@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_1199: (2015-12-21 )
MNQKAYFGEFGGSFVSELLVPALRELEQAFDTCLKDEEFQKEYFRLLKDFVGRPSPLTLCQNIVSNPKVKLYLKREDLIHGGAHKTNQALGQALLAKKMGKTRIIAETGAGQHGVATAIACALLNLKCVIFMGGKDIKRQEMNVFRMRLLGAEVREVNSGSATLKDAVNEALRDWASSYKDTHYLLGTSAGPHPYPTMVKTFQKMIGDEVKSQILEKENRLPDYVIACVGGGSNAIGIFSAFLNDKEVKLIGVEPAGLGLETNKHGATLNKGRVGILHGNKTYLLQDDEGQIAESHSISAGLDYPGVGPEHSYLKEIGRAVYESASDIEALEAFRLLCQKEGIIPALESSHALAYALKLAQKCAQEKIIVVNLSGRGDKDLSTVYNALKGGLK
Atome Classification :
(56 SA)
.........10........20........30........40........50........60........70........80........90........100.-......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270..--.....280.......290.......300.......310.......320.......330.......340.......350.......360..-.-.....370.......380.......390.----
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MNQK
A
Y
F
G
E
F
G
G
S
F
V
S
E
L
L
V
P
A
L
R
E
L
E
Q
A
F
D
T
CLK
D
E
E
F
Q
K
E
Y
F
R
L
L
K
D
FVGRP
S
P
L
T
L
C
Q
N
I
VSNP
K
V
K
L
Y
L
KREDLIHGGAH
K
T
N
Q
A
L
G
Q
A
L
L
A
K
KMGK
T
R
-
I
I
A
ETGAGQ
H
G
V
A
T
A
I
A
C
A
L
LN
L
K
C
V
I
F
MGGKDI
K
R
Q
E
M
N
V
F
R
M
R
L
LGA
E
V
REVNSGS
A
T
L
K
D
A
V
N
E
A
L
R
D
W
A
S
SYKD
T
H
Y
L
L
GTSAGPHPY
P
T
M
V
K
T
F
Q
K
M
I
G
D
E
V
K
S
Q
I
L
E
K
ENRLP
D
Y
V
I
A
C
VGGGS
N
A
I
G
I
F
S
A
FLNDK
E
V
K
L
I
G
VEPAGLGLETNKHGATLNK
G
R
V
--
G
I
L
HGN
K
T
Y
L
L
QDDEGQIAESHSISAGLDYPGVGP
E
H
S
Y
L
K
E
I
G
R
A
V
Y
ESAS
D
I
E
A
L
E
A
F
R
L
L
C
Q
KEGIIPALESS
H
A
L
A
Y
A
L
K
L
A
-
Q
K
C-A-QE
K
I
I
V
V
N
LSGRGDK
D
L
S
T
V
Y
N
A
L
KGGLK----
48
PsiBlast_CBE
93.55
66%
-71
- C2 -
1A5A
2
TRPB_SALTY
B:
[8-391]
-----
Y
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
R
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
A
G
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
S
A
T
L
K
D
A
C
N
E
A
L
R
D
W
S
G
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
G
E
H
G
A
P
L
K
H
G
R
V
--
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
Q
P
-
E
-
K
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
D
I
L
---------
50
PsiBlast_CBE
92.95
66%
-70
- C2 -
1FUY
2
TRPB_SALTY
B:
[7-391]
-----
Y
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
S
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
A
G
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
S
A
T
L
K
D
L
W
N
E
A
L
R
D
W
S
G
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
G
E
H
G
A
P
L
K
H
G
R
V
--
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
Q
P
-
E
-
K
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
D
I
L
K
A
R
------
47
PsiBlast_CBE
92.93
66%
-73
- C2 -
1A5B
2
TRPB_SALTY
B:
[8-391]
-----
Y
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
R
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
A
G
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
S
A
T
L
K
D
A
C
N
E
A
L
R
D
W
S
G
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
G
E
H
G
A
P
L
K
H
G
R
V
--
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
Q
P
-
E
-
K
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
D
I
L
---------
44
PsiBlast_CBE
92.87
66%
-94
- C2 -
2DH6
3
TRPB_ECOLI
A:
[17-392]
--------------
V
P
Q
I
L
M
P
A
L
R
Q
L
E
E
A
F
V
S
A
Q
K
D
P
E
F
Q
A
Q
F
N
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
A
G
T
N
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
T
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
S
A
T
L
K
D
A
C
N
E
A
L
R
D
W
S
G
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
E
R
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
N
E
T
N
V
G
L
I
G
V
E
P
G
----------------------------------------------------
V
G
P
Q
H
A
Y
L
N
S
T
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
L
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
-
R
E
N
-
P
D
K
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
D
I
L
K
A
R
G
E
----
46
PsiBlast_CBE
92.77
66%
-69
- C2 -
1BEU
2
TRPB_SALTY
B:
[8-391]
-----
Y
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
R
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
A
G
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
S
A
T
L
K
D
A
C
N
E
A
L
R
D
W
S
G
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
G
E
H
G
A
P
L
K
H
G
R
V
--
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
Q
P
-
E
-
K
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
D
I
L
---------
51
PsiBlast_CBE
92.57
66%
-71
- C2 -
1QOQ
1
TRPB_SALTY
B:
[7-391]
-----
Y
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
S
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
A
G
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
S
A
T
L
K
D
A
C
N
E
A
L
A
D
W
S
G
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
G
E
H
G
A
P
L
K
H
G
R
V
--
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
Q
P
-
E
-
K
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
D
I
L
K
A
R
G
-----
8
PsiBlast_PDB
92.55
66%
-67
- C2 -
2CLI
3
TRPB_SALTY
B:
[7-391]
-----
Y
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
S
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
A
G
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
S
A
T
L
K
D
A
C
N
E
A
L
R
D
W
S
G
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
G
