@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_1153: (2015-12-21 )
MIVKRLNPDALKSALQKIGPEKIAQTHMRQKGVSFVFEIQHLPLSAALILKQEAISVGGDFATPRDCILAKEPFYDGVLIASAKQLERLIVKCHSQPFGLKHLAQELKSHLKAKKPNAPQIMAILNLTPDSFYEKSRFDSKKALEEIYQWLEKGITLIDIGAASSRPQSEIIDPKVEQDRLKEILLEIKSQKLYQRAQFSIDTYHATTAQMALEHYFSILNDVSGFNSIEMLEVARDYQPTCILMHAQKTPKDMQENVFYHNLFDEMDRFFKEKLEVLEKYTLQDIILDIGFGFAKLKEHNLALIKHLSHFLKFKKPLLVGASRKNTIGLITGREVQDRLAGTLSLHLMALQNGASILRAHDIDEHIDLIKVFKSLEETD
Atome Classification :
(51 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140-........150-----.......160.......170.......180.......190.--...--...200.......210.......220......-.230...-...-.-240......-.250.-......260----------------------------.......270....--...280.--.--.--....290.......300.......310.----------------......320.......330..------.-....340.......350.......360.......370.......380
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MIVKRL
N
P
D
A
L
K
S
A
L
Q
KI
G
P
E
K
I
A
Q
T
H
M
R
QKG
V
S
F
V
F
E
I
QHLP
L
S
A
A
L
I
L
K
Q
E
A
ISVGGDFATP
R
D
C
I
LAKEPFYD
G
V
L
IA
S
A
K
Q
L
E
R
L
I
V
K
CHSQPF
G
L
K
H
L
A
Q
E
L
K
S
H
L
KAKKPNA
P
Q
I
M
A
I
L
NLTP
D
S
F
Y
E
K
SRFD
S
-
K
-
K
A
L
E
E
I
Y
Q
W
L
E-----KG
I
T
L
I
D
IGAASSRPQSEIIDPKV
E
Q
D
R
L
K
E
I
L
L
E
I
K
S
Q
K
L
--
Y
Q
R
--AQ
F
S
I
D
T
YH
A
T
T
A
Q
M
A
L
E
H
Y
F
S
I
L
N
DVSGF
N
S
-
I
E
M
L
E
V
A
-RDY-Q-P
T
C
I
L
M
HAQ-KT
P
K
D
-
M
Q
E
N
V
F
Y
H
N
----------------------------
L
F
D
E
M
D
R
F
F
K
E
K
L
E
--
V
L
E
K
Y
T
L
--
Q
--
D
--
I
I
L
D
IGF
G
F
A
K
LKEH
N
L
A
L
I
K
H
L
S
H
F
L
K
----------------FKK
P
L
L
VGASRK
N
T
I
G
L
IT
G
R
------
E
-
V
Q
D
R
L
A
G
T
L
S
L
H
L
M
A
L
QNG
A
S
I
L
R
AH
D
I
D
E
H
I
D
L
I
K
V
F
K
S
L
EETD
61
HHSearch
90.52
32%
-106
- C4 -
2DQW
-
?
A:
[26-287]
-------------------------------------------------------------------------------------------------------------------
L
D
R
V
R
L
L
G
V
L
N
L
T
P
--------------
R
A
L
E
R
A
R
E
M
V
A
-----
E
G
A
D
I
L
D
L
G
A
E
-----------
E
E
E
K
R
R
L
L
P
V
L
E
A
V
L
S
L
------
G
--
V
P
V
S
V
D
T
R
K
P
E
V
A
E
E
A
L
K
L
G
A
H
L
L
N
D
V
T
G
L
R
D
-
E
R
M
V
A
L
A
-
A
R
H
-
G
-
V
A
A
V
V
M
H
M
P
V
P
D
P
A
T
-
M
M
A
H
A
R
Y
R
D
----------------------------
V
V
A
E
V
K
A
F
L
E
A
Q
A
R
--
R
A
L
S
A
G
V
--
P
--
Q
--
V
V
L
D
P
G
F
G
F
G
K
L
L
E
H
N
L
A
L
L
R
R
L
D
E
I
V
A
----------------
L
G
H
P
V
L
V
G
L
S
R
K
R
T
I
G
E
L
S
G
V
E-----
D
-
P
A
Q
R
V
H
G
S
V
A
A
H
L
F
A
V
M
K
G
V
R
L
L
R
V
H
D
V
R
A
H
R
E
A
L
G
V
W
E
A
L
Y
G
--
21
PsiBlast_CBE
90.09
32%
-115
- C4 -
2DZB
1
?
B:
[30-286]
-----------------------------------------------------------------------------------------------------------------------
R
L
L
G
V
L
N
L
T
P
D
---------
P
-
E
-
R
A
L
E
R
A
R
E
M
V
A
-----
E
G
A
D
I
L
D
L
G
A
E
S
T
-------
P
V
E
E
E
K
R
R
L
L
P
V
L
E
A
V
L
S
L
G
V
--------
P
V
S
V
D
T
R
K
P
E
V
A
E
E
A
L
K
L
G
A
H
L
L
N
D
V
T
G
L
R
D
-
E
R
M
V
A
L
A
-
A
R
H
-
G
-
V
A
A
V
V
M
H
M
P
---------
A
H
A
R
Y
R
D
----------------------------
V
V
A
E
V
K
A
F
L
E
A
Q
A
R
--
R
A
L
S
A
G
V
--
P
--
Q
--
V
V
L
D
P
G
F
G
F
G
K
L
L
E
H
N
L
A
L
L
R
R
L
D
E
I
V
A
----------------
L
G
H
P
V
L
V
G
L
S
R
K
R
T
I
G
E
L
S
G
V
------
E
D
P
A
Q
R
V
H
G
S
V
A
A
H
L
F
A
V
M
K
G
V
R
L
L
R
V
H
D
V
R
A
H
R
E
A
L
G
V
W
E
A
L
Y
---
62
HHSearch
88.89
28%
-83
- C4 -
2BMB
1
FOL1_YEAST
A:
[222-543]
-------------------------------------------------------------------------------------------------------------------
V
S
P
T
Y
I
M
A
I
F
N
A
T
P
D
S
F
S
D
G
G
E
H
F
A
D
I
E
S
Q
L
N
D
I
I
K
L
C
K
D
A
L
YL
H
E
S
V
I
I
D
V
G
G
C
S
T
R
P
N
S
I
Q
A
S
E
E
E
E
I
R
R
S
I
P
L
I
K
A
I
R
E
S
T
E
LP
Q
D
K
--
V
I
L
S
I
D
T
Y
R
S
N
V
A
K
E
A
I
K
V
G
V
D
I
I
N
D
I
S
G
G
L
F
D
S
N
