@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_1354: (2015-12-23 )
MKKTILLSALLAFSCAHALSDMDLIKKAKESQLEPMPMGKALKEYQIKKTRDVGIGAKNSEIMTSAQVELGKMLYFDPRISTSYLVSCNTCHNLGLGGVDLIPSAIGSQWKKNPHLLSSPTVYNSVFNDVQFWDGRVTHLNEQAQGPIQSSFEMGADPKVVVEKINSIPGYVKLFRKAYGSKVKIDFKLIADSIAMFEATLITPSRYDDFLRGNPKALSKAEKEGLDLFISKGCVACHNGINLGGTMQPFGVVKPYKFANVGDFKGDKNGLVKVPTLRNITETMPYFHNGQFWDVKDAIKEMGSIQLGIEISDAEAKKIETFFEALKGKKPKIIYPELPVMTDKTPKPSF
Atome Classification :
(25 SA)
.........10........20.---.......30........40........50........60......------..70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......-180-.-.-.....190.......200..-.....210.......220.......230.......240...-.-.-.-.250-------.-..-----..------..260-....----.-----....--270----.........280.......290.......300.......310.......320.......330.......340.......350
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MK
K
T
I
L
L
S
A
L
L
A
F
S
C
A
H
A
L
S
D
M
---
D
L
I
K
K
A
K
ESQLEPM
P
M
G
K
A
L
K
E
YQIKKTRDVGIGAKNS
E
I
M
T
S
A
Q
------
V
E
L
G
K
M
L
Y
FDPRIS
T
S
Y
L
V
SCNTCHNLGLG
G
V
D
L
I
P
S
A
I
G
S
Q
WKKNPHLLSSP
T
V
Y
N
S
V
FNDVQFWD
G
R
V
TH
L
N
E
QAQGP
I
Q
S
SFEMGAD
P
K
V
V
V
E
K
I
NSI
P
G
Y
V
K
L
F
R
K
AY-G
S
K
-
V
-
K
-
I
D
F
K
L
I
A
D
S
I
A
M
F
E
A
T
LI
T
P
-
S
R
Y
D
D
F
LRG
N
P
K
A
L
S
K
A
E
KEG
L
D
L
F
I
SKG
C
V
A
C
HNGINLGG-T-M-Q-PFGV-------V-K
P
-----
Y
K
------FAN---VGDF----K-----GDKN--
G
------
L
V
KVP
T
L
R
N
I
T
E
TMPYFHN
G
Q
FW
D
V
K
D
A
I
K
EMG
S
I
Q
L
G
I
E
ISDA
E
A
K
K
I
E
T
F
F
E
A
LKGKKP
K
I
IYPELPVMTDKTPKPSF-
27
PsiBlast_CBE
91.55
44%
-52
- C5 -
2C1V
5
?
B:
[28-336]
-------------------------------------------------
I
K
Q
T
E
D
N
P
E
G
V
P
----
L
T
A
E
K
------
I
E
L
G
K
V
L
F
F
D
P
R
M
S
S
S
G
L
I
S
C
Q
T
C
H
N
V
G
L
G
G
V
D
G
L
P
T
S
I
G
H
G
W
Q
K
G
P
R
--
N
A
P
T
M
L
N
A
I
F
N
A
A
Q
F
W
D
G
R
A
A
D
L
A
E
Q
A
K
G
P
V
Q
A
G
V
E
M
S
N
T
P
D
Q
V
V
K
T
I
N
S
M
P
E
Y
V
E
A
F
K
A
A
F
-
P
E
E
-
A
-
D
P
V
T
F
D
N
F
A
A
A
I
E
Q
F
E
A
T
L
I
T
P
N
S
A
F
D
R
F
L
A
G
D
D
A
A
M
T
D
Q
E
K
R
G
L
Q
A
F
M
E
T
G
C
T
A
C
H
Y
G
V
N
F
G
G
-
Q
D
Y
-
H
-
P
F
G
L
-------
I
A
K
P
GAEV-
L
P
------
A
G
D
---
T
G
R
F
----
E
VTRT-
T
D
D
E
--
Y
------
V
F
R
A
A
P
L
R
N
V
A
L
T
A
P
Y
F
H
S
G
V
V
W
E
L
A
E
A
V
K
I
M
S
S
A
Q
I
G
T
E
L
T
D
Q
Q
A
E
D
I
T
A
F
L
G
T
L
T
G
E
Q
P
V
I
D
H
P
I
L
P
V
R
T
G
T
T
P
L
P
T
P
-
12
PsiBlast_PDB
91.44
44%
-51
- C5 -
2C1V
5
?