E
H
G
A
P
L
K
H
G
R
V
--
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
Q
P
-
E
-
K
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
D
I
L
K
A
R
G
E
----
56
PsiBlast_CBE
92.51
65%
-71
- C2 -
2J9Z
2
TRPB_SALTY
B:
[8-392]
-----
Y
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
S
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
A
G
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
V
G
A
G
N
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
S
A
T
L
K
D
A
C
N
E
A
L
R
D
W
S
G
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
G
E
H
G
A
P
L
K
H
G
R
V
--
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
Q
P
-
E
-
K
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
D
I
L
K
A
R
------
2
PsiBlast_PDB
92.51
66%
-65
- C2 -
1K3U
2
TRPB_SALTY
B:
[7-391]
-----
Y
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
S
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
A
G
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
S
A
T
L
K
D
A
C
N
E
A
L
R
D
W
S
G
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
G
E
H
G
A
P
L
K
H
G
R
V
--
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
Q
P
-
E
-
K
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
D
I
L
K
A
R
G
-----
40
PsiBlast_CBE
92.45
66%
-66
- C2 -
2CLH
2
TRPB_SALTY
B:
[7-391]
-----
Y
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
R
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
A
G
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
S
A
T
L
K
D
A
C
N
E
A
L
R
D
W
S
G
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
G
E
H
G
A
P
L
K
H
G
R
V
--
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
Q
P
-
E
-
K
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
D
I
L
K
A
R
G
E
----
6
PsiBlast_PDB
92.45
66%
-66
- C2 -
1TJP
2
TRPB_SALTY
B:
[7-391]
-----
Y
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
S
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
A
G
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
S
A
T
L
K
D
A
C
N
E
A
L
R
D
W
S
G
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
G
E
H
G
A
P
L
K
H
G
R
V
--
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
Q
P
-
E
-
K
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
D
I
L
K
A
R
G
-----
10
PsiBlast_PDB
92.43
66%
-66
- C2 -
2CLL
3
TRPB_SALTY
B:
[7-391]
-----
Y
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
S
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
A
G
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
S
A
T
L
K
D
A
C
N
E
A
L
R
D
W
S
G
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
G
E
H
G
A
P
L
K
H
G
R
V
--
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
Q
P
-
E
-
K
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
D
I
L
K
A
R
G
-----
37
PsiBlast_CBE
92.39
66%
-75
- C2 -
2WSY
2
TRPB_SALTY
B:
[7-387]
-----
Y
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
R
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
A
G
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
----
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
-------
T
L
K
D
A
C
N
E
A
L
R
D
W
S
G
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
G
E
H
G
A
P
L
K
H
G
R
V
--
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
Q
P
-
E
-
K
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
------------
14
PsiBlast_PDB
92.34
66%
-66
- C2 -
1KFC
2
TRPB_SALTY
B:
[8-392]
-----
Y
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
S
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
A
G
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
S
A
T
L
K
D
A
C
N
E
A
L
R
D
W
S
G
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
G
E
H
G
A
P
L
K
H
G
R
V
--
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
Q
P
-
E
-
K
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
D
I
L
K
A
-------
42
PsiBlast_CBE
92.29
66%
-69
- C2 -
2CLE
3
TRPB_SALTY
B:
[7-391]
-----
Y
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
R
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
A
G
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
S
A
T
L
K
D
A
C
N
E
A
L
R
D
W
S
G
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
G
E
H
G
A
P
L
K
H
G
R
V
--
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
Q
P
-
E
-
K
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
D
I
L
K
A
R
G
E
----
41
PsiBlast_CBE
92.19
66%
-66
- C2 -
2CLF
4
TRPB_SALTY
B:
[7-391]
-----
Y
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
R
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
A
G
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
S
A
T
L
K
D
A
C
N
E
A
L
R
D
W
S
G
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
G
E
H
G
A
P
L
K
H
G
R
V
--
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
Q
P
-
E
-
K
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
D
I
L
K
A
R
G
E
----
4
PsiBlast_PDB
92.15
66%
-74
- C2 -
1K7F
1
TRPB_SALTY
B:
[7-391]
-----
Y
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
S
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
A
G
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
S
A
T
L
K
D
A
C
N
E
A
L
R
D
W
S
G
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
