@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_1268: (2015-12-22 )
MGFLFEKSLMGFCAHSIKIIKVTGLILSFLAAFLVAEDTHEPEEIKAKVAYVKIPQLEDLENTPVYIGQTIGVTYDLLLFDAEFLEAKIKDGWDKTQIELLNKMPKWKKVEKELFRATYYYKIKGIRASIPSLEVSAFSNKDKYIDHSIAPKVALQVTDLSKNPRYANVMAKDLQVVQYKTKDYDDKNNILVMELAFKEANWEDFHVKEAIKQGFDNASLNQIKAKEGSVFYYCVLPKTLQNLSFDYFSLSNRQFKTLSFSAIPTQDTTGIQSDLIPKNNFLVFSNVALLALCVFFLALFFIFGRKLIFLGLGILCLGFVLYNLLFTQKSALLLAHKKIRILPTQNSTILGLSRDEMPIKILGSHDDYYKILTPHEQIGWVKKDEVK
Atome Classification :
(20 SA)
-----------------------------------------------------------.........10........20........30........40.--..---.....50...---..-...60........70...---------------.....-----80........90........100....--...--------110.-----......----------120.......130---------.......-------------------.140----.......-150.......160------....----------.------..170--........---.180.------------.....----.----190...--....200--......----------...210....----...220.......230.--------......------240----.........250..-.---------....260.......270........-------.--280.......290------------------......----...300--.......310....----...320----------....--...330..---.....---340.----..----------------....--------350..--.....--360-----..--.--...---.370..--.....380.....-----------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-----------------------------------------------------------M
G
F
L
F
E
K
S
L
M
G
F
C
AH
S
I
K
I
I
K
V
T
G
L
I
L
S
F
L
A
A
F
L
VAEDTH
E
P
--
E
E
---
I
K
A
K
V
A
Y
V
KI---PQ-LEDLENT
P
V
Y
I
G
Q
TI
G
V
T
---------------
Y
D
L
L
L
-----F
D
A
E
F
L
E
A
K
I
KDGW
D
K
T
Q
I
E
L
L
NKMP
K
--
W
K
K
--------
V
E
K
E
-----
L
F
R
A
T
Y
----------
Y
Y
K
I
KGIRASIP----------
S
L
E
V
S
AF-------------------SNKD----KYIDHSI-A
P
K
V
A
L
Q
V
TDLSK------NP
R
Y
----------
A
------
N
V
M
----
A
KD
L
Q
V
V
Q
---
Y
KTKD------------YDDKN----
N
----
I
L
V
M
E
L
--
A
FKEA----NWED
F
H
----------
V
K
E
A
I
K
QGFD----NASLN
Q
I
KAKEG
S
V
F
Y
Y
--------
C
V
L
P
K
T
------
L
------
Q
NLS
F
D
Y
FSLSN
R
Q
-
F
---------
K
T
L
S
F
SAIPTQDTTG--IQSDLIPK-------N--
N
F
L
V
F
S
N
V
A
L
L
--------------------
A
L
C
V
F
F
----
L
A
L
F
F
I
--FG
R
K
L
I
F
L
G
L
G
I
L
C
----
L
G
F
V
L
Y
----------
N
L
L
F--TQKS
A
L
L
L
---AH
K
K
I
---
R
I
L
P----TQ----------------N
S
T
I
--------
L
G
LSR--DEM
P
I
--
K
I
L-----GS--H--D
D
Y
---
Y
K
ILTP--
H
E
QIG
W
V
KKDEVK-----------------
47
Fugue
74.08
17%
-33
- C2 -
4ZFV
4
?
