@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_1150: (2015-12-21 )
MLIVQKYGGTSMGSIERIHNVAQRVLESVKLGHQVVVVVSAMSGETDRLLEFGKNFSHNPNKREMDRIVSAGEWISSAALSMALERYGHRAISLSGKEAGILTSSHFQNAVIQSIDTQRITELLEKNYIVVIAGFQGADIQGETTTLGRGGSDLSAVALAGALKAHLCEIYTDVDGVYTTDPRIEEKAQKIAQISYDEMLELASMGAKVLLNRSVELAKKLSVKLVTRNSFNHSEGTLIVAEKDFKGERMETPIVSGIALDKNQARVSMEGVEDRPGIAAEIFGALAEYRINVDMIVQTIGRDGKTDLDFTIVKTQIEETKQALKPFLAQMDSIDYDENIAKVSIVGVGMKSHSGVASIAFKALAKDNINIMMISTSEIKISVLIDIKYAELAVRTLHAVYQLDQ
Atome Classification :
(26 SA)
.........10........20........30........40........50..----------------------------....---------------------------------------------------------..60--------------------------------------------------------.-----------------------........70........80........90........100.......110.....-.-..120......-----.130.....-..140.-.......150.......160.......170.......180.......190.......200.......210.......220.......230-.-.-.....240----......--.-250.......260.......--270-..--......280.......290.......300-.--.......310.....---..320.---.-------....-------.330-----.--.--..---.------....340.......350.......360.......370...--.--...380.......390.......400...-------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
L
I
V
QKYGGTSMG
S
I
E
R
I
H
N
V
A
Q
R
V
L
E
S
V
KLG
H
Q
V
V
V
V
V
S
AMSG
E
T
D
R
L
L
E
F
G
----------------------------KNFS---------------------------------------------------------HNP---------------------------------------------------------
N
-----------------------
K
R
E
M
D
R
I
V
S
A
G
E
W
I
S
S
A
A
L
S
M
A
L
E
R
YGH
R
A
I
SLSGKE
A
G
I
L
T
S
S
H
F
Q
N
A
-
V
I
Q
SI
D
-
T
-
Q
R
I
T
E
L
L
EKN
Y
-----
I
V
V
I
AGFQG-ADIQ-G-ETTTLGRGGS
D
L
S
A
V
A
L
A
G
A
L
K
A
H
L
C
E
I
Y
TDVDGVYTTDP
R
I
E
E
K
A
Q
K
I
A
QI
S
Y
D
E
M
L
E
L
A
SM
G
A
K
V
L
L
NR
S
V
E
L
A
K
K
L
S
V
K
L
V
TRNSFN-H-S-E
G
T
L
I
V
A
E----KDFKGE--R-METPIVS
G
I
ALDKNQ
A
R
V
SM--EG--VE--DRP
G
I
A
A
E
I
F
G
A
L
A
E
Y
R
I
N
V
D
M
I
V
Q
T
IG--R--DGKTD
L
D
F
T
I
V
K
T
Q
I
---
E
E
T
K
Q
A
---
L
-------
K
P
F
L
-------
A
Q
-------M--D--SI---D------YDEN
I
A
K
V
S
I
V
G
V
GMKSHS
G
V
A
S
I
A
F
K
A
LAKDN
I
N
I
M
M
I
S--T--S
E
I
K
I
S
V
L
I
D
I
K
Y
A
E
L
A
V
R
T
L
H
A
V
Y
QLDQ-------
22
PsiBlast_CBE
95.71
46%
-115
- C2 -
3AB2
2
AK_CORGL
E:
[3-407]
-
L
V
V
Q
K
Y
G
G
S
S
L
E
S
A
E
R
I
R
N
V
A
E
R
I
V
A
T
K
K
A
G
N
D
V
V
V
V
C
S
A
M
G
D
T
T
D
E
L
L
E
L
A
----------------------------
A
A
V
N
---------------------------------------------------------
P
V
P
---------------------------------------------------------
P
-----------------------
A
R
E
M
D
M
L
L
T
A
G
E
R
I
S
N
A
L
V
A
M
A
I
E
S
L
G
A
E
A
Q
S
F
T
G
S
Q
A
G
V
L
T
------------
V
T
-
P
-
G
R
V
R
E
A
L
D
E
G
K
-----
I
C
I
V
A
G
F
Q
---------------
R
G
G
S
D
T
T
A
V
A
L
A
A
A
L
N
A
D
V
C
E
I
Y
S
D
V
D
G
V
Y
T
A
D
P
R
I
V
P
N
A
Q
K
L
E
K
L
S
F
E
E
M
L
E
L
A
A
V
G
S
K
I
L
V
L
R
S
V
E
Y
A
R
A
F
N
V
P
L
R
V
R
S
S
Y
S
-
N
-
D
-
P
G
T
L
I
A
G
S
M---
E
D
I
P
------
V
E
E
A
V
L
T
G
V
A
T
D
K
S
E
A
K
V
T
V
--
L
G
--
I
S
--
D
K
P
G
E
A
A
K
V
F
R
A
L
A
D
A
E
I
N
I
D
M
V
L
Q
N
V
S
SV
E
--
D
G
T
T
D
I
T
F
T
C
P
R
S
D
G
---
R
R
A
M
E
I
---
L
-------
K
K
L
Q
-------
V
Q
-------
G
--
N
WT
N
V
---
L
------
Y
D
D
Q
V
G
K
V
S
L
V
G
A
G
M
K
S
H
P
G
V
T
A
E
F
M
E
A
L
R
D
V
N
V
N
I
E
L
I
S
--
T
--
S
E
I
R
I
S
V
L
I
R
E
D
D
L
D
A
A
A
R
A
L
H
E
Q
F
Q
L
G
--------
23
PsiBlast_CBE
95.22
46%
-119
- C2 -
3AAW
4
AK_CORGL
C:
[3-407]
-
L
V
V
Q
K
Y
G
G
S
S
L
E
S
A
E
R
I
R
N
V
A
E
R
I
V
A
T
K
K
A
G
N
D
V
V
V
V
C
S
A
M
G
D
T
T
D
E
L
L
E
L
A
----------------------------
A
A
V
N
---------------------------------------------------------
P
V
P
---------------------------------------------------------
P
-----------------------
A
R
E
M
D
M
L
L
T
A
G
E
R
I
S
N
A
L
V
A
M
A
I
E
S
L
G
A
E
A
Q
S
F
T
G
S
Q
----------------
D
V
T
-
P
-
G
R
V
R
E
A
L
D
E
G
K
-----
I
C
I
V
A
G
F
Q
G
-
V
N
K
---R
D
V
T
T
L
G
R
G
G
S
D
T
T
A
V
A
L
A
A
A
L
N
A
D
V
C
E
I
Y
S
D
V
D
G
V
Y
T
A
D
P
R
I
V
P
N
A
Q
K
L
E
K
L
S
F
E
E
M
L
E
L
A
A
V
G
S
K
I
L
V
L
R
S
V
E
Y
A
R
A
F
N
V
P
L
R
V
R
S
S
Y
S
-
N
-
D
-
P
G
T
L
I
A
G
S
M---
E
D
I
P
------
V
E
E
A
V
L
T
G
V
A
T
D
K
S
E
A
K
V
T
V
--
L
G
--
I
S
--
D
K
P
G
E
A
A
K
V
F
R
A
L
A
D
A
E
I
N
I
D
M
V
L
Q
N
V
S
SV
E
--
D
G
T
T
D
I
T
F
T
C
P
R
S
D
G
---
R
R
A
M
E
I
---
L
-------
K
K
L
Q
-------
V
Q
-------
G
--
N
WT
N
V
---
L
------
Y
D
D
Q
V
G
K
V
S
L
V
G
A
G
M
K
S
H
P
G
V
T
A
E
F
M
E
A
L
R
D
V
N
V
N
I
E
L
I
S
--
T
--
S
E
I
R
I
S
V
L
I
R
E
D
D
L
D
A
A
A
R
A
L
H
E
Q
F
Q
L
G
G
-------
30
PsiBlast_CBE
94.87
46%
-117
- C2 -
3AB4
3
?