--------------
R
V
--
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
Q
P
-
E
-
K
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
D
I
L
K
A
R
G
-----
5
PsiBlast_PDB
92.01
66%
-69
- C2 -
1KFB
1
TRPB_SALTY
B:
[7-391]
-----
Y
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
S
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
A
G
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
S
A
T
L
K
D
A
C
N
E
A
L
R
D
W
S
G
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
G
E
H
G
A
P
L
K
H
G
R
V
--
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
Q
P
-
E
-
K
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
D
I
L
K
A
R
G
-----
1
PsiBlast_PDB
92.00
66%
-66
- C2 -
1QOP
2
TRPB_SALTY
B:
[7-390]
-----
Y
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
S
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
A
G
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
S
A
T
L
K
D
A
C
N
E
A
L
R
D
W
S
G
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
G
E
H
G
A
P
L
K
H
G
R
V
--
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
Q
P
-
E
-
K
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
D
I
L
---------
35
PsiBlast_CBE
91.92
66%
-70
- C2 -
1BKS
2
TRPB_SALTY
B:
[8-392]
-----
Y
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
R
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
A
G
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
S
A
T
L
K
D
A
C
N
E
A
L
R
D
W
S
G
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
G
E
H
G
A
P
L
K
H
G
R
V
--
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
Q
P
-
E
-
K
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
D
I
L
K
A
R
------
26
PsiBlast_CBE
91.90
66%
-65
- C2 -
1K8Y
2
TRPB_SALTY
B:
[7-390]
-----
Y
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
S
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
A
G
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
S
A
T
L
K
D
A
C
N
E
A
L
R
D
W
P
G
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
G
E
H
G
A
P
L
K
H
G
R
V
--
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
Q
P
-
E
-
K
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
D
I
L
---------
22
PsiBlast_CBE
91.89
66%
-68
- C2 -
4HT3
20
TRPB_SALTY
B:
[8-392]
-----
Y
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
S
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
A
G
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
S
A
T
L
K
D
A
C
N
E
A
L
R
D
W
S
G
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
G
E
H
G
A
P
L
K
H
G
R
V
--
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
Q
P
-
E
-
K
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
D
I
L
K
A
R
------
13
PsiBlast_PDB
91.89
66%
-67
- C2 -
1K8X
2
TRPB_SALTY
B:
[8-392]
-----
Y
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
S
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
A
G
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
S
A
T
L
K
D
A
C
N
E
A
L
R
D
W
S
G
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
G
E
H
G
A
P
L
K
H
G
R
V
--
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
Q
P
-
E
-
K
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
D
I
L
K
--------
29
PsiBlast_CBE
91.88
66%
-71
- C2 -
1TTP
3
TRPB_SALTY
B:
[8-391]
-----
Y
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
R
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
A
G
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
S
A
T
L
K
D
A
C
N
E
A
L
R
D
W
S
G
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
G
E
H
G
A
P
L
K
H
G
R
V
--
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
Q
P
-
E
-
K
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
D
I
L
---------
23
PsiBlast_CBE
91.88
66%
-65
- C2 -
1KFE
2
TRPB_SALTY
B:
[7-391]
-----
Y
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
S
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
A
G
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
S
A
T
L
K
D
A
C
N
E
A
L
R
D
W
S
G
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
G
E
H
G
A
P
L
K
H
G
R
V
--
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
Q
P
-
E
-
K
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
D
I
L
K
A
R
G
-----
18
PsiBlast_PDB
91.88
66%
-63
- C2 -
4HPX
13
TRPB_SALTY
B:
[8-392]
-----
Y
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
S
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
A
G
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
S
A
T
L
K
D
A
C
N
E
A
L
R
D
W
S
G
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
G
E
H
G
A
P
L
K
H
G
R
V
--
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
Q
P
-
E
-
K
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
D
I
L
K
A
R
G
E
----
28
PsiBlast_CBE
91.82
66%
-69
- C2 -
1TTQ
2
TRPB_SALTY
B:
[8-391]
-----
Y
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
R
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
A
G
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
S
A
T
L
K
D
A
C
N
E
A
L
R
D
W
S
G
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
G
E
H
G
A
P
L
K
H
G
R
V
--
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
Q
P
-
E
-
K
