@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_1251: (2015-12-22 )
MHDFLKAFKDAFPHTISIFLGYLLMGMTFGMLLAQQGYDYKVALFMSLFIYAGAIQFVAITLLSAQASLMNVVIVSLLVNARQTCYALSMLDRFKNTKWRLPYLAHALTDETFALLNLYAPKKGVNETDFMFSISLLNHSYWIFGSLVGSLVGSHFSFDTQGMEFVMTAIFIVLFMEQYKRNTNHKNAWLGIAIAVVCLALFGTEYFLLIALVLMVLALILFRKQLEC
Atome Classification :
(17 SA)
---------------------------........----.10....----------------------...-.20........30......-----..-----40....------....50....---------....60........70------.........80---......--..90........------100......--.--110..-.....120.......130...-----....140.......150--.......160.......170...----------------.-...180----........----190------......------...200---------.......----210..--------.....220......--------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
---------------------------M
H
D
F
L
K
A
F
----
K
D
AFP
H
T
----------------------
I
S
I
-
F
L
G
Y
L
L
M
G
M
T
F
G
M
L
L
A
QQG-----Y
D
-----
Y
K
V
A
L
F
------
M
S
L
F
I
Y
A
G
A
I
---------
Q
F
V
A
I
T
L
L
S
A
Q
A
S
L
M
-------
N
V
V
I
V
S
L
L
V
N
A
---
R
Q
T
C
Y
A
--
L
S
M
L
D
R
FKNTKW------R
L
P
Y
L
A
H
A
L--
T
--
D
E
T
F
A
-
L
L
N
LYAPKKGVNET
D
F
M
F
S
I
S
-----LLNH
S
Y
W
I
F
G
S
L
V
G
S
L
V
--
G
SHFSFDT
Q
G
M
E
F
V
M
T
A
I
F
I
V
L
F
----------------
M
-
E
Q
Y
KR-----NTNHK
N
A
W
----
L
--------
G
I
A
I
A
V
------
V
C
L
A
L
F---------G
T
E
Y
F
L
L
----
I
A
L
V
L
--------
M
V
L
A
L
I
L
F
R
K
QLEC--------------------------------------------------------------------------------------------------------------------------------------------------------
16
Fugue
86.49
17%
-174
- C3 -
4F0D
1
PAR16_HUMAN
A:
[2-271]
--------------------------------
M
G
W
----
A
A
A
R
E
A
A
----------------------
G
R
D
-
M
L
A
A
D
L
R
C
S
L
F
A
S
A
L
Q
S
Y
K
-----
R
D
-----
S
V
L
R
P
F
------
P
A
S
Y
A
R
G
D
C
K
---------
D
F
E
A
L
L
A
D
A
S
K
L
P
N
L
-------
K
E
L
L
Q
S
S
G
D
N
H
---
K
R
A
W
D
L
--
V
S
W
I
--
L
S
S
K
V
L
------
T
I
H
S
A
G
K
A
E
--
F
--
E
K
I
Q
K
-
L
T
G
--
A
P
H
T
P
V
P
A
P
D
F
L
F
E
I
E
-----
Y
F
D
P
A
N
A
K
F
Y
E
T
K
G
E
R
---
D
L
I
Y
A
F
H
G
S
R
L
E
N
F
H
S
I
I
H
N
G
L
H
CHKTSLFG
E
G
T
Y
L
T
SD
L
-
S
L
A
L
I
-----
Y
S
P
H
G
H
G
W
QHSL
L
--------
G
P
I
L
S
C
------
V
A
V
C
E
V
IDH------
P
D
K
Y
F
V
V
----
T
N
N
Q
L
--------
L
R
V
K
Y
L
L
V
Y
S
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------
13
Fugue
68.05
11%
-178
* C2 *
1OMO
2
ALADH_ARCFU
A:
[1-320]
-----------M
E
T
L
I
L
T
Q
E
E
V
E
S
L
I
S
M
D
E
A
M
N
A
V
----
E
E
A
F
R
L
Y
A
L
GK
A
Q
M
P
P
KVYLEFEK
G
D
L
R
A
M
P
A
-
H
L