M
F
A
V
I
-
A
E
N
P
E
-
I
C
Y
I
L
S
H
T
R
-
G
D
I
S
T
-
M
N
R
L
A
H
Y
E
N
FALGDSIQ
Q
E
F
V
HNTDIQQLDD
L
K
D
K
T
V
L
I
R
N
V
G
Q
E
I
G
E
R
Y
I
--
K
A
I
D
N
G
V
--
K
RW
Q
--
I
L
I
D
P
G
L
G
F
A
K
T
W
K
Q
N
L
Q
I
I
R
H
I
P
I
L
K
N
Y
S
F
T
M
N
S
NN
S
Q
V
Y
V
N
L
R
N
M
P
V
L
L
G
P
S
R
K
K
F
I
G
H
I
T
K
D
V-----
D
-
A
K
Q
R
D
F
A
T
G
A
V
V
A
S
C
I
G
F
G
S
D
M
V
R
V
H
D
V
K
N
C
S
K
S
I
K
L
A
D
A
I
Y
K
G
L
6
PsiBlast_PDB
88.26
33%
-89
- C4 -
1AJZ
2
DHPS_ECOLI
A:
[15-271]
----------------------------------------------------------------------------------------------------------------------
P
H
V
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
T
H
N
S
-
L
I
D
A
V
K
H
A
N
L
M
I
N
-----
A
G
A
T
I
I
D
V
G
G
E
S
T
R
P
G
A
A
E
V
S
V
E
E
E
L
Q
R
V
I
P
V
V
-
E
A
I
A
Q
R
F
----
E
--
V
W
I
S
V
D
T
S
K
P
E
V
I
R
E
S
A
K
V
G
A
H
I
I
N
D
I
R
S
L
S
E
-
P
G
A
L
E
A
A
-
A
E
T
-
G
L
P
V
C
-
L
M
H
M
Q
-
G
N
P
K
T
-
M
Q
E
A
P
K
Y
D
D
----------------------------
V
F
A
E
V
N
R
Y
F
I
E
Q
I
A
--
R
C
E
Q
A
G
I
AK
E
--
K
--
L
L
L
D
P
G
F
G
F
G
K
N
L
S
H
N
Y
S
L
L
A
R
L
A
E
F
H
H
----------------
F
N
L
P
L
L
V
G
M
S
R
K
S
M
I
G
Q
L
L
N
V
------
G
-
P
S
E
R
L
S
G
S
L
A
C
A
V
I
A
A
M
Q
G
A
H
I
I
R
V
H
D
V
K
E
T
V
E
A
M
R
V
V
E
A
T
L
S
A
K
5
PsiBlast_PDB
87.01
33%
-90
- C4 -
1AJ2
2
DHPS_ECOLI
A:
[15-271]
----------------------------------------------------------------------------------------------------------------------
P
H
V
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
T
H
N
S
-
L
I
D
A
V
K
H
A
N
L
M
I
N
-----
A
G
A
T
I
I
D
V
G
G
E
S
T
R
P
G
A
A
E
V
S
V
E
E
E
L
Q
R
V
I
P
V
V
-
E
A
I
A
Q
R
F
----
E
--
V
W
I
S
V
D
T
S
K
P
E
V
I
R
E
S
A
K
V
G
A
H
I
I
N
D
I
R
S
L
S
E
-
P
G
A
L
E
A
A
-
A
E
T
-
G
L
P
V
C
-
L
M
H
M
Q
-
G
N
P
K
T
-
M
Q
E
A
P
K
Y
D
D
----------------------------
V
F
A
E
V
N
R
Y
F
I
E
Q
I
A
--
R
C
E
Q
A
G
I
AK
E
--
K
--
L
L
L
D
P
G
F
G
F
G
K
N
L
S
H
N
Y
S
L
L
A
R
L
A
E
F
H
H
----------------
F
N
L
P
L
L
V
G
M
S
R
K
S
M
I
G
Q
L
L
N
V
------
G
-
P
S
E
R
L
S
G
S
L
A
C
A
V
I
A
A
M
Q
G
A
H
I
I
R
V
H
D
V
K
E
T
V
E
A
M
R
V
V
E
A
T
L
S
A
K
39
PsiBlast_CBE
86.02
31%
-108
- C4 -
3TYE
5
?
A:
[42-291]
------------------------------------------------------------------------------------------------------------------------
I
M
G
I
L
N
V
T
P
------
G
S
Y
N
E
V
D
-
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
E
S
T
R
P
G
F
A
K
V
--
S
V
E
E
E
-
I
K
R
V
V
P
M
I
Q
A
V
S
K
--
E
V
K
--
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
-
A
H
Y
-
D
-
V
P
I
I
L
M
H
N
R
---------
D
N
M
N
Y
R
N
----------------------------
L
M
A
D
M
I
A
D
L
Y
D
S
I
K
--
I
A
K
D
A
G
V
--
R
--
D
EN
I
I
L
D
P
G
I
G
F
A
K
T
P
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
D
L
------
P
-
V
E
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
K
-
66
HHSearch
85.73
32%
-90
- C4 -
1AJ0
3
DHPS_ECOLI
A:
[13-274]
--------------------------------------------------------------------------------------------------------------------
S
H
P
H
V
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
T
H
N
S
-
L
I
D
A
V
K
H
A
N
L
M
I
N
-----
A
G
A
T
I
I
D
V
G
G
E
S
T
R
P
G
A
A
E
V
S
V
E
E
E
L
Q
R
V
I
P
V
V
E
A
I
A
Q
R
F
-----
E
--
V
W
I
S
V
D
T
S
K
P
E
V
I
R
E
S
A
K
V
G
A
H
I
I
N
D
I
R
S
L
S
E
-
P
G
A
L
E
A
A
-
A
E
T
-
G
-
L
P
V
C
L
M
H
M
Q
-
G
N
P
K
T
-
M
Q
E
A
P
K
Y
D
D
----------------------------
V
F
A
E
V
N
R
Y
F
I
E
Q
I
A
--
R
C
E
Q
A
G
I
--
A
KE
K
--
L
L
L
D
P
G
F
G
F
G
K
N
L
S
H
N
Y
S
L
L
A
R
L
A
E
F
H
H
----------------
F
N
L
P
L
L
V
G
M
S
R
K
S
M
I
G
Q
L
L
N
V
------
G
-
P
S
E
R
L
S
G
S
L
A
C
A
V
I
A
A
M
Q
G
A
H
I
I
R
V
H
D
V
K
E
T
V
E
A
M
R
V
V
E
A
T
L
S
A
K
40
PsiBlast_CBE
85.72
31%
-113
- C4 -
3TYD
7
?
