@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_1428: (2015-12-23 )
MTIGLVKESMDLESRVALVPDDVALIAQKGVEVLVQNSAGANSGYSNEAYESVGAKIVDSKTAWGQDLVVKCKEPLEHEYPLLKEKATLFSYLDLAYQKSLCEMFINKKITSICTETIAGPKNDYPILAPMSVVAGRLAAHLVQHYLLALEHVKGFMGKGVMLGGLSGAQRAKIVVIGGGVVGMESAKVLSQMGAKVTILELDYAKLQNHPYYHLYDLEVLSVNEANIIQALNGAVGLVGAVLVTASQTPKVILRRHLKYMQKQGVVIDVACDLGGCIETIRQTSHSNPVYVEEDLLHYGVPNMPGIVAKTSSTAYSHASVPYLLYYLEHGLKGFLTANTKIVANTLGGLSAYNGYITQEGIAKAFNLAFKSPLEILKEL
Atome Classification :
(21 SA)
.........10........20........30........40........50........60....--..-...70.......-.80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200----........----------.210------.......-..220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MTI
G
L
VKESMDL
E
S
R
V
ALVP
D
D
V
A
L
I
A
QK
G
V
E
V
L
V
QNSAGANSGYS
N
E
A
Y
E
S
VG
A
K
I
VDS-KTAW--GQ-
D
L
V
V
K
C
KEPLEH-EY
P
L
L
K
E
K
A
T
L
F
S
Y
L
D
L
A
Y
Q
K
S
L
C
E
M
F
I
N
K
K
I
T
S
I
C
T
E
TIAGPKNDY
P
I
L
A
P
M
S
V
V
A
G
R
L
A
A
H
L
V
Q
H
Y
L
L
A
L
E
H
V
K
G
F
MGK
G
V
M
LGGLSGA
Q
R
A
K
I
V
V
IGGGVVG
M
E
S
A
K
V
L
S
QMG
A
K
V
T
I
L
------
E
L
D
Y
A
K
LQ----------NH--------P
Y
Y
H
L
Y
D
-
L
E
V
L
SVN
E
A
N
I
I
Q
A
L
N
G
A
V
G
L
V
G
A
V
L
VTASQ
T
P
K
V
I
L
R
R
H
L
K
Y
M
Q
KQ
G
V
V
I
D
VACDL
G
G
C
I
E
T
I
R
QTSHSN
P
V
Y
V
E
E
D
L
L
H
YGVPNMPG
I
V
AKTSSTAYSHAS
V
P
Y
L
L
Y
Y
L
E
HGL
K
G
FLTAN
T
K
I
V
A
NTLGGL
S
A
YNGYI
T
Q
E
G
I
A
K
A
F
N
L
A
F
K
S
P
L
E
I
L
KEL
117
HHSearch
87.68
42%
-116
- C2 -
2EEZ
-
?
A:
[1-368]
M
V
I
G
V
P
K
E
I
K
T
L
E
N
R
V
A
L
T
P
G
G
V
E
S
L
V
R
R
G
H
T
V
L
V
E
R
G
A
G
E
G
S
G
L
S
D
A
E
Y
A
R
A
G
A
E
L
V
G
R
-
E
E
A
W
--
G
A
-
E
M
V
V
K
V
K
E
P
L
P
E
-
E
Y
G
F
L
R
E
G
L
I
L
F
T
Y
L
H
L
A
A
D
R
G
L
T
E
A
M
L
R
S
G
V
T
G
I
A
Y
E
T
V
Q
L
P
D
G
T
L
P
L
L
V
P
M
S
E
V
A
G
R
M
A
P
Q
V
G
A
Q
F
L
E
-
K
----
P
K
G
G
R
G
V
L
L
G
G
V
P
G
V
A
P
A
S
V
V
I
L
G
G
G
T
V
G
T
N
A
A
K
I
A
L
G
M
G
A
Q
V
T
I
L
------
D
V
N
H
K
R
L
Q
----------
Y
L
--------
D
D
V
F
G
G
R
-
V
I
T
L
T
A
T
E
A
N
I
K
K
S
V
Q
H
A
D
L
L
I
G
A
V
L
-------
K
L
V
T
R
D
M
L
S
L
M
K
E
G
A
V
I
V
D
V
A
-------------------
Y
V
V
D
G
V
V
H
Y
G
V
A
N
M
P
G
A
V
P
R
T
S
T
F
A
L
T
N
Q
T
L
P
Y
V
L
K
L
A
E
K
G
L
D
A
-
L
L
E
D
A
A
L
----
L
K
G
L
N
T
H
K
G
R
L
T
H
P
G
V
A
E
A
F
G
L
P
Y
T
P
P
E
E
A
L
R
G
-
1
PsiBlast_PDB
86.70
40%
-113
- C2 -
2EEZ
-
?