A:
[10-445]
----------------------------------------------------N
V
L
D
F
T
V
L
G
L
N
S
G
T
S
M
D
G
I
D
C
A
L
C
H
F
Y
Q
K
T
P
---
D
A
P
M
E
F
E
L
L
E
Y
G
E
V
P
LA
Q
P
---
I
K
Q
R
V
M
R
M
I
L
E
DT
T
S
-
P
S
E
L
S
E
V
N
V
I
L
G
E
H
F
A
D
A
---------------
V
R
Q
F
A
-----
A
E
R
N
V
D
L
S
T
I
D
A
I
A
S
H
G
Q
T
I
W
L
L
S
M
P
E
--
E
G
Q
--------
V
K
S
A
-----
L
T
M
A
------------
E
G
A
I
L
A
S
R
T
G
I
T
----------
S
I
T
--
D
F
-------------------
R
I
S
D
----
Q
A
A
G
R
Q
G
-
A
P
L
I
A
F
F
D
A
L
L
L
H
------
H
P
T
K
L
R
A
C
Q
N
I
G
G
I
A
------
N
V
C
----
F
I
P
P
D
V
D
G
---
R
R
T
D
E
------------
Y
Y
D
F
D
TGPG
N
----
V
F
I
D
A
V
--
V
R
H
F
T
----
N
G
E
Q
E
Y
----------
D
K
D
G
A
M
G
K
R
G
----
K
V
D
Q
E
L
V
D
D
F
L
K
M
P
Y
F
Q
--------
L
D
P
P
K
T
------
T
GREVFR
D
T
L
A
H
D
L
I
R
R
A
E
A
K
G
L
---------
S
P
D
D
I
V
A
T
T
T
R
I
T
A
Q
--
A
I
V
D
H
Y
R
R
YAPSQEI
D
--
E
I
F
M
C
G
G
G
A
Y
N
--------------------
P
N
I
V
E
F
----
I
Q
Q
S
Y
P
--
N
T
K
I
M
M
L
D
E
A
G
V
P
A
----
G
A
K
E
A
I
----------
T
F
A
W
--
Q
G
M
E
A
L
V
G
-----------
R
S
I
P
V
P
T
R
V
E
----------------
T
R
Q
H
--------
Y
V
L
G
K
--
V
S
P
G
L
--
N
Y
R
-----
S
V
--
M
--
K
K
G
---
M
A
F
G
G
D
--
A
Q
Q
L
P
W
V
S
E
M
I
V
K
K
KG
K
V
I
T
NNWAGSHHHH
49
Fugue
64.46
18%
-27
- C2 -
4XLG
4
SLX1_CANGA
A:
[3-300]
--------------------------------------------------------------------------------
E
F
Q
Q
I
P
D
F
Y
G
C
Y
L
L
Q
S
---------------------
I
---
S
K
------
R
Q
S
F
Y
I
G
S
T
P
N
P
V
---------------
R
R
L
R
Q
-----
H
N
G
S
L
S
R
T
K
R
D
G
T
R
P
W
E
M
V
A
I
V
Y
G
F
P
S
---------------------------------------------
R
I
A
A
L
----------
Q
F
Q
H
-
A
W
-------------------
Q
H
G
T
----
R
Y
I
--
S
I
-
H
H
K
L
A
M
-
I
T
S
L
L
K
------
N
-
E
Y
----------
F
------
R
Y
M
----
D
L
T
L
H
F
F
N
---
Q
K
V
E
E
------------
I
W
K
N
D
----
K
-------------
F
N
V
S
----
N
Y
T
V
S
L
----------
S
Q
D
A
L
T
E
-
I
N
----
N
D
T
I
D
D
I
M
D
V
N
E
K
N
M
E
L
--------
V
---
Q
N
------
L
------
Y
S
T
T
L
A
E
K
T
K
T
L
L
L
-
Y
---------
K
E
K
I
D
T
G
I
N
T
C
Q
F
C
N
KI
I
K
H
N
N
I
S
E
-------
N
--
L
F
A
F
C
R
D
T
S
C
-------------------------------------------------------------------------
T
F
V
S
--
H
L
A
C
A
Y
R
Y
---
F
M
S
E
D
---
T
I
I
P
----
Q
S
----------------
P
K
C
--------------------------------------
P
K
C
---
Y
T
L
L
K
W
--
C
D
V
I
Y
Y
S
I
K
L
N
K
------------------
46
Fugue
60.27
22%
49
- C- -
3WPU
2
?
