@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_1265: (2015-12-22 )
MPIKIAINGTGRIGLCAIRVASQRKDVEIVAINSTAELETLLHLIRHDSVHGHFEAKLNANRTLNIGHSKNILVLSERDINKLDFSVANAEIIIECTGKFNSLEASSAHLKNSVKKVIISAPAQNAPTFVYGVNHTNYHNESVISNASCTTNATAPLLKILDEAFKVENALLTTIHSYTNDQNLLDTKHKDIRRARAASLNLIPTSTGVSKAISLVLPHLGPKITGLAIRVPTPNVSLVDLSLNFKKVVSKASVQHALKDASKHAFKGIVSVDEERLVSSDFISSPFSAIVIDDQIMTIGEKNAKVLAWYDNEMGYSERLIDMAQYIAQN
Atome Classification :
(45 SA)
.........10........--20---..--..---.--...30....-....40........50...--.-.--...60.........70........80........90........100.......110.......120..-.-.--.-..130......-.-140.-.--.......150.......160.......170.......180.......--190.......200.......210.......220.......230.......240......-.250.......260.-------......270.......280.......290.......300.......310.......320.......330
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
P
I
K
I
A
INGTG
R
I
G
L
C
A
I
R
--VA---SQ--RK---
D
--
V
E
I
V
A
INS
T
-
A
E
L
E
T
L
L
H
L
I
RHDSVH
G
H
F
--
E
-
A
--KLNA-N
R
T
L
NIGHSK
N
I
L
V
L
SERDI
N
K
LDFSVAN
A
E
I
I
I
E
CTGKFNSLEA
S
S
A
H
L
K
N
S
V
K
K
V
IISAPAQ-N-A--
P
-
T
F
V
Y
GVNHTNY-H-N--E-S--VISNASCTTNAT
A
P
L
L
K
I
L
D
E
A
F
K
V
E
N
A
L
L
T
T
I
H
SYTNDQNLL
D
T
K
H
--
K
D
I
R
R
A
RAAS
L
N
L
I
PTST
G
V
S
K
A
I
S
L
V
L
PHLGPK
I
T
G
L
A
I
RVPTPN
V
S
L
V
D
LSL
N
F
K
K
V
-
V
S
K
A
S
V
Q
H
A
L
K
D
A
S
K
-------
H
A
F
K
G
I
VSV
D
E
E
R
LV
S
S
D
FISSP
F
S
A
I
V
IDD
Q
I
M
TIGEKN
A
K
V
L
A
W
YDNEM
G
Y
S
E
R
L
I
D
M
A
Q
Y
I
AQN
71
PsiBlast_CBE
95.37
45%
-91
- C4 -
3GNQ
2
?
C:
[10-341]
-
T
I
R
V
A
I
N
G
Y
G
R
I
G
R
N
T
L
R
--
A
F
YEN
G
K
--
K
H
---
D
--
L
E
I
V
A
I
N
D
L
-
G
D
A
K
T
N
A
H
L
T
Q
Y
D
T
A
H
G
K
F
--
P
-
G
--
E
V
S
V
-
D
G
D
Y
L
V
V
N
G
D
R
I
R
V
L
A
N
R
N
P
A
E
L
P
W
G
E
L
G
V
D
V
V
M
E
C
T
G
F
F
T
S
K
E
K
A
S
A
H
L
K
G
G
A
K
K
V
I
I
S
A
P
G
G
-
K
-
D
VD
A
-
T
I
V
Y
G
V
N
H
D
V
L
-
K
-
A
--
E
H
T
--
V
I
S
N
A
S
C
T
T
N
C
L
A
P
L
V
K
P
L
N
D
K
I
G
L
E
T
G
L
M
T
T
I
H
A
Y
T
N
D
Q
V
L
T
D
V
Y
H
--
E
D
L
R
R
A
R
S
A
T
H
S
Q
I
P
T
K
T
G
A
A
A
A
V
G
L
V
L
P
E
L
N
G
K
L
D
G
Y
A
I
R
V
P
T
I
N
V
S
I
V
D
L
S
F
I
A
K
R
D
-
T
T
A
A
E
V
N
A
I
M
K
E
A
S
E
-------
G
A
L
K
G
I
L
G
Y
N
E
A
P
L
V
S
I
D
F
N
H
N
P
A
S
S
-
T
F
D
A
T
L
T
K
V
S
G
R
L
V
K
V
S
S
W
Y
D
N
E
W
G
F
S
N
R
M
L
D
T
A
I
A
L
A
N
A
68
PsiBlast_CBE
95.24
45%
-94
- C4 -
3GNQ
2
?
F:
[10-341]
-
T
I
R
V
A
I
N
G
Y
G
R
I
G
R
N
T
L
R
--
A
F
YEN
G
K
--
K
H
---
D
--
L
E
I
V
A
I
N
D
L
-
G
D
A
K
T
N
A
H
L
T
Q
Y
D
T
A
H
G
K
F
--
P
-
G
--
E
V
S
V
-
D
G
D
Y
L
V
V
N
G
D
R
I
R
V
L
A
N
R
N
P
A
E
L
P
W
G
E
L
G
V
D
V
V
M
E
C
T
G
F
F
T
S
K
E
K
A
S
A
H
L
K
G
G
A
K
K
V
I
I
S
A
P
G
G
-
K
-
D
VD
A
-
T
I
V
Y
G
V
N
H
D
V
L
-
K
-
A
--
E
H
T
--
V
I
S
N
A
S
C
T
T
N
C
L
A
P
L
V
K
P
L
N
D
K
I
G
L
E
T
G
L
M
T
T
I
H
A
Y
T
N
D
Q
V
L
T
D
V
Y
H
--
E
D
L
R
R
A
R
S
A
T
H
S
Q
I
P
T
K
T
G
A
A
A
A
V
G
L
V
L
P
E
L
N
G
K
L
D
G
Y
A
I
R
V
P
T
I
N
V
S
I
V
D
L
S
F
I
A
K
R
D
-
T
T
A
A
E
V
N
A
I
M
K
E
A
S
E
-------
G
A
L
K
G
I
L
G
Y
N
E
A
P
L
V
S
I
D
F
N
H
N
P
A
S
S
-
T
F
D
A
T
L
T
K
V
S
G
R
L
V
K
V
S
S
W
Y
D
N
E
W
G
F
S
N
R
M
L
D
T
A
I
A
L
A
N
A
118
HHSearch
94.71
48%
-98
- C4 -
3CMC
14
G3P_GEOSE
O:
[1-332]
-
A
V
K
V
G
I
N
G
F
G
R
I
G
R
N
V
F
R
--
A
A
---
L
K
--
N
P
---
D
--
I
E
V
V
A
V
N
D
L
-
T
D
A
N
T
L
A
H
L
L
K
Y
D
S
V
H
G
R
L
DA
E
-
V
--
S
V
-
N
-
G
N
N
L
V
V
N
-
G
K
E
I
I
V
K
A
E
R
D
P
E
N
L
A
W
G
E
I
G
V
D
I
V
V
E
S
T
G
R
F
T
K
R
E
D
A
A
K
H
L
E
A
G
A
K
K
V
I
I
S
A
P
A
K
-
N
E
D
--
I
-
T
I
V
M
G
V
N
Q
D
K
Y
-
D
-
P
KA
H
-
H
--
V
I
S
N
A
S
C
T
T
N
C
L
A
P
F
A
K
V
L
H
E
Q
F
G
I
V
R
G
M
M
T
T
V
H
S
Y
T
N
D
Q
R
I
L
D
L
P
H
--
K
D
L
R
R
A
R
A
A
A
E
S
I
I
P
T
T
T
G
A
A
K
A
V
A
L
V
L
P
E
L
K
G
K
L
N
G
M
A
M
R
V
P
T
P
N
V
S
V
V
D
L
V
A
E
L
E
K
E
-
V
T
V
E
E
V
N
A
A
L
K
A
A
A
E
-------
G
E
L
K
G
I
L
A
Y
S
E
E
P
L
V
S
R
D
Y
N
G
S
T
V
S
S
T
I
D
A
L
S
T
M
V
I
D
G
K
M
V
K
V
V
S
W
Y
D
N
E
T
G
Y
S
H
R
V
V
D
L
A
A
Y
I
A
S
K
19
PsiBlast_PDB
94.63
45%
-92
- C4 -
3GNQ
1
?
