@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_1142: (2015-12-21 )
MDSTLKHLAIIMDGNGRWAKLKNKARAYGHKKGVKTLKDITIWCANHKLECLTLYAFSTENWKRPKSEVDFLMKMLKKYLKDERSTYLDNNIRFRAIGDLEGFSKELRDTILRLENDTRYFKDFTQVLALNYGSKNELSRAFKSLLENPPNHINNIESLENEISHRLDTHDLPEVDLLLRTGGEMRLSNFLLWQSSYAELFFTPILWPDFTPKDLENIISDFYKRVRKFGELKC
Atome Classification :
(51 SA)
.........10.-.......20........30........40........50.......-.60........70........80........90........100.......110.......120.......130.......140....-..------.150........-160-.......-170.----......180.......190.......200.......210.......220.......230..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MDST
L
K
H
L
A
I
I
M-DGNG
R
W
A
K
L
K
N
K
A
R
AYGHKKGV
K
T
L
K
D
I
T
I
W
CANHK
L
E
C
L
T
L
Y
A
FS-TENWKR
P
K
S
E
V
D
F
L
M
K
M
L
K
K
Y
L
K
D
E
R
S
T
YLDNN
I
R
F
R
A
IG
D
L
E
G
F
S
K
E
L
R
D
T
I
L
RLEN
D
T
R
Y
F
K
D
F
T
Q
V
L
A
LNYG
S
K
N
E
L
S
R
A
F
K
S
L
L-EN------PPN-HIN
N
I
E
S
L
-
E
N
E
-
I
S
HRLDT-HDLP----
E
V
D
L
LLRTGGE
M
R
L
S
N
F
L
L
W
QSS
Y
A
E
L
F
F
TPILWPDF
T
P
K
D
L
E
N
I
I
S
D
F
Y
K
R
V
R
K
FGELKC
2
PsiBlast_PDB
97.52
94%
-109
- C8 -
2DTN
-
ISPT_HELPY
A:
[14-237]
--
S
T
L
K
H
L
A
I
I
M
-
D
G
N
G
R
W
A
K
L
K
N
K
A
R
A
Y
G
H
K
K
G
V
K
T
L
K
D
I
T
I
W
C
A
N
H
K
L
E
C
L
T
L
Y
A
F
-----------
E
V
D
F
L
M
K
M
L
K
K
Y
L
K
D
E
R
S
T
Y
L
D
N
N
I
R
F
R
A
I
G
D
L
E
G
F
S
K
E
L
R
D
T
I
L
Q
L
E
N
D
T
R
H
F
K
D
F
T
Q
V
L
A
L
N
Y
G
S
K
N
E
L
S
R
A
F
K
S
L
L
-
E
S
------
P
P
S
-
N
I
S
L
L
E
S
L
-
E
N
E
-
I
S
N
R
L
D
T
-
R
N
L
P
----
E
V
D
L
L
L
R
T
G
G
E
M
R
L
S
N
F
L
L
W
Q
S
S
Y
A
E
L
F
F
T
P
I
L
W
P
D
F
T
P
K
D
L
E
N
I
I
S
D
F
Y
K
R
V
--------
21
PsiBlast_CBE
96.88
94%
-107
- C8 -
2DTN
1
ISPT_HELPY
B:
[15-242]
---
T
L
K
H
L
A
I
I
M
-
D
G
N
G
R
W
A
K
L
K
N
K
A
R
A
Y
G
H
K
K
G
V
K
T
L
K
D
I
T
I
W
C
A
N
H
K
L
E
C
L
T
L
Y
A
-----------------
M
K
M
L
K
K
Y
L
K
D
E
R
S
T
Y
L
D
N
N
I
R
F
R
A
I
G
D
L
E
G
F
S
K
E
L
R
D
T
I
L
Q
L
E
N
D
T
R
H
F
K
D
F
T
Q
V
L
A
L
N
Y
G
S
K
N
E
L
S
R
A
F
K
S
L
L
-
E
S
------
P
----------
L
-
E
N
E
-
I
S
N
R
L
D
T
-
R
N
L
P
----
E
V
D
L
L
L
R
T
G
G
E
M
R
L
S
N
F
L
L
W
Q
S
S
Y
A
E
L
F
F
T
P
I
L
W
P
D
F
T
P
K
D
L
E
N
I
I
S
D
F
Y
K
R
V
R
K
F
G
E
---
1
PsiBlast_PDB
96.51
94%
-110
- C8 -
2D2R
-
ISPT_HELPY
A:
[3-227]
--
S
T
L
K
H
L
A
I
I
M
-
D
G
N
G
R
W
A
K
L
K
N
K
A
R
A
Y
G
H
K
K
G
V
K
T
L
K
D
I
T
I
W
C
A
N
H
K
L
E
C
L
T
L
Y
A
F
-----------
E
V
D
F
L
M
K
M
L
K
K
Y
L
K
D
E
R
S
T
Y
L
D
N
N
I
R
F
R
A
I
G
D
L
E
G
F
S
K
E
L
R
D
T
I
L
Q
L
E
N
D
T
R
H
F
K
D
F
T
Q
V
L
A
L
N
Y
G
S
K
N
E
L
S
R
A
F
K
S
L
L
-
E
S
------
P
P
S
-
N
I
S
L
L
E
S
L
-
E
N
E
-
I
S
N
R
L
D
T
-
R
N
L
P
----
E
V
D
L
L
L
R
T
G
G
E
M
R
L
S
N
F
L
L
W
Q
S
S
Y
A
E
L
F
F
T
P
I
L
W
P
D
F
T
P
K
D
L
E
N
I
I
S
D
F
Y
K
R
V
R
-------
85
HHSearch
95.50
94%
-106
- C8 -
2D2R
-
ISPT_HELPY
A:
[3-227]
--
S
T
L
K
H
L
A
I
I
M
-
D
G
N
G
R
W
A
K
L
K
N
K
A
R
A
Y
G
H
K
K
G
V
K
T
L
K
D
I
T
I
W
C
A
N
H
K
L
E
C
L
T
L
Y
A
F
-----------
E
V
D
F
L
M
K
M
L
K
K
Y
L
K
D
E
R
S
T
Y
L
D
N
N
I
R
F
R
A
I
G
D
L
E
G
F
S
K
E
L
R
D
T
I
L
Q
L
E
N
D
T
R
H
F
K
D
F
T
Q
V
L
A
L
N
Y
G
S
K
N
E
L
S
R
A
F
K
S
L
L
-
E
S
------
P
P
S
-
N
-
I
S
L
L
E
S
L
E
N
E
-
I
S
N
R
L
D
T
-
R
N
L
P
----
E
V
D
L
L
L
R
T
G
G
E
M
R
L
S
N
F
L
L
W
Q
S
S
Y
A
E
L
F
F
T
P
I
L
W
P
D
F
T
P
K
D
L
E
N
I
I
S
D
F
Y
K
R
V
R
-------
4
PsiBlast_PDB
84.11
42%
-92
- C8 -
1V7U
2
UPPS_ECOLI
A:
[19-239]
-----
R
H
V
A
I
I
M
-
D
G
N
G
R
W
A
K
K
Q
G
K
I
R
A
F
G
H
K
A
G
A
K
S
V
R
R
A
V
S
F
A
A
N
N
G
I
E
A
L
T
L
Y
A
F
S
-
S
E
N
W
N
R
P
A
Q
E
V
S
A
L
M
E
L
F
V
W
A
L
D
S
E
V
K
S
L
H
R
H
N
V
R
L
R
I
I
G
D
T
S
R
F
N
S
R
L
Q
E
R
I
R
K
S
E
A
L
T
A
G
N
T
G
L
T
L
N
I
A
A
N
Y
G
G
R
W
D
I
V
Q
G
V
R
Q
L
A
-
E
K
V
Q
Q
GNL
Q
P
D
-
Q
I
D
