@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_1198: (2015-12-21 )
MRYQNMFETLKKHKKMAFIPFVTLGDPNYELSFEIVKTLIISGVSALELGLAFSDPVADGTTIQASHLRALKHASMAKNFQLLKKIRGYNHDIPIGLLAYANLIFSYGVDGFYAQAKECGVDSVLIADMPLIEKELVIKSAQKHQIKQIFIASPNASSKDLEQVATHSQGYIYTLARSGVTGASHTLENDASAIIKTLKTFSSTPALLGFGISKKEHITNAKGMGADGVICGSALVKIIEENLNNEDAMLEKIKGFVGGMIS
Atome Classification :
(44 SA)
.........10........20........30........40........50........60........70...-....-.80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
R
Y
Q
N
M
F
E
T
L
K
KHKK
M
A
F
I
P
F
V
T
LGDPN
Y
E
L
S
F
E
I
V
K
T
L
I
I
S
G
V
S
A
L
E
LGLAFSDPVADG
T
T
I
Q
A
S
H
L
R
A
L
K
H
A
-
S
M
A
K
-
N
F
Q
L
L
K
K
I
RGYNHDI
P
I
G
L
L
A
Y
A
N
L
I
F
SYGVD
G
F
Y
A
Q
A
K
ECGV
D
S
V
L
IADMP
L
I
E
K
E
L
V
I
K
S
AQKH
Q
I
K
Q
I
F
I
ASPNA
S
S
K
D
L
E
Q
V
A
THSQ
G
Y
I
Y
T
L
ARSGVTGASHTLE
N
D
A
S
A
I
I
K
T
L
K
T
FSSTPA
L
L
GFGIS
K
K
E
HITNAKGMGAD
G
V
I
C
G
S
A
L
V
K
I
I
E
E
NLN
N
E
D
A
M
L
E
K
I
K
G
F
VGGMIS
34
PsiBlast_CBE
95.61
48%
-126
- C2 -
2CLH
1
TRPA_SALTY
A:
[3-262]
-
R
Y
E
N
L
F
A
Q
L
N
D
R
R
E
G
A
F
V
P
F
V
T
L
G
D
P
G
I
E
Q
S
L
K
I
I
D
T
L
I
D
A
G
A
D
A
L
E
L
G
V
P
F
S
D
P
L
A
D
G
P
T
I
Q
N
A
N
L
R
A
F
A
A
G
V
T
P
A
Q
-
C
F
E
M
L
A
L
I
R
E
K
H
P
T
I
P
I
G
L
L
M
Y
A
N
L
V
F
N
N
G
I
D
A
F
Y
A
R
C
E
Q
V
G
V
D
S
V
L
V
A
D
V
P
V
E
E
S
A
P
F
R
Q
A
A
L
R
H
N
I
A
P
I
F
I
C
P
P
N
A
D
D
D
L
L
R
Q
V
A
S
Y
G
R
G
Y
T
Y
L
L
S
R
S
G
V
T
G
---------
H
H
L
I
E
K
L
K
E
Y
H
A
A
P
A
L
Q
G
F
G
I
S
S
P
E
Q
V
S
A
A
V
R
A
G
A
A
G
A
I
S
G
S
A
I
V
K
I
I
E
K
N
L
A
S
P
K
Q
M
L
A
E
L
R
S
F
V
S
A
M
K
A
28
PsiBlast_CBE
95.11
48%
-130
- C2 -
2RH9
1
TRPA_SALTY
A:
[3-262]
-
R
Y
E
N
L
F
A
Q
L
N
D
R
R
E
G
A
F
V
P
F
V
T
L
G
D
P
G
I
E
Q
S
L
K
I
I
D
T
L
I
D
A
G
A
D
A
L
E
L
G
V
P
F
S
D
P
L
A
D
G
P
T
I
Q
N
A
N
L
R
A
F
A
A
G
V
T
P
A
Q
-
C
F
E
M
L
A
L
I
R
E
K
H
P
T
I
P
I
G
L
L
M
Y
A
N
L
V
F
N
N
G
I
D
A
F
Y
A
R
C
E
Q
V
G
V
D
S
V
L
V
A
D
V
P
V
E
E
S
A
P
F
R
Q
A
A
L
R
H
N
I
A
P
I
F
I
C
P
P
N
A
D
D
D
L
L
R
Q
V
A
S
Y
G
R
G
Y
T
Y
L
L
S
--------------
L
H
H
L
I
E
K
L
K
E
Y
H
A
A
P
A
L
Q
G
F
G
I
S
S
P
E
Q
V
S
A
A
V
R
A
G
A
A
G
A
I
S
G
S
A
I
V
K
I
I
E
K
N
L
A
S
P
K
Q
M
L
A
E
L
R
S
F
V
S
A
M
K
A
30
PsiBlast_CBE
94.90
48%
-125
- C2 -
2CLO
1
TRPA_SALTY
A:
[3-262]
-
R
Y
E
N
L
F
A
Q
L
N
D
R
R
E
G
A
F
V
P
F
V
T
L
G
D
P
G
I
E
Q
S
L
K
I
I
D
T
L
I
D
A
G
A
D
A
L
E
L
G
V
P
F
S
D
P
L
A
D
G
P
T
I
Q
N
A
N
L
R
A
F
A
A
G
V
T
P
A
Q
-
C
F
E
M
L
A
L
I
R
E
K
H
P
T
I
P
I
G
L
L
M
Y
A
N
L
V
F
N
N
G
I
D
A
F
Y
A
R
C
E
Q
V
G
V
D
S
V
L
V
A
D
V
P
V
E
E
S
A
P
F
R
Q
A
A
L
R
H
N
I
A
P
I
F
I
C
P
P
N
A
D
D
D
L
L
R
Q
V
A
S
Y
G
R
G
Y
T
Y
L
L
S
R
S
G
V
T
G
---------
H
H
L
I
E
K
L
K
E
Y
H
A
A
P
A
L
Q
G
F
G
I
S
S
P
E
Q
V
S
A
A
V
R
A
G
A
A
G
A
I
S
G
S
A
I
V
K
I
I
E
K
N
L
A
S
P
K
Q
M
L
A
E
L
R
S
F
V
S
A
M
K
A
1
PsiBlast_PDB
94.67
48%
-125
- C2 -
1QOP
1
TRPA_SALTY
A:
[3-262]
-
R
Y
E
N
L
F
A
Q
L
N
D
R
R
E
G
A
F
V
P
F
V
T
L
G
D
P
G
I
E
Q
S
L
K
I
I
D
T
L
I
D
A
G
A
D
A
L
E
L
G
V
P
F
S
D
P
L
A
D
G
P
T
I
Q
N
A
N
L
R
A
F
A
A
G
V
T
P
A
Q
-
C
F
E
M
L
A
I
I
R
E
K
H
P
T
I
P
I
G
L
L
M
Y
A
N
L
V
F
N
N
G
I
D
A
F
Y
A
R
C
E
Q
V
G
V
D
S
V
L
V
A
D
V
P
V
E
E
S
A
P
F
R
Q
A
A
L
R
H
N
I
A
P
I
F
I
C
P
P
N
A
D
D
D
L
L
R
Q
V
A
S
Y
G
R
G
Y
T
Y
L
L
S
R
S
G
V
T
G
A
E
N
R
G
--
P
L
H
H
L
I
E
K
L
K
E
Y
H
A
A
P
A
L
Q
G
F
G
I
S
S
P
E
Q
V
S
A
A
V
R
A
G
A
A
G
A
I
S
G
S
A
I
V
K
I
I
E
K
N
L
A
S
P
K
Q
M
L
A
E
L
R
S
F
V
S
A
M
K
A
25
PsiBlast_CBE
94.53
48%
-125
- C2 -
4HN4
1
TRPA_SALTY
A:
