@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_1373: (2015-12-23 )
MIDRKLLLQDFDKVALSLKKRNHAMDDELERLREAIAHYKKQLIELEGLQAFQNKVSKEFGIKMAQKMDTSDLKKELENNKIKLNELSKSVGEAEQEMDLKLSIIPNLVDEKTPLGASEEDNIEIKKILTPRNFTFKPKEHFELAQQNGWIDFESGVKLAKSRFSVIRGFGAKIYRALIHLMLDFNEKNGFEIIYTPALVNEKMLFGTGQLPKFKEDVFKIENENLYLIPTAEVTLTNLYNDTIISVENLPIKMTAHTPCFRSEAGSAGKDTRGMIRQHQFDKVELVAITHPKESDAMQEHMLESASEILKALELPHRFVQLCSGDLGFSASNTIDIEVWLPGQNCYREISSVSNTRDFQARRAKIRFKENQKNQLVHTLNGSSLAVGRTMVALMENHQQADGSIHIPKALEKYL
Atome Classification :
(26 SA)
----------------........----.----10........20.-...-....30..------......40..---......50........60......--------..70-----------------------.........------------80........90--....-----------.....100..----.....110.......-120.......130.--------------------..--------------------....-140----------.........150.....-..160.......170.......180.......190.......200.......210.......220----------..--......230.......240...--.--...250.......260.......270.......280.......290--.--....--..300.......310.......320.......330.......340.......350.......360.......-370.--.--..----.---....380.......390.......400.......410...----------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----------------MI
D
R
K
L
L
L
----
Q
----
D
F
D
K
V
A
L
S
L
K
KRN-HA
M
-
D
D
E
L
E
R
L
R
------
E
A
I
A
H
Y
K
K
Q
L
---
I
E
L
E
G
L
Q
A
F
Q
N
K
V
S
K
E
F
G
I
K
M
A
Q
K--------M
D
T
------------------------
S
D
L
K
K
E
L
EN------------N
K
I
K
L
N
E
L
S
K
S
---VG
E
A
-----------
E
Q
EM
D
L
K
L
S
I----I
P
N
LVDEKTPLGASE-ED
N
I
E
I
K
K
ILTPRN--------------------FT--------------------FK
P
K
-
E
------------
H
F
E
L
A
Q
QNG
W
I
D
F
E
SG
V
-
K
L
A
K
S
R
F
S
V
I
R
G
F
G
A
K
I
Y
R
A
L
I
H
L
M
L
DFNEKNG
F
E
I
I
YTPALVNE
K
M
L
FGTGQL
P
K
F
K
E
D
V
F
K
I-----------EN--E
N
L
Y
L
I
PTA
E
V
T
L
T
NLYN
D
T
I
I
--
S
--VEN
L
P
I
K
M
TAHTPCFRSEAGSAGK
D
T
R
G
M
I
R
QHQFD
K
V
E
L
V
A
I
THP--K--
E
S
D
A
--
M
Q
E
H
M
L
E
S
A
S
E
I
L
K
A
L
EL
P
H
R
F
V
Q
LCSGDLGFSAS
N
T
I
D
I
E
V
W
LP
G
Q
N
C
Y
R
E
I
S
S
VSNT
R
D
F
Q
A
R
R
A
K
I
R
F
K-E--N--Q--KN----
Q
---
L
V
H
TLNGSS
L
A
V
G
R
T
M
V
A
L
M
E
N
HQQADGSIH
I
P
K
A
L
E
K
YL----------------------
32
HHSearch
88.09
49%
-69
- C1 -
2DQ3
1
SYS_AQUAE
A:
[1-417]
----------------
M
I
D
I
N
L
I
R
----
E
----
K
P
D
Y
V
K
E
R
L
A
T
R
D
-
K
E
L
-
V
S
L
V
D
K
V
L
------
E
L
D
K
R
R
R
E
I
I
---
K
R
L
E
A
L
R
S
E
R
N
K
L
S
K
E
I
G
K
L
K
R
E
G
--------
K
D
T
------------------------
T
E
I
Q
N
R
V
K
E
------------
L
K
E
E
I
D
R
L
E
E
E
---
L
R
K
V
-----------
E
E
E
L
K
N
T
L
L
W
----
I
P
N
L
P
H
P
S
V
P
V
G
E
D
E
-
K
D
N
V
E
V
R
R
W
G
E
P
R
K
--------------------
F
D
--------------------
F
E
P
K
-
P
------------
H
W
E
I
G
E
R
L
G
I
L
D
F
K
R
G
A
-
K
L
S
G
S
R
F
T
V
I
A
G
W
G
A
R
L
E
R
A
L
I
N
F
M
L
D
L
H
T
K
K
G
Y
K
E
I
C
P
P
H
L
V
K
P
E
I
L
I
G
T
G
Q
L
P
K
F
E
E
D
L
Y
K
C
-----------
E
R
--
D
N
L
Y
L
I
P
T
A
E
V
P
L
T
N
L
Y
R
E
E
I
L
--
K
--
E
E
N
L
P
I
Y
L
T
A
Y
T
P
C
Y
R
R
E
A
G
A
Y
G
K
D
I
R
G
I
I
R
Q
H
Q
F
D
K
V
E
L
V
K
I
V
H
P
--
D
--
T
S
Y
D
--
E
L
E
K
L
V
K
D
A
E
E
V
L
Q
L
L
G
L
P
Y
R
V
V
E
L
C
T
G
D
L
G
F
S
A
A
K
T
Y
D
I
E
V
W
F
P
S
Q
N
K
Y
R
E
I
S
S
C
S
N
C
E
D
F
Q
A
R
R
M
N
T
R
F
K
-
D
--
S
KT
G
--
K
N
----
R
---
F
V
H
T
L
N
G
S
G
L
A
V
G
R
T
L
A
A
I
L
E
N
Y
Q
Q
E
D
G
S
V
V
V
P
E
V
L
R
D
Y
V
----------------------
1
PsiBlast_PDB
87.69
48%
-68
- C1 -
2DQ3
1
SYS_AQUAE
A:
[2-417]
-----------------
I
D
I
N
L
I
R
----
E
----
K
P
D
Y
V
K
E
R
L
A
T
R
D
-
K
E
L
-
V
S
L
V
D
K
V
L
------
E
L
D
K
R
R
R
E
I
I
---
K
R
L
E
A
L
R
S
E
R
N
K
L
S
K
E
I
G
K
L
K
R
E
G
--------
K
D
T
------------------------
T
E
I
Q
N
R
V
K
E
------------
L
K
E
E
I
D
R
L
E
E
E
---
L
R
K
V
-----------
E
E
E
L
K
N
T
L
L
W
----
I
P
N
L
P
H
P
S
V
P
V
G
E
D
E
-
K
D
N
V
E
V
R
R
W
G
E
P
R
K
--------------------
F
D
--------------------
F
E
P
K
-
P
------------
H
W
E
I
G
E
R
L
G
I
L
D
F
K
