AKEKG
V
I
K
Y
Y
V
L
EANH
L
E
R
THGVKKGDIVSEK
G
L
F
A
V
V
ADDN
G
R
E
A
A
R
H
Y
IARG
S
E
I
L
I
DDNSEVSANSVISKPTTN
T
F
K
T
I
A
TWDPYNT
P
I
I
A
DFKGK
V
N
F
V
D
V
IAG
V
T
V
AEKEDENTG
I
T
S
L
V
VNDYIPSGYK
P
S
L
F
L
EGANGE
E
M
R
Y
F
LEPK
T
S
I
A
ISDGSS
V
E
Q
A
E
V
L
A
KIP
K
A
TVKSRDITGG
L
P
R
V
S
E
L
F
E
ARKPKPK
D
V
A
I
L
S
EV
D
G
I
V
SFGKPIRNK
E
H
I
I
V
TSKDG
R
L
T
D
Y
F
VDKG
K
Q
I
L
V
H
A
D
E
F
VHAGEAMTDGVVSSH
D
I
L
R
IS
G
E
K
E
L
Y
K
Y
I
V
S
E
V
Q
Q
V
Y
R
RQGV
S
I
A
D
K
H
I
E
I
I
V
S
Q
M
L
R
Q
V
RILDSGDSKFIE
G
D
L
V
S
K
K
L
FKEEN
T
R
V
I
A
LKGEPAIA
E
P
V
L
L
G
I
T
R
A
AIGSD
S
I
I
S
A
A
S
F
Q
E
T
T
K
V
L
T
E
A
S
I
A
M
K
K
D
F
L
E
D
L
K
ENVVLGRMIPVGTGMYKN
K
K
I
V
L
R
ALEDNSKF
42
PsiBlast_CBE
81.26
46%
-53
- C7 -
4MEX
1
RPOB_ECOLI
I:
[8-1339]
-------
K
K
R
I
R
K
D
F
G
K
R
P
Q
V
L
D
V
P
Y
L
L
S
I
Q
L
D
S
F
Q
K
F
I
E
Q
D
P
E
G
Q
Y
G
L
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A
A
F
R
S
V
F
P
I
Q
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Y
S
G
N
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E
L
Q
Y
V
S
Y
R
L
G
E
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V
F
D
V
Q
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C
Q
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S
A
P
L
R
V
K
L
R
L
V
I
Y
E
R
E
A
P
E
G
T
---
V
K
D
I
K
E
Q
E
V
Y
M
G
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I
P
L
M
T
D
N
G
T
F
V
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G
T
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R
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S
Q
L
H
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P
G
V
F
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D
K
G
K
T
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S
G
K
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Y
N
A
R
I
I
P
Y
R
G
S
W
L
D
F
E
F
D
P
K
D
N
L
F
V
R
I
D
R
R
R
K
L
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A
T
I
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R
A
L
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Y
T
T
E
Q
I
L
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F
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K
L
QME
L
V
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--
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R
L
R
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A
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F
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G
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L
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V
V
A
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D
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I
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A
N
M
E
L
S
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L
L
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L
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------
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---------
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L
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-----
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--
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V
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L
I
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F
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D
D
A
N
R
A
L
M
G
A
N
M
Q
R
Q
A
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L
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A
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G
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R
A
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Y
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I
V
I
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V
N
E
D
E
MYPG
E
A
G
I
D
I
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L
T
K
Y
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N
Q
N
T
C
I
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L
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M
R
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D
R
F
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T
I
H
I
Q
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A
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V
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L
G
P
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T
A
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P
N
V
G
E
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K
L
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I
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V
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N
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D
V
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T
R
D
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V
E
K
D
K
R
A
L
E
I
E
E
M
Q
L
K
Q
A
K
K
D
L
S
E
E
L
Q
I
L
E
A
G
L
F
S
R
I
R
A
V
L
V
A
G
---------
G
V
E
A
E
K
L
D
K
L
P
R
------
D
R
W
L
E
L
G
L
T
---
D
E
E
K
Q
N
Q
L
E
----
Q
L
A
E
Q
Y
D
E
L
K
H
E
F
E
K
K
L
E
AKRRK
I
T
Q
G
D
D
L
A
P
-
G
V
L
K
I
V
K
V
Y
L
A
V
K
R
R
I
Q
P
G
D
K
M
A
G
R
H
G
N
K
G
V
I
S
K
I
N
P
I
E
D
M
P
Y
D
E
N
G
T
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V
D
I
V
L
N
P
L
G
V
P
S
R
M
N
I
G
Q
I
L
E
T
H
L
G
M
A
A
K
G
I
G
D
K
I
N
A
M
L
K
-
Q
Q
Q
E
V
A
K
LR
E
F
I
Q
R
A
Y
D
L
G
A
D
V
R
Q
K
V
D
L
S
-----
T
F
S
D
E
E
V
M
R
L
A
E
N
L
R
K
G
M
P
I
A
T
P
V
F
D
G
A
K
E
A
E
I
K
E
L
L
K
L
G
D
L
P
T
S
G
Q
I
R
L
Y
D
G
R
T
G
E
Q
F
E
R
P
V
T
V
G
Y
M
Y
M
L
K
L
N
H
L
V
D
D
K
M
H
A
R
S
T
G
S
Y
S
L
V
T
Q
Q
P
L
G
G
K
A
Q
F
G
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R
F
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V
W
A
L
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A
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G
A
A
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L
Q
E
M
L
T
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K
S
D
D
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N
G
R
T
K
M
Y
K
N
I
V
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H
Q
M
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M
P
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L
L
K
E
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R
S
L
G
I
N
I
E
L
E
D
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
PsiBlast_CBE
81.13
46%
-53
- C7 -
4XSZ
1
?
I:
[8-1339]
-------
K
K
R
I
R
K
D
F
G
K
R
P
Q
V
L
D
V
P
Y
L
L
S
I
Q
L
D
S
F
Q
K
F
I
E
Q
D
P
E
G
Q
Y
G
L
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A
A
F
R
S
V
F
P
I
Q
S
Y
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S
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L
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Y
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L
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F
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C
Q
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S
A
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L
R
V
K
L
R
L
V
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Y
E
R
E
A
P
E
G
T
---
V
K
D
I
K
E
Q
E
V
Y
M
G
E
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L
M
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N
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F
V
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L
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A
R
I
I
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Y
R
G
S
W
L
D
F
E
F
D
P
K
D
N
L
F
V
R
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R
R
R
K
L
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A
T
I
I
L
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A
L
N
Y
T
T
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Q
I
L
D
L
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F
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K
V
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R
D
N
K
L
QME
L
V
P
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L
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G
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A
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R
L
S
-----
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Y
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MYPG
E
A
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L
T
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Y
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L
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A
G
L
F
S
R
I
R
A
V
L
V
A
G
---------
G
V
E
A
E
K
L
D
K
L
P
R
------
D
R
W
L
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L
G
L
T
---
D
E
E
K
Q
N
Q
L
E
----
Q
L
A
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Q
Y
D
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L
K
H
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F
E
K
K
L
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AKRRK
I
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E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
81.05
46%
-53
- C7 -
4YFK
2
RPOB_ECO24
C:
[8-1339]
-------
K
K
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E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
114
HHSearch
81.04
51%
-58
- C6 -
2A6H
4
RPOC_THET8
D:
[3-1486]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
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I
Q
K
V
Y
R
A
Q
G
V
K
L
H
D
K
H
I
E
I
V
V
R
Q
M
M
K
Y
V
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V
T
D
P
G
D
S
R
L
L
E
G
Q
V
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K
W
D
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A
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N
E
R
L
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G
K
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P
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A
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T
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A
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D
F
V
R
F
T
Q
V
V
D
Q
K
T
L
K
A
I
39
PsiBlast_CBE
81.00
46%
-52
- C7 -
4XSY
1
?
C:
[8-1339]
-------
K
K
R
I
R
K
D
F
G
K
R
P
Q
V
L
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T
---
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A
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L
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---------
G
V
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A
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L
D
K
L
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R
------
D
R
W
L
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L
T
---
D
E
E
K
Q
N
Q
L
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----
Q
L
A
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Q
Y
D
E
L
K
H
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F
E
K
K
L
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A
K
R
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G
D
D
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A
P
-
G
V
L
K
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V
K
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Y
L
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K
R
R
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Q
P
G
D
K
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V
P
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T
H
L
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M
A
A
K
G
I
G
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K
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N
A
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-
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A
K
L
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-----
T
F
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A
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N
L
R
K
G
M
P
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A
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A
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L
L
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D
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G
R
T
G
E
Q
F
E
R
P
V
T
V
G
Y
M
Y
M
L
K
L
N
H
L
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D
D
K
M
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Q
P
L
G
G
K
A
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W
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A
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G
R
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K
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L
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L
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E
L
E
D
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
PsiBlast_CBE
81.00
46%
-53
- C7 -
4XSZ
1
?