M
G
Y
A
G
L
K
W
V
N
S
H
P
G
N
P
D
KGLPT
V
M
-----
A
L
M
I
L
N
S
PETGF
P
L
A
V
M
D
A
T
Y
T
---------
T
S
L
R
T
G
A
A
G
G
I
A
A
K
Y
LARKNSS
V
F
G
F
I
G
C
G
T
Q
A
---
Y
F
Q
L
E
A
--
L
R
R
V
F
D
I
G
E
V
K
A
Y
D
VR
E
K
A
A
K
K
F
V
S
Y
C
--
E
--
D
R
G
I
S
-
A
S
V
--
Q
P
A
E
E
A
S
R
C
D
V
L
V
T
T
T
PSRKP
V
V
K
A
E
W
V
E
E
G
T
H
I
N
A
I
G
--
A
D
G
P
G
K
Q
E
L
D
V
E
I
L
K
K
A
K
I
V
V
D
D
----------------
L
-
E
Q
A
K
H
GGEI
N
V
A
V
S
K
G
V
I
----
G
--------
V
E
D
V
H
A
------
T
I
G
E
V
I
A
GLKDGRES
D
E
E
I
T
I
F
D
S
TG
L
A
I
Q
D
--------
V
A
V
A
K
V
V
Y
E
N
A
L
S
K
N
V
G
S
K
I
KFF-----------------------------------------------------------------------------------------------------------------------------------------------
17
Fugue
65.88
16%
-159
- C3 -
1HD8
-
DACA_ECOLI
A:
[3-262]
--------------------------------
L
N
I
----
K
T
M
I
P
G
V
----------------------
P
Q
I
D
A
E
S
Y
I
L
I
D
Y
N
S
G
K
V
L
A
E
Q
N
-----
A
D
VRRDP
A
S
L
T
K
M
------
M
T
S
Y
V
I
G
Q
A
M
K
A
GKFKET
D
L
V
T
I
G
----------------------
N
L
K
P
G
M
---
Q
V
P
V
S
Q
--
L
I
R
D
I
N
L
Q
S
G
N
D
------
A
C
V
A
M
A
D
F
A
AG
S
--
Q
D
A
F
V
G
L
M
N
S
Y
V
N
A
L
G
L
K
N
T
H
F
Q
T
V
H
G
-----
L
D
A
D
G
Q
Y
S
S
A
R
D
M
A
L
I
G
--
Q
A
L
I
R
D
V
P
N
E
Y
S
I
Y
K
E
K
E
F
T
F
N
------------------G----
I
-----
R
Q
L
N
R
N
G
L
----
L
WDNSLNVD
G
I
K
T
G
H
T
DKA
G
Y
N
L
V
A
S
A
---------
T
E
G
Q
M
R
L
----
I
S
A
V
M
GGRTFKGR
E
A
E
S
K
K
L
L
T
W
G
F
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------
14
Fugue
60.72
13%
-137
- C2 -
3O7Q
1
FUCP_ECOLI
A:
[22-435]
RSYI
I
P
F
A
L
L
C
S
L
F
F
L
W
A
V
A
N
N
L
N
D
I
L
L
P
Q
F
Q
Q
A
F
TLTN
F
Q
A
G
L
I
Q
----------------------
S
A
F
-
Y
F
G
Y
F
I
I
P
I
P
A
G
I
L
M
K
K
L
S
-----
Y
K
-----
A
G
I
I
T
G
------
L
F
L
Y
A
L
G
A
A
L
---------
F
W
P
A
A
E
I
M
N
Y
T
L
F
L
V
-------
G
L
F
I
I
A
A
G
L
G
C
---
L
E
T
A
A
N
P
F
V
T
V
L
G
P
E
S
S
G
H
F
------
R
L
-
N
L
A
Q
T
F
--
N
--
S
F
G
A
I
-
I
A
V
V
F
G
Q
S
L
I
L
S
N
V
P
H
Q
S
Q
D
V
-----
L
D
K
M
S
P
E
Q
L
S
A
Y
K
H
S
L
V
---
L
S
V
Q
T
P
Y
M
I
I
V
A
I
V
L
L
V
A
L
L
I
M
----------------
L
-
T
K
F
P
A
L
QS--
D
N
H
S
D
A
K
Q
----
G
--------
S
F
S
A
S
L
------
S
R
L
A
R
I
---------
R
H
W
R
W
A
V
----
L
A
Q
F
C
--------
Y
V
G
A
Q
T
A
C
W
S
Y
L
I
R
Y
A
V
E
E
IPGMT
A
G
F
A
A
N
Y
L
T
G
T
M
V
C
F
F
I
G
R
F
T
G
T
W
L
I
S
R
F
A
P
H
K
V
L
A
A
Y
A
L
I
A
M
A
L
C
L
I
S
A
F
A
GG
H
V
G
L
I
A
L
T
L
CSAFMSI
Q
Y
P
T
I
F
S
L
G
I
KNLGQD
T
K
Y
G
S
S
F
I
V
M
TI
I
G
G
G
I
V
T
P
V
M
G
F
V
S
D
A
A
GNIPTAE
L
I
P
A
L
C
F
A
V
I
F
I
F
A
R
F
RSQT
12
Fugue
58.42
11%