C:
[3-407]
-
L
V
V
Q
K
Y
G
G
S
S
L
E
S
A
E
R
I
R
N
V
A
E
R
I
V
A
T
K
K
A
G
N
D
V
V
V
V
C
S
A
M
G
D
T
T
D
E
L
L
E
L
A
----------------------------
A
A
V
N
---------------------------------------------------------
P
V
P
---------------------------------------------------------
P
-----------------------
A
R
E
M
D
M
L
L
T
A
G
E
R
I
S
N
A
L
V
A
M
A
I
E
S
L
G
A
E
A
Q
S
F
T
---------------------
T
-
P
-
G
R
V
R
E
A
L
D
E
G
K
-----
I
C
I
V
A
-------------------
G
G
S
D
T
T
A
V
A
L
A
A
A
L
N
A
D
V
C
E
I
Y
S
D
V
D
G
V
Y
T
A
D
P
R
I
V
P
N
A
Q
K
L
E
K
L
S
F
E
E
M
L
E
L
A
A
V
G
S
K
I
L
V
L
R
S
V
E
Y
A
R
A
F
N
V
P
L
R
V
R
S
S
Y
S
-
N
-
D
-
P
G
T
L
I
A
G
S
M---
E
D
I
P
------
V
E
E
A
V
L
T
G
V
A
T
D
K
S
E
A
K
V
T
V
--
L
G
--
I
S
--
D
K
P
G
E
A
A
K
V
F
R
A
L
A
D
A
E
I
N
I
D
M
V
L
Q
N
V
------
D
G
T
T
D
I
T
F
T
C
P
R
S
D
G
---
R
R
A
M
E
I
---
L
-------
K
K
L
Q
-------
V
Q
-------
G
--
N
WT
N
V
---
L
------
Y
D
D
Q
V
G
K
V
S
L
V
G
A
G
M
K
S
H
P
G
V
T
A
E
F
M
E
A
L
R
D
V
N
V
N
I
E
L
I
S
--
T
--
S
E
I
R
I
S
V
L
I
R
E
D
D
L
D
A
A
A
R
A
L
H
E
Q
F
Q
L
G
G
-------
28
PsiBlast_CBE
94.16
46%
-121
- C2 -
3AB4
1
?
G:
[3-407]
-
L
V
V
Q
K
Y
G
G
S
S
L
E
S
A
E
R
I
R
N
V
A
E
R
I
V
A
T
K
K
A
G
N
D
V
V
V
V
C
S
A
M
G
D
T
T
D
E
L
L
E
L
A
----------------------------
A
A
V
N
---------------------------------------------------------
P
V
P
---------------------------------------------------------
P
-----------------------
A
R
E
M
D
M
L
L
T
A
G
E
R
I
S
N
A
L
V
A
M
A
I
E
S
L
G
A
E
A
Q
S
F
T
--------------------------
R
V
R
E
A
L
D
E
G
K
-----
I
C
I
V
A
-------------------
G
G
S
D
T
T
A
V
A
L
A
A
A
L
N
A
D
V
C
E
I
Y
S
D
V
D
G
V
Y
T
A
D
P
R
I
V
P
N
A
Q
K
L
E
K
L
S
F
E
E
M
L
E
L
A
A
V
G
S
K
I
L
V
L
R
S
V
E
Y
A
R
A
F
N
V
P
L
R
V
R
S
S
Y
S
-
N
-
D
-
P
G
T
L
I
A
G
S
M---
E
D
I
P
------
V
--
A
V
L
T
G
V
A
T
D
K
S
E
A
K
V
T
V
--
L
G
--
I
S
--
D
K
P
G
E
A
A
K
V
F
R
A
L
A
D
A
E
I
N
I
D
M
V
L
Q
N
V
F
-------
T
T
D
I
T
F
T
C
P
R
S
D
G
---
R
R
A
M
E
I
---
L
-------
K
K
L
Q
-------
V
Q
-----------WT
N
V
---
L
------
Y
D
D
Q
V
G
K
V
S
L
V
G
A
G
M
K
S
H
P
G
V
T
A
E
F
M
E
A
L
R
D
V
N
V
N
I
E
L
I
S
--
T
--
S
E
I
R
I
S
V
L
I
R
E
D
D
L
D
A
A
A
R
A
L
H
E
Q
F
Q
L
---------
29
PsiBlast_CBE
94.15
46%
-117
- C2 -
3AB4
3
?
E:
[3-407]
-
L
V
V
Q
K
Y
G
G
S
S
L
E
S
A
E
R
I
R
N
V
A
E
R
I
V
A
T
K
K
A
G
N
D
V
V
V
V
C
S
A
M
G
D
T
T
D
E
L
L
E
L
A
----------------------------
A
A
V
N
---------------------------------------------------------
P
V
P
---------------------------------------------------------
P
-----------------------
A
R
E
M
D
M
L
L
T
A
G
E
R
I
S
N
A
L
V
A
M
A
I
E
S
L
G
A
E
A
Q
S
F
T
G
--------------------
T
-
P
-
G
R
V
R
E
A
L
D
E
G
K
-----
I
C
I
V
A
G
F
--------------
L
G
R
G
G
S
D
T
T
A
V
A
L
A
A
A
L
N
A
D
V
C
E
I
Y
S
D
V
D
G
V
Y
T
A
D
P
R
I
V
P
N
A
Q
K
L
E
K
L
S
F
E
E
M
L
E
L
A
A
V
G
S
K
I
L
V
L
R
S
V
E
Y
A
R
A
F
N
V
P
L
R
V
R
S
S
Y
S
-
N
-
D
-
P
G
T
L
I
A
G
S
M---
E
D
I
P
------
V
E
E
A
V
L
T
G
V
A
T
D
K
S
E
A
K
V
T
V
--
L
G
--
I
S
--
D
K
P
G
E
A
A
K
V
F
R
A
L
A
D
A
E
I
N
I
D
M
V
L
Q
N
---------
T
T
D
I
T
F
T
C
P
R
S
D
G
---
R
R
A
M
E
I
---
L
-------
K
K
L
---------
Q
-------
G
--
N
WT
N
V
---
L
------
Y
D
D
Q
V
G
K
V
S
L
V
G
A
G
M
K
S
H
P
G
V
T
A
E
F
M
E
A
L
R
D
V
N
V
N
I
E
L
I
S
--
T
--
S
E
I
R
I
S
V
L
I
R
E
D
D
L
D
A
A
A
R
A
L
H
E
Q
F
Q
L
G
G
-------
24
PsiBlast_CBE
94.02
46%
-119
- C2 -
3AB4
13
?