C:
[8-1339]
-------
K
K
R
I
R
K
D
F
G
K
R
P
Q
V
L
D
V
P
Y
L
L
S
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Q
L
D
S
F
Q
K
F
I
E
Q
D
P
E
G
Q
Y
G
L
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A
A
F
R
S
V
F
P
I
Q
S
Y
S
G
N
S
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L
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S
Y
R
L
G
E
P
V
F
D
V
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C
Q
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S
A
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L
R
V
K
L
R
L
V
I
Y
E
R
E
A
P
E
G
T
---
V
K
D
I
K
E
Q
E
V
Y
M
G
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P
L
M
T
D
N
G
T
F
V
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N
G
T
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R
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L
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V
F
F
D
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K
G
K
T
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N
A
R
I
I
P
Y
R
G
S
W
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F
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F
D
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D
N
L
F
V
R
I
D
R
R
R
K
L
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A
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A
L
N
Y
T
T
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Q
I
L
D
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K
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D
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L
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M
E
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--
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K
V
V
A
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ESTGELICA
A
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M
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L
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L
L
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------
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R
L
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-----
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R
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T
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A
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L
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G
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------
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W
L
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---
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P
T
S
G
Q
I
R
L
Y
D
G
R
T
G
E
Q
F
E
R
P
V
T
V
G
Y
M
Y
M
L
K
L
N
H
L
V
D
D
K
M
H
A
R
S
T
G
S
Y
S
L
V
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
Y
T
L
Q
E
M
L
T
V
K
S
D
D
V
N
G
R
T
K
M
Y
K
N
I
V
D
G
N
H
Q
M
E
P
G
M
P
E
S
F
N
V
L
L
K
E
I
R
S
L
G
I
N
I
E
L
E
D
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
80.95
46%
-52
- C7 -
4MEY
-
RPOB_ECOLI
C:
[8-1339]
-------
K
K
R
I
R
K
D
F
G
K
R
P
Q
V
L
D
V
P
Y
L
L
S
I
Q
L
D
S
F
Q
K
F
I
E
Q
D
P
E
G
Q
Y
G
L
E
A
A
F
R
S
V
F
P
I
Q
S
Y
S
G
N
S
E
L
Q
Y
V
S
Y
R
L
G
E
P
V
F
D
V
Q
E
C
Q
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Y
S
A
P
L
R
V
K
L
R
L
V
I
Y
E
R
E
A
P
E
G
T
---
V
K
D
I
K
E
Q
E
V
Y
M
G
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P
L
M
T
D
N
G
T
F
V
I
N
G
T
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R
V
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S
Q
L
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P
G
V
F
F
D
S
D
K
G
K
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S
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G
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Y
N
A
R
I
I
P
Y
R
G
S
W
L
D
F
E
F
D
P
K
D
N
L
F
V
R
I
D
R
R
R
K
L
P
A
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A
L
N
Y
T
T
E
Q
I
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L
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D
N
K
L
Q
M
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L
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--
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-
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P
V
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Y
I
A
G
K
V
V
A
K
D
Y
I
DESTGELICA
A
N
M
E
L
S
L
D
L
L
A
K
L
S
Q
S
G
H
K
R
I
------
E
T
L
F
T
N
D
L
D
H
G
P
Y
I
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---------
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T
L
R
V
D
P
T
N
D
R
L
S
-----
A
L
V
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Y
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M
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P
T
R
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A
A
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Y
D
L
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L
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G
S
G
I
L
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K
D
D
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L
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R
N
G
K
G
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V
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M
A
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L
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E
R
A
V
K
E
R
L
S
L
--
G
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M
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K
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D
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A
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A
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P
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L
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A
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A
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I
V
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A
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L
T
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Y
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A
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K
D
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V
Q
V
F
T
R
D
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K
D
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A
L
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M
Q
L
K
Q
A
K
K
D
L
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E
L
Q
I
L
E
A
G
L
F
S
R
I
R
A
V
L
V
A
G
---------
G
V
E
A
E
K
L
D
K
L
P
R
------
D
R
W
L
E
L
G
L
T
---
D
E
E
K
Q
N
Q
L
E
----
Q
L
A
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Q
Y
D
E
L
K
H
E
F
E
K
K
L
E
A
K
R
R
K
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Q
G
D
D
L
A
P
-
G
V
L
K
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V
K
V
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R
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D
K
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A
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V
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L
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A
A
K
G
I
G
D
K
I
N
A
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A
K
L
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A
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A
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D
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-----
T
F
S
D
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M
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L
A
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L
R
K
G
M
P
I
A
T
P
V
F
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A
K
E
A
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K
E
L
L
K
L
G
D
L
P
T
S
G
Q
I
R
L
Y
D
G
R
T
G
E
Q
F
E
R
P
V
T
V
G
Y
M
Y
M
L
K
L
N
H
L
V
D
D
K
M
H
A
R
S
T
G
S
Y
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L
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T
Q
Q
P
L
G
G
K
A
Q
F
G
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Q
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F
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V
W
A
L
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A
Y
G
A
A
Y
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L
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K
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D
D
V
N
G
R
T
K
M
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K
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I
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Q
M
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G
M
P
E
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V
L
L
K
E
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S
L
G
I
N
I
E
L
E
D
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
80.90
46%
-51
- C7 -
4MEX
1
RPOB_ECOLI
C:
[8-1339]
-------
K
K
R
I
R
K
D
F
G
K
R
P
Q
V
L
D
V
P
Y
L
L
S
I
Q
L
D
S
F
Q
K
F
I
E
Q
D
P
E
G
Q
Y
G
L
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A
A
F
R
S
V
F
P
I
Q
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Y
S
G
N
S
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L
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Y
V
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L
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V
F
D
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Q
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C
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S
A
P
L
R
V
K
L
R
L
V
I
Y
E
R
E
A
P
E
G
T
---
V
K
D
I
K
E
Q
E
V
Y
M
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P
L
M
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D
N
G
T
F
V
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T
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G
V
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F
D
S
D
K
G
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Y
N
A
R
I
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P
Y
R
G
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N
L
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R
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D
R
R
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K
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A
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A
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Y
T
T
E
Q
I
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L
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M
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-
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V
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I
A
G
K
V
V
A
K
D
Y
I
DESTGELICA
A
N
M
E
L
S
L
D
L
L
A
K
L
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Q
S
G
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I
------
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L
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T
N
D
L
D
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G
P
Y
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---------
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T
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R
V
D
P
T
N
D
R
L
S
-----
A
L
V
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M
M
R
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E
P
P
T
R
E
A
A
E
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R
Y
D
L
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A
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G
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M
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L
L
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I
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G
S
G
I
L
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K
D
D
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K
K
L
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R
N
G
K
G
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V
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M
A
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F
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V
G
L
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R
V
E
R
A
V
K
E
R
L
S
L
--
G
D
L
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M
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Q
D
M
I
N
A
K
P
I
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A
A
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A
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Y
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Y
M
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A
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A
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A
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A
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A
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G
V
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A
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R
I
V
I
K
V
N
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MYPG
E
A
G
I
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Y
N
L
T
K
Y
T
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C
I
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L
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A
G
L
F
S
R
I
R
A
V
L
V
A
G
---------
G
V
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A
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K
L
D
K
L
P
R
------
D
R
W
L
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L
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L
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---
D
E
E
K
Q
N
Q
L
E
----
Q
L
A
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Q
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D
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L
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H
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F
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K
K
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-----
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S
G
Q
I
R
L
Y
D
G
R
T
G
E
Q
F
E
R
P
V
T
V
G
Y
M
Y
M
L
K
L
N
H
L
V
D
D
K
M
H
A
R
S
T
G
S
Y
S
L
V
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
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M
E
V
W
A
L
E
A
Y
G
A
A
Y
T
L
Q
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M
L
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K
S
D
D
V
N
G
R
T
K
M
Y
K
N
I
V
D
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N
H
Q
M
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P
G
M
P
E
S
F
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V
L
L
K
E
I
R
S
L
G
I
N
I
E
L
E
D
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
80.89
46%
-54
- C7 -
4LK0
-
?
C:
[8-1339]
-------
K
K
R
I
R
K
D
F
G
K
R
P
Q
V
L
D
V
P
Y
L
L
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F
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K
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I
E
Q
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G
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V
F
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V
K
L
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---
V
K
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K
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V
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M
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A
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S
L
D
L
L
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L
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---------
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-----
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Q
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L
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A
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F
S
R
I
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A
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L
V
A
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---------
G
V
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A
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K
L
D
K
L
P
R
------
D
R
W
L
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L
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---
D
E
E
K
Q
N
Q
L
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----
Q
L
A
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Q
Y
D
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L
K
H
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F
E
K
K
L
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A
K
R
R
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D
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A
P
-
G
V
L
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-----
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M
P
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A
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A
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L
L
K
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D
L
P
T
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G
Q
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R
L
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D
G
R
T
G
E
Q
F
E
R
P
V
T
V
G
Y
M
Y
M
L
K
L
N
H
L
V
D
D
K
M
H
A
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T
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P
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G
K
A
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A
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A
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L
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I
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I
E
L
E
D
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
80.86
46%
-51
- C7 -
4YG2
1
RPOB_ECOLI
C:
[8-1339]
-------
K
K
R
I
R
K
D
F
G
K
R
P
Q
V
L
D
V
P
Y
L
L
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Q
L
D
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F
Q
K
F
I
E
Q
D
P
E
G
Q
Y
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A
A
F
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V
F
P
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Y
S
G
N
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A
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L
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K
L
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L
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---
V
K
D
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K
E
Q
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A
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L
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D
R
L
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-----
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A
A
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L
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G
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G
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A
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A
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K
E
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G
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A
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E
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L
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R
I
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A
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A
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G
V
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A
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L
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K
L
P
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------
D
R
W
L
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---
D
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K
Q
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Q
L
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----
Q
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I
R
L
Y
D
G
R
T
G
E
Q
F
E
R
P
V
T
V
G
Y
M
Y
M
L
K
L
N
H
L
V
D
D
K
M
H
A
R
S
T
G
S
Y
S
L
V
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
Y
T
L
Q
E
M
L
T
V
K
S
D
D
V
N
G
R
T
K
M
Y
K
N
I
V
D
G
N
H
Q
M
E
P
G
M
P
E
S
F
N
V
L
L
K
E
I
R
S
L
G
I
N
I
E
L
E
D
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
80.83
46%
-53
- C7 -
4YFK
2
RPOB_ECO24
I:
[8-1339]
-------
K
K
R
I
R
K
D
F
G
K
R
P
Q
V
L
D
V
P
Y
L
L
S
I
Q
L
D
S
F
Q
K
F
I
E
Q
D
P
E
G
Q
Y
G
L
E
A
A
F
R
S
V
F
P
I
Q
S
Y
S
G
N
S
E
L
Q
Y
V
S
Y
R
L
G
E
P
V
F
D
V
Q
E
C
Q
I
R
G
V
T
Y
S
A
P
L
R
V
K
L
R
L
V
I
Y
E
R
E
A
P
E
G
T
---
V
K
D
I
K
E
Q
E
V
Y
M
G
E
I
P
L
M
T
D
N
G
T
F
V
I
N
G
T
E
R
V
I
V
S
Q
L
H
R
S
P
G
V
F
F
D
S
D
K
G
K
T
H
S
S
G
K
V
L
Y
N
A
R
I
I
P
Y
R
G
S
W
L
D
F
E
F
D
P
K
D
N
L
F
V
R
I
D
R
R
R
K
L
P
A
T
I
I
L
R
A
L
N
Y
T
T
E
Q
I
L
D
L
F
F
E
K
V
I
F
E
I
R
D
N
K
L
QME
L
V
P
--
E
R
L
R
G
E
T
A
S
F
D
I
-
E
A
N
G
K
V
Y
V
E
K
G
R
R
I
T
A
R
H
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R
Q
L
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K
D
D
V
K
L
I
E
V
P
V
E
Y
I
A
G
K
V
V
A
K
D
Y
I
DESTGELICA
A
N
M
E
L
S
L
D
L
L
A
K
L
S
Q
S
G
H
K
R
I
------
E
T
L
F
T
N
D
L
D
H
G
P
Y
I
S
---------
E
T
L
R
V
D
P
T
N
D
R
L
S
-----
A
L
V
E
I
Y
R
M
M
R
P
G
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P
T
R
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A
A
E
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L
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F
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D
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Y
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L
S
A
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G
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M
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F
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L
L
R
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G
S
G
I
L
S
K
D
D
I
I
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V
M
K
K
L
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D
I
R
N
G
K
G
E
V
D
D
I
D
H
L
G
N
R
R
I
R
S
V
G
E
M
A
E
N
Q
F
R
V
G
L
V
R
V
E
R
A
V
K
E
R
L
S
L
--
G
D
L
D
T
L
M
P
Q
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M
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N
A
K
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I
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A
A
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N
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D
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F
V
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C
R
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S
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F
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R
D
Q
V
D
Y
M
D
V
S
T
Q
Q
V
V
S
V
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A
S
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
A
N
M
Q
R
Q
A
V
P
T
L
R
A
D
K
P
L
V
G
T
G
M
E
R
A
V
A
V
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S
G
V
T
A
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A
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R
G
G
V
V
Q
Y
V
D
A
S
R
I
V
I
K
V
N
E
D
E
MYPG
E
A
G
I
D
I
Y
N
L
T
K
Y
T
R
S
N
Q
N
T
C
I
N
Q
M
P
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L
G
E
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G
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V
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A
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P
S
T
D
L
G
E
L
A
L
G
Q
N
M
R
V
A
F
M
P
W
N
G
Y
N
F
E
D
S
I
L
V
S
E
R
V
V
Q
E
D
R
F
T
T
I
H
I
Q
E
L
A
C
V
S
R
D
T
K
L
G
P
E
E
I
T
A
D
I
P
N
V
G
E
A
A
L
S
K
L
D
E
S
G
I
V
Y
I
G
A
E
V
T
G
G
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I
L
V
G
K
V
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K
G
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L
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P
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A
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K
A
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V
K
D
S
S
L
R
V
P
N
G
V
S
G
T
V
I
D
V
Q
V
F
T
R
D
G
V
E
K
D
K
R
A
L
E
I
E
E
M
Q
L
K
Q
A
K
K
D
L
S
E
E
L
Q
I
L
E
A
G
L
F
S
R
I
R
A
V
L
V
A
G
---------
G
V
E
A
E
K
L
D
K
L
P
R
------
D
R
W
L
E
L
G
L
T
---
D
E
E
K
Q
N
Q
L
E
----
Q
L
A
E
Q
Y
D
E
L
K
H
E
F
E
K
K
L
E
AKRRK
I
T
Q
G
D
D
L
A
P
-
G
V
L
K
I
V
K
V
Y
L
A
V
K
R
R
I
Q
P
G
D
K
M
A
G
R
H
G
N
K
G
V
I
S
K
I
N
P
I
E
D
M
P
Y
D
E
N
G
T
P
V
D
I
V
L
N
P
L
G
V
P
S
R
M
N
I
G
Q
I
L
E
T
H
L
G
M
A
A
K
G
I
G
D
K
I
N
A
M
L
K
-
Q
Q
Q
E
V
A
K
LR
E
F
I
Q
R
A
Y
D
L
G
A
D
V
R
Q
K
V
D
L
S
-----
T
F
S
D
E
E
V
M
R
L
A
E
N
L
R
K
G
M
P
I
A
T
P
V
F
D
G
A
K
E
A
E
I
K
E
L
L
K
L
G
D
L
P
T
S
G
Q
I
R
L
Y
D
G
R
T
G
E
Q
F
E
R
P
V
T
V
G
Y
M
Y
M
L
K
L
N
H
L
V
D
D
K
M
H
A
R
S
T
G
S
Y
S
L
V
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
Y
T
L
Q
E
M
L
T
V
K
S
D
D
V
N
G
R
T
K
M
Y
K
N
I
V
D
G
N
H
Q
M
E
P
G
M
P
E
S
F
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V
L
L
K
E
I
R
S
L
G
I
N
I
E
L
E
D
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
80.79
46%
-53
- C7 -
4XSY
1
?