A:
[3-540]
----------------------------------------------------------G
L
Q
D
G
P
E
P
T
I
H
T
Q
Q
A
Y
A
P
E
D
D
F
T
A
K
W
T
R
A
D
A
R
Q
L
Q
R
M
S
D
P
T
A
P
--
S
R
ENS
M
P
A
S
V
T
M
P
T
V
---
P
Q
D
F
P
D
M
S
N
E
Q
V
W
V
W
D
T
W
P
L
T
DEDA
N
Q
Y
S
V
NG
W
E
I
I
F
S
L
V
A
DRNLG
F
D
D
R
H
V
F
A
K
I
G
Y
F
Y
R
P
A
G
V
P
A
A
E
R
P
E
N
GG
W
T
Y
GGLVFKEG
V
T
G
Q
-----
I
F
E
D
Q
S
----------
F
S
H
Q
T
Q
W
S
G
S
A
R
V
S
KNGEIK
L
F
F
T
D
V
A
F
Y
-------------------
R
N
S
D
----
G
T
N
I
K
P
Y
-
D
P
R
I
A
L
S
V
G
K
V
K
A
------
N
K
K
G
----------
V
------
T
L
T
GFN
K
V
T
D
L
L
Q
A
D
GTY
Y
Q
T
G
A
QNEF
F
N
F
R
D
P
F
T
F
E
D
P
A
----
H
PG
E
T
F
M
V
F
E
G
N
S
A
M
Q
R
E
T
A
T
C
N
E
A
D
L
G
YRQGDPYAET
V
D
D
V
N
A
S
G
A
T
Y
Q
I
G
N
V
G
L
A
K
A
K
N
K
Q
L
T
E
W
E
F
L
P
PILSAN
C
V
T
D
Q
T
ER
P
Q
I
Y
F
------
K
D
G
K
S
Y
L
F
T
I
S
H
R
G
-
T
FAAG
L
D
G
P
E
G
V
Y
G
F
V
G
------
D
G
--
I
R
S
D
Y
Q
P
L
-------
N
GG
S
G
L
A
L
G
N
P
T
N
L
NFLGGQPFAPDFNQHPGHFQ
A
Y
S
H
Y
V
M
P
GG
L
V
Q
S
F
I
D
T
I
G
T
H
D
D
F
V
R
G
G
T
L
A
----
P
T
V
K
M
D
I
GVGGDPT
K
T
A
V
D
Y
--
S
Y
G
S
E
G
L
G
---
G
W
A
D
I
PAN
K
H
L
F
----
T
N
----------------
G
K
F
G
--------
V
A
V
S
D
--
E
A
A
Q
K
I
R
K
I
L
-----
G
S
--
K
--
F
D
D
---
Y
L
D
G
K
P
VS
A
T
V
R
A
L
I
E
K
L
L
A
Q
Y----------------
44
Fugue
58.29
16%
-41
* C2 *
4KRT
10
?
A:
[7-353]
--------------------------------------------------------------
H
H
H
H
H
M
Q
S
R
N
N
N
N
-----
L
K
G
I
D
V
S
N
W
K
G
N
I
N
F
E
S
V
K
N
D
--
G
------
V
E
V
V
Y
I
K
A
---
T
E
-
G
N
Y
F
K
D
K
Y
A
K
Q
N
Y
E
G
A
K
E
---------------
Q
G
L
S
V
-----
G
F
Y
H
F
F
R
A
N
--
K
G
A
K
D
Q
A
N
F
F
I
D
Y
L
N
E
--
I
G
A
--------
V
N
Y
D
-----
C
K
L
A
L
D
----------
I
E
T
T
E
G
V
G
V
R
D
L
----------
T
S
M
C
I
E
F
-------------------
L
E
E
V
----
K
R
L
T
G
K
---
E
V
V
V
Y
T
Y
T
S
F
A
N
------
N
N
L
D
----------
S
------
R
L
G
----
N
Y
P
V
W
I
A
H
---
Y
G
V
N
T
------------
P
G
-
A
N
----
N
----
I
W
S
S
W
V
--
G
F
Q
Y
S
----
E
N
G
S
V
-------------
A
G
V
N
G
G
C
D
----
M
N
E
F
T
E
E
I
F
I
D
S
S
--------------------------------
N
F
N
L
D
N
A
T
T
K
N
V
S
-----------
T
K
L
N
I
R
A
K
G
T
T
N
S
K
I
--
I
--
G
S
I
P
A
-------
G
--
E
------------------------------------------
T
F
K
I
--
K
W
V
D
E
D
Y
L
G
W
Y
Y
V
E
YNG
V
V
G
Y
V
N
A
----------
D
Y
V
E
--
K
L
Q
M
A
T
T
Y
NVS
T
F
L
N
V
---
R
E
E
G
----
S
L
----------------
N
S
R
I
--------
V
D
K
I
N
--
S
G
D
I
F
--
R
I
D
-----
W
V
--
D
--
S
D
F
IGW
Y
R
I
T
T
K
--
N
G
K
V
G
F
V
N
A
E
F
V
K
KL---------------
20
PsiBlast_PDB
57.03
25%
-51
- C3 -
3HO8
1
?
