@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_1264: (2015-12-22 )
MLAKMSFMQNVKNIQEVDVNHKRVLIRVDFNVPLDENLNITDDTRIRESLPTIQFCIDNKAKDIILVSHLGRPKGVEEKLSLKPFLKRLERLLNHEVVFSQNIAQLKQALNENAPTRIFLLENIRFLKGEEENDENLAKDLASLCDVFVNDAFGTSHRKHASTYGTAKFAPIKVSGFLLKKEIDSFYQAFNHPLRPLLLIVGGAKVSSKLTLLKNILDLIDKLIIAGAMSNTFLKALGYDVQDSSVEDALINDALELLQSAKEKKVKVYLPIDAVTTDDILNPKHIKISPVQDIEPKHKIADIGPASLKLFSEVIESAPTILWNGPLGVHEKQEFARGTTFLAHKIANTYAFSLIGGGDTIDAINRAGEKDNMSFISTGGGASLELLEGKILPCFEVLDKRH
Atome Classification :
(51 SA)
.........10........20........30........40........50........60........70...--.--..--..80........90........100.--.--.--....110.....--------..120....---------------...130----..--------------....-...140--------.........150.......160.......--170--.......180.......190.......200.......210.....--..--220.......230.....-..240......-------.250.......260.......270.......280.....-.-.-----.290.......300........310.......320.......330.......340.....---..---350---..---......360.......370.......380.......390.......400
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
ML
A
K
M
S
F
M
Q
N
V
K
N
I
Q
E
VDVNH
K
R
V
L
I
R
V
DFNVPLDENLNITD
D
T
R
I
R
E
SLP
T
I
Q
F
C
IDNKA
K
D
I
I
L
V
SHLGRPK--
G
--
V
E
--
E
KL
S
L
K
P
F
L
K
R
L
E
R
L
LN
H
E
V
V
F
S
Q
N
I
--
A
--
Q
--
L
K
Q
A
LNENA
P
T
R
--------
I
F
L
LEN
I
R
F---------------LKGE------EE--------------
N
D
E
N
-
L
A
K
D
----------
L
A
S
L
C
D
V
F
V
NDAFGTSHRKHASTYGT
A
K
F
--
A
P
I
--
K
V
S
G
F
L
L
K
K
E
I
D
S
F
Y
Q
A
F
NHPL
R
P
L
L
L
I
VGG
A
K
V
S
S
K
L
T
L
L
K
N
I
L
--
D
L
--
I
D
K
L
I
I
A
G
A
M
S
N
T
F
L
K
A
L-GYDVQDSS
V
E
D
-------
A
L
I
N
D
A
L
E
L
L
Q
SAKEK
K
V
K
V
Y
L
P
IDAVTTDDI-LNPK
H
I
-
K
-I-----SPVQDIEPKHKIA-DI
G
P
A
S
L
K
L
F
S
E
V
I
E
SA
P
T
I
L
WNGPLG
V
H
E
K
Q
E
F
ARG
T
T
F
L
A
H
K
I
A---N
T
---
Y
-
A
---
F
S
---
L
IGGG
D
T
I
D
A
I
N
RAGEKDN
M
S
F
I
STGGG
A
S
L
E
LLEGKI
L
P
C
F
E
V
L
DKRH
1
PsiBlast_PDB
95.08
48%
-98
- C7 -
3Q3V
5
PGK_CAMJE
A:
[6-399]
---------
D
I
I
S
I
K
D
I
D
L
A
K
K
K
V
F
I
R
C
D
F
N
V
P
Q
D
D
F
L
N
I
T
D
D
R
R
I
R
S
A
I
P
T
I
R
Y
C
L
D
N
G
C
S
-
V
I
L
A
S
H
L
G
R
P
K
--
E
--
I
S
--
S
K
Y
S
L
E
P
V
A
K
R
L
A
R
L
L
D
K
E
I
V
M
A
K
D
V
------------
I
G
E
D
A
K
T
K
A
M
N
LKAG
E
I
L
L
L
E
N
L
R
F
---------------
E
K
G
E
------
T
K
--------------
N
D
E
N
-
L
A
K
E
----------
L
A
S
M
V
Q
V
Y
I
N
D
A
F
G
V
C
H
R
A
H
S
S
V
E
A
I
T
K
F
F
D
E
K
H
--
K
G
A
G
F
L
L
Q
K
E
I
D
F
A
S
N
L
I
K
H
P
A
R
P
F
V
A
V
V
G
G
S
K
V
S
G
K
L
Q
A
L
T
N
L
L
--
P
K
--
V
D
K
L
I
I
G
G
G
M
A
F
T
F
L
K
A
L
-
G
Y
D
I
G
N
S
L
L
E
E
-------
E
L
L
E
E
A
N
K
I
L
T
K
G
K
N
L
G
V
K
I
Y
L
P
V
D
V
V
A
A
P
A
C
-
S
Q
D
V
P
M
-
K
-
F
-----
V
P
A
Q
E
I
P
N
G
W
M
G
L
-
D
I
G
P
A
S
V
R
L
F
K
E
V
I
S
D
A
Q
T
I
W
W
N
G
P
M
G
V
F
E
I
D
K
F
S
K
G
S
I
K
M
S
H
Y
I
S
---
E
G
---
H
-
A
---
T
S
---
V
V
G
G
G
D
T
A
D
V
V
A
R
A
G
D
A
D
E
M
T
F
I
S
T
G
G
G
A
S
L
E
L
I
E
G
K
E
L
P
G
V
K
A
L
R
S
--
73
HHSearch
94.83
49%
-96
* C7 *
3Q3V
5
PGK_CAMJE
A:
[6-399]
---------
D
I
I
S
I
K
D
I
D
L
A
K
K
K
V
F
I
R
C
D
F
N
V
P
Q
D
D
F
L
N
I
T
D
D
R
R
I
R
S
A
I
P
T
I
R
Y
C
L
D
N
G
C
S
-
V
I
L
A
S
H
L
G
R
P
K
--
E
--
I
S
--
S
K
Y
S
L
E
P
V
A
K
R
L
A
R
L
L
D
K
E
I
V
M
A
K
D
V
--
I
--
G
E
D
A
K
T
K
A
M
N
L
K
A
G
E
--------
I
L
L
L
E
N
L
R
F
---------------
E
K
G
E
------
T
K
--------------
N
D
E
N
-
L
A
K
E
----------
L
A
S
M
V
Q
V
Y
I
N
D
A
F
G
V
C
H
R
A
H
S
S
V
E
A
I
T
K
F
--
F
D
E
KH
K
G
A
G
F
L
L
Q
K
E
I
D
F
A
S
N
L
I
K
H
P
A
R
P
F
V
A
V
V
G
G
S
K
V
S
G
K
L
Q
A
L
T
N
L
L
--
P
K
--
V
D
K
L
I
I
G
G
G
M
A
F
T
F
L
K
A
L
-
G
Y
D
I
G
N
S
L
L
E
E
-------
E
L
L
E
E
A
N
K
I
L
T
K
G
K
N
L
G
V
K
I
Y
L
P
V
D
V
V
A
A
P
A
C
-
S
Q
D
V
P
M
-
K
-
F
-----
V
P
A
Q
E
I
P
N
G
W
M
G
L
-
D
I
G
P
A
S
V
R
L
F
K
E
V
I
S
D
A
Q
T
I
W
W
N
G
P
M
G
V
F
E
I
D
K
F
S
K
G
S
I
K
M
S
H
Y
I
S
---
E
G
---
H
-
A
---
T
S
---
V
V
G
G
G
D
T
A
D
V
V
A
R
A
G
D
A
D
E
M
T
F
I
S
T
G
G
G
A
S
L
E
L
I
E
G
K
E
L
P
G
V
K
A
L
R
S
--
74
HHSearch
94.27
46%
-100
- C7 -
1PHP
2
PGK_GEOSE
A:
[1-394]
--------
M
N
K
K
T
I
R
D
V
D
V
R
G
K
R
V
F
C
R
V
D
F
N
V
P
M
E
-
Q
G
A
I
T
D
D
T
R
I
R
A
A
L
P
T
I
R
Y
L
I
E
H
G
A
K
-
V
I
L
A
S
H
L
G
R
P
K
--
G
--
K
V
V-
E
E
L
R
L
D
A
V
A
K
R
L
G
E
L
L
E
R
P
V
A
K
T
N
E
A
--
V
--
G
D
E
V
K
A
A
V
D
R
L
N
E
G
D
--------
V
L
L
L
E
N
V
R
F
---------------
Y
P
G
E
------
E
K
--------------
N
D
P
E
-
L
A
K
A
----------
F
A
E
L
A
D
L
Y
V
N
D
A
F
G
A
A
H
R
A
H
A
S
T
E
G
I
A
H
Y
--
L
P
A
---
V
A
G
F
L
M
E
K
E
L
E
V
L
G
K
A
L
S
N
P
D
R
P
F
T
A
I
I
G
G
A
K
V
K
D
K
I
G
V
I
D
N
L
L
--
E
K
--
V
D
N
L
I
I
G
G
G
L
A
Y
T
F
V
K
A
L
-
G
H
D
V
G
K
S
L
L
E
E
-------
D
K
I
E
L
A
K
S
F
M
E
K
A
K
E
K
G
V
R
F
Y
M
P
V
D
V
V
V
A
D
R
F
-
A
N
D
A
N
T
-
K
-
V
-----
V
P
I
D
A
I
P
A
D
W
S
A
L
-
D
I
G
P
K
T
R
E
L
Y
R
D
V
I
R
E
S
K
L
V
V
W
N
G
P
M
G
V
F
E
M
D
A
F
A
H
G
T
K
A
I
A
E
A
L
A
---
E
A
L--
D
-
T
---
Y
S
---
V
I
G
G
G
D
S
A
A
A
V
E
K
F
G
L
A
D
K
M
D
H
I
S
T
G
G
G
A
S
L
E
F
M
E
G
K
Q
L
P
G
V
V
A
L
E
D
K
-
2
PsiBlast_PDB
93.94
45%
-98
- C7 -
1PHP
2
PGK_GEOSE
A:
[2-394]
---------
N
K
K
T
I
R
D
V
D
V
R
G
K
R
V
F
C
R
V
D
F
N
V
P
M
E
Q
G
A
-
I
T
D
D
T
R
I
R
A
A
L
P
T
I
R
Y
L
I
E
H
G
A
K
-
V
I
L
A
S
H
L
G
R
P
K
--
G
K-
V
V
--
E
E
L
R
L
D
A
V
A
K
R
L
G
E
L
L
E
R
P
V
A
K
T
N
E
A
--
V
G
D
E
--
V
K
A
A
V
D
R
L
N
E
G
D
--------
V
L
L
L
E
N
V
R
F
---------------
Y
P
G
E
------
E
K
--------------
N
D
P
E
-
L
A
K
A
----------
F
A
E
L
A
D
L
Y
V
N
D
A
F
G
A
A
H
R
A
H
A
S
T
E
G
I
A
H
Y
--
L
P
---
A
V
A
G
F
L
M
E
K
E
L
E
V
L
G
K
A
L
S
N
P
D
R
P
F
T
A
I
I
G
G
A
K
V
K
D
K
I
G
V
I
D
N
L
L
--
E
K
--
V
D
N
L
I
I
G
G
G
L
A
Y
T
F
V
K
A
L
-
G
H
D
V
G
K
S
L
L
E
E
-------
D
K
I
E
L
A
K
S
F
M
E
K
A
K
E
K
G
V
R
F
Y
M
P
V
D
V
V
V
A
D
R
F
-
A
N
D
A
N
T
-
K
-
V
-----
V
P
I
D
A
I
P
A
D
W
S
A
L
-
D
I
G
P
K
T
R
E
L
Y
R
D
V
I
R
E
S
K
L
V
V
W
N
G
P
M
G
V
F
E
M
D
A
F
A
H
G
T
K
A
I
A
E
A
L
A
---
E
A
---
L
D
T
---
Y
S
---
V
I
G
G
G
D
S
A
A
A
V
E
K
F
G
L
A
D
K
M
D
H
I
S
T
G
G
G
A
S
L
E
F
M
E
G
K
Q
L
P
G
V
V
A
L
E
D
K
-
38
PsiBlast_CBE
93.25
39%
-108
- C7 -
2ZGV
1
PGK1_HUMAN
A:
[6-417]
-------
L
S
N
K
L
T
L
D
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
N
-
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
K
S
V
V
L
M
S
H
L
G
R
P
D
--
G
--
V
P
MP
D
K
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
K
D
C
--
V
G
P
E
--
V
E
K
A
C
A
N
P
A
A
G
S
--------
V
I
L
L
E
N
L
R
F
HVEEEG
K
G
K
D
ASGN
K
V
K
A
E
------
P
A
--------------
K
I
E
A
-
F
R
A
S
----------
L
S
K
L
G
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
----
L
P
Q
--
K
A
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
--
D
K
--
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
N
M
E
I
G