A:
[10-341]
-
T
I
R
V
A
I
N
G
Y
G
R
I
G
R
N
T
L
R
--
A
F
Y
E
N
G
K
--
K
H
---
D
--
L
E
I
V
A
I
N
D
L
-
G
D
A
K
T
N
A
H
L
T
Q
Y
D
T
A
H
G
K
F
--
P
-
G
--
E
V
S
V
-
D
G
D
Y
L
V
V
N
G
D
R
I
R
V
L
A
N
R
N
P
A
E
L
P
W
G
E
L
G
V
D
V
V
M
E
C
T
G
F
F
T
S
K
E
K
A
S
A
H
L
K
G
G
A
K
K
V
I
I
S
A
P
G
G
-
K
-
D
VD
A
-
T
I
V
Y
G
V
N
H
D
V
L
-
K
-
A
--
E
H
T
--
V
I
S
N
A
S
C
T
T
N
C
L
A
P
L
V
K
P
L
N
D
K
I
G
L
E
T
G
L
M
T
T
I
H
A
Y
T
N
D
Q
V
L
T
D
V
Y
H
--
E
D
L
R
R
A
R
S
A
T
H
S
Q
I
P
T
K
T
G
A
A
A
A
V
G
L
V
L
P
E
L
N
G
K
L
D
G
Y
A
I
R
V
P
T
I
N
V
S
I
V
D
L
S
F
I
A
K
R
D
-
T
T
A
A
E
V
N
A
I
M
K
E
A
S
E
-------
G
A
L
K
G
I
L
G
Y
N
E
A
P
L
V
S
I
D
F
N
H
N
P
A
S
S
-
T
F
D
A
T
L
T
K
V
S
G
R
L
V
K
V
S
S
W
Y
D
N
E
W
G
F
S
N
R
M
L
D
T
A
I
A
L
A
N
A
5
PsiBlast_PDB
94.42
47%
-98
- C4 -
1GD1
4
G3P_GEOSE
O:
[2-330]
--
V
K
V
G
I
N
G
F
G
R
I
G
R
N
V
F
R
--
A
A
---
L
K
--
N
P
---
D
--
I
E
V
V
A
V
N
D
L
-
T
D
A
N
T
L
A
H
L
L
K
Y
D
S
V
H
G
R
L
--
D
-
A
--
E
V
S
V
-
N
G
N
N
L
V
V
N
G
K
E
I
I
V
K
A
E
R
D
P
E
N
L
A
W
G
E
I
G
V
D
I
V
V
E
S
T
G
R
F
T
K
R
E
D
A
A
K
H
L
E
A
G
A
K
K
V
I
I
S
A
P
A
K
-
N
-
E
--
D
I
T
I
V
M
G
V
N
Q
D
K
Y
-
D
-
P
--
K
-
A
HH
V
I
S
N
A
S
C
T
T
N
C
L
A
P
F
A
K
V
L
H
E
Q
F
G
I
V
R
G
M
M
T
T
V
H
S
Y
T
N
D
Q
R
I
L
D
L
P
H
--
K
D
L
R
R
A
R
A
A
A
E
S
I
I
P
T
T
T
G
A
A
K
A
V
A
L
V
L
P
E
L
K
G
K
L
N
G
M
A
M
R
V
P
T
P
N
V
S
V
V
D
L
V
A
E
L
E
K
E
-
V
T
V
E
E
V
N
A
A
L
K
A
A
A
E
-------
G
E
L
K
G
I
L
A
Y
S
E
E
P
L
V
S
R
D
Y
N
G
S
T
V
S
S
T
I
D
A
L
S
T
M
V
I
D
G
K
M
V
K
V
V
S
W
Y
D
N
E
T
G
Y
S
H
R
V
V
D
L
A
A
Y
I
A
S
K
48
PsiBlast_CBE
94.35
47%
-99
- C4 -
1NQO
2
G3P_GEOSE
Q:
[2-330]
--
V
K
V
G
I
N
G
F
G
R
I
G
R
N
V
F
R
--
A
A
---
L
K
--
N
P
---
D
--
I
E
V
V
A
V
N
D
L
-
T
D
A
N
T
L
A
H
L
L
K
Y
D
S
V
H
G
R
L
--
D
-
A
--
E
V
S
V
-
N
G
N
N
L
V
V
N
G
K
E
I
I
V
K
A
E
R
D
P
E
N
L
A
W
G
E
I
G
V
D
I
V
V
E
S
T
G
R
F
T
K
R
E
D
A
A
K
H
L
E
A
G
A
K
K
V
I
I
S
A
P
A
K
-
N
-
E
--
D
I
T
I
V
M
G
V
N
Q
D
K
Y
-
D
-
P
--
K
-
A
HH
V
I
S
N
A
S
S
T
T
N
C
L
A
P
F
A
K
V
L
H
E
Q
F
G
I
V
R
G
M
M
T
T
V
H
S
Y
T
N
D
Q
R
I
L
D
L
P
H
--
K
D
L
R
R
A
R
A
A
A
E
S
I
I
P
T
T
T
G
A
A
K
A
V
A
L
V
L
P
E
L
K
G
K
L
N
G
M
A
M
R
V
P
T
P
N
V
S
V
V
D
L
V
A
E
L
E
K
E
-
V
T
V
E
E
V
N
A
A
L
K
A
A
A
E
-------
G
E
L
K
G
I
L
A
Y
S
E
E
P
L
V
S
R
D
Y
N
G
S
T
V
S
S
T
I
D
A
L
S
T
M
V
I
D
G
K
M
V
K
V
V
S
W
Y
D
N
E
T
G
Y
S
H
R
V
V
D
L
A
A
Y
I
A
S
K
41
PsiBlast_CBE
94.33
47%
-99
- C4 -
1GD1
4
G3P_GEOSE
P:
[2-330]
--
V
K
V
G
I
N
G
F
G
R
I
G
R
N
V
F
R
--
A
A
---
L
K
--
N
P
---
D
--
I
E
V
V
A
V
N
D
L
-
T
D
A
N
T
L
A
H
L
L
K
Y
D
S
V
H
G
R
L
--
D
-
A
--
E
V
S
V
-
N
G
N
N
L
V
V
N
G
K
E
I
I
V
K
A
E
R
D
P
E
N
L
A
W
G
E
I
G
V
D
I
V
V
E
S
T
G
R
F
T
K
R
E
D
A
A
K
H
L
E
A
G
A
K
K
V
I
I
S
A
P
A
K
-
N
-
E
--
D
I
T
I
V
M
G
V
N
Q
D
K
Y
-
D
-
P
--
K
-
A
HH
V
I
S
N
A
S
C
T
T
N
C
L
A
P
F
A
K
V
L
H
E
Q
F
G
I
V
R
G
M
M
T
T
V
H
S
Y
T
N
D
Q
R
I
L
D
L
P
H
--
K
D
L
R
R
A
R
A
A
A
E
S
I
I
P
T
T
T
G
A
A
K
A
V
A
L
V
L
P
E
L
K
G
K
L
N
G
M
A
M
R
V
P
T
P
N
V
S
V
V
D
L
V
A
E
L
E
K
E
-
V
T
V
E
E
V
N
A
A
L
K
A
A
A
E
-------
G
E
L
K
G
I
L
A
Y
S
E
E
P
L
V
S
R
D
Y
N
G
S
T
V
S
S
T
I
D
A
L
S
T
M
V
I
D
G
K
M
V
K
V
V
S
W
Y
D
N
E
T
G
Y
S
H
R
V
V
D
L
A
A
Y
I
A
S
K
66
PsiBlast_CBE
94.23
45%
-92
- C4 -
3GNQ
2
?
H:
[10-341]
-
T
I
R
V
A
I
N
G
Y
G
R
I
G
R
N
T
L
R
--
A
F
YEN
G
K
--
K
H
---
D
--
L
E
I
V
A
I
N
D
L
-
G
D
A
K
T
N
A
H
L
T
Q
Y
D
T
A
H
G
K
F
--
P
-
G
--
E
V
S
V
-
D
G
D
Y
L
V
V
N
G
D
R
I
R
V
L
A
N
R
N
P
A
E
L
P
W
G
E
L
G
V
D
V
V
M
E
C
T
G
F
F
T
S
K
E
K
A
S
A
H
L
K
G
G
A
K
K
V
I
I
S
A
P
G
G
-
K
-
D
VD
A
-
T
I
V
Y
G
V
N
H
D
V
L
-
K
-
A
--
E
H
T
--
V
I
S
N
A
S
C
T
T
N
C
L
A
P
L
V
K
P
L
N
D
K
I
G
L
E
T
G
L
M
T
T
I
H
A
Y
T
N
D
Q
V
L
T
D
V
Y
H
--
E
D
L
R
R
A
R
S
A
T
H
S
Q
I
P
T
K
T
G
A
A
A
A
V
G
L
V
L
P
E
L
N
G
K
L
D
G
Y
A
I
R
V
P
T
I
N
V
S
I
V
D
L
S
F
I
A
K
R
D
-
T
T
A
A
E
V
N
A
I
M
K
E
A
S
E
-------
G
A
L
K
G
I
L
G
Y
N
E
A
P
L
V
S
I
D
F
N
H
N
P
A
S
S
-
T
F
D
A
T
L
T
K
V
S
G
R
L
V
K
V
S
S
W
Y
D
N
E
W
G
F
S
N
R
M
L
D
T
A
I
A
L
A
N
A
70
PsiBlast_CBE
94.13
45%
-97
- C4 -
3GNQ
2
?
D:
[10-341]
-
T
I
R
V
A
I
N
G
Y
G
R
I
G
R
N
T
L
R
--
A
F
YEN
G
K
--
K
H
---
D
--
L
E
I
V
A
I
N
D
L
-
G
D
A
K
T
N
A
H
L
T
Q
Y
D
T
A
H
G
K
F
--
P
-
G
--
E
V
S
V
-
D
G
D
Y
L
V
V
N
G
D
R
I
R
V
L
A
N
R
N
P
A
E
L
P
W
G
E
L
G
V
D
V
V
M
E
C
T
G
F
F
T
S
K
E
K
A
S
A
H
L
K
G
G
A
K
K
V
I
I
S
A
P
G
G
-
K
-
D
VD
A
-
T
I
V
Y
G
V
N
H
D
V
L
-
K
-
A
--
E
H
T
--
V
I
S
N
A
S
C
T
T
N
C
L
A
P
L
V
K
P
L
N
D
K
I
G
L
E
T
G
L
M
T
T
I
H
A
Y
T
N
D
Q
V
L
T
D
V
Y
H
--
E
D
L
R
R
A
R
S
A
T
H
S
Q
I
P
T
K
T
G
A
A
A
A
V
G
L
V
L
P
E
L
N
G
K
L
D
G
Y
A
I
R
V
P
T
I
N
V
S
I
V
D
L
S
F
I
A
K
R
D
-
T
T
A
A
E
V
N
A
I
M
K
E
A
S
E
-------
G
A
L
K
G
I
L
G
Y
N
E
A
P
L
V
S
I
D
F
N
H
N
P
A
S
S
-
T
F
D
A
T
L
T
K
V
S
G
R
L
V
K
V
S
S
W
Y
D
N
E
W
G
F
S
N
R
M
L
D
T
A
I
A
L
A
N
A
34
PsiBlast_CBE
94.05
47%
-97
- C4 -
3CMC
5
G3P_GEOSE
Q:
[2-330]
--
V
K
V
G
I
N
G
F
G
R
I
G
R
N
V
F
R
--
A
A
---
L
K
--
N
P
---
D
--
I
E
V
V
A
V
N
D
L
-
T
D
A
N
T
L
A
H
L
L
K
Y
D
S
V
H
G
R
L
--
D
-
A
--
E
V
S
V
-
N
G
N
N
L
V
V
N
G
K
E
I
I
V
K
A
E
R
D
P
E
N
L
A
W
G
E
I
G
V
D
I
V
V
E
S
T
G
R
F
T
K
R
E
D
A
A
K
H
L
E
A
G
A
K
K
V
I
I
S
A
P
A
K
-
N
-
E
--
D
I
T
I
V
M
G
V
N
Q
D
K
Y
-
D
-
P
--
K
-
A
HH
V
I
S
N
A
S
C
T
T
N
C
L
A
P
F
A
K
V
L
H
E
Q
F
G
I
V
R
G
M
M
T
T
V
H
S
Y
T
N
D
Q
R
I
L
D
L
P
H
--
K
D
L
R
R
A
R
A
A
A
E
S
I
I
P
T
T
T
G
A
A
K
A
V
A
L
V
L
P
E
L
K
G
K
L
N
G
M
A
M
R
V
P
T
P
N
V
S
V
V
D
L
V
A
E
L
E
K
E
-
V
T
V
E
E
V
N
A
A
L
K
A
A
A
E
-------
G
E
L
K
G
I
L
A
Y
S
E
E
P
L
V
S
R
D
Y
N
G
S
T
V
S
S
T
I
D
A
L
S
T
M
V
I
D
G
K
M
V
K
V
V
S
W
Y
D
N
E
T
G
Y
S
H
R
V
V
D
L
A
A
Y
I
A
S
K
49
PsiBlast_CBE
94.04
47%
-97
- C4 -
1NQO
2
G3P_GEOSE
C:
[2-330]
--
V
K
V
G
I
N
G
F
G
R
I
G
R
N
V
F
R
--
A
A
---
L
K
--
N
P
---
D
--
I
E
V
V
A
V
N
D
L
-
T
D
A
N
T
L
A
H
L
L
K
Y
D
S
V
H
G
R
L
--
D
-
A
--
E
V
S
V
-
N
G
N
N
L
V
V
N
G
K
E
I
I
V
K
A
E
R
D
P
E
N
L
A
W
G
E
I
G
V
D
I
V
V
E
S
T
G
R
F
T
K
R
E
D
A
A
K
H
L
E
A
G
A
K
K
V
I
I
S
A
P
A
K
-
N
-
E
--
D
I
T
I
V
M
G
V
N
Q
D
K
Y
-
D
-
P
--
K
-
A
HH
V
I
S
N
A
S
S
T
T
N
C
L
A
P
F
A
K
V
L
H
E
Q
F
G
I
V
R
G
M
M
T
T
V
H
S
Y
T
N
D
Q
R
I
L
D
L
P
H
--
K
D
L
R
R
A
R
A
A
A
E
S
I
I
P
T
T
T
G
A
A
K
A
V
A
L
V
L
P
E
L
K
G
K
L
N
G
M
A
M
R
V
P
T
P
N
V
S
V
V
D
L
V
A
E
L
E
K
E
-
V
T
V
E
E
V
N
A
A
L
K
A
A
A
E
-------
G
E
L
K
G
I
L
A
Y
S
E
E
P
L
V
S
R
D
Y
N
G
S
T
V
S
S
T
I
D
A
L
S
T
M
V
I
D
G
K
M
V
K
V
V
S
W
Y
D
N
E
T
G
Y
S
H
R
V
V
D
L
A
A
Y
I
A
S
K
69
PsiBlast_CBE
94.02
45%
-92
- C4 -
3GNQ
2
?