A:
[1-368]
M
V
I
G
V
P
K
E
I
K
T
L
E
N
R
V
A
L
T
P
G
G
V
E
S
L
V
R
R
G
H
T
V
L
V
E
R
G
A
G
E
G
S
G
L
S
D
A
E
Y
A
R
A
G
A
E
L
V
G
R
-
E
E
A
W
--
G
A
-
E
M
V
V
K
V
K
E
P
L
P
E
-
E
Y
G
F
L
R
E
G
L
I
L
F
T
Y
L
H
L
A
A
D
R
G
L
T
E
A
M
L
R
S
G
V
T
G
I
A
Y
E
T
V
Q
L
P
D
G
T
L
P
L
L
V
P
M
S
E
V
A
G
R
M
A
P
Q
V
G
A
Q
F
---
L
E
K
P
K
G
G
R
G
V
L
L
G
G
--
V
P
G
V
A
P
A
S
V
V
I
L
G
G
G
T
V
G
T
N
A
A
K
I
A
L
G
M
G
A
Q
V
T
I
L
------
D
V
N
H
K
R
L
Q
----------
Y
L
--------
D
D
V
F
G
G
R
-
V
I
T
L
T
A
T
E
A
N
I
K
K
S
V
Q
H
A
D
L
L
I
G
A
V
L
-------
K
L
V
T
R
D
M
L
S
L
M
K
E
G
A
V
I
V
D
V
A
-------------------
Y
V
V
D
G
V
V
H
Y
G
V
A
N
M
P
G
A
V
P
R
T
S
T
F
A
L
T
N
Q
T
L
P
Y
V
L
K
L
A
E
K
G
L
D
A
L
L
E
D
-----
A
A
L
L
K
G
L
N
T
H
K
G
R
L
T
H
P
G
V
A
E
A
F
G
L
P
Y
T
P
P
E
E
A
L
R
G
-
115
HHSearch
83.20
37%
-127
- C2 -
1PJC
1
?
A:
[1-359]
M
E
I
G
V
P
K
E
I
K
N
Q
E
F
R
V
G
L
S
P
S
S
V
R
T
L
V
E
A
G
H
T
V
F
I
E
T
Q
A
G
I
G
A
G
F
A
D
Q
D
Y
V
Q
A
G
A
Q
V
V
P
S
A
K
D
A
W
--
S
R
-
E
M
V
V
K
V
K
E
P
L
P
A
-
E
Y
D
L
M
Q
K
D
Q
L
L
F
T
Y
L
H
L
A
A
A
R
E
L
T
E
Q
L
M
R
V
G
L
T
A
I
A
Y
E
T
V
E
L
P
N
R
S
L
P
L
L
T
P
M
S
I
I
A
G
R
L
S
V
Q
F
G
A
R
F
L
E
-
R
----
Q
Q
G
G
R
G
V
L
L
G
G
V
P
G
V
K
P
G
K
V
V
I
L
G
G
G
V
V
G
T
E
A
A
K
M
A
V
G
L
G
A
Q
V
Q
I
F
------
D
I
N
V
E
R
L
S
----------
Y
L
--------
E
T
-
L
F
G
S
R
V
E
L
L
Y
S
N
S
A
E
I
E
T
A
V
A
E
A
D
L
L
I
G
A
V
L
V
P
G
R
R
A
P
I
L
V
P
A
S
L
V
E
Q
M
R
T
G
S
V
I
V
D
V
A
V
D
Q
G
G
C
V
E
T
L
H
P
T
S
H
T
Q
P
T
Y
E
V
F
G
V
V
H
Y
G
V
P
N
M
P
G
A
V
P
W
T
A
T
Q
A
L
N
N
S
T
L
P
Y
V
V
K
L
A
N
Q
G
L
K
-
A
L
E
T
D
D
A
L
----
A
K
G
L
N
V
Q
A
H
R
L
V
H
P
A
V
Q
Q
V
F
P
D
L
A
----------
6
PsiBlast_PDB
81.99
33%
-117
- C2 -
2VHX
2
DHA_MYCTU
A:
[1-370]
M
R
V
G
I
P
T
E
T
K
N
N
E
F
R
V
A
I
T
P
A
G
V
A
E
L
T
R
R
G
H
E
V
L
I
Q
A
G
A
G
E
G
S
A
I
T
D
A
D
F
K
A
A
G
A
Q
L
V
G
T
A
D
Q
V
W
--
A
D
A
D
L
L
L
K
V
K
E
P
I
A
A
-
E
Y
G
R
L
R
H
G
Q
I
L
F
T
F
L
H
L
A
A
S
R
A
C
T
D
A
L
L
D
S
G
T
T
S
I
A
Y
E
T
V
Q
T
A
D
G
A
L
P
L
L
A
P
M
S
E
V
A
G
R
L
A
A
Q
V
G
A
Y
H
L
M
R
T
Q
G
-----
G
R
G
V
L
M
G
G
V
P
G
V
E
P
A
D
V
V
V
I
G
A
G
T
A
G
Y
N
A
A
R
I
A
N
G
M
G
A
T
V
T
V
L
------
D
I
N
I
D
K
L
R
Q
L
D
A
E
F
C
GR
I
H
T
--------
R
Y
S
S
A
Y
E
-
L
E
G
-
A
V
K
R
A
D
L
V
---------
I
G
A
V
L
V
---
K
A
P
K
L
V
S
N
S
L
V
A
H
M
K
P
G
A
V
L
V
D
I
A
I
D
Q
G
G
C
F
E
G
S
R
P
T
T
Y
D
H
P
T
F
A
V
H
D
T
L
F
Y
C
V
A
N
M
P
A
S
V
P
K
T
S
T
Y
A
L
T
N
A
T
M
P
Y
V
L
E
L
A
D
H
G
W
R
A
A
C
R
S
N
P
A
L
A
K
----
G
L
S
T
H
E
G
A
L
L
S
E
R
V
A
T
D
L
G
V
P
F
T
E
P
A
S
V
L
A
--
22
PsiBlast_CBE
81.19
33%
-112
- C2 -
2VOJ
2
DHA_MYCTU
C:
[1-370]