A:
[382-438]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
Q
G
A
E
I
S
P
Y
Y
D
S
L
L
V
K
L
S
T
H
A
I
S
--
F
K
Q
--------
A
E
E
K
-----
M
V
R
S
L
R
----------
E
M
R
I
R
G
V
K
T
N
I
P
----------
F
L
-
I
N
V
M
-------------------
K
N
K
K
----
F
T
S
G
D
Y
T
-
T
K
F
I
E
E
T
P
E
L
F
D
I
------
Q
P
S
L
----------
D
------
R
G
T
----
K
T
L
E
Y
I
G
N
---
V
T
I
N
G
------------
F
P
N
V
E
----
K
----
R
P
K
P
D
Y
--
E
L
A
S
I
----
P
T
V
S
S
S
----------
K
I
A
S
F
S
G
T
K
Q
----
L
L
D
E
V
G
P
K
G
V
A
E
W
V
K
K
Q
--------
D
D
V
L
L
T
------
D
------
T
T
F
R
D
A
H
Q
S
L
L
A
T
R
-
V
---------
R
T
K
D
M
I
N
I
A
S
K
T
A
D
V
--
F
K
D
G
F
S
L
E
-------
M
--
W
G
G
A
T
F
D
V
A
Y
N
--------------------
F
L
K
E
N
P
----
W
E
R
L
E
R
--
L
R
K
A
I
P
N
V
L
F
Q
M
L
L
----
R
A
S
N
A
V
----------
G
Y
K
N
--
Y
P
D
N
V
I
H
K
---
F
V
Q
E
S
---
A
K
A
G
----
I
D
----------------
V
F
R
I
--------
F
D
S
L
N
--
W
V
D
Q
M
--
K
V
A
-----
N
E
--
A
--
V
Q
E
---
A
G
K
I
S
E
--
G
T
I
C
Y
T
G
D
I
L
N
P
E
-----------------
11
PsiBlast_PDB
52.65
23%
-52
- C3 -
4AIL
2
DPOL_PYRFU
C:
[516-650]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
G
R
K
Y
I
E
L
V
-------
W
K
E
--------
L
E
E
K
-----
F
G
F
K
V
L
----------
Y
I
D
T
D
G
L
H
A
T
I
P
----------
G
G
E
S
E
E
I
-------------------
K
K
K
A
LEFV
K
Y
I
N
S
K
L
-
P
G
L
L
E
L
E
Y
E
G
F
Y
K
RGFFVT
K
K
R
Y
----------
A
VIDEEG
K
V
I
----
T
R
G
L
E
I
V
R
---
R
D
W
S
E
------------
I
A
K
E
T
----
Q
----
A
R
V
L
E
T
--
I
L
K
H
G
----
D
V
E
E
A
V
RI--------
V
K
E
V
I
Q
K
L
A
N
----
Y
E
I
P
P
E
K
L
A
I
Y
E
Q
I
T
R
P
--------
L
H
E
Y
K
A
------
I
------
G
P
H
V
A
V
A
K
K
L
A
A
K
G
-
V
---------
K
I
K
P
G
M
V
I
G
Y
I
V
L
R
G
--
D
G
P
I
S
N
R
A
-------
I
--
L
A
E
E
Y
D
P
Y
D
A
E
--------------------
Y
Y
I
E
N
Q
----
V
L
P
A
V
L
--
R
I
L
E
G
F
G
Y
R
K
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
52.57
23%
-52
- C3 -
3A2F
-
DPOL_PYRFU
A:
[516-650]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
G
R
K
Y
I
E
L
V
-------
W
K
E
--------
L
E
E
K
-----
F
G
F
K
V
L
----------
Y
I
D
T
D
G
L
Y
A
T
I
P
----------
G
G
E
S
E
E
I
-------------------
K
K
K
A
L
E
F
V
K
Y
I
N
S
K
L
-
P
G
L
L
E
L
E
Y
E
G
F
Y
K
R
G
F
F
VT
K
K
R
Y
----------
A
V
I
D
EEG
K
V
I
----
T
R
G
L
E
I
V
R
---
R
D
W
S
E
------------
I
A
K
E
T
----
Q
----
A
R
V
L
E
T
--
I
L
K
H
G
----
D
V
E
E
A
V
R
I
--------
V
K
E
V
I
Q
K
L
A
N
----
Y
E
I
P
P
E
K
L
A
I
Y
E
Q
I
T
R
P
--------
L
H
E
Y
K
A
------
I
------
G
P
H
V
A
V
A
K
K
L
A
A
K
G
-
V
---------
K
I
K
P
G
M
V
I
G
Y
I
V
L
R
G
--
D
G
P
I
S
N
R
A
-------
I
--
L
A
E
E
Y
D
P
K
K
H
K
--------------------
Y
D
A
E
Y
Y
----
I
E
N
Q
V
L
--
P
A
V
L
R
I
L
E
G
F
G
Y
R
K
----
E
D
L
R
Y
Q
----------
K
T
R
Q
--
V
G
L
T
S
W
L
N
---
I
K
---------------------------------------------------------------------------------------------------------------------
45
Fugue
52.13
9%
-40
- C2 -
1E15
-
?