E:
[10-341]
-
T
I
R
V
A
I
N
G
Y
G
R
I
G
R
N
T
L
R
--
A
F
YEN
G
K
--
K
H
---
D
--
L
E
I
V
A
I
N
D
L
-
G
D
A
K
T
N
A
H
L
T
Q
Y
D
T
A
H
G
K
F
--
P
-
G
--
E
V
S
V
-
D
G
D
Y
L
V
V
N
G
D
R
I
R
V
L
A
N
R
N
P
A
E
L
P
W
G
E
L
G
V
D
V
V
M
E
C
T
G
F
F
T
S
K
E
K
A
S
A
H
L
K
G
G
A
K
K
V
I
I
S
A
P
G
G
-
K
-
D
VD
A
-
T
I
V
Y
G
V
N
H
D
V
L
-
K
-
A
--
E
H
T
--
V
I
S
N
A
S
C
T
T
N
C
L
A
P
L
V
K
P
L
N
D
K
I
G
L
E
T
G
L
M
T
T
I
H
A
Y
T
N
D
Q
V
L
T
D
V
Y
H
--
E
D
L
R
R
A
R
S
A
T
H
S
Q
I
P
T
K
T
G
A
A
A
A
V
G
L
V
L
P
E
L
N
G
K
L
D
G
Y
A
I
R
V
P
T
I
N
V
S
I
V
D
L
S
F
I
A
K
R
D
-
T
T
A
A
E
V
N
A
I
M
K
E
A
S
E
-------
G
A
L
K
G
I
L
G
Y
N
E
A
P
L
V
S
I
D
F
N
H
N
P
A
S
S
-
T
F
D
A
T
L
T
K
V
S
G
R
L
V
K
V
S
S
W
Y
D
N
E
W
G
F
S
N
R
M
L
D
T
A
I
A
L
A
N
A
47
PsiBlast_CBE
93.90
47%
-97
- C4 -
1NPT
3
G3P_GEOSE
P:
[2-330]
--
V
K
V
G
I
N
G
F
G
R
I
G
R
N
V
F
R
--
A
A
---
L
K
--
N
P
---
D
--
I
E
V
V
A
V
N
D
L
-
T
D
A
N
T
L
A
H
L
L
K
Y
D
S
V
H
G
R
L
--
D
-
A
--
E
V
S
V
-
N
G
N
N
L
V
V
N
G
K
E
I
I
V
K
A
E
R
D
P
E
N
L
A
W
G
E
I
G
V
D
I
V
V
E
S
T
G
R
F
T
K
R
E
D
A
A
K
H
L
E
A
G
A
K
K
V
I
I
S
A
P
A
K
-
N
-
E
--
D
I
T
I
V
M
G
V
N
Q
D
K
Y
-
D
-
P
--
K
-
A
HH
V
I
S
N
A
S
A
T
T
N
C
L
A
P
F
A
K
V
L
H
E
Q
F
G
I
V
R
G
M
M
T
T
V
H
S
Y
T
N
D
Q
R
I
L
D
L
P
H
--
K
D
L
R
R
A
R
A
A
A
E
S
I
I
P
T
T
T
G
A
A
K
A
V
A
L
V
L
P
E
L
K
G
K
L
N
G
M
A
M
R
V
P
T
P
N
V
S
V
V
D
L
V
A
E
L
E
K
E
-
V
T
V
E
E
V
N
A
A
L
K
A
A
A
E
-------
G
E
L
K
G
I
L
A
Y
S
E
E
P
L
V
S
R
D
Y
N
G
S
T
V
S
S
T
I
D
A
L
S
T
M
V
I
D
G
K
M
V
K
V
V
S
W
Y
D
N
E
T
G
Y
S
H
R
V
V
D
L
A
A
Y
I
A
S
K
72
PsiBlast_CBE
93.89
45%
-91
- C4 -
3GNQ
1
?
B:
[10-341]
-
T
I
R
V
A
I
N
G
Y
G
R
I
G
R
N
T
L
R
--
A
F
YEN
G
K
--
K
H
---
D
--
L
E
I
V
A
I
N
D
L
-
G
D
A
K
T
N
A
H
L
T
Q
Y
D
T
A
H
G
K
F
--
P
-
G
--
E
V
S
V
-
D
G
D
Y
L
V
V
N
G
D
R
I
R
V
L
A
N
R
N
P
A
E
L
P
W
G
E
L
G
V
D
V
V
M
E
C
T
G
F
F
T
S
K
E
K
A
S
A
H
L
K
G
G
A
K
K
V
I
I
S
A
P
G
G
-
K
-
D
VD
A
-
T
I
V
Y
G
V
N
H
D
V
L
-
K
-
A
--
E
H
T
--
V
I
S
N
A
S
C
T
T
N
C
L
A
P
L
V
K
P
L
N
D
K
I
G
L
E
T
G
L
M
T
T
I
H
A
Y
T
N
D
Q
V
L
T
D
V
Y
H
--
E
D
L
R
R
A
R
S
A
T
H
S
Q
I
P
T
K
T
G
A
A
A
A
V
G
L
V
L
P
E
L
N
G
K
L
D
G
Y
A
I
R
V
P
T
I
N
V
S
I
V
D
L
S
F
I
A
K
R
D
-
T
T
A
A
E
V
N
A
I
M
K
E
A
S
E
-------
G
A
L
K
G
I
L
G
Y
N
E
A
P
L
V
S
I
D
F
N
H
N
P
A
S
S
-
T
F
D
A
T
L
T
K
V
S
G
R
L
V
K
V
S
S
W
Y
D
N
E
W
G
F
S
N
R
M
L
D
T
A
I
A
L
A
N
A
35
PsiBlast_CBE
93.88
47%
-96
- C4 -
3CMC
4
G3P_GEOSE
P:
[2-330]
--
V
K
V
G
I
N
G
F
G
R
I
G
R
N
V
F
R
--
A
A
---
L
K
--
N
P
---
D
--
I
E
V
V
A
V
N
D
L
-
T
D
A
N
T
L
A
H
L
L
K
Y
D
S
V
H
G
R
L
--
D
-
A
--
E
V
S
V
-
N
G
N
N
L
V
V
N
G
K
E
I
I
V
K
A
E
R
D
P
E
N
L
A
W
G
E
I
G
V
D
I
V
V
E
S
T
G
R
F
T
K
R
E
D
A
A
K
H
L
E
A
G
A
K
K
V
I
I
S
A
P
A
K
-
N
-
E
--
D
I
T
I
V
M
G
V
N
Q
D
K
Y
-
D
-
P
--
K
-
A
HH
V
I
S
N
A
S
C
T
T
N
C
L
A
P
F
A
K
V
L
H
E
Q
F
G
I
V
R
G
M
M
T
T
V
H
S
Y
T
N
D
Q
R
I
L
D
L
P
H
--
K
D
L
R
R
A
R
A
A
A
E
S
I
I
P
T
T
T
G
A
A
K
A
V
A
L
V
L
P
E
L
K
G
K
L
N
G
M
A
M
R
V
P
T
P
N
V
S
V
V
D
L
V
A
E
L
E
K
E
-
V
T
V
E
E
V
N
A
A
L
K
A
A
A
E
-------
G
E
L
K
G
I
L
A
Y
S
E
E
P
L
V
S
R
D
Y
N
G
S
T
V
S
S
T
I
D
A
L
S
T
M
V
I
D
G
K
M
V
K
V
V
S
W
Y
D
N
E
T
G
Y
S
H
R
V
V
D
L
A
A
Y
I
A
S
K
10
PsiBlast_PDB
93.88
47%
-95
- C4 -
1NQ5
2
G3P_GEOSE
O:
[2-330]
--
V
K
V
G
I
N
G
F
G
R
I
G
R
N
V
F
R
--
A
A
---
L
K
--
N
P
---
D
--
I
E
V
V
A
V
N
D
L
-
T
D
A
N
T
L
A
H
L
L
K
Y
D
S
V
H
G
R
L
--
D
-
A
--
E
V
S
V
-
N
G
N
N
L
V
V
N
G
K
E
I
I
V
K
A
E
R
D
P
E
N
L
A
W
G
E
I
G
V
D
I
V
V
E
S
T
G
R
F
T
K
R
E
D
A
A
K
H
L
E
A
G
A
K
K
V
I
I
S
A
P
A
K
-
N
-
E
--
D
I
T
I
V
M
G
V
N
Q
D
K
Y
-
D
-
P
--
K
-
A
HH
V
I
S
N
A
S
S
T
T
N
C
L
A
P
F
A
K
V
L
H
E
Q
F
G
I
V
R
G
M
M
T
T
V
H
S
Y
T
N
D
Q
R
I
L
D
L
P
H
--
K
D
L
R
R
A
R
A
A
A
E
S
I
I
P
T
T
T
G
A
A
K
A
V
A
L
V
L
P
E
L
K
G
K
L
N
G
M
A
M
R
V
P
T
P
N
V
S
V
V
D
L
V
A
E
L
E
K
E
-
V
T
V
E
E
V
N
A
A
L
K
A
A
A
E
-------
G
E
L
K
G
I
L
A
Y
S
E
E
P
L
V
S
R
D
Y
N
G
S
T
V
S
S
T
I
D
A
L
S
T
M
V
I
D
G
K
M
V
K
V
V
S
W
Y
D
N
E
T
G
Y
S
H
R
V
V
D
L
A
A
Y
I
A
S
K
67
PsiBlast_CBE
93.86
45%
-91
- C4 -
3GNQ
2
?
