@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_1323: (2015-12-22 )
MTDNNQNNENHENSSENSKDHHEARAGAFERFTNRKKRFRENAQKNAESSNHETLSHHKKEHRPNKKPNNHHKPKHASQKTRNYAKEELDNNKVEGVTEILHVNERGTLGFHKELKKGVEANNKIQVEHLNPHYKMNLNSKASVKITPLGGLGEIGGNMMVIETPKSAIVIDAGMSFPKEGLFGVDILIPDFSYLHQIKDKIAGIIITHAHEDHIGATPYLFKELQFPLYGTPLSLGLIGSKFDEHGLKKYRSYFKIVEKRCPISVGEFIIEWIHITHSIIDSSALAIQTKAGTIIHTGDFKIDHTPVDNLPTDLYRLAHYGEKGVMLLLSDSTNSHKSGTTPSESTIAPAFDTLFKEAQGRVIMSTFSSNIHRVHQAIQYGIKYNRKIAVIGRSMEKNLDIARELGYIHLPYQSFIEANEVAKYPDNEVLIVTTGSQGETMSALYRMATDEHRHISIKPNDLVIISAKAIPGNEASVSAVLNFLIKKEAKVAYQEFDNIHVSGHAAQEEQKLMLRLIKPKFFLPVHGEYNHVARHKQTAIACGVPEKNIYLMEDGDQVEVGPAFIKKVGTIKSGKSYVDNQSNLSIDTSIVQQREEVASAGVFAATIFVNKNKQALLESSQFSSLGLVGFKDEKHLIKEIQGGLEVLLKSSNAEILNNPKKLEDHTRNFIRKALFKKFRKYPAIICHAHSF
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......---------180.-----------.-------.-.--------...190...------------....200---.......210.......220-----..--.-----....230--......--------..240......---------.250-----------.----------........260....-.-.-.270.......280.......290.--........300.-......310-------......---.320.......330.......340-------.--.......350.....---.---.-360-.......370.......380....--------.-------..390.......400---.-...-...410-----------.---.---.---....------420----..--..--.....430.....--.--.440.......450.......460.....-..470...-..-..-480.---------.--------------...-..----490..-..--...-500........510.......--520.......530.......-540.....---...550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MTDNNQNNENHENSSENS
K
D
H
H
E
A
R
A
G
A
F
E
R
F
T
N
R
K
K
R
F
R
E
N
A
QKNAESSN
H
E
T
L
S
H
H
K
K
EHRPNKKPNNHHKPKH
A
S
Q
K
T
R
N
Y
A
K
E
ELDNN
K
V
E
G
V
T
E
I
LHVNERGTLG
F
H
K
E
L
K
K
GVEAN
N
K
I
Q
V
E
HLNP
H
Y
K
M
NLNSK
A
S
V
K
I
T
PLGG
L
G
EIGG
N
M
M
V
I
ETPK
S
A
I
V
I
DAGMSFPK---------EGL
F
-----------
G
-------
V
-
D
--------
I
LIP
D
F
S
Y
L
------------
H
Q
I
K
D
KI---
A
G
I
I
I
T
HAHEDHIGA
T
P
Y
L
F
-----
K
E
--L-----QFPLYG---TPL
S
L
G
--------
L
IGS
K
F
D
E
H
G
L
---------
K
K
-------------
Y
----------
R
S
Y
F
K
I
V
E
K
RCPI
S
V
-
G
-
E
-
F
I
I
E
W
I
H
I
T
H
S
I
IDSS
A
L
A
I
Q
T--K--A
G
T
I
I
HTG
D
F
K
I
-DHTPVDNL
P
-------
T
D
L
Y
R
L
---
A
HYGEK
G
V
M
L
L
LSDSTNSHKSGT--------T--PSESTI
A
P
A
F
D
T
L
F
K
---E---A-QG
R
-
V
I
M
S
T
F
S
S
N
I
H
R
V
H
Q
A
I
Q
Y
G
IKYN--------
R
-------
K
I
A
V
IGR
S
M
E
K
N
L
D
I
---
A
-
R
EL-
G
Y
I
HL
P
-----------
Y
---
Q
---
S
---
F
I
E
A
------
N
------
E
V--AK--YPDN
E
V
L
I
V
T
TGS--Q--G
E
T
M
S
A
L
Y
R
MATDEH
R
H
I
S
IKPN
D
L
V
I
I
S
-
A
KAIPGN
E
-
A
S
-
V
S
-
A
V
L
N
---------
F
--------------
L
I
K
-
K
E
----
A
K
V
A
Y
-
Q
E--FD
N
-
I
-
H
VSGHA
A
Q
E
E
Q
K
L
M
L
R
LIK--
P
K
F
F
L
P
VHGE
Y
N
H
V
A
R
H
KQ
T
-
A
-
I
ACGVP---EK
N
I
Y
L
MEDGDQVEV
G
P
A
F
I
K
K
VGTIKSGKSYVDNQSNLS
I
D
T
S
I
V
Q
Q
R
E
E
V
ASAG
V
F
A
A
T
I
F
VNK
N
K
Q
A
L
L
ESSQFSSLGLVGFK
D
E
K
H
L
I
K
E
I
Q
G
G
L
E
V
L
L
KSSNAEILN
N
P
K
K
L
E
D
H
T
R
N
F
I
R
K
A
L
F
K
K
F
RKY
P
A
I
I
C
HAHSF
22
PsiBlast_CBE
93.77
39%
-104
- C1 -
3ZQ4
4
RNJ1_BACSU
D:
[14-549]
----------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
L
G
E
I
G
K
N
T
Y
A
V
Q
F
Q
D
E
I
V
L
I
D
A
G
I
K
F
P
E
---------
D
E
L
L
-----------
G
-------
I
-
D
--------
Y
V
I
P
D
Y
T
Y
L
------------
V
K
N
E
D
K
I
---
K
G
L
F
I
T
H
G
H
E
D
H
I
G
G
I
P
Y
L
L
-----
R
Q
--
V
-----
N
I
P
V
Y
G
---
G
K
L
A
I
G
--------
L
L
R
N
K
L
E
E
H
G
L
---------
L
R
------------------------
Q
T
K
L
N
I
I
G
E
D
D
I
V
K
F
-
R
-
K
-
T
A
V
S
F
F
R
T
T
H
S
I
P
D
S
Y
G
I
V
V
K
T
--
P
--
P
G
N
I
V
H
T
G
D
F
K
F
-
D
F
T
P
V
G
E
-
P
-------
A
N
L
T
K
M
---
A
E
I
G
K
E
G
V
L
C
L
L
S
D
S
T
N
S
E
N
P
E
F
--------
T
--
M
S
E
R
R
V
G
E
S
I
H
D
I
F
R
---
K
---
V
-
D
G
R
-
I
I
F
A
T
F
A
S
N
I
H
R
L
Q
Q
V
I
E
A
A
V
Q
N
G
--------
R
-------
K
V
A
V
F
G
R
S
M
E
S
A
I
E
I
---
G
-
Q
T
L
-
G
Y
I
N
C
P
-----------
K
---
N
---
T
---
F
I
E
H
------
N
------
E
I
--
N
R
--
M
P
A
N
K
V
T
I
L
C
T
G
S
--
Q
--
G
E
P
M
A
A
L
S
R
I
A
N
G
T
H
R
Q
I
S
I
N
P
G
D
T
V
V
F
S
-
S
S
P
I
P
G
N
T
-
I
S
-
V
S
-
R
T
I
N
---------
Q
--------------
L
Y
R
-
A
G
----
A
E
V
I