R
G
A
-
K
L
S
G
S
R
F
T
V
I
A
G
W
G
A
R
L
E
R
A
L
I
N
F
M
L
D
L
H
T
K
K
G
Y
K
E
I
C
P
P
H
L
V
K
P
E
I
L
I
G
T
G
Q
L
P
K
F
E
E
D
L
Y
K
C
-----------
E
R
--
D
N
L
Y
L
I
P
T
A
E
V
P
L
T
N
L
Y
R
E
E
I
L
--
K
--
E
E
N
L
P
I
Y
L
T
A
Y
T
P
C
Y
R
R
E
A
G
A
Y
G
K
D
I
R
G
I
I
R
Q
H
Q
F
D
K
V
E
L
V
K
I
V
H
P
--
D
--
T
S
Y
D
--
E
L
E
K
L
V
K
D
A
E
E
V
L
Q
L
L
G
L
P
Y
R
V
V
E
L
C
T
G
D
L
G
F
S
A
A
K
T
Y
D
I
E
V
W
F
P
S
Q
N
K
Y
R
E
I
S
S
C
S
N
C
E
D
F
Q
A
R
R
M
N
T
R
F
K
-
D
--
S
--
K
TG
K
N
----
R
---
F
V
H
T
L
N
G
S
G
L
A
V
G
R
T
L
A
A
I
L
E
N
Y
Q
Q
E
D
G
S
V
V
V
P
E
V
L
R
D
Y
V
----------------------
34
HHSearch
83.67
36%
-63
- C1 -
2DQ0
5
SYS_PYRHO
A:
[1-438]
----------------
M
L
D
I
K
L
I
R
----
E
----
N
P
E
L
V
K
N
D
L
I
K
R
G
-
E
L
E
K
V
K
W
V
D
E
I
L
------
K
L
D
T
E
W
R
T
K
L
---
K
E
I
N
R
L
R
H
E
R
N
K
I
A
V
E
I
G
K
R
R
K
K
G
--------
E
P
V
------------------------
D
E
L
L
A
K
S
R
E
------------
I
V
K
R
I
G
E
L
E
N
E
---
V
E
E
L
-----------
K
K
K
I
D
Y
Y
L
W
R
----
L
P
N
I
T
H
P
S
V
P
V
G
K
D
E
-
N
D
N
V
P
I
R
F
W
G
K
A
R
V
WKGH
L
E
R
F
L
E
Q
S
QGK
M
E
Y
E
I
L
E
--------------------
W
K
P
K
-
L
------------
H
V
D
L
L
E
I
L
G
G
A
D
F
A
R
A
A
-
K
V
S
G
S
R
F
Y
Y
L
L
N
E
I
V
I
L
D
L
A
L
I
R
F
A
L
D
R
L
I
E
K
G
F
T
P
V
I
P
P
Y
M
V
R
R
F
V
E
E
G
S
T
S
F
E
D
F
E
D
V
I
Y
K
V
-----------
E
D
--
E
D
L
Y
L
I
P
T
A
E
H
P
L
A
G
M
H
A
N
E
I
L
--
D
--
G
K
D
L
P
L
L
Y
V
G
V
S
P
C
F
R
K
E
A
G
T
A
G
K
D
T
K
G
I
F
R
V
H
Q
F
H
K
V
E
Q
F
V
Y
S
R
P
--
E
--
E
S
W
E
--
W
H
E
K
I
I
R
N
A
E
E
L
F
Q
E
L
E
I
P
Y
R
V
V
N
I
C
T
G
D
L
G
Y
V
A
A
K
K
Y
D
I
E
A
W
M
P
G
Q
G
K
F
R
E
V
V
S
A
S
N
C
T
D
W
Q
A
R
R
L
N
I
R
F
R
-
D
--
R
TD
E
--
K
P
----
R
---
Y
V
H
T
L
N
S
T
A
I
A
T
S
R
A
I
V
A
I
L
E
N
H
Q
E
E
D
G
T
V
R
I
P
K
V
L
W
K
Y
T
----------------------
22
PsiBlast_CBE
82.66
34%
-61
- C1 -
2DQ0
4
SYS_PYRHO
B:
[1-437]
----------------
M
L
D
I
K
L
I
R
----
E
----
N
P
E
L
V
K
N
D
L
I
K
R
G
-------
E
L
E
K
V
K
WVDEIL
K
L
D
T
E
W
R
T
K
L
---
K
E
I
N
R
L
R
H
E
R
N
K
I
A
V
E
I
G
K
R
R
K
K
G
--------
E
P
V
------------------------
D
E
L
L
A
K
S
R
E
------------
I
V
K
R
I
G
E
L
E
N
E
---
V
E
E
L
-----------
K
K
K
I
D
Y
Y
L
W
R
----
L
P
N
I
T
H
P
S
V
P
V
G
K
D
E
-
N
D
N
V
P
I
R
F
W
G
K
A
R
V
--------------------
W
K
GHLERFLEQSQGKMEYEILE
W
K
P
K
-
L
------------
H
V
D
L
L
E
I
L
G
G
A
D
F
A
R
A
A
-
K
V
S
G
S
R
F
Y
Y
L
L
N
E
I
V
I
L
D
L
A
L
I
R
F
A
L
D
R
L
I
E
K
G
F
T
P
V
I
P
P
Y
M
V
R
R
F
V
E
E
G
S
T
S
F
E
D
F
E
D
V
I
Y
K
V
-----------
E
D
--
E
D
L
Y
L
I
P
T
A
E
H
P
L
A
G
M
H
A
N
E
I
L
--
D
--
G
K
D
L
P
L
L
Y
V
G
V
S
P
C
F
R
K
E
A
G
T
A
G
K
D
T
K
G
I
F
R
V
H
Q
F
H
K
V
E
Q
F
V
Y
S
R
P
--
E
--
E
S
W
E
--
W
H
E
K
I
I
R
N
A
E
E
L
F
Q
E
L
E
I
P
Y
R
V
V
N
I
C
T
G
D
L
G
Y
V
A
A
K
K
Y
D
I
E
A
W
M
P
G
Q
G
K
F
R
E
V
V
S
A
S
N
C
T
D
W
Q
A
R
R
L
N
I
R
F
R
-
D
RT
D
--
E
--
K
P
----
R
---
Y
V
H
T
L
N
S
T
A
I
A
T
S
R
A
I
V
A
I
L
E
N
H
Q
E
E
D
G
T
V
R
I
P
K
V
L
W
K
Y
T
----------------------
21
PsiBlast_CBE
82.47
34%
-62
- C1 -
2ZR2
4
SYS_PYRHO
B:
[1-437]
----------------
M
L
D
I
K
L
I
R
----
E
----
N
P
E
L
V
K
N
D
L
I
K
R
G
-------
E
L
E
K
V
K
WVDEIL
K
L
D
T
E
W
R
T
K
L
---
K
E
I
N
R
L
R
H
E
R
N
K
I
A
V
E
I
G
K
R
R
K
K
G
--------
E
P
V
------------------------
D
E
L
L
A
K
S
R
E
------------
I
V
K
R
I
G
E
L
E
N
E
---
V
E
E
L
-----------
K
K
K
I
D
Y
Y
L
W
R
----
L
P
N
I
T
H
P
S
V
P
V
G
K
D
E
-
N
D
N
V
P
I
R
F
W
G
K
A
R
V
--------------------
W
K
GHLERFLEQSQGKMEYEILE
W
K
P
K
-
L
------------
H
V
D
L
L
E
I
L
G
G
A
D
F
A
R
A
A
-
K
V
S
G
S
R
F
Y
Y
L
L
N
E
I
V
I
L
D
L
A
L
I
R
F
A
L
D
R
L
I
E
K
G
F
T
P
V
I
P
P
Y
M
V
R
R
F
V
E
E
G
S
T
S
F
E
D
F
E
D
V
I
Y
K
V
-----------
E
D
--
E
D
L
Y
L
I
P
T
A
E
H
P
L
A
G
M
H
A
N
E
I
L
--
D
--
G
K
D
L
P
L
L
Y
V
G
V
S
P
C
F
R
K
E
A
G
T
A
G
K
D
T
K
G
I
F
R
V
H
Q
F
H
K
V
E
Q
F
V
Y
S
R
P
--
E
--
E
S
W
E
--
W
H
E
K
I
I
R
N
A
E
E
L
F
Q
E
L
E
I
P
Y
R
V
V
N
I
C
T
G
D
L
G
Y