G:
[10-341]
-
T
I
R
V
A
I
N
G
Y
G
R
I
G
R
N
T
L
R
--
A
F
YEN
G
K
--
K
H
---
D
--
L
E
I
V
A
I
N
D
L
-
G
D
A
K
T
N
A
H
L
T
Q
Y
D
T
A
H
G
K
F
--
P
-
G
--
E
V
S
V
-
D
G
D
Y
L
V
V
N
G
D
R
I
R
V
L
A
N
R
N
P
A
E
L
P
W
G
E
L
G
V
D
V
V
M
E
C
T
G
F
F
T
S
K
E
K
A
S
A
H
L
K
G
G
A
K
K
V
I
I
S
A
P
G
G
-
K
-
D
VD
A
-
T
I
V
Y
G
V
N
H
D
V
L
-
K
-
A
--
E
H
T
--
V
I
S
N
A
S
C
T
T
N
C
L
A
P
L
V
K
P
L
N
D
K
I
G
L
E
T
G
L
M
T
T
I
H
A
Y
T
N
D
Q
V
L
T
D
V
Y
H
--
E
D
L
R
R
A
R
S
A
T
H
S
Q
I
P
T
K
T
G
A
A
A
A
V
G
L
V
L
P
E
L
N
G
K
L
D
G
Y
A
I
R
V
P
T
I
N
V
S
I
V
D
L
S
F
I
A
K
R
D
-
T
T
A
A
E
V
N
A
I
M
K
E
A
S
E
-------
G
A
L
K
G
I
L
G
Y
N
E
A
P
L
V
S
I
D
F
N
H
N
P
A
S
S
-
T
F
D
A
T
L
T
K
V
S
G
R
L
V
K
V
S
S
W
Y
D
N
E
W
G
F
S
N
R
M
L
D
T
A
I
A
L
A
N
A
51
PsiBlast_CBE
93.81
47%
-101
- C4 -
1NQ5
2
G3P_GEOSE
Q:
[2-330]
--
V
K
V
G
I
N
G
F
G
R
I
G
R
N
V
F
R
--
A
A
---
L
K
--
N
P
---
D
--
I
E
V
V
A
V
N
D
L
-
T
D
A
N
T
L
A
H
L
L
K
Y
D
S
V
H
G
R
L
--
D
-
A
--
E
V
S
V
-
N
G
N
N
L
V
V
N
G
K
E
I
I
V
K
A
E
R
D
P
E
N
L
A
W
G
E
I
G
V
D
I
V
V
E
S
T
G
R
F
T
K
R
E
D
A
A
K
H
L
E
A
G
A
K
K
V
I
I
S
A
P
A
K
-
N
-
E
--
D
I
T
I
V
M
G
V
N
Q
D
K
Y
-
D
-
P
--
K
-
A
HH
V
I
S
N
A
S
S
T
T
N
C
L
A
P
F
A
K
V
L
H
E
Q
F
G
I
V
R
G
M
M
T
T
V
H
S
Y
T
N
D
Q
R
I
L
D
L
P
H
--
K
D
L
R
R
A
R
A
A
A
E
S
I
I
P
T
T
T
G
A
A
K
A
V
A
L
V
L
P
E
L
K
G
K
L
N
G
M
A
M
R
V
P
T
P
N
V
S
V
V
D
L
V
A
E
L
E
K
E
-
V
T
V
E
E
V
N
A
A
L
K
A
A
A
E
-------
G
E
L
K
G
I
L
A
Y
S
E
E
P
L
V
S
R
D
Y
N
G
S
T
V
S
S
T
I
D
A
L
S
T
M
V
I
D
G
K
M
V
K
V
V
S
W
Y
D
N
E
T
G
Y
S
H
R
V
V
D
L
A
A
Y
I
A
S
K
36
PsiBlast_CBE
93.79
47%
-96
- C4 -
2GD1
2
G3P_GEOSE
R:
[2-330]
--
V
K
V
G
I
N
G
F
G
R
I
G
R
N
V
F
R
--
A
A
---
L
K
--
N
P
---
D
--
I
E
V
V
A
V
N
D
L
-
T
D
A
N
T
L
A
H
L
L
K
Y
D
S
V
H
G
R
L
--
D
-
A
--
E
V
S
V
-
N
G
N
N
L
V
V
N
G
K
E
I
I
V
K
A
E
R
D
P
E
N
L
A
W
G
E
I
G
V
D
I
V
V
E
S
T
G
R
F
T
K
R
E
D
A
A
K
H
L
E
A
G
A
K
K
V
I
I
S
A
P
A
K
-
N
-
E
--
D
I
T
I
V
M
G
V
N
Q
D
K
Y
-
D
-
P
--
K
-
A
HH
V
I
S
N
A
S
C
T
T
N
C
L
A
P
F
A
K
V
L
H
E
Q
F
G
I
V
R
G
M
M
T
T
V
H
S
Y
T
N
D
Q
R
I
L
D
L
P
H
--
K
D
L
R
R
A
R
A
A
A
E
S
I
I
P
T
T
T
G
A
A
K
A
V
A
L
V
L
P
E
L
K
G
K
L
N
G
M
A
M
R
V
P
T
P
N
V
S
V
V
D
L
V
A
E
L
E
K
E
-
V
T
V
E
E
V
N
A
A
L
K
A
A
A
E
-------
G
E
L
K
G
I
L
A
Y
S
E
E
P
L
V
S
R
D
Y
N
G
S
T
V
S
S
T
I
D
A
L
S
T
M
V
I
D
G
K
M
V
K
V
V
S
W
Y
D
N
E
T
G
Y
S
H
R
V
V
D
L
A
A
Y
I
A
S
K
45
PsiBlast_CBE
93.75
47%
-98
- C4 -
1NPT
3
G3P_GEOSE
R:
[2-330]
--
V
K
V
G
I
N
G
F
G
R
I
G
R
N
V
F
R
--
A
A
---
L
K
--
N
P
---
D
--
I
E
V
V
A
V
N
D
L
-
T
D
A
N
T
L
A
H
L
L
K
Y
D
S
V
H
G
R
L
--
D
-
A
--
E
V
S
V
-
N
G
N
N
L
V
V
N
G
K
E
I
I
V
K
A
E
R
D
P
E
N
L
A
W
G
E
I
G
V
D
I
V
V
E
S
T
G
R
F
T
K
R
E
D
A
A
K
H
L
E
A
G
A
K
K
V
I
I
S
A
P
A
K
-
N
-
E
--
D
I
T
I
V
M
G
V
N
Q
D
K
Y
-
D
-
P
--
K
-
A
HH
V
I
S
N
A
S
A
T
T
N
C
L
A
P
F
A
K
V
L
H
E
Q
F
G
I
V
R
G
M
M
T
T
V
H
S
Y
T
N
D
Q
R
I
L
D
L
P
H
--
K
D
L
R
R
A
R
A
A
A
E
S
I
I
P
T
T
T
G
A
A
K
A
V
A
L
V
L
P
E
L
K
G
K
L
N
G
M
A
M
R
V
P
T
P
N
V
S
V
V
D
L
V
A
E
L
E
K
E
-
V
T
V
E
E
V
N
A
A
L
K
A
A
A
E
-------
G
E
L
K
G
I
L
A
Y
S
E
E
P
L
V
S
R
D
Y
N
G
S
T
V
S
S
T
I
D
A
L
S
T
M
V
I
D
G
K
M
V
K
V
V
S
W
Y
D
N
E
T
G
Y
S
H
R
V
V
D
L
A
A
Y
I
A
S
K
112
HHSearch
93.04
43%
-100
- C4 -
1HDG
3
G3P_THEMA
O:
[1-331]
--
A
R
V
A
I
N
G
F
G
R
I
G
R
L
V
Y
R
--
I
I
---
Y
E
RK
N
P
---
D
--
I
E
V
V
A
I
N
D
L
-
T
D
T
K
T
L
A
H
L
L
K
Y
D
S
V
H
K
K
F
PG
K
-
V
--
E
Y
-
T
-
E
N
S
L
I
V
D
-
G
K
E
I
K
V
F
A
E
P
D
P
S
K
L
P
W
K
D
L
G
V
D
F
V
I
E
S
T
G
V
F
R
N
R
E
K
A
E
L
H
L
Q
A
G
A
K
K
V
I
I
T
A
P
A
K
-
G
E
D
--
I
-
T
V
V
I
G
C
N
E
D
Q
L
-
K
P
E
--
H
-
T
--
I
I
S
C
A
S
C
T
T
N
S
I
A
P
I
V
K
V
L
H
E
K
F
G
I
V
S
G
M
L
T
T
V
H
S
Y
T
N
D
Q
R
V
L
D
L
P
H
--
K
D
L
R
R
A
R
A
A
A
V
N
I
I
P
T
T
T
G
A
A
K
A
V
A
L
V
V
P
E
V
K
G
K
L
D
G
M
A
I
R
V
P
T
P
D
G
S
I
T
D
L
T
V
L
V
E
K
E
-
T
T
V
E
E
V
N
A
V
M
K
E
A
T
E
-------
G
R
L
K
G
I
I
G
Y
N
D
E
P
I
V
S
S
D
I
I
G
T
T
F
S
G
I
F
D
A
T
I
T
N
V
I
G
G
K
L
V
K
V
A
S
W
Y
D
N
E
Y
G
Y
S
N
R
V
V
D
T
L
E
L
L
L
K
M
12
PsiBlast_PDB
92.87
45%
-105
- C4 -
3L0D
1
?