[3-262]
-
R
Y
E
N
L
F
A
Q
L
N
D
R
R
E
G
A
F
V
P
F
V
T
L
G
D
P
G
I
E
Q
S
L
K
I
I
D
T
L
I
D
A
G
A
D
A
L
E
L
G
V
P
F
S
D
P
L
A
D
G
P
T
I
Q
N
A
N
L
R
A
F
A
A
G
V
T
P
A
Q
-
C
F
E
M
L
A
L
I
R
E
K
H
P
T
I
P
I
G
L
L
M
Y
A
N
L
V
F
N
N
G
I
D
A
F
Y
A
R
C
E
Q
V
G
V
D
S
V
L
V
A
D
V
P
V
E
E
S
A
P
F
R
Q
A
A
L
R
H
N
I
A
P
I
F
I
C
P
P
N
A
D
D
D
L
L
R
Q
V
A
S
Y
G
R
G
Y
T
Y
L
L
S
R
S
G
V
T
G
A
E
N
R
G
A
L
P
L
H
H
L
I
E
K
L
K
E
Y
H
A
A
P
A
L
Q
G
F
G
I
S
S
P
E
Q
V
S
A
A
V
R
A
G
A
A
G
A
I
S
G
S
A
I
V
K
I
I
E
K
N
L
A
S
P
K
Q
M
L
A
E
L
R
S
F
V
S
A
M
K
A
20
PsiBlast_PDB
94.38
48%
-123
- C2 -
1C29
1
TRPA_SALTY
A:
[3-262]
-
R
Y
E
N
L
F
A
Q
L
N
D
R
R
E
G
A
F
V
P
F
V
T
L
G
D
P
G
I
E
Q
S
L
K
I
I
D
T
L
I
D
A
G
A
D
A
L
E
L
G
V
P
F
S
D
P
L
A
D
G
P
T
I
Q
N
A
N
L
R
A
F
A
A
G
V
T
P
A
Q
-
C
F
E
M
L
A
L
I
R
E
K
H
P
T
I
P
I
G
L
L
M
Y
A
N
L
V
F
N
N
G
I
D
A
F
Y
A
R
C
E
Q
V
G
V
D
S
V
L
V
A
D
V
P
V
E
E
S
A
P
F
R
Q
A
A
L
R
H
N
I
A
P
I
F
I
C
P
P
N
A
D
D
D
L
L
R
Q
V
A
S
Y
G
R
G
Y
T
Y
L
L
S
R
S
G
V
T
G
A
E
N
R
G
--
P
L
H
H
L
I
E
K
L
K
E
Y
H
A
A
P
A
L
Q
G
F
G
I
S
S
P
E
Q
V
S
A
A
V
R
A
G
A
A
G
A
I
S
G
S
A
I
V
K
I
I
E
K
N
L
A
S
P
K
Q
M
L
A
E
L
R
S
F
V
S
A
M
K
A
46
PsiBlast_CBE
94.33
48%
-128
- C2 -
1KFB
1
TRPA_SALTY
A:
[3-262]
-
R
Y
E
N
L
F
A
Q
L
N
D
R
R
E
G
A
F
V
P
F
V
T
L
G
D
P
G
I
E
Q
S
L
K
I
I
D
T
L
I
D
A
G
A
D
A
L
E
L
G
V
P
F
S
D
P
L
A
D
G
P
T
I
Q
N
A
N
L
R
A
F
A
A
G
V
T
P
A
Q
-
C
F
E
M
L
A
L
I
R
E
K
H
P
T
I
P
I
G
L
L
M
Y
A
N
L
V
F
N
N
G
I
D
A
F
Y
A
R
C
E
Q
V
G
V
D
S
V
L
V
A
D
V
P
V
E
E
S
A
P
F
R
Q
A
A
L
R
H
N
I
A
P
I
F
I
C
P
P
N
A
D
D
D
L
L
R
Q
V
A
S
Y
G
R
G
Y
T
Y
L
L
S
R
-------------
L
H
H
L
I
E
K
L
K
E
Y
H
A
A
P
A
L
Q
G
F
G
I
S
S
P
E
Q
V
S
A
A
V
R
A
G
A
A
G
A
I
S
G
S
A
I
V
K
I
I
E
K
N
L
A
S
P
K
Q
M
L
A
E
L
R
S
F
V
S
A
M
K
A
42
PsiBlast_CBE
94.13
48%
-128
- C2 -
1K7E
1
TRPA_SALTY
A:
[3-262]
-
R
Y
E
N
L
F
A
Q
L
N
D
R
R
E
G
A
F
V
P
F
V
T
L
G
D
P
G
I
E
Q
S
L
K
I
I
D
T
L
I
D
A
G
A
D
A
L
E
L
G
V
P
F
S
D
P
L
A
D
G
P
T
I
Q
N
A
N
L
R
A
F
A
A
G
V
T
P
A
Q
-
C
F
E
M
L
A
L
I
R
E
K
H
P
T
I
P
I
G
L
L
M
Y
A
N
L
V
F
N
N
G
I
D
A
F
Y
A
R
C
E
Q
V
G
V
D
S
V
L
V
A
D
V
P
V
E
E
S
A
P
F
R
Q
A
A
L
R
H
N
I
A
P
I
F
I
C
P
P
N
A
D
D
D
L
L
R
Q
V
A
S
Y
G
R
G
Y
T
Y
L
L
S
R
S
G
V
T
G
-------
P
L
H
H
L
I
E
K
L
K
E
Y
H
A
A
P
A
L
Q
G
F
G
I
S
S
P
E
Q
V
S
A
A
V
R
A
G
A
A
G
A
I
S
G
S
A
I
V
K
I
I
E
K
N
L
A
S
P
K
Q
M
L
A
E
L
R
S
F
V
S
A
M
K
A
45
PsiBlast_CBE
94.08
48%
-122
- C2 -
1C8V
1
TRPA_SALTY
A:
[3-262]
-
R
Y
E
N
L
F
A
Q
L
N
D
R
R
E
G
A
F
V
P
F
V
T
L
G
D
P
G
I
E
Q
S
L
K
I
I
D
T
L
I
D
A
G
A
D
A
L
E
L
G
V
P
F
S
D
P
L
A
D
G
P
T
I
Q
N
A
N
L
R
A
F
A
A
G
V
T
P
A
Q
-
C
F
E
M
L
A
L
I
R
E
K
H
P
T
I
P
I
G
L
L
M
Y
A
N
L
V
F
N
N
G
I
D
A
F
Y
A
R
C
E
Q
V
G
V
D
S
V
L
V
A
D
V
P
V
E
E
S
A
P
F
R
Q
A
A
L
R
H
N
I
A
P
I
F
I
C
P
P
N
A
D
D
D
L
L
R
Q
V
A
S
Y
G
R
G
Y
T
Y
L
L
S
R
S
G
V
T
G
A
E
N
R
G
--
P
L
H
H
L
I
E
K
L
K
E
Y
H
A
A
P
A
L
Q
G
F
G
I
S
S
P
E
Q
V
S
A
A
V
R
A
G
A
A
G
A
I
S
G
S
A
I
V
K
I
I
E
K
N
L
A
S
P
K
Q
M
L
A
E
L
R
S
F
V
S
A
M
K
A
33
PsiBlast_CBE
94.02
48%
-126
- C2 -
2CLI
1
TRPA_SALTY
A:
[3-262]
-
R
Y
E
N
L
F
A
Q
L
N
D
R
R
E
G
A
F
V
P
F
V
T
L
G
D
P
G
I
E
Q
S
L
K
I
I
D
T
L
I
D
A
G
A
D
A
L
E
L
G
V
P
F
S
D
P
L
A
D
G
P
T
I
Q
N
A
N
L
R
A
F
A
A
G
V
T
P
A
Q
-
C
F
E
M
L
A
L
I
R
E
K
H
P
T
I
P
I
G
L
L
M
Y
A
N
L
V
F
N
N
G
I
D
A
F
Y
A
R
C
E
Q
V
G
V
D
S
V
L
V
A
D
V
P
V
E
E
S
A
P
F
R
Q
A
A
L
R
H
N
I
A
P
I
F
I
C
P
P
N
A
D
D
D
L
L
R
Q
V
A
S
Y
G
R
G
Y
T
Y
L
L
S
R
S
G
V
T
G
----------
H
L
I
E
K
L