H
-
G
P
--
L
N
D
-
I
-
H
T
S
G
H
G
G
Q
E
E
Q
K
L
M
L
R
L
I
K
--
P
K
F
F
M
P
I
H
G
E
Y
R
M
Q
K
M
H
V
K
L
-
A
-
T
D
C
G
I
P
---
E
E
N
C
F
I
M
D
N
G
E
V
L
A
L
K
G
D
E
A
S
V
A
G
K
I
P
S
G
S
V
Y
I
D
G
S
G
I
G
D
I
G
N
I
V
L
R
D
R
R
I
L
S
E
E
G
L
V
I
V
V
V
S
I
D
M
D
D
F
K
I
S
A
G
P
D
L
I
S
R
G
F
V
------
D
L
I
N
D
A
Q
E
L
I
S
N
H
L
Q
K
V
M
------
W
S
E
I
K
N
E
I
T
D
T
L
A
P
F
L
Y
E
K
T
K
R
R
P
M
I
L
P
I
I
M
E
V
1
PsiBlast_PDB
92.78
39%
-100
- C1 -
3ZQ4
4
RNJ1_BACSU
A:
[14-549]
----------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
L
G
E
I
G
K
N
T
Y
A
V
Q
F
Q
D
E
I
V
L
I
D
A
G
I
K
F
P
E
---------
D
E
L
L
-----------
G
-------
I
-
D
--------
Y
V
I
P
D
Y
T
Y
L
------------
V
K
N
E
D
K
I
---
K
G
L
F
I
T
H
G
H
E
D
H
I
G
G
I
P
Y
L
L
-----
R
Q
--
V
-----
N
I
P
V
Y
G
---
G
K
L
A
I
G
--------
L
L
R
N
K
L
E
E
H
G
L
---------
L
R
------------------------
Q
T
K
L
N
I
I
G
E
D
D
I
V
K
F
-
R
-
K
-
T
A
V
S
F
F
R
T
T
H
S
I
P
D
S
Y
G
I
V
V
K
T
--
P
--
P
G
N
I
V
H
T
G
D
F
K
F
-
D
F
T
P
V
G
E
-
P
-------
A
N
L
T
K
M
---
A
E
I
G
K
E
G
V
L
C
L
L
S
D
S
T
N
S
E
N
P
E
F
--------
T
--
M
S
E
R
R
V
G
E
S
I
H
D
I
F
R
---
K
---
V
-
D
G
R
-
I
I
F
A
T
F
A
S
N
I
H
R
L
Q
Q
V
I
E
A
A
V
Q
N
G
--------
R
-------
K
V
A
V
F
G
R
S
M
E
S
A
I
E
I
---
G
-
Q
T
L
-
G
Y
I
N
C
P
-----------
K
---
N
---
T
---
F
I
E
H
------
N
------
E
I
--
N
R
--
M
P
A
N
K
V
T
I
L
C
T
G
S
--
Q
--
G
E
P
M
A
A
L
S
R
I
A
N
G
T
H
R
Q
I
S
I
N
P
G
D
T
V
V
F
S
-
S
S
P
I
P
G
N
T
-
I
S
-
V
S
-
R
T
I
N
---------
Q
--------------
L
Y
R
-
A
G
----
A
E
V
I
H
-
G
P
--
L
N
D
-
I
-
H
T
S
G
H
G
G
Q
E
E
Q
K
L
M
L
R
L
I
K
--
P
K
F
F
M
P
I
H
G
E
Y
R
M
Q
K
M
H
V
K
L
-
A
-
T
D
C
G
I
P
---
E
E
N
C
F
I
M
D
N
G
E
V
L
A
L
K
G
D
E
A
S
V
A
G
K
I
P
S
G
S
V
Y
I
D
G
S
G
I
G
D
I
G
N
I
V
L
R
D
R
R
I
L
S
E
E
G
L
V
I
V
V
V
S
I
D
M
D
D
F
K
I
S
A
G
P
D
L
I
S
R
G
F
V
Y
M
R
E
S
G
D
L
I
N
D
A
Q
E
L
I
S
N
H
L
Q
K
V
M
E
R
K
T
T
Q
W
S
E
I
K
N
E
I
T
D
T
L
A
P
F
L
Y
E
K
T
K
R
R
P
M
I
L
P
I
I
M
E
V
23
PsiBlast_CBE
92.19
39%
-100
- C1 -
3ZQ4
4
RNJ1_BACSU
C:
[14-549]
----------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
L
G
E
I
G
K
N
T
Y
A
V
Q
F
Q
D
E
I
V
L
I
D
A
G
I
K
F
P
E
---------
D
E
L
L
-----------
G
-------
I
-
D
--------
Y
V
I
P
D
Y
T
Y
L
------------
V
K
N
E
D
K
I
---
K
G
L
F
I
T
H
G
H
E
D
H
I
G
G
I
P
Y
L
L
-----
R
Q
--
V
-----
N
I
P
V
Y
G
---
G
K
L
A
I
G
--------
L
L
R
N
K
L
E
E
H
G
L
---------
L
R
------------------------
Q
T
K
L
N
I
I
G
E
D
D
I
V
K
F
-
R
-
K
-
T
A
V
S
F
F
R
T
T
H
S
I
P
D
S
Y
G
I
V
V
K
T
--
P
--
P
G
N
I
V
H
T
G
D
F
K
F
-
D
F
T
P
V
G
E
-
P
-------
A
N
L
T
K
M
---
A
E
I
G
K
E
G
V
L
C
L
L
S
D
S
T
N
S
E
N
P
E
F
--------
T
--
M
S
E
R
R
V
G
E
S
I
H
D
I
F
R
---
K
---
V
-
D
G
R
-
I
I
F
A
T
F
A
S
N
I
H
R
L
Q
Q
V
I
E
A
A
V
Q
N
G
--------
R
-------
K
V
A
V
F
G
R
S
M
E
S
A
I
E
I
---
G
-
Q
T
L
-
G
Y
I
N
C
P
-----------
K
---
N
---
T
---
F
I
E
H
------
N
------
E
I
--
N
R
--
M
P
A
N
K
V
T
I
L
C
T
G
S
--
Q
--
G
E
P
M
A
A
L
S
R
I
A
N
G
T
H
R
Q
I
S
I
N
P
G
D
T
V
V
F
S
-
S
S
P
I
P
G
N
T
-
I
S
-
V
S
-
R
T
I
N
---------
Q
--------------
L
Y
R
-
A
G
----
A
E
V
I
H
-
G
P
--
L
N
D
-
I
-
H
T
S
G
H
G
G
Q
E
E
Q
K
L
M
L
R
L
I
K
--
P
K
F
F
M
P
I
H
G
E
Y
R
M
Q
K
M
H
V
K
L
-
A
-
T
D
C
G
I
P
---
E
E
N
C
F
I
M
D
N
G
E
V
L
A
L
K
G
D
E
A
S
V
A
G
K
I
P
S
G
S
V
Y
I
D
G
S
G
I
G
D
I
G
N
I
V
L
R
D
R
R
I
L
S
E
E
G
L
V
I
V
V
V
S
I
D
M
D
D
F
K
I
S
A
G
P
D
L
I
S
R
G
F
V
--------
I
N
D
A
Q
E
L
I
S
N
H
L
Q
K
V
M
E
R
K
T
T
Q
W
S
E
I
K
N
E
I
T
D
T
L
A
P
F
L
Y
E
K
T
K
R
R
P
M
I
L
P
I
I
M
E
V
21
PsiBlast_CBE
91.26
39%
-102
- C1 -
3ZQ4
4
RNJ1_BACSU
E:
[14-549]
----------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
L
G
E
I
G
K
N
T
Y
A
V
Q
F
Q
D
E
I
V
L
I
D
A
G
I
K
F
P
E
---------
D
E
L
L
-----------
G
-------
I
-
D
--------
Y
V
I
P
D
Y
T
Y
L
------------
V
K
N
E
D
K
I
---
K
G
L
F
I
T
H
G
H
E
D
H
I
G
G
I
P
Y
L
L
-----
R
Q
--
V
-----
N
I
P
V
Y
G
---
G
K
L
A
I
G
--------
L
L
R
N
K
L
E
E
H
G
L
---------
L
R
------------------------
Q
T
K
L
N
I
I
G
E
D
D
I
V
K
F
-
R
-
K
-
T
A
V
S
F
F
R
T
T
H
S
I
P
D
S
Y
G
I
V
V
K
T
--
P
--
P
G
N
I
V
H
T
G
D
F
K
F
-
D
F
T
P
V