------
E
E
M
-
L
N
Q
H
V
C
M
-
H
E
L
A
----
P
V
D
L
V
I
R
T
G
G
E
H
R
I
S
N
F
L
L
W
Q
I
A
Y
A
E
L
Y
F
T
D
V
L
W
P
D
F
D
E
Q
D
F
E
G
A
L
N
A
F
A
N
R
---------
43
PsiBlast_CBE
83.80
42%
-93
- C8 -
1X08
3
UPPS_ECOLI
A:
[19-240]
-----
R
H
V
A
I
I
M
-
A
G
N
G
R
W
A
K
K
Q
G
K
I
R
A
F
G
H
K
A
G
A
K
S
V
R
R
A
V
S
F
A
A
N
N
G
I
E
A
L
T
L
Y
A
F
S
-
S
E
N
W
N
R
P
A
Q
E
V
S
A
L
M
E
L
F
V
W
A
L
D
S
E
V
K
S
L
H
R
H
N
V
R
L
R
I
I
G
D
T
S
R
F
N
S
R
L
Q
E
R
I
R
K
S
E
A
L
T
A
G
N
T
G
L
T
L
N
I
A
A
N
Y
G
G
R
W
D
I
V
Q
G
V
R
Q
L
A
-
E
K
V
Q
Q
GNL
Q
P
D
-
Q
I
D
------
E
E
M
-
L
N
Q
H
V
C
M
-
H
E
L
A
----
P
V
D
L
V
I
R
T
G
G
E
H
R
I
S
N
F
L
L
W
Q
I
A
Y
A
E
L
Y
F
T
D
V
L
W
P
D
F
D
E
Q
D
F
E
G
A
L
N
A
F
A
N
R
E
--------
34
PsiBlast_CBE
83.66
42%
-96
- C8 -
2E9D
1
UPPS_ECOLI
B:
[19-243]
-----
R
H
V
A
I
I
M
-
D
G
N
G
R
W
A
K
K
Q
G
K
I
R
A
F
G
H
K
A
G
A
K
S
V
R
R
A
V
S
F
A
A
N
N
G
I
E
A
L
T
L
Y
A
F
S
-
S
----------
S
A
L
M
E
L
F
V
W
A
L
D
S
E
V
K
S
L
H
R
H
N
V
R
L
R
I
I
G
D
T
S
R
F
N
S
R
L
Q
E
R
I
R
K
S
E
A
L
T
A
G
N
T
G
L
T
L
N
I
A
A
N
Y
G
G
R
W
D
I
V
Q
G
V
R
Q
L
A
-
E
K
V
Q
Q
GNL
Q
P
D
-
Q
I
D
------
E
E
M
-
L
N
Q
H
V
C
M
-
H
E
L
A
----
P
V
D
L
V
I
R
T
G
G
E
H
R
I
S
N
F
L
L
W
Q
I
A
Y
A
E
L
Y
F
T
D
V
L
W
P
D
F
D
E
Q
D
F
E
G
A
L
N
A
F
A
N
R
E
R
R
F
-----
40
PsiBlast_CBE
83.33
42%
-93
- C8 -
1UEH
9
UPPS_ECOLI
B:
[19-241]
-----
R
H
V
A
I
I
M
-
D
G
N
G
R
W
A
K
K
Q
G
K
I
R
A
F
G
H
K
A
G
A
K
S
V
R
R
A
V
S
F
A
A
N
N
G
I
E
A
L
T
L
Y
A
F
S
-
S
E
N
W
N
R
P
A
Q
E
V
S
A
L
M
E
L
F
V
W
A
L
D
S
E
V
K
S
L
H
R
H
N
V
R
L
R
I
I
G
D
T
S
R
F
N
S
R
L
Q
E
R
I
R
K
S
E
A
L
T
A
G
N
T
G
L
T
L
N
I
A
A
N
Y
G
G
R
W
D
I
V
Q
G
V
R
Q
L
A
-
E
K
V
Q
Q
GNL
Q
P
D
-
Q
I
D
------
E
E
M
-
L
N
Q
H
V
C
M
-
H
E
L
A
----
P
V
D
L
V
I
R
T
G
G
E
H
R
I
S
N
F
L
L
W
Q
I
A
Y
A
E
L
Y
F
T
D
V
L
W
P
D
F
D
E
Q
D
F
E
G
A
L
N
A
F
A
N
R
E
R
-------
49
PsiBlast_CBE
83.25
39%
-84
- C8 -
4H8E
3
ISPT_STAAN
A:
[26-253]
-----
E
H
I
A
I
I
M
-
D
G
N
G
R
W
A
K
K
R
K
M
P
R
I
K
G
H
Y
E
G
M
Q
T
I
K
K
I
T
R
I
A
S
D
I
G
V
K
Y
L
T
L
Y
A
F
S
-
T
E
N
W
S
R
P
E
S
E
V
N
Y
I
M
N
L
P
V
N
F
L
K
T
F
L
P
E
L
I
E
K
N
V
K
V
E
T
I
G
F
T
D
K
L
P
K
S
T
I
E
A
I
N
N
A
K
E
K
T
A
N
N
T
G
L
K
L
I
F
A
I
N
Y
G
G
R
A
E
L
V
H
S
I
K
N
M
F
-
D
E
------
L
H
Q
-
Q
G
L
N
S
D
I
I
D
E
T
Y
-
I
N
N
H
L
M
T
-
K
D
Y
P
----
D
P
E
L
L
I
R
T
S
G
E
Q
R
I
S
N
F
L
I
W
Q
V
S
Y
S
E
F
I
F
N
Q
K
L
W
P
D
F
D
E
D
E
L
I
K
C
I
K
I
Y
Q
S
R
Q
R
R
F
G
G
L
--
48
PsiBlast_CBE
83.02
39%
-82
- C8 -
4U82
3
ISPT_STAAN
A:
[26-253]
-----
E
H
I
A
I
I
M
-
D
G
N
G
R
W
A
K
K
R
K
M
P
R
I
K
G
H
Y
E
G
M
Q
T
I
K
K
I
T
R
I
A
S
D
I
G
V
K
Y
L
T
L
Y
A
F
S
-
T
E
N
W
S
R
P
E
S
E
V
N
Y
I
M
N
L
P
V
N
F
L
K
T
F
L
P
E
L
I
E
K
N
V
K
V
E
T
I
G
F
T
D
K
L
P
K
S
T
I
E
A
I
N
N
A
K
E
K
T
A
N
N
T
G
L
K
L
I
F
A
I
N
Y
G
G
R
A
E
L
V
H
S
I
K
N
M
F
-
D
E
------
L
H
Q
-
Q
G
L
N
S
D
I
I
D
E
T
Y
-
I
N
N
H
L
M
T
-
K
D
Y
P
----
D
P
E
L
L
I
R
T
S
G
E
Q
R
I
S
N
F
L
I
W
Q
V
S
Y
S
E
F
I
F
N
Q
K
L
W
P
D
F
D
E
D
E
L
I
K
C
I
K
I
Y
Q
S
R
Q
R
R
F
G
G
L
S
-
38
PsiBlast_CBE
83.02
42%
-100
- C8 -
2E98
3
UPPS_ECOLI
B:
[19-243]
-----
R
H
V
A
I
I
M
-
D
G
N
G
R
W
A
K
K
Q
G
K
I
R
A
F
G
H
K
A
G
A
K
S
V
R
R
A
V
S
F
A
A
N
N
G
I
E
A
L
T
L
Y
A
F
S
-
S
----------
S
A
L
M
E
L
F
V
W
A
L
D
S
E
V
K
S
L
H
R
H
N
V
R
L
R
I
I
G
D
T
S
R
F
N
S
R
L
Q
E
R
I
R
K
S
E
A
L
T
A
G
N
T
G
L
T
L
N
I
A
A
N
Y
G
G
R
W
D
I
V
Q
G
V
R
Q
L
A
-
E
K
V
Q
Q
GNL
Q
P
D
-
Q
I
D
------
E
E
M
-
L
N
Q
H
V
C
M
-
H
E
L
A
----
P
V
D
L
V
I
R
T
G
G
E
H
R
I
S
N
F
L
L
W
Q
I
A
Y
A
E
L
Y
F
T
D
V
L
W
P
D
F
D
E
Q
D
F
E
G
A
L
N
A
F
A
N
R
E
R
R
F
-----
39
PsiBlast_CBE
82.98
42%
-99
- C8 -
1V7U
1
UPPS_ECOLI
B:
[19-240]
-----
R
H
V
A
I
I
M
-
D
G
N
G
R
W
A
K
K
Q
G
K
I
R
A
F
G
H
K
A
G
A
K
S
V
R
R
A
V
S
F
A
A