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
S
K
A
E
K
N
G
V
K
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
T
G
-
Q
-
A
-----
T
V
A
S
G
I
P
A
G
W
M
G
L
-
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
V
---
K
A
---
T
-
S
R
GC
I
T
---
I
I
G
G
------------
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
I
-
49
PsiBlast_CBE
93.21
39%
-107
- C7 -
4O3F
2
PGK1_MOUSE
A:
[3-414]
-------
L
S
N
K
L
T
L
D
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
N
-
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
K
S
V
V
L
M
S
H
L
G
R
P
D
--
G
--
V
P
MP
D
K
Y
S
L
E
P
V
A
A
E
L
K
S
L
L
G
K
D
V
L
F
L
K
D
C
--
V
G
P
E
--
V
E
N
A
C
A
N
P
A
A
G
T
--------
V
I
L
L
E
N
L
R
F
HVEEEG
K
G
K
D
ASG
N
K
V
K
A
E
------
P
A
--------------
K
I
D
A
-
F
R
A
S
----------
L
S
K
L
G
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
----
L
P
Q
--
K
A
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
--
D
K
--
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
N
M
E
I
G
T
S
L
Y
D
E
-------
E
G
A
K
I
V
K
D
L
M
S
K
A
E
K
N
G
V
K
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
T
G
-
Q
-
A
-----
T
V
A
S
G
I
P
A
G
W
M
G
L
-
D
C
G
T
E
S
S
K
K
Y
A
E
A
V
G
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
S
L
M
D
E
V
V
---
K
A
---
T
-
S
R
GC
I
T
---
I
I
G
G
G
D
T
A
T
--------
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
V
-
39
PsiBlast_CBE
93.16
39%
-98
- C7 -
2X15
3
PGK1_HUMAN
A:
[2-413]
-------
L
S
N
K
L
T
L
D
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
N
-
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
K
S
V
V
L
M
S
H
L
G
R
P
D
--
G
--
V
P
MP
D
K
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
K
D
C
--
V
G
P
E
--
V
E
K
A
C
A
N
P
A
A
G
S
--------
V
I
L
L
E
N
L
R
F
HVEEEGKGK-------
K
A
E
------
P
A
--------------
K
I
E
A
-
F
R
A
S
----------
L
S
K
L
G
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
----
L
P
Q
--
K
A
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
--
D
K
--
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
N
M
E
I
G
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
S
K
A
E
K
N
G
V
K
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
T
G
-
Q
-
A
-----
T
V
A
S
G
I
P
A
G
W
M
G
L
-
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
V
---
K
A
---
T
-
S
R
GC
I
T
---
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
I
-
31
PsiBlast_CBE
92.71
39%
-109
- C7 -
3C3C
3
PGK1_HUMAN
A:
[6-417]
-------
L
S
N
K
L
T
L
D
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
N
-
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
K
S
V
V
L
M
S
H
L
G
R
P
D
--
G
--
V
P
MP
D
K
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
K
D
C
--
V
G
P
E
--
V
E
K
A
C
A
N
P
A
A
G
S
--------
V
I
L
L
E
N
L
R
F
HVEEEG
K
G
K
D
ASG
N
K
V
K
A
E
------
P
A
--------------
K
I
E
A
-
F
R
A
S
----------
L
S
K
L
G
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
----
L
P
Q
--
K
A
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
--
D
K
--
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
N
M
E
I
G
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
S
K
A
E
K
N
G
V
K
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
T
G
-
Q
-
A
-----
T
V
A
S
G
I
P
A
G
W
M
G
L
-
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
V
---
K
A
---
T
-
S
R
G
C
I
T
---
I
I
G
G
-------------
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
I
-
33
PsiBlast_CBE
92.63
39%
-108
- C7 -
3C3B
1
PGK1_HUMAN
A:
[6-417]
-------
L
S
N
K
L
T
L
D
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
N
-
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
K
S
V
V
L
M
S
H
L
G
R
P
D
--
G
--
V
P
MP
D
K
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
K
D
C
--
V
G
P
E
--
V
E
K
A
C
A
N
P
A
A
G
S
--------
V
I
L
L
E
N
L
R
F
HVEEEG
K
G
K
D
ASG
N
K
V
K
A
E
------
P
A
--------------
K
I
E
A
-
F
R
A
S
----------
L
S
K
L
G
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
----
L
P
Q
--
K
A
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
--
D
K
--
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
N
M
E
I
G
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
S
K
A
E
K
N
G
V
K
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
T
G
-
Q
-
A
-----
T
V
A
S
G
I
P
A
G
W
M
G
L
-
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
V
---
K
A
---
T
-
S
R
G
C
I
T
---
I
I
G
G
-------------
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
I
-
18
PsiBlast_PDB
92.57
39%
-100
- C7 -
2XE8
2
PGK1_HUMAN
A:
[5-414]
---------
N
K
L
T
L
D
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
N
-
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
K
S
V
V
L
M
S
H
L
G
R
P
D
--
G
--
V
P
MP
D
K
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
K
D
C
--
V
G
P
E
--
V
E
K
A
C
A
N
P
A
A
G
S
--------
V
I
L
L
E
N
L
R
F
HVEEEG
K
G
K
D
ASG
N
K
V
K
A
E
------
P
A
--------------
K
I
E
A
-
F
R
A
S
----------
L
S
K
L
G
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
----
L
P
Q
--
K
A
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
--
D
K
--
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
N
M
E
I
G
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
S
K
A
E
K
N
G
V
K
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
T
G
-
Q
-
A
-----
T
V
A
S
G
I
P
A
G
W
M
G
L
-
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
V
---
K
A
---
T
-
S
R
GC
I
T
---
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
I
-
16
PsiBlast_PDB
92.55
39%
-101
- C7 -
2XE6
1
PGK1_HUMAN
A:
[5-414]
---------
N
K
L
T
L
D
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
N
-
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
K
S
V
V
L
M
S
H
L
G
R
P
D
--
G
--
V
P
MP
D
K
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
K
D
C
--
V
G
P
E
--
V
E
K
A
C
A
N
P
A
A
G
S
--------
V
I
L
L
E
N
L
R
F
HVEEEG
K
G
K
D
ASG
N
K
V
K
A
E
------
P
A
--------------
K
I
E
A
-
F
R
A
S
----------
L
S
K
L
G
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
----
L
P
Q
--
K
A
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
--
D
K
--
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
N
M
E
I
G
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
S
K
A
E
K
N
G
V
K
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
T
G
-
Q
-
A
-----
T
V
A
S
G
I
P
A
G
W
M
G
L
-
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
V
---
K
A
---
T
-
S
R
GC
I
T
---
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
I
-
45
PsiBlast_CBE
92.22
39%
-96
- C7 -
2WZD
5
PGK1_HUMAN
A:
[3-414]
-------
L
S
N
K
L
T
L
D
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
N
-
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