G
E
-
P
-------
A
N
L
T
K
M
---
A
E
I
G
K
E
G
V
L
C
L
L
S
D
S
T
N
S
E
N
P
E
F
--------
T
--
M
S
E
R
R
V
G
E
S
I
H
D
I
F
R
---
K
---
V
-
D
G
R
-
I
I
F
A
T
F
A
S
N
I
H
R
L
Q
Q
V
I
E
A
A
V
Q
N
G
--------
R
-------
K
V
A
V
F
G
R
S
M
E
S
A
I
E
I
---
G
-
Q
T
L
-
G
Y
I
N
C
P
-----------
K
---
N
---
T
---
F
I
E
H
------
N
------
E
I
--
N
R
--
M
P
A
N
K
V
T
I
L
C
T
G
S
--
Q
--
G
E
P
M
A
A
L
S
R
I
A
N
G
T
H
R
Q
I
S
I
N
P
G
D
T
V
V
F
S
-
S
S
P
I
P
G
N
T
-
I
S
-
V
S
-
R
T
I
N
---------
Q
--------------
L
Y
R
-
A
G
----
A
E
V
I
H
-
G
P
--
L
N
D
-
I
-
H
T
S
G
H
G
G
Q
E
E
Q
K
L
M
L
R
L
I
K
--
P
K
F
F
M
P
I
H
G
E
Y
R
M
Q
K
M
H
V
K
L
-
A
-
T
D
C
G
I
P
---
E
E
N
C
F
I
M
D
N
G
E
V
L
A
L
K
G
D
E
A
S
V
A
G
K
I
P
S
G
S
V
Y
I
D
G
S
G
I
G
D
I
G
N
I
V
L
R
D
R
R
I
L
S
E
E
G
L
V
I
V
V
V
S
I
D
M
D
D
F
K
I
S
A
G
P
D
L
I
S
R
G
F
V
------
D
L
I
N
D
A
Q
E
L
I
S
N
H
L
Q
K
V
M
E
R
K
T
T
Q
W
S
E
I
K
N
E
I
T
D
T
L
A
P
F
L
Y
E
K
T
K
R
R
P
M
I
L
P
I
I
M
E
V
30
HHSearch
89.40
39%
-92
- C1 -
3BK2
7
RNJ_THET2
A:
[14-561]
--------------------------------------------------------------------------------------------------------------------------------------------
Q
D
H
V
E
I
I
P
L
G
G
M
G
E
I
G
K
N
I
T
V
F
R
F
R
D
E
I
F
V
L
D
G
G
L
A
F
P
E
---------
E
G
M
P
-----------
G
-------
V
-
D
--------
L
L
I
P
R
V
D
Y
L
------------
I
E
H
R
H
K
I
---
K
A
W
V
L
T
H
G
H
E
D
H
I
G
G
L
P
F
L
L
-----
P
M
--
I
FGKES
P
V
P
I
Y
G
---
A
R
L
T
L
G
--------
L
L
R
G
K
L
E
E
F
G
L
---------
R
P
G------------
A
----------
F
N
L
-
K
E
I
S
P
D
D
R
I
Q
V
-
G
R
Y
-
F
T
L
D
L
F
R
M
T
H
S
I
P
D
N
S
G
V
V
I
R
T
--
P
--
I
G
T
I
V
H
T
G
D
F
K
L
-
D
P
T
P
I
D
G
K
V
-------
S
H
L
A
K
V
---
A
Q
A
G
A
E
G
V
L
L
L
I
A
D
A
T
N
A
E
R
P
G
Y
--------
T
--
P
S
E
M
E
I
A
K
E
L
D
R
V
I
G
---
R
---
A
-
P
G
R
-
V
F
V
T
T
F
A
S
H
I
H
R
I
Q
S
V
I
W
A
A
E
K
Y
G
--------
R
-------
K
V
A
M
E
G
R
S
M
L
K
F
S
R
I
---
A
-
L
E
L
-
G
Y
L
K
V
K
-----------
D
-------
R
---
L
Y
T
L
------
E
------
E
V
--
K
D
--
L
P
D
H
Q
V
L
I
L
A
T
G
S
--
Q
--
G
Q
P
M
S
V
L
H
R
L
A
F
E
G
H
A
K
M
A
I
K
P
G
D
T
V
I
L
S
-
S
S
P
I
P
G
N
E
-
E
A
-
V
N
-
R
V
I
N
---------
R
--------------
L
Y
A
-
L
G
----
A
Y
V
L
Y
-
P
P
--
T
Y
K
-
V
-
H
A
S
G
H
A
S
Q
E
E
L
K
L
I
L
N
L
T
T
--
P
R
F
F
L
P
W
H
G
E
V
R
H
Q
M
N
F
K
W
L
-
A
-
E
S
M
S
R
P
---
P
E
K
T
L
I
G
E
N
G
A
V
Y
R
L
T
R
E
T
F
E
K
V
G
E
V
P
H
G
V
L
Y
V
D
G
L
G
V
G
D
I
T
E
E
I
L
A
D
R
R
H
M
A
E
E
G
L
V
V
I
T
A
L
A
G
E
D
P
-----
V
V
E
V
V
S
R
G
F
V
K
A
G
--
E
R
L
L
G
E
V
R
R
M
A
L
E
A
L
K
N
G
V
R
-
E
K
K
P
L
E
R
I
R
D
D
I
Y
Y
P
V
K
K
F
L
K
K
A
T
G
R
D
P
M
I
L
P
V
V
I
E
G
24
PsiBlast_CBE
83.83
35%
-100
- C1 -
5A0V
4
?
B:
[16-452]
--------------------------------------------------------------------------------------------------------------------------------------------
K
G
G
L
R
V
T
P
L
G
G
L
G
E
I
G
R
N
M
T
V
F
E
Y
G
G
R
L
L
I
V
D
C
G
V
L
F
P
E
---------
E
E
Q
P
-----------
G
-------
I
-
D
--------
L
I
L
P
D
F
T
S
I
------------
R
D
R
L
D
D
I
---
E
G
I
V
L
T
H
G
H
E
D
H
I
G
G
V
P
F
L
L
-----
R
E
K-
P
-----
D
I
P
L
I
G
---
S
K
L
T
L
A
--------
L
I
E
A
K
L
Q
E
H
------------
R
-------------
I
----------
R
P
Y
T
L
E
V
A
E
G
H
R
E
R
V
-
G
-
P
-
F
D
C
E
F
V
A
V
N
H
S
I
P
D
A
L
A
V
A
I
R
T
--
P
--
A
G
M
V
V
H
T
G
D
F
K
M
-
D
Q
L
P
L
D
G
R
L
-------
T
D
L
H
A
F
---
A
R
L
S
E
E
G
I
D
L
L
L
A
D
S
T
N
A
E
V
P
G
F
--------
V
--
P
P
E
R
D
I
S
N
V
L
R
Q
V
F
A
---
N
---
A
-
R
K
R
-
I
I
V
A
S
F
A
S
H
V
H
R
I
Q
Q
I
L
D
A
A
H
E
Y
G
--------
R
-------
R
V
A
F
V
G
R
S
M
V
R
N
M
G
I
---
A
-
R
D
L
-
G
Y
L
K
V
P
-----------
P
---
G
---
L
---
V
V
D
V
------
K
------
T
L
--
D
D
--
L
P
D
S
E
V
V
L
V
C
T
G
S
--
Q
--
G
E
P
M
A
A
L
S
R
M
A
N
R
D
H
Q
-
I
R
I
V
N
G
D
T
V
I
L
A
-
S
S
L
I
P
G
N
E
-
N
A
-
V
Y
-
R
V
I
N
---------
G
--------------
L
T
R
-
W
G
----
A
N
V
V
H
-
K
G
--
N
A
K
-
V
-
H
V
S
G
H
A
S
A
G
E
L
L
Y
F
Y
N
I
C
R
--
P
K
N
L
M
P
V
H
G
E
W
R
H
L
R
A
N
A
E
L
-
G
-
A
L
T
G
V
P
---
H
D
R
I
V
I
A
E
D
G
V
V
V
D
L
V
E
G
K
A
K
I
T
G
K
V
Q
A
G
Y
V
Y
V
D
----------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
83.65
35%
-99
- C1 -
5A0T
4
?