A:
[22-354]
M
S
V
R
V
A
I
N
G
F
G
R
I
G
R
N
I
L
R
A
I
I
E
---
S
G
--
R
Q
---
D
--
I
E
V
V
A
L
N
D
L
-
G
S
V
E
T
N
A
H
L
L
R
Y
D
S
V
H
G
C
F
--
P
-
G
--
T
V
Q
V
V
G
D
A
I
D
I
---
L
-
I
K
V
F
A
E
R
D
P
A
Q
L
P
W
K
A
L
D
I
D
I
A
L
E
C
T
G
I
F
T
A
R
D
K
A
S
A
H
L
D
A
G
A
K
R
V
L
V
S
A
P
S
E
-
G
-
A
--
D
L
T
V
V
Y
G
V
N
H
Q
F
L
-
S
-
K
--
E
-
H
H-
V
I
S
N
A
S
C
T
T
N
C
L
A
P
V
A
Q
V
L
H
N
T
V
G
I
E
K
G
F
M
T
T
I
H
S
Y
T
G
D
Q
P
V
L
D
T
M
H
--
R
D
L
Y
R
A
R
A
A
A
L
S
M
I
P
T
S
T
G
A
A
K
A
V
G
L
V
L
P
E
L
K
G
L
L
D
G
V
S
I
R
V
P
T
P
N
V
S
V
V
D
L
T
F
T
A
K
R
S
-
T
T
I
E
E
I
N
T
A
I
R
T
A
A
Q
-------
G
S
L
K
G
I
L
D
Y
T
D
E
K
L
V
S
C
D
F
N
H
N
P
H
S
A
I
F
H
N
D
Q
T
K
V
I
D
G
Q
L
C
R
V
L
V
W
Y
D
N
E
W
G
F
S
N
R
M
C
D
T
A
V
A
F
A
K
T
15
PsiBlast_PDB
92.74
43%
-91
- C4 -
1HDG
3
G3P_THEMA
O:
[2-331]
---
R
V
A
I
N
G
F
G
R
I
G
R
L
V
Y
R
--
I
I
---
Y
E
--
R
K
NP-
D
--
I
E
V
V
A
I
N
D
L
-
T
D
T
K
T
L
A
H
L
L
K
Y
D
S
V
H
K
K
F
--
P
-
G
--
K
V
E
Y
-
T
E
N
S
L
I
V
D
G
K
E
I
K
V
F
A
E
P
D
P
S
K
L
P
W
K
D
L
G
V
D
F
V
I
E
S
T
G
V
F
R
N
R
E
K
A
E
L
H
L
Q
A
G
A
K
K
V
I
I
T
A
P
A
K
-
G
-
E
--
D
I
T
V
V
I
G
C
N
E
D
Q
L
-
K
-
P
--
E
H
T
--
I
I
S
C
A
S
C
T
T
N
S
I
A
P
I
V
K
V
L
H
E
K
F
G
I
V
S
G
M
L
T
T
V
H
S
Y
T
N
D
Q
R
V
L
D
L
P
H
--
K
D
L
R
R
A
R
A
A
A
V
N
I
I
P
T
T
T
G
A
A
K
A
V
A
L
V
V
P
E
V
K
G
K
L
D
G
M
A
I
R
V
P
T
P
D
G
S
I
T
D
L
T
V
L
V
E
K
E
-
T
T
V
E
E
V
N
A
V
M
K
E
A
T
E
-------
G
R
L
K
G
I
I
G
Y
N
D
E
P
I
V
S
S
D
I
I
G
T
T
F
S
G
I
F
D
A
T
I
T
N
V
I
G
G
K
L
V
K
V
A
S
W
Y
D
N
E
Y
G
Y
S
N
R
V
V
D
T
L
E
L
L
L
K
M
62
PsiBlast_CBE
92.67
43%
-94
- C4 -
1HDG
3
G3P_THEMA
Q:
[2-331]
---
R
V
A
I
N
G
F
G
R
I
G
R
L
V
Y
R
--
I
I
---
Y
E
--
R
K
NP-
D
--
I
E
V
V
A
I
N
D
L
-
T
D
T
K
T
L
A
H
L
L
K
Y
D
S
V
H
K
K
F
--
P
-
G
--
K
V
E
Y
-
T
E
N
S
L
I
V
D
G
K
E
I
K
V
F
A
E
P
D
P
S
K
L
P
W
K
D
L
G
V
D
F
V
I
E
S
T
G
V
F
R
N
R
E
K
A
E
L
H
L
Q
A
G
A
K
K
V
I
I
T
A
P
A
K
-
G
-
E
--
D
I
T
V
V
I
G
C
N
E
D
Q
L
-
K
-
P
--
E
H
T
--
I
I
S
C
A
S
C
T
T
N
S
I
A
P
I
V
K
V
L
H
E
K
F
G
I
V
S
G
M
L
T
T
V
H
S
Y
T
N
D
Q
R
V
L
D
L
P
H
--
K
D
L
R
R
A
R
A
A
A
V
N
I
I
P
T
T
T
G
A
A
K
A
V
A
L
V
V
P
E
V
K
G
K
L
D
G
M
A
I
R
V
P
T
P
D
G
S
I
T
D
L
T
V
L
V
E
K
E
-
T
T
V
E
E
V
N
A
V
M
K
E
A
T
E
-------
G
R
L
K
G
I
I
G
Y
N
D
E
P
I
V
S
S
D
I
I
G
T
T
F
S
G
I
F
D
A
T
I
T
N
V
I
G
G
K
L
V
K
V
A
S
W
Y
D
N
E
Y
G
Y
S
N
R
V
V
D
T
L
E
L
L
L
K
M
65
PsiBlast_CBE
92.64
44%
-93
- C4 -
3ZCX
1
?
B:
[19-350]
--
V
R
V
A
I
N
G
F
G
R
I
G
R
N
F
M
R
--
C
W
---
L
Q
--
R
K
ANS
K
--
L
E
I
V
G
I
N
D
T
-
S
D
P
R
T
N
A
H
L
L
K
Y
D
S
M
L
G
I
F
--
Q
D
A
--
E
I
T
A
-
D
D
D
C
I
Y
A
G
G
H
A
V
K
C
V
S
D
R
N
P
E
N
L
P
W
S
A
W
G
I
D
L
V
I
E
A
T
G
V
F
T
S
R
E
G
A
S
K
H
L
S
A
G
A
K
K
V
L
I
T
A
P
G
K
G
N
-
I
--
P
-
T
Y
V
V
G
V
N
H
H
T
Y
-
D
P
S
--
E
-
D
--
I
V
S
N
A
S
C
T
T
N
C
L
A
P
I
V
K
V
L
H
E
A
F
G
I
Q
Q
G
M
M
T
T
T
H
S
Y
T
G
D
Q
R
L
L
D
A
S
H
--
R
D
L
R
R
A
R
A
A
A
M
N
I
V
P
T
S
T
G
A
A
K
A
V
G
L
V
I
P
E
L
Q
G
K
L
N
G
I
A
L
R
V
P
T
P
N
V
S
V
V
D
F
V
A
Q
V
E
K
P
-
T
I
A
E
Q
V
N
Q
V
I
K
E
A
S
E
-------
T
T
M
K
G
I
I
H
Y
S
E
L
E
L
V
S
S
D
Y
R
G
H
N
A
S
S
I
L
D
A
S
L
T
M
V
L
G
G
N
L
V
K
V
V
A
W
Y
D
N
E
W
G
Y
S
Q
R
V
L
D
L
A
E
H
M
A
A
H
54
PsiBlast_CBE
92.48
45%
-101
- C4 -
3L0D
1
?
B:
[22-354]
M
S
V
R
V
A
I
N
G
F
G
R
I
G
R
N
I
L
R
AI
I
E
---
S
G
--
R
Q
---
D
--
I
E
V
V
A
L
N
D
L
-
G
S
V
E
T
N
A
H
L
L
R
Y
D
S
V
H
G
C
F
--
P
-
G
--
T
V
Q
V
V
G
D
A
I
D
I
---
L
-
I
K
V
F
A
E
R
D
P
A
Q
L
P
W
K
A
L
D
I
D
I
A
L
E
C
T
G
I
F
T
A
R
D
K
A
S
A
H
L
D
A
G
A
K
R
V
L
V
S
A
P
S
E
-
G
-
A
--
D
L
T
V
V
Y
G
V
N
H
Q
F
L
-
S
-
K
--
E
-
H
H-
V
I
S
N
A
S
C
T
T
N
C
L
A
P
V
A
Q
V
L
H
N
T
V
G
I
E
K
G
F
M
T
T
I
H
S
Y
T
G
D
Q
P
V
L
D
T
M
H
--
R
D
L
Y
R
A
R
A
A
A
L
S
M
I
P
T
S
T
G
A
A
K
A
V
G
L
V
L
P
E
L
K
G
L
L
D
G
V
S
I
R
V
P
T
P
N
V
S
V
V
D
L
T
F
T
A
K
R
S
-
T
T
I
E
E
I
N
T
A
I
R
T
A
A
Q
-------
G
S
L
K
G
I
L
D
Y
T
D
E
K
L
V
S
C
D
F
N
H
N
P
H
S
A
I
F
H
N
D
Q
T
K
V
I
D
G
Q
L
C
R
V
L
V
W
Y
D
N
E
W
G
F
S
N
R
M
C
D
T
A
V
A
F
A
K
T
63
PsiBlast_CBE
92.32
44%
-93
- C4 -
4BOY
1
?
B:
[19-350]
--
V
R
V
A
I
N
G
F
G
R
I
G
R
N
F
M
R
--
C
W
---
L
Q
--
R
K
ANS
K
--
L
E
I
V
G
I
N
D
T
-
S
D
P
R
T
N
A
H
L
L
K
Y
D
S
M
L
G
I
F
--
Q
D
A
--
E
I
T
A
-
D
D
D
C
I
Y
A
G
G
H
A
V
K
C
V
S
D
R
N
P
E
N
L
P
W
S
A
W
G
I
D
L
V
I
E
A
T
G
V
F
T
S
R
E
G
A
S
K
H
L
S
A
G
A
K
K
V
L
I
T
A
P
G
K
G
N
-
I
--
P
-
T
Y
V
V
G
V
N
H
H
T
Y
-
D
P
S
--
E
-
D
--
I
V
S
N
A
S
C
T
T
N
C
L
A
P
I
V
K
V
L
H
E
A
F
G
I
Q
Q
G
M
M
T
T
T
H
S
Y
T
G
D
Q
R
L
L
D
A
S
H
--
R
D
L
R
R
A
R
A
A
A
M
N
I
V
P
T
S
T
G
A
A
K
A
V
G
L
V
I
P
E
L
Q
G
K
L
N
G
I
A
L
R
V
P
T
P
N
V
S
V
V
D
F
V
A
Q
V
E
K
P
-
T
I
A
E
Q
V
N
Q
V
I
K
E
A
S
E
-------
T
T
M
K
G
I
I
H
Y
S
E
L
E
L
V
S
S
D
Y
R
G
H
N
A
S
S
I
L
D
A
S
L
T
M
V
L
G
G
N
L
V
K
V
V
A
W
Y
D
N
E
W
G
Y
S
Q
R
V
L
D
L
A
E
H
M
A
A
H
18
PsiBlast_PDB
92.21
44%
-94
- C4 -
4BOY
1
?
A:
[19-350]
--
V
R
V
A
I
N
G
F
G
R
I
G
R
N
F
M
R
--
C
W
---
L
Q
--
R
K
ANS
K
--
L
E
I
V
G
I
N
D
T
-
S
D
P
R
T
N
A
H
L
L
K
Y
D
S
M
L
G
I
F
--
Q
D
A
--
E
I
T
A
-
D
D
D
C
I
Y
A
G
G
H
A
V
K
C
V
S
D
R
N
P
E
N
L
P
W
S
A
W
G
I
D
L
V
I
E
A
T
G
V
F
T
S
R
E
G
A
S
K
H
L
S
A
G
A
K
K
V
L
I
T
A
P
G
K
G
N
-
I
--
P
-
T
Y
V
V
G
V
N
H
H
T
Y
-
D
P
S
--
E
-
D
--
I
V
S
N
A
S
C
T
T
N
C
L
A
P
I
V
K
V
L
H
E
A
F
G
I
Q
Q
G
M
M
T
T
T
H
S
Y
T
G
D
Q
R
L
L
D
A
S
H
--
R
D
L
R
R
A
R
A
A
A
M
N
I
V
P
T
S
T
G
A
A
K
A
V
G
L
V
I
P
E
L
Q
G
K
L
N
G
I
A
L
R
V
P
T
P
N
V
S
V
V
D
F
V
A
Q
V
E
K
P
-
T
I
A
E
Q
V
N
Q
V
I
K
E
A
S
E
-------
T
T
M
K
G
I
I
H
Y
S
E
L
E
L
V
S
S
D
Y
R
G
H
N
A
S
S
I
L
D
A
S
L
T
M
V
L
G
G
N
L
V
K
V
V
A
W
Y
D
N
E
W
G
Y
S
Q
R
V
L
D
L
A
E
H
M
A
A
H
64
PsiBlast_CBE
92.13
44%
-95
- C4 -
3ZDF
2
?