A:
[3-498]
TR
K
A
V
I
G
Y
Y
F
I
P
T
N
Q
I
N
N
YTETDTSVVPFPVSNIT
P
A
K
A
K
Q
L
T
H
I
N
F
S
F
L
D
I
N
SNLECA
W
D
P
A
T
N
D
A
K
A
R
D
V
V
N
R
L
T
A
L
K
A
H
N
P
S
L
R
I
M
F
S
I
G
G
W
Y
Y
S
N
D
L
--
G
V
---
S
H
A
N
Y
V
N
A
V
K
---
T
P
-
A
S
R
A
K
F
A
Q
S
C
V
R
I
M
K
D
Y
G
---------------
F
D
G
V
D
-----
I
D
W
E
Y
P
Q
A
A
E
V
D
G
F
I
A
A
L
Q
E
I
R
T
L
L
N
Q
--
Q
T
I
--------
T
D
G
R
QAL
P
Y
Q
L
T
I
A
G
A
GG
A
F
F
L
S
R
Y
Y
S
K
L
A
Q
I
V
A
P
L
D
----------
Y
I
N
L
M
T
Y
DLAGPWEK
V
T
N
H
QAALFGD
A
A
G
P
----
T
F
Y
N
A
L
R
-
E
A
N
L
G
W
S
W
E
E
L
T
R
------
A
F
P
S
----------
P
------
F
S
L
----
T
V
D
A
A
V
Q
Q
---
H
L
M
M
E
------------
G
V
P
S
A
----
K
----
I
V
M
G
V
P
--
F
Y
G
R
A
----
F
K
G
V
S
G
----------
G
N
G
G
Q
Y
S
S
H
S
----
T
P
G
E
D
P
Y
P
S
T
D
Y
W
L
V
G
C
--------
E
E
C
V
R
D
------
K
------
D
P
R
I
A
S
Y
R
Q
L
E
Q
M
L
-
Q
---------
G
N
Y
G
Y
Q
R
L
W
N
D
K
T
K
T
--
P
Y
L
Y
H
A
Q
N
-------
G
--
L
F
V
T
Y
D
D
A
E
S
F
--------------------
K
Y
K
A
K
Y
----
I
K
Q
Q
------------
Q
L
G
--------
G
V
M
F
W
----------
H
L
G
Q
DN
R
N
G
D
L
L
A
A
---
L
D
R
Y
F
---
N
A
A
D
----
Y
D
----------------
D
S
Q
L
DMGTGL
R
Y
T
G
V
G
P
--
G
N
L
P
I
--
M
T
A
P
A
YVP
G
T
--
T
--
Y
A
Q
---
G
A
L
V
S
Y
--
Q
G
Y
V
W
Q
T
K
W
G
Y
I
T
SAPGSDSA
W
L
K
V
G
RV--
50
Fugue
51.97
17%
-19
- C1 -
2C3F
2
?