B:
[16-452]
--------------------------------------------------------------------------------------------------------------------------------------------
K
G
G
L
R
V
T
P
L
G
G
L
G
E
I
G
R
N
M
T
V
F
E
Y
G
G
R
L
L
I
V
D
C
G
V
L
F
P
E
---------
E
E
Q
P
-----------
G
-------
I
-
D
--------
L
I
L
P
D
F
T
S
I
------------
R
D
R
L
D
D
I
---
E
G
I
V
L
T
H
G
H
E
D
H
I
G
G
V
P
F
L
L
-----
R
E
K-
P
-----
D
I
P
L
I
G
---
S
K
L
T
L
A
--------
L
I
E
A
K
L
Q
E
H
------------
R
-------------
I
----------
R
P
Y
T
L
E
V
A
E
G
H
R
E
R
V
-
G
-
P
-
F
D
C
E
F
V
A
V
N
H
S
I
P
D
A
L
A
V
A
I
R
T
--
P
--
A
G
M
V
V
H
T
G
D
F
K
M
-
D
Q
L
P
L
D
G
R
L
-------
T
D
L
H
A
F
---
A
R
L
S
E
E
G
I
D
L
L
L
A
D
S
T
N
A
E
V
P
G
F
--------
V
--
P
P
E
R
D
I
S
N
V
L
R
Q
V
F
A
---
N
---
A
-
R
K
R
-
I
I
V
A
S
F
A
S
H
V
H
R
I
Q
Q
I
L
D
A
A
H
E
Y
G
--------
R
-------
R
V
A
F
V
G
R
S
M
V
R
N
M
G
I
---
A
-
R
D
L
-
G
Y
L
K
V
P
-----------
P
---
G
---
L
---
V
V
D
V
------
K
------
T
L
--
D
D
--
L
P
D
S
E
V
V
L
V
C
T
G
S
--
Q
--
G
E
P
M
A
A
L
S
R
M
A
N
R
D
H
Q
-
I
R
I
V
N
G
D
T
V
I
L
A
-
S
S
L
I
P
G
N
E
-
N
A
-
V
Y
-
R
V
I
N
---------
G
--------------
L
T
R
-
W
G
----
A
N
V
V
H
-
K
G
--
N
A
K
-
V
-
H
V
S
G
H
A
S
A
G
E
L
L
Y
F
Y
N
I
C
R
--
P
K
N
L
M
P
V
H
G
E
W
R
H
L
R
A
N
A
E
L
-
G
-
A
L
T
G
V
P
---
H
D
R
I
V
I
A
E
D
G
V
V
V
D
L
V
E
G
K
A
K
I
T
G
K
V
Q
A
G
Y
V
Y
V
D
----------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
83.33
35%
-98
- C1 -
5A0T
4
?
A:
[16-455]
--------------------------------------------------------------------------------------------------------------------------------------------
K
G
G
L
R
V
T
P
L
G
G
L
G
E
I
G
R
N
M
T
V
F
E
Y
G
G
R
L
L
I
V
D
C
G
V
L
F
P
E
---------
E
E
Q
P
-----------
G
-------
I
-
D
--------
L
I
L
P
D
F
T
S
I
------------
R
D
R
L
D
D
I
---
E
G
I
V
L
T
H
G
H
E
D
H
I
G
G
V
P
F
L
L
-----
R
E
K-
P
-----
D
I
P
L
I
G
---
S
K
L
T
L
A
--------
L
I
E
A
K
L
Q
E
H
------------
R
-------------
I
----------
R
P
Y
T
L
E
V
A
E
G
H
R
E
R
V
-
G
-
P
-
F
D
C
E
F
V
A
V
N
H
S
I
P
D
A
L
A
V
A
I
R
T
--
P
--
A
G
M
V
V
H
T
G
D
F
K
M
-
D
Q
L
P
L
D
G
R
L
-------
T
D
L
H
A
F
---
A
R
L
S
E
E
G
I
D
L
L
L
A
D
S
T
N
A
E
V
P
G
F
--------
V
--
P
P
E
R
D
I
S
N
V
L
R
Q
V
F
A
---
N
---
A
-
R
K
R
-
I
I
V
A
S
F
A
S
H
V
H
R
I
Q
Q
I
L
D
A
A
H
E
Y
G
--------
R
-------
R
V
A
F
V
G
R
S
M
V
R
N
M
G
I
---
A
-
R
D
L
-
G
Y
L
K
V
P
-----------
P
---
G
---
L
---
V
V
D
V
------
K
------
T
L
--
D
D
--
L
P
D
S
E
V
V
L
V
C
T
G
S
--
Q
--
G
E
P
M
A
A
L
S
R
M
A
N
R
D
H
Q
-
I
R
I
V
N
G
D
T
V
I
L
A
-
S
S
L
I
P
G
N
E
-
N
A
-
V
Y
-
R
V
I
N
---------
G
--------------
L
T
R
-
W
G
----
A
N
V
V
H
-
K
G
--
N
A
K
-
V
-
H
V
S
G
H
A
S
A
G
E
L
L
Y
F
Y
N
I
C
R
--
P
K
N
L
M
P
V
H
G
E
W
R
H
L
R
A
N
A
E
L
-
G
-
A
L
T
G
V
P
---
H
D
R
I
V
I
A
E
D
G
V
V
V
D
L
V
E
G
K
A
K
I
T
G
K
V
Q
A
G
Y
V
Y
V
D
G
L
S
-------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
82.85
35%
-96
- C1 -
5A0V
3
?
A:
[16-455]
--------------------------------------------------------------------------------------------------------------------------------------------
K
G
G
L
R
V
T
P
L
G
G
L
G
E
I
G
R
N
M
T
V
F
E
Y
G
G
R
L
L
I
V
D
C
G
V
L
F
P
E
---------
E
E
Q
P
-----------
G
-------
I
-
D
--------
L
I
L
P
D
F
T
S
I
------------
R
D
R
L
D
D
I
---
E
G
I
V
L
T
H
G
H
E
D
H
I
G
G
V
P
F
L
L
-----
R
E
K-
P
-----
D
I
P
L
I
G
---
S
K
L
T
L
A
--------
L
I
E
A
K
L
Q
E
H
------------
R
-------------
I
----------
R
P
Y
T
L
E
V
A
E
G
H
R
E
R
V
-
G
-
P
-
F
D
C
E
F
V
A
V
N
H
S
I
P
D
A
L
A
V
A
I
R
T
--
P
--
A
G
M
V
V
H
T
G
D
F
K
M
-
D
Q
L
P
L
D
G
R
L
-------
T
D
L
H
A
F
---
A
R
L
S
E
E
G
I
D
L
L
L
A
D
S
T
N
A
E
V
P
G
F
--------
V
--
P
P
E
R
D
I
S
N
V
L
R
Q
V
F
A
---
N
---
A
-
R
K
R
-
I
I
V
A
S
F
A
S
H
V
H
R
I
Q
Q
I
L
D
A
A
H
E
Y
G
--------
R
-------
R
V
A
F
V
G
R
S
M
V
R
N
M
G
I
---
A
-
R
D
L
-
G
Y
L
K
V
P
-----------
P
---
G
---
L
---
V
V
D
V
------
K
------
T
L
--
D
D
--
L
P
D
S
E
V
V
L
V
C
T
G
S
--
Q
--
G
E
P
M
A
A
L
S
R
M
A
N
R
D
H
Q
-
I
R
I
V
N
G
D
T
V
I
L
A
-
S
S
L
I
P
G
N
E
-
N
A
-
V
Y
-
R
V
I
N
---------
G
--------------
L
T
R
-
W
G
----
A
N
V
V
H
-
K
G
--
N
A
K
-
V
-
H
V
S
G
H
A
S
A
G
E
L
L
Y
F