K
S
V
V
L
M
S
H
L
G
R
P
D
--
G
--
V
P
MP
D
K
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
K
D
C
--
V
G
P
E
--
V
E
K
A
C
A
N
P
A
A
G
S
--------
V
I
L
L
E
N
L
R
F
HVEEEGKG----------
E
------
P
A
--------------
K
I
E
A
-
F
R
A
S
----------
L
S
K
L
G
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
----
L
P
Q
--
K
A
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
A
I
Q
L
I
N
N
M
L
--
D
K
--
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
N
M
E
I
G
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
S
K
A
E
K
N
G
V
K
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
T
G
-
Q
-
A
-----
T
V
A
S
G
I
P
A
G
W
M
G
L
-
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
V
---
K
A
---
T
-
S
R
GC
I
T
---
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
I
-
43
PsiBlast_CBE
92.17
39%
-99
- C7 -
4O33
2
PGK1_HUMAN
A:
[3-414]
-------
L
S
N
K
L
T
L
D
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
N
-
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
K
S
V
V
L
M
S
H
L
G
R
P
D
--
G
--
V
P
MP
D
K
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
K
D
C
--
V
G
P
E
--
V
E
K
A
C
A
N
P
A
A
G
S
--------
V
I
L
L
E
N
L
R
F
HVEEEG
K
G
K
D
ASG
N
K
V
K
A
E
------
P
A
--------------
K
I
E
A
-
F
R
A
S
----------
L
S
K
L
G
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
----
L
P
Q
--
K
A
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
--
D
K
--
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
N
M
E
I
G
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
S
K
A
E
K
N
G
V
K
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
T
G
-
Q
-
A
-----
T
V
A
S
G
I
P
A
G
W
M
G
L
-
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
V
---
K
A
---
T
-
S
R
GC
I
T
---
T
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
I
-
77
HHSearch
92.14
46%
-97
- C7 -
1VPE
3
PGKT_THEMA
A:
[2-396]
----------
K
M
T
I
R
D
V
D
L
K
G
K
R
V
I
M
R
V
D
F
N
V
P
V
K
-
D
G
V
V
Q
D
D
T
R
I
R
A
A
L
P
T
I
K
Y
A
L
E
Q
G
A
K
-
V
I
L
L
S
H
L
G
R
P
K
--
G
--
E
P
S-
P
E
F
S
L
A
P
V
A
K
R
L
S
E
L
L
G
K
E
V
K
F
V
P
A
V
--
V
--
G
D
E
V
K
K
A
V
E
E
L
K
E
G
E
--------
V
L
L
L
E
N
T
R
F
---------------
H
P
G
E
------
T
K
--------------
N
D
P
E
-
L
A
K
F
----------
W
A
S
L
A
D
I
H
V
N
D
A
F
G
T
A
H
R
A
H
A
S
N
V
G
I
A
Q
F
--
I
P
S
---
V
A
G
F
L
M
E
K
E
I
K
F
L
S
K
V
T
Y
N
P
E
K
P
Y
V
V
V
L
G
G
A
K
V
S
D
K
I
G
V
I
T
N
L
M
--
E
K
--
A
D
R
I
L
I
G
G
A
M
M
F
T
F
L
K
A
L
-
G
K
E
V
G
S
S
R
V
E
E
-------
D
K
I
D
L
A
K
E
L
V
E
K
A
K
E
K
G
V
E
I
V
L
P
V
D
A
V
I
A
Q
K
I
-
E
P
G
V
E
K
-
K
-
V
V
----
R
I
D
D
G
I
P
E
G
W
M
G
L
-
D
I
G
P
E
T
I
E
L
F
K
Q
K
L
S
D
A
K
T
V
V
W
N
G
P
M
G
V
F
E
I
D
D
F
A
E
G
T
K
Q
V
A
L
A
I
A
---
A
L
T
E
K
G
-
A
---
I
T
---
V
V
G
G
G
D
S
A
A
A
V
N
K
F
G
L
E
D
K
F
S
H
V
S
T
G
G
G
A
S
L
E
F
L
E
G
K
E
L
P
G
I
A
S
M
R
I
K
K
20
PsiBlast_PDB
92.10
39%
-97
- C7 -
3ZOZ
5
PGK1_HUMAN
A:
[3-414]
-------
L
S
N
K
L
T
L
D
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
N
-
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
K
S
V
V
L
M
S
H
L
G
R
P
D
--
G
--
V
P
MP
D
K
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
K
D
C
--
V
GP
E
--
V
E
K
A
C
A
N
P
A
A
G
S
--------
V
I
L
L
E
N
L
R
F
HVEEEGKG----------
E
------
P
A
--------------
K
I
E
A
-
F
R
A
S
----------
L
S
K
L
G
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
----
L
P
Q
--
K
A
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
--
D
K
--
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
N
M
E
I
G
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
S
K
A
E
K
N
G
V
K
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
T
G
-
Q
-
A
-----
T
V
A
S
G
I
P
A
G
W
M
G
L
-
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
V
---
K
A
---
T
-
S
R
GC
I
T
---
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
I
-
37
PsiBlast_CBE
92.07
39%
-108
- C7 -
3C39
1
PGK1_HUMAN
A:
[6-417]
-------
L
S
N
K
L
T
L
D
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
N
-
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
K
S
V
V
L
M
S
H
L
G
R
P
D
--
G
--
V
P
MP
D
K
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
K
D
C
--
V
G
P
E
--
V
E
K
A
C
A
N
P
A
A
G
S
--------
V
I
L
L
E
N
L
R
F
HVEEEGKGK-------
K
A
E
------
P
A
--------------
K
I
E
A
-
F
R
A
S
----------
L
S
K
L
G
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
----
L
P
Q
--
K
A
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
--
D
K
--
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
N
M
E
I
G
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
S
K
A
E
K
N
G
V
K
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
T
G
-
Q
-
A
-----
T
V
A
S
G
I
P
A
G
W
M
G
L
-
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
V
---
K
A
---
T
-
S
R
GC
I
T
---
I
I
G
G
-------------
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
I
-
35
PsiBlast_CBE
91.75
39%
-102
- C7 -
3C3A
1
PGK1_HUMAN
A:
[6-417]
-------
L
S
N
K
L
T
L
D
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
N
-
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
K
S
V
V
L
M
S
H
L
G
R
P
D
--
G
--
V
P
MP
D
K
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
K
D
C
--
V
G
P
E
--
V
E
K
A
C
A
N
P
A
A
G
S
--------
V
I
L
L
E
N
L
R
F
HVEEEG
K
G
K
D
ASGN
K
V
K
A
E
------
P
A
--------------
K
I
E
A
-
F
R
A
S
----------
L
S
K
L
G
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
----
L
P
Q
--
K
A
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
--
D
K
--
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
N
M
E
I
G
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
S
K
A
E
K
N
G
V
K
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
T
G
-
Q
-
A
-----
T
V
A
S
G
I
P
A
G
W
M
G
L
-
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
V
---
K
A
---
T
-
S
R
G
C
I
T
---
I
I
G
G
---------
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
I
-
17
PsiBlast_PDB
91.67
39%
-96
- C7 -
2XE7
2
PGK1_HUMAN
A:
[5-414]
---------
N
K
L
T
L
D
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
N
-
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
K
S
V
V
L
M
S
H
L
G
R
P
D
--
G
--
V
P
MP
D
K
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
K
D
C
--
V
G
P
E
--
V
E
K
A
C
A
N
P
A
A
G
S
--------
V
I
L
L
E
N
L
R
F
HVEEEG
K
G
K
D
ASG
N
K
V
K
A
E
------
P
A
--------------
K
I
E
A
-
F
R
A
S
----------
L
S
K
L
G
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
----
L
P
Q
--
K
A
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
--
D
K
--
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
N
M
E
I
G
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
S
K
A
E
K
N
G
V
K