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
D
I
L
---------
39
PsiBlast_CBE
91.77
66%
-66
- C2 -
2CLM
3
TRPB_SALTY
B:
[7-391]
-----
Y
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
R
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
A
G
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
S
A
T
L
K
D
A
C
N
E
A
L
R
D
W
S
G
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
G
E
H
G
A
P
L
K
H
G
R
V
--
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
Q
P
-
E
-
K
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
D
I
L
K
A
R
------
45
PsiBlast_CBE
91.68
66%
-70
- C2 -
2DH5
4
TRPB_ECOLI
A:
[8-392]
-----
Y
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
R
Q
L
E
E
A
F
V
S
A
Q
K
D
P
E
F
Q
A
Q
F
N
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
A
G
T
N
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
T
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
S
A
T
L
K
D
A
C
N
E
A
L
R
D
W
S
G
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
E
R
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
N
E
T
N
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
G
E
H
G
A
P
L
K
H
G
R
V
--
G
I
Y
F
G
M
K
A
P
M
M
Q
T
E
--
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
T
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
L
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
-
R
E
N
-
P
D
K
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
D
I
L
K
A
R
G
E
----
9
PsiBlast_PDB
91.59
66%
-66
- C2 -
2CLK
2
TRPB_SALTY
B:
[7-390]
-----
Y
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
S
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
A
G
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
S
A
T
L
K
D
A
C
N
E
A
L
R
D
W
S
G
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
G
E
H
G
A
P
L
K
H
G
R
V
--
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
Q
P
-
E
-
K
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
D
I
L
---------
7
PsiBlast_PDB
91.59
66%
-66
- C2 -
1WBJ
2
TRPB_SALTY
B:
[7-390]
-----
Y
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
S
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
A
G
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
S
A
T
L
K
D
A
C
N
E
A
L
R
D
W
S
G
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
G
E
H
G
A
P
L
K
H
G
R
V
--
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
Q
P
-
E
-
K
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
D
I
L
---------
17
PsiBlast_PDB
91.55
66%
-66
- C2 -
2RH9
2
TRPB_SALTY
B:
[8-392]
-----
Y
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
S
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
A
G
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
S
A
T
L
K
D
A
C
N
E
A
L
R
D
W
S
G
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
G
E
H
G
A
P
L
K
H
G
R
V
--
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
Q
P
-
E
-
K
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
D
I
L
K
A
R
G
-----
15
PsiBlast_PDB
91.55
66%
-64
- C2 -
1KFJ
2
TRPB_SALTY
B:
[8-392]
-----
Y
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
S
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
A
G
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
S
A
T
L
K
D
A
C
N
E
A
L
R
D
W
S
G
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
G
E
H
G
A
P
L
K
H
G
R
V
--
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
Q
P
-
E
-
K
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
D
I
L
K
A
R
G
-----
43
PsiBlast_CBE
91.52
66%
-68
- C2 -
1A50
2
TRPB_SALTY
B:
[7-390]
-----
Y
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
R
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
A
G
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
S
A
T
L
K
D
A
C
N
E
A
L
R
D
W
S
G
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
G
E
H
G
A
P
L
K
H
G
R
V
--
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
Q
P
-
E
-
K
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
D
I
L
---------
12
PsiBlast_PDB
91.44
66%
-64
- C2 -
3CEP
4
TRPB_SALTY
B:
[7-391]
-----
Y
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
S
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
A
G
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
S
A
T
L
K
D
A
C
N
E
A
L
R
D
W
S
G
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
G
E
H
G
A
P
L
K
H
G
R
V
--
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
Q
P
-
E
-
K
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
D
I
L
K
A
R
------
25
PsiBlast_CBE
91.34
66%
-68
- C2 -
1K8Z
2
TRPB_SALTY
B:
[7-391]
-----
Y
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
S
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
A
G
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
S
A
T
L
K
D
A
C
N
E
A
L
R
D
W
P
G
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
G
E
H
G
A
P
L
K
H
G
R
V
--
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
Q
P
-
E
-
K
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
D
I
L
K
A
R
G
-----
27
PsiBlast_CBE
91.29
66%
-67
- C2 -
1K7X
2
TRPB_SALTY
B:
[7-390]
-----
Y
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
S
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
A
G