I:
[8-1339]
-------
K
K
R
I
R
K
D
F
G
K
R
P
Q
V
L
D
V
P
Y
L
L
S
I
Q
L
D
S
F
Q
K
F
I
E
Q
D
P
E
G
Q
Y
G
L
E
A
A
F
R
S
V
F
P
I
Q
S
Y
S
G
N
S
E
L
Q
Y
V
S
Y
R
L
G
E
P
V
F
D
V
Q
E
C
Q
I
R
G
V
T
Y
S
A
P
L
R
V
K
L
R
L
V
I
Y
E
R
E
A
P
E
G
T
---
V
K
D
I
K
E
Q
E
V
Y
M
G
E
I
P
L
M
T
D
N
G
T
F
V
I
N
G
T
E
R
V
I
V
S
Q
L
H
R
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P
G
V
F
F
D
S
D
K
G
K
T
H
S
S
G
K
V
L
Y
N
A
R
I
I
P
Y
R
G
S
W
L
D
F
E
F
D
P
K
D
N
L
F
V
R
I
D
R
R
R
K
L
P
A
T
I
I
L
R
A
L
N
Y
T
T
E
Q
I
L
D
L
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F
E
K
V
I
F
E
I
R
D
N
K
L
QME
L
V
P
--
E
R
L
R
G
E
T
A
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F
D
I
-
E
A
N
G
K
V
Y
V
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K
G
R
R
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A
R
H
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Q
L
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V
K
L
I
E
V
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V
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Y
I
A
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K
V
V
A
K
D
Y
I
DESTGELICA
A
N
M
E
L
S
L
D
L
L
A
K
L
S
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S
G
H
K
R
I
------
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T
L
F
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L
D
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G
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Y
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---------
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T
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R
V
D
P
T
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D
R
L
S
-----
A
L
V
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I
Y
R
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M
R
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G
E
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P
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E
A
A
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L
S
A
V
G
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M
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L
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S
G
I
L
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D
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K
K
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N
G
K
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A
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K
E
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--
G
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N
A
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G
V
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A
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I
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K
V
N
E
D
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MYPG
E
A
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I
Y
N
L
T
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Y
T
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L
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A
G
L
F
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R
I
R
A
V
L
V
A
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---------
G
V
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A
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K
L
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K
L
P
R
------
D
R
W
L
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L
G
L
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---
D
E
E
K
Q
N
Q
L
E
----
Q
L
A
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Q
Y
D
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L
K
H
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F
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K
K
L
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AKRRK
I
T
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T
V
G
Y
M
Y
M
L
K
L
N
H
L
V
D
D
K
M
H
A
R
S
T
G
S
Y
S
L
V
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
Y
T
L
Q
E
M
L
T
V
K
S
D
D
V
N
G
R
T
K
M
Y
K
N
I
V
D
G
N
H
Q
M
E
P
G
M
P
E
S
F
N
V
L
L
K
E
I
R
S
L
G
I
N
I
E
L
E
D
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
PsiBlast_CBE
80.76
46%
-55
- C7 -
4XSX
1
?
C:
[8-1339]
-------
K
K
R
I
R
K
D
F
G
K
R
P
Q
V
L
D
V
P
Y
L
L
S
I
Q
L
D
S
F
Q
K
F
I
E
Q
D
P
E
G
Q
Y
G
L
E
A
A
F
R
S
V
F
P
I
Q
S
Y
S
G
N
S
E
L
Q
Y
V
S
Y
R
L
G
E
P
V
F
D
V
Q
E
C
Q
I
R
G
V
T
Y
S
A
P
L
R
V
K
L
R
L
V
I
Y
E
R
E
A
P
E
G
T
---
V
K
D
I
K
E
Q
E
V
Y
M
G
E
I
P
L
M
T
D
N
G
T
F
V
I
N
G
T
E
R
V
I
V
S
Q
L
H
R
S
P
G
V
F
F
D
S
D
K
G
K
T
H
S
S
G
K
V
L
Y
N
A
R
I
I
P
Y
R
G
S
W
L
D
F
E
F
D
P
K
D
N
L
F
V
R
I
D
R
R
R
K
L
P
A
T
I
I
L
R
A
L
N
Y
T
T
E
Q
I
L
D
L
F
F
E
K
V
I
F
E
I
R
D
N
K
L
Q
M
E
L
V
P
--
E
R
L
R
G
E
T
A
S
F
D
I
-
E
A
N
G
K
V
Y
V
E
K
G
R
R
I
T
A
R
H
I
R
Q
L
E
K
D
D
V
K
L
I
E
V
P
V
E
Y
I
A
G
K
V
V
A
K
D
Y
I
D
ESTGELICA
A
N
M
E
L
S
L
D
L
L
A
K
L
S
Q
S
G
H
K
R
I
------
E
T
L
F
T
N
D
L
D
H
G
P
Y
I
S
---------
E
T
L
R
V
D
P
T
N
D
R
L
S
-----
A
L
V
E
I
Y
R
M
M
R
P
G
E
P
P
T
R
E
A
A
E
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L
F
E
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L
F
F
S
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D
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Y
D
L
S
A
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G
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M
K
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L
L
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G
S
G
I
L
S
K
D
D
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I
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V
M
K
K
L
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D
I
R
N
G
K
G
E
V
D
D
I
D
H
L
G
N
R
R
I
R
S
V
G
E
M
A
E
N
Q
F
R
V
G
L
V
R
V
E
R
A
V
K
E
R
L
S
L
--
G
D
L
D
T
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M
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Q
D
M
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N
A
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L
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G
L
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A
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N
Y
V
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A
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N
L
D
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E
G
H
F
V
E
D
L
V
T
C
R
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K
G
E
S
S
L
F
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R
D
Q
V
D
Y
M
D
V
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T
Q
Q
V
V
S
V
G
A
S
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
A
N
M
Q
R
Q
A
V
P
T
L
R
A
D
K
P
L
V
G
T
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M
E
R
A
V
A
V
D
S
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V
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A
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A
K
R
G
G
V
V
Q
Y
V
D
A
S
R
I
V
I
K
V
N
E
D
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MYPG
E
A
G
I
D
I
Y
N
L
T
K
Y
T
R
S
N
Q
N
T
C
I
N
Q
M
P
C
V
S
L
G
E
P
V
E
R
G
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A
D
G
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T
D
L
G
E
L
A
L
G
Q
N
M
R
V
A
F
M
P
W
N
G
Y
N
F
E
D
S
I
L
V
S
E
R
V
V
Q
E
D
R
F
T
T
I
H
I
Q
E
L
A
C
V
S
R
D
T
K
L
G
P
E
E
I
T
A
D
I
P
N
V
G
E
A
A
L
S
K
L
D
E
S
G
I
V
Y
I
G
A
E
V
T
G
G
D
I
L
V
G
K
V
T
P
K
G
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T
Q
L
T
P
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E
K
L
L
R
A
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G
E
K
A
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V
K
D
S
S
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R
V
P
N
G
V
S
G
T
V
I
D
V
Q
V
F
T
R
D
G
V
E
K
D
K
R
A
L
E
I
E
E
M
Q
L
K
Q
A
K
K
D
L
S
E
E
L
Q
I
L
E
A
G
L
F
S
R
I
R
A
V
L
V
A
G
---------
G
V
E
A
E
K
L
D
K
L
P
R
------
D
R
W
L
E
L
G
L
T
---
D
E
E
K
Q
N
Q
L
E
----
Q
L
A
E
Q
Y
D
E
L
K
H
E
F
E
K
K
L
E
A
K
R
R
K
I
T
Q
G
D
D
L
A
P
-
G
V
L
K
I
V
K
V
Y
L
A
V
K
R
R
I
Q
P
G
D
K
M
A
G
R
H
G
N
K
G
V
I
S
K
I
N
P
I
E
D
M
P
Y
D
E
N
G
T
P
V
D
I
V
L
N
P
L
G
V
P
S
R
M
N
I
G
Q
I
L
E
T
H
L
G
M
A
A
K
G
I
G
D
K
I
N
A
M
L
K
-
Q
Q
Q
E
V
A
K
L
R
E
F
I
Q
R
A
Y
D
L
G
A
D
V
R
Q
K
V
D
L
S
-----
T
F
S
D
E
E
V
M
R
L
A
E
N
L
R
K
G
M
P
I
A
T
P
V
F
D
G
A
K
E
A
E
I
K
E
L
L
K
L
G
D
L
P
T
S
G
Q
I
R
L
Y
D
G
R
T
G
E
Q
F
E
R
P
V
T
V
G
Y
M
Y
M
L
K
L
N
H
L
V
D
D
K
M
H
A
R
S
T
G
S
Y
S
L
V
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
Y
T
L
Q
E
M
L
T
V
K
S
D
D
V
N
G
R
T
K
M
Y
K
N
I
V
D
G
N
H
Q
M
E
P
G
M
P
E
S
F
N
V
L
L
K
E
I
R
S
L
G
I
N
I
E
L
E
D
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
PsiBlast_CBE
80.76
46%
-56
- C7 -
4XSX
1
?