B:
[42-291]
------------------------------------------------------------------------------------------------------------------------
I
M
G
I
L
N
V
T
P
D
----
G
G
S
Y
N
E
V
D
-
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
E
S
T
---------
S
V
E
E
E
-
I
K
R
V
V
P
M
I
Q
A
V
S
K
--
E
V
K
--
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
-
A
H
Y
-
D
-
V
P
I
I
L
M
H
N
R
---------
D
N
M
N
Y
R
N
----------------------------
L
M
A
D
M
I
A
D
L
Y
D
S
I
K
--
I
A
K
D
A
G
V
--
R
--
D
EN
I
I
L
D
P
G
I
G
F
A
K
T
P
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
D
L
------
P
-
V
E
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
K
-
1
PsiBlast_PDB
85.70
34%
-95
- C4 -
3TYU
1
?
A:
[18-274]
----------------------------------------------------------------------------------------------------------------------
P
Q
V
M
G
I
L
N
V
T
P
D
S
------
H
N
N
L
D
-
Q
A
L
Q
H
A
Q
R
M
L
S
-----
A
G
A
T
L
I
D
I
G
G
E
S
T
R
P
G
A
A
E
V
S
E
Q
E
E
L
D
R
V
V
P
V
V
-----
E
A
L
--
A
Q
R
FD
V
W
L
S
V
D
T
S
K
A
A
V
I
T
E
S
A
H
A
G
A
H
L
I
N
D
I
R
S
L
Q
E
-
P
G
A
L
E
A
A
A
K
T
G
-
L
-
P
V
C
-
L
M
H
M
Q
-
G
-----
M
Q
H
S
P
Y
Y
D
D
----------------------------
L
M
T
D
I
N
R
F
F
Q
H
H
I
E
R
C
V
A
A
G
I
A
K
--
N
--
K
--
L
L
L
D
P
G
F
G
F
G
K
N
L
A
H
N
Y
Q
L
L
A
H
L
S
E
L
H
H
----------------
F
E
L
P
L
L
V
G
M
S
R
K
S
M
V
G
Q
L
L
N
V
------
P
-
P
Q
Q
R
V
I
G
S
V
A
C
A
V
I
A
A
M
Q
G
A
Q
I
I
R
V
H
D
V
K
E
T
V
E
A
M
C
I
V
E
A
T
R
S
A
-
3
PsiBlast_PDB
85.57
34%
-89
- C4 -
3TZF
2
?
A:
[18-274]
----------------------------------------------------------------------------------------------------------------------
P
Q
V
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
C
H
N
N
L
D
-
Q
A
L
Q
H
A
Q
R
M
L
S
-----
A
G
A
T
L
I
D
I
G
G
E
S
T
R
P
G
A
A
E
V
S
E
Q
E
E
L
D
R
V
V
P
V
V
-----
E
A
L
--
A
Q
R
FD
V
W
L
S
V
D
T
S
K
A
A
V
I
T
E
S
A
H
A
G
A
H
L
I
N
D
I
R
S
L
Q
E
-
P
G
A
L
E
A
A
A
K
T
G
-
L
-
P
V
C
-
L
M
H
M
Q
-
G
Q
P
K
N
-
M
Q
H
S
P
Y
Y
D
D
----------------------------
L
M
T
D
I
N
R
F
F
Q
H
H
I
E
R
C
V
A
A
G
I
A
K
--
N
--
K
--
L
L
L
D
P
G
F
G
F
G
K
N
L
A
H
N
Y
Q
L
L
A
H
L
S
E
L
H
H
----------------
F
E
L
P
L
L
V
G
M
S
R
K
S
M
V
G
Q
L
L
N
V
------
P
-
P
Q
Q
R
V
I
G
S
V
A
C
A
V
I
A
A
M
Q
G
A
Q
I
I
R
V
H
D
V
K
E
T
V
E
A
M
C
I
V
E
A
T
R
S
A
-
22
PsiBlast_CBE
85.45
34%
-91
- C4 -
3TZF
3
?
B:
[18-274]
----------------------------------------------------------------------------------------------------------------------
P
Q
V
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
C
H
N
N
L
D
-
Q
A
L
Q
H
A
Q
R
M
L
S
-----
A
G
A
T
L
I
D
I
G
G
E
S
T
R
P
G
--
E
V
S
E
Q
E
E
L
D
R
V
V
P
V
V
-----
E
A
L
--
A
Q
R
FD
V
W
L
S
V
D
T
S
K
A
A
V
I
T
E
S
A
H
A
G
A
H
L
I
N
D
I
R
S
L
Q
E
-
P
G
A
L
E
A
A
A
K
T
G
-
L
-
P
V
C
-
L
M
H
M
Q
-
G
Q
P
K
N
-
M
Q
H
S
P
Y
Y
D
D
----------------------------
L
M
T
D
I
N
R
F
F
Q
H
H
I
E
R
C
V
A
A
G
I
A
K
--
N
--
K
--
L
L
L
D
P
G
F
G
F
G
K
N
L
A
H
N
Y
Q
L
L
A
H
L
S
E
L
H
H
----------------
F
E
L
P
L
L
V
G
M
S
R
K
S
M
V
G
Q
L
L
N
V
------
P
-
P
Q
Q
R
V
I
G
S
V
A
C
A
V
I
A
A
M
Q
G
A
Q
I
I
R
V
H
D
V
K
E
T
V
E
A
M
C
I
V
E
A
T
R
S
A
K
52
PsiBlast_CBE
85.37
31%
-112
- C4 -
3H2C
7
?
B:
[42-291]
------------------------------------------------------------------------------------------------------------------------
I
M
G
I
L
N
V
T
P
-------
S
Y
N
E
V
D
-
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
E
S
----------
S
V
E
E
E
-
I
K
R
V
V
P
M
I
Q
A
V
S
K
--
E
V
K
--
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
-
A
H
Y
-
D
-
V
P
I
I
L
M
H
N
R
---------
D
N
M
N
Y
R
N
----------------------------
L
M
A
D
M
I
A
D
L
Y
D
S
I
K
--
I
A
K
D
A
G
V
--
R
--
D
EN
I
I
L
D
P
G
I
G
F
A
K
T
P
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
D
L
------
P
-
V
E
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
K
-
4
PsiBlast_PDB
85.31
33%
-89
- C4 -
1AJ0
3
DHPS_ECOLI
A:
[15-271]
----------------------------------------------------------------------------------------------------------------------
P
H
V
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
T
H
N
S
-
L
I
D
A
V
K
H
A
N
L
M
I
N
-----
A
G
A
T
I
I
D
V
G
G
E
S
T
R
P
G
A
A
E
V
S
V
E
E
E
L
Q
R
V
I
P
V
V
-
E
A
I
A
Q
R
F
----
E
--
V
W
I
S
V
D
T
S
K
P
E
V
I
R
E
S
A
K
V
G
A
H
I
I
N
D
I
R
S
L
S
E
-
P
G
A
L
E
A
A
-
A
E
T
-
G
L
P
V
C
-
L
M
H
M
Q
-
G
N
P
K
T
-
M
Q
E
A
P
K
Y
D
D
----------------------------
V
F
A
E
V
N
R
Y
F
I
E
Q
I
A
--
R
C
E
Q
A
G
I
AK
E
--
K
--
L
L
L
D
P
G
F
G
F
G
K
N
L
S
H
N
Y
S
L
L
A
R
L
A
E
F
H
H
----------------
F
N
L
P
L
L
V
G
M
S
R
K
S
M
I
G
Q
L
L
N
V
------
G
-
P
S
E
R
L
S
G
S
L
A
C
A
V
I
A
A
M
Q
G
A
H
I
I
R
V
H
D
V
K
E
T
V
E
A
M
R
V
V
E
A
T
L
S
A
K
49
PsiBlast_CBE
84.75
31%
-109
- C4 -
3H2N
5
?