V
A
A
K
K
Y
D
I
E
A
W
M
P
G
Q
G
K
F
R
E
V
V
S
A
S
N
C
T
D
W
Q
A
R
R
L
N
I
R
F
R
-
D
RT
D
--
E
--
K
P
----
R
---
Y
V
H
T
L
N
S
T
A
I
A
T
S
R
A
I
V
A
I
L
E
N
H
Q
E
E
D
G
T
V
R
I
P
K
V
L
W
K
Y
T
----------------------
2
PsiBlast_PDB
81.76
34%
-61
- C1 -
2DQ0
5
SYS_PYRHO
A:
[1-437]
----------------
M
L
D
I
K
L
I
R
----
E
----
N
P
E
L
V
K
N
D
L
I
K
R
G
-------
E
L
E
K
V
K
W
V
D
E
I
L
K
L
D
T
E
W
R
T
K
L
---
K
E
I
N
R
L
R
H
E
R
N
K
I
A
V
E
I
G
K
R
R
K
K
G
--------
E
P
V
------------------------
D
E
L
L
A
K
S
R
E
------------
I
V
K
R
I
G
E
L
E
N
E
---
V
E
E
L
-----------
K
K
K
I
D
Y
Y
L
W
R
----
L
P
N
I
T
H
P
S
V
P
V
G
K
D
E
-
N
D
N
V
P
I
R
F
W
G
K
A
R
V
--------------------
W
K
GH
L
E
R
F
L
E
Q
S
QGK
M
E
Y
E
I
L
E
W
K
P
K
-
L
------------
H
V
D
L
L
E
I
L
G
G
A
D
F
A
R
A
A
-
K
V
S
G
S
R
F
Y
Y
L
L
N
E
I
V
I
L
D
L
A
L
I
R
F
A
L
D
R
L
I
E
K
G
F
T
P
V
I
P
P
Y
M
V
R
R
F
V
E
E
G
S
T
S
F
E
D
F
E
D
V
I
Y
K
V
-----------
E
D
--
E
D
L
Y
L
I
P
T
A
E
H
P
L
A
G
M
H
A
N
E
I
L
--
D
--
G
K
D
L
P
L
L
Y
V
G
V
S
P
C
F
R
K
E
A
G
T
A
G
K
D
T
K
G
I
F
R
V
H
Q
F
H
K
V
E
Q
F
V
Y
S
R
P
--
E
--
E
S
W
E
--
W
H
E
K
I
I
R
N
A
E
E
L
F
Q
E
L
E
I
P
Y
R
V
V
N
I
C
T
G
D
L
G
Y
V
A
A
K
K
Y
D
I
E
A
W
M
P
G
Q
G
K
F
R
E
V
V
S
A
S
N
C
T
D
W
Q
A
R
R
L
N
I
R
F
R
-
D
RT
D
--
E
--
K
P
----
R
---
Y
V
H
T
L
N
S
T
A
I
A
T
S
R
A
I
V
A
I
L
E
N
H
Q
E
E
D
G
T
V
R
I
P
K
V
L
W
K
Y
T
----------------------
3
PsiBlast_PDB
81.70
34%
-62
- C1 -
2ZR2
5
SYS_PYRHO
A:
[1-437]
----------------
M
L
D
I
K
L
I
R
----
E
----
N
P
E
L
V
K
N
D
L
I
K
R
G
-------
E
L
E
K
V
K
W
V
D
E
I
L
K
L
D
T
E
W
R
T
K
L
---
K
E
I
N
R
L
R
H
E
R
N
K
I
A
V
E
I
G
K
R
R
K
K
G
--------
E
P
V
------------------------
D
E
L
L
A
K
S
R
E
------------
I
V
K
R
I
G
E
L
E
N
E
---
V
E
E
L
-----------
K
K
K
I
D
Y
Y
L
W
R
----
L
P
N
I
T
H
P
S
V
P
V
G
K
D
E
-
N
D
N
V
P
I
R
F
W
G
K
A
R
V
--------------------
W
K
GH
L
E
R
F
L
E
Q
S
QGK
M
E
Y
E
I
L
E
W
K
P
K
-
L
------------
H
V
D
L
L
E
I
L
G
G
A
D
F
A
R
A
A
-
K
V
S
G
S
R
F
Y
Y
L
L
N
E
I
V
I
L
D
L
A
L
I
R
F
A
L
D
R
L
I
E
K
G
F
T
P
V
I
P
P
Y
M
V
R
R
F
V
E
E
G
S
T
S
F
E
D
F
E
D
V
I
Y
K
V
-----------
E
D
--
E
D
L
Y
L
I
P
T
A
E
H
P
L
A
G
M
H
A
N
E
I
L
--
D
--
G
K
D
L
P
L
L
Y
V
G
V
S
P
C
F
R
K
E
A
G
T
A
G
K
D
T
K
G
I
F
R
V
H
Q
F
H
K
V
E
Q
F
V
Y
S
R
P
--
E
--
E
S
W
E
--
W
H
E
K
I
I
R
N
A
E
E
L
F
Q
E
L
E
I
P
Y
R
V
V
N
I
C
T
G
D
L
G
Y
V
A
A
K
K
Y
D
I
E
A
W
M
P
G
Q
G
K
F
R
E
V
V
S
A
S
N
C
T
D
W
Q
A
R
R
L
N
I
R
F
R
-
D
RT
D
--
E
--
K
P
----
R
---
Y
V
H
T
L
N
S
T
A
I
A
T
S
R
A
I
V
A
I
L
E
N
H
Q
E
E
D
G
T
V
R
I
P
K
V
L
W
K
Y
T
----------------------
33
HHSearch
81.17
34%
-64
- C1 -
1SES
1
SYS_THET2
A:
[1-412]
----------------
M
V
D
L
K
R
L
R
----
Q
----
E
P
E
V
F
H
R
A
I
R
E
K
G
-
V
A
---
L
D
L
E
A
L
L
------
A
L
D
R
E
V
Q
E
L
K
---
K
R
L
Q
E
V
Q
T
E
R
N
Q
V
A
K
R
V
P
K
A
P
P
----------
E
E
K
------------------------
E
A
L
I
A
R
G
K
A
------------
L
G
E
E
A
K
R
L
E
E
A
---
L
R
E
K
-----------
E
A
R
L
E
A
L
L
L
Q
----
V
P
L
P
P
W
P
G
A
P
V
G
G
E
E
--
A
N
R
E
I
K
R
V
G
G
P
P
E
--------------------
F
S
--------------------
F
P
P
L
-
D
------------
H
V
A
L
M
E
K
N
G
W
W
E
-
P
R
I
S
-
Q
V
S
G
S
R
S
Y
A
L
K
G
D
L
A
L
Y
E
L
A
L
L
R
F
A
M
D
F
M
A
R
R
G
F
L
P
M
T
L
P
S
Y
A
R
E
K
A
F
L
G
T
G
H
F
P
A
Y
R
D
Q
V
W
A
I
-----------
A
E
--
T
D
L
Y
L
T
G
T
A
E
V
V
L
N
A
L
H
S
G
E
I
L
--
P
--
Y
E
A
L
P
L
R
Y
A
G
Y
A
P
A
F
R
S
E
A
G
S
F
G
K
D
V
R
G
L
M
R
V
H
Q
F
H
K
V
E
Q
Y
V
L
T
E
A
S
L
E
--
A
S
D
R
--
A
F
Q
E
L
L
E
N
A
E
E
I
L
R
L
L
E
L
P
Y
R
L
V
E
V
A
T
G
D
M
G
P
G
K
W
R
Q
V
D
I
E
V
Y
L
P
S
E
G
R
Y
R
E
T
H
S
C
S
A
L
L
D
W
Q
A
R
R
A
N
L
R
Y
R
-
D
--
P
E-
G
--
R
V
----
R
---
Y
A
Y
T
L
N
N
T
A
L
A
T
P
R
I
L
A
M
L
L
E
N
H
Q
L
Q
D
G
R
V
R
V
P
Q
A
L
I
P
Y
M
----------------------
4
PsiBlast_PDB
80.80
34%
-60
- C1 -
2ZR3
-
SYS_PYRHO
A:
[1-437]
----------------
M
L
D
I
K
L
I
R
----
E
----
N
P
E
L
V
K
N
D
L
I
K
R
G
-------
E