N
N
G
I
E
A
L
T
L
Y
A
F
S
-
S
E
----
P
A
Q
E
V
S
A
L
M
E
L
F
V
W
A
L
D
S
E
V
K
S
L
H
R
H
N
V
R
L
R
I
I
G
D
T
S
R
F
N
S
R
L
Q
E
R
I
R
K
S
E
A
L
T
A
G
N
T
G
L
T
L
N
I
A
A
N
Y
G
G
R
W
D
I
V
Q
G
V
R
Q
L
A
-
E
K
V
Q
Q
GNL
Q
P
D
-
Q
I
D
------
E
E
M
-
L
N
Q
H
V
C
M
-
H
E
L
A
----
P
V
D
L
V
I
R
T
G
G
E
H
R
I
S
N
F
L
L
W
Q
I
A
Y
A
E
L
Y
F
T
D
V
L
W
P
D
F
D
E
Q
D
F
E
G
A
L
N
A
F
A
N
R
E
--------
55
PsiBlast_CBE
82.94
37%
-84
- C8 -
4ONC
2
DPDS_MYCTU
B:
[53-282]
-
D
R
L
P
N
H
V
A
I
V
M
-
D
G
N
G
R
W
A
T
Q
R
G
L
A
R
T
E
G
H
K
M
G
E
A
V
V
I
D
I
A
C
G
A
I
E
L
G
I
K
W
L
S
L
Y
A
F
S
-
T
E
N
W
K
R
S
P
E
E
V
R
F
L
M
G
F
N
R
D
V
V
R
R
R
R
D
T
L
K
K
L
G
V
R
I
R
W
V
G
S
R
P
R
L
W
R
S
V
I
N
E
L
A
V
A
E
E
M
T
K
S
N
D
V
I
T
I
N
Y
C
V
N
Y
G
G
R
T
E
I
T
E
A
T
R
E
I
A
R
E
V
------
A
A
G
-
R
L
N
P
E
R
I
T
-
E
S
T
-
I
A
R
H
L
Q
R
-
P
D
I
P
----
D
V
D
L
F
L
R
T
S
G
E
Q
R
S
S
N
F
M
L
W
Q
A
A
Y
A
E
Y
I
F
Q
D
K
L
W
P
D
Y
D
R
R
D
L
W
A
A
C
E
E
Y
A
S
R
T
R
R
F
G
S
A
--
37
PsiBlast_CBE
82.88
42%
-101
- C8 -
2E99
2
UPPS_ECOLI
B:
[19-243]
-----
R
H
V
A
I
I
M
-
D
G
N
G
R
W
A
K
K
Q
G
K
I
R
A
F
G
H
K
A
G
A
K
S
V
R
R
A
V
S
F
A
A
N
N
G
I
E
A
L
T
L
Y
A
F
S
-
S
----------
S
A
L
M
E
L
F
V
W
A
L
D
S
E
V
K
S
L
H
R
H
N
V
R
L
R
I
I
G
D
T
S
R
F
N
S
R
L
Q
E
R
I
R
K
S
E
A
L
T
A
G
N
T
G
L
T
L
N
I
A
A
N
Y
G
G
R
W
D
I
V
Q
G
V
R
Q
L
A
-
E
K
V
Q
Q
GNL
Q
P
D
-
Q
I
D
------
E
E
M
-
L
N
Q
H
V
C
M
-
H
E
L
A
----
P
V
D
L
V
I
R
T
G
G
E
H
R
I
S
N
F
L
L
W
Q
I
A
Y
A
E
L
Y
F
T
D
V
L
W
P
D
F
D
E
Q
D
F
E
G
A
L
N
A
F
A
N
R
E
R
R
F
-----
17
PsiBlast_PDB
82.80
42%
-101
- C8 -
3SH0
2
UPPS_ECOLI
B:
[19-240]
-----
R
H
V
A
I
I
M
-
D
G
N
G
R
W
A
K
K
Q
G
K
I
R
A
F
G
H
K
A
G
A
K
S
V
R
R
A
V
S
F
A
A
N
N
G
I
E
A
L
T
L
Y
A
F
S
-
S
------
A
Q
E
V
S
A
L
M
E
L
F
V
W
A
L
D
S
E
V
K
S
L
H
R
H
N
V
R
L
R
I
I
G
D
T
S
R
F
N
S
R
L
Q
E
R
I
R
K
S
E
A
L
T
A
G
N
T
G
L
T
L
N
I
A
A
N
Y
G
G
R
W
D
I
V
Q
G
V
R
Q
L
A
-
E
K
V
Q
Q
GNL
Q
P
D
-
Q
I
D
------
E
E
M
-
L
N
Q
H
V
C
M
-
H
E
L
A
----
P
V
D
L
V
I
R
T
G
G
E
H
R
I
S
N
F
L
L
W
Q
I
A
Y
A
E
L
Y
F
T
D
V
L
W
P
D
F
D
E
Q
D
F
E
G
A
L
N
A
F
A
N
R
E
--------
5
PsiBlast_PDB
82.57
42%
-91
- C8 -
1X06
4
UPPS_ECOLI
A:
[19-240]
-----
R
H
V
A
I
I
M
-
D
G
N
G
R
W
A
K
K
Q
G
K
I
R
A
F
G
H
K
A
G
A
K
S
V
R
R
A
V
S
F
A
A
N
N
G
I
E
A
L
T
L
Y
A
F
S
-
S
E
N
W
N
R
P
A
Q
E
V
S
A
L
M
E
L
F
V
W
A
L
D
S
E
V
K
S
L
H
R
H
N
V
R
L
R
I
I
G
D
T
S
R
F
N
S
R
L
Q
E
R
I
R
K
S
E
A
L
T
A
G
N
T
G
L
T
L
N
I
A
A
N
Y
G
G
R
W
D
I
V
Q
G
V
R
Q
L
A
-
E
K
V
Q
Q
GNL
Q
P
D
-
Q
I
D
------
E
E
M
-
L
N
Q
H
V
C
M
-
H
E
L
A
----
P
V
D
L
V
I
R
T
G
G
E
H
R
I
S
N
F
L
L
W
Q
I
A
Y
A
E
L
Y
F
T
D
V
L
W
P
D
F
D
E
Q
D
F
E
G
A
L
N
A
F
A
N
R
E
--------
42
PsiBlast_CBE
82.50
42%
-92
- C8 -
1X09
3
UPPS_ECOLI
A:
[19-239]
-----
R
H
V
A
I
I
M
-
A
G
N
G
R
W
A
K
K
Q
G
K
I
R
A
F
G
H
K
A
G
A
K
S
V
R
R
A
V
S
F
A
A
N
N
G
I
E
A
L
T
L
Y
A
F
S
-
S
E
N
W
N
R
P
A
Q
E
V
S
A
L
M
E
L
F
V
W
A
L
D
S
E
V
K
S
L
H
R
H
N
V
R
L
R
I
I
G
D
T
S
R
F
N
S
R
L
Q
E
R
I
R
K
S
E
A
L
T
A
G
N
T
G
L
T
L
N
I
A
A
N
Y
G
G
R
W
D
I
V
Q
G
V
R
Q
L
A
-
E
K
V
Q
Q
GNL
Q
P
D
-
Q
I
D
------
E
E
M
-
L
N
Q
H
V
C
M
-
H
E
L
A
----
P
V
D
L
V
I
R
T
G
G
E
H
R
I
S
N
F
L
L
W
Q
I
A
Y
A
E
L
Y
F
T
D
V
L
W
P
D
F
D
E
Q
D
F
E
G
A
L
N
A
F
A
N
R
---------
36
PsiBlast_CBE
82.44
42%
-99
- C8 -
2E9A
1
UPPS_ECOLI
B:
[19-242]
-----
R
H
V
A
I
I
M
-
D
G
N
G
R
W
A
K
K
Q
G
K
I
R
A
F
G
H
K
A
G
A
K
S
V
R
R
A
V
S
F
A
A
N
N
G
I
E
A
L
T
L
Y
A
F
S
-------------
A
L
M
E
L
F
V
W
A
L
D
S
E
V
K
S
L
H
R
H
N
V
R
L
R
I
I
G
D
T
S
R
F
N
S
R
L
Q
E
R
I
R
K
S
E
A
L
T
A
G
N
T
G
L
T
L
N
I
A
A
N
Y
G
G
R
W
D
I
V
Q
G
V
R
Q
L
A
-
E
K
V
Q
Q
GNL
Q
P
D
-
Q
I
D
------
E
E
M
-
L
N
Q
H
V
C
M
-
H
E
L
A
----
P
V
D
L
V
I
R
T
G
G
E
H
R
I
S
N
F
L
L
W
Q
I
A
Y
A
E
L