Y
N
I
C
R
--
P
K
N
L
M
P
V
H
G
E
W
R
H
L
R
A
N
A
E
L
-
G
-
A
L
T
G
V
P
---
H
D
R
I
V
I
A
E
D
G
V
V
V
D
L
V
E
G
K
A
K
I
T
G
K
V
Q
A
G
Y
V
Y
V
D
G
L
S
-------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
82.75
40%
-94
- C1 -
3BK2
7
RNJ_THET2
A:
[17-505]
-----------------------------------------------------------------------------------------------------------------------------------------------
V
E
I
I
P
L
G
G
M
G
E
I
G
K
N
I
T
V
F
R
F
R
D
E
I
F
V
L
D
G
G
L
A
F
P
E
---------
E
G
M
P
-----------
G
-------
V
-
D
--------
L
L
I
P
R
V
D
Y
L
------------
I
E
H
R
H
K
I
---
K
A
W
V
L
T
H
G
H
E
D
H
I
G
G
L
P
F
L
L
P
M
I
FG
K
E
--
S
-----
P
V
P
I
Y
G
---
A
R
L
T
L
G
--------
L
L
R
G
K
L
E
E
F
G
L
---------
R
P
-------------
G
----------
A
F
N
L
K
E
I
S
P
D
D
R
I
Q
V
-
G
-
R
Y
F
T
L
D
L
F
R
M
T
H
S
I
P
D
N
S
G
V
V
I
R
T
--
P
--
I
G
T
I
V
H
T
G
D
F
K
L
-
D
P
T
P
I
D
G
K
V
-------
S
H
L
A
K
V
---
A
Q
A
G
A
E
G
V
L
L
L
I
A
D
A
T
N
A
E
R
P
G
Y
--------
T
--
P
S
E
M
E
I
A
K
E
L
D
R
V
I
G
---
R
---
A
-
P
G
R
-
V
F
V
T
T
F
A
S
H
I
H
R
I
Q
S
V
I
W
A
A
E
K
Y
G
--------
R
-------
K
V
A
M
E
G
R
S
M
L
K
F
S
R
I
---
A
-
L
E
L
-
G
Y
L
K
V
K
-----------
D
---
R
---
L
---
Y
T
-
L
------
E
------
E
V
--
K
D
--
L
P
D
H
Q
V
L
I
L
A
T
G
S
--
Q
--
G
Q
P
M
S
V
L
H
R
L
A
F
E
G
H
A
K
M
A
I
K
P
G
D
T
V
I
L
S
-
S
S
P
I
P
G
N
E
-
E
A
-
V
N
-
R
V
I
N
---------
R
--------------
L
Y
A
-
L
G
----
A
Y
V
L
Y
-
P
P
--
T
Y
K
-
V
-
H
A
S
G
H
A
S
Q
E
E
L
K
L
I
L
N
L
T
T
--
P
R
F
F
L
P
W
H
G
E
V
R
H
Q
M
N
F
K
W
L
-
A
-
E
S
M
S
R
P
---
P
E
K
T
L
I
G
E
N
G
A
V
Y
R
L
T
R
E
T
F
E
K
V
G
E
V
P
H
G
V
L
Y
V
D
G
L
G
V
G
D
I
T
E
E
I
L
A
D
R
R
H
M
A
E
E
G
L
V
V
I
T
A
L
A
G
E
D
P
V
V
E
V
V
S
R
G
F
V
K
A
G
E
R
L
L
G
E
V
R
R
M
A
L
E
A
L
K
N
G
V
R
E
K
K
P
L
E
R
I
R
D
D
I
Y
Y
P
V
K
K
F
L
K
K
A
T
G
R
D
P
M
I
L
P
V
V
I
E
G
--------
6
PsiBlast_PDB
82.52
40%
-93
- C1 -
3BK1
7
RNJ_THET2
A:
[17-505]
-----------------------------------------------------------------------------------------------------------------------------------------------
V
E
I
I
P
L
G
G
M
G
E
I
G
K
N
I
T
V
F
R
F
R
D
E
I
F
V
L
D
G
G
L
A
F
P
E
---------
E
G
M
P
-----------
G
-------
V
-
D
--------
L
L
I
P
R
V
D
Y
L
------------
I
E
H
R
H
K
I
---
K
A
W
V
L
T
H
G
H
E
D
H
I
G
G
L
P
F
L
L
P
M
I
FG
K
E
--
S
-----
P
V
P
I
Y
G
---
A
R
L
T
L
G
--------
L
L
R
G
K
L
E
E
F
G
L
---------
R
P
-------------
G
----------
A
F
N
L
K
E
I
S
P
D
D
R
I
Q
V
-
G
-
R
Y
F
T
L
D
L
F
R
M
T
H
S
I
P
D
N
S
G
V
V
I
R
T
--
P
--
I
G
T
I
V
H
T
G
D
F
K
L
-
D
P
T
P
I
D
G
K
V
-------
S
H
L
A
K
V
---
A
Q
A
G
A
E
G
V
L
L
L
I
A
D
A
T
N
A
E
R
P
G
Y
--------
T
--
P
S
E
M
E
I
A
K
E
L
D
R
V
I
G
---
R
---
A
-
P
G
R
-
V
F
V
T
T
F
A
S
H
I
H
R
I
Q
S
V
I
W
A
A
E
K
Y
G
--------
R
-------
K
V
A
M
E
G
R
S
M
L
K
F
S
R
I
---
A
-
L
E
L
-
G
Y
L
K
V
K
-----------
D
---
R
---
L
---
Y
T
-
L
------
E
------
E
V
--
K
D
--
L
P
D
H
Q
V
L
I
L
A
T
G
S
--
Q
--
G
Q
P
M
S
V
L
H
R
L
A
F
E
G
H
A
K
M
A
I
K
P
G
D
T
V
I
L
S
-
S
S
P
I
P
G
N
E
-
E
A
-
V
N
-
R
V
I
N
---------
R
--------------
L
Y
A
-
L
G
----
A
Y
V
L
Y
-
P
P
--
T
Y
K
-
V
-
H
A
S
G
H
A
S
Q
E
E
L
K
L
I
L
N
L
T
T
--
P
R
F
F
L
P
W
H
G
E
V
R
H
Q
M
N
F
K
W
L
-
A
-
E
S
M
S
R
P
---
P
E
K
T
L
I
G
E
N
G
A
V
Y
R
L
T
R
E
T
F
E
K
V
G
E
V
P
H
G
V
L
Y
V
D
G
L
G
V
G
D
I
T
E
E
I
L
A
D
R
R
H
M
A
E
E
G
L
V
V
I
T
A
L
A
G
E
D
P
V
V
E
V
V
S
R
G
F
V
K
A
G
E
R
L
L
G
E
V
R
R
M
A
L
E
A
L
K
N
G
V
R
E
K
K
P
L
E
R
I
R
D
D
I
Y
Y
P
V
K
K
F
L
K
K
A
T
G
R
D
P
M
I
L
P
V
V
I
E
G
--------
4
PsiBlast_PDB
81.69
41%
-94
- C1 -
3T3N
2
RNJ_THET2
A:
[18-506]
-----------------------------------------------------------------------------------------------------------------------------------------------
V
E
I
I
P
L
G
G
M
G
E
I
G
K
N
I
T
V
F
R
F
R
D
E
I
F
V
L
D
G
G
L
A
F
P
E
---------
E
G
M
P
-----------
G
-------
V
-
D
--------
L
L
I
P
R
V
D
Y
L
------------
I
E
H
R
H
K
I
---
K
A
W
V
L
T
H
G
A
E
D
H
I
G
G
L
P
F
L
L
P
M
I
FG
K
E
--
S
-----
P
V
P
I
Y
G
---
A
R
L
T
L
G
--------
L
L
R
G
K
L
E
E
F
G
L
---------
R
P
-------------
G
----------
A
F
N
L
K
E
I
S
P
D
D
R
I
Q
V
-
G
-
R
Y
F
T
L
D
L
F
R
M
T
H
S
I
P
D
N
S
G
V
V
I
R
T
--
P
--
I
G