O:
[3-407]
-
L
V
V
Q
K
Y
G
G
S
S
L
E
S
A
E
R
I
R
N
V
A
E
R
I
V
A
T
K
K
A
G
N
D
V
V
V
V
C
S
A
M
G
D
T
T
D
E
L
L
E
L
A
----------------------------
A
A
V
N
---------------------------------------------------------
P
V
P
---------------------------------------------------------
P
-----------------------
A
R
E
M
D
M
L
L
T
A
G
E
R
I
S
N
A
L
V
A
M
A
I
E
S
L
G
A
E
A
Q
S
F
T
-------------------
D
V
T
-
P
-
G
R
V
R
E
A
L
D
E
G
K
-----
I
C
I
V
A
------------------
R
G
G
S
D
T
T
A
V
A
L
A
A
A
L
N
A
D
V
C
E
I
Y
S
D
V
D
G
V
Y
T
A
D
P
R
I
V
P
N
A
Q
K
L
E
K
L
S
F
E
E
M
L
E
L
A
A
V
G
S
K
I
L
V
L
R
S
V
E
Y
A
R
A
F
N
V
P
L
R
V
R
S
S
Y
S
-
N
-
D
-
P
G
T
L
I
A
G
S
M---
E
D
I
P
------
V
E
E
A
V
L
T
G
V
A
T
D
K
S
E
A
K
V
T
V
--
L
G
--
I
S
--
D
K
P
G
E
A
A
K
V
F
R
A
L
A
D
A
E
I
N
I
D
M
V
L
Q
N
-------
D
G
T
T
D
I
T
F
T
C
P
R
S
D
G
---
R
R
A
M
E
I
---
L
-------
K
K
----------
Q
-------
G
--
N
WT
N
V
---
L
------
Y
D
D
Q
V
G
K
V
S
L
V
G
A
G
M
K
S
H
P
G
V
T
A
E
F
M
E
A
L
R
D
V
N
V
N
I
E
L
I
S
--
T
--
S
E
I
R
I
S
V
L
I
R
E
D
D
L
D
A
A
A
R
A
L
H
E
Q
F
Q
L
---------
21
PsiBlast_CBE
93.86
46%
-109
- C2 -
3AB2
5
AK_CORGL
O:
[3-407]
-
L
V
V
Q
K
Y
G
G
S
S
L
E
S
A
E
R
I
R
N
V
A
E
R
I
V
A
T
K
K
A
G
N
D
V
V
V
V
C
S
A
M
G
D
T
T
D
E
L
L
E
L
A
----------------------------
A
A
V
N
---------------------------------------------------------
P
V
P
---------------------------------------------------------
P
-----------------------
A
R
E
M
D
M
L
L
T
A
G
E
R
I
S
N
A
L
V
A
M
A
I
E
S
L
G
A
E
A
Q
S
F
T
G
S
Q
A
G
V
L
T
-------------
T
-
P
-
G
R
V
R
E
A
L
D
E
G
K
-----
I
C
I
V
A
G
F
Q
--------------
G
R
G
G
S
D
T
T
A
V
A
L
A
A
A
L
N
A
D
V
C
E
I
Y
S
D
V
D
G
V
Y
T
A
D
P
R
I
V
P
N
A
Q
K
L
E
K
L
S
F
E
E
M
L
E
L
A
A
V
G
S
K
I
L
V
L
R
S
V
E
Y
A
R
A
F
N
V
P
L
R
V
R
S
S
Y
S
-
N
-
D
-
P
G
T
L
I
A
G
S
M---
E
D
I
P
------
V
E
E
A
V
L
T
G
V
A
T
D
K
S
E
A
K
V
T
V
--
L
G
--
I
S
--
D
K
P
G
E
A
A
K
V
F
R
A
L
A
D
A
E
I
N
I
D
M
V
L
Q
N
V
S
SV
E
--
D
G
T
T
D
I
T
F
T
C
P
R
S
D
G
---
R
R
A
M
E
I
---
L
-------
K
K
L
Q
-------
V
Q
-------
G
--
N
WT
N
V
---
L
------
Y
D
D
Q
V
G
K
V
S
L
V
G
A
G
M
K
S
H
P
G
V
T
A
E
F
M
E
A
L
R
D
V
N
V
N
I
E
L
I
S
--
T
--
S
E
I
R
I
S
V
L
I
R
E
D
D
L
D
A
A
A
R
A
L
H
E
Q
F
Q
L
G
G
-------
1
PsiBlast_PDB
93.83
46%
-119
- C2 -
3AAW
3
AK_CORGL
A:
[3-407]
-
L
V
V
Q
K
Y
G
G
S
S
L
E
S
A
E
R
I
R
N
V
A
E
R
I
V
A
T
K
K
A
G
N
D
V
V
V
V
C
S
A
M
G
D
T
T
D
E
L
L
E
L
A
----------------------------
A
A
V
N
---------------------------------------------------------
P
V
P
---------------------------------------------------------
P
-----------------------
A
R
E
M
D
M
L
L
T
A
G
E
R
I
S
N
A
L
V
A
M
A
I
E
S
L
G
A
E
A
Q
S
F
T
--------------------
V
T
-
P
-
G
R
V
R
E
A
L
D
E
G
K
-----
I
C
I
V
A
G
F
---
V
N
K
E
-
T
R
D
V
T
T
L
G
R
G
G
S
D
T
T
A
V
A
L
A
A
A
L
N
A
D
V
C
E
I
Y
S
D
V
D
G
V
Y
T
A
D
P
R
I
V
P
N
A
Q
K
L
E
K
L
S
F
E
E
M
L
E
L
A
A
V
G
S
K
I
L
V
L
R
S
V
E
Y
A
R
A
F
N
V
P
L
R
V
R
S
S
Y
S
-
N
-
D
-
P
G
T
L
I
A
G
S
M---
E
D
I
P
------
V
E
E
A
V
L
T
G
V
A
T
D
K
S
E
A
K
V
T
V
--
L
G
--
I
S
--
D
K
P
G
E
A
A
K
V
F
R
A
L
A
D
A
E
I
N
I
D
M
V
L
Q
N
V
S
SV
E
--
D
G
T
T
D
I
T
F
T
C
P
R
S
D
G
---
R
R
A
M
E
I
---
L
-------
K
K
L
Q
-------
V
Q
-------
G
--
N
WT
N
V
---
L
------
Y
D
D
Q
V
G
K
V
S
L
V
G
A
G
M
K
S
H
P
G
V
T
A
E
F
M
E
A
L
R
D
V
N
V
N
I
E
L
I
S
--
T
--
S
E
I
R
I
S
V
L
I
R
E
D
D
L
D
A
A
A
R
A
L
H
E
Q
F
Q
L
G
G
-------
2
PsiBlast_PDB
88.81
44%
-110
- C3 -
3L76
5
?