A:
[42-291]
------------------------------------------------------------------------------------------------------------------------
I
M
G
I
L
N
V
T
P
D
S
F
---
G
S
Y
N
E
V
D
-
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
E
S
T
R
-----
V
--
S
V
E
E
E
-
I
K
R
V
V
P
M
I
Q
A
V
S
K
--
E
V
K
--
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
-
A
H
Y
-
D
-
V
P
I
I
L
M
H
N
R
---------
D
N
M
N
Y
R
N
----------------------------
L
M
A
D
M
I
A
D
L
Y
D
S
I
K
--
I
A
K
D
A
G
V
--
R
--
D
EN
I
I
L
D
P
G
I
G
F
A
K
T
P
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
D
L
------
P
-
V
E
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
K
-
57
PsiBlast_CBE
84.64
31%
-108
* C4 *
1TWZ
5
?
B:
[42-291]
------------------------------------------------------------------------------------------------------------------------
I
M
G
I
L
N
V
T
P
D
----
G
G
S
Y
N
E
V
D
-
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
E
S
-------
V
--
S
V
E
E
E
-
I
K
R
V
V
P
M
I
Q
A
V
S
K
--
E
V
K
--
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
-
A
H
Y
-
D
-
V
P
I
I
L
M
H
N
R
---------
D
N
M
N
Y
R
N
----------------------------
L
M
A
D
M
I
A
D
L
Y
D
S
I
K
--
I
A
K
D
A
G
V
--
R
--
D
EN
I
I
L
D
P
G
I
G
F
A
K
T
P
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
D
L
------
P
-
V
E
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
K
-
45
PsiBlast_CBE
84.50
31%
-108
- C4 -
3TYA
7
?
B:
[42-291]
------------------------------------------------------------------------------------------------------------------------
I
M
G
I
L
N
V
T
P
D
----
G
G
S
Y
N
E
V
D
-
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
E
S
----------
S
V
E
E
E
-
I
K
R
V
V
P
M
I
Q
A
V
S
K
--
E
V
K
--
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
-
A
H
Y
-
D
-
V
P
I
I
L
M
H
N
R
---------
D
N
M
N
Y
R
N
----------------------------
L
M
A
D
M
I
A
D
L
Y
D
S
I
K
--
I
A
K
D
A
G
V
--
R
--
D
EN
I
I
L
D
P
G
I
G
F
A
K
T
P
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
D
L
------
P
-
V
E
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
K
-
2
PsiBlast_PDB
84.50
34%
-87
- C4 -
3TYZ
4
?
A:
[18-274]
----------------------------------------------------------------------------------------------------------------------
P
Q
V
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
C
H
N
N
L
D
-
Q
A
L
Q
H
A
Q
R
M
L
S
-----
A
G
A
T
L
I
D
I
G
G
E
S
T
R
P
G
A
A
E
V
S
E
Q
E
E
L
D
R
V
V
P
V
V
-----
E
A
L
--
A
Q
R
FD
V
W
L
S
V
D
T
S
K
A
A
V
I
T
E
S
A
H
A
G
A
H
L
I
N
D
I
R
S
L
Q
E
-
P
G
A
L
E
A
A
A
K
T
G
-
L
-
P
V
C
-
L
M
H
M
Q
-
G
Q
P
K
N
-
M
Q
H
S
P
Y
Y
D
D
----------------------------
L
M
T
D
I
N
R
F
F
Q
H
H
I
E
R
C
V
A
A
G
I
A
K
--
N
--
K
--
L
L
L
D
P
G
F
G
F
G
K
N
L
A
H
N
Y
Q
L
L
A
H
L
S
E
L
H
H
----------------
F
E
L
P
L
L
V
G
M
S
R
K
S
M
V
G
Q
L
L
N
V
------
P
-
P
Q
Q
R
V
I
G
S
V
A
C
A
V
I
A
A
M
Q
G
A
Q
I
I
R
V
H
D
V
K
E
T
V
E
A
M
C
I
V
E
A
T
R
S
A
-
53
PsiBlast_CBE
84.45
31%
-110
- C4 -
3H2A
5
?
B:
[42-291]
------------------------------------------------------------------------------------------------------------------------
I
M
G
I
L
N
V
T
P
-----
G
G
S
Y
N
E
V
D
-
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
E
S
T
------
V
--
S
V
E
E
E
-
I
K
R
V
V
P
M
I
Q
A
V
S
K
--
E
V
K
--
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
-
A
H
Y
-
D
-
V
P
I
I
L
M
H
N
R
---------
D
N
M
N
Y
R
N
----------------------------
L
M
A
D
M
I
A
D
L
Y
D
S
I
K
--
I
A
K
D
A
G
V
--
R
--
D
EN
I
I
L
D
P
G
I
G
F
A
K
T
P
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
D
L
------
P
-
V
E
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
K
-
46
PsiBlast_CBE
84.44
31%
-105
- C4 -
3TYA
5
?
A:
[42-291]
------------------------------------------------------------------------------------------------------------------------
I
M
G
I
L
N
V
T
P
-----
G
G
S
Y
N
E
V
D
-
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
E
S
T
----
A
K
V
--
S
V
E
E
E
-
I
K
R
V
V
P
M
I
Q
A
V
S
K
--
E
V
K
--
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
-
A
H
Y
-
D
-
V
P
I
I
L
M
H
N
R
---------
D
N
M
N
Y
R
N
----------------------------
L
M
A
D
M
I
A
D
L
Y
D
S
I
K
--
I
A
K
D
A
G
V
--
R
--
D
EN
I
I
L
D
P
G
I
G
F
A
K
T
P
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
D
L
------
P
-
V
E
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
K
G
43
PsiBlast_CBE
84.34
31%
-104
- C4 -
3TYB
7
?