M
R
V
G
I
P
T
E
T
K
N
N
E
F
R
V
A
I
T
P
A
G
V
A
E
L
T
R
R
G
H
E
V
L
I
Q
A
G
A
G
E
G
S
A
I
T
D
A
D
F
K
A
A
G
A
Q
L
V
G
T
A
D
Q
V
W
--
A
D
A
D
L
L
L
K
V
K
E
P
I
A
A
-
E
Y
G
R
L
R
H
G
Q
I
L
F
T
F
L
H
L
A
A
S
R
A
C
T
D
A
L
L
D
S
G
T
T
S
I
A
Y
E
T
V
Q
T
A
D
G
A
L
P
L
L
A
P
M
S
E
V
A
G
R
L
A
A
Q
V
G
A
Y
H
L
M
R
T
Q
G
-----
G
R
G
V
L
M
G
G
V
P
G
V
E
P
A
D
V
V
V
I
G
A
G
T
A
G
Y
N
A
A
R
I
A
N
G
M
G
A
T
V
T
V
L
------
D
I
N
I
D
K
L
R
QLDAEFCGRI
H
T
--------
R
Y
S
S
A
Y
E
-
L
E
G
-
A
V
K
R
A
D
L
V
---------
I
G
A
V
L
V
P
G
A
K
A
P
K
L
V
S
N
S
L
V
A
H
M
K
P
G
A
V
L
V
D
I
A
I
D
Q
G
G
C
F
E
G
S
R
P
T
T
Y
D
H
P
T
F
A
V
H
D
T
L
F
Y
C
V
A
N
M
P
A
S
V
P
K
T
S
T
Y
A
L
T
N
A
T
M
P
Y
V
L
E
L
A
D
H
G
W
R
A
A
C
R
S
N
P
A
L
A
K
----
G
L
S
T
H
E
G
A
L
L
S
E
R
V
A
T
D
L
G
V
P
F
T
E
P
A
S
V
L
A
--
7
PsiBlast_PDB
81.13
33%
-111
- C2 -
2VHZ
1
DHA_MYCTU
A:
[1-370]
M
R
V
G
I
P
T
E
T
K
N
N
E
F
R
V
A
I
T
P
A
G
V
A
E
L
T
R
R
G
H
E
V
L
I
Q
A
G
A
G
E
G
S
A
I
T
D
A
D
F
K
A
A
G
A
Q
L
V
G
T
A
D
Q
V
W
--
A
D
A
D
L
L
L
K
V
K
E
P
I
A
A
-
E
Y
G
R
L
R
H
G
Q
I
L
F
T
F
L
H
L
A
A
S
R
A
C
T
D
A
L
L
D
S
G
T
T
S
I
A
Y
E
T
V
Q
T
A
D
G
A
L
P
L
L
A
P
M
S
E
V
A
G
R
L
A
A
Q
V
G
A
Y
H
L
M
R
T
Q
G
-----
G
R
G
V
L
M
G
G
V
P
G
V
E
P
A
D
V
V
V
I
G
A
G
T
A
G
Y
N
A
A
R
I
A
N
G
M
G
A
T
V
T
V
L
------
D
I
N
I
D
K
L
R
Q
L
D
A
E
F
C
GR
I
H
T
--------
R
Y
S
S
A
Y
E
-
L
E
G
-
A
V
K
R
A
D
L
V
---------
I
G
A
V
L
V
P
G
A
K
A
P
K
L
V
S
N
S
L
V
A
H
M
K
P
G
A
V
L
V
D
I
A
I
D
Q
G
G
C
F
E
G
S
R
P
T
T
Y
D
H
P
T
F
A
V
H
D
T
L
F
Y
C
V
A
N
M
P
A
S
V
P
K
T
S
T
Y
A
L
T
N
A
T
M
P
Y
V
L
E
L
A
D
H
G
W
R
A
A
C
R
S
N
P
A
L
A
K
----
G
L
S
T
H
E
G
A
L
L
S
E
R
V
A
T
D
L
G
V
P
F
T
E
P
A
S
V
L
A
--
30
PsiBlast_CBE
81.11
33%
-116
- C2 -
2VHW
2
DHA_MYCTU
B:
[1-370]
M
R
V
G
I
P
T
E
T
K
N
N
E
F
R
V
A
I
T
P
A
G
V
A
E
L
T
R
R
G
H
E
V
L
I
Q
A
G
A
G
E
G
S
A
I
T
D
A
D
F
K
A
A
G
A
Q
L
V
G
T
A
D
Q
V
W
--
A
D
A
D
L
L
L
K
V
K
E
P
I
A
A
-
E
Y
G
R
L
R
H
G
Q
I
L
F
T
F
L
H
L
A
A
S
R
A
C
T
D
A
L
L
D
S
G
T
T
S
I
A
Y
E
T
V
Q
T
A
D
G
A
L
P
L
L
A
P
M
S
E
V
A
G
R
L
A
A
Q
V
G
A
Y
H
L
M
R
T
Q
G
-----
G
R
G
V
L
M
G
G
V
P
G
V
E
P
A
D
V
V
V
I
G
A
G
T
A
G
Y
N
A
A
R
I
A
N
G
M
G
A
T
V
T
V
L
------
D
I
N
I
D
K
L
R
QLDAEFCGRI
H
T
--------
R
Y
S
S
A
Y
E
-
L
E
G
-
A
V
K
R
A
D
L
V
---------
I
G
A
V
L
V
P
G
A
K
A
P
K
L
V
S
N
S
L
V
A
H
M
K
P
G
A
V
L
V
D
I
A
I
D
Q
G
G
C
F
E
G
S
R
P
T
T
Y
D
H
P
T
F
A
V
H
D
T
L
F
Y
C
V
A
N
M
P
A
S
V
P
K
T
S
T
Y
A
L
T
N
A
T
M
P
Y
V
L
E
L
A
D
H
G
W
R
A
A
C
R
S
N
P
A
L
A
K
----
G
L
S
T
H
E
G
A
L
L
S
E
R
V
A
T
D
L
G
V
P
F
T
E
P
A
S
V
L
---
4
PsiBlast_PDB
80.91
33%
-118
- C2 -
4LMP
8
?