K
E
Y
H
A
A
P
A
L
Q
G
F
G
I
S
S
P
E
Q
V
S
A
A
V
R
A
G
A
A
G
A
I
S
G
S
A
I
V
K
I
I
E
K
N
L
A
S
P
K
Q
M
L
A
E
L
R
S
F
V
S
A
M
K
A
7
PsiBlast_PDB
93.99
48%
-124
- C2 -
3PR2
1
TRPA_SALTY
A:
[2-261]
-
R
Y
E
N
L
F
A
Q
L
N
D
R
R
E
G
A
F
V
P
F
V
T
L
G
D
P
G
I
E
Q
S
L
K
I
I
D
T
L
I
D
A
G
A
D
A
L
E
L
G
V
P
F
S
D
P
L
A
D
G
P
T
I
Q
N
A
N
L
R
A
F
A
A
G
V
T
P
A
Q
-
C
F
E
M
L
A
L
I
R
E
K
H
P
T
I
P
I
G
L
L
M
Y
A
N
L
V
F
N
N
G
I
D
A
F
Y
A
R
C
E
Q
V
G
V
D
S
V
L
V
A
D
V
P
V
E
E
S
A
P
F
R
Q
A
A
L
R
H
N
I
A
P
I
F
I
C
P
P
N
A
D
D
D
L
L
R
Q
V
A
S
Y
G
R
G
Y
T
Y
L
L
S
R
S
G
V
T
G
A
E
N
R
G
A
L
P
L
H
H
L
I
E
K
L
K
E
Y
H
A
A
P
A
L
Q
G
F
G
I
S
S
P
E
Q
V
S
A
A
V
R
A
G
A
A
G
A
I
S
G
S
A
I
V
K
I
I
E
K
N
L
A
S
P
K
Q
M
L
A
E
L
R
S
F
V
S
A
M
K
A
37
PsiBlast_CBE
93.86
48%
-122
- C2 -
1TJP
1
TRPA_SALTY
A:
[3-262]
-
R
Y
E
N
L
F
A
Q
L
N
D
R
R
E
G
A
F
V
P
F
V
T
L
G
D
P
G
I
E
Q
S
L
K
I
I
D
T
L
I
D
A
G
A
D
A
L
E
L
G
V
P
F
S
D
P
L
A
D
G
P
T
I
Q
N
A
N
L
R
A
F
A
A
G
V
T
P
A
Q
-
C
F
E
M
L
A
L
I
R
E
K
H
P
T
I
P
I
G
L
L
M
Y
A
N
L
V
F
N
N
G
I
D
A
F
Y
A
R
C
E
Q
V
G
V
D
S
V
L
V
A
D
V
P
V
E
E
S
A
P
F
R
Q
A
A
L
R
H
N
I
A
P
I
F
I
C
P
P
N
A
D
D
D
L
L
R
Q
V
A
S
Y
G
R
G
Y
T
Y
L
L
S
R
S
G
V
T
G
A
E
N
R
G
A
L
P
L
H
H
L
I
E
K
L
K
E
Y
H
A
A
P
A
L
Q
G
F
G
I
S
S
P
E
Q
V
S
A
A
V
R
A
G
A
A
G
A
I
S
G
S
A
I
V
K
I
I
E
K
N
L
A
S
P
K
Q
M
L
A
E
L
R
S
F
V
S
A
M
K
A
4
PsiBlast_PDB
93.78
48%
-122
- C2 -
2CLK
1
TRPA_SALTY
A:
[3-262]
-
R
Y
E
N
L
F
A
Q
L
N
D
R
R
E
G
A
F
V
P
F
V
T
L
G
D
P
G
I
E
Q
S
L
K
I
I
D
T
L
I
D
A
G
A
D
A
L
E
L
G
V
P
F
S
D
P
L
A
D
G
P
T
I
Q
N
A
N
L
R
A
F
A
A
G
V
T
P
A
Q
-
C
F
E
M
L
A
I
I
R
E
K
H
P
T
I
P
I
G
L
L
M
Y
A
N
L
V
F
N
N
G
I
D
A
F
Y
A
R
C
E
Q
V
G
V
D
S
V
L
V
A
D
V
P
V
E
E
S
A
P
F
R
Q
A
A
L
R
H
N
I
A
P
I
F
I
C
P
P
N
A
D
D
D
L
L
R
Q
V
A
S
Y
G
R
G
Y
T
Y
L
L
S
R
S
G
V
T
G
A
E
N
R
G
A
L
P
L
H
H
L
I
E
K
L
K
E
Y
H
A
A
P
A
L
Q
G
F
G
I
S
S
P
E
Q
V
S
A
A
V
R
A
G
A
A
G
A
I
S
G
S
A
I
V
K
I
I
E
K
N
L
A
S
P
K
Q
M
L
A
E
L
R
S
F
V
S
A
M
K
A
3
PsiBlast_PDB
93.78
48%
-122
- C2 -
1WBJ
1
TRPA_SALTY
A:
[3-262]
-
R
Y
E
N
L
F
A
Q
L
N
D
R
R
E
G
A
F
V
P
F
V
T
L
G
D
P
G
I
E
Q
S
L
K
I
I
D
T
L
I
D
A
G
A
D
A
L
E
L
G
V
P
F
S
D
P
L
A
D
G
P
T
I
Q
N
A
N
L
R
A
F
A
A
G
V
T
P
A
Q
-
C
F
E
M
L
A
I
I
R
E
K
H
P
T
I
P
I
G
L
L
M
Y
A
N
L
V
F
N
N
G
I
D
A
F
Y
A
R
C
E
Q
V
G
V
D
S
V
L
V
A
D
V
P
V
E
E
S
A
P
F
R
Q
A
A
L
R
H
N
I
A
P
I
F
I
C
P
P
N
A
D
D
D
L
L
R
Q
V
A
S
Y
G
R
G
Y
T
Y
L
L
S
R
S
G
V
T
G
A
E
N
R
G
A
L
P
L
H
H
L
I
E
K
L
K
E
Y
H
A
A
P
A
L
Q
G
F
G
I
S
S
P
E
Q
V
S
A
A
V
R
A
G
A
A
G
A
I
S
G
S
A
I
V
K
I
I
E
K
N
L
A
S
P
K
Q
M
L
A
E
L
R
S
F
V
S
A
M
K
A
24
PsiBlast_CBE
93.74
48%
-124
- C2 -
4HPJ
3
TRPA_SALTY
A:
[3-262]
-
R
Y
E
N
L
F
A
Q
L
N
D
R
R
E
G
A
F
V
P
F
V
T
L
G
D
P
G
I
E
Q
S
L
K
I
I
D
T
L
I
D
A
G
A
D
A
L
E
L
G
V
P
F
S
D
P
L
A
D
G
P
T
I
Q
N
A
N
L
R
A
F
A
A
G
V
T
P
A
Q
-
C
F
E
M
L
A
L
I
R
E
K
H
P
T
I
P
I
G
L
L
M
Y
A
N
L
V
F
N
N
G
I
D
A
F
Y
A
R
C
E
Q
V
G
V
D
S
V
L
V
A
D
V
P
V
E
E
S
A
P
F
R
Q
A
A
L
R
H
N
I
A
P
I
F
I
C
P
P
N
A
D
D
D
L
L
R
Q
V
A
S
Y
G
R
G
Y
T
Y
L
L
S
R
S
G
V
T
G
A
E
N
R
G
A
L
P
L
H
H
L
I
E
K
L
K
E
Y
H
A
A
P
A
L
Q
G
F
G
I
S
S
P
E
Q
V
S
A
A
V
R
A
G
A
A
G
A
I
S
G
S
A
I
V
K
I
I
E
K
N
L
A
S
P
K
Q
M
L
A
E
L
R
S
F
V
S
A
M
K
A
2
PsiBlast_PDB
93.62
48%
-129
- C2 -
1K8X
-
TRPA_SALTY
A:
[3-262]
-
R
Y
E
N
L
F
A
Q
L
N
D
R
R
E
G
A
F
V
P
F
V
T
L
G
D
P
G
I
E
Q
S
L
K
I
I
D
T
L
I
D
A
G
A
D
A
L
E
L
G
V
P
F
S
D
P
L
A
D
G
P
T
I
Q
N
A
N
L
R
A
F
A
A
G
V
T
P
A
Q
-
C
F
E
M
L
A
I
I
R
E
K
H
P
T
I