B:
[42-291]
------------------------------------------------------------------------------------------------------------------------
I
M
G
I
L
N
V
T
P
D
----
G
G
S
Y
N
E
V
D
-
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
E
S
----------
S
V
E
E
E
-
I
K
R
V
V
P
M
I
Q
A
V
S
K
--
E
V
K
--
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
-
A
H
Y
-
D
-
V
P
I
I
L
M
H
N
R
---------
D
N
M
N
Y
R
N
----------------------------
L
M
A
D
M
I
A
D
L
Y
D
S
I
K
--
I
A
K
D
A
G
V
--
R
--
D
EN
I
I
L
D
P
G
I
G
F
A
K
T
P
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
D
L
------
P
-
V
E
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
K
-
23
PsiBlast_CBE
84.04
34%
-88
- C4 -
3TYZ
4
?
B:
[18-274]
----------------------------------------------------------------------------------------------------------------------
P
Q
V
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
C
H
N
N
L
D
-
Q
A
L
Q
H
A
Q
R
M
L
S
-----
A
G
A
T
L
I
D
I
G
G
E
S
T
R
P
G
A
A
E
V
S
E
Q
E
E
L
D
R
V
V
P
V
V
-----
E
A
L
--
A
Q
R
FD
V
W
L
S
V
D
T
S
K
A
A
V
I
T
E
S
A
H
A
G
A
H
L
I
N
D
I
R
S
L
Q
E
-
P
G
A
L
E
A
A
A
K
T
G
-
L
-
P
V
C
-
L
M
H
M
Q
-
G
Q
P
K
N
-
M
Q
H
S
P
Y
Y
D
D
----------------------------
L
M
T
D
I
N
R
F
F
Q
H
H
I
E
RC
V
A
A
G
I
A
K
--
N
--
K
--
L
L
L
D
P
G
F
G
F
G
K
N
L
A
H
N
Y
Q
L
L
A
H
L
S
E
L
H
H
----------------
F
E
L
P
L
L
V
G
M
S
R
K
S
M
V
G
Q
L
L
N
V
------
P
-
P
Q
Q
R
V
I
G
S
V
A
C
A
V
I
A
A
M
Q
G
A
Q
I
I
R
V
H
D
V
K
E
T
V
E
A
M
C
I
V
E
A
T
R
S
A
K
9
PsiBlast_PDB
83.99
31%
-106
- C4 -
1TWZ
5
?
A:
[42-291]
------------------------------------------------------------------------------------------------------------------------
I
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
S
Y
N
E
V
D
-
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
E
S
-------
V
--
S
V
E
E
E
-
I
K
R
V
V
P
M
I
Q
A
V
S
K
--
E
V
K
--
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
-
A
H
Y
-
D
-
V
P
I
I
L
M
H
N
R
---------
D
N
M
N
Y
R
N
----------------------------
L
M
A
D
M
I
A
D
L
Y
D
S
I
K
--
I
A
K
D
A
G
V
--
R
--
D
EN
I
I
L
D
P
G
I
G
F
A
K
T
P
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
D
L
------
P
-
V
E
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
K
-
41
PsiBlast_CBE
83.82
31%
-111
- C4 -
3TYD
8
?
A:
[42-291]
------------------------------------------------------------------------------------------------------------------------
I
M
G
I
L
N
V
T
P
D
S
F
S
--
G
S
Y
N
E
V
D
-
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
E
S
T
R
P
G
F
A
K
V
--
S
V
E
E
E
-
I
K
R
V
V
P
M
I
Q
A
V
S
K
--
E
V
K
--
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
-
A
H
Y
-
D
-
V
P
I
I
L
M
H
N
R
---------
D
N
M
N
Y
R
N
----------------------------
L
M
A
D
M
I
A
D
L
Y
D
S
I
K
--
I
A
K
D
A
G
V
--
R
--
D
EN
I
I
L
D
P
G
I
G
F
A
K
T
P
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
D
L
------
P
-
V
E
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
K
-
34
PsiBlast_CBE
83.74
31%
-110
- C4 -
4D9P
5
?
B:
[42-291]
------------------------------------------------------------------------------------------------------------------------
I
M
G
I
L
N
V
T
-----
D
G
G
S
Y
N
E
V
D
-
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
E
S
-------
V
--
S
V
E
E
E
-
I
K
R
V
V
P
M
I
Q
A
V
S
K
--
E
V
K
--
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
-
A
H
Y
-
D
-
V
P
I
I
L
M
H
N
R
---------
D
N
M
N
Y
R
N
----------------------------
L
M
A
D
M
I
A
D
L
Y
D
S
I
K
--
I
A
K
D
A
G
V
--
R
--
D
EN
I
I
L
D
P
G
I
G
F
A
K
T
P
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
D
L
------
P
-
V
E
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
K
-
44
PsiBlast_CBE
83.41
31%
-108
- C4 -
3TYB
5
?
A:
[42-291]
------------------------------------------------------------------------------------------------------------------------
I
M
G
I
L
N
V
T
P
---
S
D
G
G
S
Y
N
E
V
D
-
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
E
S
T
------
V
--
S
V
E
E
E
-
I
K
R
V
V
P
M
I
Q
A
V
S
K
--
E
V
K
--
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
-
A
H
Y
-
D
-
V
P
I
I
L
M
H
N
R
---------
D
N
M
N
Y
R
N
----------------------------
L
M
A
D
M
I
A
D
L
Y
D
S
I
K
--
I
A
K
D
A
G
V
--
R
--
D
EN
I
I
L
D
P
G
I
G
F
A
K
T
P
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
D
L
------
P
-
V
E
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
K
-
15
PsiBlast_PDB
83.29
31%
-103
- C4 -
3H24
6
?
A:
[42-291]
------------------------------------------------------------------------------------------------------------------------
I
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
S
Y
N
E
V
D
-
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
E
S
T
------
V
--
S
V
E
E
E
-
I
K
R
V
V
P
M
I
Q
A
V
S
K
--
E
V
K
--
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
-
A
H
Y
-
D
-
V
P
I
I
L
M
H
N
R
---------
D
N
M
N
Y
R
N
----------------------------
L
M
A
D
M
I
A
D
L
Y
D
S
I
K
--
I
A
K
D
A
G
V
--
R
--
D
EN
I
I
L
D
P
G
I
G
F
A
K
T
P
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
D
L
------
P
-
V
E
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
K
-
10
PsiBlast_PDB
83.29
31%
-108
- C4 -
1TX0
6
?