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
T
G
-
Q
-
A
-----
T
V
A
S
G
I
P
A
G
W
M
G
L
-
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
V
---
K
A
---
T
-
S
R
GC
I
T
---
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
I
-
44
PsiBlast_CBE
91.53
39%
-96
- C7 -
2X14
3
PGK1_HUMAN
A:
[2-413]
-------
L
S
N
K
L
T
L
D
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
N
-
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
K
S
V
V
L
M
S
H
L
G
R
P
D
--
G
--
V
P
MP
D
K
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
K
D
C
--
V
G
P
E
--
V
E
K
A
C
A
N
P
A
A
G
S
--------
V
I
L
L
E
N
L
R
F
HVEEEGKG----------
E
------
P
A
--------------
K
I
E
A
-
F
R
A
S
----------
L
S
K
L
G
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
----
L
P
Q
--
K
A
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
A
I
Q
L
I
N
N
M
L
--
D
K
--
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
N
M
E
I
G
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
S
K
A
E
K
N
G
V
K
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
T
G
-
Q
-
A
-----
T
V
A
S
G
I
P
A
G
W
M
G
L
-
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
V
---
K
A
---
T
-
S
R
GC
I
T
---
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
I
-
29
PsiBlast_CBE
91.47
39%
-95
- C7 -
4AXX
5
PGK1_HUMAN
A:
[3-414]
-------
L
S
N
K
L
T
L
D
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
N
-
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
K
S
V
V
L
M
S
H
L
G
R
P
D
--
G
--
V
P
MP
D
K
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
K
D
C
--
V
G
P
E
--
V
E
K
A
C
A
N
P
A
A
G
S
--------
V
I
L
L
E
N
L
R
F
HVEEEGKGK--------
A
E
------
P
A
--------------
K
I
E
A
-
F
R
A
S
----------
L
S
K
L
G
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
----
L
P
Q
--
K
A
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
--
D
K
--
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
N
M
E
I
G
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
S
K
A
E
K
N
G
V
K
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
T
G
-
Q
-
A
-----
T
V
A
S
G
I
P
A
G
W
M
G
L
-
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
V
---
K
A
---
T
-
S
R
GC
I
T
---
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
I
-
40
PsiBlast_CBE
91.42
39%
-96
- C7 -
2X13
3
PGK1_HUMAN
A:
[2-413]
-------
L
S
N
K
L
T
L
D
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
N
-
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
K
S
V
V
L
M
S
H
L
G
R
P
D
--
G
--
V
P
MP
D
K
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
K
D
C
--
V
G
P
E
--
V
E
K
A
C
A
N
P
A
A
G
S
--------
V
I
L
L
E
N
L
R
F
HVEEEGKGK-------
K
A
E
------
P
A
--------------
K
I
E
A
-
F
R
A
S
----------
L
S
K
L
G
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
----
L
P
Q
--
K
A
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
--
D
K
--
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
N
M
E
I
G
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
S
K
A
E
K
N
G
V
K
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
T
G
-
Q
-
A
-----
T
V
A
S
G
I
P
A
G
W
M
G
L
-
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
V
---
K
A
---
T
-
S
R
GC
I
T
---
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
I
-
42
PsiBlast_CBE
91.38
39%
-97
- C7 -
2WZB
5
PGK1_HUMAN
A:
[2-413]
-------
L
S
N
K
L
T
L
D
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
N
-
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
K
S
V
V
L
M
S
H
L
G
R
P
D
--
G
--
V
P
MP
D
K
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
K
D
C
--
V
G
P
E
--
V
E
K
A
C
A
N
P
A
A
G
S
--------
V
I
L
L
E
N
L
R
F
HVEEEGKG----------
E
------
P
A
--------------
K
I
E
A
-
F
R
A
S
----------
L
S
K
L
G
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
----
L
P
Q
--
K
A
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
--
D
K
--
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
N
M
E
I
G
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
S
K
A
E
K
N
G
V
K
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
T
G
-
Q
-
A
-----
T
V
A
S
G
I
P
A
G
W
M
G
L
-
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
V
---
K
A
---
T
-
S
R
GC
I
T
---
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
I
-
41
PsiBlast_CBE
91.00
39%
-97
- C7 -
2WZC
5
PGK1_HUMAN
A:
[2-413]
-------
L
S
N
K
L
T
L
D
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
N
-
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
K
S
V
V
L
M
S
H
L
G
R
P
D
--
G
--
V
P
MP
D
K
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
K
D
C
--
V
G
P
E
--
V
E
K
A
C
A
N
P
A
A
G
S
--------
V
I
L
L
E
N
L
R
F
HVEEEGKG----------
E
------
P
A
--------------
K
I
E
A
-
F
R
A
S
----------
L
S
K
L
G
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
----
L
P
Q
--
K
A
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
--
D
K
--
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
N
M
E
I
G
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
S
K
A
E
K
N
G
V
K
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
T
G
-
Q
-
A
-----
T
V
A
S
G
I
P
A
G
W
M
G
L
-
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
V
---
K
A
---
T
-
S
R
GC
I
T
---
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
I
-
76
HHSearch
90.96
42%
-91
- C7 -
2WZB
5
PGK1_HUMAN
A:
[2-415]
-------
L
S
N
K
L
T
L
D
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
K
S
V
V
L
M
S
H
L
G
R
P
D
--
G
--
V
P
MP
D
K
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
K
D
C
--
V
--
G
P
E
V
E
K
A
C
A
N
P
A
A
G
S
--------
V
I
L
L
E
N
L
R
F
---------------
H
V
E
E
------
E
G
KGE
P
A
---------
K
I
E
A
-
F
R
A
S
----------
L
S
K
L
G
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
----
L
P
Q
--
K
A
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
--
D
K
--
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
N
M
E
I
G
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
S
K
A
E
K
N
G
V
K
I
T
L
P
V
D
F
V
T
A
D
K
F
-
D
E
N
A
K
T
G
Q
-
A
-----
T
V
A
S
G
I
P
A
G
W
M
G
L
-
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
V
---
K
A
T
S
R
G
-
C
---
I
T
---
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
I
-
19
PsiBlast_PDB
90.91
39%
-96
- C7 -
2YBE
5
PGK1_HUMAN
A:
[3-414]
-------
L
S
N
K
L
T
L
D
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
N
-
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
K
S
V
V
L
M
S
H
L
G
R
P
D
--
G
--
V
P
MP
D
K
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
K
D
C
--
V
G
P
E
--
V
E
K
A
C
A
N
P
A
A
G
S
--------
V
I
L
L
E
N
L
R
F
HVEEEGKGKK-----
V
K
A
E
------
P
A
--------------
K
I
E
A
-
F
R
A
S
----------
L
S
K
L
G