Y
F
T
D
V
L
W
P
D
F
D
E
Q
D
F
E
G
A
L
N
A
F
A
N
R
E
R
R
------
30
PsiBlast_CBE
82.31
42%
-97
- C8 -
3WYJ
1
UPPS_ECOLI
A:
[19-240]
-----
R
H
V
A
I
I
M
-
D
G
N
G
R
W
A
K
K
Q
G
K
I
R
A
F
G
H
K
A
G
A
K
S
V
R
R
A
V
S
F
A
A
N
N
G
I
E
A
L
T
L
Y
A
F
S
-
S
-----
P
A
Q
E
V
S
A
L
M
E
L
F
V
W
A
L
D
S
E
V
K
S
L
H
R
H
N
V
R
L
R
I
I
G
D
T
S
R
F
N
S
R
L
Q
E
R
I
R
K
S
E
A
L
T
A
G
N
T
G
L
T
L
N
I
A
A
N
Y
G
G
R
W
D
I
V
Q
G
V
R
Q
L
A
-
E
K
V
Q
Q
GNL
Q
P
D
-
Q
I
D
------
E
E
M
-
L
N
Q
H
V
C
M
-
H
E
L
A
----
P
V
D
L
V
I
R
T
G
G
E
H
R
I
S
N
F
L
L
W
Q
I
A
Y
A
E
L
Y
F
T
D
V
L
W
P
D
F
D
E
Q
D
F
E
G
A
L
N
A
F
A
N
R
E
--------
6
PsiBlast_PDB
82.14
42%
-95
- C8 -
1X07
3
UPPS_ECOLI
A:
[19-240]
-----
R
H
V
A
I
I
M
-
D
G
N
G
R
W
A
K
K
Q
G
K
I
R
A
F
G
H
K
A
G
A
K
S
V
R
R
A
V
S
F
A
A
N
N
G
I
E
A
L
T
L
Y
A
F
S
-
S
E
N
W
N
R
P
A
Q
E
V
S
A
L
M
E
L
F
V
W
A
L
D
S
E
V
K
S
L
H
R
H
N
V
R
L
R
I
I
G
D
T
S
R
F
N
S
R
L
Q
E
R
I
R
K
S
E
A
L
T
A
G
N
T
G
L
T
L
N
I
A
A
N
Y
G
G
R
W
D
I
V
Q
G
V
R
Q
L
A
-
E
K
V
Q
Q
GNL
Q
P
D
-
Q
I
D
------
E
E
M
-
L
N
Q
H
V
C
M
-
H
E
L
A
----
P
V
D
L
V
I
R
T
G
G
E
H
R
I
S
N
F
L
L
W
Q
I
A
Y
A
E
L
Y
F
T
D
V
L
W
P
D
F
D
E
Q
D
F
E
G
A
L
N
A
F
A
N
R
E
--------
81
HHSearch
82.05
42%
-94
* C8 *
3SGV
2
UPPS_ECOLI
B:
[15-240]
-
A
H
G
C
R
H
V
A
I
I
M
-
D
G
N
G
R
W
A
K
K
Q
G
K
I
R
A
F
G
H
K
A
G
A
K
S
V
R
R
A
V
S
F
A
A
N
N
G
I
E
A
L
T
L
Y
A
F
------------
V
S
A
L
M
E
L
F
V
W
A
L
D
S
E
V
K
S
L
H
R
H
N
V
R
L
R
I
I
G
D
T
S
R
F
N
S
R
L
Q
E
R
I
R
K
S
E
A
L
T
A
G
N
T
G
L
T
L
N
I
A
A
N
Y
G
G
R
W
D
I
V
Q
G
V
R
Q
L
A
-
E
K
------
V
Q
Q
-
G
N
L
Q
P
D
Q
I
D
E
E
M
-
L
N
Q
H
V
C
M
-
H
E
L
A
----
P
V
D
L
V
I
R
T
G
G
E
H
R
I
S
N
F
L
L
W
Q
I
A
Y
A
E
L
Y
F
T
D
V
L
W
P
D
F
D
E
Q
D
F
E
G
A
L
N
A
F
A
N
R
E
--------
64
PsiBlast_CBE
81.89
37%
-80
- C8 -
2VG2
9
DPDS_MYCTU
A:
[53-282]
-
D
R
L
P
N
H
V
A
I
V
M
-
D
G
N
G
R
W
A
T
Q
R
G
L
A
R
T
E
G
H
K
M
G
E
A
V
V
I
D
I
A
C
G
A
I
E
L
G
I
K
W
L
S
L
Y
A
F
S
-
T
E
N
W
K
R
S
P
E
E
V
R
F
L
M
G
F
N
R
D
V
V
R
R
R
R
D
T
L
K
K
L
G
V
R
I
R
W
V
G
S
R
P
R
L
W
R
S
V
I
N
E
L
A
V
A
E
E
M
T
K
S
N
D
V
I
T
I
N
Y
C
V
N
Y
G
G
R
T
E
I
T
E
A
T
R
E
I
A
R
E
V
------
A
A
G
-
R
L
N
P
E
R
I
T
-
E
S
T
-
I
A
R
H
L
Q
R
-
P
D
I
P
----
D
V
D
L
F
L
R
T
S
G
E
Q
R
S
S
N
F
M
L
W
Q
A
A
Y
A
E
Y
I
F
Q
D
K
L
W
P
D
Y
D
R
R
D
L
W
A
A
C
E
E
Y
A
S
R
T
R
R
F
G
S
A
--
14
PsiBlast_PDB
81.75
42%
-95
- C8 -
3SGT
1
UPPS_ECOL6
B:
[19-240]
-----
R
H
V
A
I
I
M
-
D
G
N
G
R
W
A
K
K
Q
G
K
I
R
A
F
G
H
K
A
G
A
K
S
V
R
R
A
V
S
F
A
A
N
N
G
I
E
A
L
T
L
Y
A
F
S
-
S
E
N
---
P
A
Q
E
V
S
A
L
M
E
L
F
V
W
A
L
D
S
E
V
K
S
L
H
R
H
N
V
R
L
R
I
I
G
D
T
S
R
F
N
S
R
L
Q
E
R
I
R
K
S
E
A
L
T
A
G
N
T
G
L
T
L
N
I
A
A
N
Y
G
G
R
W
D
I
V
Q
G
V
R
Q
L
A
-
E
K
V
Q
Q
GNL
Q
P
D
-
Q
I
D
------
E
E
M
-
L
N
Q
H
V
C
M
-
H
E
L
A
----
P
V
D
L
V
I
R
T
G
G
E
H
R
I
S
N
F
L
L
W
Q
I
A
Y
A
E
L
Y
F
T
D
V
L
W
P
D
F
D
E
Q
D
F
E
G
A
L
N
A
F
A
N
R
E
--------
33
PsiBlast_CBE
81.59
42%
-95
- C8 -
3SGV
3
UPPS_ECOLI
A:
[19-238]
-----
R
H
V
A
I
I
M
-
D
G
N
G
R
W
A
K
K
Q
G
K
I
R
A
F
G
H
K
A
G
A
K
S
V
R
R
A
V
S
F
A
A
N
N
G
I
E
A
L
T
L
Y
A
F
S
-
S
E
N
W
N
R
P
A
Q
E
V
S
A
L
M
E
L
F
V
W
A
L
D
S
E
V
K
S
L
H
R
H
N
V
R
L
R
I
I
G
D
T
S
R
F
N
S
R
L
Q
E
R
I
R
K
S
E
A
L
T
A
G
N
T
G
L
T
L
N
I
A
A
N
Y
G
G
R
W
D
I
V
Q
G
V
R
Q
L
A
-
E
K
V
Q
Q
GNL
Q
P
D
-
Q
I
D
------
E
E
M
-
L
N
Q
H
V
C
M
-
H
E
L
A
----
P
V
D
L
V
I
R
T
G
G
E
H
R
I
S
N
F
L
L
W
Q
I
A
Y
A
E
L
Y
F
T
D
V
L
W
P
D
F
D
E
Q
D
F
E
G
A
L
N
A
F
A
N
----------
56
PsiBlast_CBE
81.56
37%
-83
- C8 -
4ONC
1
DPDS_MYCTU
A:
[53-280]
-
D
R
L
P
N
H
V
A
I
V
M
-
D
G
N
G
R
W
A
T
Q
R
G
L
A
R
T
E
G
H
K
M
G
E
A
V
V
I
D
I
A
C
G
A
I
E
L
G
I
K
W
L
S
L
Y
A
F
S
-
T
E
N
W
K
R
S
P
E
E
V
R
F
L
M
G
F
N
R
D
V
V
R
R
R
R
D
T
L
K
K
L
G
V
R
I
R
W