P
I
G
L
L
M
Y
A
N
L
V
F
N
N
G
I
D
A
F
Y
A
R
C
E
Q
V
G
V
D
S
V
L
V
A
D
V
P
V
E
E
S
A
P
F
R
Q
A
A
L
R
H
N
I
A
P
I
F
I
C
P
P
N
A
D
D
D
L
L
R
Q
V
A
S
Y
G
R
G
Y
T
Y
L
L
------------------
L
I
E
K
L
K
E
Y
H
A
A
P
A
L
Q
G
F
G
I
S
S
P
E
Q
V
S
A
A
V
R
A
G
A
A
G
A
I
S
G
S
A
I
V
K
I
I
E
K
N
L
A
S
P
K
Q
M
L
A
E
L
R
S
F
V
S
A
M
K
A
21
PsiBlast_CBE
93.54
48%
-119
- C2 -
4KKX
6
TRPA_SALTY
A:
[3-262]
-
R
Y
E
N
L
F
A
Q
L
N
D
R
R
E
G
A
F
V
P
F
V
T
L
G
D
P
G
I
E
Q
S
L
K
I
I
D
T
L
I
D
A
G
A
D
A
L
E
L
G
V
P
F
S
D
P
L
A
D
G
P
T
I
Q
N
A
N
L
R
A
F
A
A
G
V
T
P
A
Q
-
C
F
E
M
L
A
L
I
R
E
K
H
P
T
I
P
I
G
L
L
M
Y
A
N
L
V
F
N
N
G
I
D
A
F
Y
A
R
C
E
Q
V
G
V
D
S
V
L
V
A
D
V
P
V
E
E
S
A
P
F
R
Q
A
A
L
R
H
N
I
A
P
I
F
I
C
P
P
N
A
D
D
D
L
L
R
Q
V
A
S
Y
G
R
G
Y
T
Y
L
L
S
R
S
G
V
T
G
A
E
N
R
G
A
L
P
L
H
H
L
I
E
K
L
K
E
Y
H
A
A
P
A
L
Q
G
F
G
I
S
S
P
E
Q
V
S
A
A
V
R
A
G
A
A
G
A
I
S
G
S
A
I
V
K
I
I
E
K
N
L
A
S
P
K
Q
M
L
A
E
L
R
S
F
V
S
A
M
K
A
38
PsiBlast_CBE
93.48
48%
-127
- C2 -
1QOQ
1
TRPA_SALTY
A:
[3-262]
-
R
Y
E
N
L
F
A
Q
L
N
D
R
R
E
G
A
F
V
P
F
V
T
L
G
D
P
G
I
E
Q
S
L
K
I
I
D
T
L
I
D
A
G
A
D
A
L
E
L
G
V
P
F
S
D
P
L
A
D
G
P
T
I
Q
N
A
N
L
R
A
F
A
A
G
V
T
P
A
Q
-
C
F
E
M
L
A
L
I
R
E
K
H
P
T
I
P
I
G
L
L
M
Y
A
N
L
V
F
N
N
G
I
D
A
F
Y
A
R
C
E
Q
V
G
V
D
S
V
L
V
A
D
V
P
V
E
E
S
A
P
F
R
Q
A
A
L
R
H
N
I
A
P
I
F
I
C
P
P
N
A
D
D
D
L
L
R
Q
V
A
S
Y
G
R
G
Y
T
Y
L
L
S
--------------
L
H
H
L
I
E
K
L
K
E
Y
H
A
A
P
A
L
Q
G
F
G
I
S
S
P
E
Q
V
S
A
A
V
R
A
G
A
A
G
A
I
S
G
S
A
I
V
K
I
I
E
K
N
L
A
S
P
K
Q
M
L
A
E
L
R
S
F
V
S
A
M
K
A
29
PsiBlast_CBE
93.31
48%
-124
- C2 -
2J9X
2
TRPA_SALTY
A:
[3-262]
-
R
Y
E
N
L
F
A
Q
L
N
D
R
R
E
G
A
F
V
P
F
V
T
L
G
D
P
G
I
E
Q
S
L
K
I
I
D
T
L
I
D
A
G
A
D
A
L
E
L
G
V
P
F
S
D
P
L
A
D
G
P
T
I
Q
N
A
N
L
R
A
F
A
A
G
V
T
P
A
Q
-
C
F
E
M
L
A
L
I
R
E
K
H
P
T
I
P
I
G
L
L
M
Y
A
N
L
V
F
N
N
G
I
D
A
F
Y
A
R
C
E
Q
V
G
V
D
S
V
L
V
A
D
V
P
V
E
E
S
A
P
F
R
Q
A
A
L
R
H
N
I
A
P
I
F
I
C
P
P
N
A
D
D
D
L
L
R
Q
V
A
S
Y
G
R
G
Y
T
Y
L
L
S
R
S
G
V
T
G
A
E
N
R
G
---
L
H
H
L
I
E
K
L
K
E
Y
H
A
A
P
A
L
Q
G
F
G
I
S
S
P
E
Q
V
S
A
A
V
R
A
G
A
A
G
A
I
S
G
S
A
I
V
K
I
I
E
K
N
L
A
S
P
K
Q
M
L
A
E
L
R
S
F
V
S
A
M
K
A
17
PsiBlast_PDB
93.31
48%
-122
- C2 -
1C9D
1
TRPA_SALTY
A:
[3-262]
-
R
Y
E
N
L
F
A
Q
L
N
D
R
R
E
G
A
F
V
P
F
V
T
L
G
D
P
G
I
E
Q
S
L
K
I
I
D
T
L
I
D
A
G
A
D
A
L
E
L
G
V
P
F
S
D
P
L
A
D
G
P
T
I
Q
N
A
N
L
R
A
F
A
A
G
V
T
P
A
Q
-
C
F
E
M
L
A
L
I
R
E
K
H
P
T
I
P
I
G
L
L
M
Y
A
N
L
V
F
N
N
G
I
D
A
F
Y
A
R
C
E
Q
V
G
V
D
S
V
L
V
A
D
V
P
V
E
E
S
A
P
F
R
Q
A
A
L
R
H
N
I
A
P
I
F
I
C
P
P
N
A
D
D
D
L
L
R
Q
V
A
S
Y
G
R
G
Y
T
Y
L
L
S
R
S
G
V
T
G
A
E
N
R
G
--
P
L
H
H
L
I
E
K
L
K
E
Y
H
A
A
P
A
L
Q
G
F
G
I
S
S
P
E
Q
V
S
A
A
V
R
A
G
A
A
G
A
I
S
G
S
A
I
V
K
I
I
E
K
N
L
A
S
P
K
Q
M
L
A
E
L
R
S
F
V
S
A
M
K
A
6
PsiBlast_PDB
93.26
48%
-122
- C2 -
3CEP
1
TRPA_SALTY
A:
[3-262]
-
R
Y
E
N
L
F
A
Q
L
N
D
R
R
E
G
A
F
V
P
F
V
T
L
G
D
P
G
I
E
Q
S
L
K
I
I
D
T
L
I
D
A
G
A
D
A
L
E
L
G
V
P
F
S
D
P
L
A
D
G
P
T
I
Q
N
A
N
L
R
A
F
A
A
G
V
T
P
A
Q
-
C
F
E
M
L
A
I
I
R
E
K
H
P
T
I
P
I
G
L
L
M
Y
A
N
L
V
F
N
N
G
I
D
A
F
Y
A
R
C
E
Q
V
G
V
D
S
V
L
V
A
D
V
P
V
E
E
S
A
P
F
R
Q
A
A
L
R
H
N
I
A
P
I
F
I
C
P
P
N
A
D
D
D
L
L
R
Q
V
A
S
Y
G
R
G
Y
T
Y
L
L
S
R
S
G
V
T
G
A
E
N
R
G
A
L
P
L
H
H
L
I
E
K
L
K
E
Y
H
A
A
P
A
L
Q
G
F
G
I
S
S
P
E
Q
V
S
A
A
V
R
A
G
A
A
G
A
I
S
G
S
A
I
V
K
I
I
E
K
N
L
A
S
P
K
Q
M
L
A
E
L
R
S
F
V
S
A
M
K
A
47
PsiBlast_CBE
93.22
48%
-128
- C2 -
1KFC
1
TRPA_SALTY
A:
[3-262]
-
R
Y
E
N