A:
[42-291]
------------------------------------------------------------------------------------------------------------------------
I
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
S
Y
N
E
V
D
-
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
--------
K
V
--
S
V
E
E
E
-
I
K
R
V
V
P
M
I
Q
A
V
S
K
--
E
V
K
--
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
-
A
H
Y
-
D
-
V
P
I
I
L
M
H
N
R
---------
D
N
M
N
Y
R
N
----------------------------
L
M
A
D
M
I
A
D
L
Y
D
S
I
K
--
I
A
K
D
A
G
V
--
R
--
D
EN
I
I
L
D
P
G
I
G
F
A
K
T
P
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
D
L
------
P
-
V
E
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
K
-
42
PsiBlast_CBE
83.12
31%
-109
- C4 -
3TYC
7
?
B:
[42-291]
------------------------------------------------------------------------------------------------------------------------
I
M
G
I
L
N
V
T
P
---
S
D
G
G
S
Y
N
E
V
D
-
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
E
S
T
------
V
--
S
V
E
E
E
-
I
K
R
V
V
P
M
I
Q
A
V
S
K
--
E
V
K
--
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
-
A
H
Y
-
D
-
V
P
I
I
L
M
H
N
R
---------
D
N
M
N
Y
R
N
----------------------------
L
M
A
D
M
I
A
D
L
Y
D
S
I
K
--
I
A
K
D
A
G
V
--
R
--
D
EN
I
I
L
D
P
G
I
G
F
A
K
T
P
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
D
L
------
P
-
V
E
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
K
G
54
PsiBlast_CBE
83.03
31%
-110
- C4 -
3H24
7
?
B:
[42-291]
------------------------------------------------------------------------------------------------------------------------
I
M
G
I
L
N
V
------
D
G
G
S
Y
N
E
V
D
-
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
E
S
-------
V
--
S
V
E
E
E
-
I
K
R
V
V
P
M
I
Q
A
V
S
K
--
E
V
K
--
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
-
A
H
Y
-
D
-
V
P
I
I
L
M
H
N
R
---------
D
N
M
N
Y
R
N
----------------------------
L
M
A
D
M
I
A
D
L
Y
D
S
I
K
--
I
A
K
D
A
G
V
--
R
--
D
EN
I
I
L
D
P
G
I
G
F
A
K
T
P
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
D
L
------
P
-
V
E
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
K
-
48
PsiBlast_CBE
82.54
31%
-105
- C4 -
3H2N
5
?
B:
[42-291]
------------------------------------------------------------------------------------------------------------------------
I
M
G
I
L
N
V
T
P
---
S
D
G
G
S
Y
N
E
V
D
-
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
E
S
T
------
V
--
S
V
E
E
E
-
I
K
R
V
V
P
M
I
Q
A
V
S
K
--
E
V
K
--
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
-
A
H
Y
-
D
-
V
P
I
I
L
M
H
N
R
---------
D
N
M
N
Y
R
N
----------------------------
L
M
A
D
M
I
A
D
L
Y
D
S
I
K
--
I
A
K
D
A
G
V
--
R
--
D
EN
I
I
L
D
P
G
I
G
F
A
K
T
P
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
D
L
------
P
-
V
E
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
K
-
64
HHSearch
82.45
30%
-103
- C4 -
1EYE
2
DHPS1_MYCTU
A:
[5-274]
---------------------------------------------------------------------------------------------------------------------
P
V
Q
V
M
G
V
L
N
V
T
D
D
S
F
S
D
G
G
C
Y
L
D
-
L
D
D
A
V
K
H
G
L
A
M
A
A
-----
A
G
A
G
I
V
D
V
G
G
--------------
E
T
S
R
V
I
P
V
V
K
E
L
A
A
Q
------
G
--
I
T
V
S
I
D
T
M
R
A
D
V
A
R
A
A
L
Q
N
G
A
Q
M
V
N
D
V
S
G
G
R
A
D
P
A
M
G
P
L
L
-
A
E
A
-
D
-
V
P
W
V
L
M
H
W
R
-
A
V
S
A
D
T
P
H
V
P
V
R
Y
G
N
----------------------------
V
V
A
E
V
R
A
D
L
L
A
S
V
A
--
D
A
V
A
A
G
V
--
D
PA
R
--
L
V
L
D
P
G
L
G
F
A
K
T
A
Q
H
N
W
A
I
L
H
A
L
P
E
L
V
A
----------------
T
G
I
P
V
L
V
G
A
S
R
K
R
F
L
G
A
L
L
A
G
PDGVMR
P
-
T
D
G
R
D
T
A
T
A
V
I
S
A
L
A
A
L
H
G
A
W
G
V
R
V
H
D
V
R
A
S
V
D
A
I
K
V
V
E
A
W
M
G
A
E
11
PsiBlast_PDB
82.11
31%
-103
- C4 -
1TX2
6
?
A:
[42-291]
------------------------------------------------------------------------------------------------------------------------
I
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
S
Y
N
E
V
D
-
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
E
S
----
F
A
K
V
--
S
V
E
E
E
-
I
K
R
V
V
P
M
I
Q
A
V
S
K
--
E
V
K
--
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
-
A
H
Y
-
D
-
V
P
I
I
L
M
H
N
R
---------
D
N
M
N
Y
R
N
----------------------------
L
M
A
D
M
I
A
D
L
Y
D
S
I
K
--
I
A
K
D
A
G
V
--
R
--
D
EN
I
I
L
D
P
G
I
G
F
A
K
T
P
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
D
L
------
P
-
V
E
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
K
-
36
PsiBlast_CBE
81.92
31%
-109
- C4 -
4D8Z
6
?
B:
[42-291]
------------------------------------------------------------------------------------------------------------------------
I
M
G
I
L
N
------
S
D
G
G
S
Y
N
E
V
D
-
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
E
-----------
S
V
E
E
E
-
I
K
R
V
V
P
M
I
Q
A
V
S
K
--
E
V
K
--
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
-
A
H
Y
-
D
-
V
P
I
I
L
M
H
N
R
---------
D
N
M
N
Y
R
N
----------------------------
L
M
A
D
M
I
A
D
L
Y
D
S
I
K
--
I
A
K
D
A
G
V
--
R
--
D
EN
I
I
L
D
P
G
I
G
F
A
K
T
P
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
D
L
------
P
-
V
E
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
K
-
20
PsiBlast_PDB
81.90
31%
-102
- C4 -
3H2M
5
?
A:
[42-291]
------------------------------------------------------------------------------------------------------------------------
I
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
S
Y
N
E
V
D
-
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
E
S
----
F
A
K
V
--
S
V
E
E
E
-
I
K
R
V
V
P
M
I
Q
A
V
S
K
--
E
V
K
--
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
-
A
H
Y
-
D
-
V
P
I
I
L
M
H
N
R
---------
D
N
M
N
Y
R
N
----------------------------
L
M
A
D
M
I
A
D
L
Y
D
S
I
K
--
I
A
K
D
A
G
V
--
R
--
D
EN
I
I
L
D
P
G
I
G
F
A
K
T
P
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
D
L
------
P
-
V
E
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
K
-
8
PsiBlast_PDB
81.75
31%
-106
- C4 -
1TWW
5
?