A:
[28-336]
-------------------------------------------------
I
K
Q
T
E
D
N
P
E
G
V
P
----
L
T
A
E
K
------
I
E
L
G
K
V
L
F
F
D
P
R
M
S
S
S
G
L
I
S
C
Q
T
C
H
N
V
G
L
G
G
V
D
G
L
P
T
S
I
G
H
G
W
Q
K
G
P
R
--
N
A
P
T
M
L
N
A
I
F
N
A
A
Q
F
W
D
G
R
A
A
D
L
A
E
Q
A
K
G
P
V
Q
A
G
V
E
M
S
N
T
P
D
Q
V
V
K
T
I
N
S
M
P
E
Y
V
E
A
F
K
A
A
F
-
P
E
E
-
A
-
D
P
V
T
F
D
N
F
A
A
A
I
E
Q
F
E
A
T
L
I
T
P
N
S
A
F
D
R
F
L
A
G
D
D
A
A
M
T
D
Q
E
K
R
G
L
Q
A
F
M
E
T
G
C
T
A
C
H
Y
G
V
N
F
G
G
-
Q
D
Y
-
H
-
P
F
G
L
-------
I
A
K
P
GAEV-
L
P
------
A
G
D
---
T
G
R
F
----
E
VTRT-
T
D
D
E
--
Y
------
V
F
R
A
A
P
L
R
N
V
A
L
T
A
P
Y
F
H
S
G
V
V
W
E
L
A
E
A
V
K
I
M
S
S
A
Q
I
G
T
E
L
T
D
Q
Q
A
E
D
I
T
A
F
L
G
T
L
T
G
E
Q
P
V
I
D
H
P
I
L
P
V
R
T
G
T
T
P
L
P
T
P
-
51
HHSearch
91.13
46%
-44
- C5 -
2VHD
3
CCPR_PSEAE
A:
[8-322]
--------------------------------
S
A
L
F
K
P
I
P
E
Q
V
T
E
---------------
L
R
G
Q
P
I
S
E
Q
Q
------
R
E
L
G
K
K
L
F
F
D
P
R
L
S
R
S
H
V
L
S
C
N
T
C
H
N
V
G
T
G
G
A
D
N
V
P
T
S
V
G
H
G
W
Q
K
G
P
--
R
N
S
P
T
V
F
N
A
V
F
N
A
A
Q
F
W
D
G
R
A
K
D
L
G
E
Q
A
K
G
P
I
Q
N
S
V
E
M
H
S
T
P
Q
L
V
E
Q
T
L
G
S
I
P
E
Y
V
D
A
F
R
K
A
F
-
P
K
A
-
G
K
P
-
V
S
F
D
N
M
A
L
A
I
E
A
Y
E
A
T
L
V
T
P
D
S
P
F
D
L
Y
L
K
G
D
D
K
A
L
D
A
Q
Q
K
K
G
L
K
A
F
M
D
S
G
C
S
A
C
H
N
G
I
N
L
G
G
-
Q
A
Y
-
F
-
P
F
G
L
-------
V
-
K
K
PDASV
L
P
------
S
G
D
---
K
G
R
F
AVTK
T
-----
Q
S
D
E
--
Y
------
V
F
R
A
A
P
L
R
N
V
A
L
T
A
P
Y
F
H
S
G
Q
V
W
E
L
K
D
A
V
A
I
M
G
N
A
Q
L
G
K
Q
L
A
P
D
D
V
E
N
I
V
A
F
L
H
S
L
S
G
K
Q
P
R
V
E
Y
P
L
L
P
A
S
T
E
T
T
P
R
P
A
E
-
2
PsiBlast_PDB
90.62
46%
-55
- C5 -
3HQ6
3
?
A:
[22-343]
----------------------A--
D
E
L
Q
Q
R
A
Q
G
L
F
K
P
V
P
A
----
K
A
P
T
L
K
-------
G
N
P
A
S
P
V
----
K
------
V
E
L
G
K
M
L
Y
F
D
P
R
L
S
A
S
H
L
I
S
C
N
T
C
H
N
V
G
L
G
G
G
D
L
Q
A
T
S
T
G
H
G
W
Q
K
G
P
R
--
N
A
P
T
V
L
N
S
V
F
N
T
A
Q
F
W
D
G
R
A
K
D
L
A
E
Q
A
K
G
P
V
Q
A
S
V
E
M
N
N
T
P
D
Q
V
V
K
T
L
N
S
I
P
D
Y
V
A
L
F
K
K
A
F
P
G
E
K
-
D
-
P
-
V
T
F
D
N
M
A
K
A
I
E
V
F
E
A
T
L
I
T
P
D
S
P
F
D
Q
Y
L
K
G
K
K
K
A
L
D
G
K
Q
T
A
G
L
K
L
F
L
D
K
G
C
V
A
C
H
G
G
L
N
L
G
G
-
T
-
G
-
Y
F
P
F
G
V
-------
V
E
K
P
-----
A
E
NILP--
L
G
D
---
K
G
R
F
----
A
-----
V
T
N
T
--
A
KDE
Y
--
V
F
R
A
P
S
L
R
N
V
A
I
T
Y
P
Y
F
H
S
G
V
V
W
S
L
K
E
A
V
A
V
M
G
S
A
Q
F
G
I
K
L
S
D
D
E
S
E
A
I
A
A
F
L
G
S
L
T
G
K
Q
P
K
V
V
Y
P
I
M
P
A
S
T
D
A
T
P
R
P
R
L
-
38
Fugue
90.49
44%
-55
- C5 -
1EB7
3
CCPR_PSEAE
A:
[1-323]
-------------------------
D
A
L
H
D
Q
A
S
A
L
F
K
P
I
P
E
Q
V
T
E
L
R
---------------
G
Q
P
I
S
E
Q
Q
------
R
E
L
G
K
K
L
F
F
D
P
R
L
S
R
S
H
V
L
S
C
N
T
C
H
N
V
G
T
G
G
A
D
N
V
P
T
S
V
G
H
G
W
Q
K
G
P
R
--
N
S
P
T
V
F
N
A
V
F
N
A
A
Q
F
W
D
G
R
A
K
D
L
G
E
Q
A
K
G
P
I
Q
N
S
V
E
M
H
S
T
P
Q
L
V
E
Q
T
L
G
S
I
P
E
Y
V
D
A
F
R
K
A
F
-
P
K
A
G
K
-
P
-
V
S
F
D
N
M
A
L
A
I
E
A
Y
E
A
T
L
V
T
P
D
S
P
F
D
L
Y
L
K
G
D
D
K
A
L
D
A
Q
Q
K
K
G
L
K
A
F
M
D
S
G
C
S
A
C
H
N
G
I
N
L
G
G
Q
A
-
Y
-
F
-
P
F
G
L
-------
V
-
K
K
-----
P
D
ADKGR
F
A
V
T
---
K
T
Q
--------------
S
DE
Y
------
V
F
R
A
A
P
L
R
N
V
A
L
T
A
P
Y
F
H
S
G
Q
V
W
E
L
K
D
A
V
A
I
M
G
N
A
Q
L
G
K
Q
L
A
P
D
D
V
E
N
I
V
A
F
L
H
S
L
S
G
K
Q
P
R
V
E
Y
P
L
L
P
A
S
T
E
T
T
P
R
P
A
-E
22
PsiBlast_CBE
90.35
45%
-59
- C5 -
3HQ9
10
?