-137
- C3 -
3LGI
1
DEGS_ECOLI
B:
[4-231]
------------LNPLS
T
P
Q
F
D
S
T
D
E
T
P
A
S
Y
N
L
A
V
----
R
R
A
A
P
A
V
----------------------
V
N
V
-
Y
N
R
G
L
N
T
N
S
H
N
Q
L
E
I
R
T
L
G
-----
S
G
-----
V
I
M
D
Q
R
------
G
Y
I
I
T
N
K
H
V
I
---------
N
D
A
D
Q
I
I
V
A
L
Q
D
G
---------
R
V
F
E
A
L
L
V
G
S
D
---
S
L
T
D
L
A
--
V
L
K
I
N
A
T
G
G
L
P
T
------
I
P
I
N
A
R
R
V
P
--
H
IG
D
V
V
L
A
-
I
G
N
P
Y
----
N
L
G
Q
T
I
T
Q
G
I
I
S
-----
A
T
G
R
I
G
L
N
P
T
G
R
Q
N
F
L
Q
T
D
A
S
I
N
H
G
N
S
G
G
A
L
V
N
S
L
G
E
L
M
G
I
N
----------------
T
-
L
S
F
D
K
-----
S
N
D
G
E
T
P
-----
E
--------
G
I
G
F
A
I
------
P
-------------------------
F
Q
L
A
T
--------
K
I
M
D
K
L
I
R
D
G
R
V
I
R
--------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
42.49
28%
-12
* C5 *
4L92
3
?
A:
[198-273]
-------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
V
Q
S
I
P
I
N
G
VAN
R
P
V
S
S
T
--
A
S
Q
L
T
N
Y
K
--
V
W
------
R
N
P
Y
L
C
S
Q
D
--
P
--
R
D
K
F
A
-
P
D
N
L
V
I
E
E
D
G
I
Y
R
I
D
I
S
G
S
I
N
-----
I
A
N
Y
T
F
P
A
S
G
N
S
W
R
V
G
G
--
R
Y
F
Q
I
V
C
A
R
N
S
S
A
N
N
L
A
E
F
G
A
E
Q
----------------
H
-
L
P
P
S
G
-----
V
W
T
R
R
V
L
V
----
G
--------
E
Y
T
A
G
M
------
T
E
Q
A
F
S
---------
S
V
A
T
I
S
L
----
F
K
G
D
N
--------
F
F
L
Q
F
E
T
G
T
N
T
S
R
D
--------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
42.45
28%
-6
- C5 -
4RGG
1
?
A:
[198-273]
-------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
V
Q
S
I
P
I
N
G
VAN
R
P
V
S
S
T
--
A
S
Q
L
T
N
Y
K
--
V
W
------
R
N
P
Y
L
C
S
Q
D
--
P
--
R
D
K
F
A
-
P
D
N
L
V
I
E
E
D
G
I
Y
R
I
D
I
S
G
S
I
N
-----
I
A
N
Y
T
F
P
A
S
G
N
S
W
R
V
G
G
--
R
Y
F
Q
I
V
C
A
R
N
S
S
A
N
N
L
A
E
F
G
A
E
Q
----------------
H
-
L
P
P
S
G
-----
V
W
T
R
R
V
L
V
----
G
--------
E
Y
T
A
G
M
------
T
E
Q
A
F
S
---------
S
V
A
T
I
S
L
----
F
K
G
D
N
--------
F
F
L
Q
F
E
T
G
T
N
T
S
R
D
--------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
41.83
28%
-9
- C5 -
4RGA
2
?
A:
[198-273]
-------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
V
Q
S
I
P
I
N
G
VAN
R
P
V
S
S
T
--
A
S
Q
L
T
N
Y
K
--
V
W
------
R
N
P
Y
L
C
S
Q
D
--
P
--
R
D
K
F
A
-
P
D
N
L
V
I
E
E
D
G
I
Y
R
I
D
I
S
G
S
I
N
-----
I
A
N
Y
T
F
P
A
S
G
N
S
W
R
V
G
G
--
R
Y
F
Q
I
V
C
A
R
N
S
S
A
N
N
L
A
E
F
G
A
E
Q
----------------
H
-
L
P
P
S
G
-----
V
W
T
R
R
V
L
V
----
G
--------
E
Y
T
A
G
M
------
T
E
Q
A
F
S
---------
S
V
A
T
I
S
L
----
F
K
G
D
N
--------
F
F
L
Q
F
E
T
G
T
N
T
S
R
D
--------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
41.82
28%
-11
- C5 -
4L99
1
?