L
F
A
Q
L
N
D
R
R
E
G
A
F
V
P
F
V
T
L
G
D
P
G
I
E
Q
S
L
K
I
I
D
T
L
I
D
A
G
A
D
A
L
E
L
G
V
P
F
S
D
P
L
A
D
G
P
T
I
Q
N
A
N
L
R
A
F
A
A
G
V
T
P
A
Q
-
C
F
E
M
L
A
I
I
R
E
K
H
P
T
I
P
I
G
L
L
M
Y
A
N
L
V
F
N
N
G
I
D
A
F
Y
A
R
C
E
Q
V
G
V
D
S
V
L
V
A
D
V
P
V
E
E
S
A
P
F
R
Q
A
A
L
R
H
N
I
A
P
I
F
I
C
P
P
N
A
D
D
D
L
L
R
Q
V
A
S
Y
G
R
G
Y
T
Y
L
L
S
--------------
L
H
H
L
I
E
K
L
K
E
Y
H
A
A
P
A
L
Q
G
F
G
I
S
S
P
E
Q
V
S
A
A
V
R
A
G
A
A
G
A
I
S
G
S
A
I
V
K
I
I
E
K
N
L
A
S
P
K
Q
M
L
A
E
L
R
S
F
V
S
A
M
K
A
41
PsiBlast_CBE
93.20
48%
-130
- C2 -
1K7F
1
TRPA_SALTY
A:
[3-262]
-
R
Y
E
N
L
F
A
Q
L
N
D
R
R
E
G
A
F
V
P
F
V
T
L
G
D
P
G
I
E
Q
S
L
K
I
I
D
T
L
I
D
A
G
A
D
A
L
E
L
G
V
P
F
S
D
P
L
A
D
G
P
T
I
Q
N
A
N
L
R
A
F
A
A
G
V
T
P
A
Q
-
C
F
E
M
L
A
L
I
R
E
K
H
P
T
I
P
I
G
L
L
M
Y
A
N
L
V
F
N
N
G
I
D
A
F
Y
A
R
C
E
Q
V
G
V
D
S
V
L
V
A
D
V
P
V
E
E
S
A
P
F
R
Q
A
A
L
R
H
N
I
A
P
I
F
I
C
P
P
N
A
D
D
D
L
L
R
Q
V
A
S
Y
G
R
G
Y
T
Y
L
L
S
--------------
L
H
H
L
I
E
K
L
K
E
Y
H
A
A
P
A
L
Q
G
F
G
I
S
S
P
E
Q
V
S
A
A
V
R
A
G
A
A
G
A
I
S
G
S
A
I
V
K
I
I
E
K
N
L
A
S
P
K
Q
M
L
A
E
L
R
S
F
V
S
A
M
K
A
40
PsiBlast_CBE
93.18
48%
-128
- C2 -
1K8Y
1
TRPA_SALTY
A:
[3-262]
-
R
Y
E
N
L
F
A
Q
L
N
D
R
R
E
G
A
F
V
P
F
V
T
L
G
D
P
G
I
E
Q
S
L
K
I
I
D
T
L
I
D
A
G
A
D
A
L
E
L
G
V
P
F
S
D
P
L
A
D
G
P
T
I
Q
N
A
N
L
R
A
F
A
A
G
V
T
P
A
Q
-
C
F
E
M
L
A
L
I
R
E
K
H
P
T
I
P
I
G
L
L
M
Y
A
N
L
V
F
N
N
G
I
D
A
F
Y
A
R
C
E
Q
V
G
V
D
S
V
L
V
A
D
V
P
V
E
E
S
A
P
F
R
Q
A
A
L
R
H
N
I
A
P
I
F
I
C
P
P
N
A
D
D
D
L
L
R
Q
V
A
S
Y
G
R
G
Y
T
Y
L
L
S
-------------
P
L
H
H
L
I
E
K
L
K
E
Y
H
A
A
P
A
L
Q
G
F
G
I
S
S
P
E
Q
V
S
A
A
V
R
A
G
A
A
G
A
I
S
G
S
A
I
V
K
I
I
E
K
N
L
A
S
P
K
Q
M
L
A
E
L
R
S
F
V
S
A
M
K
A
49
PsiBlast_CBE
93.11
48%
-130
- C2 -
1A5B
1
TRPA_SALTY
A:
[3-262]
-
R
Y
E
N
L
F
A
Q
L
N
D
R
R
E
G
A
F
V
P
F
V
T
L
G
D
P
G
I
E
Q
S
L
K
I
I
D
T
L
I
D
A
G
A
D
A
L
E
L
G
V
P
F
S
D
P
L
A
N
G
P
T
I
Q
N
A
N
L
R
A
F
A
A
G
V
T
P
A
Q
-
C
F
E
M
L
A
L
I
R
E
K
H
P
T
I
P
I
G
L
L
M
Y
A
N
L
V
F
N
N
G
I
D
A
F
Y
A
R
C
E
Q
V
G
V
D
S
V
L
V
A
D
V
P
V
E
E
S
A
P
F
R
Q
A
A
L
R
H
N
I
A
P
I
F
I
C
P
P
N
A
D
D
D
L
L
R
Q
V
A
S
Y
G
R
G
Y
T
Y
L
L
-------------------
I
E
K
L
K
E
Y
H
A
A
P
A
L
Q
G
F
G
I
S
S
P
E
Q
V
S
A
A
V
R
A
G
A
A
G
A
I
S
G
S
A
I
V
K
I
I
E
K
N
L
A
S
P
K
Q
M
L
A
E
L
R
S
F
V
S
A
M
K
A
32
PsiBlast_CBE
93.03
48%
-121
- C2 -
2CLL
1
TRPA_SALTY
A:
[3-262]
-
R
Y
E
N
L
F
A
Q
L
N
D
R
R
E
G
A
F
V
P
F
V
T
L
G
D
P
G
I
E
Q
S
L
K
I
I
D
T
L
I
D
A
G
A
D
A
L
E
L
G
V
P
F
S
D
P
L
A
D
G
P
T
I
Q
N
A
N
L
R
A
F
A
A
G
V
T
P
A
Q
-
C
F
E
M
L
A
L
I
R
E
K
H
P
T
I
P
I
G
L
L
M
Y
A
N
L
V
F
N
N
G
I
D
A
F
Y
A
R
C
E
Q
V
G
V
D
S
V
L
V
A
D
V
P
V
E
E
S
A
P
F
R
Q
A
A
L
R
H
N
I
A
P
I
F
I
C
P
P
N
A
D
D
D
L
L
R
Q
V
A
S
Y
G
R
G
Y
T
Y
L
L
S
R
S
G
V
T
G
---------
H
H
L
I
E
K
L
K
E
Y
H
A
A
P
A
L
Q
G
F
G
I
S
S
P
E
Q
V
S
A
A
V
R
A
G
A
A
G
A
I
S
G
S
A
I
V
K
I
I
E
K
N
L
A
S
P
K
Q
M
L
A
E
L
R
S
F
V
S
A
M
K
A
23
PsiBlast_CBE
93.03
48%
-123
- C2 -
4HPX
4
TRPA_SALTY
A:
[3-262]
-
R
Y
E
N
L
F
A
Q
L
N
D
R
R
E
G
A
F
V
P
F
V
T
L
G
D
P
G
I
E
Q
S
L
K
I
I
D
T
L
I
D
A
G
A
D
A
L
E
L
G
V
P
F
S
D
P
L
A
D
G
P
T
I
Q
N
A
N
L
R
A
F
A
A
G
V
T
P
A
Q
-
C
F
E
M
L
A
L
I
R
E
K
H
P
T
I
P
I
G
L
L
M
Y
A
N
L
V
F
N
N
G
I
D
A
F
Y
A
R
C
E
Q
V
G
V
D
S
V
L
V
A
D
V
P
V
E
E
S
A
P
F
R
Q
A
A
L
R
H
N
I
A
P
I
F
I
C
P
P
N
A
D
D
D
L
L
R
Q
V
A
S
Y
G
R
G
Y
T
Y
L
L
S
R
S
G
V
T
G
A
E
N
R
G
A
L
P
L
H
H
L
I
E
K
L
K
E
Y
H
A
A
P
A
L
Q
G
F
G
I
S
S
P
E
Q
V
S
A
A
V
R
A
G