A:
[3-416]
-
L
I
V
Q
K
F
G
G
T
S
V
G
T
V
E
R
I
Q
A
V
A
Q
R
I
K
R
T
V
Q
G
G
N
S
L
V
V
V
V
S
A
M
G
K
S
T
D
V
L
V
D
L
A
----------------------------
Q
Q
I
S
---------------------------------------------------------
P
N
P
---------------------------------------------------------
C
-----------------------
R
R
E
M
D
M
L
L
S
T
G
E
Q
V
S
I
A
L
L
S
L
A
L
Q
E
I
D
Q
P
A
I
S
L
T
G
A
Q
V
G
I
V
T
E
--------
I
L
E
I
R
-
P
-
D
R
L
E
H
H
L
R
E
G
K
-----
V
V
V
V
A
G
F
Q
G
I-----
H
L
E
I
T
T
L
G
R
G
G
S
D
T
S
A
V
A
L
A
A
A
L
K
A
D
F
C
E
I
Y
T
D
V
P
G
I
L
T
T
D
P
R
L
V
P
E
A
Q
L
M
A
E
I
T
C
D
E
M
L
E
L
A
S
L
G
A
K
V
L
H
P
R
A
V
E
I
A
R
N
Y
G
I
P
L
V
V
R
S
S
W
S
-
D
-
E
-
P
G
T
K
V
V
A
P
PVQN
R
S
L
V
G
L
--
E
-
I
A
K
-
A
V
D
G
V
E
Y
D
A
D
Q
A
K
V
A
L
--
L
R
--
V
P
--
D
R
P
G
V
A
S
K
L
F
R
D
I
A
Q
Q
Q
V
D
I
D
L
I
I
Q
S
I
H
--
D
--
G
N
S
N
D
I
A
F
T
V
V
K
D
L
L
N
T
A
E
A
V
T
S
A
---
I
-------
A
P
A
L
-------
R
S
-------
Y
--
P
--
E
A
---
D
QEA
E
I
I
V
E
K
G
I
A
K
I
A
I
A
G
A
G
M
I
G
R
P
G
I
A
A
K
M
F
K
T
L
A
D
V
G
V
N
I
E
M
I
S
--
T
--
S
E
V
K
V
S
C
V
I
D
Q
R
D
A
D
R
A
I
A
A
L
S
N
A
F
G
V
T
L
-------
89
HHSearch
88.38
45%
-104
- C3 -
3L76
5
?
A:
[2-417]
A
L
I
V
Q
K
F
G
G
T
S
V
G
T
V
E
R
I
Q
A
V
A
Q
R
I
K
R
T
V
Q
G
G
N
S
L
V
V
V
V
S
A
M
G
K
S
T
D
V
L
V
D
L
A
----------------------------
Q
Q
I
S
---------------------------------------------------------
P
N
P
---------------------------------------------------------
C
-----------------------
R
R
E
M
D
M
L
L
S
T
G
E
Q
V
S
I
A
L
L
S
L
A
L
Q
E
I
D
Q
P
A
I
S
L
T
G
A
Q
V
G
I
V
T
E
--------
I
L
E
I
R
-
P
-
D
R
L
E
H
H
L
R
E
G
K
-----
V
V
V
V
A
G
F
Q
G
-
I
--
H
-
L
-
E
I
T
T
L
G
R
G
G
S
D
T
S
A
V
A
L
A
A
A
L
K
A
D
F
C
E
I
Y
T
D
V
P
G
I
L
T
T
D
P
R
L
V
P
E
A
Q
L
M
A
E
I
T
C
D
E
M
L
E
L
A
S
L
G
A
K
V
L
H
P
R
A
V
E
I
A
R
N
Y
G
I
P
L
V
V
R
S
S
W
S
-
D
-
E
-
P
G
T
K
V
V
A
P
----
P
V
Q
N
R
S
LV
G
L
E
I
A
K
A
V
D
G
V
E
Y
D
A
D
Q
A
K
V
A
L
--
L
R
--
V
P
--
D
R
P
G
V
A
S
K
L
F
R
D
I
A
Q
Q
Q
V
D
I
D
L
I
I
Q
S
I
H
--
D
--
G
N
S
N
D
I
A
F
T
V
V
K
D
L
L
---
N
T
A
E
A
V
T
S
A
I
-------
A
P
A
L
RSYPEA-
D
Q
-------
E
--
A
--
E
I
---
I
------
V
E
K
G
I
A
K
I
A
I
A
G
A
G
M
I
G
R
P
G
I
A
A
K
M
F
K
T
L
A
D
V
G
V
N
I
E
M
I
S
--
T
--
S
E
V
K
V
S
C
V
I
D
Q
R
D
A
D
R
A
I
A
A
L
S
N
A
F
G
V
T
L
-------
85
HHSearch
88.30
39%
-99
- C2 -
3C1M
6
AK_METJA
A:
[2-470]
-
T
T
V
M
K
F
G
G
T
S
V
G
S
G
E
R
I
R
H
V
A
K
I
V
T
K
R
K
K
E
D
D
D
V
V
V
V
V
S
A
M
S
E
V
T
N
A
L
V
E
I
S
----------------------------
Q
Q
A
L
DVRD
I
A
K
V
G
D
F
I
K
F
I
R
E
K
H
Y
K
A
I
E
E
A
I
KS
E
E
I
K
E
E
V
K
K
I
I
D
S
R
I
E
E
L
E
K
V
L
I
G
V
A
Y
L
G
E
L
---------------------------------------------------------
T
-----------------------
P
K
S
R
D
Y
I
L
S
F
G
E
R
L
S
S
P
I
L
S
G
A
I
R
D
L
G
E
K
S
I
A
L
E
G
G
E
A
G
I
I
T
D
N
N
F
G
S
A
-
R
V
K
R
L
E
V
K
-
E
R
L
L
P
L
L
K
E
G
I
-----
I
P
V
V
T
G
F
I
G
-
T
T
E
E
-
G
-
Y
I
T
T
L
G
R
G
G
S
D
Y
S
A
A
L
I
G
Y
G
L
D
A
D
I
I
E
I
W
T
D
V
S
G
V
Y
T
T
D
P
R
L
V
P
T
A
R
R
I
P
K
L
S
Y
I
E
A
M
E
L
A
Y
F
G
A
K
V
L
H
P
R
T
I
E
P
A
M
E
K
G
I
P
I
L
V
K
N
T
F
E
-
P
E
S
-
E
G
T
L
I
T
N
D
----
M
E
M
--------
S
D
S
I
V
K
A
I
S
T
I
K
N
V
A
L
I
N
I
--
F
G
AG
M
V
--
G
V
S
G
T
A
A
R
I
F
K
A
L
G
E
E
E
V
N
V
I
L
I
S
Q
G
S
S
--
E
-----
T
N
I
S
L
V
V
S
E
E
D
V
---
D
K
A
L
K
A
---
L
-------
K
R
E
F
-------
G
D
SFLNNNL
I
--
R
--
D
V
---
S
------
V
D
K
D
V
C
V
I
S
V
V
G
A
G
M
R
G
A
K
G
I
A
G
K
I
F
T
A
V
S
E