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
----
L
P
Q
--
K
A
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
--
D
K
--
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
N
M
E
I
G
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
S
K
A
E
K
N
G
V
K
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
T
G
-
Q
-
A
-----
T
V
A
S
G
I
P
A
G
W
M
G
L
-
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
V
---
K
A
---
T
-
S
R
G
C
I
T
---
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
I
-
36
PsiBlast_CBE
90.82
39%
-108
- C7 -
3C39
1
PGK1_HUMAN
B:
[6-417]
-------
L
S
N
K
L
T
L
D
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
N
-
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
K
S
V
V
L
M
S
H
L
G
R
P
D
--
G
--
V
P
MP
D
K
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
K
D
----------
E
K
A
C
A
N
P
A
A
G
S
--------
V
I
L
L
E
N
L
R
F
HVEEEG
K
G
K
D
ASG
N
K
V
K
A
E
------
P
A
--------------
K
I
E
A
-
F
R
A
S
----------
L
S
K
L
G
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
----
L
P
Q
--
K
A
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
--
D
K
--
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
N
M
E
I
G
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
S
K
A
E
K
N
G
V
K
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
T
G
-
Q
-
A
-----
T
V
A
S
G
I
P
A
G
W
M
G
L
-
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
V
---
K
A
---
T
-
S
R
G
C
I
T
---
I
I
G
G
-------------
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
I
-
32
PsiBlast_CBE
90.78
39%
-108
- C7 -
3C3B
2
PGK1_HUMAN
B:
[6-417]
-------
L
S
N
K
L
T
L
D
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
N
-
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
K
S
V
V
L
M
S
H
L
G
R
P
D
--
G
--
V
P
MP
D
K
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
K
D
C
--
V
------
E
K
A
C
A
N
P
A
A
G
S
--------
V
I
L
L
E
N
L
R
F
HVEEEG
K
G
K
D
ASG
N
K
V
K
A
E
------
P
A
--------------
K
I
E
A
-
F
R
A
S
----------
L
S
K
L
G
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
----
L
P
Q
--
K
A
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
--
D
K
--
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
N
M
E
I
G
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
S
K
A
E
K
N
G
V
K
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
T
G
-
Q
-
A
-----
T
V
A
S
G
I
P
A
G
W
M
G
L
-
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
V
---
K
A
---
T
-
S
R
G
C
I
T
---
I
I
G
G
-------------
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
I
-
81
HHSearch
90.70
42%
-96
- C7 -
1QPG
2
PGK_YEAST
A:
[3-414]
--------
S
S
K
L
S
V
Q
D
L
D
L
K
D
K
R
V
F
I
R
V
D
F
N
V
P
L
D
-
G
K
K
I
T
S
N
Q
R
I
V
A
A
L
P
T
I
K
Y
V
L
E
H
H
P
R
Y
V
V
L
A
S
H
L
G
Q
P
N
--
G
--
E
R
N-
E
K
Y
S
L
A
P
V
A
K
E
L
Q
S
L
L
G
K
D
V
T
F
L
N
D
C
--
V
--
G
P
E
V
E
A
A
V
K
A
S
A
P
G
S
--------
V
I
L
L
E
N
L
R
Y
---------------
H
I
E
E
------
E
G
S
R
K
V
DGQKVKAS
K
E
D
V
Q
K
-
F
R
H
E
----------
L
S
S
L
A
D
V
Y
I
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
F
D
----
L
P
Q
--
R
A
A
G
F
L
L
E
K
E
L
K
Y
F
G
K
A
L
E
N
P
T
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
D
N
L
L
--
D
K
--
V
D
S
I
I
I
G
G
G
M
A
F
T
F
K
K
V
L
E
N
T
E
I
G
D
S
I
F
D
K
-------
A
G
A
E
I
V
P
K
L
M
E
K
A
K
A
K
G
V
E
V
V
L
P
V
D
F
I
I
A
D
A
F
-
S
A
D
A
N
T
K
T
-
V
-----
T
D
K
E
G
I
P
A
G
W
Q
G
L
-
D
N
G
P
E
S
R
K
L
F
A
A
T
V
A
K
A
K
T
I
V
W
N
G
P
P
G
V
F
E
F
E
K
F
A
A
G
T
K
A
L
L
D
E
V
V
---
K
S
S
A
A
G
-
N
---
T
V
---
I
I
G
G
G
D
T
A
T
V
A
K
K
Y
G
V
T
D
K
I
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
E
L
P
G
V
A
F
L
S
E
K
K
3
PsiBlast_PDB
90.54
46%
-97
- C7 -
1VPE
3
PGKT_THEMA
A:
[4-388]
------------
T
I
R
D
V
D
L
K
G
K
R
V
I
M
R
V
D
F
N
V
P
V
K
D
G
V
-
V
Q
D
D
T
R
I
R
A
A
L
P
T
I
K
Y
A
L
E
Q
G
A
K
-
V
I
L
L
S
H
L
G
R
P
K
--
G
E-
P
S
--
P
E
F
S
L
A
P
V
A
K
R
L
S
E
L
L
G
K
E
V
K
F
V
P
A
V
--
V
G
D
E
--
V
K
K
A
V
E
E
L
K
E
G
E
--------
V
L
L
L
E
N
T
R
F
---------------
H
P
G
E
------
T
K
--------------
N
D
P
E
-
L
A
K
F
----------
W
A
S
L
A
D
I
H
V
N
D
A
F
G
T
A
H
R
A
H
A
S
N
V
G
I
A
Q
F
--
I
P
---
S
V
A
G
F
L
M
E
K
E
I
K
F
L
S
K
V
T
Y
N
P
E
K
P
Y
V
V
V
L
G
G
A
K
V
S
D
K
I
G
V
I
T
N
L
M
--
E
K
--
A
D
R
I
L
I
G
G
A
M
M
F
T
F
L
K
A
L
-
G
K
E
V
G
S
S
R
V
E
E
-------
D
K
I
D
L
A
K
E
L
V
E
K
A
K
E
K
G
V
E
I
V
L
P
V
D
A
V
I
A
Q
K
I
-
E
P
G
V
E
K
-
K
-
V
-----
V
R
I
D
D
G
I
P
E
G
W
M
G
L
D
I
G
P
E
T
I
E
L
F
K
Q
K
L
S
D
A
K
T
V
V
W
N
G
P
M
G
V
F
E
I
D
D
F
A
E
G
T
K
Q
V
A
L
A
I
A
A
L
T
E
K
---
G
-
A
---
I
T
---
V
V
G
G
G
D
S
A
A
A
V
N
K
F
G
L
E
D
K
F
S
H
V
S
T
G
G
G
A
S
L
E
F
L
E
G
K
E
L
P
G
I
A
S
M
R
I
K
K
34
PsiBlast_CBE
90.38
39%
-107
- C7 -
3C3A
3
PGK1_HUMAN
B:
[6-417]
-------
L
S
N
K
L
T
L
D
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
N
-
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
K
S
V
V
L
M
S
H
L
G
R
P
D
--
G
--
V
P
MP
D
K
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
K
D
C
--
V
-------
K
A
C
A
N
P
A
A
G
S
--------
V
I
L
L
E
N
L
R
F
HVEEEG
K
G
K
D
AS
G
N
K
V
K
A
E
------
P
A
--------------
K
I
E
A
-
F
R
A
S
----------
L
S
K
L
G
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
----
L
P
Q
--
K
A
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
--
D
K
--
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
N
M
E
I
G
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
S
K
A
E
K
N
G
V
K
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
T
G
-
Q
-
A
-----
T
V
A
S
G
I
P
A
G
W
M
G
L
-
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
V
---
K
A
---
T
-
S
R
GC
I
T
---
I
I
G
G
------------
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
I
-
28
PsiBlast_CBE
90.38
40%
-96
- C7 -
2Y3I
5
PGK1_HUMAN
D:
[3-414]
-------
M
S
N
K
L
T
L
D
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
N
-
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
K
S
V
V
L
M
S
H
L
G
R
P
D
--
G
--
V
P
MP
D
K
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
K
D
C
--
V
GP
E
--
V
E
K
A
C
A
N
P
A
A
G
S
--------
V
I
L
L
E
N
L
R
F
HVEEEGKGKDASGNK
V
K
A
E
------
P
A
--------------
K
I
E
A
-
F
R
A
S
----------
L
S
K
L
G
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
----
L
P
Q
--
K
A
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
--
D
K
--
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
N
M
E
I
G
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
S
K
A
E
K
N
G
V
K
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
T
G
-
Q
-
A
-----
T
V
A
S
G
I
P
A
G
W
M
G
L
-
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
V
---
K
A
---
T
-
S
RGC
I
T
---