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
S
A
T
L
K
D
A
C
N
E
A
L
R
D
W
P
G
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
G
E
H
G
A
P
L
K
H
G
R
V
--
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
Q
P
-
E
-
K
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
D
I
L
---------
55
PsiBlast_CBE
91.27
66%
-68
- C2 -
1UBS
3
TRPB_SALTY
B:
[8-391]
-----
Y
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
R
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
A
G
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
T
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
S
A
T
L
K
D
A
C
N
E
A
L
R
D
W
S
G
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
G
E
H
G
A
P
L
K
H
G
R
V
--
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
Q
P
-
E
-
K
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
D
I
L
---------
49
PsiBlast_CBE
91.18
66%
-64
- C2 -
2J9Y
2
TRPB_SALTY
B:
[8-392]
-----
Y
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
S
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
A
G
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
N
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
S
A
T
L
K
D
A
C
N
E
A
L
R
D
W
S
G
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
G
E
H
G
A
P
L
K
H
G
R
V
--
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
Q
P
-
E
-
K
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
D
I
L
K
A
R
G
-----
30
PsiBlast_CBE
91.03
66%
-66
- C2 -
1CX9
2
TRPB_SALTY
B:
[8-389]
-----
Y
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
R
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
A
G
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
S
A
T
L
K
D
A
C
N
E
A
L
R
D
W
S
G
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
G
E
H
G
A
P
L
K
H
G
R
V
--
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
Q
P
-
E
-
K
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
D
-----------
19
PsiBlast_PDB
91.02
66%
-63
- C2 -
4HN4
9
TRPB_SALTY
B:
[8-392]
-----
Y
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
S
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
A
G
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
S
A
T
L
K
D
A
C
N
E
A
L
R
D
W
S
G
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
G
E
H
G
A
P
L
K
H
G
R
V
--
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
Q
P
-
E
-
K
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
D
I
L
K
A
R
G
E
----
31
PsiBlast_CBE
90.83
66%
-65
- C2 -
1CW2
2
TRPB_SALTY
B:
[8-389]
-----
Y
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
R
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
A
G
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
S
A
T
L
K
D
A
C
N
E
A
L
R
D
W
S
G
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
G
E
H
G
A
P
L
K
H
G
R
V
--
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
Q
P
-
E
-
K
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
D
-----------
11
PsiBlast_PDB
90.83
66%
-62
- C2 -
2J9X
7
TRPB_SALTY
B:
[7-391]
-----
Y
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
S
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
A
G
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
S
A
T
L
K
D
A
C
N
E
A
L
R
D
W
S
G
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
G
E
H
G
A
P
L
K
H
G
R
V
--
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
Q
P
-
E
-
K
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
D
I
L
K
A
R
G
E
----
16
PsiBlast_PDB
90.82
66%
-66
- C2 -
1KFK
2
TRPB_SALTY
B:
[8-392]
-----
Y
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
S
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
A
G
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
S
A
T
L
K
D
A
C
N
E
A
L
R
D
W
S
G
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
G
E
H
G
A
P
L
K
H
G
R
V
--
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
Q
P
-
E
-
K
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
D
I
L
K
A
-------
20
PsiBlast_PDB
90.80
66%
-63
- C2 -
4HPJ
11
TRPB_SALTY
B:
[8-392]
-----
Y
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
S
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
A
G
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
S
A
T
L
K
D
A
C
N
E
A
L
R
D
W
S
G
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
G
E
H
G
A
P
L
K
H
G
R
V
--
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
Q
P
-
E
-
K
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
D
I
L
K
A
R
G
E
----
3
PsiBlast_PDB
90.65
66%
-65
- C2 -
1K7E
2
TRPB_SALTY
B:
[7-391]
-----
Y
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
S
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
A
G
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
S
A
T
L
K
D
A
C
N
E
A
L
R
D
W
S
G
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
G
E
H
G
A
P
L
K
H
G
R
V
--
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
Q
P
-
E
-
K
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
D
I
L
K
A
R
------
32
PsiBlast_CBE
90.57
66%
-65
- C2 -
1C9D
2
TRPB_SALTY
B:
[8-389]
-----
Y
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
R
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
A
G
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