V
G
S
R
P
R
L
W
R
S
V
I
N
E
L
A
V
A
E
E
M
T
K
S
N
D
V
I
T
I
N
Y
C
V
N
Y
G
G
R
T
E
I
T
E
A
T
R
E
I
A
R
E
V
------
A
A
G
-
R
L
N
P
E
R
I
T
-
E
S
T
-
I
A
R
H
L
Q
R
-
P
D
I
P
----
D
V
D
L
F
L
R
T
S
G
E
Q
R
S
S
N
F
M
L
W
Q
A
A
Y
A
E
Y
I
F
Q
D
K
L
W
P
D
Y
D
R
R
D
L
W
A
A
C
E
E
Y
A
S
R
T
R
R
------
62
PsiBlast_CBE
81.53
37%
-84
- C8 -
2VG2
8
DPDS_MYCTU
C:
[53-282]
-
D
R
L
P
N
H
V
A
I
V
M
-
D
G
N
G
R
W
A
T
Q
R
G
L
A
R
T
E
G
H
K
M
G
E
A
V
V
I
D
I
A
C
G
A
I
E
L
G
I
K
W
L
S
L
Y
A
F
S
-
T
E
N
W
K
R
S
P
E
E
V
R
F
L
M
G
F
N
R
D
V
V
R
R
R
R
D
T
L
K
K
L
G
V
R
I
R
W
V
G
S
R
P
R
L
W
R
S
V
I
N
E
L
A
V
A
E
E
M
T
K
S
N
D
V
I
T
I
N
Y
C
V
N
Y
G
G
R
T
E
I
T
E
A
T
R
E
I
A
R
E
V
------
A
A
G
-
R
L
N
P
E
R
I
T
-
E
S
T
-
I
A
R
H
L
Q
R
-
P
D
I
P
----
D
V
D
L
F
L
R
T
S
G
E
Q
R
S
S
N
F
M
L
W
Q
A
A
Y
A
E
Y
I
F
Q
D
K
L
W
P
D
Y
D
R
R
D
L
W
A
A
C
E
E
Y
A
S
R
T
R
R
F
G
S
A
--
35
PsiBlast_CBE
81.48
42%
-93
- C8 -
2E9C
1
UPPS_ECOLI
B:
[19-239]
-----
R
H
V
A
I
I
M
-
D
G
N
G
R
W
A
K
K
Q
G
K
I
R
A
F
G
H
K
A
G
A
K
S
V
R
R
A
V
S
F
A
A
N
N
G
I
E
A
L
T
L
Y
A
F
S
-
S
----------
S
A
L
M
E
L
F
V
W
A
L
D
S
E
V
K
S
L
H
R
H
N
V
R
L
R
I
I
G
D
T
S
R
F
N
S
R
L
Q
E
R
I
R
K
S
E
A
L
T
A
G
N
T
G
L
T
L
N
I
A
A
N
Y
G
G
R
W
D
I
V
Q
G
V
R
Q
L
A
-
E
K
V
Q
Q
GNL
Q
P
D
-
Q
I
D
------
E
E
M
-
L
N
Q
H
V
C
M
-
H
E
L
A
----
P
V
D
L
V
I
R
T
G
G
E
H
R
I
S
N
F
L
L
W
Q
I
A
Y
A
E
L
Y
F
T
D
V
L
W
P
D
F
D
E
Q
D
F
E
G
A
L
N
A
F
A
N
R
---------
61
PsiBlast_CBE
81.32
37%
-84
- C8 -
2VG2
5
DPDS_MYCTU
D:
[53-282]
-
D
R
L
P
N
H
V
A
I
V
M
-
D
G
N
G
R
W
A
T
Q
R
G
L
A
R
T
E
G
H
K
M
G
E
A
V
V
I
D
I
A
C
G
A
I
E
L
G
I
K
W
L
S
L
Y
A
F
S
-
T
E
N
W
K
R
S
P
E
E
V
R
F
L
M
G
F
N
R
D
V
V
R
R
R
R
D
T
L
K
K
L
G
V
R
I
R
W
V
G
S
R
P
R
L
W
R
S
V
I
N
E
L
A
V
A
E
E
M
T
K
S
N
D
V
I
T
I
N
Y
C
V
N
Y
G
G
R
T
E
I
T
E
A
T
R
E
I
A
R
E
V
------
A
A
G
-
R
L
N
P
E
R
I
T
-
E
S
T
-
I
A
R
H
L
Q
R
-
P
D
I
P
----
D
V
D
L
F
L
R
T
S
G
E
Q
R
S
S
N
F
M
L
W
Q
A
A
Y
A
E
Y
I
F
Q
D
K
L
W
P
D
Y
D
R
R
D
L
W
A
A
C
E
E
Y
A
S
R
T
R
R
F
G
S
A
--
58
PsiBlast_CBE
81.16
37%
-83
- C8 -
2VG3
6
DPDS_MYCTU
C:
[53-282]
-
D
R
L
P
N
H
V
A
I
V
M
-
D
G
N
G
R
W
A
T
Q
R
G
L
A
R
T
E
G
H
K
M
G
E
A
V
V
I
D
I
A
C
G
A
I
E
L
G
I
K
W
L
S
L
Y
A
F
S
-
T
E
N
W
K
R
S
P
E
E
V
R
F
L
M
G
F
N
R
D
V
V
R
R
R
R
D
T
L
K
K
L
G
V
R
I
R
W
V
G
S
R
P
R
L
W
R
S
V
I
N
E
L
A
V
A
E
E
M
T
K
S
N
D
V
I
T
I
N
Y
C
V
N
Y
G
G
R
T
E
I
T
E
A
T
R
E
I
A
R
E
V
------
A
A
G
-
R
L
N
P
E
R
I
T
-
E
S
T
-
I
A
R
H
L
Q
R
-
P
D
I
P
----
D
V
D
L
F
L
R
T
S
G
E
Q
R
S
S
N
F
M
L
W
Q
A
A
Y
A
E
Y
I
F
Q
D
K
L
W
P
D
Y
D
R
R
D
L
W
A
A
C
E
E
Y
A
S
R
T
R
R
F
G
S
A
--
44
PsiBlast_CBE
81.16
41%
-108
- C8 -
3UGS
2
ISPT_CAMJE
B:
[7-224]
----
L
K
H
L
A
V
V
M
-
D
G
N
R
--------------
S
Q
G
V
K
T
M
Q
K
L
M
E
V
C
M
E
E
N
I
S
N
L
S
L
F
A
F
S
-
T
E
N
W
K
R
P
K
D
E
I
D
F
I
F
E
L
L
D
R
C
L
D
E
A
L
E
K
F
E
K
N
N
V
R
L
R
A
I
G
D
L
S
R
L
E
D
K
V
R
E
K
I
T
L
V
E
E
K
T
K
H
C
D
A
L
C
V
N
L
A
I
S
Y
G
A
R
D
E
I
I
R
A
A
K
R
V
I
-
E
K
------
K
-------
L
E
L
N
-
E
E
N
-
L
T
Q
N
L
----
D
L
P
L---
D
V
D
L
M
L
R
V
G
N
A
K
R
L
S
N
F
L
L
W
Q
C
S
Y
A
E
I
Y
F
S
E
T
L
F
P
S
L
T
K
R
E
F
K
R
I
I
K
E
F
R
N
R
E
R
T
F
G
K
---
15
PsiBlast_PDB
81.01
42%
-100
- C8 -
3SGV
2
UPPS_ECOLI
B:
[19-240]
-----
R
H
V
A
I
I
M
-
D
G
N
G
R
W
A
K
K
Q
G
K
I
R
A
F
G
H
K
A
G
A
K
S
V
R
R
A
V
S
F
A
A
N
N
G
I
E
A
L
T
L
Y
A
F
------------
V
S
A
L
M
E
L
F
V
W
A
L
D
S
E
V
K
S
L
H
R
H
N
V
R
L
R
I
I
G
D
T
S
R
F
N
S
R
L
Q
E
R
I
R
K
S
E
A
L
T
A
G
N
T
G
L
T
L
N
I
A
A
N
Y
G
G
R
W
D
I
V
Q
G
V
R
Q
L
A
-
E
K
V
Q
Q
GNL
Q
P
D
-
Q
I
D
------
E
E
M
-
L
N
Q
H
V
C
M
-
H
E
L
A
----
P
V
D
L
V
I
R
T
G
G
E
H
R
I
S
N
F
L
L
W
Q
I
A
Y
A
E
L
Y
F
T
D
V
L
W
P
D
F
D
E
Q
D
F
E
G
A
L
N
A
F
A
N
R
E
--------
60
PsiBlast_CBE
80.87