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
--
30
PsiBlast_CBE
90.30
39%
-106
- C7 -
3C3C
1
PGK1_HUMAN
B:
[6-417]
-------
L
S
N
K
L
T
L
D
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
N
-
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
K
S
V
V
L
M
S
H
L
G
R
P
D
--
G
--
V
P
MP
D
K
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
K
D
C
--
V
------
E
K
A
C
A
N
P
A
A
G
S
--------
V
I
L
L
E
N
L
R
F
HVEEEG
K
G
K
D
AS
G
N
K
V
K
A
E
------
P
A
--------------
K
I
E
A
-
F
R
A
S
----------
L
S
K
L
G
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
----
L
P
Q
--
K
A
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
--
D
K
--
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
N
M
E
I
G
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
S
K
A
E
K
N
G
V
K
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
T
G
-
Q
-
A
-----
T
V
A
S
G
I
P
A
G
W
M
G
L
-
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
V
---
K
A
---
T
-
S
R
G
C
I
T
---
I
I
G
G
-------------
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
I
-
15
PsiBlast_PDB
90.30
40%
-97
- C7 -
2Y3I
5
PGK1_HUMAN
A:
[3-414]
-------
M
S
N
K
L
T
L
D
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
N
-
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
K
S
V
V
L
M
S
H
L
G
R
P
D
--
G
--
V
P
MP
D
K
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
K
D
C
--
V
G
P
E
--
V
E
K
A
C
A
N
P
A
A
G
S
--------
V
I
L
L
E
N
L
R
F
HVEEEG
K
G
K
D
ASGN
K
V
K
A
E
------
P
A
--------------
K
I
E
A
-
F
R
A
S
----------
L
S
K
L
G
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
----
L
P
Q
--
K
A
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
--
D
K
--
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
N
M
E
I
G
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
S
K
A
E
K
N
G
V
K
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
T
G
-
Q
-
A
-----
T
V
A
S
G
I
P
A
G
W
M
G
L
-
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
V
---
K
A
---
T
-
S
R
G
C
I
T
---
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
--
51
PsiBlast_CBE
89.91
38%
-100
- C7 -
1KF0
3
PGK1_PIG
A:
[2-413]
-------
L
S
N
K
L
T
L
D
K
L
N
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
N
-
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
D
G
A
K
S
V
V
L
M
S
H
L
G
R
P
D
--
G
SP
M
P
--
D
K
Y
S
L
Q
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
K
D
C
--
V
G
P
E
--
V
E
K
A
C
A
D
P
A
A
G
S
--------
V
I
L
L
E
N
L
R
F
HVEEEG
K
G
K
D
ASG
N
K
V
K
A
E
------
P
A
--------------
K
I
K
T
-
F
R
A
S
----------
L
S
K
L
G
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
----
L
P
K
--
K
A
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
--
D
K
--
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
N
M
E
I
G
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
N
L
M
S
K
A
E
K
N
G
V
K
I
T
L
P
V
D
F
V
T
A
D
K
F
-
D
E
H
A
K
T
-
G
-
Q
-----
A
T
V
A
S
G
I
P
A
G
W
M
G
L
D
C
G
P
E
S
S
K
K
Y
S
E
A
V
A
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
Q
G
T
K
A
L
M
D
E
V
V
---
K
A
---
T
-
S
R
G
C
I
T
---
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
V
-
47
PsiBlast_CBE
89.86
39%
-99
- C7 -
1VJC
1
PGK1_PIG
A:
[2-413]
-------
L
S
N
K
L
T
L
D
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
N
-
Q
I
T
N
N
Q
R
I
K
A
A
I
P
S
I
K
F
C
L
D
N
G
A
K
S
V
V
L
M
S
H
L
G
R
P
D
--
G
--
I
P
MP
D
K
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
K
D
C
--
V
G
P
E
--
V
E
K
A
C
A
D
P
A
A
G
S
--------
V
I
L
L
E
N
L
R
F
HVEEE----------
G
K
G
K
------
D
A
--------------
S
G
S
K
-
V
K
A
D
P
A
K
I
E
A
F
R
A
S
L
S
K
L
G
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
----
L
P
K
--
K
A
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
--
D
K
--
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
N
M
E
I
G
T
S
L
F
D
E
-------
E
G
S
K
I
V
K
D
L
M
S
K
A
E
K
N
G
V
K
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
T
G
-
Q
-
A
-----
T
V
A
S
G
I
P
A
G
W
M
G
L
-
D
C
G
P
E
S
S
K
K
Y
S
E
A
V
A
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
Q
G
T
K
A
L
M
D
E
V
V
---
K
A
---
T
-
S
R
G
C
I
T
---
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
V
-
14
PsiBlast_PDB
89.67
40%
-100
- C7 -
2PAA
1
PGK2_MOUSE
A:
[8-413]
-------------
L
D
K
V
D
L
K
G
K
R
V
I
M
R
V
D
F
N
V
P
M
K
N
N
-
Q
I
T
N
N
Q
R
I
K
A
A
I
P
S
I
K
H
C
L
D
N
G
A
K
S
V
V
L
M
S
H
L
G
R
P
D
--
G
--
I
P
MP
D
K
Y
S
L
E
P
V
A
D
E
L
K
S
L
L
N
K
D
V
I
F
L
K
D
C
--
V
G
P
E
--
V
E
Q
A
C
A
N
P
D
N
G
S
--------
I
I
L
L
E
N
L
R
F
HVEEE----------
G
K
G
K
------
D
S
--------------
S
G
K
K
-
I
S
A
D
P
A
K
V
E
A
F
R
A
S
L
S
K
L
G
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
----
L
P
Q
--
K
A
S
G
F
L
M
K
K
E
L
D
Y
F
S
K
A
L
E
K
P
E
R
P
F
L
A
I
L
G
G
A
K
V
K
D
K
I
Q
L
I
K
N
M
L
--
D
K
--
V
N
F
M
I
I
G
G
G
M
A
Y
T
F
L
K
E
L
K
N
M
Q
I
G
A
S
L
F
D
E
-------
E
G
A
T
I
V
K
E
I
M
E
K
A
E
K
N
G
V
K
I
V
F
P
V
D
F
V
T
G
D
K
F
-
D
E
N
A
K
V
-
G
-
Q
-----
A
T
I
E
S
G
I
P
S
G
W
M
G
L
D
C
G
P
E
S
I
K
I
N
A
Q
I
V
A
Q
A
K
L
I
V
W
N
G
P
I
G
V
F
E
W
D
A
F
A
K
G
T
K
A
L
M
D
E
V
V
---
K
A
---
T
-
S
N
G
C
V
T
---
I
I
G
G
G
D
T
A
T
C
C
A
K
W
G
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
I
L
P
G
V
E
A
L
S
N
M
-
50
PsiBlast_CBE
89.62
39%
-102
- C7 -
1QPG
2
PGK_YEAST
A:
[7-414]
------------
S
V
Q
D
L
D
L
K
D
K
R
V
F
I
R
V
D
F
N
V
P
L
D
G
K
-
K
I
T
S
N
Q
R
I
V
A
A
L
P
T
I
K
Y
V
L
E
H
H
P
R
Y
V
V
L
A
S
H
L
G
Q
P
N
--
G
--
E
R
N-
E
K
Y
S
L
A
P
V
A
K
E
L
Q
S
L
L
G
K
D
V
T
F
L
N
D
C
--
V
G
P
E
--
V
E
A
A
V
K
A
S
A
P
G
S
--------
V
I
L
L
E
N
L
R
Y
HIEEEG
S
R
K
V
DGQK-
V
K
A
S
------
K
E
--------------
D
V
Q
K
-
F
R
H
E
----------
L
S
S
L
A
D
V
Y
I
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
F
D
----
L
P
Q
--
R
A
A
G
F
L
L
E
K
E
L
K
Y
F
G
K
A
L
E
N
P
T
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
D
N
L
L
--
D
K
--
V
D
S
I
I
I
G
G
G
M
A
F
T
F
K
K
V
L
E
N
T
E
I
G
D
S
I
F
D
K
-------
A
G
A
E
I
V
P
K
L
M
E
K
A
K
A
K
G
V
E
V
V
L
P
V
D
F
I
I
A
D
A
F
-
S
A
D
A
N
T
-
K
T
V
-----
T
D
K
E
G
I
P
A
G
W
Q
G
L
-
D
N
G
P
E
S
R
K
L
F
A
A
T
V
A
K
A
K
T
I
V
W
N
G
P
P
G
V
F
E
F
E
K
F
A
A
G
T
K
A
L
L
D
E
V
V
---
K
S
---
S
-
A
---
A
G
N
T
V
I
I
G
G
G
D
T
A
T
V
A
K
K
Y
G
V
T
D
K
I
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
E
L
P
G
V
A
F
L
S
E
K
K
46
PsiBlast_CBE
89.55
39%
-98
- C7 -
1VJD
2
PGK1_PIG
A:
[2-413]
-------
L
S
N
K
L
T
L
D
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
N
-
Q
I
T
N
N
Q
R
I
K
A
A
I
P
S
I
K
F
C
L
D
N
G
A
K
S
V
V
L
M
S
H
L
G
R
P
D
--
G
--
I
P
MP
D
K
Y
S
L
E
P
V
A
V
E
L
K
S
L
L
G
K
D
V
L
F
L
K
D
C
--
V
G
P
E
--
V
E
K
A
C
A
D
P
A
A
G
S
--------
V
I
L
L
E