L
E
K
V
K
W
V
D
E
I
L
K
L
D
T
E
W
R
T
K
L
---
K
E
I
N
R
L
R
H
E
R
N
K
I
A
V
E
I
G
K
R
R
K
K
G
--------
E
P
V
------------------------
D
E
L
L
A
K
S
R
E
------------
I
V
K
R
I
G
E
L
E
N
E
---
V
E
E
L
-----------
K
K
K
I
D
Y
Y
L
W
R
----
L
P
N
I
T
H
P
S
V
P
V
G
K
D
E
-
N
D
N
V
P
I
R
F
W
G
K
A
R
V
--------------------
W
K
GH
L
E
R
F
L
E
Q
S
QGK
M
E
Y
E
I
L
E
W
K
P
K
-
L
------------
H
V
D
L
L
E
I
L
G
G
A
D
F
A
R
A
A
-
K
V
S
G
S
R
F
Y
Y
L
L
N
E
I
V
I
L
D
L
A
L
I
R
F
A
L
D
R
L
I
E
K
G
F
T
P
V
I
P
P
Y
M
V
R
R
F
V
E
E
G
S
T
S
F
E
D
F
E
D
V
I
Y
K
V
-----------
E
D
--
E
D
L
Y
L
I
P
T
A
E
H
P
L
A
G
M
H
A
N
E
I
L
--
D
--
G
K
D
L
P
L
L
Y
V
G
V
S
P
C
F
R
K
E
A
G
T
A
G
K
D
T
K
G
I
F
R
V
H
Q
F
H
K
V
E
Q
F
V
Y
S
R
P
--
E
--
E
S
W
E
--
W
H
E
K
I
I
R
N
A
E
E
L
F
Q
E
L
E
I
P
Y
R
V
V
N
I
C
T
G
D
L
G
Y
V
A
A
K
K
Y
D
I
E
A
W
M
P
G
Q
G
K
F
R
E
V
V
S
A
S
N
C
T
D
W
Q
A
R
R
L
N
I
R
F
R
-
D
RT
D
--
E
--
K
P
----
R
---
Y
V
H
T
L
N
S
T
A
I
A
T
S
R
A
I
V
A
I
L
E
N
H
Q
E
E
D
G
T
V
R
I
P
K
V
L
W
K
Y
T
----------------------
35
HHSearch
78.05
31%
-64
- C1 -
3VBB
2
SYSC_HUMAN
A:
[2-460]
----------------
V
L
D
L
D
L
F
R
----
V
DKGG
D
P
A
L
I
R
E
T
Q
E
K
R
F
-
K
D
--
P
G
L
V
D
Q
L
V
------
K
A
D
S
E
W
R
R
C
R
---
F
R
A
D
N
L
N
K
L
K
N
L
C
S
K
T
I
G
E
K
M
K
K
K
--------
E
--DESVPENVLSFDDLT
A
D
A
L
A
N
L
KV
S
Q
I
K
K
V
R
L
L
------------
I
D
E
A
I
L
K
C
D
A
E
---
R
I
K
L
-----------
E
A
E
R
F
E
N
L
R
E
----
I
G
N
L
L
H
P
S
V
P
I
S
N
D
E
D
V
D
N
K
V
E
R
I
W
G
D
C
T
V
------------------------------------------
R
K
K
Y
-
S
------------
H
V
D
L
V
V
M
V
D
G
F
E
G
E
K
G
A
-
V
V
A
G
S
R
G
Y
F
L
K
G
V
L
V
F
L
E
Q
A
L
I
Q
Y
A
L
R
T
L
G
S
R
G
Y
I
P
I
Y
T
P
F
F
M
R
K
E
V
M
Q
E
V
A
Q
L
S
-
F
D
E
E
L
Y
K
V
-----------
I
---
D
E
K
Y
L
I
A
T
S
E
Q
P
I
A
A
L
H
R
D
E
W
L
--
R
--
P
E
D
L
P
I
K
Y
A
G
L
S
T
C
F
R
Q
E
V
G
S
----
T
R
G
I
F
R
V
H
Q
F
E
K
I
E
Q
F
V
Y
S
S
P
--
H
DN
K
S
W
E
--
M
F
E
E
M
I
T
T
A
E
E
F
Y
Q
S
L
G
I
P
Y
H
I
V
N
I
V
S
G
S
L
N
H
A
A
S
K
K
L
D
L
E
A
W
F
P
G
S
G
A
F
R
E
L
V
S
C
S
N
C
T
D
Y
Q
A
R
R
L
R
I
R
Y
G
-
Q
--
T
M-
D
--
K
V
----
E
---
F
V
H
M
L
N
A
T
M
C
A
T
T
R
T
I
C
A
I
L
E
N
Y
Q
T
E
K
G
-
I
T
V
P
E
K
L
K
E
F
M
----------------------
11
PsiBlast_PDB
77.50
31%
-61
- C1 -
3QO8
4
SYSC_CANAL
A:
[14-435]
---------------------------------
D
P
E
I
I
K
A
S
Q
K
K
R
G
------
D
S
V
E
L
V
D
------
E
I
I
A
E
Y
K
E
W
V
K
L
R
F
D
L
D
E
H
N
K
K
L
N
S
V
Q
K
E
I
G
K
R
F
K
-----------
D
A
------------------------
K
D
L
I
A
E
K
E
K
------------
L
S
N
E
K
K
E
I
I
E
K
---
E
A
E
A
-----------
D
K
N
L
R
S
K
I
N
Q
----
V
G
N
I
V
H
E
S
V
-
V
D
S
Q
D
-
E
E
N
N
E
L
V
R
T
W
T
P
E
N
--------------------
Y
K
---------------------
K
P
E
-
Q
IAAATGAPAKLS
H
H
E
V
L
L
R
L
D
G
Y
D
P
E
R
G
V
-
R
I
V
G
H
R
G
Y
F
L
R
N
Y
G
V
F
L
N
Q
A
L
I
N
Y
G
L
S
F
L
S
S
K
G
Y
V
P
L
Q
A
P
V
M
M
N
K
E
V
M
A
K
T
A
Q
L
S
Q
F
D
E
E
L
Y
K
V
I
D
G--------
E
D
--
E
K
-
Y
L
I
A
T
S
E
Q
P
I
S
A
Y
H
A
G
E
W
F
--
E
SP
A
E
Q
L
P
V
R
Y
A
G
Y
S
S
C
F
R
R
E
A
G
S
H
G
K
D
A
W
G
I
F
R
V
H
A
F
E
K
I
E
Q
F
V
L
T
E
P
--
E
--
K
S
W
E
--
E
F
D
R
M
I
G
C
S
E
E
F
Y
Q
S
L
G
L
P
Y
R
V
V
G
I
V
S
G
E
L
N
N
A
A
A
K
K
Y
D
L
E
A
W
F
P
F
Q
Q
E
Y
K
E
L
V
S
C
S
N
C
T
D
Y
Q
S
R
N
L
E
I
R
C
G
-
I
--
K
------------
K
--
Y
V
H
C
L
N
S
T
L
S
A
T
E
R
T
I
C
C
I
L
E
N
Y
Q
K
E
D
G
L
V
-
I
P
E
V
L
R
K
Y
I
----------------------
12
PsiBlast_PDB
77.48
31%
-64
- C1 -
3QO5
-
SYSC_CANAL
A:
[14-435]
---------------------------------
D
P
E
I
I
K
A
S
Q
K
K
R
G
------
D
S
V
E
L
V
D
------
E
I
I
A
E
Y
K
E
W
V
K
L
R
F
D
L
D
E
H
N
K
K
L
N
S
V
Q
K
E
I
G
K
R
F
---------------------------------------
D
L
I
A
E
K
E
K
------------
L
S
N
E
K
K
E
I
I
E
K
---
E
A
E
A
-----------
D
K
N
L
R
S
K
I
N
Q
----
V
G
N
I
V
H
E
S
V
-
V
D
S
Q
D
-
E
E
N
N
E
L
V
R
T
W
T
P
E
N
--------------------
Y
K
---------------------
K
P
E
-
Q
IAAATGAPAKLS
H
H
E
V
L
L
R
L
D
G
Y
D
P
E
R
G
V
-
R
I
V