37%
-81
- C8 -
2VG3
6
DPDS_MYCTU
A:
[53-282]
-
D
R
L
P
N
H
V
A
I
V
M
-
D
G
N
G
R
W
A
T
Q
R
G
L
A
R
T
E
G
H
K
M
G
E
A
V
V
I
D
I
A
C
G
A
I
E
L
G
I
K
W
L
S
L
Y
A
F
S
-
T
E
N
W
K
R
S
P
E
E
V
R
F
L
M
G
F
N
R
D
V
V
R
R
R
R
D
T
L
K
K
L
G
V
R
I
R
W
V
G
S
R
P
R
L
W
R
S
V
I
N
E
L
A
V
A
E
E
M
T
K
S
N
D
V
I
T
I
N
Y
C
V
N
Y
G
G
R
T
E
I
T
E
A
T
R
E
I
A
R
E
V
------
A
A
G
-
R
L
N
P
E
R
I
T
-
E
S
T
-
I
A
R
H
L
Q
R
-
P
D
I
P
----
D
V
D
L
F
L
R
T
S
G
E
Q
R
S
S
N
F
M
L
W
Q
A
A
Y
A
E
Y
I
F
Q
D
K
L
W
P
D
Y
D
R
R
D
L
W
A
A
C
E
E
Y
A
S
R
T
R
R
F
G
S
A
--
8
PsiBlast_PDB
80.80
42%
-87
- C8 -
2E99
3
UPPS_ECOLI
A:
[19-240]
-----
R
H
V
A
I
I
M
-
D
G
N
G
R
W
A
K
K
Q
G
K
I
R
A
F
G
H
K
A
G
A
K
S
V
R
R
A
V
S
F
A
A
N
N
G
I
E
A
L
T
L
Y
A
F
S
-
S
E
N
W
N
R
P
A
Q
E
V
S
A
L
M
E
L
F
V
W
A
L
D
S
E
V
K
S
L
H
R
H
N
V
R
L
R
I
I
G
D
T
S
R
F
N
S
R
L
Q
E
R
I
R
K
S
E
A
L
T
A
G
N
T
G
L
T
L
N
I
A
A
N
Y
G
G
R
W
D
I
V
Q
G
V
R
Q
L
A
-
E
K
V
Q
Q
GNL
Q
P
D
-
Q
I
D
------
E
E
M
-
L
N
Q
H
V
C
M
-
H
E
L
A
----
P
V
D
L
V
I
R
T
G
G
E
H
R
I
S
N
F
L
L
W
Q
I
A
Y
A
E
L
Y
F
T
D
V
L
W
P
D
F
D
E
Q
D
F
E
G
A
L
N
A
F
A
N
R
E
--------
57
PsiBlast_CBE
80.78
37%
-85
- C8 -
2VG3
3
DPDS_MYCTU
D:
[53-282]
-
D
R
L
P
N
H
V
A
I
V
M
-
D
G
N
G
R
W
A
T
Q
R
G
L
A
R
T
E
G
H
K
M
G
E
A
V
V
I
D
I
A
C
G
A
I
E
L
G
I
K
W
L
S
L
Y
A
F
S
-
T
E
N
W
K
R
S
P
E
E
V
R
F
L
M
G
F
N
R
D
V
V
R
R
R
R
D
T
L
K
K
L
G
V
R
I
R
W
V
G
S
R
P
R
L
W
R
S
V
I
N
E
L
A
V
A
E
E
M
T
K
S
N
D
V
I
T
I
N
Y
C
V
N
Y
G
G
R
T
E
I
T
E
A
T
R
E
I
A
R
E
V
------
A
A
G
-
R
L
N
P
E
R
I
T
-
E
S
T
-
I
A
R
H
L
Q
R
-
P
D
I
P
----
D
V
D
L
F
L
R
T
S
G
E
Q
R
S
S
N
F
M
L
W
Q
A
A
Y
A
E
Y
I
F
Q
D
K
L
W
P
D
Y
D
R
R
D
L
W
A
A
C
E
E
Y
A
S
R
T
R
R
F
G
S
A
--
84
HHSearch
80.73
42%
-100
- C8 -
3UGS
2
ISPT_CAMJE
B:
[4-225]
-
M
N
E
L
K
H
L
A
V
V
M
-
D
G
N
R
--------------
S
Q
G
V
K
T
M
Q
K
L
M
E
V
C
M
E
E
N
I
S
N
L
S
L
F
A
F
S
-
T
E
N
W
K
R
P
K
D
E
I
D
F
I
F
E
L
L
D
R
C
L
D
E
A
L
E
K
F
E
K
N
N
V
R
L
R
A
I
G
D
L
S
R
L
E
D
K
V
R
E
K
I
T
L
V
E
E
K
T
K
H
C
D
A
L
C
V
N
L
A
I
S
Y
G
A
R
D
E
I
I
R
A
A
K
R
V
I
-
E
K
------
K
--------
L
E
L
N
E
E
N
-
L
T
Q
N
L
D
L
---
P
L
----
D
V
D
L
M
L
R
V
G
N
A
K
R
L
S
N
F
L
L
W
Q
C
S
Y
A
E
I
Y
F
S
E
T
L
F
P
S
L
T
K
R
E
F
K
R
I
I
K
E
F
R
N
R
E
R
T
F
G
K
---
63
PsiBlast_CBE
80.59
37%
-81
- C8 -
2VG2
6
DPDS_MYCTU
B:
[53-282]
-
D
R
L
P
N
H
V
A
I
V
M
-
D
G
N
G
R
W
A
T
Q
R
G
L
A
R
T
E
G
H
K
M
G
E
A
V
V
I
D
I
A
C
G
A
I
E
L
G
I
K
W
L
S
L
Y
A
F
S
-
T
E
N
W
K
R
S
P
E
E
V
R
F
L
M
G
F
N
R
D
V
V
R
R
R
R
D
T
L
K
K
L
G
V
R
I
R
W
V
G
S
R
P
R
L
W
R
S
V
I
N
E
L
A
V
A
E
E
M
T
K
S
N
D
V
I
T
I
N
Y
C
V
N
Y
G
G
R
T
E
I
T
E
A
T
R
E
I
A
R
E
V
------
A
A
G
-
R
L
N
P
E
R
I
T
-
E
S
T
-
I
A
R
H
L
Q
R
-
P
D
I
P
----
D
V
D
L
F
L
R
T
S
G
E
Q
R
S
S
N
F
M
L
W
Q
A
A
Y
A
E
Y
I
F
Q
D
K
L
W
P
D
Y
D
R
R
D
L
W
A
A
C
E
E
Y
A
S
R
T
R
R
F
G
S
---
59
PsiBlast_CBE
80.53
37%
-81
- C8 -
2VG3
7
DPDS_MYCTU
B:
[53-282]
-
D
R
L
P
N
H
V
A
I
V
M
-
D
G
N
G
R
W
A
T
Q
R
G
L
A
R
T
E
G
H
K
M
G
E
A
V
V
I
D
I
A
C
G
A
I
E
L
G
I
K
W
L
S
L
Y
A
F
S
-
T
E
N
W
K
R
S
P
E
E
V
R
F
L
M
G
F
N
R
D
V
V
R
R
R
R
D
T
L
K
K
L
G
V
R
I
R
W
V
G
S
R
P
R
L
W
R
S
V
I
N
E
L
A
V
A
E
E
M
T
K
S
N
D
V
I
T
I
N
Y
C
V
N
Y
G
G
R
T
E
I
T
E
A
T
R
E
I
A
R
E
V
------
A
A
G
-
R
L
N
P
E
R
I
T
-
E
S
T
-
I
A
R
H
L
Q
R
-
P
D
I
P
----
D
V
D
L
F
L
R
T
S
G
E
Q
R
S
S
N
F
M
L
W
Q
A
A
Y
A
E
Y
I
F
Q
D
K
L
W
P
D
Y
D
R
R
D
L
W
A
A
C
E
E
Y
A
S
R
T
R
R
F
G
S
A
--
45
PsiBlast_CBE
80.52
41%
-114
- C8 -
3UGS
2
ISPT_CAMJE
A:
[7-224]
----
L
K
H
L
A
V
V
M
-
D
G
N
R
----------------
G
V
K
T
M
Q
K
L
M
E
V
C
M
E
E
N
I
S
N
L
S
L
F
A
F
S
-
T
E
N
W
K
R
P
K
D
E
I
D
F
I
F
E
L
L
D
R
C
L
D
E
A
L
E
K
F
E
K
N
N
V
R
L
R
A
I
G
D
L
S
R
L
E
D
K
V
R
E
K
I
T
L
V
E
E
K
T
K
H
C
D
A
L
C
V
N
L
A