N
L
R
F
HVEEE----------
G
K
G
K
------
D
A
--------------
S
G
S
K
-
V
K
A
D
P
A
K
I
E
A
F
R
A
S
L
S
K
L
G
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
----
L
P
K
--
K
A
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
--
D
K
--
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
N
M
E
I
G
T
S
L
F
D
E
-------
E
G
S
K
I
V
K
D
L
M
S
K
A
E
K
N
G
V
K
I
T
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
T
G
-
Q
-
A
-----
T
V
A
S
G
I
P
A
G
W
M
G
L
-
D
C
G
P
E
S
S
K
K
Y
S
E
A
V
A
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
Q
G
T
K
A
L
M
D
E
V
V
---
K
A
---
T
-
S
R
GC
I
T
---
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
V
-
13
PsiBlast_PDB
89.41
40%
-99
- C7 -
2P9T
1
PGK2_MOUSE
A:
[8-413]
-------------
L
D
K
V
D
L
K
G
K
R
V
I
M
R
V
D
F
N
V
P
M
K
N
N
-
Q
I
T
N
N
Q
R
I
K
A
A
I
P
S
I
K
H
C
L
D
N
G
A
K
S
V
V
L
M
S
H
L
G
R
P
D
--
G
--
I
P
MP
D
K
Y
S
L
E
P
V
A
D
E
L
K
S
L
L
N
K
D
V
I
F
L
K
D
C
--
V
G
P
E
--
V
E
Q
A
C
A
N
P
D
N
G
S
--------
I
I
L
L
E
N
L
R
F
HVEEE----------
G
K
G
K
------
D
S
--------------
S
G
K
K
-
I
S
A
D
P
A
K
V
E
A
F
R
A
S
L
S
K
L
G
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
----
L
P
Q
--
K
A
S
G
F
L
M
K
K
E
L
D
Y
F
S
K
A
L
E
K
P
E
R
P
F
L
A
I
L
G
G
A
K
V
K
D
K
I
Q
L
I
K
N
M
L
--
D
K
--
V
N
F
M
I
I
G
G
G
M
A
Y
T
F
L
K
E
L
K
N
M
Q
I
G
A
S
L
F
D
E
-------
E
G
A
T
I
V
K
E
I
M
E
K
A
E
K
N
G
V
K
I
V
F
P
V
D
F
V
T
G
D
K
F
-
D
E
N
A
K
V
-
G
-
Q
-----
A
T
I
E
S
G
I
P
S
G
W
M
G
L
D
C
G
P
E
S
I
K
I
N
A
Q
I
V
A
Q
A
K
L
I
V
W
N
G
P
I
G
V
F
E
W
D
A
F
A
K
G
T
K
A
L
M
D
E
V
V
---
K
A
---
T
-
S
N
G
C
V
T
---
I
I
G
G
G
D
T
A
T
C
C
A
K
W
G
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
I
L
P
G
V
E
A
L
S
N
M
-
27
PsiBlast_CBE
89.01
40%
-107
- C7 -
2PAA
1
PGK2_MOUSE
B:
[8-413]
-------------
L
D
K
V
D
L
K
G
K
R
V
I
M
R
V
D
F
N
V
P
M
K
N
N
-
Q
I
T
N
N
Q
R
I
K
A
A
I
P
S
I
K
H
C
L
D
N
G
A
K
S
V
V
L
M
S
H
L
G
R
P
D
--
G
--
I
P
MP
D
K
Y
S
L
E
P
V
A
D
E
L
K
S
L
L
N
K
D
V
I
F
L
K
D
C
--
V
GP
E
--
V
E
Q
A
C
A
N
P
D
N
G
S
--------
I
I
L
L
E
N
L
R
F
HVEEE----------
G
K
G
K
------
D
S
--------------
S
G
K
K
-
I
S
A
D
PAKVEAFRAS
L
S
K
L
G
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
----
L
P
Q
--
K
A
S
G
F
L
M
K
K
E
L
D
Y
F
S
K
A
L
E
K
P
E
R
P
F
L
A
I
L
G
G
A
K
V
K
D
K
I
Q
L
I
K
N
M
L
--
D
K
--
V
N
F
M
I
I
G
G
G
M
A
Y
T
F
L
K
E
L
K
N
M
Q
I
G
A
S
L
F
D
E
-------
E
G
A
T
I
V
K
E
I
M
E
K
A
E
K
N
G
V
K
I
V
F
P
V
D
F
V
T
G
D
K
F
-
D
E
N
A
K
V
-
G
-
Q
-----
A
T
I
E
S
G
I
P
S
G
W
M
G
L
D
C
G
P
E
S
I
K
I
N
A
Q
I
V
A
Q
A
K
L
I
V
W
N
G
P
I
G
V
F
E
W
D
A
F
A
K
G
T
K
A
L
M
D
E
V
V
---
K
A
---
T
-
S
NGC
V
T
---
I
I
G
---------------
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
I
L
P
G
V
E
A
L
S
N
M
-
22
PsiBlast_CBE
88.96
41%
-97
- C7 -
4NG4
2
PGK_COXBU
B:
[16-400]
------------
S
M
S
N
L
N
L
H
N
K
R
V
M
I
R
E
D
L
N
V
P
M
-
K
N
G
K
I
T
N
D
E
R
I
V
R
A
L
P
T
I
Q
K
A
I
E
Q
K
A
R
V
M
I
L
-
S
H
L
G
R
P
E
EG
K
--
F
E
--
K
E
F
S
L
A
P
V
A
R
L
L
S
K
K
L
N
-
K
V
P
L
I
N
D
------
W
--
L
K
G
V
A
V
E
--
P
G
Q
--------
A
I
L
C
E
N
V
R
F
---------------
N
K
G
E
------
N
E
--------------
N
N
T
E
-
L
A
K
R
----------
M
A
E
L
C
D
I
F
V
M
D
A
F
A
T
A
H
R
A
Q
A
S
T
A
G
V
A
A
Y
--
A
K
L
--
A
C
A
G
P
L
L
I
S
E
V
E
A
L
S
R
A
L
E
N
P
Q
K
P
L
V
A
V
V
G
G
S
K
V
S
T
K
I
H
L
L
E
N
L
L
--
D
K
--
V
D
Q
L
I
V
G
G
G
I
A
N
T
F
L
K
A
Q
-
G
Y
S
I
G
K
S
L
C
E
N
-------
E
W
L
D
A
A
Q
Q
F
W
E
K
A
A
E
K
N
V
S
L
P
L
P
V
D
V
I
V
A
D
E
L
-
S
E
D
A
K
A
-
T
-
V
-----
K
N
I
D
A
V
T
S
N
E
S
I
F
-
D
V
G
P
N
T
S
A
T
Y
A
K
L
M
A
Q
A
G
T
I
V
W
N
G
P
I
G
V
F
E
I
E
A
F
S
Q
G
T
R
A
L
A
Q
A
V
A
---
K
S
---
T
-
A
---
Y
S
---
I
V
G
G
G
D
T
L
A
A
L
D
K
F
N
L
T
D
Q
M
S
Y
V
S
T
A
G
G
A
F
L
E
F
L
E
G
K
I
L
P
A
I
K
I
L
T
Q
R
A
21
PsiBlast_CBE
88.58
41%
-99
- C7 -
4NG4
2
PGK_COXBU
C:
[16-400]
------------
S
M
S
N
L
N
L
H
N
K
R
V
M
I
R
E
D
L
N
V
P
M
-
K
N
G
K
I
T
N
D
E
R
I
V
R
A
L
P
T
I
Q
K
A
I
E
Q
K
A
R
V
M
I
L
-
S
H
L
G
R
P
E
EG
K
--
F
E
--
K
E
F
S
L
A
P
V
A
R
L
L
S
K
K
L
N
--
V
P
L
I
N
D
------
W
--
L
K
G
V
A
V
E
--
P
G
Q
--------
A
I
L
C
E
N
V
R
F
---------------
N
K
G
E
------
N
E
--------------
N
N
T
E
-
L
A
K
R
----------
M
A
E
L
C
D
I
F
V
M
D
A
F
A
T
A
H
R
A
Q
A
S
T
A
G
V
A
A
Y
--
A
K
L
--
A
C
A
G
P
L
L
I
S
E
V
E
A
L
S
R
A
L
E
N
P
Q
K
P
L
V
A
V
V
G
G
S
K
V
S
T
K
I
H
L
L
E
N
L
L
--
D
K
--
V
D
Q
L
I
V
G
G
G
I
A
N
T
F
L
K
A
Q
-
G
Y
S
I
G
K
S
L
C
E
N
-------
E
W
L
D
A
A
Q
Q
F
W
E
K
A
A
E
K
N
V
S
L
P
L
P
V
D
V
I
V
A
D
E
L
-
S
E
D
A
K
A
-
T
-
V
-----
K
N
I
D
A
V
T
S
N
E
S
I
F
-
D
V
G
P
N
T
S
A
T
Y
A
K
L
M
A
Q
A
G
T
I
V
W
N
G
P
I
G
V
F
E
I
E
A
F
S
Q
G
T
R
A
L
A
Q
A
V
A
---
K
S
---
T
-
A
---
Y
S
---
I
V
G
G
G
D
T
L
A
A
L
D
K
F
N
L
T
D
Q
M
S
Y
V
S
T
A
G
G
A
F
L
E
F
L
E
G
--
L
P
A
I
K
I
L
T
Q
R
A
4
PsiBlast_PDB
88.50
43%
-99
- C7 -
4FEY
1
PGK_FRATT
A:
[4-392]
----
M
S
F
L
----
T
L
K
D
V
D
L
K
D
K
K
V
L
V
R
V
D
F
N
V
P
V
K
D
G
-
K
V
T
S
K
V
R
I
E
A
A
I
P
T
I
Q
Y
I
L
D
Q
G
G
A
-
V
I
L
M
S
H
L
G
R
P
T
--
E
--
G
E
YD
S
Q
F
S
L
E
P
V
A
K
A
L
S
E
I
I
N
K
P
V
K
F
A
K
D
---------
W
L
D
G
V
D
V
K
A
-
G
E
--------
I
V
M
C
E
N
V
R
F
---------------
N
S
G
E
------
K
K
--------------
S
T
D
D
-
L
S
K
K
----------
I
A
S
L
G
D
V
F
V
M
D
A
F
A
T
A
H
R
A
Q
A
S
T
Y
G
V
A
K
Y
--
I
P
V
--
A
C
A
G
I
L
L
T
N
E
I
Q
A
L
E
K
A
L
K
S
P
K
K
P
M
A
A
I
V
G
G
S
K
V
S
T
K
L
S
V
L
N
N
L
L
--
D
K
--
V
E
I
L
I
V
G
G
G
I
A
N
T
F
I
K
A
E
-
G
F
D
V
G
N
S
L
Y
E
Q
-------
D
L
V
A
E
A
T
E
I
L
A
K
A
K
A
L
G
V
N
I
P
V
P
V
D
V
R
V
A
K
E
F
-
S
E
N
A
Q
A
-
I
-
I
-----
K
K
V
S
D
V
V
A
D
E
M
I
L
-
D
I
G
P
E
S
Q
K
I
I
A
E
L
L
K
S
A
N
T
I
L
W
N
G
P
V
G
V
F
E
F
D
N
F
A
E
G
T
K
A
L
S
L
A
I
A
---
Q
S
---
H
-
A
---
F
S
---
V
A
G
G
G
D
T
I
A
A
I
E
K
F
G
I
K
D
Q
V
S
Y
I
S
T
A
G
G
A
F
L
E
F
L
E
G
K
K
L
P
A
I
E
I
L
K
E
K
A
5
PsiBlast_PDB
87.65
41%
-95
- C7 -
4NG4
2
PGK_COXBU
A:
[16-400]
------------
S
M
S
N
L
N
L
H
N
K
R
V
M
I
R
E
D
L
N
V
P
M
-
K
N
G
K
I
T
N
D
E
R
I
V
R
A
L
P
T
I
Q
K
A
I
E
Q
K
A
R
V
M
I
L
-
S
H
L
G
R
P
E
EG
K
--
F
E
--
K
E
F
S
L
A
P
V
A
R
L
L
S
K
K
-----
P
L
I
N
D
------
W
--
L
K
G
V
A
V
E
--
P
G
Q
--------
A
I
L
C
E
N
V
R
F
---------------
N
K
G
E
------
N
E
--------------
N
N
T
E
-
L
A
K
R
----------
M
A
E
L
C
D
I
F
V
M
D
A
F
A
T
A
H
R
A
Q
A
S
T
A
G
V
A
A
Y
--
A
K
L
--
A
C
A
G
P
L
L
I
S
E
V
E
A
L
S
R
A
L
E
N
P
Q
K
P
L
V
A
V
V
G
G
S
K
V
S
T
K
I
H
L
L
E
N
L
L
--
D
K
--
V
D
Q
L
I
V
G
G
G
I
A
N
T
F
L
K
A
Q
-
G
Y
S
I
G
K
S
L
C
E
N
-------
E
W
L
D
A
A
Q
Q
F
W
E
K
A
A
E
K
N
V
S
L
P
L
P
V
D
V
I
V
A
D
E
L
-
S
E
D
A
K
A
-
T
-
V
-----
K
N
I
D
A
V
T
S
N
E
S
I
F
-
D
V
G
P
N
T
S
A
T
Y
A
K
L
M
A
Q
A
G
T
I
V
W
N
G
P
I
G
V
F
E
I
E
A
F
S
Q
G
T
R
A
L
A
Q
A
V
A
---