I:
[8-1339]
-------
K
K
R
I
R
K
D
F
G
K
R
P
Q
V
L
D
V
P
Y
L
L
S
I
Q
L
D
S
F
Q
K
F
I
E
Q
D
P
E
G
Q
Y
G
L
E
A
A
F
R
S
V
F
P
I
Q
S
Y
S
G
N
S
E
L
Q
Y
V
S
Y
R
L
G
E
P
V
F
D
V
Q
E
C
Q
I
R
G
V
T
Y
S
A
P
L
R
V
K
L
R
L
V
I
Y
E
R
E
A
P
E
G
T
---
V
K
D
I
K
E
Q
E
V
Y
M
G
E
I
P
L
M
T
D
N
G
T
F
V
I
N
G
T
E
R
V
I
V
S
Q
L
H
R
S
P
G
V
F
F
D
S
D
K
G
K
T
H
S
S
G
K
V
L
Y
N
A
R
I
I
P
Y
R
G
S
W
L
D
F
E
F
D
P
K
D
N
L
F
V
R
I
D
R
R
R
K
L
P
A
T
I
I
L
R
A
L
N
Y
T
T
E
Q
I
L
D
L
F
F
E
K
V
I
F
E
I
R
D
N
K
L
QME
L
V
P
--
E
R
L
R
G
E
T
A
S
F
D
I
-
E
A
N
G
K
V
Y
V
E
K
G
R
R
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T
A
R
H
I
R
Q
L
E
K
D
D
V
K
L
I
E
V
P
V
E
Y
I
A
G
K
V
V
A
K
D
Y
I
DESTGELICA
A
N
M
E
L
S
L
D
L
L
A
K
L
S
Q
S
G
H
K
R
I
------
E
T
L
F
T
N
D
L
D
H
G
P
Y
I
S
---------
E
T
L
R
V
D
P
T
N
D
R
L
S
-----
A
L
V
E
I
Y
R
M
M
R
P
G
E
P
P
T
R
E
A
A
E
S
L
F
E
N
L
F
F
S
E
D
R
Y
D
L
S
A
V
G
R
M
K
F
N
R
S
L
L
R
E
E
I
E
G
S
G
I
L
S
K
D
D
I
I
D
V
M
K
K
L
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D
I
R
N
G
K
G
E
V
D
D
I
D
H
L
G
N
R
R
I
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S
V
G
E
M
A
E
N
Q
F
R
V
G
L
V
R
V
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R
A
V
K
E
R
L
S
L
--
G
D
L
D
T
L
M
P
Q
D
M
I
N
A
K
P
I
S
A
A
V
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Q
N
N
P
L
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A
L
G
P
G
G
L
T
R
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V
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P
T
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Y
G
R
V
C
P
I
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G
L
I
N
S
L
S
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Y
A
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G
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V
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N
Y
V
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A
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A
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D
Y
M
D
V
S
T
Q
Q
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A
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I
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L
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D
D
A
N
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A
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A
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A
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A
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A
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S
G
V
T
A
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A
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R
G
G
V
V
Q
Y
V
D
A
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R
I
V
I
K
V
N
E
D
E
MYPG
E
A
G
I
D
I
Y
N
L
T
K
Y
T
R
S
N
Q
N
T
C
I
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L
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P
V
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G
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D
L
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E
L
A
L
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Q
N
M
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I
Q
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L
A
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A
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D
V
K
D
S
S
L
R
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N
G
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V
Q
V
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T
R
D
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V
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K
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A
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E
M
Q
L
K
Q
A
K
K
D
L
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E
E
L
Q
I
L
E
A
G
L
F
S
R
I
R
A
V
L
V
A
G
---------
G
V
E
A
E
K
L
D
K
L
P
R
------
D
R
W
L
E
L
G
L
T
---
D
E
E
K
Q
N
Q
L
E
----
Q
L
A
E
Q
Y
D
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L
K
H
E
F
E
K
K
L
E
AKRRK
I
T
Q
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H
L
V
D
D
K
M
H
A
R
S
T
G
S
Y
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L
V
T
Q
Q
P
L
G
G
K
A
Q
F
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E
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W
A
L
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A
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K
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D
D
V
N
G
R
T
K
M
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L
K
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S
L
G
I
N
I
E
L
E
D
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
80.67
46%
-54
- C7 -
4LJZ
-
?
C:
[8-1339]
-------
K
K
R
I
R
K
D
F
G
K
R
P
Q
V
L
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V
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Y
L
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---
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A
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L
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---------
G
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------
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---
D
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K
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Q
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----
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F
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Y
M
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M
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N
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I
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L
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D
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
80.66
46%
-53
- C7 -
4LLG
-
?
C:
[8-1339]
-------
K
K
R
I
R
K
D
F
G
K
R
P
Q
V
L
D
V
P
Y
L
L
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A
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D
K
M
H
A
R
S
T
G
S
Y
S
L
V
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
Y
T
L
Q
E
M
L
T
V
K
S
D
D
V
N
G
R
T
K
M
Y
K
N
I
V
D
G
N
H
Q
M
E
P
G
M
P
E
S
F
N
V
L
L
K
E
I
R
S
L
G
I
N
I
E
L
E
D
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
80.59
46%
-51
- C7 -
4ZH2
1
?
C:
[8-1339]
-------
K
K
R
I
R
K
D
F
G
K
R
P
Q
V
L
D
V
P
Y
L
L
S
I
Q
L
D
S
F
Q
K
F
I
E
Q
D
P
E
G
Q
Y
G
L
E
A
A
F
R
S
V
F
P
I
Q
S
Y
S
G
N
S
E
L
Q
Y
V
S
Y
R
L
G
E
P
V
F
D
V
Q
E
C
Q
I
R
G
V
T
Y
S
A
P
L
R
V
K
L
R
L
V
I
Y
E
R
E
A
P
E
G
T
---
V
K
D
I
K
E
Q
E
V
Y
M
G
E
I
P
L
M
T
D
N
G
T
F
V
I
N
G
T
E
R
V
I
V
S
Q
L
H
R
S
P
G
V
F
F
D
S
D
K
G
K
T
H
S
S
G
K
V
L
Y
N
A
R
I
I
P
Y
R
G
S
W
L
D
F
E
F
D
P
K
D
N
L
F
V
R
I
D
R
R
R
K
L
P
A
T
I
I
L
R
A
L
N
Y
T
T
E
Q
I
L
D
L
F
F
E
K
V
I
F
E
I
R
D
N
K
L
Q
M
E
L
V
P
--
E
R
L
R
G
E
T
A
S
F
D
I
-
E
A
N
G
K
V
Y
V
E
K
G
R
R
I
T
A
R
H
I
R
Q
L
E
K
D
D
V
K
L
I
E
V
P
V
E
Y
I
A
G
K
V
V
A
K
D
Y
I
D
ESTGELICA
A
N
M
E
L
S
L
D
L
L
A
K
L
S
Q
S
G
H
K
R
I
------
E
T
L
F
T
N
D
L
D
H
G
P
Y
I
S
---------
E
T
L
R
V
D
P
T
N
D
R
L
S
-----
A
L
V
E
I
Y
R
M
M
R
P
G
E
P
P
T
R
E
A
A
E
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L
F
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L
F
F
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Y
D
L
S
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G
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M
K
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L
L
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G
S
G
I
L
S
K
D
D
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V
M
K
K
L
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D
I
R
N
G
K
G
E
V
D
D
I
D
H
L
G
N
R
R
I
R
S
V
G
E
M
A
E
N
Q
F
R
V
G
L
V
R
V
E
R
A
V
K
E
R
L
S
L
--
G
D
L
D
T
L
M
P
Q
D
M
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N
A
K
P
I
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A
A
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K
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Q
L
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L
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A
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N
Y
V
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A
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S
N
L
D
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E
G
H
F
V
E
D
L
V
T
C
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S
K
G
E
S
S
L
F
S
R
D
Q
V
D
Y
M
D
V
S
T
Q
Q
V
V
S
V
G
A
S
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
A
N
M
Q
R
Q
A
V
P
T
L
R
A
D
K
P
L
V
G
T
G
M
E
R
A
V
A
V
D
S
G
V
T
A
V
A
K
R
G
G
V
V
Q
Y
V
D
A
S
R
I
V
I
K
V
N
E
D
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MYPG
E
A
G
I
D
I
Y
N
L
T
K
Y
T
R
S
N
Q
N
T
C
I
N
Q
M
P
C
V
S
L
G
E
P
V
E
R
G
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L
A
D
G
P
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T
D
L
G
E
L
A
L
G
Q
N
M
R
V
A
F
M
P
W
N
G
Y
N
F
E
D
S
I
L
V
S
E
R
V
V
Q
E
D
R
F
T
T
I
H
I
Q
E
L
A
C
V
S
R
D
T
K
L
G
P
E
E
I
T
A
D
I
P
N
V
G
E
A
A
L
S
K
L
D
E
S
G
I
V
Y
I
G
A
E
V
T
G
G
D
I
L
V
G
K
V
T
P
K
G
E
T
Q
L
T
P
E
E
K
L
L
R
A
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F
G
E
K
A
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D
V
K
D
S
S
L
R
V
P
N
G
V
S
G
T
V
I
D
V
Q
V
F
T
R
D
G
V
E
K
D
K
R
A
L
E
I
E
E
M
Q
L
K
Q
A
K
K
D
L
S
E
E
L
Q
I
L
E
A
G
L
F
S
R
I
R
A
V
L
V
A
G
---------
G
V
E
A
E
K
L
D
K
L
P
R
------
D
R
W
L
E
L
G
L
T
---
D
E
E
K
Q
N
Q
L
E
----
Q
L
A
E
Q
Y
D
E
L
K
H
E
F
E
K
K
L
E
A
K
R
R
K
I
T
Q
G
D
D
L
A
P
-
G
V
L
K
I
V
K
V
Y
L
A
V
K
R
R
I
Q
P
G
D
K
M
A
G
R
H
G
N
K
G
V
I
S
K
I
N
P
I
E
D
M
P
Y
D
E
N
G
T
P
V
D
I
V
L
N
P
L
G
V
P
S
R
M
N
I
G
Q
I
L
E
T
H
L
G
M
A
A
K
G
I
G
D
K
I
N
A
M
L
K
-
Q
Q
Q
E
V
A
K
L
R
E
F
I
Q
R
A
Y
D
L
G
A
D
V
R
Q
K
V
D
L
S
-----
T
F
S
D
E
E
V
M
R
L
A
E
N
L
R
K
G
M
P
I
A
T
P
V
F
D
G
A
K
E
A
E
I
K
E
L
L
K
L
G
D
L
P
T
S
G
Q
I
R
L
Y
D
G
R
T
G
E
Q
F
E
R
P
V
T
V
G
Y
M
Y
M
L
K
L
N
H
L
V
D
D
K
M
H
A
R
S
T
G
S
Y
S
L
V
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
Y
T
L
Q
E
M
L
T
V
K
S
D
D
V
N
G
R
T
K
M
Y
K
N
I
V
D
G
N
H
Q
M
E
P
G
M
P
E
S
F
N
V
L
L
K
E
I
R
S
L
G
I
N
I
E
L
E
D
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
80.47
46%
-52
- C7 -
4ZH3
1
?