B:
[21-343]
----------------------A
A
-
D
E
L
Q
Q
R
A
Q
G
L
F
K
P
V
P
A
----
K
A
P
T
L
K
-----------
G
N
P
A
S
P
V
K
------
V
E
L
G
K
M
L
Y
F
D
P
R
L
S
A
S
H
L
I
S
C
N
T
C
H
N
V
G
L
G
G
G
D
L
Q
A
T
S
T
G
H
G
W
Q
K
G
P
R
--
N
A
P
T
V
L
N
S
V
F
N
T
A
Q
F
W
D
G
R
A
K
D
L
--------
Q
A
P
V
E
M
N
N
T
P
D
Q
V
V
K
T
L
N
S
I
P
D
Y
V
A
L
F
K
K
A
F
P
G
E
K
-
D
-
P
-
V
T
F
D
N
M
A
K
A
I
E
V
F
E
A
T
L
I
T
P
D
S
P
F
D
Q
Y
L
K
G
K
K
K
A
L
D
G
K
Q
T
A
G
L
K
L
F
L
D
K
G
C
V
A
C
H
G
G
L
N
L
G
G
-
T
-
G
-
Y
F
P
F
G
V
-------
V
E
K
---------------------
G
R
F
----
A
-----
V
T
N
T
--
A
KDE
Y
--
V
F
R
A
P
S
L
R
N
V
A
I
T
Y
P
Y
F
H
S
G
V
V
W
S
L
K
E
A
V
A
V
M
G
S
A
Q
F
G
I
K
L
S
D
D
E
S
E
A
I
A
A
F
L
G
S
L
T
G
K
Q
P
K
V
V
Y
P
I
M
P
A
S
T
D
A
T
P
R
P
R
L
-
39
Fugue
90.26
44%
-51
- C5 -
1EB7
3
CCPR_PSEAE
A:
[1-323]
-------------------------
D
A
L
H
D
Q
A
S
A
L
F
K
P
I
P
E
Q
V
T
E
L
R
---------------
G
Q
P
I
S
E
Q
Q
------
R
E
L
G
K
K
L
F
F
D
P
R
L
S
R
S
H
V
L
S
C
N
T
C
H
N
V
G
T
G
G
A
D
N
V
P
T
S
V
G
H
G
W
Q
K
G
P
R
--
N
S
P
T
V
F
N
A
V
F
N
A
A
Q
F
W
D
G
R
A
K
D
L
G
E
Q
A
K
G
P
I
Q
N
S
V
E
M
H
S
T
P
Q
L
V
E
Q
T
L
G
S
I
P
E
Y
V
D
A
F
R
K
A
F
-
P
K
A
G
K
-
P
-
V
S
F
D
N
M
A
L
A
I
E
A
Y
E
A
T
L
V
T
P
D
S
P
F
D
L
Y
L
K
G
D
D
K
A
L
D
A
Q
Q
K
K
G
L
K
A
F
M
D
S
G
C
S
A
C
H
N
G
I
N
L
G
G
Q
A
-
Y
-
F
-
P
F
G
L
-------
V
-
K
K
-----
P
D
------
A
D
K
GR
F
A
V
T
K
----
T
-----
Q
S
D
E
--
Y
------
V
F
R
A
A
P
L
R
N
V
A
L
T
A
P
Y
F
H
S
G
Q
V
W
E
L
K
D
A
V
A
I
M
G
N
A
Q
L
G
K
Q
L
A
P
D
D
V
E
N
I
V
A
F
L
H
S
L
S
G
K
Q
P
R
V
E
Y
P
L
L
P
A
S
T
E
T
T
P
R
P
A
E
-
8
PsiBlast_PDB
90.17
46%
-65
- C5 -
1RZ5
3
?
A:
[26-321]
-----------------------------------------------------------------
L
T
Q
A
K
------
V
E
L
G
K
M
E
F
F
E
P
R
L
S
S
S
H
L
I
S
C
N
T
C
H
N
V
G
L
G
G
D
D
E
L
P
T
S
I
G
H
G
W
Q
K
G
P
R
--
N
S
P
T
V
F
N
A
V
F
N
A
A
Q
F
W
D
G
R
-------
A
K
G
P
V
Q
A
G
V
E
M
S
S
T
P
D
R
V
V
A
T
L
K
S
M
P
E
Y
I
E
R
F
E
D
A
F
P
G
Q
E
-
N
-
P
-
V
T
F
D
N
M
A
V
A
I
E
A
Y
E
A
T
L
I
T
P
E
A
P
F
D
K
Y
L
R
G
D
T
S
A
L
N
E
S
E
K
E
G
L
A
L
F
M
D
R
G
C
T
A
C
H
S
G
V
N
L
G
G
Q
N
-
Y
-
Y
-
P
F
G
L
-------
V
A
K
--------------------
K
G
R
F
----
S
-----
V
T
E
T
--
A
SDE
Y
--
V
F
R
A
S
P
L
R
N
I
E
L
T
A
P
Y
F
H
S
G
A
V
W
S
L
E
E
A
V
A
V
M
G
T
A
Q
L
G
T
E
L
N
N
D
E
V
K
S
I
V
A
F
L
K
T
L
T
G
N
V
P
E
V
T
Y
P
V
L
P
P
S
T
A
N
T
P
K
P
V
D
-
21
PsiBlast_CBE
89.88
46%
-56
- C5 -
3HQ6
3
?