S
G
A
N
I
K
M
I
A
Q
G
S
--
S
E
V
N
I
S
F
V
I
D
E
K
D
L
L
N
C
V
R
K
L
H
E
K
F
I
E
K
--------
106
Fugue
86.70
39%
-96
- C2 -
3C1M
6
AK_METJA
A:
[2-470]
-
T
T
V
M
K
F
G
G
T
S
V
G
S
G
E
R
I
R
H
V
A
K
I
V
T
K
R
K
K
E
D
D
D
V
V
V
V
V
S
A
M
S
E
V
T
N
A
L
V
E
I
S
----------------------------
Q
Q
A
L
---------------------------------------------------------
D
V
R
D
I
A
K
V
G
D
F
I
K
F
I
R
E
K
H
Y
K
A
I
E
E
A
I
KS
E
E
I
K
E
E
V
K
K
I
I
D
S
R
I
E
E
L
E
K
V
L
I
G
V
A
Y
L
GEL
T
-----------------------
P
K
S
R
D
Y
I
L
S
F
G
E
R
L
S
S
P
I
L
S
G
A
I
R
D
L
G
E
K
S
I
A
L
E
G
G
E
A
G
I
I
T
D
N
N
F
G
S
A
R
V
K
R
L
E
V
-
K
-
E
R
L
L
P
L
L
K
E
G
I
-----
I
P
V
V
T
G
F
I
G
-
T
T
E
E
-
G
-
Y
I
T
T
L
G
R
G
G
S
D
Y
S
A
A
L
I
G
Y
G
L
D
A
D
I
I
E
I
W
T
D
V
S
G
V
Y
T
T
D
P
R
L
V
P
T
A
R
R
I
P
K
L
S
Y
I
E
A
M
E
L
A
Y
F
G
A
K
V
L
H
P
R
T
I
E
P
A
M
E
K
G
I
P
I
L
V
K
N
T
F
E
-
P
-
E
S
E
G
T
L
I
T
N
D
----
M
E
--------
M
S
D
S
I
V
K
A
I
S
T
I
K
N
V
A
L
I
N
I
--
F
G
AG
M
V
--
G
V
S
G
T
A
A
R
I
F
K
A
L
G
E
E
E
V
N
V
I
L
I
S
Q
G
-------
S
S
E
T
N
I
S
L
V
V
S
E
E
D
V
---
D
K
A
L
K
A
---
L
-------
K
R
E
F
GDSFLNN
N
L
-------
I
--
R
--
D
V
---
S
------
V
D
K
D
V
C
V
I
S
V
V
G
A
G
M
R
G
A
K
G
I
A
G
K
I
F
T
A
V
S
E
S
G
A
N
I
K
M
I
A
--
Q
GS
S
E
V
N
I
S
F
V
I
D
E
K
D
L
L
N
C
V
R
K
L
H
E
K
F
I
E
K
--------
39
PsiBlast_CBE
74.85
33%
-86
- C2 -
3C1M
2
AK_METJA
B:
[74-467]
---------------
E
K
H
Y
K
A
I
E
E
A
I
K
S
E
E
I
K
E
E
V
K
K
I
I
D
S
R
I
E
E
L
E
K
V
L
-
I
G
----------------------------
V
A
Y
L
---------------------------------------------------------
G
E
L
---------------------------------------------------------
T
-----------------------
P
K
S
R
D
Y
I
L
S
F
G
E
R
L
S
S
P
I
L
S
G
A
I
R
D
L
G
E
K
S
I
A
L
E
G
G
E
A
G
I
I
T
D
N
N
F
G
S
A
-
R
V
K
R
L
E
-
V
K
E
R
L
L
P
L
L
K
E
G
I
-----
I
P
V
V
T
G
F
I
G
-
T
T
E
E
-
G
-
Y
I
T
T
L
G
R
G
G
S
D
Y
S
A
A
L
I
G
Y
G
L
D
A
D
I
I
E
I
W
T
D
V
S
G
V
Y
T
T
D
P
R
L
V
P
T
A
R
R
I
P
K
L
S
Y
I
E
A
M
E
L
A
Y
F
G
A
K
V
L
H
P
R
T
I
E
P
A
M
E
K
G
I
P
I
L
V
K
N
T
F
E
P
E
-
S
-
E
G
T
L
I
T
N
D
----
M
E
--------
M
S
D
S
I
V
K
A
I
S
T
I
K
N
V
A
L
I
N
I
FG
A
G
--
M
V
--
G
V
S
G
T
A
A
R
I
F
K
A
L
G
E
E
E
V
N
V
I
L
I
S
Q
G
-------
S
S
E
T
N
I
S
L
V
V
S
E
E
D
V
---
D
K
A
L
K
A
---
L
KREFGD--
S
F
L
-------
N
N
NL-----
I
--
R
--
D
V
---
S
------
V
D
K
D
V
C
V
I
S
V
V
G
A
G
M
R
G
A
K
G
I
A
G
K
I
F
T
A
V
S
E
S
G
A
N
I
K
M
I
A
QG
S
--
S
E
V
N
I
S
F
V
I
D
E
K
D
L
L
N
C
V
R
K
L
H
E
K
F
I
E
K
--------
31
PsiBlast_CBE
74.67
33%
-86
- C2 -
2HMF
2
AK_METJA
D:
[73-466]
---------------
E
K
H
Y
K
A
I
E
E
A
I
K
S
E
E
I
K
E
E
V
K
K
I
I
D
S
R
I
E
E
L
E
K
V
L
-
I
G
----------------------------
V
A
Y
L
---------------------------------------------------------
G
E
L
---------------------------------------------------------
T
-----------------------
P
K
S
R
D
Y
I
L
S
F
G
E
R
L
S
S
P
I
L
S
G
A
I
R
D
L
G
E
K
S
I
A
L
E
G
G
E
A
G
I
I
T
D
N
N
F
G
S
A
-
R
V
K
R
L
E
-
V
K
E
R
L
L
P
L
L
K
E
G
I
-----
I
P
V
V
T
G
F
I
G
-
T
T
E
E
-
G
-
Y
I
T
T
L
G
R
G
G
S
D
Y
S
A
A
L
I
G
Y
G
L
D
A
D
I
I
E
I
W
T
D
V
S
G
V
Y
T
T
D
P
R
L
V
P
T
A
R
R
I
P
K
L
S
Y
I
E
A
M
E
L
A
Y
F
G
A
K
V
L
H
P
R
T
I
E
P
A
M
E
K
G
I
P
I
L
V
K
N
T
F
E
P
E
-
S
-
E
G
T
L
I
T
N
D
----
M
E
--------
M
S
D
S
I
V
K
A
I
S
T
I
K
N
V
A
L
I
N
I
FG
A
G
--
M
V
--
G
V
S
G
T
A
A
R
I
F
K
A
L
G
E
E
E
V
N
V
I
L
I
S
Q
G
-------
S
S
E
T
N
I
S
L
V
V
S
E
E
D
V
---
D
K
A
L
K
A
---
L
KREFGDF---