I:
[8-1339]
-------
K
K
R
I
R
K
D
F
G
K
R
P
Q
V
L
D
V
P
Y
L
L
S
I
Q
L
D
S
F
Q
K
F
I
E
Q
D
P
E
G
Q
Y
G
L
E
A
A
F
R
S
V
F
P
I
Q
S
Y
S
G
N
S
E
L
Q
Y
V
S
Y
R
L
G
E
P
V
F
D
V
Q
E
C
Q
I
R
G
V
T
Y
S
A
P
L
R
V
K
L
R
L
V
I
Y
E
R
E
A
P
E
G
T
---
V
K
D
I
K
E
Q
E
V
Y
M
G
E
I
P
L
M
T
D
N
G
T
F
V
I
N
G
T
E
R
V
I
V
S
Q
L
H
R
S
P
G
V
F
F
D
S
D
K
G
K
T
H
S
S
G
K
V
L
Y
N
A
R
I
I
P
Y
R
G
S
W
L
D
F
E
F
D
P
K
D
N
L
F
V
R
I
D
R
R
R
K
L
P
A
T
I
I
L
R
A
L
N
Y
T
T
E
Q
I
L
D
L
F
F
E
K
V
I
F
E
I
R
D
N
K
L
QME
L
V
P
--
E
R
L
R
G
E
T
A
S
F
D
I
-
E
A
N
G
K
V
Y
V
E
K
G
R
R
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T
A
R
H
I
R
Q
L
E
K
D
D
V
K
L
I
E
V
P
V
E
Y
I
A
G
K
V
V
A
K
D
Y
I
DESTGELICA
A
N
M
E
L
S
L
D
L
L
A
K
L
S
Q
S
G
H
K
R
I
------
E
T
L
F
T
N
D
L
D
H
G
P
Y
I
S
---------
E
T
L
R
V
D
P
T
N
D
R
L
S
-----
A
L
V
E
I
Y
R
M
M
R
P
G
E
P
P
T
R
E
A
A
E
S
L
F
E
N
L
F
F
S
E
D
R
Y
D
L
S
A
V
G
R
M
K
F
N
R
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L
L
R
E
E
I
E
G
S
G
I
L
S
K
D
D
I
I
D
V
M
K
K
L
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D
I
R
N
G
K
G
E
V
D
D
I
D
H
L
G
N
R
R
I
R
S
V
G
E
M
A
E
N
Q
F
R
V
G
L
V
R
V
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R
A
V
K
E
R
L
S
L
--
G
D
L
D
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M
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Q
D
M
I
N
A
K
P
I
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A
A
V
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Q
N
N
P
L
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A
L
G
P
G
G
L
T
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P
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Y
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R
V
C
P
I
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L
I
N
S
L
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Y
A
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G
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V
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N
Y
V
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A
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A
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C
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D
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M
D
V
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T
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Q
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D
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A
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A
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A
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A
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A
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G
V
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A
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R
G
G
V
V
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Y
V
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A
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R
I
V
I
K
V
N
E
D
E
MYPG
E
A
G
I
D
I
Y
N
L
T
K
Y
T
R
S
N
Q
N
T
C
I
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L
A
L
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Q
N
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Q
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A
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A
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K
D
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S
L
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V
Q
V
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T
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D
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V
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K
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K
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A
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E
E
M
Q
L
K
Q
A
K
K
D
L
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E
E
L
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I
L
E
A
G
L
F
S
R
I
R
A
V
L
V
A
G
---------
G
V
E
A
E
K
L
D
K
L
P
R
------
D
R
W
L
E
L
G
L
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---
D
E
E
K
Q
N
Q
L
E
----
Q
L
A
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Q
Y
D
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L
K
H
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F
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K
K
L
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AKRRK
I
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S
L
V
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
Y
T
L
Q
E
M
L
T
V
K
S
D
D
V
N
G
R
T
K
M
Y
K
N
I
V
D
G
N
H
Q
M
E
P
G
M
P
E
S
F
N
V
L
L
K
E
I
R
S
L
G
I
N
I
E
L
E
D
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
80.44
46%
-53
- C7 -
4JKR
2
?
C:
[8-1339]
-------
K
K
R
I
R
K
D
F
G
K
R
P
Q
V
L
D
V
P
Y
L
L
S
I
Q
L
D
S
F
Q
K
F
I
E
Q
D
P
E
G
Q
Y
G
L
E
A
A
F
R
S
V
F
P
I
Q
S
Y
S
G
N
S
E
L
Q
Y
V
S
Y
R
L
G
E
P
V
F
D
V
Q
E
C
Q
I
R
G
V
T
Y
S
A
P
L
R
V
K
L
R
L
V
I
Y
E
R
E
A
P
E
G
T
---
V
K
D
I
K
E
Q
E
V
Y
M
G
E
I
P
L
M
T
D
N
G
T
F
V
I
N
G
T
E
R
V
I
V
S
Q
L
H
R
S
P
G
V
F
F
D
S
D
K
G
K
T
H
S
S
G
K
V
L
Y
N
A
R
I
I
P
Y
R
G
S
W
L
D
F
E
F
D
P
K
D
N
L
F
V
R
I
D
R
R
R
K
L
P
A
T
I
I
L
R
A
L
N
Y
T
T
E
Q
I
L
D
L
F
F
E
K
V
I
F
E
I
R
D
N
K
L
QME
L
V
P
--
E
R
L
R
G
E
T
A
S
F
D
I
-
E
A
N
G
K
V
Y
V
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K
G
R
R
I
T
A
R
H
I
R
Q
L
E
K
D
D
V
K
L
I
E
V
P
V
E
Y
I
A
G
K
V
V
A
K
D
Y
I
DESTGELICA
A
N
M
E
L
S
L
D
L
L
A
K
L
S
Q
S
G
H
K
R
I
------
E
T
L
F
T
N
D
L
D
H
G
P
Y
I
S
---------
E
T
L
R
V
D
P
T
N
D
R
L
S
-----
A
L
V
E
I
Y
R
M
M
R
P
G
E
P
P
T
R
E
A
A
E
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L
F
E
N
L
F
F
S
E
D
R
Y
D
L
S
A
V
G
R
M
K
F
N
R
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L
L
R
E
E
I
E
G
S
G
I
L
S
K
D
D
I
I
D
V
M
K
K
L
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D
I
R
N
G
K
G
E
V
D
D
I
D
H
L
G
N
R
R
I
R
S
V
G
E
M
A
E
N
Q
F
R
V
G
L
V
R
V
E
R
A
V
K
E
R
L
S
L
--
G
D
L
D
T
L
M
P
Q
D
M
I
N
A
K
P
I
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A
A
V
K
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F
F
G
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N
P
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L
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V
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A
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A
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N
L
D
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E
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H
F
V
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D
L
V
T
C
R
S
K
G
E
S
S
L
F
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R
D
Q
V
D
Y
M
D
V
S
T
Q
Q
V
V
S
V
G
A
S
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
A
N
M
Q
R
Q
A
V
P
T
L
R
A
D
K
P
L
V
G
T
G
M
E
R
A
V
A
V
D
S
G
V
T
A
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A
K
R
G
G
V
V
Q
Y
V
D
A
S
R
I
V
I
K
V
N
E
D
E
MYPG
E
A
G
I
D
I
Y
N
L
T
K
Y
T
R
S
N
Q
N
T
C
I
N
Q
M
P
C
V
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L
G
E
P
V
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R
G
D
V
L
A
D
G
P
S
T
D
L
G
E
L
A
L
G
Q
N
M
R
V
A
F
M
P
W
N
G
Y
N
F
E
D
S
I
L
V
S
E
R
V
V
Q
E
D
R
F
T
T
I
H
I
Q
E
L
A
C
V
S
R
D
T
K
L
G
P
E
E
I
T
A
D
I
P
N
V
G
E
A
A
L
S
K
L
D
E
S
G
I
V
Y
I
G
A
E
V
T
G
G
D
I
L
V
G
K
V
T
P
K
G
E
T
Q
L
T
P
E
E
K
L
L
R
A
I
F
G
E
K
A
S
D
V
K
D
S
S
L
R
V
P
N
G
V
S
G
T
V
I
D
V
Q
V
F
T
R
D
G
V
E
K
D
K
R
A
L
E
I
E
E
M
Q
L
K
Q
A
K
K
D
L
S
E
E
L
Q
I
L
E
A
G
L
F
S
R
I
R
A
V
L
V
A
G
---------
G
V
E
A
E
K
L
D
K
L
P
R
------
D
R
W
L
E
L
G
L
T
---
D
E
E
K
Q
N
Q
L
E
----
Q
L
A
E
Q
Y
D
E
L
K
H
E
F
E
K
K
L
E
AKRRK
I
T
Q
G
D
D
L
A
P
-
G
V
L
K
I
V
K
V
Y
L
A
V
K
R
R
I
Q
P
G
D
K
M
A
G
R
H
G
N
K
G
V
I
S
K
I
N
P
I
E
D
M
P
Y
D
E
N
G
T
P
V
D
I
V
L
N
P
L
G
V
P
S
R
M
N
I
G
Q
I
L
E
T
H
L
G
M
A
A
K
G
I
G
D
K
I
N
A
M
L
K
-
Q
Q
Q
E
V
A
K
LR
E
F
I
Q
R
A
Y
D
L
G
A
D
V
R
Q
K
V
D
L
S
-----
T
F
S
D
E
E
V
M
R
L
A
E
N
L
R
K
G
M
P
I
A
T
P
V
F
D
G
A
K
E
A
E
I
K
E
L
L
K
L
G
D
L
P
T
S
G
Q
I
R
L
Y
D
G
R
T
G
E
Q
F
E
R
P
V
T
V
G
Y
M
Y
M
L
K
L
N
H
L
V
D
D
K
M
H
A
R
S
T
G
S
Y
S
L
V
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
Y
T
L
Q
E
M
L
T
V
K
S
D
D
V
N
G
R
T
K
M
Y
K
N
I
V
D
G
N
H
Q
M
E
P
G
M
P
E
S
F
N
V
L
L
K
E
I
R
S
L
G
I
N
I
E
L
E
D
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
80.42
46%
-51
- C7 -
4ZH4
1
?