A:
[1-370]
M
R
V
G
I
P
T
E
T
K
N
N
E
F
R
V
A
I
T
P
A
G
V
A
E
L
T
R
R
G
H
E
V
L
I
Q
A
G
A
G
E
G
S
A
I
T
D
A
D
F
K
A
A
G
A
Q
L
V
G
T
A
D
Q
V
W
--
A
D
A
D
L
L
L
K
V
K
E
P
I
A
A
-
E
Y
G
R
L
R
H
G
Q
I
L
F
T
F
L
H
L
A
A
S
R
A
C
T
D
A
L
L
D
S
G
T
T
S
I
A
Y
E
T
V
Q
T
A
D
G
A
L
P
L
L
A
P
M
S
E
V
A
G
R
L
A
A
Q
V
G
A
Y
H
L
M
R
T
Q
G
-----
G
R
G
V
L
M
G
G
V
P
G
V
E
P
A
D
V
V
V
I
G
A
G
T
A
G
Y
N
A
A
R
I
A
N
G
M
G
A
T
V
T
V
L
------
D
I
N
I
D
K
L
R
Q
L
D
A
E
F
C
GRI
H
T
--------
R
Y
S
S
A
Y
E
-
L
E
G
-
A
V
K
R
A
D
L
V
---------
I
G
A
V
L
V
P
G
A
K
A
P
K
L
V
S
N
S
L
V
A
H
M
K
P
G
A
V
L
V
D
I
A
I
D
Q
G
G
C
F
E
G
S
R
P
T
T
Y
D
H
P
T
F
A
V
H
D
T
L
F
Y
C
V
A
N
M
P
A
S
V
P
K
T
S
T
Y
A
L
T
N
A
T
M
P
Y
V
L
E
L
A
D
H
G
W
R
A
A
C
R
S
N
P
A
L
A
K
----
G
L
S
T
H
E
G
A
L
L
S
E
R
V
A
T
D
L
G
V
P
F
T
E
P
A
S
V
L
A
--
29
PsiBlast_CBE
80.87
33%
-114
- C2 -
2VHW
1
DHA_MYCTU
C:
[1-370]
M
R
V
G
I
P
T
E
T
K
N
N
E
F
R
V
A
I
T
P
A
G
V
A
E
L
T
R
R
G
H
E
V
L
I
Q
A
G
A
G
E
G
S
A
I
T
D
A
D
F
K
A
A
G
A
Q
L
V
G
T
A
D
Q
V
W
--
A
D
A
D
L
L
L
K
V
K
E
P
I
A
A
-
E
Y
G
R
L
R
H
G
Q
I
L
F
T
F
L
H
L
A
A
S
R
A
C
T
D
A
L
L
D
S
G
T
T
S
I
A
Y
E
T
V
Q
T
A
D
G
A
L
P
L
L
A
P
M
S
E
V
A
G
R
L
A
A
Q
V
G
A
Y
H
L
M
R
T
Q
G
-----
G
R
G
V
L
M
G
G
V
P
G
V
E
P
A
D
V
V
V
I
G
A
G
T
A
G
Y
N
A
A
R
I
A
N
G
M
G
A
T
V
T
V
L
------
D
I
N
I
D
K
L
R
QLDAEFCGRI
H
T
--------
R
Y
S
S
A
Y
E
-
L
E
G
-
A
V
K
R
A
D
L
V
---------
I
G
A
V
L
V
P
G
A
K
A
P
K
L
V
S
N
S
L
V
A
H
M
K
P
G
A
V
L
V
D
I
A
I
D
Q
G
G
C
F
E
G
S
R
P
T
T
Y
D
H
P
T
F
A
V
H
D
T
L
F
Y
C
V
A
N
M
P
A
S
V
P
K
T
S
T
Y
A
L
T
N
A
T
M
P
Y
V
L
E
L
A
D
H
G
W
R
A
A
C
R
S
N
P
A
L
A
K
----
G
L
S
T
H
E
G
A
L
L
S
E
R
V
A
T
D
L
G
V
P
F
T
E
P
A
S
V
L
A
--
3
PsiBlast_PDB
80.77
33%
-113
- C2 -
2VOJ
2
DHA_MYCTU
A:
[1-370]
M
R
V
G
I
P
T
E
T
K
N
N
E
F
R
V
A
I
T
P
A
G
V
A
E
L
T
R
R
G
H
E
V
L
I
Q
A
G
A
G
E
G
S
A
I
T
D
A
D
F
K
A
A
G
A
Q
L
V
G
T
A
D
Q
V
W
--
A
D
A
D
L
L
L
K
V
K
E
P
I
A
A
-
E
Y
G
R
L
R
H
G
Q
I
L
F
T
F
L
H
L
A
A
S
R
A
C
T
D
A
L
L
D
S
G
T
T
S
I
A
Y
E
T
V
Q
T
A
D
G
A
L
P
L
L
A
P
M
S
E
V
A
G
R
L
A
A
Q
V
G
A
Y
H
L
M
R
T
Q
G
-----
G
R
G
V
L
M
G
G
V
P
G
V
E
P
A
D
V
V
V
I
G
A
G
T
A
G
Y
N
A
A
R
I
A
N
G
M
G
A
T
V
T
V
L
------
D
I
N
I
D
K
L
R
Q
L
D
A
E
F
CGR
I
H
T
--------
R
Y
S
S
A
Y
E
-
L
E
G
-
A
V
K
R
A
D
L
V
---------
I
G
A
V
L
V
P
G
A
K
A
P
K
L
V
S
N
S
L
V
A
H
M
K
P
G
A
V
L
V
D
I
A
I
D
Q
G
G
C
F
E
G
S
R
P
T
T
Y
D
H
P
T
F
A
V
H
D
T
L
F
Y
C
V
A
N
M
P
A
S
V
P
K