B:
[22-343]
----------------------A--
D
E
L
Q
Q
R
A
Q
G
L
F
K
P
V
P
A
----
K
A
P
T
L
K
-------
G
N
P
A
S
P
V
----
K
------
V
E
L
G
K
M
L
Y
F
D
P
R
L
S
A
S
H
L
I
S
C
N
T
C
H
N
V
G
L
G
G
G
D
L
Q
A
T
S
T
G
H
G
W
Q
K
G
P
R
--
N
A
P
T
V
L
N
S
V
F
N
T
A
Q
F
W
D
G
R
A
K
D
L
A
E
Q
A
K
G
P
V
Q
A
S
V
E
M
N
N
T
P
D
Q
V
V
K
T
L
N
S
I
P
D
Y
V
A
L
F
K
K
A
F
P
G
E
K
-
D
-
P
-
V
T
F
D
N
M
A
K
A
I
E
V
F
E
A
T
L
I
T
P
D
S
P
F
D
Q
Y
L
K
G
K
K
K
A
L
D
G
K
Q
T
A
G
L
K
L
F
L
D
K
G
C
V
A
C
H
G
G
L
N
L
G
G
-
T
-
G
-
Y
F
P
F
G
V
-------
V
E
K
---------------------
G
R
F
----
A
-----
V
T
N
T
--
A
KDE
Y
--
V
F
R
A
P
S
L
R
N
V
A
I
T
Y
P
Y
F
H
S
G
V
V
W
S
L
K
E
A
V
A
V
M
G
S
A
Q
F
G
I
K
L
S
D
D
E
S
E
A
I
A
A
F
L
G
S
L
T
G
K
Q
P
K
V
V
Y
P
I
M
P
A
S
T
D
A
T
P
R
P
R
L
-
28
PsiBlast_CBE
89.87
44%
-53
- C5 -
3O5C
3
?
D:
[11-312]
------------------------------------------------------------
E
P
I
E
V
I
T
P
A
K
ITEPEK
V
E
L
G
K
M
L
F
F
E
P
R
L
S
K
S
G
F
I
S
C
N
S
C
H
N
L
S
T
G
G
V
D
A
L
P
T
S
I
G
H
H
W
Q
E
G
P
--
I
N
S
P
T
V
L
N
A
D
F
M
L
A
Q
F
W
D
G
R
A
S
N
L
K
E
Q
A
A
G
P
I
A
N
P
K
E
M
G
F
T
H
E
L
A
T
E
T
I
A
S
M
P
A
Y
R
A
R
F
A
K
V
Y
-
G
D
E
---
K
-
V
D
I
D
R
L
T
D
A
I
A
A
F
E
K
T
L
V
T
P
N
S
P
F
D
Q
Y
L
L
G
K
Q
D
A
I
S
G
D
A
K
A
G
Y
Q
L
F
K
D
K
G
C
V
S
C
H
N
G
P
A
V
G
G
-
T
-
M
F
M
-
K
M
G
L
-------
I
-
K
P
-----
F
H
------
T
N
N
---
P
A
E
G
----
R
-----
K
G
V
T
--
G
KDADKF
V
F
K
V
P
T
L
R
N
I
E
L
T
Y
P
Y
F
H
D
G
S
V
W
T
L
E
E
A
V
N
T
M
A
D
I
Q
L
G
Q
K
L
T
E
K
E
T
K
E
M
V
A
F
L
N
S
L
T
G
E
Q
P
Q
I
S
L
P
I
L
P
P
S
N
K
E
T
P
R
P
V
P
-
54
HHSearch
89.86
45%
-53
- C5 -
3O5C
3
?
A:
[15-314]
----------------------------------------------------------
V
I
T
P
A
K
I
T
E
P
E
K
------
V
E
L
G
K
M
L
F
F
E
P
R
L
S
K
S
G
F
I
S
C
N
S
C
H
N
L
S
T
G
G
V
D
A
L
P
T
S
I
G
H
H
W
Q
E
G
P
--
I
N
S
P
T
V
L
N
A
D
F
M
L
A
Q
F
W
D
G
R
A
S
N
L
K
E
Q
A
A
G
P
I
A
N
P
K
E
M
G
F
T
H
E
L
A
T
E
T
I
A
S
M
P
A
Y
R
A
R
F
A
K
V
Y
-
G
D
E
-
K
---
V
D
I
D
R
L
T
D
A
I
A
A
F
E
K
T
L
V
T
P
N
S
P
F
D
Q
Y
L
L
G
K
Q
D
A
I
S
G
D
A
K
A
G
Y
Q
L
F
K
D
K
G
C
V
S
C
H
N
G
P
A
V
G
G
-
T
M
F
-
M
-
K
M
G
L
-------
I
-
K
P
-----
F
H
TN----
N
P
A
---
E
G
R
K
GVTG
K
-----
D
A
D
K
--
F
------
V
F
K
V
P
T
L
R
N
I
E
L
T
Y
P
Y
F
H
D
G
S
V
W
T
L
E
E
A
V
N
T
M
A
D
I
Q
L
G
Q
K
L
T
E
K
E
T
K
E
M
V
A
F
L
N
S
L
T
G
E
Q
P
Q
I
S
L
P
I
L
P
P
S
N
K
E
T
P
R
P
V
P
-
49
HHSearch
89.80
47%
-60
- C5 -
1NML
6
?