I
S
Y
G
A
R
D
E
I
I
R
A
A
K
R
V
I
-
E
K
------
K
-------
L
E
L
N
-
E
E
N
-
L
T
Q
N
L
----
D
L
P
L---
D
V
D
L
M
L
R
V
G
N
A
K
R
L
S
N
F
L
L
W
Q
C
S
Y
A
E
I
Y
F
S
E
T
L
F
P
S
L
T
K
R
E
F
K
R
I
I
K
E
F
R
N
R
E
R
T
F
G
----
7
PsiBlast_PDB
80.27
42%
-93
- C8 -
2E98
4
UPPS_ECOLI
A:
[19-240]
-----
R
H
V
A
I
I
M
-
D
G
N
G
R
W
A
K
K
Q
G
K
I
R
A
F
G
H
K
A
G
A
K
S
V
R
R
A
V
S
F
A
A
N
N
G
I
E
A
L
T
L
Y
A
F
S
-
S
E
N
W
N
R
P
A
Q
E
V
S
A
L
M
E
L
F
V
W
A
L
D
S
E
V
K
S
L
H
R
H
N
V
R
L
R
I
I
G
D
T
S
R
F
N
S
R
L
Q
E
R
I
R
K
S
E
A
L
T
A
G
N
T
G
L
T
L
N
I
A
A
N
Y
G
G
R
W
D
I
V
Q
G
V
R
Q
L
A
-
E
K
V
Q
Q
GNL
Q
P
D
-
Q
I
D
------
E
E
M
-
L
N
Q
H
V
C
M
-
H
E
L
A
----
P
V
D
L
V
I
R
T
G
G
E
H
R
I
S
N
F
L
L
W
Q
I
A
Y
A
E
L
Y
F
T
D
V
L
W
P
D
F
D
E
Q
D
F
E
G
A
L
N
A
F
A
N
R
E
--------
16
PsiBlast_PDB
80.26
42%
-95
- C8 -
3SGX
2
UPPS_ECOLI
A:
[19-238]
-----
R
H
V
A
I
I
M
-
D
G
N
G
R
W
A
K
K
Q
G
K
I
R
A
F
G
H
K
A
G
A
K
S
V
R
R
A
V
S
F
A
A
N
N
G
I
E
A
L
T
L
Y
A
F
S
-
S
E
-----------
L
M
E
L
F
V
W
A
L
D
S
E
V
K
S
L
H
R
H
N
V
R
L
R
I
I
G
D
T
S
R
F
N
S
R
L
Q
E
R
I
R
K
S
E
A
L
T
A
G
N
T
G
L
T
L
N
I
A
A
N
Y
G
G
R
W
D
I
V
Q
G
V
R
Q
L
A
-
E
K
V
Q
Q
GNL
Q
P
D
-
Q
I
D
------
E
E
M
-
L
N
Q
H
V
C
M
-
H
E
L
A
----
P
V
D
L
V
I
R
T
G
G
E
H
R
I
S
N
F
L
L
W
Q
I
A
Y
A
E
L
Y
F
T
D
V
L
W
P
D
F
D
E
Q
D
F
E
G
A
L
N
A
F
A
N
----------
11
PsiBlast_PDB
79.87
42%
-94
- C8 -
2E9D
2
UPPS_ECOLI
A:
[19-240]
-----
R
H
V
A
I
I
M
-
D
G
N
G
R
W
A
K
K
Q
G
K
I
R
A
F
G
H
K
A
G
A
K
S
V
R
R
A
V
S
F
A
A
N
N
G
I
E
A
L
T
L
Y
A
F
S
--------
A
Q
E
V
S
A
L
M
E
L
F
V
W
A
L
D
S
E
V
K
S
L
H
R
H
N
V
R
L
R
I
I
G
D
T
S
R
F
N
S
R
L
Q
E
R
I
R
K
S
E
A
L
T
A
G
N
T
G
L
T
L
N
I
A
A
N
Y
G
G
R
W
D
I
V
Q
G
V
R
Q
L
A
-
E
K
V
Q
Q
GNL
Q
P
D
-
Q
I
D
------
E
E
M
-
L
N
Q
H
V
C
M
-
H
E
L
A
----
P
V
D
L
V
I
R
T
G
G
E
H
R
I
S
N
F
L
L
W
Q
I
A
Y
A
E
L
Y
F
T
D
V
L
W
P
D
F
D
E
Q
D
F
E
G
A
L
N
A
F
A
N
R
E
--------
54
PsiBlast_CBE
79.72
37%
-81
- C8 -
4Q9M
12
ISPT_STRR6
A:
[16-240]
------
H
I
G
I
I
M
-
D
G
N
G
R
W
A
K
K
R
M
Q
P
R
V
F
G
H
K
A
G
M
E
A
L
Q
T
V
T
K
A
A
N
K
L
G
V
K
V
I
T
V
Y
A
F
S
-
T
E
N
W
T
R
P
D
Q
E
V
K
F
I
M
N
L
P
V
E
F
Y
D
N
Y
V
P
E
L
H
A
N
N
V
K
I
Q
M
I
G
E
T
D
R
L
P
K
Q
T
F
E
A
L
T
K
A
E
E
L
T
K
N
N
T
G
L
I
L
N
F
A
L
N
Y
G
G
R
A
E
I
T
Q
A
L
K
L
I
S
-
Q
D
------
V
L
D
A
K
I
N
P
G
D
I
T
-
E
E
L
-
I
G
N
Y
L
F
T
-
Q
H
L
P
KDLR
D
P
D
L
I
I
R
T
S
G
E
L
R
L
S
N
F
L
P
W
Q
G
A
Y
S
E
L
Y
F
T
D
T
L
W
P
D
F
D
E
A
A
L
Q
E
A
I
L
A
Y
N
R
R
H
--------
24
PsiBlast_CBE
79.62
42%
-94
- C8 -
4H3C
2
UPPS_ECOLI
A:
[19-239]
-----
R
H
V
A
I
I
M
-
D
G
N
G
R
W
A
K
K
Q
G
K
I
R
A
F
G
H
K
A
G
A
K
S
V
R
R
A
V
S
F
A
A
N
N
G
I
E
A
L
T
L
Y
A
F
----------------
M
E
L
F
V
W
A
L
D
S
E
V
K
S
L
H
R
H
N
V
R
L
R
I
I
G
D
T
S
R
F
N
S
R
L
Q
E
R
I
R
K
S
E
A
L
T
A
G
N
T
G
L
T
L
N
I
A
A
N
Y
G
G
R
W
D
I
V
Q
G
V
R
Q
L
A
-
E
K
V
Q
Q
GNL
Q
P
D
-
Q
I
D
------
E
E
M
-
L
N
Q
H
V
C
M
-
H
E
L
A
----
P
V
D
L
V
I
R
T
G
G
E
H
R
I
S
N
F
L
L
W
Q
I
A
Y
A
E
L
Y
F
T
D
V
L
W
P
D
F
D
E
Q
D
F
E
G
A
L
N
A
F
A
N
R
---------
31
PsiBlast_CBE
79.52
42%
-90
- C8 -
3TH8
1
UPPS_ECOLI
B:
[19-239]
-----
R
H
V
A
I
I
M
-
D
G
N
G
R
W
A
K
K
Q
G
K
I
R
A
F
G
H
K
A
G
A
K
S
V
R
R
A
V
S
F
A
A
N
N
G
I
E
A
L
T
L
Y
A
F
----------------
M
E
L
F
V
W
A
L
D
S
E
V
K
S
L
H
R
H
N
V
R
L
R
I
I
G
D
T
S
R
F
N
S
R
L
Q
E
R
I
R
K
S
E
A
L
T
A
G
N
T
G
L
T
L
N
I
A
A
N
Y
G
G
R
W
D
I
V
Q
G
V
R
Q
L
A
-
E
K
V
Q
Q
GNL
Q
P
D
-
Q
I
D
------
E
E
M
-
L
N
Q
H
V
C
M
-
H
E
L
A
----
P
V
D
L
V
I
R
T
G
G
E
H
R
I
S
N
F
L
L
W
Q
I
A
Y
A
E
L
Y
F
T
D
V
L
W
P
D
F
D
E
Q
D
F
E
G
A
L
N
A
F
A
N
R
---------
83
HHSearch
79.46
37%
-79
- C8 -
2VG3
6
DPDS_MYCTU
A:
[53-284]
-
D
R
L
P
N
H
V
A
I
V
M
-
D
G
N
G
R
W
A
T
Q
R
G
L
A
R
T
E
G
H
K
M
G
E
A
V
V
I
D
I
A
C