A
A
G
A
I
S
G
S
A
I
V
K
I
I
E
K
N
L
A
S
P
K
Q
M
L
A
E
L
R
S
F
V
S
A
M
K
A
36
PsiBlast_CBE
93.02
48%
-128
- C2 -
2CLE
1
TRPA_SALTY
A:
[3-262]
-
R
Y
E
N
L
F
A
Q
L
N
D
R
R
E
G
A
F
V
P
F
V
T
L
G
D
P
G
I
E
Q
S
L
K
I
I
D
T
L
I
D
A
G
A
D
A
L
E
L
G
V
P
F
S
D
P
L
A
D
G
P
T
I
Q
N
A
N
L
R
A
F
A
A
G
V
T
P
A
Q
-
C
F
E
M
L
A
L
I
R
E
K
H
P
T
I
P
I
G
L
L
M
Y
A
N
L
V
F
N
N
G
I
D
A
F
Y
A
R
C
E
Q
V
G
V
D
S
V
L
V
A
D
V
P
V
E
E
S
A
P
F
R
Q
A
A
L
R
H
N
I
A
P
I
F
I
C
P
P
N
A
D
D
D
L
L
R
Q
V
A
S
Y
G
R
G
Y
T
Y
L
L
S
---------------
H
H
L
I
E
K
L
K
E
Y
H
A
A
P
A
L
Q
G
F
G
I
S
S
P
E
Q
V
S
A
A
V
R
A
G
A
A
G
A
I
S
G
S
A
I
V
K
I
I
E
K
N
L
A
S
P
K
Q
M
L
A
E
L
R
S
F
V
S
A
M
K
A
22
PsiBlast_CBE
92.93
48%
-121
- C2 -
4HT3
9
TRPA_SALTY
A:
[3-262]
-
R
Y
E
N
L
F
A
Q
L
N
D
R
R
E
G
A
F
V
P
F
V
T
L
G
D
P
G
I
E
Q
S
L
K
I
I
D
T
L
I
D
A
G
A
D
A
L
E
L
G
V
P
F
S
D
P
L
A
D
G
P
T
I
Q
N
A
N
L
R
A
F
A
A
G
V
T
P
A
Q
-
C
F
E
M
L
A
L
I
R
E
K
H
P
T
I
P
I
G
L
L
M
Y
A
N
L
V
F
N
N
G
I
D
A
F
Y
A
R
C
E
Q
V
G
V
D
S
V
L
V
A
D
V
P
V
E
E
S
A
P
F
R
Q
A
A
L
R
H
N
I
A
P
I
F
I
C
P
P
N
A
D
D
D
L
L
R
Q
V
A
S
Y
G
R
G
Y
T
Y
L
L
S
R
S
G
V
T
G
A
E
N
R
G
A
L
P
L
H
H
L
I
E
K
L
K
E
Y
H
A
A
P
A
L
Q
G
F
G
I
S
S
P
E
Q
V
S
A
A
V
R
A
G
A
A
G
A
I
S
G
S
A
I
V
K
I
I
E
K
N
L
A
S
P
K
Q
M
L
A
E
L
R
S
F
V
S
A
M
K
A
18
PsiBlast_PDB
92.84
48%
-123
- C2 -
1CW2
1
TRPA_SALTY
A:
[3-262]
-
R
Y
E
N
L
F
A
Q
L
N
D
R
R
E
G
A
F
V
P
F
V
T
L
G
D
P
G
I
E
Q
S
L
K
I
I
D
T
L
I
D
A
G
A
D
A
L
E
L
G
V
P
F
S
D
P
L
A
D
G
P
T
I
Q
N
A
N
L
R
A
F
A
A
G
V
T
P
A
Q
-
C
F
E
M
L
A
L
I
R
E
K
H
P
T
I
P
I
G
L
L
M
Y
A
N
L
V
F
N
N
G
I
D
A
F
Y
A
R
C
E
Q
V
G
V
D
S
V
L
V
A
D
V
P
V
E
E
S
A
P
F
R
Q
A
A
L
R
H
N
I
A
P
I
F
I
C
P
P
N
A
D
D
D
L
L
R
Q
V
A
S
Y
G
R
G
Y
T
Y
L
L
S
R
S
G
V
T
G
A
E
N
R
G
--
P
L
H
H
L
I
E
K
L
K
E
Y
H
A
A
P
A
L
Q
G
F
G
I
S
S
P
E
Q
V
S
A
A
V
R
A
G
A
A
G
A
I
S
G
S
A
I
V
K
I
I
E
K
N
L
A
S
P
K
Q
M
L
A
E
L
R
S
F
V
S
A
M
K
A
13
PsiBlast_PDB
92.84
48%
-125
- C2 -
1A50
1
TRPA_SALTY
A:
[3-262]
-
R
Y
E
N
L
F
A
Q
L
N
D
R
R
E
G
A
F
V
P
F
V
T
L
G
D
P
G
I
E
Q
S
L
K
I
I
D
T
L
I
D
A
G
A
D
A
L
E
L
G
V
P
F
S
D
P
L
A
D
G
P
T
I
Q
N
A
N
L
R
A
F
A
A
G
V
T
P
A
Q
-
C
F
E
M
L
A
L
I
R
E
K
H
P
T
I
P
I
G
L
L
M
Y
A
N
L
V
F
N
N
G
I
D
A
F
Y
A
R
C
E
Q
V
G
V
D
S
V
L
V
A
D
V
P
V
E
E
S
A
P
F
R
Q
A
A
L
R
H
N
I
A
P
I
F
I
C
P
P
N
A
D
D
D
L
L
R
Q
V
A
S
Y
G
R
G
Y
T
Y
L
L
S
R
S
G
V
T
G
A
E
N
------
H
H
L
I
E
K
L
K
E
Y
H
A
A
P
A
L
Q
G
F
G
I
S
S
P
E
Q
V
S
A
A
V
R
A
G
A
A
G
A
I
S
G
S
A
I
V
K
I
I
E
K
N
L
A
S
P
K
Q
M
L
A
E
L
R
S
F
V
S
A
M
K
A
44
PsiBlast_CBE
92.66
48%
-122
- C2 -
1FUY
1
TRPA_SALTY
A:
[3-262]
-
R
Y
E
N
L
F
A
Q
L
N
D
R
R
E
G
A
F
V
P
F
V
T
L
G
D
P
G
I
E
Q
S
L
K
I
I
D
T
L
I
D
A
G
A
D
A
L
E
L
G
V
P
F
S
D
P
L
A
D
G
P
T
I
Q
N
A
N
L
R
A
F
A
A
G
V
T
P
A
Q
-
C
F
E
M
L
A
L
I
R
E
K
H
P
T
I
P
I
G
L
L
M
Y
A
N
L
V
F
N
N
G
I
D
A
F
Y
A
R
C
E
Q
V
G
V
D
S
V
L
V
A
D
V
P
V
E
E
S
A
P
F
R
Q
A
A
L
R
H
N
I
A
P
I
F
I
C
P
P
N
A
D
D
D
L
L
R
Q
V
A
S
Y
G
R
G
Y
T
Y
L
L
S
R
S
G
V
T
G
A
E
N
-----
L
H
H
L
I
E
K
L
K
E
Y
H
A
A
P
A
L
Q
G
F
G
I
S
S
P
E
Q
V
S
A
A
V
R
A
G
A
A
G
A
I
S
G
S
A
I
V
K
I
I
E
K
N
L
A
S
P
K
Q
M
L
A
E
L
R
S
F
V
S
A
M
K
A
31
PsiBlast_CBE
92.62
48%
-128
- C2 -
2CLM
1
TRPA_SALTY
A:
[3-262]
-
R
Y
E
N
L
F
A
Q
L
N
D
R
R
E
G
A
F
V
P
F
V
T
L
G
D
P
G
I
E
Q
S
L
K
I
I
D
T
L
I
D
A
G
A
D
A
L
E
L
G
V
P
F
S
D
P
L
A
D
G
P
T
I
Q
N
A
N
L
R
A
F
A
A
G
V
T
P
A
Q
-
C
F
E
M
L
A
L
I
R
E
K
H
P
T
I
P
I
G
L
L
M
Y
A
N
L
V
F
N
N
G
I
D
A
F
Y
A
R
C
E
Q
V
G
V
D
S
V
L
V
A
D
V
P