G
H
R
G
Y
F
L
R
N
Y
G
V
F
L
N
Q
A
L
I
N
Y
G
L
L
F
L
S
S
K
G
Y
V
P
L
Q
A
P
V
M
M
N
K
E
V
M
A
K
T
A
Q
L
S
Q
F
D
E
E
L
Y
K
V
I
DG--------
E
D
--
E
K
-
Y
L
I
A
T
S
E
Q
P
I
S
A
Y
H
A
G
E
W
F
--
E
SP
A
E
Q
L
P
V
R
Y
A
G
Y
S
S
C
F
R
R
E
A
G
-----
A
W
G
I
F
R
V
H
A
F
E
K
I
E
Q
F
V
L
T
E
P
--
E
--
K
S
W
E
--
E
F
D
R
M
I
G
C
S
E
E
F
Y
Q
S
L
G
L
P
Y
R
V
V
G
I
V
S
G
E
L
N
N
A
A
A
K
K
Y
D
L
E
A
W
F
P
F
Q
Q
E
Y
K
E
L
V
S
C
S
N
C
T
D
Y
Q
S
R
N
L
E
I
R
C
G
-
I
---------------E
K
K
Y
V
H
C
L
N
S
T
L
S
A
T
E
R
T
I
C
C
I
L
E
N
Y
Q
K
E
D
G
L
V
-
I
P
E
V
L
R
K
Y
I
----------------------
14
PsiBlast_PDB
77.39
29%
-77
- C1 -
3VBB
2
SYSC_HUMAN
A:
[33-460]
------------------------------------------------------
V
D
Q
L
V
------
K
A
D
S
E
W
R
R
C
R
---
F
R
A
D
N
L
N
K
L
K
N
L
C
S
K
T
I
G
E
K
M
K
K
K
--------
E
----------------------------
D
E
S
V
P
E
N
VLSFDDLT
A
D
A
L
A
N
L
K
V
S
Q
I
K
K
V
R
L
L
I
D
E
A
ILKC
D
A
E
R
I
K
L
E
A
E
R
F
E
N
L
R
E
----
I
G
N
L
L
H
P
S
V
P
I
S
N
D
E
-
D
V
D
N
K
V
E
R
I
W
G
--
D
--------------------
C
T
--------------------
V
R
K
K
Y
S
------------
H
V
D
L
V
V
M
V
D
G
F
E
G
E
K
G
A
-
V
V
A
G
S
R
G
Y
F
L
K
G
V
L
V
F
L
E
Q
A
L
I
Q
Y
A
L
R
T
L
G
S
R
G
Y
I
P
I
Y
T
P
F
F
M
R
K
E
V
M
Q
E
V
A
Q
L
S
-
F
D
E
E
L
Y
K
V
I--------------
D
E
K
Y
L
I
A
T
S
E
Q
P
I
A
A
L
H
R
D
E
W
L
--
R
--
P
E
D
L
P
I
K
Y
A
G
L
S
T
C
F
R
Q
E
V
G
S
----
T
R
G
I
F
R
V
H
Q
F
E
K
I
E
Q
F
V
Y
S
S
P
--
H
--
D
N
K
S
W
E
M
F
E
E
M
I
T
T
A
E
E
F
Y
Q
S
L
G
I
P
Y
H
I
V
N
I
V
S
G
S
L
N
H
A
A
S
K
K
L
D
L
E
A
W
F
P
G
S
G
A
F
R
E
L
V
S
C
S
N
C
T
D
Y
Q
A
R
R
L
R
I
R
Y
G
-
Q
--
T
-------M
D
K
V
E
---
F
V
H
M
L
N
A
T
M
C
A
T
T
R
T
I
C
A
I
L
E
N
Y
Q
T
E
K
G
-
I
T
V
P
E
K
L
K
E
F
M
----------------------
10
PsiBlast_PDB
77.02
31%
-61
- C1 -
3QO7
1
SYSC_CANAL
A:
[14-435]
---------------------------------
D
P
E
I
I
K
A
S
Q
K
K
R
G
------
D
S
V
E
L
V
D
------
E
I
I
A
E
Y
K
E
W
V
K
L
R
F
D
L
D
E
H
N
K
K
L
N
S
V
Q
K
E
I
G
K
R
F
K
A
K
--------
E
D
A
------------------------
K
D
L
I
A
E
K
E
K
------------
L
S
N
E
K
K
E
I
I
E
K
---
E
A
E
A
-----------
D
K
N
L
R
S
K
I
N
Q
----
V
G
N
I
V
H
E
S
V
-
V
D
S
Q
D
-
E
E
N
N
E
L
V
R
T
W
T
P
E
N
--------------------
Y
K
---------------------
K
P
E
-
Q
IAAATGAPAKLS
H
H
E
V
L
L
R
L
D
G
Y
D
P
E
R
G
V
-
R
I
V
G
H
R
G
Y
F
L
R
N
Y
G
V
F
L
N
Q
A
L
I
N
Y
G
L
S
F
L
S
S
K
G
Y
V
P
L
Q
A
P
V
M
M
N
K
E
V
M
A
K
T
A
Q
L
S
Q
F
D
E
E
L
Y
K
V
I
DG--------
E
D
--
E
K
-
Y
L
I
A
T
S
E
Q
P
I
S
A
Y
H
A
G
E
W
F
--
E
SP
A
E
Q
L
P
V
R
Y
A
G
Y
S
S
C
F
R
R
E
A
G
-----
A
W
G
I
F
R
V
H
A
F
E
K
I
E
Q
F
V
L
T
E
P
--
E
--
K
S
W
E
--
E
F
D
R
M
I
G
C
S
E
E
F
Y
Q
S
L
G
L
P
Y
R
V
V
G
I
V
S
G
E
L
N
N
A
A
A
K
K
Y
D
L
E
A
W
F
P
F
Q
Q
E
Y
K
E
L
V
S
C
S
N
C
T
D
Y
Q
S
R
N
L
E
I
R
C
G
-
I
---------------E
K
K
Y
V
H
C
L
N
S
T
L
S
A
T
E
R
T
I
C
C
I
L
E
N
Y
Q
K
E
D
G
L
V
-
I
P
E
V
L
R
K
Y
I
----------------------
13
PsiBlast_PDB
76.94
29%
-69
- C1 -
4L87
4
SYSC_HUMAN
A:
[32-459]
------------------------------------------------------
V
D
Q
L
V
------
K
A
D
S
E
W
R
R
C
R
---
F
R
A
D
N
L
N
K
L
K
N
L
C
S
K
T
I
G
E
K
M
K
K
K
--------
E
P
V
------------------------
G
D
D
E
S
V
P
E
N
VLSFDDLT
A
D
A
L
A
N
L
K
V
S
Q
I
K
K
V
R
L
L
I
D
E
A
I
L
K
C
D
A
E
R
I
K
L
E
A
E
R
F
E
N
L
R
E
----
I
G
N
L
L
H
P
S
V
P
I
S
N
D
E
-
D
V
D
N
K
V
E
R
I
W
G
--
D
--------------------
C
T
--------------------
V
R
K
K
Y
S
------------
H
V
D
L
V
V
M
V
D
G
F
E
G
E
K
G
A
-
V
V
A
G
S
R
G
Y
F
L
K
G
V
L
V
F
L
E
Q
A
L
I
Q
Y
A
L
R
T
L
G
S
R
G
Y
I
P
I
Y
T
P
F
F
M
R
K
E
V
M
Q
E
V
A
Q
L
S
Q
F
D
E
E
L
Y
K
V
I
G
KGSEKSDDN
S
Y
--
D
E
K
Y
L
I
A
T
S
E
Q
P
I
A
A
L
H
R
D
E
W
L
--
R
--
P
E
D
L
P
I
K
Y
A
G
L
S
T
C
F
R
Q
E
V
G
S
H
G
R
D
T
R
G
I
F
R
V
H
Q
F
E
K
I
E
Q
F
V
Y
S
S
P
--
H
--
D
N
K
S
W
E
M
F
E
E
M
I
T
T
A
E
E
F
Y
Q
S
L
G
I
P
Y
H
I
V
N
I
V
S
G
S
L
N
H
A
A
S
K
K
L
D
L
E
A
W
F
P
G
S
G
A
F
R
E
L
V
S
C
S
N
C
T
D
Y
Q
A
R
R
L
R
I
R
Y
G
-
Q
--