A:
[42-291]
------------------------------------------------------------------------------------------------------------------------
I
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
S
Y
N
E
V
D
-
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
E
S
-------
V
--
S
V
E
E
E
-
I
K
R
V
V
P
M
I
Q
A
V
S
K
--
E
V
K
--
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
-
A
H
Y
-
D
-
V
P
I
I
L
M
H
N
R
---------
D
N
M
N
Y
R
N
----------------------------
L
M
A
D
M
I
A
D
L
Y
D
S
I
K
--
I
A
K
D
A
G
V
--
R
--
D
EN
I
I
L
D
P
G
I
G
F
A
K
T
P
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
D
L
------
P
-
V
E
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
K
-
56
PsiBlast_CBE
81.72
31%
-110
- C4 -
1TX0
6
?
B:
[42-291]
------------------------------------------------------------------------------------------------------------------------
I
M
G
I
L
N
V
T
P
---
S
D
G
G
S
Y
N
E
V
D
-
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
---------
V
--
S
V
E
E
E
-
I
K
R
V
V
P
M
I
Q
A
V
S
K
--
E
V
K
--
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
-
A
H
Y
-
D
-
V
P
I
I
L
M
H
N
R
---------
D
N
M
N
Y
R
N
----------------------------
L
M
A
D
M
I
A
D
L
Y
D
S
I
K
--
I
A
K
D
A
G
V
--
R
--
D
EN
I
I
L
D
P
G
I
G
F
A
K
T
P
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
D
L
------
P
-
V
E
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
K
-
13
PsiBlast_PDB
81.47
31%
-108
- C4 -
3H22
5
?
A:
[42-291]
------------------------------------------------------------------------------------------------------------------------
I
M
G
I
L
N
V
T
P
D
S
F
--
G
G
S
Y
N
E
V
D
-
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
------------
S
V
E
E
E
-
I
K
R
V
V
P
M
I
Q
A
V
S
K
--
E
V
K
--
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
-
A
H
Y
-
D
-
V
P
I
I
L
M
H
N
R
---------
D
N
M
N
Y
R
N
----------------------------
L
M
A
D
M
I
A
D
L
Y
D
S
I
K
--
I
A
K
D
A
G
V
--
R
--
D
EN
I
I
L
D
P
G
I
G
F
A
K
T
P
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
D
L
------
P
-
V
E
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
K
-
31
PsiBlast_CBE
81.44
31%
-107
- C4 -
4DB7
5
?
A:
[42-291]
------------------------------------------------------------------------------------------------------------------------
I
M
G
I
L
N
---
D
S
F
S
D
G
G
S
Y
N
E
V
D
-
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
-------------
S
V
E
E
E
-
I
K
R
V
V
P
M
I
Q
A
V
S
K
--
E
V
K
--
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
-
A
H
Y
-
D
-
V
P
I
I
L
M
H
N
R
---------
D
N
M
N
Y
R
N
----------------------------
L
M
A
D
M
I
A
D
L
Y
D
S
I
K
--
I
A
K
D
A
G
V
--
R
--
D
EN
I
I
L
D
P
G
I
G
F
A
K
T
P
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
D
L
------
P
-
V
E
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
K
-
19
PsiBlast_PDB
81.15
31%
-101
- C4 -
3H2F
4
?
A:
[42-291]
------------------------------------------------------------------------------------------------------------------------
I
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
S
Y
N
E
V
D
-
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
E
-----
F
A
K
V
--
S
V
E
E
E
-
I
K
R
V
V
P
M
I
Q
A
V
S
K
--
E
V
K
--
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
-
A
H
Y
-
D
-
V
P
I
I
L
M
H
N
R
---------
D
N
M
N
Y
R
N
----------------------------
L
M
A
D
M
I
A
D
L
Y
D
S
I
K
--
I
A
K
D
A
G
V
--
R
--
D
EN
I
I
L
D
P
G
I
G
F
A
K
T
P
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
D
L
------
P
-
V
E
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
K
-
12
PsiBlast_PDB
80.81
31%
-106
- C4 -
3H21
4
?
A:
[42-291]
------------------------------------------------------------------------------------------------------------------------
I
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
S
Y
N
E
V
D
-
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
------------
S
V
E
E
E
-
I
K
R
V
V
P
M
I
Q
A
V
S
K
--
E
V
K
--
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
-
A
H
Y
-
D
-
V
P
I
I
L
M
H
N
R
---------
D
N
M
N
Y
R
N
----------------------------
L
M
A
D
M
I
A
D
L
Y
D
S
I
K
--
I
A
K
D
A
G
V
--
R
--
D
EN
I
I
L
D
P
G
I
G
F
A
K
T
P
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
D
L
------
P
-
V
E
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
K
-
14
PsiBlast_PDB
80.79
31%
-100
- C4 -
3H23
5
?
A:
[42-291]
------------------------------------------------------------------------------------------------------------------------
I
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
S
Y
N
E
V
D
-
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
E
S
T
R
P
G
F
A
K
V
--
S
V
E
E
E
-
I
K
R
V
V
P
M
I
Q
A
V
S
K
--
E
V
K
--
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
-
A
H
Y
-
D
-
V
P
I
I
L
M
H
N
R
---------
D
N
M
N
Y
R
N
----------------------------
L
M
A
D
M
I
A
D
L
Y
D
S
I
K
--
I
A
K
D
A
G
V
--
R
--
D
EN
I
I
L
D
P
G
I
G
F
A
K
T
P
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
D
L
------
P
-
V
E
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
K
G
16
PsiBlast_PDB
80.68
31%
-106
- C4 -
3H26
4
?
A:
[42-291]
------------------------------------------------------------------------------------------------------------------------
I
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
S
Y
N
E
V
D
-
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
------------
S
V
E
E
E
-
I
K
R
V
V
P
M
I
Q
A
V
S
K
--
E
V
K
--
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
-
A
H
Y
-
D
-
V
P
I
I
L
M
H
N
R
---------
D
N
M
N
Y
R
N
----------------------------
L
M
A
D
M
I
A
D
L
Y
D
S
I
K
--
I
A
K
D
A
G
V
--
R
--
D
EN
I
I
L
D
P
G
I
G
F
A
K
T
P
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
D
L
------
P
-
V
E
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
K
-
55
PsiBlast_CBE
80.56
31%
-110
- C4 -
1TX2
6
?