A:
[22-322]
-------------------------------------------------------------
D
G
N
E
L
T
Q
A
K
------
V
E
L
G
K
M
E
F
F
E
P
R
L
S
S
S
H
L
I
S
C
N
T
C
H
N
V
G
L
G
G
D
D
E
L
P
T
S
I
G
H
G
W
Q
K
G
P
--
R
N
S
P
T
V
F
N
A
V
F
N
A
A
Q
F
W
D
G
R
A
A
D
L
A
E
Q
A
K
G
P
V
Q
A
G
V
E
M
S
S
T
P
D
R
V
V
A
T
L
K
S
M
P
E
Y
I
E
R
F
E
D
A
F
-
P
G
Q
E
N
-
P
-
V
T
F
D
N
M
A
V
A
I
E
A
Y
E
A
T
L
I
T
P
E
A
P
F
D
K
Y
L
R
G
D
T
S
A
L
N
E
S
E
K
E
G
L
A
L
F
M
D
R
G
C
T
A
C
H
S
G
V
N
L
G
G
-
Q
N
Y
-
Y
-
P
F
G
L
-------
V
-
A
K
-------------------
K
G
R
F
S
V
T
E
T
-----
A
S
D
E
--
Y
------
V
F
R
A
S
P
L
R
N
I
E
L
T
A
P
Y
F
H
S
G
A
V
W
S
L
E
E
A
V
A
V
M
G
T
A
Q
L
G
T
E
L
N
N
D
E
V
K
S
I
V
A
F
L
K
T
L
T
G
N
V
P
E
V
T
Y
P
V
L
P
P
S
T
A
N
T
P
K
P
V
D
-
13
PsiBlast_PDB
89.80
44%
-52
- C5 -
3O5C
3
?
A:
[11-312]
------------------------------------------------------------
E
P
I
E
V
I
T
P
A
K
ITE
P
E
K
V
E
L
G
K
M
L
F
F
E
P
R
L
S
K
S
G
F
I
S
C
N
S
C
H
N
L
S
T
G
G
V
D
A
L
P
T
S
I
G
H
H
W
Q
E
G
P
--
I
N
S
P
T
V
L
N
A
D
F
M
L
A
Q
F
W
D
G
R
A
S
N
L
K
E
Q
A
A
G
P
I
A
N
P
K
E
M
G
F
T
H
E
L
A
T
E
T
I
A
S
M
P
A
Y
R
A
R
F
A
K
V
Y
-
G
D
E
---
K
-
V
D
I
D
R
L
T
D
A
I
A
A
F
E
K
T
L
V
T
P
N
S
P
F
D
Q
Y
L
L
G
K
Q
D
A
I
S
G
D
A
K
A
G
Y
Q
L
F
K
D
K
G
C
V
S
C
H
N
G
P
A
V
G
G
-
T
-
M
F
M
-
K
M
G
L
-------
I
-
K
P
-----
F
H
------
T
N
N
---
P
A
E
G
----
R
-----
K
G
V
T
--
G
KDADKF
V
F
K
V
P
T
L
R
N
I
E
L
T
Y
P
Y
F
H
D
G
S
V
W
T
L
E
E
A
V
N
T
M
A
D
I
Q
L
G
Q
K
L
T
E
K
E
T
K
E
M
V
A
F
L
N
S
L
T
G
E
Q
P
Q
I
S
L
P
I
L
P
P
S
N
K
E
T
P
R
P
V
P
-
7
PsiBlast_PDB
89.78
46%
-62
- C5 -
1NML
6
?
A:
[26-321]
-----------------------------------------------------------------
L
T
Q
A
K
------
V
E
L
G
K
M
E
F
F
E
P
R
L
S
S
S
H
L
I
S
C
N
T
C
H
N
V
G
L
G
G
D
D
E
L
P
T
S
I
G
H
G
W
Q
K
G
P
R
--
N
S
P
T
V
F
N
A
V
F
N
A
A
Q
F
W
D
G
R
A
A
D
L
A
E
Q
A
K
G
P
V
Q
A
G
V
E
M
S
S
T
P
D
R
V
V
A
T
L
K
S
M
P
E
Y
I
E
R
F
E
D
A
F
P
G
Q
E
-
N
-
P
-
V
T
F
D
N
M
A
V
A
I
E
A
Y
E
A
T
L
I
T
P
E
A
P
F
D
K
Y
L
R
G
D
T
S
A
L
N
E
S
E
K
E
G
L
A
L
F
M
D
R
G
C
T
A
C
H
S
G
V
N
L
G
G
Q
N
-
Y
-
Y
-
P
F
G
L
-------
V
A
K
--------------------
K
G
R
F
----
S
-----
V
T
E
T
--
A
SDE
Y
--
V
F
R
A
S
P
L
R
N
I
E
L
T
A
P
Y
F
H
S
G
A
V
W
S
L
E
E
A
V
A
V
M
G
T
A
Q
L
G
T
E
L
N
N
D
E
V
K
S
I
V
A
F
L
K
T
L
T
G
N
V
P
E
V
T
Y
P
V
L
P
P
S
T
A
N
T
P
K
P
V
D
-
9
PsiBlast_PDB
89.74
46%
-61
- C5 -
1RZ6
6
?
A:
[26-321]
-----------------------------------------------------------------
L
T
Q
A
K
------
V
E
L
G
K
M
E
F
F
E
P
R
L
S
S
S
H
L
I
S
C
N
T
C
H
N
V
G
L
G
G
D
D
E
L
P
T
S
I
G
H
G
W
Q
K
G
P
R
--
N
S
P
T
V
F
N
A
V
F
N
A
A
Q
F
W
D
G
R
A
A
D
L
A
E
Q
A
K
G
P
V
Q
A
G
V
E
M
S
S
T
P
D
R
V
V
A
T
L
K
S
M
P
E
Y
I
E
R
F
E
D
A
F
P
G
Q
E
-
N
-
P
-
V
T
F
D
N
M
A
V
A
I
E
A
Y
E
A
T
L
I
T
P
E
A
P
F
D
K
Y
L
R
G
D
T
S
A
L
N
E
S
E
K
E
G
L
A
L
F
M
D
R
G
C
T
A
C
H
S
G
V
N
L
G
G
Q
N
-
Y
-
Y
-
P
F
G
L
-------
V
A
K
--------------------
K
G
R
F
----
S
-----
V
T
E
T
--
A
SDE
Y
--
V
F
R
A
S
P
L
R
N
I
E
L
T
A
P
Y
F
H
S
G
A
V
W
S
L
E
E
A
V
A
V
M
G
T
A
Q
L
G
T
E
L
N
N
D
E
V
K
S
I
V
A
F
L
K
T
L
T
G
N
V
P
E
V
T
Y
P
V
L
P
P
S
T
A
N
T
P
K
P
V
--
29
PsiBlast_CBE
89.36
44%
-53
- C5 -
3O5C
4
?