A:
[198-273]
-------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
V
Q
S
I
P
I
N
G
VAN
R
P
V
S
S
T
--
A
S
Q
L
T
N
Y
K
--
V
W
------
R
N
P
Y
L
C
S
Q
D
--
P
--
R
D
K
F
A
-
P
D
N
L
V
I
E
E
D
G
I
Y
R
I
D
I
S
G
S
I
N
-----
I
A
N
Y
T
F
P
A
S
G
N
S
W
R
V
G
G
--
R
Y
F
Q
I
V
C
A
R
N
S
S
A
N
N
L
A
E
F
G
A
E
Q
----------------
H
-
L
P
P
S
G
-----
V
W
T
R
R
V
L
V
----
G
--------
E
Y
T
A
G
M
------
T
E
Q
A
F
S
---------
S
V
A
T
I
S
L
----
F
K
G
D
N
--------
F
F
L
Q
F
E
T
G
T
N
T
S
R
D
--------------------------------------------------------------------------------------------------------------------------------------------------------
9
HHSearch
41.31
17%
-60
- C4 -
2LOR
-
TM141_HUMAN
A:
[59-82]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
L
Q
W
S
L
L
----
V
A
V
V
A
--------
G
S
V
V
S
Y
G
V
T
R
V
E
S
E
--------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
41.24
28%
-10
- C5 -
4L97
1
?
A:
[198-273]
-------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
V
Q
S
I
P
I
N
G
VAN
R
P
V
S
S
T
--
A
S
Q
L
T
N
Y
K
--
V
W
------
R
N
P
Y
L
C
S
Q
D
--
P
--
R
D
K
F
A
-
P
D
N
L
V
I
E
E
D
G
I
Y
R
I
D
I
S
G
S
I
N
-----
I
A
N
Y
T
F
P
A
S
G
N
S
W
R
V
G
G
--
R
Y
F
Q
I
V
C
A
R
N
S
S
A
N
N
L
A
E
F
G
A
E
Q
----------------
H
-
L
P
P
S
G
-----
V
W
T
R
R
V
L
V
----
G
--------
E
Y
T
A
G
M
------
T
E
Q
A
F
S
---------
S
V
A
T
I
S
L
----
F
K
G
D
N
--------
F
F
L
Q
F
E
T
G
T
N
T
S
R
D
--------------------------------------------------------------------------------------------------------------------------------------------------------
20
Fugue
30.88
20%
16
* C3 *
2CPG
1
COPG_STRAG
A:
[1-43]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
K
R
L
T
I
T
L
--
S
--
E
S
V
L
E
-
N
L
E
K
M
A
R
E
M
G
L
S
K
S
A
-
M
I
S
V
A
-----
L
E
N
Y
K
K
G
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
Fugue
29.67
21%
20
- C4 -
2KV5
-
?
A:
[1-33]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
D
L
M
S
L
V
I
A
P
I
F
V
G
L
V
----------------
L
-
E
M
I
S
R
-----
V
L
D
E
E
D
D
S
----
R
--------
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
Fugue
27.99
37%
131
* C4 *
4P6K
-
?
A:
[1-25]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
K
E
I
A
H
A
L
--
F
--
S
A
L
F
A
-
L
S
E
L
Y
I
A
V
R
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
HHSearch
21.28
13%
869
- C1 -
1AFO
-
GLPA_HUMAN
A:
[93-100]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
G
I
R
R
L
I
K
---------------------------------------------------------------------------------------------------------------------------------------------------------
10
HHSearch
17.73
25%
233
- C4 -
3WU2
-
PSBJ_THEVL
J:
[9-24]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
L
W
I
V
A
T
V
A
G
M
G
V
--
I
V
I
V
G
L
F
F
Y
G
A
Y
A
G
L
G
S
S
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
HHSearch
15.55
33%
360
- C4 -
3DCG
-
VIF_HV1N5
E:
[6-17]
--------------------------------------------------------------------------------------------------------------------------
G
S
L
---------
Q
Y
L
A
L
A
A
L
I
K
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------