L
-------
N
N
NL-----
I
--
R
--
D
V
---
S
------
V
D
K
D
V
C
V
I
S
V
V
G
A
G
M
R
G
A
K
G
I
A
G
K
I
F
T
A
V
S
E
S
G
A
N
I
K
M
I
A
QG
S
--
S
E
V
N
I
S
F
V
I
D
E
K
D
L
L
N
C
V
R
K
L
H
E
K
F
I
E
K
--------
3
PsiBlast_PDB
74.61
33%
-87
- C2 -
2HMF
3
AK_METJA
A:
[73-466]
---------------
E
K
H
Y
K
A
I
E
E
A
I
K
S
E
E
I
K
E
E
V
K
K
I
I
D
S
R
I
E
E
L
E
K
V
L
-
I
G
----------------------------
V
A
Y
L
---------------------------------------------------------
G
E
L
---------------------------------------------------------
T
-----------------------
P
K
S
R
D
Y
I
L
S
F
G
E
R
L
S
S
P
I
L
S
G
A
I
R
D
L
G
E
K
S
I
A
L
E
G
G
E
A
G
I
I
T
D
N
N
F
G
S
A
-
R
V
K
R
L
E
-
V
K
E
R
L
L
P
L
L
K
E
G
I
-----
I
P
V
V
T
G
F
I
G
-
T
T
E
E
-
G
-
Y
I
T
T
L
G
R
G
G
S
D
Y
S
A
A
L
I
G
Y
G
L
D
A
D
I
I
E
I
W
T
D
V
S
G
V
Y
T
T
D
P
R
L
V
P
T
A
R
R
I
P
K
L
S
Y
I
E
A
M
E
L
A
Y
F
G
A
K
V
L
H
P
R
T
I
E
P
A
M
E
K
G
I
P
I
L
V
K
N
T
F
E
P
E
-
S
-
E
G
T
L
I
T
N
D
----
M
E
--------
M
S
D
S
I
V
K
A
I
S
T
I
K
N
V
A
L
I
N
I
F
G
A
G
--
M
V
--
G
V
S
G
T
A
A
R
I
F
K
A
L
G
E
E
E
V
N
V
I
L
I
S
Q
G
-------
S
S
E
T
N
I
S
L
V
V
S
E
E
D
V
---
D
K
A
L
K
A
---
L
K
R
E
FGDF---
L
-------
N
N
NL-----
I
--
R
--
D
V
---
S
------
V
D
K
D
V
C
V
I
S
V
V
G
A
G
M
R
G
A
K
G
I
A
G
K
I
F
T
A
V
S
E
S
G
A
N
I
K
M
I
A
Q
G
S
--
S
E
V
N
I
S
F
V
I
D
E
K
D
L
L
N
C
V
R
K
L
H
E
K
F
I
E
K
--------
6
PsiBlast_PDB
74.35
33%
-87
- C2 -
3C1M
5
AK_METJA
A:
[74-467]
---------------
E
K
H
Y
K
A
I
E
E
A
I
K
S
E
E
I
K
E
E
V
K
K
I
I
D
S
R
I
E
E
L
E
K
V
L
-
I
G
----------------------------
V
A
Y
L
---------------------------------------------------------
G
E
L
---------------------------------------------------------
T
-----------------------
P
K
S
R
D
Y
I
L
S
F
G
E
R
L
S
S
P
I
L
S
G
A
I
R
D
L
G
E
K
S
I
A
L
E
G
G
E
A
G
I
I
T
D
N
N
F
G
S
A
-
R
V
K
R
L
E
-
V
K
E
R
L
L
P
L
L
K
E
G
I
-----
I
P
V
V
T
G
F
I
G
-
T
T
E
E
-
G
-
Y
I
T
T
L
G
R
G
G
S
D
Y
S
A
A
L
I
G
Y
G
L
D
A
D
I
I
E
I
W
T
D
V
S
G
V
Y
T
T
D
P
R
L
V
P
T
A
R
R
I
P
K
L
S
Y
I
E
A
M
E
L
A
Y
F
G
A
K
V
L
H
P
R
T
I
E
P
A
M
E
K
G
I
P
I
L
V
K
N
T
F
E
P
E
-
S
-
E
G
T
L
I
T
N
D
----
M
E
--------
M
S
D
S
I
V
K
A
I
S
T
I
K
N
V
A
L
I
N
I
F
G
A
G
--
M
V
--
G
V
S
G
T
A
A
R
I
F
K
A
L
G
E
E
E
V
N
V
I
L
I
S
Q
G
-------
S
S
E
T
N
I
S
L
V
V
S
E
E
D
V
---
D
K
A
L
K
A
---
L
K
R
E
FGD--
S
F
L
-------
N
N
NL-----
I
--
R
--
D
V
---
S
------
V
D
K
D
V
C
V
I
S
V
V
G
A
G
M
R
G
A
K
G
I
A
G
K
I
F
T
A
V
S
E
S
G
A
N
I
K
M
I
A
Q
G
S
--
S
E
V
N
I
S
F
V
I
D
E
K
D
L
L
N
C
V
R
K
L
H
E
K
F
I
E
K
--------
32
PsiBlast_CBE
74.33
33%
-88
- C2 -
2HMF
3
AK_METJA
C:
[73-466]
---------------
E
K
H
Y
K
A
I
E
E
A
I
K
S
E
E
I
K
E
E
V
K
K
I
I
D
S
R
I
E
E
L
E
K
V
L
-
I
G
----------------------------
V
A
Y
L
---------------------------------------------------------
G
E
L
---------------------------------------------------------
T
-----------------------
P
K
S
R
D
Y
I
L
S
F
G
E
R
L
S
S
P
I
L
S
G
A
I
R
D
L
G
E
K
S
I
A
L
E
G
G
E
A
G
I
I
T
D
N
N
F
G
S
A
-
R
V
K
R
L
E
-
V
K
E
R
L
L
P
L
L
K
E
G
I
-----
I
P
V
V
T
G
F
I
G
-
T
T
E
E
-
G
-
Y
I
T
T
L
G
R
G
G
S
D
Y
S
A
A
L
I
G
Y
G
L
D
A
D
I
I
E
I
W
T
D
V
S
G
V
Y
T
T
D
P
R
L
V
P
T
A
R
R
I
P
K
L
S
Y
I
E
A
M
E
L
A
Y
F
G
A
K
V
L
H
P
R
T
I
E
P
A
M
E
K
G
I
P
I
L
V
K
N
T
F
E
P
E
-
S
-
E
G
T
L
I
T
N
D
----
M
E
--------
M
S
D
S
I
V
K
A
I
S
T
I
K
N
V
A
L
I
N
I
FG
A
G
--
M
V
--
G
V
S
G
T
A
A
R
I
F
K
A
L
G
E
E
E
V
N
V
I
L
I
S
Q
G
-------
S
S