I:
[8-1339]
-------
K
K
R
I
R
K
D
F
G
K
R
P
Q
V
L
D
V
P
Y
L
L
S
I
Q
L
D
S
F
Q
K
F
I
E
Q
D
P
E
G
Q
Y
G
L
E
A
A
F
R
S
V
F
P
I
Q
S
Y
S
G
N
S
E
L
Q
Y
V
S
Y
R
L
G
E
P
V
F
D
V
Q
E
C
Q
I
R
G
V
T
Y
S
A
P
L
R
V
K
L
R
L
V
I
Y
E
R
E
A
P
E
G
T
---
V
K
D
I
K
E
Q
E
V
Y
M
G
E
I
P
L
M
T
D
N
G
T
F
V
I
N
G
T
E
R
V
I
V
S
Q
L
H
R
S
P
G
V
F
F
D
S
D
K
G
K
T
H
S
S
G
K
V
L
Y
N
A
R
I
I
P
Y
R
G
S
W
L
D
F
E
F
D
P
K
D
N
L
F
V
R
I
D
R
R
R
K
L
P
A
T
I
I
L
R
A
L
N
Y
T
T
E
Q
I
L
D
L
F
F
E
K
V
I
F
E
I
R
D
N
K
L
QME
L
V
P
--
E
R
L
R
G
E
T
A
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F
D
I
-
E
A
N
G
K
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Y
V
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K
G
R
R
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A
R
H
I
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Q
L
E
K
D
D
V
K
L
I
E
V
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V
E
Y
I
A
G
K
V
V
A
K
D
Y
I
DESTGELICA
A
N
M
E
L
S
L
D
L
L
A
K
L
S
Q
S
G
H
K
R
I
------
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T
L
F
T
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D
L
D
H
G
P
Y
I
S
---------
E
T
L
R
V
D
P
T
N
D
R
L
S
-----
A
L
V
E
I
Y
R
M
M
R
P
G
E
P
P
T
R
E
A
A
E
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L
F
E
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L
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F
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E
D
R
Y
D
L
S
A
V
G
R
M
K
F
N
R
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L
L
R
E
E
I
E
G
S
G
I
L
S
K
D
D
I
I
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V
M
K
K
L
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D
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R
N
G
K
G
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D
D
I
D
H
L
G
N
R
R
I
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S
V
G
E
M
A
E
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Q
F
R
V
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L
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R
V
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A
V
K
E
R
L
S
L
--
G
D
L
D
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M
P
Q
D
M
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N
A
K
P
I
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A
A
V
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A
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L
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M
D
V
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Q
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A
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F
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D
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A
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A
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A
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A
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A
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V
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A
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A
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R
G
G
V
V
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Y
V
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A
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R
I
V
I
K
V
N
E
D
E
MYPG
E
A
G
I
D
I
Y
N
L
T
K
Y
T
R
S
N
Q
N
T
C
I
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L
A
L
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Q
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A
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K
D
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L
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A
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M
Q
L
K
Q
A
K
K
D
L
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E
E
L
Q
I
L
E
A
G
L
F
S
R
I
R
A
V
L
V
A
G
---------
G
V
E
A
E
K
L
D
K
L
P
R
------
D
R
W
L
E
L
G
L
T
---
D
E
E
K
Q
N
Q
L
E
----
Q
L
A
E
Q
Y
D
E
L
K
H
E
F
E
K
K
L
E
AKRRK
I
T
Q
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G
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-----
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A
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L
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L
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F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
Y
T
L
Q
E
M
L
T
V
K
S
D
D
V
N
G
R
T
K
M
Y
K
N
I
V
D
G
N
H
Q
M
E
P
G
M
P
E
S
F
N
V
L
L
K
E
I
R
S
L
G
I
N
I
E
L
E
D
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
80.09
46%
-50
- C7 -
4YLP
1
RPOB_ECOLI
I:
[8-1339]
-------
K
K
R
I
R
K
D
F
G
K
R
P
Q
V
L
D
V
P
Y
L
L
S
I
Q
L
D
S
F
Q
K
F
I
E
Q
D
P
E
G
Q
Y
G
L
E
A
A
F
R
S
V
F
P
I
Q
S
Y
S
G
N
S
E
L
Q
Y
V
S
Y
R
L
G
E
P
V
F
D
V
Q
E
C
Q
I
R
G
V
T
Y
S
A
P
L
R
V
K
L
R
L
V
I
Y
E
R
E
A
P
E
G
T
---
V
K
D
I
K
E
Q
E
V
Y
M
G
E
I
P
L
M
T
D
N
G
T
F
V
I
N
G
T
E
R
V
I
V
S
Q
L
H
R
S
P
G
V
F
F
D
S
D
K
G
K
T
H
S
S
G
K
V
L
Y
N
A
R
I
I
P
Y
R
G
S
W
L
D
F
E
F
D
P
K
D
N
L
F
V
R
I
D
R
R
R
K
L
P
A
T
I
I
L
R
A
L
N
Y
T
T
E
Q
I
L
D
L
F
F
E
K
V
I
F
E
I
R
D
N
K
L
QME
L
V
P
--
E
R
L
R
G
E
T
A
S
F
D
I
-
E
A
N
G
K
V
Y
V
E
K
G
R
R
I
T
A
R
H
I
R
Q
L
E
K
D
D
V
K
L
I
E
V
P
V
E
Y
I
A
G
K
V
V
A
K
D
Y
I
DESTGELICA
A
N
M
E
L
S
L
D
L
L
A
K
L
S
Q
S
G
H
K
R
I
------
E
T
L
F
T
N
D
L
D
H
G
P
Y
I
S
---------
E
T
L
R
V
D
P
T
N
D
R
L
S
-----
A
L
V
E
I
Y
R
M
M
R
P
G
E
P
P
T
R
E
A
A
E
S
L
F
E
N
L
F
F
S
E
D
R
Y
D
L
S
A
V
G
R
M
K
F
N
R
S
L
L
R
E
E
I
E
G
S
G
I
L
S
K
D
D
I
I
D
V
M
K
K
L
I
D
I
R
N
G
K
G
E
V
D
D
I
D
H
L
G
N
R
R
I
R
S
V
G
E
M
A
E
N
Q
F
R
V
G
L
V
R
V
E
R
A
V
K
E
R
L
S
L
--
G
D
L
D
T
L
M
P
Q
D
M
I
N
A
K
P
I
S
A
A
V
K
E
F
F
G
S
S
Q
L
S
Q
F
M
D
Q
N
N
P
L
S
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T
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
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A
G
F
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V
R
D
V
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P
T
H
Y
G
R
V
C
P
I
E
T
P
E
G
P
N
I
G
L
I
N
S
L
S
V
Y
A
Q
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N
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Y
G
F
L
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T
P
Y
R
K
V
T
D
G
V
V
T
D
E
I
H
Y
L
S
A
I
E
E
G
N
Y
V
I
A
Q
A
N
S
N
L
D
E
E
G
H
F
V
E
D
L
V
T
C
R
S
K
G
E
S
S
L
F
S
R
D
Q
V
D
Y
M
D
V
S
T
Q
Q
V
V
S
V
G
A
S
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
A
N
M
Q
R
Q
A
V
P
T
L
R
A
D
K
P
L
V
G
T
G
M
E
R
A
V
A
V
D
S
G
V
T
A
V
A
K
R
G
G
V
V
Q
Y
V
D
A
S
R
I
V
I
K
V
N
E
D
E
MYPG
E
A
G
I
D
I
Y
N
L
T
K
Y
T
R
S
N
Q
N
T
C
I
N
Q
M
P
C
V
S
L
G
E
P
V
E
R
G
D
V
L
A
D
G
P
S
T
D
L
G
E
L
A
L
G
Q
N
M
R
V
A
F
M
P
W
N
G
Y
N
F
E
D
S
I
L
V
S
E
R
V
V
Q
E
D
R
F
T
T
I
H
I
Q
E
L
A
C
V
S
R
D
T
K
L
G
P
E
E
I
T
A
D
I
P
N
V
G
E
A
A
L
S
K
L
D
E
S
G
I
V
Y
I
G
A
E
V
T
G
G
D
I
L
V
G
K
V
T
P
K
G
E
T
Q
L
T
P
E
E
K
L
L
R
A
I
F
G
E
K
A
S
D
V
K
D
S
S
L
R
V
P
N
G
V
S
G
T
V
I
D
V
Q
V
F
T
R
D
G
V
E
K
D
K
R
A
L
E
I
E
E
M
Q
L
K
Q
A
K
K
D
L
S
E
E
L
Q
I
L
E
A
G
L
F
S
R
I
R
A
V
L
V
A
G
---------
G
V
E
A
E
K
L
D
K
L
P
R
------
D
R
W
L
E
L
G
L
T
---
D
E
E
K
Q
N
Q
L
E
----
Q
L
A
E
Q
Y
D
E
L
K
H
E
F
E
K
K
L
E
AKRRK
I
T
Q
G
D
D
L
A
P
-
G
V
L
K
I
V
K
V
Y
L
A
V
K
R
R
I
Q
P
G
D
K
M
A
G
R
H
G
N
K
G
V
I
S
K
I
N
P
I
E
D
M
P
Y
D
E
N
G
T
P
V
D
I
V
L
N
P
L
G
V
P
S
R
M
N
I
G
Q
I
L
E
T
H
L
G
M
A
A
K
G
I
G
D
K
I
N
A
M
L
K
-
Q
Q
Q
E
V
A
K
LR
E
F
I
Q
R
A
Y
D
L
G
A
D
V
R
Q
K
V
D
L
S
-----
T
F
S
D
E
E
V
M
R
L
A
E
N
L
R
K
G
M
P
I
A
T
P
V
F
D
G
A
K
E
A
E
I
K
E
L
L
K
L
G
D
L
P
T
S
G
Q
I
R
L
Y
D
G
R
T
G
E
Q
F
E
R
P
V
T
V
G
Y
M
Y
M
L
K
L
N
H
L
V
D
D
K
M
H
A
R
S
T
G
S
Y
S
L
V
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
Y
T
L
Q
E
M
L
T
V
K
S
D
D
V
N
G
R
T
K
M
Y
K
N
I
V
D
G
N
H
Q
M
E
P
G
M
P
E
S
F
N
V
L
L
K
E
I
R
S
L
G
I
N
I
E
L
E
D
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
80.07
46%
-52
- C7 -
4YLO
1
RPOB_ECOLI
C:
[8-1339]
-------
K
K
R
I
R
K
D
F
G
K
R
P
Q
V
L
D
V
P
Y
L
L
S
I
Q
L
D
S
F
Q
K
F
I
E
Q
D
P
E
G
Q
Y
G
L
E
A
A
F
R
S
V
F
P
I
Q
S
Y
S
G
N
S
E
L
Q
Y
V
S
Y
R
L
G
E
P
V
F
D
V
Q
E
C
Q
I
R
G
V
T
Y
S
A
P
L
R
V
K
L
R
L
V
I
Y
E
R
E
A
P
E
G
T
---
V
K
D
I
K
E
Q
E
V
Y
M
G
E
I
P
L
M
T
D
N
G
T
F
V
I
N
G
T
E
R
V
I
V
S
Q
L
H
R
S
P
G
V
F
F
D
S
D
K
G
K
T
H
S
S
G
K
V
L
Y
N
A
R
I
I
P
Y
R
G
S
W
L
D
F
E
F
D
P
K
D
N
L
F
V
R
I
D
R
R
R
K
L
P
A
T
I
I
L
R
A
L
N
Y
T
T
E
Q
I
L
D
L
F
F
E
K
V
I
F
E
I
R
D
N
K
L
QME
L
V
P
--
E
R
L
R
G
E
T
A
S
F
D
I
-
E
A
N
G
K
V
Y
V
E
K
G
R
R
I
T
A
R
H
I
R
Q
L
E
K
D
D
V
K
L
I
E
V
P
V
E
Y
I
A
G
K
V
V
A
K
D
Y
I
DESTGELICA
A
N
M
E
L
S
L
D
L
L
A
K
L
S
Q
S
G
H
K
R
I
------
E
T
L
F
T
N
D
L
D
H
G
P
Y
I
S
---------
E
T
L
R
V
D
P
T
N
D
R
L
S
-----
A
L
V
E
I
Y
R
M
M
R
P
G
E
P
P
T
R
E
A
A
E
S
L
F
E
N
L
F
F
S
E
D
R
Y
D
L
S
A
V
G
R
M
K
F
N
R
S
L
L
R
E
E
I
E
G
S
G
I
L
S
K
D
D
I
I
D
V
M
K
K
L
I
D
I
R
N
G
K
G
E
V
D
D
I
D
H
L
G
N
R
R
I
R
S
V
G
E
M
A
E
N
Q
F
R
V
G
L
V
R
V
E
R
A
V
K
E
R
L
S
L
--
G
D
L
D
T
L
M
P
Q
D
M
I
N
A
K
P
I
S
A
A
V
K
E
F
F
G
S
S
Q
L
S
Q
F
M
D
Q
N
N
P
L
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T
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
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V
R
D
V
H
P
T
H
Y
G
R
V
C
P
I
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T
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E
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P
N
I
G
L
I
N
S
L
S
V
Y
A
Q
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N
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Y
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F
L
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P
Y
R
K
V
T
D
G
V
V
T
D
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Y
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N
Y
V
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A
Q
A
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N
L
D
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E
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H
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V
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D
L
V
T
C
R
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K
G
E
S
S
L
F
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D
Q
V
D
Y
M
D
V
S
T
Q
Q
V
V
S
V
G
A
S
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
A
N
M
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R
Q
A
V
P
T
L
R
A
D
K
P
L
V
G
T
G
M
E
R
A
V
A
V
D
S
G
V
T
A
V
A
K
R
G
G
V
V
Q
Y
V
D
A
S
R
I
V
I
K
V
N
E
D
E
MYPG
E
A
G
I
D
I
Y
N
L
T
K
Y
T
R
S
N
Q
N
T
C
I
N
Q
M
P
C
V
S
L
G
E
P
V
E
R
G
D
V
L
A
D
G
P
S
T
D
L
G
E
L
A
L
G
Q
N
M
R
V
A
F
M
P
W
N
G
Y
N
F
E
D
S
I
L
V
S
E
R
V
V
Q
E
D
R
F
T
T
I
H
I
Q
E
L
A
C
V
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D
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L
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P
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T
A
D
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P
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V
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A
A
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I
G
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T
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G
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L
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P
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K
L
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R
A
I
F
G
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K
A
S
D
V
K
D
S
S
L
R
V
P
N
G
V
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G