B:
[19-350]
--
V
R
V
A
I
N
G
F
G
R
I
G
R
N
F
M
R
--
C
W
---
L
Q
--
R
K
ANS
K
--
L
E
I
V
G
I
N
D
T
-
S
D
P
R
T
N
A
H
L
L
K
Y
D
S
M
L
G
I
F
--
Q
D
A
--
E
I
T
A
-
D
D
D
C
I
Y
A
G
G
H
A
V
K
C
V
S
D
R
N
P
E
N
L
P
W
S
A
W
G
I
D
L
V
I
E
A
T
G
V
F
T
S
R
E
G
A
S
K
H
L
S
A
G
A
K
K
V
L
I
T
A
P
G
K
G
N
-
I
--
P
-
T
Y
V
V
G
V
N
H
H
T
Y
-
D
P
S
--
E
-
D
--
I
V
S
N
A
S
C
T
T
N
C
L
A
P
I
V
K
V
L
H
E
A
F
G
I
Q
Q
G
M
M
T
T
T
H
S
Y
T
G
D
Q
R
L
L
D
A
S
H
--
R
D
L
R
R
A
R
A
A
A
M
N
I
V
P
T
S
T
G
A
A
K
A
V
G
L
V
I
P
E
L
Q
G
K
L
N
G
I
A
L
R
V
P
T
P
N
V
S
V
V
D
F
V
A
Q
V
E
K
P
-
T
I
A
E
Q
V
N
Q
V
I
K
E
A
S
E
-------
T
T
M
K
G
I
I
H
Y
S
E
L
E
L
V
S
S
D
Y
R
G
H
N
A
S
S
I
L
D
A
S
L
T
M
V
L
G
G
N
L
V
K
V
V
A
W
Y
D
N
E
W
G
Y
S
Q
R
V
L
D
L
A
E
H
M
A
A
H
16
PsiBlast_PDB
92.01
44%
-92
- C4 -
3ZCX
1
?
A:
[19-350]
--
V
R
V
A
I
N
G
F
G
R
I
G
R
N
F
M
R
--
C
W
---
L
Q
--
R
K
ANS
K
--
L
E
I
V
G
I
N
D
T
-
S
D
P
R
T
N
A
H
L
L
K
Y
D
S
M
L
G
I
F
--
Q
D
A
--
E
I
T
A
-
D
D
D
C
I
Y
A
G
G
H
A
V
K
C
V
S
D
R
N
P
E
N
L
P
W
S
A
W
G
I
D
L
V
I
E
A
T
G
V
F
T
S
R
E
G
A
S
K
H
L
S
A
G
A
K
K
V
L
I
T
A
P
G
K
G
N
-
I
--
P
-
T
Y
V
V
G
V
N
H
H
T
Y
-
D
P
S
--
E
-
D
--
I
V
S
N
A
S
C
T
T
N
C
L
A
P
I
V
K
V
L
H
E
A
F
G
I
Q
Q
G
M
M
T
T
T
H
S
Y
T
G
D
Q
R
L
L
D
A
S
H
--
R
D
L
R
R
A
R
A
A
A
M
N
I
V
P
T
S
T
G
A
A
K
A
V
G
L
V
I
P
E
L
Q
G
K
L
N
G
I
A
L
R
V
P
T
P
N
V
S
V
V
D
F
V
A
Q
V
E
K
P
-
T
I
A
E
Q
V
N
Q
V
I
K
E
A
S
E
-------
T
T
M
K
G
I
I
H
Y
S
E
L
E
L
V
S
S
D
Y
R
G
H
N
A
S
S
I
L
D
A
S
L
T
M
V
L
G
G
N
L
V
K
V
V
A
W
Y
D
N
E
W
G
Y
S
Q
R
V
L
D
L
A
E
H
M
A
A
H
17
PsiBlast_PDB
91.85
44%
-94
- C4 -
3ZDF
2
?
A:
[19-350]
--
V
R
V
A
I
N
G
F
G
R
I
G
R
N
F
M
R
--
C
W
---
L
Q
--
R
K
ANS
K
--
L
E
I
V
G
I
N
D
T
-
S
D
P
R
T
N
A
H
L
L
K
Y
D
S
M
L
G
I
F
--
Q
D
A
--
E
I
T
A
-
D
D
D
C
I
Y
A
G
G
H
A
V
K
C
V
S
D
R
N
P
E
N
L
P
W
S
A
W
G
I
D
L
V
I
E
A
T
G
V
F
T
S
R
E
G
A
S
K
H
L
S
A
G
A
K
K
V
L
I
T
A
P
G
K
G
N
-
I
--
P
-
T
Y
V
V
G
V
N
H
H
T
Y
-
D
P
S
--
E
-
D
--
I
V
S
N
A
S
C
T
T
N
C
L
A
P
I
V
K
V
L
H
E
A
F
G
I
Q
Q
G
M
M
T
T
T
H
S
Y
T
G
D
Q
R
L
L
D
A
S
H
--
R
D
L
R
R
A
R
A
A
A
M
N
I
V
P
T
S
T
G
A
A
K
A
V
G
L
V
I
P
E
L
Q
G
K
L
N
G
I
A
L
R
V
P
T
P
N
V
S
V
V
D
F
V
A
Q
V
E
K
P
-
T
I
A
E
Q
V
N
Q
V
I
K
E
A
S
E
-------
T
T
M
K
G
I
I
H
Y
S
E
L
E
L
V
S
S
D
Y
R
G
H
N
A
S
S
I
L
D
A
S
L
T
M
V
L
G
G
N
L
V
K
V
V
A
W
Y
D
N
E
W
G
Y
S
Q
R
V
L
D
L
A
E
H
M
A
A
H
116
HHSearch
91.41
44%
-92
- C4 -
2EP7
1
G3P_AQUAE
A:
[3-339]
--
I
K
V
G
I
N
G
F
G
R
I
G
R
S
F
F
R
--
A
S
---
W
G
--
R
E
---
E
--
I
E
I
V
A
I
N
D
L
-
T
D
A
K
H
L
A
H
L
L
K
Y
D
S
V
H
G
I
F
K
G
S
-
V
--
E
A
-
K
-
D
D
S
I
V
V
D
-
G
K
E
I
K
V
F
A
Q
K
D
P
S
Q
I
P
W
G
D
L
G
V
D
V
V
I
E
A
T
G
V
F
R
D
R
E
N
A
S
K
H
L
Q
G
G
A
K
K
V
I
I
T
A
P
A
K
-
N
P
D
--
I
-
T
V
V
L
G
V
N
E
E
K
Y
-
N
-
P
KE
H
-
N
--
I
I
S
N
A
S
C
T
T
N
C
L
A
P
C
V
K
V
L
N
E
A
F
G
V
E
K
G
Y
M
V
T
V
H
A
Y
T
N
D
Q
R
L
L
D
L
P
H
--
K
D
F
R
R
A
R
A
A
A
I
N
I
V
P
T
T
T
G
A
A
K
A
I
G
E
V
I
P
E
L
K
G
K
L
D
G
T
A
R
R
V
P
V
P
D
G
S
L
I
D
L
T
V
V
V
N
K
A
P
S
S
V
E
E
V
N
E
K
F
R
E
A
A
Q
K
Y
R
E
SGK
V
Y
L
K
E
I
L
Q
Y
C
E
D
P
I
V
S
T
D
I
V
G
N
P
H
S
A
I
F
D
A
P
L
T
Q
V
-
I
D
N
L
V
H
I
A
A
W
Y
D
N
E
W
G
Y
S
C
R
L
R
D
L
V
I
Y
L
A
E
R
113
HHSearch
91.37
42%
-101
- C4 -
3CPS
1
?