T
--
K
--
K
M
MD
K
V
E
---
F
V
H
M
L
N
A
T
M
C
A
T
T
R
T
I
C
A
I
L
E
N
Y
Q
T
E
K
G
-
I
T
V
P
E
K
L
K
E
F
M
----------------------
36
HHSearch
76.54
30%
-63
- C1 -
3QNE
-
SYSC_CANAL
A:
[1-435]
----------------
M
L
D
I
N
A
F
L
VEKG
G
----
D
P
E
I
I
K
A
S
Q
K
K
R
G
-
D
S
--
V
E
L
V
D
E
I
I
------
A
E
Y
K
E
W
V
K
L
R
---
F
D
L
D
E
H
N
K
K
L
N
S
V
Q
K
E
I
G
K
R
F
K
A
K
--------
E
D
A
------------------------
K
D
L
I
A
E
K
E
K
------------
L
S
N
E
K
K
E
I
I
E
K
---
E
A
E
A
-----------
D
K
N
L
R
S
K
I
N
Q
----
V
G
N
I
V
H
E
S
V
V
D
S
Q
D
E
-
E
N
N
E
L
V
R
T
W
T
P
E
N
Y
KKPEQIAAAT----------
G
A
--------------------
P
A
K
L
-
S
------------
H
H
E
V
L
L
R
L
D
G
Y
D
P
E
R
G
V
-
R
I
V
G
H
R
G
Y
F
L
R
N
Y
G
V
F
L
N
Q
A
L
I
N
Y
G
L
S
F
L
S
S
K
G
Y
V
P
L
Q
A
P
V
M
M
N
K
E
V
M
A
K
T
A
Q
L
S
Q
F
D
E
E
L
Y
K
V
-----------
I
D
GE
D
E
K
Y
L
I
A
T
S
E
Q
P
I
S
A
Y
H
A
G
E
W
F
ES
P
--
A
E
Q
L
P
V
R
Y
A
G
Y
S
S
C
F
R
R
E
A
G
-----
A
W
G
I
F
R
V
H
A
F
E
K
I
E
Q
F
V
L
T
E
P
--
E
--
K
S
W
E
--
E
F
D
R
M
I
G
C
S
E
E
F
Y
Q
S
L
G
L
P
Y
R
V
V
G
I
V
S
G
E
L
N
N
A
A
A
K
K
Y
D
L
E
A
W
F
P
F
Q
Q
E
Y
K
E
L
V
S
C
S
N
C
T
D
Y
Q
S
R
N
L
E
I
R
C
G
-
I
--------
E
K
----
K
---
Y
V
H
C
L
N
S
T
L
S
A
T
E
R
T
I
C
C
I
L
E
N
Y
Q
K
E
D
G
-
L
V
I
P
E
V
L
R
K
Y
I
----------------------
9
PsiBlast_PDB
76.35
31%
-62
- C1 -
3QNE
-
SYSC_CANAL
A:
[14-435]
---------------------------------
D
P
E
I
I
K
A
S
Q
K
K
R
G
------
D
S
V
E
L
V
D
------
E
I
I
A
E
Y
K
E
W
V
K
L
R
F
D
L
D
E
H
N
K
K
L
N
S
V
Q
K
E
I
G
K
R
F
K
A
K
--------
E
D
A
------------------------
K
D
L
I
A
E
K
E
K
------------
L
S
N
E
K
K
E
I
I
E
K
---
E
A
E
A
-----------
D
K
N
L
R
S
K
I
N
Q
----
V
G
N
I
V
H
E
S
V
-
V
D
S
Q
D
-
E
E
N
N
E
L
V
R
T
W
T
P
E
N
--------------------
Y
K
---------------------
K
P
E
-
Q
IAAATGAPAKLS
H
H
E
V
L
L
R
L
D
G
Y
D
P
E
R
G
V
-
R
I
V
G
H
R
G
Y
F
L
R
N
Y
G
V
F
L
N
Q
A
L
I
N
Y
G
L
S
F
L
S
S
K
G
Y
V
P
L
Q
A
P
V
M
M
N
K
E
V
M
A
K
T
A
Q
L
S
Q
F
D
E
E
L
Y
K
V
I
DG--------
E
D
--
E
K
-
Y
L
I
A
T
S
E
Q
P
I
S
A
Y
H
A
G
E
W
F
--
E
SP
A
E
Q
L
P
V
R
Y
A
G
Y
S
S
C
F
R
R
E
A
G
-----
A
W
G
I
F
R
V
H
A
F
E
K
I
E
Q
F
V
L
T
E
P
--
E
--
K
S
W
E
--
E
F
D
R
M
I
G
C
S
E
E
F
Y
Q
S
L
G
L
P
Y
R
V
V
G
I
V
S
G
E
L
N
N
A
A
A
K
K
Y
D
L
E
A
W
F
P
F
Q
Q
E
Y
K
E
L
V
S
C
S
N
C
T
D
Y
Q
S
R
N
L
E
I
R
C
G
-
I
---------------E
K
K
Y
V
H
C
L
N
S
T
L
S
A
T
E
R
T
I
C
C
I
L
E
N
Y
Q
K
E
D
G
L
V
-
I
P
E
V
L
R
K
Y
I
----------------------
23
PsiBlast_CBE
75.56
37%
-69
- C1 -
3ERR
1
SYS_THET2
B:
[172-521]
-----------------------------------------------------------------------------------------------------
Q
--------
L
N
Y
------------------------
A
D
M
L
K
R
V
E
P
------------
L
R
N
E
L
Q
K
L
E
D
D
---
A
K
D
N
-----------
Q
Q
K
L
E
A
L
L
L
Q
----
V
P
L
P
P
W
P
G
A
P
V
G
G
-
E
-
E
A
N
R
E
I
K
R
V
G
G
P
P
E
--------------------
F
S
--------------------
F
P
P
L
-
D
------------
H
V
A
L
M
E
K
N
G
W
--
W
E
P
R
I
S
Q
V
S
G
S
R
S
Y
A
L
K
G
D
L
A
L
Y
E
L
A
L
L
R
F
A
M
D
F
M
A
R
R
G
F
L
P
M
T
L
P
S
Y
A
R
E
K
A
F
L
G
T
G
H
F
P
A
Y
R
D
Q
V
W
A
I
-----------
A
E
--
T
D
L
Y
L
T
G
T
A
E
V
V
L
N
A
L
H
S
G
E
I
L
--
P
--
Y
E
A
L
P
L
R
Y
A
G
Y
A
P
A
F
R
S
E
A
G
S
F
G
K
D
V
R
G
L
M
R
V
H
Q
F
H
K
V
E
Q
Y
V
L
T
E
A
SL
E
--
A
S
D
R
--
A
F
Q
E
L
L
E
N
A
E
E
I
L
R
L
L
E
L
P
Y
R
L
V
E
V
A
T
G
D
M
G
P
G
K
W
R
Q
V
D
I
E
V
Y
L
P
S
E
G
R
Y
R
E
T
H
S
C
S
A
L
L
D
W
Q
A
R
R
A
N
L
R
Y
R
-
D
--
P
--
E
G-
R
V
----
R
---
Y
A
Y
T
L
N
N
T
A
L
A
T
P
R
I
L
A
M
L
L
E
N
H
Q
L
Q
D
G
R
V
R
V
P
Q
A
L
I
P
Y
M
----------------------
6
PsiBlast_PDB
75.39
38%
-72
- C1 -
1SRY
-
SYS_THET2
A:
[76-412]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
E
A
K
R
---
L
E
E
A
-----------
L
R
E
K
E
A
R
L
E
A
L
L
L
Q
V
P
L
P
P
W
P
G
A
P
V
G
G
-
E
-
E
A
N
R
E
I
K
R
V
G
G
P
P
E
--------------------
F
S
--------------------
F
P
P
L
-
D
------------
H
V
A
L
M
E
K
N
G
W
--
W
E
P
R
I
S
Q
V
S
G
S
R