B:
[42-291]
------------------------------------------------------------------------------------------------------------------------
I
M
G
I
L
N
V
T
P
---
S
D
G
G
S
Y
N
E
V
D
-
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
---------
V
--
S
V
E
E
E
-
I
K
R
V
V
P
M
I
Q
A
V
S
K
--
E
V
K
--
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
-
A
H
Y
-
D
-
V
P
I
I
L
M
H
N
R
---------
D
N
M
N
Y
R
N
----------------------------
L
M
A
D
M
I
A
D
L
Y
D
S
I
K
--
I
A
K
D
A
G
V
--
R
--
D
EN
I
I
L
D
P
G
I
G
F
A
K
T
P
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
D
L
------
P
-
V
E
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
K
-
38
PsiBlast_CBE
80.51
31%
-108
- C4 -
4D8A
5
?
A:
[42-291]
------------------------------------------------------------------------------------------------------------------------
I
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
S
Y
N
E
V
D
-
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
---------
K
V
--
S
V
E
E
E
-
I
K
R
V
V
P
M
I
Q
A
V
S
K
--
E
V
K
--
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
-
A
H
Y
-
D
-
V
P
I
I
L
M
H
N
R
---------
D
N
M
N
Y
R
N
----------------------------
L
M
A
D
M
I
A
D
L
Y
D
S
I
K
--
I
A
K
D
A
G
V
--
R
--
D
EN
I
I
L
D
P
G
I
G
F
A
K
T
P
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
D
L
------
P
-
V
E
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
--
32
PsiBlast_CBE
80.23
31%
-109
- C4 -
4DAI
6
?
B:
[42-291]
------------------------------------------------------------------------------------------------------------------------
I
M
G
I
L
N
------
S
D
G
G
S
Y
N
E
V
D
-
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
-------------
S
V
E
E
E
-
I
K
R
V
V
P
M
I
Q
A
V
S
K
--
E
V
K
--
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
-
A
H
Y
-
D
-
V
P
I
I
L
M
H
N
R
---------
D
N
M
N
Y
R
N
----------------------------
L
M
A
D
M
I
A
D
L
Y
D
S
I
K
--
I
A
K
D
A
G
V
--
R
--
D
EN
I
I
L
D
P
G
I
G
F
A
K
T
P
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
D
L
------
P
-
V
E
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
K
-
33
PsiBlast_CBE
80.16
31%
-102
- C4 -
4DAI
5
?
A:
[42-291]
------------------------------------------------------------------------------------------------------------------------
I
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
S
Y
N
E
V
D
-
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
-------------
S
V
E
E
E
-
I
K
R
V
V
P
M
I
Q
A
V
S
K
--
E
V
K
--
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
-
A
H
Y
-
D
-
V
P
I
I
L
M
H
N
R
---------
D
N
M
N
Y
R
N
----------------------------
L
M
A
D
M
I
A
D
L
Y
D
S
I
K
--
I
A
K
D
A
G
V
--
R
--
D
EN
I
I
L
D
P
G
I
G
F
A
K
T
P
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
D
L
------
P
-
V
E
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
K
-
17
PsiBlast_PDB
80.04
31%
-112
- C4 -
3H2A
4
?
A:
[42-291]
------------------------------------------------------------------------------------------------------------------------
I
M
G
I
L
N
V
T
P
D
S
F
S
--
G
S
Y
N
E
V
D
-
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
------------
S
V
E
E
E
-
I
K
R
V
V
P
M
I
Q
A
V
S
K
--
E
V
K
--
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
-
A
H
Y
-
D
-
V
P
I
I
L
M
H
N
R
---------
D
N
M
N
Y
R
N
----------------------------
L
M
A
D
M
I
A
D
L
Y
D
S
I
K
--
I
A
K
D
A
G
V
--
R
--
D
EN
I
I
L
D
P
G
I
G
F
A
K
T
P
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
D
L
------
P
-
V
E
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
K
-
50
PsiBlast_CBE
79.83
31%
-107
- C4 -
3H2M
7
?
B:
[42-291]
------------------------------------------------------------------------------------------------------------------------
I
M
G
I
L
N
V
T
P
-----
G
G
S
Y
N
E
V
D
-
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
---------
V
--
S
V
E
E
E
-
I
K
R
V
V
P
M
I
Q
A
V
S
K
--
E
V
K
--
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
-
A
H
Y
-
D
-
V
P
I
I
L
M
H
N
R
---------
D
N
M
N
Y
R
N
----------------------------
L
M
A
D
M
I
A
D
L
Y
D
S
I
K
--
I
A
K
D
A
G
V
--
R
--
D
EN
I
I
L
D
P
G
I
G
F
A
K
T
P
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
D
L
------
P
-
V
E
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
K
-
37
PsiBlast_CBE
79.15
31%
-109
- C4 -
4D8Z
5
?
A:
[42-291]
------------------------------------------------------------------------------------------------------------------------
I
M
G
I
L
N
-
T
P
D
S
F
S
D
G
G
S
Y
N
E
V
D
-
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
---------
K
V
--
S
V
E
E
E
-
I
K
R
V
V
P
M
I
Q
A
V
S
K
--
E
V
K
--
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
-
A
H
Y
-
D
-
V
P
I
I
L
M
H
N
R
---------
D
N
M
N
Y
R
N
----------------------------
L
M
A
D
M
I
A
D
L
Y
D
S
I
K
--
I
A
K
D
A
G
V
--
R
--
D
EN
I
I
L
D
P
G
I
G
F
A
K
T
P
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
D
L
------
P
-
V
E
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
K
-
35
PsiBlast_CBE
79.04
31%
-105
- C4 -
4D9P
5
?
A:
[42-291]
------------------------------------------------------------------------------------------------------------------------
I
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
S
Y
N
E
V
D
-
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
---------
V
--
S
V
E
E
E
-
I
K
R
V
V
P
M
I
Q
A
V
S
K
--
E
V
K
--
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
-
A
H
Y
-
D
-
V
P
I
I
L
M
H
N
R
---------
D
N
M
N
Y
R
N
----------------------------
L
M
A
D
M
I
A
D
L
Y
D
S
I
K
--
I
A
K
D
A
G
V
--
R
--
D
EN
I
I
L
D
P
G
I
G
F
A
K
T
P
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
D
L
------
P
-
V
E
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
K
-
47
PsiBlast_CBE
76.84
31%
-102
- C4 -
3H2O
3
?
A:
[42-291]
------------------------------------------------------------------------------------------------------------------------
I
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
S
Y
N
E
V
D
-
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
---------
K
V
--
S
V
E
E
E
-
I
K
R
V
V
P
M
I
Q
A
V
S
K
--
E
V
K
--
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
-
A
H
Y
-
D
-
V
P
I
I
L
M
H
N
R
---------
D
N
M
N
Y
R
N
----------------------------
L
M
A
D
M
I
A
D
L
Y
D
S
I
K
--
I
A
K
D
A
G
V
--
R
--
D
EN
I
I
L
D
P
G
I
G
F
A
K
T
P
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
D
L
------
P
-
V
E
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
K
-