A:
[28-357]
-----------------------------------------------------------
L
R
V
Q
F
K
R
M
K
A
A
E
W
A
R
S
D
V
I
L
L
E
S
E
I
G
F
E
T
D
T
G
F
A
R
A
G
D
G
H
N
R
--------
F
S
D
L
G
Y
I
S
P
---
L
D
-
Y
N
L
L
T
N
K
P
---------
N
---------------
I
D
G
L
A
-----
T
K
V
E
T
A
Q
K
L
Q
Q
K
A
---------
D
K
E
T
V
--
Y
T
K
--------
A
E
S
K
-----
Q
E
L
D
K
K
----------
L
N
L
K
G
G
V
M
T
G
Q
L
----------
K
F
K
P
A
T
G
-------------------
G
A
V
N
----
I
D
L
S
S
T
R
G
A
G
V
V
V
Y
S
D
N
D
T
S
D
------
G
P
L
M
----------
S
------
L
R
T
----
G
K
E
T
F
N
Q
S
---
A
L
F
V
D
------------
Y
K
G
T
T
----
N
----
A
V
--
N
I
--
A
M
R
Q
P
----
T
T
P
N
F
S
----------
S
A
L
N
I
T
S
G
N
E
----
N
G
S
A
M
Q
L
R
G
S
E
K
A
L
G
-----------
T
L
K
I
T
------
H
------
E
N
P
S
I
G
--
A
D
Y
D
K
N
-
A
---------
A
A
L
S
I
D
I
V
K
K
T
N
G
A
G
--
T
A
A
Q
G
I
Y
I
-------
N
--
S
T
S
-----------------------------------------------------------------
G
T
T
G
K
----------
L
L
R
I
--
R
N
L
S
--------
D
D
K
F
---
Y
V
K
S
----
D
G
----------------
G
F
Y
A
--------
K
E
T
S
Q
I
D
G
N
L
K
L
--
K
D
P
-----
T
A
--
N
--
D
H
A
---
A
T
K
A
Y
V
--
D
K
A
I
S
E
L
K
K
L
I
L
K
-----------------
12
PsiBlast_PDB
51.41
23%
-39
- C3 -
2JGU
-
DPOL_PYRFU
A:
[516-650]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
G
R
K
Y
I
E
L
V
-------
W
K
E
--------
L
E
E
K
-----
F
G
F
K
V
L
----------
Y
I
D
T
D
G
L
Y
A
T
I
P
----------
G
G
E
S
E
E
I
-------------------
K
K
K
A
L
E
F
V
K
Y
I
N
S
K
L
-
P
G
L
L
E
L
E
Y
E
G
F
Y
K
R
G
F
F
VT
K
K
R
Y
----------
A
V
I
D
EEG
K
V
I
----
T
R
G
L
E
---------
S
E
------------
I
A
K
E
T
----
Q
----
A
R
V
L
E
T
--
I
L
K
H
G
----
D
V
E
E
A
V
R
I
--------
V
K
E
V
I
Q
K
L
A
N
----
Y
E
I
P
P
E
K
L
A
P
H
V
A
V
A
K
K
--------
L
A
A
K
G
V
------
K
------
I
K
P
G
M
V
I
G
Y
I
V
D
A
E
-
Y
---------
Y
I
E
N
Q
V
L
P
A
V
L
R
I
L
E
--
G
F
G
Y
R
K
E
D
-------
L
--
R
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
49.71
25%
-66
- C3 -
3HBL
-
?
A:
[382-438]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
Q
G
A
E
I
S
P
Y
Y
D
S
L
L
V
K
L
S
T
H
A
I
S
--
F
K
Q
--------
A
E
E
K
-----
M
V
R
S
L
R
----------
E
M
R
I
R
G
V
K
T
N
I
P
----------
F
L
-
I
N
V
M
-------------------
K
N
K
K
----
F
T
S
G
D
Y
T
-
T
K
F
I
E
E
T
P
E
L
F
D
I
------
Q
P
S
L
----------
D
------
R
G
T
----
K
T
L
E
Y
I
G
N
---
V
T
I
N
G
------------
F
P
N
V
E
----
K
----
R
P
K
P
D
Y
--
E
L
A
S
I
----
P
T
V
S
S
S
----------
K
I
A
S
F
S
G
T
K
Q
----
L
L
D
E
V
G
P
K
G
V
A
E
W
V
K
K
Q
--------
D
D
V
L
L
T
------
D
------
T
T
F
R
D
A
H
Q
S
L
L
A
T
R
-
V
---------
R
T
K
D
M
I
N
I
A
S
K
T
A
D
V
--
F
K
D
G
F
S
L
E
-------
M
--
W
G
G
A
T
F
D
V
A
Y
N
--------------------
F
L
K
E
N
P
----
W
E
R
L
E
R
--
L
R
K
A
I
P
N
V
L
F
Q
M
L
L
----
R
A
S
N
A
V
----------
G
Y
K
N
--
Y
P
D
N
V
I
H
K
---
F
V
Q
E
S
---
A
K
A
G
----
I
D
----------------
V
F
R
I
--------
F
D
S
L
N
--
W
V
D
Q
M
--
K
V
A
-----
N
E
--
A
--
V
Q
E
---
A
G
K
I
S
E
--
G
T
I
C
Y
T
G
D
I
L
N
P
E
-----------------
28
HHSearch
49.41
13%
7
- C4 -
3M1U
6
?