S
Y
A
L
K
G
D
L
A
L
Y
E
L
A
L
L
R
F
A
M
D
F
M
A
R
R
G
F
L
P
M
T
L
P
S
Y
A
R
E
K
A
F
L
G
T
G
H
F
P
A
Y
R
D
Q
V
W
A
I
-----------
A
E
--
T
D
L
Y
L
T
G
T
A
E
V
V
L
N
A
L
H
S
G
E
I
L
--
P
--
Y
E
A
L
P
L
R
Y
A
G
Y
A
P
A
F
R
S
E
A
G
S
F
G
K
D
V
R
G
L
M
R
V
H
Q
F
H
K
V
E
Q
Y
V
L
T
E
A
S
L
E
--
A
S
D
R
--
A
F
Q
E
L
L
E
N
A
E
E
I
L
R
L
L
E
L
P
Y
R
L
V
E
V
A
T
G
D
M
G
P
G
K
W
R
Q
V
D
I
E
V
Y
L
P
S
E
G
R
Y
R
E
T
H
S
C
S
A
L
L
D
W
Q
A
R
R
A
N
L
R
Y
R
-
D
--
P
--
E
G-
R
V
----
R
---
Y
A
Y
T
L
N
N
T
A
L
A
T
P
R
I
L
A
M
L
L
E
N
H
Q
L
Q
D
G
R
V
R
V
P
Q
A
L
I
P
Y
M
----------------------
53
Fugue
75.23
27%
-63
- C1 -
1WLE
1
SYSM_BOVIN
A:
[24-490]
RN
L
L
Y
E
H
A
R
E
GYSALP
L
L
D
M
E
S
L
C
----
A
----
Y
P
E
D
A
A
R
A
L
D
L
R
K
G
E
L
R
-
S
K
D
L
P
G
I
I
------
S
T
W
Q
E
L
R
Q
L
R
---
E
Q
I
R
S
L
E
E
E
K
E
A
V
T
E
A
V
R
A
L
V
V
N
Q
DNSQVQQD
P
Q
Y
------------------------
Q
S
L
R
A
R
G
R
E
------------
I
R
K
Q
L
T
L
L
Y
P
K
---
E
A
Q
L
-----------
E
E
Q
F
Y
L
R
A
L
R
----
L
P
N
Q
T
H
P
D
V
P
V
G
-
D
E
-
S
Q
A
R
V
L
H
V
V
G
D
K
P
A
--------------------
F
S
--------------------
F
Q
P
R
-
G
------------
H
L
E
I
A
E
K
L
D
I
I
R
Q
K
R
L
S
-
H
V
S
G
H
R
S
Y
Y
L
R
G
A
G
A
L
L
Q
H
G
L
V
N
F
T
L
N
K
L
I
H
R
G
F
T
P
M
T
V
P
D
L
L
R
G
V
V
F
E
G
C
G
M
T
P
N
A
K
P
S
Q
I
Y
N
I
DPS-------
R
F
--
E
D
L
N
L
A
G
T
A
E
V
G
L
A
G
Y
F
M
D
H
S
V
--
A
--
F
R
D
L
P
I
R
M
V
C
S
S
T
C
Y
R
A
E
T
D
T
---
G
P
W
G
L
Y
R
V
H
H
F
T
K
V
E
M
F
G
V
T
G
P
G
L
E
--
Q
S
S
E
--
L
L
E
E
F
L
S
L
Q
M
E
I
L
T
E
L
G
L
H
F
R
V
L
D
M
P
T
Q
E
L
G
L
P
A
Y
R
K
F
D
I
E
A
W
M
P
G
R
G
R
F
G
E
V
T
S
A
S
N
C
T
D
F
Q
S
R
R
L
H
I
M
F
Q
T
E
--
A
--
G
--
E
L
----
Q
---
F
A
H
T
V
N
A
T
G
C
A
V
P
R
L
L
I
A
L
L
E
S
Y
Q
Q
K
D
G
S
V
L
V
P
P
A
L
Q
P
Y
L
GTDRITTPTHVPLQYIGPNQPQ
37
HHSearch
74.85
38%
-68
- C1 -
3ERR
1
DYHC1_MOUSE (first)
A:
[179-521]
--------------------------------------------------------------------------------------------------------------------------------------------
L
K
R
V
E
P
------------
L
R
N
E
L
Q
K
L
E
D
D
---
A
K
D
N
-----------
Q
Q
K
L
E
A
L
L
L
Q
----
V
P
L
P
P
W
P
G
A
P
V
G
G
E
E
--
A
N
R
E
I
K
R
V
G
G
P
P
E
--------------------
F
S
--------------------
F
P
P
L
-
D
------------
H
V
A
L
M
E
K
N
G
W
W
E
P
-
R
I
S
-
Q
V
S
G
S
R
S
Y
A
L
K
G
D
L
A
L
Y
E
L
A
L
L
R
F
A
M
D
F
M
A
R
R
G
F
L
P
M
T
L
P
S
Y
A
R
E
K
A
F
L
G
T
G
H
F
P
A
Y
R
D
Q
V
W
A
I
-----------
A
E
--
T
D
L
Y
L
T
G
T
A
E
V
V
L
N
A
L
H
S
G
E
I
L
--
P
--
Y
E
A
L
P
L
R
Y
A
G
Y
A
P
A
F
R
S
E
A
G
S
F
G
K
D
V
R
G
L
M
R
V
H
Q
F
H
K
V
E
Q
Y
V
L
T
E
A
S
L
E
--
A
S
D
R
--
A
F
Q
E
L
L
E
N
A
E
E
I
L
R
L
L
E
L
P
Y
R
L
V
E
V
A
T
G
D
M
G
P
G
K
W
R
Q
V
D
I
E
V
Y
L
P
S
E
G
R
Y
R
E
T
H
S
C
S
A
L
L
D
W
Q
A
R
R
A
N
L
R
Y
R
-
D
--
P
E-
G
--
R
V
----
R
---
Y
A
Y
T
L
N
N
T
A
L
A
T
P
R
I
L
A
M
L
L
E
N
H
Q
L
Q
D
G
R
V
R
V
P
Q
A
L
I
P
Y
M
----------------------
8
PsiBlast_PDB
74.80
38%
-68
- C1 -
1SET
1
SYS_THET2
A:
[76-412]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
E
A
K
R
---
L
E
E
A
-----------
L
R
E
K
E
A
R
L
E
A
L
L
L
Q
V
P
L
P
P
W
P
G
A
P
V
G
G
-
E
-
E
A
N
R
E
I
K
R
V
G
G
P
P
E
--------------------
F
S
--------------------
F
P
P
L
-
D
------------
H
V
A
L
M
E
K
N
G
W
--
W
E
P
R
I
S
Q
V
S
G
S
R
S
Y
A
L
K
G
D
L
A
L
Y
E
L
A
L
L
R
F
A
M
D
F
M
A
R
R
G
F
L
P
M
T
L
P
S
Y
A
R
E
K
A
F
L
G
T
G
H
F
P
A
Y
R
D
Q
V
W
A
I
-----------
A
E
--
T
D
L
Y
L
T
G
T
A
E
V
V
L
N
A
L
H
S
G
E
I
L
--
P
--
Y
E
A
L
P
L
R
Y
A
G
Y
A
P
A
F
R
S
E
A
G
S
F
G
K
D
V
R
G
L
M
R
V
H
Q
F
H
K
V
E
Q
Y
V
L
T
E
A
S
L
E
--
A
S
D
R
--
A
F
Q
E
L
L
E
N
A
E
E
I
L
R
L
L
E
L
P
Y
R
L
V
E
V
A
T
G
D
M
G
P
G
K
W
R
Q
V
D
I
E
V
Y
L
P
S
E
G
R
Y
R
E
T
H
S
C
S
A
L
L
D
W
Q
A
R
R
A
N
L
R
Y
R
-
D
--
P
--
E
G-
R
V
----
R
---
Y
A
Y
T
L
N
N
T
A
L
A
T
P
R
I
L
A
M
L
L
E
N
H
Q
L
Q
D
G
R
V
R
V
P
Q
A
L
I
P
Y
M
----------------------
5
PsiBlast_PDB
74.58
37%
-67
- C1 -
3ERR
1
DYHC1_MOUSE (first)
A:
[172-521]