E
T
N
I
S
L
V
V
S
E
E
D
V
---
D
K
A
L
K
A
---
L
KREFGDF---
L
-------
N
N
NL-----
I
--
R
--
D
V
---
S
------
V
D
K
D
V
C
V
I
S
V
V
G
A
G
M
R
G
A
K
G
I
A
G
K
I
F
T
A
V
S
E
S
G
A
N
I
K
M
I
A
QG
S
--
S
E
V
N
I
S
F
V
I
D
E
K
D
L
L
N
C
V
R
K
L
H
E
K
F
I
E
K
--------
33
PsiBlast_CBE
74.27
33%
-88
- C2 -
2HMF
3
AK_METJA
B:
[73-466]
---------------
E
K
H
Y
K
A
I
E
E
A
I
K
S
E
E
I
K
E
E
V
K
K
I
I
D
S
R
I
E
E
L
E
K
V
L
-
I
G
----------------------------
V
A
Y
L
---------------------------------------------------------
G
E
L
---------------------------------------------------------
T
-----------------------
P
K
S
R
D
Y
I
L
S
F
G
E
R
L
S
S
P
I
L
S
G
A
I
R
D
L
G
E
K
S
I
A
L
E
G
G
E
A
G
I
I
T
D
N
N
F
G
S
A
-
R
V
K
R
L
E
-
V
K
E
R
L
L
P
L
L
K
E
G
I
-----
I
P
V
V
T
G
F
I
G
-
T
T
E
E
-
G
-
Y
I
T
T
L
G
R
G
G
S
D
Y
S
A
A
L
I
G
Y
G
L
D
A
D
I
I
E
I
W
T
D
V
S
G
V
Y
T
T
D
P
R
L
V
P
T
A
R
R
I
P
K
L
S
Y
I
E
A
M
E
L
A
Y
F
G
A
K
V
L
H
P
R
T
I
E
P
A
M
E
K
G
I
P
I
L
V
K
N
T
F
E
P
E
-
S
-
E
G
T
L
I
T
N
D
----
M
E
--------
M
S
D
S
I
V
K
A
I
S
T
I
K
N
V
A
L
I
N
I
FG
A
G
--
M
V
--
G
V
S
G
T
A
A
R
I
F
K
A
L
G
E
E
E
V
N
V
I
L
I
S
Q
G
-------
S
S
E
T
N
I
S
L
V
V
S
E
E
D
V
---
D
K
A
L
K
A
---
L
KREFGDF---
L
-------
N
N
NL-----
I
--
R
--
D
V
---
S
------
V
D
K
D
V
C
V
I
S
V
V
G
A
G
M
R
G
A
K
G
I
A
G
K
I
F
T
A
V
S
E
S
G
A
N
I
K
M
I
A
QG
S
--
S
E
V
N
I
S
F
V
I
D
E
K
D
L
L
N
C
V
R
K
L
H
E
K
F
I
E
K
--------
9
PsiBlast_PDB
74.06
25%
-91
- C2 -
2CDQ
5
AK1_ARATH
A:
[30-482]
---
V
M
K
F
G
G
S
S
V
A
S
A
E
R
M
K
E
V
A
D
L
I
L
T
F
P
E
--
E
S
P
V
I
V
L
S
A
M
G
K
T
T
N
N
L
L
L
A
G
E
K
A
V
SCGVSNASEI
E
E
L
S
I
I
K
E
L
H
I
R
T
V
K
E
L
N
---------------------------------------------------------
I
D
P
---------------------------------------------------------
S
V
I
L
T
Y
L
E
E
L
E
Q
L
L
K
G
I
A
M
M
KELT
L
R
T
R
D
Y
L
V
S
F
G
E
C
L
S
T
R
I
F
A
A
Y
L
N
T
I
G
V
K
A
R
Q
Y
D
A
F
E
I
G
F
I
T
T
D
D
F
T
N
G
-
D
I
L
E
A
T
-
Y
-
P
A
V
A
K
R
L
Y
D
D
W
M
H
DP
A
V
P
I
V
T
G
F
L
G
-
K
G
W
K
T
G
-
A
V
T
T
L
G
R
G
G
S
D
L
T
A
T
T
I
G
K
A
L
G
L
K
E
I
Q
V
W
K
D
V
D
G
V
L
T
C
D
P
T
I
Y
K
R
A
T
P
V
P
Y
L
T
F
D
E
A
A
E
L
A
Y
F
G
A
Q
V
L
H
P
Q
S
M
R
P
A
R
E
G
E
I
P
V
R
V
K
N
S
Y
N
P
K
-
A
-
P
G
T
I
I
T
K
T
----
R
D
--------
M
T
K
S
I
L
T
S
I
V
L
K
R
N
V
T
M
L
D
I
--
A
S
--
T
R
ML
G
Q
V
G
F
L
A
K
V
F
S
I
F
E
E
L
G
I
S
V
D
V
V
A
T
S
---------
E
V
S
I
S
L
T
L
D
P
S
K
L
WSR
E
L
I
Q
Q
E
---
L
-------
D
H
V
V
-------
E
E
-------
L
--
E
--
K
I
A
V
V
N
------
L
L
K
G
R
A
I
I
S
L
I
G
-
N
V
Q
H
S
S
L
I
L
E
R
A
F
H
V
L
Y
T
K
G
V
N
V
Q
M
I
S
Q
G
A
--
S
K
V
N
I
S
F
I
V
N
E
A
E
A
E
G
C
V
Q
A
L
H
K
S
F
F
E
S
G
-------
37
PsiBlast_CBE
73.78
33%
-87
- C2 -
3C1M
4
AK_METJA
D:
[74-467]
---------------
E
K
H
Y
K
A
I
E
E
A
I
K
S
E
E
I
K
E
E
V
K
K
I
I
D
S
R
I
E
E
L
E
K
V
L
-
I
G
----------------------------
V
A
Y
L
---------------------------------------------------------
G
E
L
---------------------------------------------------------
T
-----------------------
P
K
S
R
D
Y
I
L
S
F
G
E
R
L
S
S
P
I
L
S
G
A
I
R
D
L
G
E
K
S
I
A
L
E
G
G
E
A
G
I
I
T
D
N
N
F
G
S
A
-
R
V
K
R
L
E
-
V
K
E
R
L
L
P
L
L
K
E
G
I
-----
I
P
V
V
T
G
F
I
G
-
T
T
E
E
-
G
-
Y
I
T
T
L
G
R
G
G
S
D
Y
S
A
A
L
I
G
Y
G
L
D
A
D
I
I
E
I
W
T
D
V
S
G
V
Y
T
T
D
P
R
L
V
P
T
A
R
R
I
P
K
L
S
Y
I
E
A
M
E
L
A
Y
F
G
A
K
V
L
H
P
R
T
I
E
P
A
M
E
K
G
I
P
I
L
V
K
N
T
F
E
P
E
-
S
-
E
G
T
L
I
T
N
D
----
M
E
--------
M
S
D
S
I
V
K
A