V
E
E
S
A
P
F
R
Q
A
A
L
R
H
N
I
A
P
I
F
I
C
P
P
N
A
D
D
D
L
L
R
Q
V
A
S
Y
G
R
G
Y
T
Y
L
L
S
---------------
H
H
L
I
E
K
L
K
E
Y
H
A
A
P
A
L
Q
G
F
G
I
S
S
P
E
Q
V
S
A
A
V
R
A
G
A
A
G
A
I
S
G
S
A
I
V
K
I
I
E
K
N
L
A
S
P
K
Q
M
L
A
E
L
R
S
F
V
S
A
M
K
A
19
PsiBlast_PDB
92.51
48%
-122
- C2 -
1CX9
1
TRPA_SALTY
A:
[3-262]
-
R
Y
E
N
L
F
A
Q
L
N
D
R
R
E
G
A
F
V
P
F
V
T
L
G
D
P
G
I
E
Q
S
L
K
I
I
D
T
L
I
D
A
G
A
D
A
L
E
L
G
V
P
F
S
D
P
L
A
D
G
P
T
I
Q
N
A
N
L
R
A
F
A
A
G
V
T
P
A
Q
-
C
F
E
M
L
A
L
I
R
E
K
H
P
T
I
P
I
G
L
L
M
Y
A
N
L
V
F
N
N
G
I
D
A
F
Y
A
R
C
E
Q
V
G
V
D
S
V
L
V
A
D
V
P
V
E
E
S
A
P
F
R
Q
A
A
L
R
H
N
I
A
P
I
F
I
C
P
P
N
A
D
D
D
L
L
R
Q
V
A
S
Y
G
R
G
Y
T
Y
L
L
S
R
S
G
V
T
G
A
E
N
R
G
--
P
L
H
H
L
I
E
K
L
K
E
Y
H
A
A
P
A
L
Q
G
F
G
I
S
S
P
E
Q
V
S
A
A
V
R
A
G
A
A
G
A
I
S
G
S
A
I
V
K
I
I
E
K
N
L
A
S
P
K
Q
M
L
A
E
L
R
S
F
V
S
A
M
K
A
43
PsiBlast_CBE
92.43
48%
-122
- C2 -
1K3U
1
TRPA_SALTY
A:
[3-262]
-
R
Y
E
N
L
F
A
Q
L
N
D
R
R
E
G
A
F
V
P
F
V
T
L
G
D
P
G
I
E
Q
S
L
K
I
I
D
T
L
I
D
A
G
A
D
A
L
E
L
G
V
P
F
S
D
P
L
A
D
G
P
T
I
Q
N
A
N
L
R
A
F
A
A
G
V
T
P
A
Q
-
C
F
E
M
L
A
L
I
R
E
K
H
P
T
I
P
I
G
L
L
M
Y
A
N
L
V
F
N
N
G
I
D
A
F
Y
A
R
C
E
Q
V
G
V
D
S
V
L
V
A
D
V
P
V
E
E
S
A
P
F
R
Q
A
A
L
R
H
N
I
A
P
I
F
I
C
P
P
N
A
D
D
D
L
L
R
Q
V
A
S
Y
G
R
G
Y
T
Y
L
L
S
R
S
G
V
T
G
A
E
N
R
G
A
L
P
L
H
H
L
I
E
K
L
K
E
Y
H
A
A
P
A
L
Q
G
F
G
I
S
S
P
E
Q
V
S
A
A
V
R
A
G
A
A
G
A
I
S
G
S
A
I
V
K
I
I
E
K
N
L
A
S
P
K
Q
M
L
A
E
L
R
S
F
V
S
A
M
K
A
14
PsiBlast_PDB
92.39
48%
-124
- C2 -
1A5S
1
TRPA_SALTY
A:
[3-262]
-
R
Y
E
N
L
F
A
Q
L
N
D
R
R
E
G
A
F
V
P
F
V
T
L
G
D
P
G
I
E
Q
S
L
K
I
I
D
T
L
I
D
A
G
A
D
A
L
E
L
G
V
P
F
S
D
P
L
A
D
G
P
T
I
Q
N
A
N
L
R
A
F
A
A
G
V
T
P
A
Q
-
C
F
E
M
L
A
L
I
R
E
K
H
P
T
I
P
I
G
L
L
M
Y
A
N
L
V
F
N
N
G
I
D
A
F
Y
A
R
C
E
Q
V
G
V
D
S
V
L
V
A
D
V
P
V
E
E
S
A
P
F
R
Q
A
A
L
R
H
N
I
A
P
I
F
I
C
P
P
N
A
D
D
D
L
L
R
Q
V
A
S
Y
G
R
G
Y
T
Y
L
L
S
R
S
G
V
T
G
A
E
N
--------
L
I
E
K
L
K
E
Y
H
A
A
P
A
L
Q
G
F
G
I
S
S
P
E
Q
V
S
A
A
V
R
A
G
A
A
G
A
I
S
G
S
A
I
V
K
I
I
E
K
N
L
A
S
P
K
Q
M
L
A
E
L
R
S
F
V
S
A
M
K
A
27
PsiBlast_CBE
92.35
48%
-128
- C2 -
2RHG
1
TRPA_SALTY
A:
[3-262]
-
R
Y
E
N
L
F
A
Q
L
N
D
R
R
E
G
A
F
V
P
F
V
T
L
G
D
P
G
I
E
Q
S
L
K
I
I
D
T
L
I
D
A
G
A
D
A
L
E
L
G
V
P
F
S
D
P
L
A
D
G
P
T
I
Q
N
A
N
L
R
A
F
A
A
G
V
T
P
A
Q
-
C
F
E
M
L
A
L
I
R
E
K
H
P
T
I
P
I
G
L
L
M
Y
A
N
L
V
F
N
N
G
I
D
A
F
Y
A
R
C
E
Q
V
G
V
D
S
V
L
V
A
D
V
P
V
E
E
S
A
P
F
R
Q
A
A
L
R
H
N
I
A
P
I
F
I
C
P
P
N
A
D
D
D
L
L
R
Q
V
A
S
Y
G
R
G
Y
T
Y
L
L
S
-----------------
L
I
E
K
L
K
E
Y
H
A
A
P
A
L
Q
G
F
G
I
S
S
P
E
Q
V
S
A
A
V
R
A
G
A
A
G
A
I
S
G
S
A
I
V
K
I
I
E
K
N
L
A
S
P
K
Q
M
L
A
E
L
R
S
F
V
S
A
M
K
A
39
PsiBlast_CBE
92.25
48%
-127
- C2 -
1K8Z
1
TRPA_SALTY
A:
[3-262]
-
R
Y
E
N
L
F
A
Q
L
N
D
R
R
E
G
A
F
V
P
F
V
T
L
G
D
P
G
I
E
Q
S
L
K
I
I
D
T
L
I
D
A
G
A
D
A
L
E
L
G
V
P
F
S
D
P
L
A
D
G
P
T
I
Q
N
A
N
L
R
A
F
A
A
G
V
T
P
A
Q
-
C
F
E
M
L
A
L
I
R
E
K
H
P
T
I
P
I
G
L
L
M
Y
A
N
L
V
F
N
N
G
I
D
A
F
Y
A
R
C
E
Q
V
G
V
D
S
V
L
V
A
D
V
P
V
E
E
S
A
P
F
R
Q
A
A
L
R
H
N
I
A
P
I
F
I
C
P
P
N
A
D
D
D
L
L
R
Q
V
A
S
Y
G
R
G
Y
T
Y
L
L
S
-----------
A
L
P
L
H
H
L
I
E
K
L
K
E
Y
H
A
A
P
A
L
Q
G
F
G
I
S
S
P
E
Q
V
S
A
A
V
R
A
G
A
A
G
A
I
S
G
S
A
I
V
K
I
I
E
K
N
L
A
S
P
K
Q
M
L
A
E
L
R
S
F
V
S
A
M
K
A
35
PsiBlast_CBE
92.17
48%
-128
- C2 -
2CLF
1
TRPA_SALTY
A:
[3-262]
-
R
Y
E
N
L
F
A
Q
L
N
D
R
R
E
G
A
F
V
P
F
V
T
L
G
D
P
G
I
E
Q
S
L
K
I
I
D
T
L
I
D
A
G
A
D
A
L
E
L