-----------------------------------------------------------------------------------------------------
Q
--------
L
N
Y
------------------------
A
D
M
L
K
R
V
E
P
------------
L
R
N
E
L
Q
K
L
E
D
D
---
A
K
D
N
-----------
Q
Q
K
L
E
A
L
L
L
Q
----
V
P
L
P
P
W
P
G
A
P
V
G
G
-
E
-
E
A
N
R
E
I
K
R
V
G
G
P
P
E
--------------------
F
S
--------------------
F
P
P
L
-
D
------------
H
V
A
L
M
E
K
N
G
W
--
W
E
P
R
I
S
Q
V
S
G
S
R
S
Y
A
L
K
G
D
L
A
L
Y
E
L
A
L
L
R
F
A
M
D
F
M
A
R
R
G
F
L
P
M
T
L
P
S
Y
A
R
E
K
A
F
L
G
T
G
H
F
P
A
Y
R
D
Q
V
W
A
I
-----------
A
E
--
T
D
L
Y
L
T
G
T
A
E
V
V
L
N
A
L
H
S
G
E
I
L
--
P
--
Y
E
A
L
P
L
R
Y
A
G
Y
A
P
A
F
R
S
E
A
G
S
F
G
K
D
V
R
G
L
M
R
V
H
Q
F
H
K
V
E
Q
Y
V
L
T
E
A
S
L
E
--
A
S
D
R
--
A
F
Q
E
L
L
E
N
A
E
E
I
L
R
L
L
E
L
P
Y
R
L
V
E
V
A
T
G
D
M
G
P
G
K
W
R
Q
V
D
I
E
V
Y
L
P
S
E
G
R
Y
R
E
T
H
S
C
S
A
L
L
D
W
Q
A
R
R
A
N
L
R
Y
R
-
D
--
P
--
E
G-
R
V
----
R
---
Y
A
Y
T
L
N
N
T
A
L
A
T
P
R
I
L
A
M
L
L
E
N
H
Q
L
Q
D
G
R
V
R
V
P
Q
A
L
I
P
Y
M
----------------------
7
PsiBlast_PDB
74.52
38%
-69
- C1 -
1SES
1
SYS_THET2
A:
[76-412]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
E
A
K
R
---
L
E
E
A
-----------
L
R
E
K
E
A
R
L
E
A
L
L
L
Q
V
P
L
P
P
W
P
G
A
P
V
G
G
-
E
-
E
A
N
R
E
I
K
R
V
G
G
P
P
E
--------------------
F
S
--------------------
F
P
P
L
-
D
------------
H
V
A
L
M
E
K
N
G
W
--
W
E
P
R
I
S
Q
V
S
G
S
R
S
Y
A
L
K
G
D
L
A
L
Y
E
L
A
L
L
R
F
A
M
D
F
M
A
R
R
G
F
L
P
M
T
L
P
S
Y
A
R
E
K
A
F
L
G
T
G
H
F
P
A
Y
R
D
Q
V
W
A
I
-----------
A
E
--
T
D
L
Y
L
T
G
T
A
E
V
V
L
N
A
L
H
S
G
E
I
L
--
P
--
Y
E
A
L
P
L
R
Y
A
G
Y
A
P
A
F
R
S
E
A
G
S
F
G
K
D
V
R
G
L
M
R
V
H
Q
F
H
K
V
E
Q
Y
V
L
T
E
A
S
L
E
--
A
S
D
R
--
A
F
Q
E
L
L
E
N
A
E
E
I
L
R
L
L
E
L
P
Y
R
L
V
E
V
A
T
G
D
M
G
P
G
K
W
R
Q
V
D
I
E
V
Y
L
P
S
E
G
R
Y
R
E
T
H
S
C
S
A
L
L
D
W
Q
A
R
R
A
N
L
R
Y
R
-
D
--
P
--
E
G-
R
V
----
R
---
Y
A
Y
T
L
N
N
T
A
L
A
T
P
R
I
L
A
M
L
L
E
N
H
Q
L
Q
D
G
R
V
R
V
P
Q
A
L
I
P
Y
M
----------------------
24
PsiBlast_CBE
74.48
38%
-66
- C1 -
1SET
1
SYS_THET2
B:
[76-412]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
E
A
K
R
---
L
E
E
A
-----------
L
R
E
K
E
A
R
L
E
A
LLLQ
V
P
L
P
P
W
P
G
A
P
V
G
G
-
E
-
E
A
N
R
E
I
K
R
V
G
G
P
P
E
--------------------
F
S
--------------------
F
P
P
L
-
D
------------
H
V
A
L
M
E
K
N
G
W
--
W
E
P
R
I
S
Q
V
S
G
S
R
S
Y
A
L
K
G
D
L
A
L
Y
E
L
A
L
L
R
F
A
M
D
F
M
A
R
R
G
F
L
P
M
T
L
P
S
Y
A
R
E
K
A
F
L
G
T
G
H
F
P
A
Y
R
D
Q
V
W
A
I
-----------
A
E
--
T
D
L
Y
L
T
G
T
A
E
V
V
L
N
A
L
H
S
G
E
I
L
--
P
--
Y
E
A
L
P
L
R
Y
A
G
Y
A
P
A
F
R
S
E
A
G
S
F
G
K
D
V
R
G
L
M
R
V
H
Q
F
H
K
V
E
Q
Y
V
L
T
E
A
SL
E
--
A
S
D
R
--
A
F
Q
E
L
L
E
N
A
E
E
I
L
R
L
L
E
L
P
Y
R
L
V
E
V
A
T
G
D
M
G
P
G
K
W
R
Q
V
D
I
E
V
Y
L
P
S
E
G
R
Y
R
E
T
H
S
C
S
A
L
L
D
W
Q
A
R
R
A
N
L
R
Y
R
-
D
--
P
--
E
G-
R
V
----
R
---
Y
A
Y
T
L
N
N
T
A
L
A
T
P
R
I
L
A
M
L
L
E
N
H
Q
L
Q
D
G
R
V
R
V
P
Q
A
L
I
P
Y
M
----------------------
25
PsiBlast_CBE
73.86
38%
-65
- C1 -
1SES
1
SYS_THET2
B:
[76-412]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
E
A
K
R
---
L
E
E
A
-----------
L
R
E
K
E
A
R
L
E
A
LLLQ
V
P
L
P
P
W
P
G
A
P
V
G
G
-
E
-
E
A
N
R
E
I
K
R
V
G
G
P
P
E
--------------------
F
S
--------------------
F
P
P
L
-
D
------------
H
V
A
L
M
E
K
N
G
W
--
W
E
P
R
I
S
Q
V
S
G
S
R
S
Y
A
L
K
G
D
L
A
L
Y
E
L
A
L
L
R
F
A
M
D
F
M
A
R
R
G
F
L
P
M
T
L
P
S
Y
A
R
E
K
A
F
L
G
T
G
H
F
P
A
Y
R
D
Q
V
W
A
I
-----------
A
E
--
T
D
L
Y
L
T
G
T
A
E
V
V
L
N
A
L
H
S
G
E
I
L
--
P
--
Y
E
A
L
P
L
R
Y
A
G
Y
A
P
A
F
R
S
E
A
G
S
F
G
K
D
V
R
G
L
M
R
V
H
Q
F
H
K
V
E
Q
Y
V
L
T
E
A
SL
E
--
A
S
D
R
--
A
F
Q
E
L
L
E
N
A
E
E
I
L
R
L
L
E
L
P
Y
R
L
V
E
V
A
T
G
D
M
G
P
G
K
W
R
Q
V
D
I
E
V
Y
L
P
S
E
G
R
Y
R
E
T
H
S
C
S
A
L
L
D
W
Q
A
R
R
A
N
L
R
Y
R
-
D
--
P
--
E
G-
R
V
----
R
---
Y
A
Y
T
L
N
N
T
A
L
A
T
P
R
I
L
A
M
L
L
E
N
H
Q
L
Q
D
G
R
V
R
V
P
Q
A
L
I
P
Y
M
----------------------