T
S
T
Y
A
L
T
N
A
T
M
P
Y
V
L
E
L
A
D
H
G
W
R
A
A
C
R
S
N
P
A
L
A
K
----
G
L
S
T
H
E
G
A
L
L
S
E
R
V
A
T
D
L
G
V
P
F
T
E
P
A
S
V
L
A
--
28
PsiBlast_CBE
80.64
33%
-115
- C2 -
2VHW
1
DHA_MYCTU
D:
[1-370]
M
R
V
G
I
P
T
E
T
K
N
N
E
F
R
V
A
I
T
P
A
G
V
A
E
L
T
R
R
G
H
E
V
L
I
Q
A
G
A
G
E
G
S
A
I
T
D
A
D
F
K
A
A
G
A
Q
L
V
G
T
A
D
Q
V
W
--
A
D
A
D
L
L
L
K
V
K
E
P
I
A
A
-
E
Y
G
R
L
R
H
G
Q
I
L
F
T
F
L
H
L
A
A
S
R
A
C
T
D
A
L
L
D
S
G
T
T
S
I
A
Y
E
T
V
Q
T
A
D
G
A
L
P
L
L
A
P
M
S
E
V
A
G
R
L
A
A
Q
V
G
A
Y
H
L
M
R
T
Q
G
-----
G
R
G
V
L
M
G
G
V
P
G
V
E
P
A
D
V
V
V
I
G
A
G
T
A
G
Y
N
A
A
R
I
A
N
G
M
G
A
T
V
T
V
L
------
D
I
N
I
D
K
L
R
QLDAEFCGRI
H
T
--------
R
Y
S
S
A
Y
E
-
L
E
G
-
A
V
K
R
A
D
L
V
---------
I
G
A
V
L
V
P
G
A
K
A
P
K
L
V
S
N
S
L
V
A
H
M
K
P
G
A
V
L
V
D
I
A
I
D
Q
G
G
C
F
E
G
S
R
P
T
T
Y
D
H
P
T
F
A
V
H
D
T
L
F
Y
C
V
A
N
M
P
A
S
V
P
K
T
S
T
Y
A
L
T
N
A
T
M
P
Y
V
L
E
L
A
D
H
G
W
R
A
A
C
R
S
N
P
A
L
A
K
----
G
L
S
T
H
E
G
A
L
L
S
E
R
V
A
T
D
L
G
V
P
F
T
E
P
A
S
V
L
---
5
PsiBlast_PDB
80.64
33%
-115
- C2 -
2VHW
2
DHA_MYCTU
A:
[1-370]
M
R
V
G
I
P
T
E
T
K
N
N
E
F
R
V
A
I
T
P
A
G
V
A
E
L
T
R
R
G
H
E
V
L
I
Q
A
G
A
G
E
G
S
A
I
T
D
A
D
F
K
A
A
G
A
Q
L
V
G
T
A
D
Q
V
W
--
A
D
A
D
L
L
L
K
V
K
E
P
I
A
A
-
E
Y
G
R
L
R
H
G
Q
I
L
F
T
F
L
H
L
A
A
S
R
A
C
T
D
A
L
L
D
S
G
T
T
S
I
A
Y
E
T
V
Q
T
A
D
G
A
L
P
L
L
A
P
M
S
E
V
A
G
R
L
A
A
Q
V
G
A
Y
H
L
M
R
T
Q
G
-----
G
R
G
V
L
M
G
G
V
P
G
V
E
P
A
D
V
V
V
I
G
A
G
T
A
G
Y
N
A
A
R
I
A
N
G
M
G
A
T
V
T
V
L
------
D
I
N
I
D
K
L
R
Q
L
D
A
E
F
C
GR
I
H
T
--------
R
Y
S
S
A
Y
E
-
L
E
G
-
A
V
K
R
A
D
L
V
---------
I
G
A
V
L
V
P
G
A
K
A
P
K
L
V
S
N
S
L
V
A
H
M
K
P
G
A
V
L
V
D
I
A
I
D
Q
G
G
C
F
E
G
S
R
P
T
T
Y
D
H
P
T
F
A
V
H
D
T
L
F
Y
C
V
A
N
M
P
A
S
V
P
K
T
S
T
Y
A
L
T
N
A
T
M
P
Y
V
L
E
L
A
D
H
G
W
R
A
A
C
R
S
N
P
A
L
A
K
----
G
L
S
T
H
E
G
A
L
L
S
E
R
V
A
T
D
L
G
V
P
F
T
E
P
A
S
V
L
A
--
23
PsiBlast_CBE
80.49
33%
-112
- C2 -
2VHZ
1
DHA_MYCTU
B:
[1-370]
M
R
V
G
I
P
T
E
T
K
N
N
E
F
R
V
A
I
T
P
A
G
V
A
E
L
T
R
R
G
H
E
V
L
I
Q
A
G
A
G
E
G
S
A
I
T
D
A
D
F
K
A
A
G
A
Q
L
V
G
T
A
D
Q
V
W
--
A
D
A
D
L
L
L
K
V
K
E
P
I
A
A
-
E
Y
G
R
L
R
H
G
Q
I
L
F
T
F
L
H
L
A
A
S
R
A
C
T
D
A
L
L
D
S
G
T
T
S
I
A
Y
E
T
V
Q
T
A
D
G
A
L
P
L
L
A
P
M
S
E
V
A
G
R
L
A
A
Q
V
G
A
Y
H
L
M
R
T
Q
G
-----
G
R
G
V
L
M
G
G
V
P
G
V
E
P
A
D
V
V
V
I
G
A
G
T
A
G
Y
N
A
A
R
I
A
N
G
M
G
A
T
V
T
V
L
------
D
I
N
I
D
K
L
R
QLDAEFCGRI
H
T
--------
R
Y
S
S
A