T
I
V
H
T
G
D
F
K
L
-
D
P
T
P
I
D
G
K
V
-------
S
H
L
A
K
V
---
A
Q
A
G
A
E
G
V
L
L
L
I
A
D
A
T
N
A
E
R
P
G
Y
--------
T
--
P
S
E
M
E
I
A
K
E
L
D
R
V
I
G
---
R
---
A
-
P
G
R
-
V
F
V
T
T
F
A
S
H
I
H
R
I
Q
S
V
I
W
A
A
E
K
Y
G
--------
R
-------
K
V
A
M
E
G
R
S
M
L
K
F
S
R
I
---
A
-
L
E
L
-
G
Y
L
K
V
K
-----------
D
---
R
---
L
---
Y
-
T
L
------
E
------
E
V
--
K
D
--
L
P
D
H
Q
V
L
I
L
A
T
G
S
--
Q
--
G
Q
P
M
S
V
L
H
R
L
A
F
E
G
H
A
K
M
A
I
K
P
G
D
T
V
I
L
S
-
S
S
P
I
P
G
N
E
-
E
A
-
V
N
-
R
V
I
N
---------
R
--------------
L
Y
A
-
L
G
----
A
Y
V
L
Y
-
P
P
--
T
Y
K
-
V
-
H
A
S
G
H
A
S
Q
E
E
L
K
L
I
L
N
L
T
T
--
P
R
F
F
L
P
W
H
G
E
V
R
H
Q
M
N
F
K
W
L
-
A
-
E
S
M
S
R
P
---
P
E
K
T
L
I
G
E
N
G
A
V
Y
R
L
T
R
E
T
F
E
K
V
G
E
V
P
H
G
V
L
Y
V
D
G
L
G
V
G
D
I
T
E
E
I
L
A
D
R
R
H
M
A
E
E
G
L
V
V
I
T
A
L
A
G
E
D
P
V
V
E
V
V
S
R
G
F
V
K
A
G
E
R
L
L
G
E
V
R
R
M
A
L
E
A
L
K
N
G
V
R
E
K
K
P
L
E
R
I
R
D
D
I
Y
Y
P
V
K
K
F
L
K
K
A
T
G
R
D
P
M
I
L
P
V
V
I
E
---------
5
PsiBlast_PDB
81.38
41%
-94
- C1 -
3T3O
3
RNJ_THET2
A:
[18-506]
-----------------------------------------------------------------------------------------------------------------------------------------------
V
E
I
I
P
L
G
G
M
G
E
I
G
K
N
I
T
V
F
R
F
R
D
E
I
F
V
L
D
G
G
L
A
F
P
E
---------
E
G
M
P
-----------
G
-------
V
-
D
--------
L
L
I
P
R
V
D
Y
L
------------
I
E
H
R
H
K
I
---
K
A
W
V
L
T
H
G
A
E
D
H
I
G
G
L
P
F
L
L
P
M
I
FG
K
E
--
S
-----
P
V
P
I
Y
G
---
A
R
L
T
L
G
--------
L
L
R
G
K
L
E
E
F
G
L
---------
R
P
-------------
G
----------
A
F
N
L
K
E
I
S
P
D
D
R
I
Q
V
-
G
-
R
Y
F
T
L
D
L
F
R
M
T
H
S
I
P
D
N
S
G
V
V
I
R
T
--
P
--
I
G
T
I
V
H
T
G
D
F
K
L
-
D
P
T
P
I
D
G
K
V
-------
S
H
L
A
K
V
---
A
Q
A
G
A
E
G
V
L
L
L
I
A
D
A
T
N
A
E
R
P
G
Y
--------
T
--
P
S
E
M
E
I
A
K
E
L
D
R
V
I
G
---
R
---
A
-
P
G
R
-
V
F
V
T
T
F
A
S
H
I
H
R
I
Q
S
V
I
W
A
A
E
K
Y
G
--------
R
-------
K
V
A
M
E
G
R
S
M
L
K
F
S
R
I
---
A
-
L
E
L
-
G
Y
L
K
V
K
-----------
D
---
R
---
L
---
Y
-
T
L
------
E
------
E
V
--
K
D
--
L
P
D
H
Q
V
L
I
L
A
T
G
S
--
Q
--
G
Q
P
M
S
V
L
H
R
L
A
F
E
G
H
A
K
M
A
I
K
P
G
D
T
V
I
L
S
-
S
S
P
I
P
G
N
E
-
E
A
-
V
N
-
R
V
I
N
---------
R
--------------
L
Y
A
-
L
G
----
A
Y
V
L
Y
-
P
P
--
T
Y
K
-
V
-
H
A
S
G
H
A
S
Q
E
E
L
K
L
I
L
N
L
T
T
--
P
R
F
F
L
P
W
H
G
E
V
R
H
Q
M
N
F
K
W
L
-
A
-
E
S
M
S
R
P
---
P
E
K
T
L
I
G
E
N
G
A
V
Y
R
L
T
R
E
T
F
E
K
V
G
E
V
P
H
G
V
L
Y
V
D
G
L
G
V
G
D
I
T
E
E
I
L
A
D
R
R
H
M
A
E
E
G
L
V
V
I
T
A
L
A
G
E
D
P
V
V
E
V
V
S
R
G
F
V
K
A
G
E
R
L
L
G
E
V
R
R
M
A
L
E
A
L
K
N
G
V
R
E
K
K
P
L
E
R
I
R
D
D
I
Y
Y
P
V
K
K
F
L
K
K
A
T
G
R
D
P
M
I
L
P
V
V
I
E
---------
35
HHSearch
51.88
18%
-80
- C1 -
2I7T
3
CPSF3_HUMAN
A:
[9-457]
--------------------------------------------------------------------------------------------------------------------------------------------
S
D
Q
L
L
I
R
P
L
G
A
G
Q
E
V
G
R
S
C
I
I
L
E
F
K
G
R
K
I
M
L
D
C
G
I
H
P
G
L
---------
E
G
---------------------
M
-
D
---------
A
L
P
Y
I
D
L
I
--------------
D
P
A
E
I
---
D
L
L
L
I
S
H
F
H
L
D
H
C
G
A
L
P
W
F
L
-----
Q
K
--
T
SF---
K
G
R
T
F
M
---
T
H
A
T
K
A
--------
I
Y
R
W
L
L
S
D
Y
V
K
-----------LYT
E
T
D
L
E
E
S
---
M
----------
D
K
I
-
E
T
I
N
F
H
E
V
K
E
V
-
A
-
G
-
I
K
F
W
C
Y
H
A
G
H
-
V
L
G
A
A
M
F
M
I
E
I
--
A
--
G
V
K
L
L
Y
T
G
D
F
S
R
-
Q
-----
M
A
--------
A
E
---------
I
P
N
I
K
P
D
I
L
I
I
E
S
T
Y
G
T
H
I
H
E
--------
K
R
E
E
R
E
A
R
F
C
N
T
V
H
D
I
V
----
N
---
R
-
G
G
R
-
G
L
I
P
V
F
A
--
L
G
R
A
Q
E
L
L
L
I
L
D
E
Y
W
Q
N
H
PELHD
I
-------
P
I
Y
Y
A
------------------------------------------------
F
K
H
I
S
N
L
---
K
------
S
M
DH
F
D
--
D
I
G
P
S
V
V
M
A
S
P
G
M
--
M
QS
G
L
S
R
E
L
F
E
S
--------
W
C
T
D
K
R
N
G
V
I
I
A
-
G
Y
C
V
E
G
T
L
-
A
K
-
H
I
M
S
E
P
E
---------
E
--------------
I
T
T
M
S
G
----
Q
K
L
P
L
K
M
S
--
V
D
Y
-
I
-
S
F
S
A
H
T
D
Y
Q
Q
T
S
E
F
I
R
A
L
K
--
P
P
H
V
I
L
V
H
G
E
Q
N
E
M
A
R
L
K
A
A
L
I
-
R
E
Y
E
D
N
DE
V
H
I
E
V
H
N
P
R
N
T
E
A
V
T
L
N
F
R
--------------------------------------------------------------------------------------------------------------------------------
36
HHSearch
48.43
22%
-76
- C1 -
2AZ4
2
?