C:
[11-312]
------------------------------------------------------------
E
P
I
E
V
I
T
P
A
-ITEPEK
V
E
L
G
K
M
L
F
F
E
P
R
L
S
K
S
G
F
I
S
C
N
S
C
H
N
L
S
T
G
G
V
D
A
L
P
T
S
I
G
H
H
W
Q
E
G
P
--
I
N
S
P
T
V
L
N
A
D
F
M
L
A
Q
F
W
D
G
R
A
S
N
L
K
E
Q
A
A
G
P
I
A
N
P
K
E
M
G
F
T
H
E
L
A
T
E
T
I
A
S
M
P
A
Y
R
A
R
F
A
K
V
Y
-
G
D
E
---
K
-
V
D
I
D
R
L
T
D
A
I
A
A
F
E
K
T
L
V
T
P
N
S
P
F
D
Q
Y
L
L
G
K
Q
D
A
I
S
G
D
A
K
A
G
Y
Q
L
F
K
D
K
G
C
V
S
C
H
N
G
P
A
V
G
G
-
T
-
M
F
M
-
K
M
G
L
-------
I
-
K
P
-----
F
H
------
T
N
N
---
P
A
E
G
----
R
-----
K
G
V
T
--
G
KDADKF
V
F
K
V
P
T
L
R
N
I
E
L
T
Y
P
Y
F
H
D
G
S
V
W
T
L
E
E
A
V
N
T
M
A
D
I
Q
L
G
Q
K
L
T
E
K
E
T
K
E
M
V
A
F
L
N
S
L
T
G
E
Q
P
Q
I
S
L
P
I
L
P
P
S
N
K
E
T
P
R
P
V
P
-
3
PsiBlast_PDB
89.17
49%
-71
- C5 -
4AAO
8
?
A:
[44-338]
------------------------------------------------------------------
S
P
S
R
------
V
E
L
G
R
M
L
F
F
D
P
R
L
S
A
S
H
L
I
S
C
N
T
C
H
N
V
G
L
G
G
T
D
I
L
E
T
S
-------
G
P
R
--
N
S
P
T
V
L
N
A
V
Y
N
I
A
Q
F
W
D
G
R
A
E
D
L
A
A
-
A
K
G
P
V
Q
A
S
V
E
M
N
N
K
P
E
N
L
V
A
T
L
K
S
I
P
G
Y
P
P
L
F
R
K
A
F
P
G
Q
G
-
D
-
P
-
V
T
F
D
N
V
A
K
A
I
E
V
F
E
A
T
L
V
T
P
D
A
P
F
D
K
Y
L
K
G
N
R
K
A
I
S
S
T
A
E
Q
G
L
A
L
F
L
D
K
G
C
A
A
C
H
S
G
V
N
M
G
G
-
T
-
G
-
Y
F
P
F
G
V
R
E
D------------------------------
Y
----
K
VTSTA
A
D
K
Y
---------
V
F
R
S
P
S
L
R
N
V
A
I
T
M
P
Y
F
H
S
G
K
V
W
K
L
K
D
A
V
K
I
M
G
S
A
Q
L
G
I
S
I
T
D
A
D
A
D
K
I
V
T
F
L
N
T
L
T
G
A
Q
P
K
V
M
H
P
V
L
P
P
N
S
D
D
T
P
R
P
V
S
-
23
PsiBlast_CBE
88.99
49%
-69
- C5 -
4AAO
8
?
B:
[44-338]
------------------------------------------------------------------
S
P
S
R
------
V
E
L
G
R
M
L
F
F
D
P
R
L
S
A
S
H
L
I
S
C
N
T
C
H
N
V
G
L
G
G
T
D
I
L
E
T
S
-------
G
P
R
--
N
S
P
T
V
L
N
A
V
Y
N
I
A
Q
F
W
D
G
R
A
E
D
L
A
A
Q
A
K
G
P
V
Q
A
S
V
E
M
N
N
K
P
E
N
L
V
A
T
L
K
S
I
P
G
Y
P
P
L
F
R
K
A
F
P
G
Q
G
-
D
-
P
-
V
T
F
D
N
V
A
K
A
I
E
V
F
E
A
T
L
V
T
P
D
A
P
F
D
K
Y
L
K
G
N
R
K
A
I
S
S
T
A
E
Q
G
L
A
L
F
L
D
K
G
C
A
A
C
H
S
G
V
N
M
G
G
-
T
-
G
-
Y
F
P
F
G
V
R
ED----------------------------
G
R
Y
----
K
V
T
S
T
A
A
D
K
Y
---------
V
F
R
S
P
S
L
R
N
V
A
I
T
M
P
Y
F
H
S
G
K
V
W
K
L
K
D
A
V
K
I
M
G
S
A
Q
L
G
I
S
I
T
D
A
D
A
D
K
I
V
T
F
L
N
T
L
T
G
A
Q
P
K
V
M
H
P
V
L
P
P
N
S
D
D
T
P
R
P
V
S
-
30
PsiBlast_CBE
88.91
44%
-52
- C5 -
3O5C
3
?