Y
E
-
L
E
G
-
A
V
K
R
A
D
L
V
---------
I
G
A
V
L
V
P
G
A
K
A
P
K
L
V
S
N
S
L
V
A
H
M
K
P
G
A
V
L
V
D
I
A
I
D
Q
G
G
C
F
E
G
S
R
P
T
T
Y
D
H
P
T
F
A
V
H
D
T
L
F
Y
C
V
A
N
M
P
A
S
V
P
K
T
S
T
Y
A
L
T
N
A
T
M
P
Y
V
L
E
L
A
D
H
G
W
R
A
A
C
R
S
N
P
A
L
A
K
----
G
L
S
T
H
E
G
A
L
L
S
E
R
V
A
T
D
L
G
V
P
F
T
E
P
A
S
V
L
A
--
21
PsiBlast_CBE
80.47
33%
-112
- C2 -
2VOJ
2
DHA_MYCTU
E:
[1-370]
M
R
V
G
I
P
T
E
T
K
N
N
E
F
R
V
A
I
T
P
A
G
V
A
E
L
T
R
R
G
H
E
V
L
I
Q
A
G
A
G
E
G
S
A
I
T
D
A
D
F
K
A
A
G
A
Q
L
V
G
T
A
D
Q
V
W
--
A
D
A
D
L
L
L
K
V
K
E
P
I
A
A
-
E
Y
G
R
L
R
H
G
Q
I
L
F
T
F
L
H
L
A
A
S
R
A
C
T
D
A
L
L
D
S
G
T
T
S
I
A
Y
E
T
V
Q
T
A
D
G
A
L
P
L
L
A
P
M
S
E
V
A
G
R
L
A
A
Q
V
G
A
Y
H
L
M
R
T
Q
G
-----
G
R
G
V
L
M
G
G
V
P
G
V
E
P
A
D
V
V
V
I
G
A
G
T
A
G
Y
N
A
A
R
I
A
N
G
M
G
A
T
V
T
V
L
------
D
I
N
I
D
K
L
R
QLDAEFCGRI
H
T
--------
R
Y
S
S
A
Y
E
-
L
E
G
-
A
V
K
R
A
D
L
V
---------
I
G
A
V
L
V
P
G
A
K
A
P
K
L
V
S
N
S
L
V
A
H
M
K
P
G
A
V
L
V
D
I
A
I
D
Q
G
G
C
F
E
G
S
R
P
T
T
Y
D
H
P
T
F
A
V
H
D
T
L
F
Y
C
V
A
N
M
P
A
S
V
P
K
T
S
T
Y
A
L
T
N
A
T
M
P
Y
V
L
E
L
A
D
H
G
W
R
A
A
C
R
S
N
P
A
L
A
K
----
G
L
S
T
H
E
G
A
L
L
S
E
R
V
A
T
D
L
G
V
P
F
T
E
P
A
S
V
L
A
--
24
PsiBlast_CBE
80.40
33%
-110
- C2 -
2VHX
3
DHA_MYCTU
F:
[1-370]
M
R
V
G
I
P
T
E
T
K
N
N
E
F
R
V
A
I
T
P
A
G
V
A
E
L
T
R
R
G
H
E
V
L
I
Q
A
G
A
G
E
G
S
A
I
T
D
A
D
F
K
A
A
G
A
Q
L
V
G
T
A
D
Q
V
W
--
A
D
A
D
L
L
L
K
V
K
E
P
I
A
A
-
E
Y
G
R
L
R
H
G
Q
I
L
F
T
F
L
H
L
A
A
S
R
A
C
T
D
A
L
L
D
S
G
T
T
S
I
A
Y
E
T
V
Q
T
A
D
G
A
L
P
L
L
A
P
M
S
E
V
A
G
R
L
A
A
Q
V
G
A
Y
H
L
M
R
T
Q
G
-----
G
R
G
V
L
M
G
G
V
P
G
V
E
P
A
D
V
V
V
I
G
A
G
T
A
G
Y
N
A
A
R
I
A
N
G
M
G
A
T
V
T
V
L
------
D
I
N
I
D
K
L
R
QLDAEFCGRI
H
T
--------
R
Y
S
S
A
Y
E
-
L
E
G
-
A
V
K
R
A
D
L
V
---------
I
G
A
V
L
V
P
G
A
K
A
P
K
L
V
S
N
S
L
V
A
H
M
K
P
G
A
V
L
V
D
I
A
I
D
Q
G
G
C
F
E
G
S
R
P
T
T
Y
D
H
P
T
F
A
V
H
D
T
L
F
Y
C
V
A
N
M
P
A
S
V
P
K
T
S
T
Y
A
L
T
N
A
T
M
P
Y
V
L
E
L
A
D
H
G
W
R
A
A
C
R
S
N
P
A
L
A
K
----
G
L
S
T
H
E
G
A
L
L
S
E
R
V
A
T
D
L
G
V
P
F
T
E
P
A
S
V
L
A
H
H
27
PsiBlast_CBE
80.35
33%
-111
- C2 -
2VHW
1
DHA_MYCTU
E:
[1-370]
M
R
V
G
I
P
T
E
T
K
N
N
E
F
R
V
A
I
T
P
A
G
V
A
E
L
T
R
R
G
H
E
V
L
I
Q
A
G
A
G
E
G
S
A
I
T
D
A
D
F
K
A
A
G
A
Q
L
V
G
T
A
D
Q
V
W
--
A
D
A
D
L
L
L
K
V
K
E
P
I
A
A
-
E
Y
G
R
L
R
H
G
Q
I
L
F
T
F
L
H
L
A
A
S
R
A
C
T
D
A
L
L
D
S
G
T
T
S
I
A
Y
E
T
V
Q
T
A
D
G
A
L
P
L
L
A
P
M
S
E
V
A
G
R
L