K
S
---
T
-
A
---
Y
S
---
I
V
G
G
G
D
T
L
A
A
L
D
K
F
N
L
T
D
Q
M
S
Y
V
S
T
A
G
G
A
F
L
E
F
L
E
G
K
-
L
P
A
I
K
I
L
T
Q
R
A
54
PsiBlast_CBE
87.51
38%
-97
- C7 -
1HDI
3
PGK1_PIG
A:
[5-410]
-------------
L
D
K
L
N
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
-
A
A
A
Q
I
T
N
N
A
R
I
K
A
A
V
P
S
I
K
F
C
L
D
D
G
A
K
S
V
V
L
M
S
H
L
G
R
P
D
--
G
SP
M
P
--
D
K
Y
S
L
Q
P
V
A
A
E
L
K
S
A
L
G
K
A
V
L
F
L
K
D
C
--
V
G
P
A
--
V
E
K
A
C
A
D
P
A
A
G
S
--------
V
I
L
L
E
N
L
R
F
HVEEE----------
G
K
G
K
------
D
A
--------------
S
G
N
K
-
A
A
G
E
P
A
K
I
K
A
F
R
A
S
L
S
A
L
G
D
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
----
L
P
K
--
K
A
G
A
F
L
M
K
K
E
L
N
Y
F
A
A
A
A
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
--
D
K
--
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
N
M
E
I
G
T
S
L
F
D
E
-------
A
G
K
K
I
V
K
N
L
M
S
K
A
A
A
N
G
V
K
I
T
L
P
V
D
F
V
T
A
D
K
F
-
D
E
Q
A
K
I
-
G
-
Q
-----
A
T
V
A
S
G
I
P
A
G
W
M
G
L
D
C
G
P
K
S
S
A
K
Y
S
E
A
V
A
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
Q
G
T
K
A
L
M
D
E
V
V
---
K
A
---
T
-
S
R
GC
I
T
---
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
N
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
V
-
82
HHSearch
83.97
32%
-95
- C7 -
2CUN
5
PGK_PYRHO
A:
[1-401]
----------
M
F
R
L
E
D
F
N
F
H
N
K
T
V
F
L
R
V
D
L
N
S
P
M
K
-
D
G
K
I
I
S
D
A
R
F
K
A
V
L
P
T
I
R
Y
L
I
E
S
G
A
K
-
V
V
I
G
T
H
Q
G
K
P
Y
--
S
--
E
---
D
Y
T
T
T
E
E
H
A
R
V
L
S
E
L
L
D
Q
H
V
E
Y
I
E
D
I
--
F
--
G
R
Y
A
R
E
K
I
K
E
L
K
S
G
E
--------
V
A
I
L
E
N
L
R
F
---------------
S
A
E
E
------
V
K
N
K
P
I
E
E
C
-------
E
K
T
F
-
L
V
K
K
----------
L
S
K
V
I
D
Y
V
V
N
D
A
F
A
T
A
H
R
S
Q
P
S
L
V
G
F
A
R
I
--
K
P
M
---
I
M
G
F
L
M
E
K
E
I
E
A
L
M
R
A
Y
Y
S
K
D
S
P
K
I
Y
V
L
G
G
A
K
V
E
D
S
L
K
V
V
E
N
V
L
--
R
R
ER
A
D
L
V
L
T
G
G
L
V
A
N
V
F
T
L
A
K
-
G
F
D
L
G
R
K
N
V
E
F
M
K
K
K
GLL
D
Y
V
K
H
A
E
E
I
L
D
E
F
---
Y
P
Y
I
R
T
P
V
D
F
A
V
D
Y
K
G
-
E
R
V
-
E
I
-
D
L
L
-----
S
E
N
R
G
L
L
H
Q
Y
Q
I
M
-
D
I
G
K
R
T
A
E
K
Y
R
E
I
L
M
K
A
R
I
I
V
A
N
G
P
M
G
V
F
E
R
E
E
F
A
I
G
T
V
E
V
F
K
A
I
A
---
D
S
---
P
-
A
---
F
S
---
V
L
G
G
G
H
S
I
A
S
I
Q
K
Y
G
I
-
T
G
I
T
H
I
S
T
G
G
G
A
M
L
S
F
F
A
G
E
E
L
P
V
L
R
A
L
Q
I
S
Y
57
PsiBlast_CBE
82.29
31%
-89
- C7 -
2CUN
5
PGK_PYRHO
A:
[3-398]
------------
R
L
E
D
F
N
F
H
N
K
T
V
F
L
R
V
D
L
N
S
P
M
K
D
G
-
K
I
I
S
D
A
R
F
K
A
V
L
P
T
I
R
Y
L
I
E
S
G
A
K
-
V
V
I
G
T
H
Q
G
K
P
Y
--
S
---
E
--
D
Y
T
T
T
E
E
H
A
R
V
L
S
E
L
L
D
Q
H
V
E
Y
I
E
D
I
FG
R
--
Y
--
A
R
E
K
I
K
E
L
K
S
G
E
--------
V
A
I
L
E
N
L
R
F
---------------
S
A
E
E
V
K
N
K
P
I
E
E
--------------
C
E
K
T
F
L
V
K
K
----------
L
S
K
V
I
D
Y
V
V
N
D
A
F
A
T
A
H
R
S
Q
P
S
L
V
G
F
A
R
I
--
K
P
M
---
I
M
G
F
L
M
E
K
E
I
E
A
L
M
R
A
Y
Y
S
K
D
S
P
K
I
Y
V
L
G
G
A
K
V
E
D
S
L
K
V
V
E
N
V
L
R
R
E
R
--
A
D
L
V
L
T
G
G
L
V
A
N
V
F
T
L
A
K
-
G
F
D
L
G
R
K
N
V
E
F
-------
M
K
K
K
G
L
L
D
Y
V
K
H
A
E
E
I
L
D
E
F
Y
-
P
Y
I
R
T
P
V
D
F
A
-
V
D
Y
K
G
E
-
R
-
V
E
I
D
LL
S
E
N
R
G
L
L
H
Q
Y
Q
I
M
-
D
I
G
K
R
T
A
E
K
Y
R
E
I
L
M
K
A
R
I
I
V
A
N
G
P
M
G
V
F
E
R
E
E
F
A
I
G
T
V
E
V
F
K
A
I
A
---
D
S
---
P
-
A
---
F
S
---
V
L
G
G
G
H
S
I
A
S
I
Q
K
Y
G
-
I
T
G
I
T
H
I
S
T
G
G
G
A
M
L
S
F
F
A
G
E
E
L
P
V
L
R
A
L
Q
I
S
Y
56
PsiBlast_CBE
80.96
31%
-86
- C7 -
2CUN
5
PGK_PYRHO
B:
[3-398]
------------
R
L
E
D
F
N
F
H
N
K
T
V
F
L
R
V
D
L
N
S
P
M
K
D
G
-
K
I
I
S
D
A
R
F
K
A
V
L
P
T
I
R
Y
L
I
E
S
G
A
K
-
V
V
I
G
T
H
Q
G
K
P
Y
--
S
---
E
--
D
Y
T
T
T
E
E
H
A
R
V
L
S
E
L
L
D
Q
H
V
E
Y
I
E
D
I
FG
R
--
Y
--
A
R
E
K
I
K
E
L
K
S
G
E
--------
V
A
I
L
E
N
L
R
F
---------------
S
A
E
E
VKNKPI
E
E
--------------
C
E
K
T
F
L
V
K
K
----------
L
S
K
V
I
D
Y
V
V
N
D
A
F
A
T
A
H
R
S
Q
P
S
L
V
G
F
A
R
I
--
K
P
M
---
I
M
G
F
L
M
E
K
E
I
E
A
L
M
R
A
Y
Y
S
K
D
S
P
K
I
Y
V
L
G
G
A
K
V
E
D
S
L
K
V
V
E
N
V
L
RR
E
R
--
A
D
L
V
L
T
G
G
L
V
A
N
V
F
T
L
A
K
-
G
F
D
L
G
R
K
N
V
E
F
-------
M
K
K
K
G
L
L
D
Y
V
K
H
A
E
E
I
L
D
E
F
Y
-
P
Y
I
R
T
P
V
D
F
A
-
V
D
Y
K
G
E
-
R
-
V
EIDLL
S
E
N
R
G
L
L
H
Q
Y
Q
I
M
-
D
I
G
K
R
T
A
E
K
Y
R
E
I
L
M
K
A
R
I
I
V
A
N
G
P
M
G
V
F
E
R
E
E
F
A
I
G
T
V
E
V
F
K
A
I
A
---
D
S
---
P
-
A
---
F
S
---
V
L
G
G
G
H
S
I
A
S
I
Q
K
Y
G
-
I
T
G
I
T
H
I
S
T
G
G
G
A
M
L
S
F
F
A
G
E
E
L
P
V
L
R
A
L
Q
I
S
Y
83
HHSearch
76.01
41%
-85
- C7 -
1FW8
5
PGK_YEAST
A:
[1-343]
-----------------------------------------------------------------------------------
S
K
Y
S
L
A
P
V
A
K
E
L
Q
S
L
L
G
K
D
V
T
F
L
N
D
C
--
V
--
G
P
E
V
E
A
A
V
K
A
S
A
P
G
S
--------
V
I
L
L
E
N
L
R
Y
---------------
H
I
E
E
------
E
G
S
R
K
V
DG
Q
K
V
K
A
S
K
E
D
V
Q
K
-
F
R
H
E
----------
L
S
S
L
A
D
V
Y
I
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
F
D
----
L
P
Q
--
R
A
A
G
F
L
L
E
K
E
L
K
Y
F
G
K
A
L
E
N
P
T
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
D
N
L
L
--
D
K
--
V
D
S
I
I
I
G
G
G
M
A
F
T
F
K
K
V
L
E
N
T
E
I
G
D
S
I
F
D
K
-------
A
G
A
E
I
V
P
K
L
M
E
K
A
K
A
K
G
V
E
V
V
L
P
V
D
F
I
I
A
D
A
F
-
S
A
D
A
N
T
-
K
T
V
-----
T
D
K
E
G
I
P
A
G
W
Q
G
L
-
D
N
G
P
E
S
R
K
L
F
A
A
T
V
A
K
A
K
T
I
V
W
N
G
P
P
G
V
F
E
F
E
K
F
A
A
G
T
K
A
L
L
D
E
V
V
---
K
S
S
A
A
G
-
N
---
T
V
---
I
I
G
G
G
D
T
A
T
V
A
K
K
Y
G
V
T
D
K
I
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
E
L
P
G
V
A
F
L
S
E
K
K
48
PsiBlast_CBE
59.36
40%
4
- C7 -
3PGK
3
PGK_YEAST
A:
[10-415]
------------
S
V
Q
D
L
D
L
K
D
K
R
V
F
I
R
V
D
F
N
V
P
L
D
G
K
-
K
I
T
S
N
Q
R
I
V
A
A
L
P
T
I
K
Y
V
L
E
H
H
P
R
Y
V
V
L
A
S
H
L
G
R
P
N
--
G
--
E
R
N-
E
K
Y
S
L
A
P
V
A
K
E
L
Q
S
L
L
G
K
D
V
T
F
L
N
D
C
--
V
G
P
E
--
V
E
A
A
V
K
A
S
A
P
G
S
--------
V
I
L
L
E
N
L
R
Y
HIEEEGSRKV
D
G
Q
K
-
V
K
A
S
------
K
E
--------------
D
V
Q
K
-
F
R
H
E
----------
L
S
S
L
A
D
V
Y
I
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
F
D
----
L
P
Q
--
R
A
A
G
F
L
L
E
K
E
L
K
Y
F
G
K
A
L
E
N
P
T
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
D
N
L
L
--
D
K
--
V
D
S
I
I
I
G
G
G
M
A
F
T
F
K
K
V
L
E
N
T
E
I
G
D
S
I
F
D
K
-------
A
V
G
P
E
I
A
K
L
M
E
K
A
K
A
K
G
V
E
V
V
L
P
V
D
F
I
I
A
D
A
F
-
S
A
S
A
N
T
-
K
T
V
-----
T
D
K
E
G
I
P
A
G
W
Q
G
L
-
D
N
G
P
E
S
R
K
L
F
A
A
T
V
A
K
A
T
V
I
L
W
N
G
P
P
G
V
F
E
F
E
K
F
A
A
G
T
K
A
L
L
D
E
V
V
---
K
S
---
S
-
A
---
A
G
N
T
V
I
I
G
G
G
D
T
A
T
V
A
K
K
Y
G
V
T
D
K
I
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
E
L
P
G
V
A
F
L
S
E
K
K
84
HHSearch
40.92
44%
-70
- C7 -
1FW8
2
PGK_YEAST
A:
[344-413]
-----
K
S
L
S
S
K
L
S
V
Q
D
L
D
L
K
D
K
R
V
F
I
R
V
D
F
N
V
P
L
D
G
-
K
K
I
T
S
N
Q
R
I
V
A
A
L
P
T
I
K
Y
V
L
E
H
H
P
R
Y
V
V
L
A
S
H
L
G
R
P
N
--
G
--
E
R
--
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------