B:
[11-312]
------------------------------------------------------------
E
P
I
E
V
I
T
P
A
K
ITEPEK
V
E
L
G
K
M
L
F
F
E
P
R
L
S
K
S
G
F
I
S
C
N
S
C
H
N
L
S
T
G
G
V
D
A
L
P
T
S
I
G
H
H
W
Q
E
G
P
--
I
N
S
P
T
V
L
N
A
D
F
M
L
A
Q
F
W
D
G
R
A
S
N
L
K
E
Q
A
A
G
P
I
A
N
P
K
E
M
G
F
T
H
E
L
A
T
E
T
I
A
S
M
P
A
Y
R
A
R
F
A
K
V
Y
-
G
D
E
---
K
-
V
D
I
D
R
L
T
D
A
I
A
A
F
E
K
T
L
V
T
P
N
S
P
F
D
Q
Y
L
L
G
K
Q
D
A
I
S
G
D
A
K
A
G
Y
Q
L
F
K
D
K
G
C
V
S
C
H
N
G
P
A
V
G
G
-
T
-
M
F
M
-
K
M
G
L
-------
I
-
K
P
-----
F
H
------
T
N
N
---
P
A
E
G
----
R
-----
K
G
V
T
--
G
KDADKF
V
F
K
V
P
T
L
R
N
I
E
L
T
Y
P
Y
F
H
D
G
S
V
W
T
L
E
E
A
V
N
T
M
A
D
I
Q
L
G
Q
K
L
T
E
K
E
T
K
E
M
V
A
F
L
N
S
L
T
G
E
Q
P
Q
I
S
L
P
I
L
P
P
S
N
K
E
T
P
R
P
V
P
-
5
PsiBlast_PDB
88.83
49%
-52
- C5 -
4AAM
5
?
A:
[44-338]
------------------------------------------------------------------
S
P
S
R
------
V
E
L
G
R
M
L
F
F
D
P
R
L
S
A
S
H
L
I
S
C
N
T
C
H
N
V
G
L
G
G
T
D
I
L
E
T
S
I
G
H
G
W
Q
K
G
P
R
--
N
S
P
T
V
L
N
A
V
Y
N
I
A
Q
F
W
D
G
R
A
E
D
L
A
A
Q
A
K
G
P
V
Q
A
S
V
E
M
N
N
K
P
E
N
L
V
A
T
L
K
S
I
P
G
Y
P
P
L
F
R
K
A
F
P
G
Q
G
-
D
-
P
-
V
T
F
D
N
V
A
K
A
I
E
V
F
E
A
T
L
V
T
P
D
A
P
F
D
K
Y
L
K
G
N
R
K
A
I
S
S
T
A
E
Q
G
L
A
L
F
L
D
K
G
C
A
A
C
H
S
G
V
N
M
G
G
-
T
-
G
-
Y
F
P
F
G
V
REDPGPV
V
-
R
P
-----
V
D
--------
D
---
T
G
R
Y
----
K
VTSTA
A
D
K
Y
---------
V
F
R
S
P
S
L
R
N
V
A
I
T
M
P
Y
F
H
S
G
K
V
W
K
L
K
D
A
V
K
I
M
G
S
A
Q
L
G
I
S
I
T
D
A
D
A
D
K
I
V
T
F
L
N
T
L
T
G
A
Q
P
K
V
M
H
P
V
L
P
P
N
S
D
D
T
P
R
P
V
S
-
24
PsiBlast_CBE
88.61
49%
-58
- C5 -
4AAL
9
?
B:
[44-338]
------------------------------------------------------------------
S
P
S
R
------
V
E
L
G
R
M
L
F
F
D
P
R
L
S
A
S
H
L
I
S
C
N
T
C
H
N
V
G
L
G
G
T
D
I
L
E
T
S
I
G
H
G
W
Q
K
G
P
R
--
N
S
P
T
V
L
N
A
V
Y
N
I
A
Q
F
W
D
G
R
A
E
D
L
A
A
Q
A
K
G
P
V
Q
A
S
V
E
M
N
N
K
P
E
N
L
V
A
T
L
K
S
I
P
G
Y
P
P
L
F
R
K
A
F
P
G
Q
G
-
D
-
P
-
V
T
F
D
N
V
A
K
A
I
E
V
F
E
A
T
L
V
T
P
D
A
P
F
D
K
Y
L
K
G
N
R
K
A
I
S
S
T
A
E
Q
G
L
A
L
F
L
D
K
G
C
A
A
C
H
S
G
V
N
M
G
G
-
T
-
G
-
Y
F
P
F
G
V
R
E
DPG-----------
V
D
--------
D
---
T
G
R
Y
----
K
V
T
S
T
A
A
D
K
Y
---------
V
F
R
S
P
S
L
R
N
V
A
I
T
M
P
Y
F
H
S
G
K
V
W
K
L
K
D
A
V
K
I
M
G
S
A
Q
L
G
I
S
I
T
D
A
D
A
D
K
I
V
T
F
L
N
T
L
T
G
A
Q
P
K
V
M
H
P
V
L
P
P
N
S
D
D
T
P
R
P
V
S
-
4
PsiBlast_PDB
87.89
49%
-58
- C5 -
4AAL
15
?
A:
[44-338]
------------------------------------------------------------------
S
P
S
R
------
V
E
L
G
R
M
L
F
F
D
P
R
L
S
A
S
H
L
I
S
C
N
T
C
H
N
V
G
L
G
G
T
D
I
L
E
T
S
I
G
H
G
W
Q
K
G
P
R
--
N
S
P
T
V
L
N
A
V
Y
N
I
A
Q
F
W
D
G
R
A
E
D
L
A
A
Q
A
K
G
P
V
Q
A
S
V
E
M
N
N
K
P
E
N
L
V
A
T
L
K
S
I
P
G
Y
P
P
L
F
R
K
A
F
P
G
Q
G
-
D
-
P
-
V
T
F
D
N
V
A
K
A
I
E
V
F
E
A
T
L
V
T
P
D
A
P
F
D
K
Y
L
K
G
N
R
K
A
I
S
S
T
A
E
Q
G
L
A
L
F
L
D
K
G
C
A
A
C
H
S
G
V
N
M
G
G
-
T
-
G
-
Y
F
P
F
G
V
R
EDPG-----
P
-----
V
D
--------
D
---
T
G
R
Y
----
K
VTSTA
A
D
K
Y
---------
V
F
R
S
P
S
L
R
N
V
A
I
T
M
P
Y
F
H
S
G
K
V
W
K
L
K
D
A
V
K
I
M
G
S
A
Q
L
G
I
S
I
T
D
A
D
A
D
K
I
V
T
F
L
N
T
L
T
G
A
Q
P
K
V
M
H
P
V
L
P
P
N
S
D
D
T
P
R
P
V
S
-
1
PsiBlast_PDB
87.78
46%
-58
- C5 -
3HQ7
3
?