A:
[18-352]
--
G
T
L
G
I
N
G
F
G
R
I
G
R
L
V
L
R
--
A
C
---
M
E
--
R
N
---
D
--
I
T
V
V
A
I
N
D
P
F
M
D
V
E
Y
M
A
Y
L
L
K
Y
D
S
V
H
G
N
F
N
G
T
-
V
--
E
V
-
S
-
G
-
D
L
C
I
N
-
G
K
V
V
K
V
F
Q
A
K
D
P
A
E
I
P
W
G
A
S
G
A
Q
I
V
C
E
S
T
G
V
F
T
T
E
E
K
A
S
L
H
L
K
G
G
A
K
K
V
I
I
S
A
P
P
K
-
D
N
V
--
P
-
M
Y
V
M
G
V
N
N
T
E
Y
-
D
-
P
SK
F
-
N
--
V
I
S
N
A
S
C
T
T
N
C
L
A
P
L
A
K
I
I
N
D
K
F
G
I
V
E
G
L
M
T
T
V
H
S
L
T
A
N
Q
L
T
V
D
G
P
S
KG-
D
W
R
A
G
R
C
A
G
N
N
I
I
P
A
S
T
G
A
A
K
A
V
G
K
V
I
P
A
L
N
G
K
L
T
G
M
A
I
R
V
P
T
P
D
V
S
V
V
D
L
T
C
K
L
A
K
P
-
A
S
I
E
E
I
Y
Q
A
V
K
E
A
S
N
-------
G
P
M
K
G
I
M
G
Y
T
S
D
D
V
V
S
T
D
F
I
G
C
K
Y
S
S
I
F
D
K
N
A
C
I
A
L
N
D
S
F
V
K
L
I
S
W
Y
D
N
E
S
G
Y
S
N
R
L
V
D
L
A
V
Y
V
A
S
R
115
HHSearch
91.16
40%
-103
- C4 -
3PYM
3
G3P3_YEAST
A:
[1-331]
-
M
V
R
V
A
I
N
G
F
G
R
I
G
R
L
V
M
R
--
I
A
---
L
S
--
R
P
---
N
--
V
E
V
V
A
L
N
D
P
F
I
T
N
D
Y
A
A
Y
M
F
K
Y
D
S
T
H
G
R
Y
A
G
E
-
V
--
S
H
-
D
-
D
K
H
I
I
V
D
-
G
K
K
I
A
T
Y
Q
E
R
D
P
A
N
L
P
W
G
S
S
N
V
D
I
A
I
D
S
T
G
V
F
K
E
L
D
T
A
Q
K
H
I
D
A
G
A
K
K
V
V
I
T
A
P
S
S
-
T
-
A
--
P
-
M
F
V
M
G
V
N
E
E
K
Y
-
T
S
D
--
L
-
K
--
I
V
S
N
A
S
C
T
T
N
C
L
A
P
L
A
K
V
I
N
D
A
F
G
I
E
E
G
L
M
T
T
V
H
S
L
T
A
T
Q
K
T
V
D
G
P
S
H-
K
D
W
R
G
G
R
T
A
S
G
N
I
I
P
S
S
T
G
A
A
K
A
V
G
K
V
L
P
E
L
Q
G
K
L
T
G
M
A
F
R
V
P
T
V
D
V
S
V
V
D
L
T
V
K
L
N
K
E
-
T
T
Y
D
E
I
K
K
V
V
K
A
A
A
E
-------
G
K
L
K
G
V
L
G
Y
T
E
D
A
V
V
S
S
D
F
L
G
D
S
H
S
S
I
F
D
A
S
A
G
I
Q
L
S
P
K
F
V
K
L
V
S
W
Y
D
N
E
Y
G
Y
S
T
R
V
V
D
L
V
E
H
V
A
K
A
77
PsiBlast_CBE
90.71
43%
-100
- C4 -
1RM4
3
G3PA_SPIOL
O:
[2-332]
--
L
K
V
A
I
N
G
F
G
R
I
G
R
N
F
L
R
--
C
W
---
H
G
--
R
K
---
D
SP
L
D
V
V
V
I
N
D
T
-
G
G
V
K
Q
A
S
H
L
L
K
Y
D
S
I
L
G
T
F
--
D
-
A
DV
K
T
A
G
-
D
S
A
I
S
V
-
D
G
K
V
I
K
V
V
S
D
R
N
P
V
N
L
P
W
G
D
M
G
I
D
L
V
I
E
G
T
G
V
F
V
D
R
D
G
A
G
K
H
L
Q
A
G
A
K
K
V
L
I
T
A
P
G
K
G
D
-
I
--
P
-
T
Y
V
V
G
V
N
E
E
G
Y
T
H
-
A
--
D
-
T
--
I
I
S
N
A
S
C
T
T
N
C
L
A
P
F
V
K
V
L
D
Q
K
F
G
I
I
K
G
T
M
T
T
T
H
S
Y
T
G
D
Q
R
L
L
D
A
S
H
--
R
D
L
R
R
A
R
A
A
C
L
N
I
V
P
T
S
T
G
A
A
K
A
V
A
L
V
L
P
N
L
K
G
K
L
N
G
I
A
L
R
V
P
T
P
N
V
S
V
V
D
L
V
V
Q
V
S
K
K
-
T
F
A
E
E
V
N
A
A
F
R
E
S
A
D
-------
N
E
L
K
G
I
L
S
V
C
D
E
P
L
V
S
I
D
F
R
C
T
D
V
S
S
T
I
D
S
S
L
T
M
V
M
G
D
D
M
V
K
V
I
A
W
Y
D
N
E
W
G
Y
S
Q
R
V
V
D
L
A
D
I
V
A
N
K
78
PsiBlast_CBE
90.63
43%
-101
- C4 -
1RM4
5
G3PA_SPIOL
B:
[2-332]
--
L
K
V
A
I
N
G
F
G
R
I
G
R
N
F
L
R
--
C
W
---
H
G
--
R
K
---
D
SP
L
D
V
V
V
I
N
D
T
-
G
G
V
K
Q
A
S
H
L
L
K
Y
D
S
I
L
G
T
F
--
D
-
A
DV
K
T
A
G
-
D
S
A
I
S
V
-
D
G
K
V
I
K
V
V
S
D
R
N
P
V
N
L
P
W
G
D
M
G
I
D
L
V
I
E
G
T
G
V
F
V
D
R
D
G
A
G
K
H
L
Q
A
G
A
K
K
V
L
I
T
A
P
G
K
G
D
-
I
--
P
-
T
Y
V
V
G
V
N
E
E
G
Y
T
H
-
A
--
D
-
T
--
I
I
S
N
A
S
C
T
T
N
C
L
A
P
F
V
K
V
L
D
Q
K
F
G
I
I
K
G
T
M
T
T
T
H
S
Y
T
G
D
Q
R
L
L
D
A
S
H
--
R
D
L
R
R
A
R
A
A
C
L
N
I
V
P
T
S
T
G
A
A
K
A
V
A
L
V
L
P
N
L
K
G
K
L
N
G
I
A
L
R
V
P
T
P
N
V
S
V
V
D
L
V
V
Q
V
S
K
K
-
T
F
A
E
E
V
N
A
A
F
R
E
S
A
D
-------
N
E
L
K
G
I
L
S
V
C
D
E
P
L
V
S
I
D
F
R
C
T
D
V
S
S
T
I
D
S
S
L
T
M
V
M
G
D
D
M
V
K
V
I
A
W
Y
D
N
E
W
G
Y
S
Q
R
V
V
D
L
A
D
I
V
A
N
K
108
HHSearch
90.46
44%
-98
- C4 -
1RM4
3
G3PA_SPIOL
O:
[1-334]
-
K
L
K
V
A
I
N
G
F
G
R
I
G
R
N
F
L
R
--
C
W
---
H
G
--
R
K
DS-
P
--
L
D
V
V
V
I
N
D
T
-
G
G
V
K
Q
A
S
H
L
L
K
Y
D
S
I
L
G
T
F
DA
D
-
V
--
K
T
A
G
-
D
S
A
I
S
V
D
-
G
K
V
I
K
V
V
S
D
R
N
P
V
N
L
P
W
G
D
M
G
I
D
L
V
I
E
G
T
G
V
F
V
D
R
D
G
A
G
K
H
L
Q
A
G
A
K
K
V
L
I
T
A
P
G
K
-
G
D
I
--
P
-
T
Y
V
V
G
V
N
E
E
G
Y
-
T
-
H
A-
D
-
T
--
I
I
S
N
A
S
C
T
T
N
C
L
A
P
F
V
K
V
L
D
Q
K
F
G
I
I
K
G
T
M
T
T
T
H
S
Y
T
G
D
Q
R
L
L
D
A
S
H
--
R
D
L
R
R
A
R
A
A
C
L
N
I
V
P
T
S
T
G
A
A
K
A
V
A
L
V
L
P
N
L
K
G
K
L
N
G
I
A
L
R
V
P
T
P
N
V
S
V
V
D
L
V
V
Q
V
S
K
K
-
T
F
A
E
E
V
N
A
A
F
R
E
S
A
D
-------
N
E
L
K
G
I
L
S
V
C
D
E
P
L
V
S
I
D
F
R
C
T
D
V
S
S
T
I
D
S
S
L
T
M
V
M
G
D
D
M
V
K
V
I
A
W
Y
D
N
E
W
G
Y
S
Q
R
V
V
D
L
A
D
I
V
A
N
K
94
PsiBlast_CBE
90.42
43%
-103
- C4 -
1RM5
4
G3PA_SPIOL
O:
[2-332]
--
L
K
V
A
I
N
G
F
G
R
I
G
R
N
F
L
R
--
C
W
---
H
G
--
R
K
---
D
SP
L
D
V
V
V
I
N
D
T
-
G
G
V
K
Q
A
S
H
L
L
K
Y
D
S
I
L
G
T
F
--
D
-
A
DV
K
T
A
G
-
D
S
A
I
S
V
-
D
G
K
V
I
K
V
V
S
D
R
N
P
V
N
L
P
W
G
D
M
G
I
D
L
V
I
E
G
T
G
V
F
V
D
R
D
G
A
G
K
H
L
Q
A
G
A
K
K
V
L
I
T
A
P
G
K
G
D
-
I
--
P
-
T
Y
V
V
G
V
N
E
E
G
Y
T
H
-
A
--
D
-
T
--
I
I
S
N
A
S
C
T
T
N
C
L
A
P
F
V
K
V
L
D
Q
K
F
G
I
I
K
G
T
M
T
T
T
H
S
Y
T
G
D
Q
R
L
L
D
A
A
H
--
R
D
L
R
R
A
R
A
A
C
L
N
I
V
P
T
S
T
G
A
A
K
A
V
A
L
V
L
P
N
L
K
G
K
L
N
G
I
A
L
R
V
P
T
P
N
V
S
V
V
D
L
V
V
Q
V
S
K
K
-
T
F
A
E
E
V
N
A
A
F
R
E
S
A
D
-------
N
E
L
K
G
I
L
S
V
C
D
E
P
L
V
S
I
D
F
R
C
T
D
V
S
S
T
I
D
S
S
L
T
M
V
M
G
D
D
M
V
K
V
I
A
W
Y
D
N
E
W
G
Y
S
Q
R
V
V
D
L
A
D
I
V
A
N
K
79
PsiBlast_CBE
90.37
43%
-100
- C4 -
1RM4
6
G3PA_SPIOL
A:
[2-332]
--
L
K
V
A
I
N
G
F
G
R
I
G
R
N
F
L
R
--
C
W
---
H
G
--
R
K
---
D
SP
L
D
V
V
V
I
N
D
T
-
G
G
V
K
Q
A
S
H
L
L
K
Y
D
S
I
L
G
T
F
--
D
-
A
D
V
K
T
A
G
-
D
S
A
I
S
V
-
D
G
K
V
I
K
V
V
S
D
R
N
P
V
N
L
P
W
G
D
M
G
I
D
L
V
I
E
G
T
G
V
F
V
D
R
D
G
A
G
K
H
L
Q
A
G
A
K
K
V
L
I
T
A
P
G
K
G
D
-
I
--
P
-
T
Y
V
V
G
V
N
E
E
G
Y
T
H
-
A
--
D
-
T
--
I
I
S
N
A
S
C
T
T
N
C