S
A
T
L
K
D
A
C
N
E
A
L
R
D
W
S
G
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
G
E
H
G
A
P
L
K
H
G
R
V
--
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
Q
P
-
E
-
K
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
D
-----------
36
PsiBlast_CBE
90.51
66%
-65
- C2 -
1A5S
3
TRPB_SALTY
B:
[8-389]
-----
Y
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
R
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
A
G
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
S
A
T
L
K
D
A
C
N
E
A
L
R
D
W
S
G
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
G
E
H
G
A
P
L
K
H
G
R
V
--
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
Q
P
-
E
-
K
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
D
-----------
21
PsiBlast_CBE
90.46
66%
-62
- C2 -
4KKX
15
TRPB_SALTY
B:
[8-392]
-----
Y
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
S
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
A
G
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
S
A
T
L
K
D
A
C
N
E
A
L
R
D
W
S
G
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
G
E
H
G
A
P
L
K
H
G
R
V
--
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
Q
P
-
E
-
K
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
D
I
L
K
A
R
G
E
----
24
PsiBlast_CBE
90.42
66%
-63
- C2 -
3PR2
5
TRPB_SALTY
B:
[6-390]
-----
Y
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
S
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
A
G
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
S
A
T
L
K
D
A
C
N
E
A
L
R
D
W
S
G
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
G
E
H
G
A
P
L
K
H
G
R
V
--
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
Q
P
-
E
-
K
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
D
I
L
K
A
-------
33
PsiBlast_CBE
90.38
66%
-64
- C2 -
1C8V
2
TRPB_SALTY
B:
[8-389]
-----
Y
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
R
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
A
G
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
S
A
T
L
K
D
A
C
N
E
A
L
R
D
W
S
G
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
G
E
H
G
A
P
L
K
H
G
R
V
--
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
Q
P
-
E
-
K
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
D
-----------
53
PsiBlast_CBE
90.31
66%
-63
- C2 -
2TSY
2
TRPB_SALTY
B:
[8-391]
-----
Y
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
R
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
A
G
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
T
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
S
A
T
L
K
D
A
C
N
E
A
L
R
D
W
S
G
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
G
E
H
G
A
P
L
K
H
G
R
V
--
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
Q
P
-
E
-
K
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
D
I
L
---------
34
PsiBlast_CBE
90.07
66%
-63
- C2 -
1C29
2
TRPB_SALTY
B:
[8-389]
-----
Y
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
R
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
A
G
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
S
A
T
L
K
D
A
C
N
E
A
L
R
D
W
S
G
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
G
E
H
G
A
P
L
K
H
G
R
V
--
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
Q
P
-
E
-
K
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
D
-----------
52
PsiBlast_CBE
90.02
66%
-62
- C2 -
2TYS
2
TRPB_SALTY
B:
[8-392]
-----
Y
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
R
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
A
G
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
T
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
S
A
T
L
K
D
A
C
N
E
A
L
R
D
W
S
G
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
G
E
H
G
A
P
L
K
H
G
R
V
--
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
Q
P
-
E
-
K
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
D
I
L
K
A
R
G
E
----
54
PsiBlast_CBE
89.39
66%
-64
* C2 *
2TRS
2
TRPB_SALTY
B:
[8-391]
-----
Y
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
R
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
A
G
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
T
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
S
A
T
L
K
D
A
C
N
E
A
L
R
D
W
S
G
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
G
E
H
G
A
P
L
K
H
G
R
V
--
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
R
E
Q
P
-
E
-
K
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
D
I
L
---------
92
Fugue
88.66
63%
-61
- C2 -
2TYS
2
TRPB_SALTY
B:
[3-397]
T
L
L
N
P
Y
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
R
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
A
G
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
T
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
-
E
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
S
A
T
L
K
D
A
C
N
E
A
L
R
D
W
S
G
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
D
F
I
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
G
E
H
G
A
P
L
K
H
G
--
R
V
G
I
Y
F
G
M
K
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
L
A
H
A
L
K
M
M
-
R
E
Q
P
E
-
K
E
Q
L
L
V
V
N
L
S
G
-
R
G
--
D
K
D
I
F
T
V
H
D
I
L
K
A
R
GEI