A:
[20-343]
----------------------FAA
D
E
L
Q
Q
R
A
Q
G
L
F
K
P
V
P
A
----
K
A
P
T
L
K
-------
G
N
P
A
S
P
V
----
K
------
V
E
L
G
K
M
L
Y
F
D
P
R
L
S
A
S
H
L
I
S
C
N
T
C
H
N
V
G
L
G
G
G
D
L
Q
A
T
S
T
G
H
K
W
Q
Q
G
P
--
I
N
A
P
T
V
L
N
S
V
F
N
T
A
-------------
A
K
G
P
V
Q
A
S
V
E
M
N
N
T
P
D
Q
V
V
K
T
L
N
S
I
P
D
Y
V
A
L
F
K
K
A
F
P
G
E
K
-
D
-
P
-
V
T
F
D
N
M
A
K
A
I
E
V
F
E
A
T
L
I
T
P
D
S
P
F
D
Q
Y
L
K
G
K
K
K
A
L
D
G
K
Q
T
A
G
L
K
L
F
L
D
K
G
C
V
A
C
H
G
G
L
N
L
G
G
-
T
-
G
-
Y
F
P
F
G
V
-------
V
E
K
P
-------------------
K
G
R
F
----
A
-----
V
T
N
T
--
A
KDE
Y
--
V
F
R
A
P
S
L
R
N
V
A
I
T
Y
P
Y
F
H
S
G
V
V
W
S
L
K
E
A
V
A
V
M
G
S
A
Q
F
G
I
K
L
S
D
D
E
S
E
A
I
A
A
F
L
G
S
L
T
G
K
Q
P
K
V
V
Y
P
I
M
P
A
S
T
D
A
T
P
R
P
R
L
-
25
PsiBlast_CBE
87.37
45%
-58
- C5 -
3HQ8
4
?
B:
[22-343]
----------------------A--
D
E
L
Q
Q
R
A
Q
G
L
F
K
P
V
P
A
----
K
A
P
T
L
K
-----------
G
N
P
A
S
P
V
K
------
V
E
L
G
K
M
L
Y
F
D
P
R
L
S
A
S
H
L
I
S
C
N
T
C
H
N
V
G
L
G
G
G
D
L
Q
A
T
S
T
G
H
G
W
Q
K
G
P
R
--
N
A
P
T
V
L
N
S
V
F
N
T
A
Q
F
W
D
G
R
A
K
D
L
A
E
Q
A
K
G
P
V
Q
A
P
K
E
M
N
N
T
P
D
Q
V
V
K
T
L
N
S
I
P
D
Y
V
A
L
F
K
K
A
F
P
G
E
K
-
D
-
P
-
V
T
F
D
N
M
A
K
A
I
E
V
F
E
A
T
L
I
T
P
D
S
P
F
D
Q
Y
L
K
G
K
K
K
A
L
D
G
K
Q
T
A
G
L
K
L
F
L
D
K
G
C
V
A
C
H
G
G
L
N
L
G
G
-
T
-
G
-
Y
F
P
F
G
V
-------
V
E
K
---------------------
G
R
F
----
A
-----
V
T
N
T
--
A
KDE
Y
--
V
F
R
A
P
S
L
R
N
V
A
I
T
Y
P
Y
F
H
S
G
V
V
W
S
L
K
E
A
V
A
V
M
G
S
A
Q
F
G
I
K
L
S
D
D
E
S
E
A
I
A
A
F
L
G
S
L
T
G
K
Q
P
K
V
V
Y
P
I
M
P
A
S
T
D
A
T
P
R
P
R
L
-
53
HHSearch
86.75
43%
-52
- C5 -
1IQC
5
CCPR_NITEU
A:
[9-304]
------------------------------------------------------------
K
A
V
T
P
E
N
A
D
M
------
A
E
L
G
K
M
L
F
F
D
P
R
L
S
K
S
G
F
I
S
C
N
S
C
H
N
L
S
M
G
G
T
D
N
I
T
T
S
I
G
H
K
W
Q
Q
G
P
--
I
N
A
P
T
V
L
N
S
S
M
N
L
A
Q
F
W
D
G
R
A
K
D
L
K
E
Q
A
A
G
P
I
A
N
P
K
E
M
A
S
T
H
E
I
A
E
K
V
V
A
S
M
P
Q
Y
R
E
R
F
K
K
V
F
-
G
S
D
---
E
-
V
T
I
D
R
I
T
T
A
I
A
Q
F
E
E
T
L
V
T
P
G
S
K
F
D
K
W
L
E
G
D
K
N
A
L
N
Q
D
E
L
E
G
Y
N
L
F
K
G
S
G
C
V
Q
C
H
N
G
P
A
V
G
G
-
S
S
Y
-
Q
-
K
M
G
V
-------
F
-
K
P
-----
Y
E
TK----
N
P
A
---
A
G
R
M
DVTG
N
-----
E
A
D
R
--
N
------
V
F
K
V
P
T
L
R
N
I
E
L
T
Y
P
Y
F
H
D
G
G
A
A
T
L
E
Q
A
V
E
T
M
G
R
I
Q
L
N
R
E
F
N
K
D
E
V
S
K
I
V
A
F
L
K
T
L
T
G
D
Q
P
D
F
K
L
P
I
L
P
P
S
N
N
D
T
P
R
S
Q
P
-