L
A
P
F
V
K
V
L
D
Q
K
F
G
I
I
K
G
T
M
T
T
T
H
S
Y
T
G
D
Q
R
L
L
D
A
S
H
--
R
D
L
R
R
A
R
A
A
C
L
N
I
V
P
T
S
T
G
A
A
K
A
V
A
L
V
L
P
N
L
K
G
K
L
N
G
I
A
L
R
V
P
T
P
N
V
S
V
V
D
L
V
V
Q
V
S
K
K
-
T
F
A
E
E
V
N
A
A
F
R
E
S
A
D
-------
N
E
L
K
G
I
L
S
V
C
D
E
P
L
V
S
I
D
F
R
C
T
D
V
S
S
T
I
D
S
S
L
T
M
V
M
G
D
D
M
V
K
V
I
A
W
Y
D
N
E
W
G
Y
S
Q
R
V
V
D
L
A
D
I
V
A
N
K
95
PsiBlast_CBE
90.36
43%
-102
- C4 -
1RM5
5
G3PA_SPIOL
B:
[2-332]
--
L
K
V
A
I
N
G
F
G
R
I
G
R
N
F
L
R
--
C
W
---
H
G
--
R
K
---
D
SP
L
D
V
V
V
I
N
D
T
-
G
G
V
K
Q
A
S
H
L
L
K
Y
D
S
I
L
G
T
F
--
D
-
A
DV
K
T
A
G
-
D
S
A
I
S
V
-
D
G
K
V
I
K
V
V
S
D
R
N
P
V
N
L
P
W
G
D
M
G
I
D
L
V
I
E
G
T
G
V
F
V
D
R
D
G
A
G
K
H
L
Q
A
G
A
K
K
V
L
I
T
A
P
G
K
G
D
-
I
--
P
-
T
Y
V
V
G
V
N
E
E
G
Y
T
H
-
A
--
D
-
T
--
I
I
S
N
A
S
C
T
T
N
C
L
A
P
F
V
K
V
L
D
Q
K
F
G
I
I
K
G
T
M
T
T
T
H
S
Y
T
G
D
Q
R
L
L
D
A
A
H
--
R
D
L
R
R
A
R
A
A
C
L
N
I
V
P
T
S
T
G
A
A
K
A
V
A
L
V
L
P
N
L
K
G
K
L
N
G
I
A
L
R
V
P
T
P
N
V
S
V
V
D
L
V
V
Q
V
S
K
K
-
T
F
A
E
E
V
N
A
A
F
R
E
S
A
D
-------
N
E
L
K
G
I
L
S
V
C
D
E
P
L
V
S
I
D
F
R
C
T
D
V
S
S
T
I
D
S
S
L
T
M
V
M
G
D
D
M
V
K
V
I
A
W
Y
D
N
E
W
G
Y
S
Q
R
V
V
D
L
A
D
I
V
A
N
K
80
PsiBlast_CBE
90.30
43%
-101
- C4 -
1NBO
4
G3PA_SPIOL
B:
[2-332]
--
L
K
V
A
I
N
G
F
G
R
I
G
R
N
F
L
R
--
C
W
---
H
G
--
R
K
---
D
SP
L
D
V
V
V
I
N
D
T
-
G
G
V
K
Q
A
S
H
L
L
K
Y
D
S
I
L
G
T
F
--
D
-
A
DV
K
T
A
G
-
D
S
A
I
S
V
-
D
G
K
V
I
K
V
V
S
D
R
N
P
V
N
L
P
W
G
D
M
G
I
D
L
V
I
E
G
T
G
V
F
V
D
R
D
G
A
G
K
H
L
Q
A
G
A
K
K
V
L
I
T
A
P
G
K
G
D
-
I
--
P
-
T
Y
V
V
G
V
N
E
E
G
Y
T
H
-
A
--
D
-
T
--
I
I
S
N
A
S
C
T
T
N
C
L
A
P
F
V
K
V
L
D
Q
K
F
G
I
I
K
G
T
M
T
T
T
H
S
Y
T
G
D
Q
R
L
L
D
A
S
H
--
R
D
L
R
R
A
R
A
A
C
L
N
I
V
P
T
S
T
G
A
A
K
A
V
A
L
V
L
P
N
L
K
G
K
L
N
G
I
A
L
R
V
P
T
P
N
V
S
V
V
D
L
V
V
Q
V
S
K
K
-
T
F
A
E
E
V
N
A
A
F
R
E
S
A
D
-------
N
E
L
K
G
I
L
S
V
C
D
E
P
L
V
S
I
D
F
R
C
T
D
V
S
S
T
I
D
S
S
L
T
M
V
M
G
D
D
M
V
K
V
I
A
W
Y
D
N
E
W
G
Y
S
Q
R
V
V
D
L
A
D
I
V
A
N
K
81
PsiBlast_CBE
90.17
43%
-100
- C4 -
1NBO
4
G3PA_SPIOL
A:
[2-332]
--
L
K
V
A
I
N
G
F
G
R
I
G
R
N
F
L
R
--
C
W
---
H
G
--
R
K
---
D
SP
L
D
V
V
V
I
N
D
T
-
G
G
V
K
Q
A
S
H
L
L
K
Y
D
S
I
L
G
T
F
--
D
-
A
D
V
K
T
A
G
-
D
S
A
I
S
V
-
D
G
K
V
I
K
V
V
S
D
R
N
P
V
N
L
P
W
G
D
M
G
I
D
L
V
I
E
G
T
G
V
F
V
D
R
D
G
A
G
K
H
L
Q
A
G
A
K
K
V
L
I
T
A
P
G
K
G
D
-
I
--
P
-
T
Y
V
V
G
V
N
E
E
G
Y
T
H
-
A
--
D
-
T
--
I
I
S
N
A
S
C
T
T
N
C
L
A
P
F
V
K
V
L
D
Q
K
F
G
I
I
K
G
T
M
T
T
T
H
S
Y
T
G
D
Q
R
L
L
D
A
S
H
--
R
D
L
R
R
A
R
A
A
C
L
N
I
V
P
T
S
T
G
A
A
K
A
V
A
L
V
L
P
N
L
K
G
K
L
N
G
I
A
L
R
V
P
T
P
N
V
S
V
V
D
L
V
V
Q
V
S
K
K
-
T
F
A
E
E
V
N
A
A
F
R
E
S
A
D
-------
N
E
L
K
G
I
L
S
V
C
D
E
P
L
V
S
I
D
F
R
C
T
D
V
S
S
T
I
D
S
S
L
T
M
V
M
G
D
D
M
V
K
V
I
A
W
Y
D
N
E
W
G
Y
S
Q
R
V
V
D
L
A
D
I
V
A
N
K
96
PsiBlast_CBE
90.06
43%
-102
- C4 -
1RM5
5
G3PA_SPIOL
A:
[2-332]
--
L
K
V
A
I
N
G
F
G
R
I
G
R
N
F
L
R
--
C
W
---
H
G
--
R
K
---
D
SP
L
D
V
V
V
I
N
D
T
-
G
G
V
K
Q
A
S
H
L
L
K
Y
D
S
I
L
G
T
F
--
D
-
A
D
V
K
T
A
G
-
D
S
A
I
S
V
-
D
G
K
V
I
K
V
V
S
D
R
N
P
V
N
L
P
W
G
D
M
G
I
D
L
V
I
E
G
T
G
V
F
V
D
R
D
G
A
G
K
H
L
Q
A
G
A
K
K
V
L
I
T
A
P
G
K
G
D
-
I
--
P
-
T
Y
V
V
G
V
N
E
E
G
Y
T
H
-
A
--
D
-
T
--
I
I
S
N
A
S
C
T
T
N
C
L
A
P
F
V
K
V
L
D
Q
K
F
G
I
I
K
G
T
M
T
T
T
H
S
Y
T
G
D
Q
R
L
L
D
A
A
H
--
R
D
L
R
R
A
R
A
A
C
L
N
I
V
P
T
S
T
G
A
A
K
A
V
A
L
V
L
P
N
L
K
G
K
L
N
G
I
A
L
R
V
P
T
P
N
V
S
V
V
D
L
V
V
Q
V
S
K
K
-
T
F
A
E
E
V
N
A
A
F
R
E
S
A
D
-------
N
E
L
K
G
I
L
S
V
C
D
E
P
L
V
S
I
D
F
R
C
T
D
V
S
S
T
I
D
S
S
L
T
M
V
M
G
D
D
M
V
K
V
I
A
W
Y
D
N
E
W
G
Y
S
Q
R
V
V
D
L
A
D
I
V
A
N
K
20
PsiBlast_PDB
89.93
43%
-98
- C4 -
1NBO
3
G3PA_SPIOL
O:
[2-332]
--
L
K
V
A
I
N
G
F
G
R
I
G
R
N
F
L
R
--
C
W
---
H
G
--
R
K
---
D
SP
L
D
V
V
V
I
N
D
T
-
G
G
V
K
Q
A
S
H
L
L
K
Y
D
S
I
L
G
T
F
--
D
-
A
DV
K
T
A
G
-
D
S
A
I
S
V
-
D
G
K
V
I
K
V
V
S
D
R
N
P
V
N
L
P
W
G
D
M
G
I
D
L
V
I
E
G
T
G
V
F
V
D
R
D
G
A
G
K
H
L
Q
A
G
A
K
K
V
L
I
T
A
P
G
K
G
D
-
I
--
P
-
T
Y
V
V
G
V
N
E
E
G
Y
T
H
-
A
--
D
-
T
--
I
I
S
N
A
S
C
T
T
N
C
L
A
P
F
V
K
V
L
D
Q
K
F
G
I
I
K
G
T
M
T
T
T
H
S
Y
T
G
D
Q
R
L
L
D
A
S
H
--
R
D
L
R
R
A
R
A
A
C
L
N
I
V
P
T
S
T
G
A
A
K
A
V
A
L
V
L
P
N
L
K
G
K
L
N
G
I
A
L
R
V
P
T
P
N
V
S
V
V
D
L
V
V
Q
V
S
K
K
-
T
F
A
E
E
V
N
A
A
F
R
E
S
A
D
-------
N
E
L
K
G
I
L
S
V
C
D
E
P
L
V
S
I
D
F
R
C
T
D
V
S
S
T
I
D
S
S
L
T
M
V
M
G
D
D
M
V
K
V
I
A
W
Y
D
N
E
W
G
Y
S
Q
R
V
V
D
L
A
D
I
V
A
N
K
119
HHSearch
87.71
36%
-101
- C4 -
3H9E
10
G3PT_HUMAN
O:
[6-337]
R
E
L
T
V
G
I
N
G
F
G
R
I
G
R
L
V
L
R
--
A
C
---
M
E
--
K
----
G
--
V
K
V
V
A
V
N
D
P
F
I
D
P
E
Y
M
V
Y
M
F
K
Y
D
S
T
H
G
R
Y
KG
S
-
V
--
E
F
-
R
-
N
G
Q
L
V
V
D
-
N
H
E
I
S
V
Y
Q
C
K
E
P
K
Q
I
P
W
R
A
V
G
S
P
Y
V
V
E
S
T
G
V
Y
L
S
I
Q
A
A
S
D
H
I
S
A
G
A
Q
R
V
V
I
S
A
P
S
P
-
D
-
A
--
P
-
M
F
V
M
G
V
N
E
N
D
Y
-
N
-
P
GS
M
-
N
--
I
V
S
N
A
S
C
T
T
N
C
L
A
P
L
A
K
V
I
H
E
R
F
G
I
V
E
G
L
M
T
T
V
H
S
Y
T
A
T
Q
K
T
V
D
G
P
S
R-
K
A
W
R
D
G
R
G
A
H
Q
N
I
I
P
A
S
T
G
A
A
K
A
V
T
K
V
I
P
E
L
K
G
K
L
T
G
M
A
F
R
V
P
T
P
D
V
S
V
V
D
L
T
C
R
L
A
Q
P
-
A
P
Y
S
A
I
K
E
A
V
K
A
A
A
K
-------
G
P
M
A
G
I
L
A
Y
T
E
D
E
V
V
S
T
D
F
L
G
D
T
H
S
S
I
F
D
A
K
A
G
I
A
L
N
D
N
F
V
K
L
I
S
W
Y
D
N
E
Y
G
Y
S
H
R
V
V
D
L
L
R
Y
M
F
S
R