A:
[113-190]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
--
Q
A
W
K
G
I
V
V
---
S
N
S
A
L
---
R
E
V
P
----
T
L
R
P
M
F
TAPTRAGQGYPF
D
M
F
Q
--------
R
T
A
V
W
--
M
G
T
P
V
--
F
V
G
-----
H
A
--
T
AD
R
A
W
---
L
Y
V
E
T
---
A
F
A
A
G
W
M
P
A
A
D
V
A
-----------------
17
PsiBlast_PDB
49.29
25%
-60
- C3 -
3BG5
-
?
A:
[405-461]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
Q
G
A
E
I
S
P
Y
Y
D
S
L
L
V
K
L
S
T
H
A
I
S
--
F
K
Q
--------
A
E
E
K
-----
M
V
R
S
L
R
----------
E
M
R
I
R
G
V
K
T
N
I
P
----------
F
L
-
I
N
V
M
-------------------
K
N
K
K
----
F
T
S
G
D
Y
T
-
T
K
F
I
E
E
T
P
E
L
F
D
I
------
Q
P
S
L
----------
D
------
R
G
T
----
K
T
L
E
Y
I
G
N
---
V
T
I
N
G
------------
F
P
N
V
E
----
K
----
R
P
K
P
D
Y
--
E
L
A
S
I
----
P
T
V
S
S
S
----------
K
I
A
S
F
S
G
T
K
Q
----
L
L
D
E
V
G
P
K
G
V
A
E
W
V
K
K
Q
--------
D
D
V
L
L
T
------
D
------
T
T
F
R
D
A
H
Q
S
L
L
A
T
R
-
V
---------
R
T
K
D
M
I
N
I
A
S
K
T
A
D
V
--
F
K
D
G
F
S
L
E
-------
M
--
W
G
G
A
T
F
D
V
A
Y
N
--------------------
F
L
K
E
N
P
----
W
E
R
L
E
R
--
L
R
K
A
I
P
N
V
L
F
Q
M
L
L
----
R
A
S
N
A
V
----------
G
Y
K
N
--
Y
P
D
N
V
I
H
K
---
F
V
Q
E
S
---
A
K
A
G
----
I
D
----------------
V
F
R
I
--------
F
D
S
L
N
--
W
V
D
Q
M
--
K
V
A
-----
N
E
--
A
--
V
Q
E
---
A
G
K
I
S
E
--
G
T
I
C
Y
T
G
D
I
L
N
P
E
-----------------
4
PsiBlast_PDB
48.30
27%
-57
- C3 -
4HNU
-
?
A:
[405-461]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
Q
G
A
E
I
S
P
Y
Y
D
S
L
L
V
K
L
S
T
H
A
I
S
--
F
K
Q
--------
A
E
E
E
-----
M
V
R
S
L
R
----------
E
M
R
I
R
G
V
K
T
N
I
P
----------
F
L
-
I
N
V
M
-------------------
K
N
K
K
----
F
T
S
G
D
Y
T
-
T
K
F
I
E
E
T
P
E
L
F
D
I
------
Q
P
S
L
----------
D
------
R
G
T
----
K
T
L
E
Y
I
G
N
---
V
T
I
N
G
------------
F
P
N
V
E
----
K
----
R
P
K
P
D
Y
--
E
L
A
S
I
----
P
T
V
S
S
S
----------
K
I
A
S
F
S
G
T
K
Q
----
L
L
D
E
V
G
P
K
G
V
A
E
W
V
K
K
Q
--------
D
D
V
L
L
T
------
D
------
T
T
F
R
D
A
H
Q
S
L
L
A
T
R
-
V
---------
R
T
K
D
M
I
N
I
A
S
K
T
A
D
V
--
F
K
D
G
F
S
L
E
-------
M
--
W
G
G
A
T
F
D
V
A
Y
N
--------------------
F
L
K
E
N
P
----
W
E
R
L
E
R
--
L
R
K
A
I
P
N
V
L
F
Q
M
L
L
----
R
A
S
N
A
V
----------
G
Y
K
N
--
Y
P
D
N
V
I
H
K
---
F
V
Q
E
S
---
A
K
A
G
----
I
D
----------------
V
F
R
I
--------
F
D
S
L
N
--
W
V
D
Q
M
--
K
V
A
-----
N
E
--
A
--
V
Q
E
---
A
G
K
I
S
E
--
G
T
I
C
Y
T
G
D
I
L
N
P
E
-----------------
18
PsiBlast_PDB
47.60
25%
-61
- C3 -
3HB9
-
?