T
V
I
D
V
Q
V
F
T
R
D
G
V
E
K
D
K
R
A
L
E
I
E
E
M
Q
L
K
Q
A
K
K
D
L
S
E
E
L
Q
I
L
E
A
G
L
F
S
R
I
R
A
V
L
V
A
G
---------
G
V
E
A
E
K
L
D
K
L
P
R
------
D
R
W
L
E
L
G
L
T
---
D
E
E
K
Q
N
Q
L
E
----
Q
L
A
E
Q
Y
D
E
L
K
H
E
F
E
K
K
L
E
AKRRK
I
T
Q
G
D
D
L
A
P
-
G
V
L
K
I
V
K
V
Y
L
A
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D
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N
G
T
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V
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M
N
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Q
I
L
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T
H
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A
A
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N
A
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L
K
-
Q
Q
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LR
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Q
R
A
Y
D
L
G
A
D
V
R
Q
K
V
D
L
S
-----
T
F
S
D
E
E
V
M
R
L
A
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N
L
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K
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M
P
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A
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P
V
F
D
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A
K
E
A
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L
L
K
L
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D
L
P
T
S
G
Q
I
R
L
Y
D
G
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P
V
T
V
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Y
M
Y
M
L
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M
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T
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S
Y
S
L
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Q
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G
K
A
Q
F
G
G
Q
R
F
G
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M
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A
L
E
A
Y
G
A
A
Y
T
L
Q
E
M
L
T
V
K
S
D
D
V
N
G
R
T
K
M
Y
K
N
I
V
D
G
N
H
Q
M
E
P
G
M
P
E
S
F
N
V
L
L
K
E
I
R
S
L
G
I
N
I
E
L
E
D
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
80.01
46%
-50
- C7 -
4YLP
1
RPOB_ECOLI
C:
[8-1339]
-------
K
K
R
I
R
K
D
F
G
K
R
P
Q
V
L
D
V
P
Y
L
L
S
I
Q
L
D
S
F
Q
K
F
I
E
Q
D
P
E
G
Q
Y
G
L
E
A
A
F
R
S
V
F
P
I
Q
S
Y
S
G
N
S
E
L
Q
Y
V
S
Y
R
L
G
E
P
V
F
D
V
Q
E
C
Q
I
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G
V
T
Y
S
A
P
L
R
V
K
L
R
L
V
I
Y
E
R
E
A
P
E
G
T
---
V
K
D
I
K
E
Q
E
V
Y
M
G
E
I
P
L
M
T
D
N
G
T
F
V
I
N
G
T
E
R
V
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V
S
Q
L
H
R
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P
G
V
F
F
D
S
D
K
G
K
T
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S
S
G
K
V
L
Y
N
A
R
I
I
P
Y
R
G
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W
L
D
F
E
F
D
P
K
D
N
L
F
V
R
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D
R
R
R
K
L
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A
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L
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A
L
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Y
T
T
E
Q
I
L
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L
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F
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K
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K
L
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L
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--
E
R
L
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A
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-
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A
N
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A
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L
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K
D
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V
K
L
I
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V
P
V
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Y
I
A
G
K
V
V
A
K
D
Y
I
DESTGELICA
A
N
M
E
L
S
L
D
L
L
A
K
L
S
Q
S
G
H
K
R
I
------
E
T
L
F
T
N
D
L
D
H
G
P
Y
I
S
---------
E
T
L
R
V
D
P
T
N
D
R
L
S
-----
A
L
V
E
I
Y
R
M
M
R
P
G
E
P
P
T
R
E
A
A
E
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L
F
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L
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F
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D
R
Y
D
L
S
A
V
G
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M
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F
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L
L
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G
S
G
I
L
S
K
D
D
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I
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V
M
K
K
L
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R
N
G
K
G
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D
D
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L
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R
R
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V
G
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M
A
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N
Q
F
R
V
G
L
V
R
V
E
R
A
V
K
E
R
L
S
L
--
G
D
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D
M
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N
A
K
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A
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M
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A
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L
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D
D
A
N
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A
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M
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A
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M
Q
R
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A
V
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A
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A
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A
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D
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MYPG
E
A
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I
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L
T
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Y
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C
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A
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K
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A
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K
D
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G
V
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T
V
I
D
V
Q
V
F
T
R
D
G
V
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K
D
K
R
A
L
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I
E
E
M
Q
L
K
Q
A
K
K
D
L
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E
E
L
Q
I
L
E
A
G
L
F
S
R
I
R
A
V
L
V
A
G
---------
G
V
E
A
E
K
L
D
K
L
P
R
------
D
R
W
L
E
L
G
L
T
---
D
E
E
K
Q
N
Q
L
E
----
Q
L
A
E
Q
Y
D
E
L
K
H
E
F
E
K
K
L
E
AKRRK
I
T
Q
G
D
D
L
A
P
-
G
V
L
K
I
V
K
V
Y
L
A
V
K
R
R
I
Q
P
G
D
K
M
A
G
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L
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V
P
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M
N
I
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H
L
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M
A
A
K
G
I
G
D
K
I
N
A
M
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-
Q
Q
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A
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LR
E
F
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R
A
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D
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A
D
V
R
Q
K
V
D
L
S
-----
T
F
S
D
E
E
V
M
R
L
A
E
N
L
R
K
G
M
P
I
A
T
P
V
F
D
G
A
K
E
A
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I
K
E
L
L
K
L
G
D
L
P
T
S
G
Q
I
R
L
Y
D
G
R
T
G
E
Q
F
E
R
P
V
T
V
G
Y
M
Y
M
L
K
L
N
H
L
V
D
D
K
M
H
A
R
S
T
G
S
Y
S
L
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T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
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M
E
V
W
A
L
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A
Y
G
A
A
Y
T
L
Q
E
M
L
T
V
K
S
D
D
V
N
G
R
T
K
M
Y
K
N
I
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D
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Q
M
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G
M
P
E
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F
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V
L
L
K
E
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R
S
L
G
I
N
I
E
L
E
D
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
79.90
46%
-51
- C7 -
4YLN
1
RPOB_ECOLI
C:
[8-1339]
-------
K
K
R
I
R
K
D
F
G
K
R
P
Q
V
L
D
V
P
Y
L
L
S
I
Q
L
D
S
F
Q
K
F
I
E
Q
D
P
E
G
Q
Y
G
L
E
A
A
F
R
S
V
F
P
I
Q
S
Y
S
G
N
S
E
L
Q
Y
V
S
Y
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L
G
E
P
V
F
D
V
Q
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C
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Y
S
A
P
L
R
V
K
L
R
L
V
I
Y
E
R
E
A
P
E
G
T
---
V
K
D
I
K
E
Q
E
V
Y
M
G
E
I
P
L
M
T
D
N
G
T
F
V
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N
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T
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R
V
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L
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G
V
F
F
D
S
D
K
G
K
T
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S
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G
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L
Y
N
A
R
I
I
P
Y
R
G
S
W
L
D
F
E
F
D
P
K
D
N
L
F
V
R
I
D
R
R
R
K
L
P
A
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A
L
N
Y
T
T
E
Q
I
L
D
L
F
F
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K
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N
K
L
QME
L
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P
--
E
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-
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A
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K
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Y
I
A
G
K
V
V
A
K
D
Y
I
DESTGELICA
A
N
M
E
L
S
L
D
L
L
A
K
L
S
Q
S
G
H
K
R
I
------
E
T
L
F
T
N
D
L
D
H
G
P
Y
I
S
---------
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T
L
R
V
D
P
T
N
D
R
L
S
-----
A
L
V
E
I
Y
R
M
M
R
P
G
E
P
P
T
R
E
A
A
E
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L
F
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L
F
F
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D
R
Y
D
L
S
A
V
G
R
M
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F
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R
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L
L
R
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E
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E
G
S
G
I
L
S
K
D
D
I
I
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V
M
K
K
L
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D
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R
N
G
K
G
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V
D
D
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L
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R
R
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S
V
G
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M