G
A
I
E
L
G
I
K
W
L
S
L
Y
A
F
S
-
T
E
N
W
K
R
S
P
E
E
V
R
F
L
M
G
F
N
R
D
V
V
R
R
R
R
D
T
L
K
K
L
G
V
R
I
R
W
V
G
S
R
P
R
L
W
R
S
V
I
N
E
L
A
V
A
E
E
M
T
K
S
N
D
V
I
T
I
N
Y
C
V
N
Y
G
G
R
T
E
I
T
E
A
T
R
E
I
A
-
R
E
------
V
A
A
-
G
R
L
N
P
E
R
I
T
E
S
T
-
I
A
R
H
L
Q
R
-
P
D
I
P
----
D
V
D
L
F
L
R
T
S
G
E
Q
R
S
S
N
F
M
L
W
Q
A
A
Y
A
E
Y
I
F
Q
D
K
L
W
P
D
Y
D
R
R
D
L
W
A
A
C
E
E
Y
A
S
R
T
R
R
F
G
S
A
--
53
PsiBlast_CBE
79.26
37%
-83
- C8 -
4Q9M
8
ISPT_STRR6
B:
[16-239]
------
H
I
G
I
I
M
-
D
G
N
G
R
W
A
K
K
R
M
Q
P
R
V
F
G
H
K
A
G
M
E
A
L
Q
T
V
T
K
A
A
N
K
L
G
V
K
V
I
T
V
Y
A
F
S
-
T
E
N
W
T
R
P
D
Q
E
V
K
F
I
M
N
L
P
V
E
F
Y
D
N
Y
V
P
E
L
H
A
N
N
V
K
I
Q
M
I
G
E
T
D
R
L
P
K
Q
T
F
E
A
L
T
K
A
E
E
L
T
K
N
N
T
G
L
I
L
N
F
A
L
N
Y
G
G
R
A
E
I
T
Q
A
L
K
L
I
S
-
Q
D
------
V
L
D
A
K
I
N
P
G
D
I
T
-
E
E
L
-
I
G
N
Y
L
F
T
-
Q
H
L
P
KDLR
D
P
D
L
I
I
R
T
S
G
E
L
R
L
S
N
F
L
P
W
Q
G
A
Y
S
E
L
Y
F
T
D
T
L
W
P
D
F
D
E
A
A
L
Q
E
A
I
L
A
Y
N
R
R
---------
9
PsiBlast_PDB
79.25
42%
-95
- C8 -
2E9A
2
UPPS_ECOLI
A:
[19-240]
-----
R
H
V
A
I
I
M
-
D
G
N
G
R
W
A
K
K
Q
G
K
I
R
A
F
G
H
K
A
G
A
K
S
V
R
R
A
V
S
F
A
A
N
N
G
I
E
A
L
T
L
Y
A
F
S
-
S
---------
V
S
A
L
M
E
L
F
V
W
A
L
D
S
E
V
K
S
L
H
R
H
N
V
R
L
R
I
I
G
D
T
S
R
F
N
S
R
L
Q
E
R
I
R
K
S
E
A
L
T
A
G
N
T
G
L
T
L
N
I
A
A
N
Y
G
G
R
W
D
I
V
Q
G
V
R
Q
L
A
-
E
K
V
Q
Q
GNL
Q
P
D
-
Q
I
D
------
E
E
M
-
L
N
Q
H
V
C
M
-
H
E
L
A
----
P
V
D
L
V
I
R
T
G
G
E
H
R
I
S
N
F
L
L
W
Q
I
A
Y
A
E
L
Y
F
T
D
V
L
W
P
D
F
D
E
Q
D
F
E
G
A
L
N
A
F
A
N
R
E
--------
20
PsiBlast_PDB
79.21
42%
-90
- C8 -
4H2O
2
UPPS_ECOLI
B:
[19-239]
-----
R
H
V
A
I
I
M
-
D
G
N
G
R
W
A
K
K
Q
G
K
I
R
A
F
G
H
K
A
G
A
K
S
V
R
R
A
V
S
F
A
A
N
N
G
I
E
A
L
T
L
Y
A
F
S
-
S
----------------
F
V
W
A
L
D
S
E
V
K
S
L
H
R
H
N
V
R
L
R
I
I
G
D
T
S
R
F
N
S
R
L
Q
E
R
I
R
K
S
E
A
L
T
A
G
N
T
G
L
T
L
N
I
A
A
N
Y
G
G
R
W
D
I
V
Q
G
V
R
Q
L
A
-
E
K
V
Q
Q
G--
Q
P
D
-
Q
I
D
------
E
E
M
-
L
N
Q
H
V
C
M
-
H
E
L
A
----
P
V
D
L
V
I
R
T
G
G
E
H
R
I
S
N
F
L
L
W
Q
I
A
Y
A
E
L
Y
F
T
D
V
L
W
P
D
F
D
E
Q
D
F
E
G
A
L
N
A
F
A
N
R
---------
10
PsiBlast_PDB
79.08
42%
-97
- C8 -
2E9C
3
UPPS_ECOLI
A:
[19-240]
-----
R
H
V
A
I
I
M
-
D
G
N
G
R
W
A
K
K
Q
G
K
I
R
A
F
G
H
K
A
G
A
K
S
V
R
R
A
V
S
F
A
A
N
N
G
I
E
A
L
T
L
Y
A
F
S
-
S
E
-------------------
L
D
S
E
V
K
S
L
H
R
H
N
V
R
L
R
I
I
G
D
T
S
R
F
N
S
R
L
Q
E
R
I
R
K
S
E
A
L
T
A
G
N
T
G
L
T
L
N
I
A
A
N
Y
G
G
R
W
D
I
V
Q
G
V
R
Q
L
A
-
E
K
V
Q
Q
GNL
Q
P
D
-
Q
I
D
------
E
E
M
-
L
N
Q
H
V
C
M
-
H
E
L
A
----
P
V
D
L
V
I
R
T
G
G
E
H
R
I
S
N
F
L
L
W
Q
I
A
Y
A
E
L
Y
F
T
D
V
L
W
P
D
F
D
E
Q
D
F
E
G
A
L
N
A
F
A
N
R
E
--------
41
PsiBlast_CBE
78.23
42%
-96
- C8 -
5CQB
1
?
A:
[18-238]
-----
R
H
V
A
I
I
M
-
D
G
N
G
R
W
A
K
K
Q
G
K
I
R
A
F
G
H
K
A
G
A
K
S
V
R
R
A
V
S
F
A
A
N
N
G
I
E
A
L
T
L
Y
A
F
-------------------
F
V
W
A
L
D
S
E
V
K
S
L
H
R
H
N
V
R
L
R
I
I
G
D
T
S
R
F
N
S
R
L
Q
E
R
I
R
K
S
E
A
L
T
A
G
N
T
G
L
T
L
N
I
A
A
N
Y
G
G
R
W
D
I
V
Q
G
V
R
Q
L
A
-
E
K
V
Q
Q
GNL
Q
P
D
-
Q
I
D
------
E
E
M
-
L
N
Q
H
V
C
M
-
H
E
L
A
----
P
V
D
L
V
I
R
T
G
G
E
H
R
I
S
N
F
L
L
W
Q
I
A
Y
A
E
L
Y
F
T
D
V
L
W
P
D
F
D
E
Q
D
F
E
G
A
L
N
A
F
A
N
R
---------
72
Fugue
78.01
39%
-81
- C8 -
1JP3
1
UPPS_ECOLI
A:
[13-240]
L
P
A
H
G
C
R
H
V
A
I
I
M
D
G
N
G
R
W
A
K
K
Q
G
K
I
R
A
F
G
H
K
A
G
A
K
S
V
R
R
A
V
S
F
A
A
N
N
G
I
E
A
L
T
L
Y
A
F
S
M
E
L
F
V
W
A
L
D
S
E
V
K
S
L
H
R
---------------
H
N
V
R
L
R
I
I
G
D
T
S
R
F
N
S
R
L
Q
E
R
I
R
K
S
E
A
L
T
A
G
N
T
G
L
T
L
N
I
A
A
N
Y
G
G
R
W
D
I
V
Q
G
V
R
Q
L
A
-
E
K
------
V
Q
Q
-
G
N
L
Q
P
D
Q
I
-
D
E
E
M
L
N
Q
H
V
-
C
M
H
E
L
A
----
P
V
D
L
V
I
R
T
G
G
E
H
R
I
S
N
F
L
L
W
Q
I
A
Y
A
E
L
Y
F
T
D
V
L
W
P
D
F
D
E
Q
D
F
E
G
A
L
N
A
F
A
N
R
E
--------