A:
[382-438]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
Q
G
A
E
I
S
P
Y
Y
D
S
L
L
V
K
L
S
T
H
A
I
S
--
F
K
Q
--------
A
E
E
K
-----
M
V
R
S
L
R
----------
E
M
R
I
R
G
V
K
T
N
I
P
----------
F
L
-
I
N
V
M
-------------------
K
N
K
K
----
F
T
S
G
D
Y
T
-
T
K
F
I
E
E
T
P
E
L
F
D
I
------
Q
P
S
L
----------
D
------
R
G
T
----
K
T
L
E
Y
I
G
N
---
V
T
I
N
G
------------
F
P
N
V
E
----
K
----
R
P
K
P
D
Y
--
E
L
A
S
I
----
P
T
V
S
S
S
----------
K
I
A
S
F
S
G
T
K
Q
----
L
L
D
E
V
G
P
K
G
V
A
E
W
V
K
K
Q
--------
D
D
V
L
L
T
------
D
------
T
T
F
R
D
A
H
Q
S
L
L
A
T
R
-
V
---------
R
T
K
D
M
I
N
I
A
S
K
T
A
D
V
--
F
K
D
G
F
S
L
E
-------
M
--
W
G
G
T
T
F
D
V
A
Y
N
--------------------
F
L
K
E
N
P
----
W
E
R
L
E
R
--
L
R
K
A
I
P
N
V
L
F
Q
M
L
L
----
R
A
S
N
A
V
----------
G
Y
K
N
--
Y
P
D
N
V
I
H
K
---
F
V
Q
E
S
---
A
K
A
G
----
I
D
----------------
V
F
R
I
--------
F
D
S
L
N
--
W
V
D
Q
M
--
K
V
A
-----
N
E
--
A
--
V
Q
E
---
A
G
K
I
S
E
--
G
T
I
C
Y
T
G
D
I
L
N
P
E
-----------------
24
HHSearch
47.53
22%
34
- C4 -
3NPF
4
?
A:
[11-67]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
A
Y
G
V
V
H
I
---
S
V
C
N
L
---
R
E
E
G
----
K
F
----------------
T
S
G
M
--------
S
T
Q
A
L
--
L
G
M
P
V
--
K
V
L
-----
Q
---
Y
--
N
G
W
---
Y
E
I
Q
T
P
--
D
D
Y
T
G
W
V
H
R
M
V
I
T
-----------------
25
HHSearch
46.40
21%
27
- C4 -
2KT8
-
?
A:
[10-61]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
---
S
S
L
N
V
---
R
E
G
A
----
S
T
----------------
S
S
K
V
--------
I
G
S
L
S
--
G
N
T
K
V
--
T
I
V
-----
G
E
--
E
--
G
A
F
---
Y
K
I
E
Y
---
K
G
S
H
G
Y
V
A
K
E
Y
I
K
-----------------
34
HHSearch
45.10
14%
47
- C4 -
1K9A
-
CSK_RAT
A:
[27-65]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
P
F
C
--
K
G
D
V
L
--
T
I
V
-----
A
V
TK
D
--
P
N
W
---
Y
K
A
K
N
K
--
V
G
R
E
G
I
I
P
A
N
Y
V
Q
-----------------
33
HHSearch
43.72
11%
38
* C4 *
1QCF
-
A:
[24-61]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
S
F
Q
--
K
G
D
Q
M
--
V
V
L
-----
E
E
--
S
--
G
E
W
---
W
K
A
R
S
L
A-
T
R
K
E
G
Y
I
P
S
N
Y
V
A
-----------------
37
HHSearch
42.12
18%
60
- C4 -
2K2M
-
ES8L1_HUMAN
A:
[499-532]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
--
Q
R
D
V
L
--
E
V
L
-----
D
D
--
S
--
R
K
W
---
W
K
V
R
D
P
--
A
G
Q
E
G
Y
V
P
Y
N
I
L
------------------