A
E
N
Q
F
R
V
G
L
V
R
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E
R
A
V
K
E
R
L
S
L
--
G
D
L
D
T
L
M
P
Q
D
M
I
N
A
K
P
I
S
A
A
V
K
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Q
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N
P
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A
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L
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C
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L
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L
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Y
A
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M
D
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V
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A
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A
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A
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A
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V
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A
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A
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R
G
G
V
V
Q
Y
V
D
A
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R
I
V
I
K
V
N
E
D
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MYPG
E
A
G
I
D
I
Y
N
L
T
K
Y
T
R
S
N
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N
T
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A
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A
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A
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A
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V
K
D
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S
L
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V
Q
V
F
T
R
D
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V
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K
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A
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M
Q
L
K
Q
A
K
K
D
L
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E
E
L
Q
I
L
E
A
G
L
F
S
R
I
R
A
V
L
V
A
G
---------
G
V
E
A
E
K
L
D
K
L
P
R
------
D
R
W
L
E
L
G
L
T
---
D
E
E
K
Q
N
Q
L
E
----
Q
L
A
E
Q
Y
D
E
L
K
H
E
F
E
K
K
L
E
AKRRK
I
T
Q
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D
D
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G
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V
N
G
R
T
K
M
Y
K
N
I
V
D
G
N
H
Q
M
E
P
G
M
P
E
S
F
N
V
L
L
K
E
I
R
S
L
G
I
N
I
E
L
E
D
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
79.88
46%
-53
- C7 -
4YLN
1
RPOB_ECOLI
I:
[8-1339]
-------
K
K
R
I
R
K
D
F
G
K
R
P
Q
V
L
D
V
P
Y
L
L
S
I
Q
L
D
S
F
Q
K
F
I
E
Q
D
P
E
G
Q
Y
G
L
E
A
A
F
R
S
V
F
P
I
Q
S
Y
S
G
N
S
E
L
Q
Y
V
S
Y
R
L
G
E
P
V
F
D
V
Q
E
C
Q
I
R
G
V
T
Y
S
A
P
L
R
V
K
L
R
L
V
I
Y
E
R
E
A
P
E
G
T
---
V
K
D
I
K
E
Q
E
V
Y
M
G
E
I
P
L
M
T
D
N
G
T
F
V
I
N
G
T
E
R
V
I
V
S
Q
L
H
R
S
P
G
V
F
F
D
S
D
K
G
K
T
H
S
S
G
K
V
L
Y
N
A
R
I
I
P
Y
R
G
S
W
L
D
F
E
F
D
P
K
D
N
L
F
V
R
I
D
R
R
R
K
L
P
A
T
I
I
L
R
A
L
N
Y
T
T
E
Q
I
L
D
L
F
F
E
K
V
I
F
E
I
R
D
N
K
L
QME
L
V
P
--
E
R
L
R
G
E
T
A
S
F
D
I
-
E
A
N
G
K
V
Y
V
E
K
G
R
R
I
T
A
R
H
I
R
Q
L
E
K
D
D
V
K
L
I
E
V
P
V
E
Y
I
A
G
K
V
V
A
K
D
Y
I
DESTGELICA
A
N
M
E
L
S
L
D
L
L
A
K
L
S
Q
S
G
H
K
R
I
------
E
T
L
F
T
N
D
L
D
H
G
P
Y
I
S
---------
E
T
L
R
V
D
P
T
N
D
R
L
S
-----
A
L
V
E
I
Y
R
M
M
R
P
G
E
P
P
T
R
E
A
A
E
S
L
F
E
N
L
F
F
S
E
D
R
Y
D
L
S
A
V
G
R
M
K
F
N
R
S
L
L
R
E
E
I
E
G
S
G
I
L
S
K
D
D
I
I
D
V
M
K
K
L
I
D
I
R
N
G
K
G
E
V
D
D
I
D
H
L
G
N
R
R
I
R
S
V
G
E
M
A
E
N
Q
F
R
V
G
L
V
R
V
E
R
A
V
K
E
R
L
S
L
--
G
D
L
D
T
L
M
P
Q
D
M
I
N
A
K
P
I
S
A
A
V
K
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F
F
G
S
S
Q
L
S
Q
F
M
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Q
N
N
P
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A
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C
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G
L
I
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L
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Y
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K
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G
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V
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Y
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N
Y
V
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A
Q
A
N
S
N
L
D
E
E
G
H
F
V
E
D
L
V
T
C
R
S
K
G
E
S
S
L
F
S
R
D
Q
V
D
Y
M
D
V
S
T
Q
Q
V
V
S
V
G
A
S
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
A
N
M
Q
R
Q
A
V
P
T
L
R
A
D
K
P
L
V
G
T
G
M
E
R
A
V
A
V
D
S
G
V
T
A
V
A
K
R
G
G
V
V
Q
Y
V
D
A
S
R
I
V
I
K
V
N
E
D
E
MYPG
E
A
G
I
D
I
Y
N
L
T
K
Y
T
R
S
N
Q
N
T
C
I
N
Q
M
P
C
V
S
L
G
E
P
V
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R
G
D
V
L
A
D
G
P
S
T
D
L
G
E
L
A
L
G
Q
N
M
R
V
A
F
M
P
W
N
G
Y
N
F
E
D
S
I
L
V
S
E
R
V
V
Q
E
D
R
F
T
T
I
H
I
Q
E
L
A
C
V
S
R
D
T
K
L
G
P
E
E
I
T
A
D
I
P
N
V
G
E
A
A
L
S
K
L
D
E
S
G
I
V
Y
I
G
A
E
V
T
G
G
D
I
L
V
G
K
V
T
P
K
G
E
T
Q
L
T
P
E
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K
L
L
R
A
I
F
G
E
K
A
S
D
V
K
D
S
S
L
R
V
P
N
G
V
S
G
T
V
I
D
V
Q
V
F
T
R
D
G
V
E
K
D
K
R
A
L
E
I
E
E
M
Q
L
K
Q
A
K
K
D
L
S
E
E
L
Q
I
L
E
A
G
L
F
S
R
I
R
A
V
L
V
A
G
---------
G
V
E
A
E
K
L
D
K
L
P
R
------
D
R
W
L
E
L
G
L
T
---
D
E
E
K
Q
N
Q
L
E
----
Q
L
A
E
Q
Y
D
E
L
K
H
E
F
E
K
K
L
E
AKRRK
I
T
Q
G
D
D
L
A
P
-
G
V
L
K
I
V
K
V
Y
L
A
V
K
R
R
I
Q
P
G
D
K
M
A
G
R
H
G
N
K
G
V
I
S
K
I
N
P
I
E
D
M
P
Y
D
E
N
G
T
P
V
D
I
V
L
N
P
L
G
V
P
S
R
M
N
I
G
Q
I
L
E
T
H
L
G
M
A
A
K
G
I
G
D
K
I
N
A
M
L
K
-
Q
Q
Q
E
V
A
K
LR
E
F
I
Q
R
A
Y
D
L
G
A
D
V
R
Q
K
V
D
L
S
-----
T
F
S
D
E
E
V
M
R
L
A
E
N
L
R
K
G
M
P
I
A
T
P
V
F
D
G
A
K
E
A
E
I
K
E
L
L
K
L
G
D
L
P
T
S
G
Q
I
R
L
Y
D
G
R
T
G
E
Q
F
E
R
P
V
T
V
G
Y
M
Y
M
L
K
L
N
H
L
V
D
D
K
M
H
A
R
S
T
G
S
Y
S
L
V
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
Y
T
L
Q
E
M
L
T
V
K
S
D
D
V
N
G
R
T
K
M
Y
K
N
I
V
D
G
N
H
Q
M
E
P
G
M
P
E
S
F
N
V
L
L
K
E
I
R
S
L
G
I
N
I
E
L
E
D
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
79.81
46%
-50
- C7 -
4YLO
1
RPOB_ECOLI
I:
[8-1339]
-------
K
K
R
I
R
K
D
F
G
K
R
P
Q
V
L
D
V
P
Y
L
L
S
I
Q
L
D
S
F
Q
K
F
I
E
Q
D
P
E
G
Q
Y
G
L
E
A
A
F
R
S
V
F
P
I
Q
S
Y
S
G
N
S
E
L
Q
Y
V
S
Y
R
L
G
E
P
V
F
D
V
Q
E
C
Q
I
R
G
V
T
Y
S
A
P
L
R
V
K
L
R
L
V
I
Y
E
R
E
A
P
E
G
T
---
V
K
D
I
K
E
Q
E
V
Y
M
G
E
I
P
L
M
T
D
N
G
T
F
V
I
N
G
T
E
R
V
I
V
S
Q
L
H
R
S
P
G
V
F
F
D
S
D
K
G
K
T
H
S
S
G
K
V
L
Y
N
A
R
I
I
P
Y
R
G
S
W
L
D
F
E
F
D
P
K
D
N
L
F
V
R
I
D
R
R
R
K
L
P
A
T
I
I
L
R
A
L
N
Y
T
T
E
Q
I
L
D
L
F
F
E
K
V
I
F
E
I
R
D
N
K
L
QME
L
V
P
--
E
R
L
R
G
E
T
A
S
F
D
I
-
E
A
N
G
K
V
Y
V
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K
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R
R
I
T
A
R
H
I
R
Q
L
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K
D
D
V
K
L
I
E
V
P
V
E
Y
I
A
G
K
V
V
A
K
D
Y
I
DESTGELICA
A
N
M
E
L
S
L
D
L
L
A
K
L
S
Q
S
G
H
K
R
I
------
E
T
L
F
T
N
D
L
D
H
G
P
Y
I
S
---------
E
T
L
R
V
D
P
T
N
D
R
L
S
-----
A
L
V
E
I
Y
R
M
M
R
P
G
E
P
P
T
R
E
A
A
E
S
L
F
E
N
L
F
F
S
E
D
R
Y
D
L
S
A
V
G
R
M
K
F
N
R
S
L
L
R
E
E
I
E
G
S
G
I
L
S
K
D
D
I
I
D
V
M
K
K
L
I
D
I
R
N
G
K
G
E
V
D
D
I
D
H
L
G
N
R
R
I
R
S
V
G
E
M
A
E
N
Q
F
R
V
G
L
V
R
V
E
R
A
V
K
E
R
L
S
L
--
G
D
L
D
T
L
M
P
Q
D
M
I
N
A
K
P
I
S
A
A
V
K
E
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F
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L
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Q
N
N
P
L
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A
L
G
P
G
G
L
T
R
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A
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V
H
P
T
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Y
G
R
V
C
P
I
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E
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I
G
L
I
N
S
L
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V
Y
A
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Y
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D
G
V
V
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N
Y
V
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A
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A
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N
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C
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V
D
Y
M
D
V
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T
Q
Q
V
V
S
V
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A
S
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
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A
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M
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A
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P
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L
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A
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K
P
L
V
G
T
G
M
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R
A
V
A
V
D
S
G
V
T
A
V
A
K
R
G
G
V
V
Q
Y
V
D
A
S
R
I
V
I
K
V
N
E
D
E
MYPG
E
A
G
I
D
I
Y
N
L
T
K
Y
T
R
S
N
Q
N
T
C
I
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Q
M
P
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L
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P
V
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G
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A
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D
L
G
E
L
A
L
G
Q
N
M
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A
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W
N
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N
F
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S
I
L
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V
V
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F
T
T
I
H
I
Q
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L
A
C
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P
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T
A
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P
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V
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A
A
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I
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L
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K
A
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D
V
K
D
S
S
L
R
V
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N
G
V
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G
T
V
I
D
V
Q
V
F
T
R
D
G
V
E
K
D
K
R
A
L
E
I
E
E
M
Q
L
K
Q
A
K
K
D
L
S
E
E
L
Q
I
L
E
A
G
L
F
S
R
I
R
A
V
L
V
A
G
---------
G
V
E
A
E
K
L
D
K
L
P
R
------
D
R
W
L
E
L
G
L
T
---
D
E
E
K
Q
N
Q
L
E
----
Q
L
A
E
Q
Y
D
E
L
K
H
E
F
E
K
K
L
E
AKRRK
I
T
Q
G
D
D
L
A
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-
G
V
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L
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A
A
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A
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L
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-----
T
F
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D
E
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V
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A
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A
A
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Q
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N
H
Q
M
E
P
G
M
P
E
S
F
N
V
L
L
K
E
I
R
S
L
G
I
N
I
E
L
E
D
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------