A
A
Q
V
G
A
Y
H
L
M
R
T
Q
G
-----
G
R
G
V
L
M
G
G
V
P
G
V
E
P
A
D
V
V
V
I
G
A
G
T
A
G
Y
N
A
A
R
I
A
N
G
M
G
A
T
V
T
V
L
------
D
I
N
I
D
K
L
R
QLDAEFCGRI
H
T
--------
R
Y
S
S
A
Y
E
-
L
E
G
-
A
V
K
R
A
D
L
V
---------
I
G
A
V
L
V
P
G
A
K
A
P
K
L
V
S
N
S
L
V
A
H
M
K
P
G
A
V
L
V
D
I
A
I
D
Q
G
G
C
F
E
G
S
R
P
T
T
Y
D
H
P
T
F
A
V
H
D
T
L
F
Y
C
V
A
N
M
P
A
S
V
P
K
T
S
T
Y
A
L
T
N
A
T
M
P
Y
V
L
E
L
A
D
H
G
W
R
A
A
C
R
S
N
P
A
L
A
K
----
G
L
S
T
H
E
G
A
L
L
S
E
R
V
A
T
D
L
G
V
P
F
T
E
P
A
S
V
L
A
H
H
31
PsiBlast_CBE
80.24
33%
-114
- C2 -
2VHV
1
DHA_MYCTU
B:
[1-370]
M
R
V
G
I
P
T
E
T
K
N
N
E
F
R
V
A
I
T
P
A
G
V
A
E
L
T
R
R
G
H
E
V
L
I
Q
A
G
A
G
E
G
S
A
I
T
D
A
D
F
K
A
A
G
A
Q
L
V
G
T
A
D
Q
V
W
--
A
D
A
D
L
L
L
K
V
K
E
P
I
A
A
-
E
Y
G
R
L
R
H
G
Q
I
L
F
T
F
L
H
L
A
A
S
R
A
C
T
D
A
L
L
D
S
G
T
T
S
I
A
Y
E
T
V
Q
T
A
D
G
A
L
P
L
L
A
P
M
S
E
V
A
G
R
L
A
A
Q
V
G
A
Y
H
L
M
R
T
Q
G
-----
G
R
G
V
L
M
G
G
V
P
G
V
E
P
A
D
V
V
V
I
G
A
G
T
A
G
Y
N
A
A
R
I
A
N
G
M
G
A
T
V
T
V
L
------
D
I
N
I
D
K
L
R
QLDAEFCGRI
H
T
--------
R
Y
S
S
A
Y
E
-
L
E
G
-
A
V
K
R
A
D
L
V
---------
I
G
A
V
L
V
P
G
A
K
A
P
K
L
V
S
N
S
L
V
A
H
M
K
P
G
A
V
L
V
D
I
A
I
N
Q
G
G
C
F
E
G
S
R
P
T
T
Y
D
H
P
T
F
A
V
H
D
T
L
F
Y
C
V
A
N
M
P
A
S
V
P
K
T
S
T
Y
A
L
T
N
A
T
M
P
Y
V
L
E
L
A
D
H
G
W
R
A
A
C
R
S
N
P
A
L
A
K
----
G
L
S
T
H
E
G
A
L
L
S
E
R
V
A
T
D
L
G
V
P
F
T
E
P
A
S
V
L
A
--
26
PsiBlast_CBE
80.05
33%
-112
- C2 -
2VHW
1
DHA_MYCTU
F:
[1-370]
M
R
V
G
I
P
T
E
T
K
N
N
E
F
R
V
A
I
T
P
A
G
V
A
E
L
T
R
R
G
H
E
V
L
I
Q
A
G
A
G
E
G
S
A
I
T
D
A
D
F
K
A
A
G
A
Q
L
V
G
T
A
D
Q
V
W
--
A
D
A
D
L
L
L
K
V
K
E
P
I
A
A
-
E
Y
G
R
L
R
H
G
Q
I
L
F
T
F
L
H
L
A
A
S
R
A
C
T
D
A
L
L
D
S
G
T
T
S
I
A
Y
E
T
V
Q
T
A
D
G
A
L
P
L
L
A
P
M
S
E
V
A
G
R
L
A
A
Q
V
G
A
Y
H
L
M
R
T
Q
G
-----
G
R
G
V
L
M
G
G
V
P
G
V
E
P
A
D
V
V
V
I
G
A
G
T
A
G
Y
N
A
A
R
I
A
N
G
M
G
A
T
V
T
V
L
------
D
I
N
I
D
K
L
R
QLDAEFCGRI
H
T
--------
R
Y
S
S
A
Y
E
-
L
E
G
-
A
V
K
R
A
D
L
V
---------
I
G
A
V
L
V
P
G
A
K
A
P
K
L
V
S
N
S
L
V
A
H
M
K
P
G
A
V
L
V
D
I
A
I
D
Q
G
G
C
F
E
G
S
R
P
T
T
Y
D
H
P
T
F
A
V
H
D
T
L
F
Y
C
V
A
N
M
P
A
S
V
P
K
T
S
T
Y
A
L
T
N
A
T
M
P
Y
V
L
E
L
A
D
H
G
W
R
A
A
C
R
S
N
P
A
L
A
K
----
G
L
S
T
H
E
G
A
L
L
S
E
R
V
A
T
D
L
G
V
P
F
T
E
P
A
S
V
L
A
H
H
8
PsiBlast_PDB
80.03
33%
-112
- C2 -
2VHV
1
DHA_MYCTU
A:
[1-370]
M
R
V
G
I
P
T
E
T
K
N
N
E
F
R
V
A
I
T
P
A
G
V
A
E
L
T
R
R
G
H
E
V
L
I
Q
A
G
A
G
E
G
S
A
I
T
D
A
D
F
K
A
A