A:
[5-428]
---------------------------------------------------------------------------------------------------------------------------------------------
A
K
T
T
V
T
F
H
S
G
I
L
T
I
G
G
T
V
I
E
V
A
Y
K
D
A
H
I
F
F
D
F
G
T
E
F
R
P
---------
E
L
D
L
P----------
D
DH
I
E
T
L
I
N
-
N
--------
R
L
V
P
E
L
K
D
L
YDPRLG
Y
E
Y
H
G
A
E
D
K
D
Y
Q
H
---
T
A
V
F
L
S
H
A
H
L
D
H
S
R
M
I
N
Y
L
D
-----
P
A
---------
V
P
L
Y
T
---
L
K
E
T
K
M
--------
I
L
N
S
L
N
R
K
G
D
F
LIPSPFEEK
N
F
-------------
T
----------
R
E
M
-
I
G
L
N
K
N
D
V
I
K
V
-
G
-
E
-
I
S
V
E
I
V
P
V
D
H
D
A
Y
G
A
S
A
L
L
I
R
T
--
P
--
D
H
F
I
T
Y
T
G
D
L
R
L
-
H
G
H
N
R
E
-----------
E
T
L
A
F
---
C
E
K
-
A
K
H
T
E
L
L
M
M
E
G
V
S
I
S
F
P
E
R
EPDPAQIA
V
--
V
S
E
E
D
L
V
Q
H
L
V
R
L
E
L
---
E
---
N
P
N
R
Q
-
I
T
F
N
G
Y
P
A
N
V
E
R
F
A
K
I
I
E
---
K
S
P
--------
R
-------
T
V
V
L
E
A
N
M
A
A
L
L
L
E
V
FG
I
E
-
V
R
Y
-
Y
Y
A
E
-------------
S
---
G
---
K
---
I
P
E
L
------
N
------
P
A
--
L
E
--
I
P
Y
D
T
L
L
K
---
D
K
--
T
--
D
Y
L
W
Q
V
V
N
Q
F
-------
D
N
L
Q
E
G
S
L
Y
I
H
S
-
D
A
Q
P
L
G
D
F
-
D
P
Q
Y
R
-
V
F
L
D
---------
L
--------------
L
A
K
-
K
D
----
I
T
F
V
--------
R
-
L
-
A
C
S
G
H
A
I
P
E
D
L
D
K
I
I
A
L
I
E
--
P
Q
V
L
V
P
I
H
T
L
K
P
E
K
--
L
E
N
P
-
Y
-
G
---------
E
R
I
-
L
P
E
R
G
E
Q
I
V
L
-----------------------------------------------------------------------------------------------------------------------------------
34
HHSearch
48.04
19%
-82
* C1 *
3IEK
22
RNSE_THET8
A:
[1-431]
-----------------------------------------------------------------------------------------------------------------------------------------------
M
R
I
V
P
F
G
A
A
R
E
V
T
G
S
A
H
L
L
L
A
G
G
R
R
V
L
L
D
C
G
M
F
Q
G
K
---------
E
E
A
R
-------------------------------
N
H
A
P
F
---------------
G
F
D
P
K
E
V
---
D
A
V
L
L
T
H
A
H
L
D
H
V
G
R
L
P
K
L
F
-----
R
E
G-
Y
-----
R
G
P
V
Y
A
---
T
R
A
T
V
L
--------
L
M
E
I
V
L
E
D
A
L
K
---------
V
M
DEPFFG
P
E
D
V
E
E
A
L
----------
G
H
L
-
R
P
L
E
Y
G
E
W
L
R
L
-
G
-
A
-
L
S
L
A
F
G
Q
A
G
H
-
L
P
G
S
A
F
V
V
A
Q
G
--
E
--
G
R
T
L
V
Y
S
G
D
L
G
N
-
R
E
K
D
V
L
P
D
--------
P
S
L
P
----------
P
L
A
D
L
V
L
A
E
G
T
Y
G
D
R
P
H
R
--------
P
Y
R
E
T
V
R
E
F
L
E
I
L
E
K
T
L
----
S
---
Q
-
G
G
K
-
V
L
I
P
T
F
A
--
V
E
R
A
Q
E
I
L
Y
V
L
Y
T
H
G
HRL
P
R
---
A
-------
P
I
Y
L
D
S
P
M
A
G
R
V
L
S
L
---
Y
-
P
R
L
V
R
Y
F
S
E
E
V
Q
A
H
F
L
Q
GKN-
P
---
F
---
R
PAG
L
E
V
V
------
E
H
T
E
A
S
K
A
L
--
N
R
--
A
P
G
P
M
V
V
L
A
G
S
G
M
--
L
AG
G
R
I
L
H
H
L
K
H
G
--------
L
S
D
P
R
N
A
L
V
F
V
-
G
Y
Q
P
Q
G
G
L
-
G
A
----
E
I
I
A
RPP
A
V
R
I
LG
E
--------------
E
V
P
-
L
R
----
A
S
V
--------
H
T
-
L
G
G
F
S
G
H
A
G
Q
D
E
L
L
D
W
L
Q
--
G
--
E
P
R
V
V
L
V
H
G
E
E
E
K
L
L
A
L
G
K
L
-
L
-
A
L
R
G
Q
E
------
V
S
L
A
R
F
G
E
G
V
P
V
-----------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
47.56
17%
-56
- C1 -
2YCB
7
?
A:
[131-636]
--------------------------------------------------------------------------------
P
K
I
L
R
T
P
P
I
S
S
E
I
I
E
R
I
R
R
T
L
R
K
N
S
K
E
R
K
K
I
L
Q
------
Q
L
G
N
R
I
H
Q
K
P
K
Y
D
--------
N
D
W
A
R
L
T
A
M
G
G
F
R
E
V
G
R
S
C
L
Y
L
Q
T
P
N
S
R
V
L
L
D
C
G
V
N
V
A
G
---------
G
D
D
----------------------
K
--------
N
S
Y
P
Y
L
N
V
P
------------
E
F
T
L
D
S
L
---
D
A
V
I
I
T
H
A
H
L
D
H
S
G
F
L
P
Y
L
Y
-----
H
Y
G-
Y
-----
D
G
P
V
Y
C
---
T
A
P
T
R
D
--------
L
M
T
L
L
Q
L
D
H
I
D
---------
I
A
H
R
E
DEPL------
P
FN
V
K
H
V
K
K
S
V
K
H
T
-
I
T
L
D
Y
G
E
V
T
D
I
A
P
-
D
-
I
R
L
T
L
H
N
A
G
H
-
I
L
G
S
A
M
A
H
L
H
I
GD
G
--
Q
H
N
M
V
Y
T
G
D
F
K
Y
-
E
Q
S
R
L
L
E
A
A
-------
A
--
N
--------
R
F
P
R
I
E
T
L
V
M
E
S
T
Y
G
G
H
E
D
V
--------
Q
--
P
S
R
N
R
A
E
K
E
L
V
K
T
I
Y
S
T
L
R
---
R
-
G
G
K
-
I
L
I
P
V
F
A
--
V
G
R
A
Q
E
L
M
I
V
L
E
E
Y
I
--------
R
T
GIIDE
V
P
V
Y
I
D
G
M
-
I
W
E
A
N
A
I
---
H
-
T
A
R
P
E
Y
L
S
K
D
L
R
D
Q
I
FHMGHN
P
---
F
ISD
I
---
F
H
K
V
N
G
M
---
D
------
E
R
--
R
E
I
V
E
G
E
P
S
I
I
L
S
T
S
G
M
LT
G
--
G
N
S
L
E
Y
F
K
W
L
--------
C
E
D
P
D
N
S
L
V
F
V
-
G
Y
Q
A
E
G
S
L
-
G
R
-
R
I
---
Q
K
---------
G
WK
E
I
P
L
K
D
EDD
K
M
R
V
Y
N
-
V
R
----
M
N
I
--------
K
T
-
I
E
G
F
S
G
H
S
D
R
R
Q
L
M
E
Y
V
K
R
I
S
PK
P
E
K
I
L
L
C
H
G
D
N
Y
K
T
L
D
L
A
S
S
-
I
-
Y
R
T
Y
-
R
----
I
E
T
K
T
P
L
N
L
E
T
V
R
I
Q
----------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
46.51
22%
-76
- C1 -
2AZ4
2
?