I
S
T
I
K
N
V
A
L
I
N
I
FG
A
G
--
M
V
--
G
V
S
G
T
A
A
R
I
F
K
A
L
G
E
E
E
V
N
V
I
L
I
S
Q
G
-------
S
S
E
T
N
I
S
L
V
V
S
E
E
D
V
---
D
K
A
L
K
A
---
L
KREFGD-
K
S
F
L
-------
N
N
NL-----
I
--
R
--
D
V
---
S
------
V
D
K
D
V
C
V
I
S
V
V
G
A
G
M
R
G
A
K
G
I
A
G
K
I
F
T
A
V
S
E
S
G
A
N
I
K
M
I
A
QG
S
--
S
E
V
N
I
S
F
V
I
D
E
K
D
L
L
N
C
V
R
K
L
H
E
K
F
I
E
K
--------
56
PsiBlast_CBE
54.06
39%
-106
- C2 -
3S1T
5
B:
[4-159]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
I
L
T
G
V
A
H
D
R
S
E
A
K
V
T
I
--
V
G
--
L
P
--
D
I
P
G
Y
A
A
K
V
F
R
A
V
A
D
A
D
V
N
I
D
M
V
L
Q
N
V
S
--
K
VE
D
G
K
T
D
I
T
F
T
C
S
R
D
V
G
---
P
A
A
V
E
K
---
L
-------
D
S
L
R
-------
N
E
-------
I
GF
S
--
Q
L
---
L
------
Y
D
D
H
I
G
K
V
S
L
I
G
A
G
M
R
S
H
P
G
V
T
A
T
F
C
E
A
L
A
A
V
G
V
N
I
E
L
I
S
--
T
--
S
E
I
R
I
S
V
L
C
R
D
T
E
L
D
K
A
V
V
A
L
H
E
A
F
G
L
---------
108
Fugue
53.09
43%
-107
* C2 *
2DTJ
2
AK_CORGL
A:
[4-167]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
V
L
T
G
V
A
T
D
K
S
E
A
K
V
T
V
--
L
G
--
I
S
--
D
K
P
G
E
A
A
K
V
F
R
A
L
A
D
A
E
I
N
I
D
M
V
L
Q
N
V
S
SV
E
--
D
G
T
T
D
I
T
F
T
C
P
R
S
D
G
---
R
R
A
M
E
I
---
L
-------
K
K
L
Q
-------
V
Q
-------
G
NW
T
--
N
V
---
L
------
Y
D
D
Q
V
G
K
V
S
L
V
G
A
G
M
K
S
H
P
G
V
T
A
E
F
M
E
A
L
R
D
V
N
V
N
I
E
L
I
S
--
T
--
S
E
I
R
I
S
V
L
I
R
E
D
D
L
D
A
A
A
R
A
L
H
E
Q
F
Q
L
G
G
EDEAVVY
48
PsiBlast_CBE
52.56
43%
-104
- C2 -
2DTJ
3
B:
[2-158]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
A
V
L
T
G
V
A
T
D
K
S
E
A
K
V
T
V
--
L
G
--
I
S
--
D
K
P
G
E
A
A
K
V
F
R
A
L
A
D
A
E
I
N
I
D
M
V
L
Q
N
V
S
SV
E
--
D
G
T
T
D
I
T
F
T
C
P
R
S
D
G
---
R
R
A
M
E
I
---
L
-------
K
K
L
Q
-------
V
Q
-------
G
--
N
WT
N
V
---
L
------
Y
D
D
Q
V
G
K
V
S
L
V
G
A
G
M
K
S
H
P
G
V
T
A
E
F
M
E
A
L
R
D
V
N
V
N
I
E
L
I
S
--
T
--
S
E
I
R
I
S
V
L
I
R
E
D
D
L
D
A
A
A
R
A
L
H
E
Q
F
Q
L
E
A
-------
46
PsiBlast_CBE
52.46
43%
-111
- C2 -
3AAW
3
?
D:
[1-158]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
E
A
V
L
T
G
V
A
T
D
K
S
E
A
K
V
T
V
--
L
G
--
I
S
--
D
K
P
G
E
A
A
K
V
F
R
A
L
A
D
A
E
I
N
I
D
M
V
L
Q
N
V
S
SV
E
--
D
G
T
T
D
I
T
F
T
C
P
R
S
D
G
---
R
R
A
M
E
I
---
L
-------
K
K
L
Q
-------
V
Q
-------
G
--
N
WT
N
V
---
L
------
Y
D
D
Q
V
G
K
V
S
L
V
G
A
G
M
K
S
H
P
G
V
T
A
E
F
M
E
A
L
R
D
V
N
V
N
I
E
L
I
S
--
T
--
S
E
I
R
I
S
V
L
I
R
E
D
D
L
D
A
A
A
R
A
L
H
E
Q
F
Q
L
G
--------
15
PsiBlast_PDB
52.26
39%
-106
- C2 -
3S1T
6
AK_MYCTU
A:
[4-159]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
I
L
T
G
V
A
H
D
R
S
E
A
K
V
T
I
--
V
G
--
L
P
--
D
I
P
G
Y
A
A
K
V
F
R
A
V
A
D
A
D
V
N
I
D
M
V
L
Q
N
V
S
--
K
VE
D
G
K
T
D
I
T
F
T
C
S
R
D
V
G
---
P
A
A
V
E
K
---
L
-------
D
S
L
R
-------
N
E
-------
I
GF
S
--
Q
L
---
L
------
Y
D
D
H
I
G
K
V
S
L
I
G
A
G
M
R
S
H
P
G
V
T
A
T
F
C
E
A
L
A
A
V
G
V
N
I
E
L
I
S
--
T
--
S
E
I
R
I
S
V
L
C
R
D
T
E
L
D
K
A
V
V
A
L
H
E
A
F
G
L
G
G
-------
47
PsiBlast_CBE
48.57
43%
-101
- C2 -
3AAW
3
?
B:
[1-158]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
E
A
V
L
T
G
V
A
T
D
K
S
E
A
K
V
T
V
--
L
G
--
I
S
--
D
K
P
G
E
A
A
K
V
F
R
A
L
A
D
A
E
I
N
I
D
M
V
L
Q
N
V
S
SV
E
--
D
G
T
T
D
I
T
F
T
C
P
R
S
D
G
---
R
R
A
M
E
I
---
L
-------
K
K
L
Q
-------
V
Q
-------
G
--
N
WT
N
V
---
L
------
Y
D
D
Q
V
G
K
V
S
L
V
G
A
G
M
K
S
H
P
G
V
T
A
E
F
M
E
A
L
R
D
V
N
V
N
I
E
L
I
S
--
T
--
S
E
I
R
I
S
V
L
I
R
E
D
D
L
D
A
A
A
R
A
L
H
E
Q
F
Q
L
G
G
-------