G
V
P
F
S
D
P
L
A
D
G
P
T
I
Q
N
A
N
L
R
A
F
A
A
G
V
T
P
A
Q
-
C
F
E
M
L
A
L
I
R
E
K
H
P
T
I
P
I
G
L
L
M
Y
A
N
L
V
F
N
N
G
I
D
A
F
Y
A
R
C
E
Q
V
G
V
D
S
V
L
V
A
D
V
P
V
E
E
S
A
P
F
R
Q
A
A
L
R
H
N
I
A
P
I
F
I
C
P
P
N
A
D
D
D
L
L
R
Q
V
A
S
Y
G
R
G
Y
T
Y
L
L
S
---------------
H
H
L
I
E
K
L
K
E
Y
H
A
A
P
A
L
Q
G
F
G
I
S
S
P
E
Q
V
S
A
A
V
R
A
G
A
A
G
A
I
S
G
S
A
I
V
K
I
I
E
K
N
L
A
S
P
K
Q
M
L
A
E
L
R
S
F
V
S
A
M
K
A
12
PsiBlast_PDB
91.35
48%
-124
- C2 -
2TRS
1
TRPA_SALTY
A:
[3-262]
-
R
Y
E
N
L
F
A
Q
L
N
D
R
R
E
G
A
F
V
P
F
V
T
L
G
D
P
G
I
E
Q
S
L
K
I
I
D
T
L
I
D
A
G
A
D
A
L
E
L
G
V
P
F
S
D
P
L
A
D
G
P
T
I
Q
N
A
N
L
R
A
F
A
A
G
V
T
P
A
Q
-
C
F
E
M
L
A
L
I
R
E
K
H
P
T
I
P
I
G
L
L
M
Y
A
N
L
V
F
N
N
G
I
D
A
F
Y
A
R
C
E
Q
V
G
V
D
S
V
L
V
A
D
V
P
V
E
E
S
A
P
F
R
Q
A
A
L
R
H
N
I
A
P
I
F
I
C
P
P
N
A
D
D
D
L
L
R
Q
V
A
S
Y
G
R
G
Y
T
Y
L
L
S
R
S
G
V
T
G
A
E
N
------
H
H
L
I
E
K
L
K
E
Y
H
A
A
P
A
L
Q
G
F
G
I
S
S
P
E
Q
V
S
A
A
V
R
A
G
A
A
G
A
I
S
G
S
A
I
V
K
I
I
E
K
N
L
A
S
P
K
Q
M
L
A
E
L
R
S
F
V
S
A
M
K
A
26
PsiBlast_CBE
90.70
48%
-119
- C2 -
2TSY
1
TRPA_SALTY
A:
[3-262]
-
R
Y
E
N
L
F
A
Q
L
N
D
R
R
E
G
A
F
V
P
F
V
T
L
G
D
P
G
I
E
Q
S
L
K
I
I
D
T
L
I
D
A
G
A
D
A
L
E
L
G
V
P
F
S
D
P
L
A
D
G
P
T
I
Q
N
A
N
L
R
A
F
A
A
G
V
T
P
A
Q
-
C
F
E
M
L
A
L
I
R
E
K
H
P
T
I
P
I
G
L
L
M
Y
A
N
L
V
F
N
N
G
I
D
A
F
Y
A
R
C
E
Q
V
G
V
D
S
V
L
V
A
D
V
P
V
E
E
S
A
P
F
R
Q
A
A
L
R
H
N
I
A
P
I
F
I
C
P
P
N
A
D
D
D
L
L
R
Q
V
A
S
Y
G
R
G
Y
T
Y
L
L
S
R
S
G
V
T
G
A
E
N
------
H
H
L
I
E
K
L
K
E
Y
H
A
A
P
A
L
Q
G
F
G
I
S
S
P
E
Q
V
S
A
A
V
R
A
G
A
A
G
A
I
S
G
S
A
I
V
K
I
I
E
K
N
L
A
S
P
K
Q
M
L
A
E
L
R
S
F
V
S
A
M
K
A
48
PsiBlast_CBE
90.47
48%
-125
- C2 -
1BEU
1
TRPA_SALTY
A:
[3-262]
-
R
Y
E
N
L
F
A
Q
L
N
D
R
R
E
G
A
F
V
P
F
V
T
L
G
D
P
G
I
E
Q
S
L
K
I
I
D
T
L
I
D
A
G
A
D
A
L
E
L
G
V
P
F
S
D
P
L
A
N
G
P
T
I
Q
N
A
N
L
R
A
F
A
A
G
V
T
P
A
Q
-
C
F
E
M
L
A
L
I
R
E
K
H
P
T
I
P
I
G
L
L
M
Y
A
N
L
V
F
N
N
G
I
D
A
F
Y
A
R
C
E
Q
V
G
V
D
S
V
L
V
A
D
V
P
V
E
E
S
A
P
F
R
Q
A
A
L
R
H
N
I
A
P
I
F
I
C
P
P
N
A
D
D
D
L
L
R
Q
V
A
S
Y
G
R
G
Y
T
Y
---------------
L
P
L
H
H
L
I
E
K
L
K
E
Y
H
A
A
P
A
L
Q
G
F
G
I
S
S
P
E
Q
V
S
A
A
V
R
A
G
A
A
G
A
I
S
G
S
A
I
V
K
I
I
E
K
N
L
A
S
P
K
Q
M
L
A
E
L
R
S
F
V
S
A
M
K
A
50
PsiBlast_CBE
88.73
47%
-120
- C2 -
3NAV
1
TRPA_VIBCH
A:
[6-265]
-
R
Y
Q
A
L
F
Q
R
L
S
A
A
Q
Q
G
A
F
V
P
F
V
T
I
G
D
P
N
P
E
Q
S
L
A
I
M
Q
T
L
I
D
A
G
A
D
A
L
E
L
G
M
P
F
S
D
P
L
A
D
G
P
T
I
Q
G
A
N
L
R
A
L
A
A
K
-
T
T
P
D
I
C
F
E
L
I
A
Q
I
R
A
R
N
P
E
T
P
I
G
L
L
M
Y
A
N
L
V
Y
A
R
G
I
D
D
F
Y
Q
R
C
Q
K
A
G
V
D
S
V
L
I
A
D
V
P
T
N
E
S
Q
P
F
V
A
A
A
E
K
F
G
I
Q
P
I
F
I
A
P
P
T
A
S
D
E
T
L
R
A
V
A
Q
L
G
K
G
Y
T
Y
L
L
S
R
A
--------
A
N
M
P
V
H
A
L
L
E
R
L
Q
Q
F
D
A
P
P
A
L
L
G
F
G
I
S
E
P
A
Q
V
K
Q
A
I
E
A
G
A
A
G
A
I
S
G
S
A
V
V
K
I
I
E
T
H
L
D
N
P
A
K
Q
L
T
E
L
A
N
F
T
Q
A
M
K
K
51
PsiBlast_CBE
88.01
47%
-125
- C2 -
1WQ5
11
TRPA_ECOLI
B:
[3-262]
-
R
Y
E
S
L
F
A
Q
L
K
E
R
K
E
G
A
F
V
P
F
V
T
L
G
D
P
G
I
E
Q
S
L
K
I
I
D
T
L
I
E
A
G
A
D
A
L
E
L
G
I
P
F
S
D
P
L
-----
I
Q
N
A
T
L
R
A
F
A
A
G
V
T
P
A
Q
-
C
F
E
M
L
A
L
I
R
Q
K
H
P
T
I
P
I
G
L
L
M
Y
A
N
L
V
F
N
K
G
I
D
E
F
Y
A
Q
C
E
K
V
G
V
D
S
V
L
V
A
D
V
P
V
E
E
S
A
P
F
R
Q
A
A
L
R
H
N
V
A
P
I
F
I
C
P
P
N
A
D
D
D
L
L
R
Q
I
A
S
Y
G
R
G
Y
T
Y
L
L
S
R
A
G
V
T
--
E
N
R
A
A
L
P
L
N
H
L
V
A
K
L
K
E
Y
N
A
A
P
P
L
Q
G
F
G
I
S
A
P
D
Q
V
K
A
A
I
D
A
G
A
A
G
A
I
S
G
S
A
I
V
K
I
I
E
Q
H
I
N
E
P
E
K
M
L
A
A
L
K
V
F
V
Q
P
M
K
A