A:
[5-404]
---------------------------------------------------------------------------------------------------------------------------------------------
A
K
T
T
V
T
F
H
S
G
I
L
T
I
G
G
T
V
I
E
V
A
Y
K
D
A
H
I
F
F
D
F
G
T
E
F
R
P
---------
E
L
D
L
-----------
P
-------
D
-
D
H
I
E
T
L
I
N
N
R
L
V
P
E
L
K
D
L
YDPRLG
Y
E
Y
---
H
G
A
E
D
K
D
YQ
H
T
A
V
F
L
S
H
A
H
L
D
H
S
R
M
I
N
Y
L
-------
D
--
P
-----
A
V
P
L
Y
T
L
K
E
T
K
M
I
L
N
S
L
N
R
KGDF
L
I
P
S
P
F
E
E
------------
K
N
-------------
F
----------
T
R
E
M
I
G
L
N
K
N
D
V
I
K
V
-
G
-
E
-
I
S
V
E
I
V
P
V
D
H
D
A
Y
G
A
S
A
L
L
I
R
T
--
P
--
D
H
F
I
T
Y
T
G
D
L
R
L
H
G
H
N
R
E
E
T
L
A
F
C
E
K
A
KH
T
E
L
L
M
M
--------
E
G
V
S
I
S
F
P
E
R
E
P
D
P
A
Q
I
A
--------
V
--
V
S
E
E
D
L
V
Q
H
L
V
R
L
E
L
---
E
---
N
-
P
N
R
Q
I
T
F
N
G
Y
P
A
N
V
E
R
F
A
K
I
I
E
---
K
S
P
--------
R
-------
T
V
V
L
E
A
N
M
A
A
L
L
L
E
V
F--
G
-
I
E
V
-
R
Y
Y
Y
A
E
-----------
S
---
G
---
K
---
I
P
E
L
------
N
------
P
A
--
L
E
--
I
P
Y
D
T
L
L
-----------
K
D
K
T
D
Y
L
W
Q
V
V
---
N
Q
F
D
N
L
Q
E
G
S
L
Y
I
H
S
D
A
Q
P
L
G
D
F
D
-
P
Q
-
Y
R
-
V
F
L
D
---------
L
--------------
L
A
K
-
K
D
----
I
T
--------
F
V
R
-
L
-
A
C
S
G
H
A
I
P
E
D
L
D
K
I
I
A
L
I
E
--
P
Q
V
L
V
P
I
H
T
L
K
P
E
K
L
E
N
P
Y
G
-
E
-
R
I
L
P
E
R
---
G
E
Q
I
V
L
--------------------------------------------------------------------------------------------------------------------------------------------
32
HHSearch
46.16
18%
-62
- C1 -
3AF5
13
?
A:
[140-650]
--------------------------------------------------------------------------------
P
K
V
V
R
T
P
P
L
Q
S
Q
T
I
Y
S
I
R
Q
I
L
Q
T
E
S
K
D
R
R
K
F
L
R
------
Q
V
G
R
N
I
Y
R
K
P
E
Y
K
--------
S
R
W
I
R
I
T
G
L
G
G
F
R
E
V
G
R
S
A
L
L
V
Q
T
D
E
S
F
V
L
V
D
F
G
V
N
V
A
M
---------
L
N
D
P
Y
K
---------
A
-------
F
P
H
--------
F
D
A
P
E
F
Q
Y
V
------------
L
-
R
E
G
L
L
---
D
A
I
I
I
T
H
A
H
L
D
H
C
G
M
L
P
Y
L
F
-----
R
Y
NL
F
-----
D
G
P
I
Y
T
---
T
P
P
T
R
D
--------
L
M
V
L
L
Q
K
D
F
I
E
---------
I
Q
Q
S
N
GQDPLYR
P
R
-
D
I
K
E
V
I
-----
K
H
T
-
I
T
L
D
Y
G
E
V
R
D
I
-
S
P
D
-
I
R
L
T
L
H
N
A
G
H
-
I
L
G
S
A
I
V
H
L
H
I
--
G
NG
L
H
N
I
A
I
T
G
D
F
K
F
-
I
P
T
R
L
L
E
P
A
-------
N
--
A
--------
K
F
P
R
L
E
T
L
V
M
E
S
T
Y
G
G
A
N
D
I
--------
Q
--
M
P
R
E
E
A
E
K
R
L
I
E
V
I
H
---
N
T
I
K
R
-
G
G
K
-
V
L
I
P
A
M
A
--
V
G
R
A
Q
E
V
M
M
V
L
E
E
Y
A
--------
R
I
GGIE
V
-
P
I
Y
L
D
G
M
-
I
W
E
A
T
A
I
---
H
-
T
A
Y
P
E
Y
L
S
R
R
L
R
E
Q
I
FKEGYN
P
FLS
E
---
I
---
F
H
P
V
AN
S
R
E
R
Q
------
D
I
--
I
D
--
S
N
E
P
A
I
I
I
A
S
S
G
M
LV
G
--
G
P
S
V
E
Y
F
K
Q
L
--------
A
P
D
P
K
N
S
I
I
F
V
-
S
Y
Q
A
E
G
T
L
-
G
R
-
Q
V
Q
S
G
I
R
---------
E
--------------
I
P
M
-
V
G
EEG
R
T
E
V
I
K
-
V
N
M
E
V
H
T
I
D
-
G
F
S
G
H
A
D
R
R
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L
M
N
Y
V
A
K
V
R
PR
P
E
R
I
I
T
V
H
G
E
P
Q
K
C
L
D
L
A
T
S
-
I
H
R
K
F
G
I
------
S
T
R
A
P
N
N
L
D
T
I
R
L
R
----------------------------------------------------------------------------------------------------------------------------------
52
Fugue
40.77
20%
-66
- C1 -
2AZ4
2
?
A:
[5-429]
---------------------------------------------------------------------------------------------------------------------------------------------
A
K
T
T
V
T
F
H
S
G
I
L
T
I
G
G
T
V
I
E
V
A
Y
K
D
A
H
I
F
F
D
F
G
T
E
F
R
P
ELDLPDDH
I
E
T
L
I
N
N
RLVPELKDL
Y
-------
D
-
P
--------
R
L
G
Y
E
Y
H
G
A
------------
E
D
K
D
Y
Q
H
---
T
A
V
F
L
S
H
A
H
L
D
H
S
R
M
I
N
Y
L
D
-----
P
A
--
V
-------
P
L
Y
T
---
L
K
E
T
K
M
--------
I
L
N
S
L
N
R
K
G
D
F
LIPSPFEE-
K
N
-------------
F
----------
T
R
E
M
I
G
L
N
K
N
D
V
I
K
V
-
G
-
E
-
I
S
V
E
I
V
P
V
D
H
D
A
Y
G
A
S
A
L
L
I
R
T
--
P
--
D
H
F
I
T
Y
T
G
D
L
R
L
-
H
G
H
N
R
E
E
T
L
-------
A
F
C
E
K
A
KHT
E
L
L
M
M
E
G
V
S
I
S
F
P
E
R
E
P
D
P
A
Q
I
A
--------
V
--
V
S
E
E
D
L
V
Q
H
L
V
R
L
E
L
---
E
N
--
P
-
N
R
Q
-
I
T
F
N
G
Y
P
A
N
V
E
R
F
A
K
I
I
E
K
---
S
P
--------
R
-------
T
V
V
L
E
A
N
M
A
A
L
L
L
E
V
---
F
G
I
E
V
-
R
Y
Y
Y
A
E
-----------
S
---
G
---
K
---
I
P
E
L
------
N
------
P
A
--
L
E
--
I
P
Y
D
T
L
L
K
D
K
T
D
Y
--
L
--
W
Q
V
V
N
Q
F
D
N
L
Q
----------
E
G
S
L
Y
I
H
S
-
D
A
Q
P
L
G
D
F
D
P
Q
-
Y
R
-
V
F
L
D
---------
L
--------------
L
A
K
-
K
D
----
I
T
F
V
R
---------
L
-
A
C
S
G
H
A
I
P
E
D
L
D
K
I
I
A
L
I
E
--
P
Q
V
L
V
P
I
H
T
L
K
P
E
K
L
E
N
-----------
P
---
Y
G
E
R
I
L
P
E
R
G
E
Q
I
V
L
-----------------------------------------------------------------------------------------------------------------------------------