G
A
Q
L
V
G
T
A
D
Q
V
W
--
A
D
A
D
L
L
L
K
V
K
E
P
I
A
A
-
E
Y
G
R
L
R
H
G
Q
I
L
F
T
F
L
H
L
A
A
S
R
A
C
T
D
A
L
L
D
S
G
T
T
S
I
A
Y
E
T
V
Q
T
A
D
G
A
L
P
L
L
A
P
M
S
E
V
A
G
R
L
A
A
Q
V
G
A
Y
H
L
M
R
T
Q
G
-----
G
R
G
V
L
M
G
G
V
P
G
V
E
P
A
D
V
V
V
I
G
A
G
T
A
G
Y
N
A
A
R
I
A
N
G
M
G
A
T
V
T
V
L
------
D
I
N
I
D
K
L
R
Q
L
D
A
E
F
C
GR
I
H
T
--------
R
Y
S
S
A
Y
E
-
L
E
G
-
A
V
K
R
A
D
L
V
---------
I
G
A
V
L
V
P
G
A
K
A
P
K
L
V
S
N
S
L
V
A
H
M
K
P
G
A
V
L
V
D
I
A
I
N
Q
G
G
C
F
E
G
S
R
P
T
T
Y
D
H
P
T
F
A
V
H
D
T
L
F
Y
C
V
A
N
M
P
A
S
V
P
K
T
S
T
Y
A
L
T
N
A
T
M
P
Y
V
L
E
L
A
D
H
G
W
R
A
A
C
R
S
N
P
A
L
A
K
----
G
L
S
T
H
E
G
A
L
L
S
E
R
V
A
T
D
L
G
V
P
F
T
E
P
A
S
V
L
A
--
2
PsiBlast_PDB
79.81
33%
-115
- C2 -
2VOE
-
DHA_MYCTU
A:
[1-370]
M
R
V
G
I
P
T
E
T
K
N
N
E
F
R
V
A
I
T
P
A
G
V
A
E
L
T
R
R
G
H
E
V
L
I
Q
A
G
A
G
E
G
S
A
I
T
D
A
D
F
K
A
A
G
A
Q
L
V
G
T
A
D
Q
V
W
--
A
D
A
D
L
L
L
K
V
K
E
P
I
A
A
-
E
Y
G
R
L
R
H
G
Q
I
L
F
T
F
L
H
L
A
A
S
R
A
C
T
D
A
L
L
D
S
G
T
T
S
I
A
Y
E
T
V
Q
T
A
D
G
A
L
P
L
L
A
P
M
S
E
V
A
G
R
L
A
A
Q
V
G
A
Y
H
L
M
R
T
Q
G
-----
G
R
G
V
L
M
G
G
V
P
G
V
E
P
A
D
V
V
V
I
G
A
G
T
A
G
Y
N
A
A
R
I
A
N
G
M
G
A
T
V
T
V
L
------
D
I
N
I
D
K
L
R
Q
L
D
A
E
F
CGR
I
H
T
--------
R
Y
S
S
A
Y
E
-
L
E
G
-
A
V
K
R
A
D
L
V
---------
I
G
A
V
L
V
P
G
A
K
A
P
K
L
V
S
N
S
L
V
A
H
M
K
P
G
A
V
L
V
D
I
A
I
D
Q
G
G
C
F
E
G
S
R
P
T
T
Y
D
H
P
T
F
A
V
H
D
T
L
F
Y
C
V
A
N
M
P
A
S
V
P
K
T
S
T
Y
A
L
T
N
A
T
M
P
Y
V
L
E
L
A
D
H
G
W
R
A
A
C
R
S
N
P
A
L
A
K
----
G
L
S
T
H
E
G
A
L
L
S
E
R
V
A
T
D
L
G
V
P
F
T
E
P
A
S
V
L
A
--
105
Fugue
76.16
34%
-117
- C2 -
1PJC
1
?
A:
[1-361]
M
E
I
G
V
P
K
E
I
K
N
Q
E
F
R
V
G
L
S
P
S
S
V
R
T
L
V
E
A
G
H
T
V
F
I
E
T
Q
A
G
I
G
A
G
F
A
D
Q
D
Y
V
Q
A
G
A
Q
V
V
P
S
-
A
K
D
A
W
S-
R
-
E
M
V
V
K
V
K
E
P
L
P
-A
E
Y
D
L
M
Q
K
D
Q
L
L
F
T
Y
L
H
L
A
A
A
R
E
L
T
E
Q
L
M
R
V
G
L
T
A
I
A
Y
E
T
V
E
L
P
N
R
S
L
P
L
L
T
P
M
S
I
I
A
G
R
L
S
V
Q
F
G
A
R
F
L
E
R
Q
Q
G
G
R
G
V
L
L
G
G
V
P
-
G
----
V
K
P
G
K
V
V
I
L
G
G
G
V
V
G
T
E
A
A
K
M
A
V
G
L
G
A
Q
V
Q
I
F
D
IN
V
E
R
L
S
Y
L
E
T
L
F
----------
G
S
R
V
E
L
L
Y
SN---------------
S
A
E
I
E
T
A
V
A
E
A
D
L
L
I
G
A
V
L
V
P
G
R
R
A
P
I
L
V
P
A
S
L
V
E
Q
M
R
T
G
S
V
I
V
D
V
A
V
D
Q
G
G
C
V
E
T
L
H
P
T
S
H
T
Q
P
T
Y
E
V
F
G
V
V
H
Y
G
V
P
N
M
P
G
A
V
P
W
T
A
T
Q
A
L
N
N
S
T
L
P
Y
V
V
K
L
A
N
Q
G
L
-----
K
A
L
E
T
D
D
A
L
A
K
G
L
N
V
Q
A
H
R
L
V
H
P
A
V
Q
-
Q
V
F
P
D
L
A
---------