@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_1464: (2015-12-24 )
MDNKNIDPCFNPEQFLETQKYKGVVTALIFLLLFFIFLMVAFKKAFFAQANMPTLVMIKQDTATRGTIYSQDNYSLATSQTLFKLGFDTRFLNPNKEDFFIDFLSIYSNIPKESLKDALNTKGYTILAYNLTPNMAANIRDLNKKFLAFGVFQNFKDAHDKVWQKQGLNIEVSGVSRHYPYQNSLEPIIGYVQKQEEDKLTLTTGKKGVEKSQNNLLEAQQNGIRSGKRDVSFNFIQNHSYTEVERLDGYEVYLSVPLKLQREIETLLDKTKDKLRAKEILVGIINPKSGEILSLASSNRFDPNAIKTSDYENLNLSVAEKVFEPGSTIKPIVYSLLLDKNLINPKERIDLNHGYYQLGKYTIKDDFIPSKKAVVEDVLIQSSNVGMIKISKSLNPEDFYNGLLGYGFSQKTGIDLSLEATGKIPPLSAFKREVLKGSVSYGYGLNATFLQLLRAYAVFSNEGKLTTPYLVQRETAPNGDIYIPSPKPTFQVISPKSARKMKETLIKVVRYGTGKNAQFEGLYIGGKTGTARVAKNGSYSAESYNSSFFGFAEDERQVFTIGVVILGSHGKEEYYASKIAAPIFKEITEILVRYNYLSPSIAIQNALEKNRLK
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........---80........90..-.-.....100.......110.......---120-------------------------------------------------------------------.......----------------.130.......140-........150.......160.......170.......180.......190...-.-.-.--------------.200.......210.......220.......230......-.240........250.......260---......----..270....-------...280.......290.......300----.....-..310-------------.........320.......330.......340.......350.---......360.....------..----.-----.370.-----........380.......390..-----------.-----------------.-------.---..400.......410--........420.......430.......440..-...-------..450.......460.......470.......480---..-..-..----...-490-........500......-.510--------.-..----------..-.-.-..520.......530..--.--..--..--.540.........550-..--......560...--....570.......580.......590.......600.......610.-----------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MDNKNIDPCF
N
P
E
Q
F
L
E
T
Q
K
Y
K
G
V
V
T
A
L
I
F
L
L
L
F
F
I
F
L
M
V
A
F
K
K
A
F
F
AQANM
P
T
L
V
M
I
KQDTATRG
T
I
YSQDNYSLAT
S
---
Q
T
L
F
KLGFDTRFLN-P-N
K
E
D
F
F
I
D
F
L
S
I
YSNI
P
K
E
S
L
K
D
A
L---NT--------------------------------------------------------------------KG
Y
T
I
L
A
----------------YNLTPN
M
A
A
N
I
R
D
--
L
N
K
K
F
L
A
F
G
V
F
Q
N
F
K
D
A
H
D
K
V
W
Q
KQG
L
N
I
E
V
SGVSRHYPYQNS
L
E
P
I
I
G
Y
V
Q
KQ-E-E-D--------------
K
L
T
L
TTGKKGV
E
K
S
Q
N
N
L
L
E
A
Q
Q
N
G
I
RSGKRD
V
S
F
N
F
IQN-HS-YT
E
V
ERLDG
Y
E
V
Y
LSV
P
L
K
L
Q
----
R
E
I
E
T
L
----
L
D
K
T
K
D
K
L
R
-------
A
K
E
I
L
V
G
I
INPKSG
E
I
L
S
LASSNRFD----PNAIK-TSD---------------YENL
N
L
S
V
A
E
K
VFEPGS
T
I
K
P
I
V
Y
S
L
L
L
D
K
NLI
N
P
K
E
R
I
DLNH---G
Y
Y
Q
LG
K
--
Y
T
I
KD------DF----I-----P
S
--
K
-----
K
A
V
V
E
D
V
L
IQSSNV
G
M
I
K
I
SKSL-----------
N
-----------------
P
-------
E
---
D
F
Y
N
G
L
L
GYGFSQK---TG
I
D
L
S
L
EATGKIP
P
L
S
A
F
K
R
E
V
L
KGSVSYGYG-L
N
A
-------
T
F
L
Q
L
L
R
A
Y
A
V
FSNEGKLTT
P
Y
L
V
Q
RETAPNG
D
-----
I
Y
-IP-SP----KP
T
-
F
-
Q
-
V
IS
P
K
S
A
R
K
M
K
E
T
L
I
K
V
-
V
R----------Y-GT----------GK-N-
A
-
Q
F
E
G
L
Y
IGGKTG
T
A
-
R
V
--A--KN--GS--YS--AESYNSSFFGF--AE--DE
R
Q
V
F
T
I
G
V
V
I
--LGSHG
K
E
E
Y
Y
A
S
K
I
A
A
P
I
F
K
E
I
T
E
I
L
V
R
YNYLS
P
S
I
A
I
Q
N
A
L
E
KNRLK-----------------------------------------------------------------------------------------------------------------
56
Fugue
88.86
28%
-57
- C1 -
3OC2
3
?
A:
[35-545]
----------------------------------------------------
A
R
S
V
R
H
I
A
I
P
A
H
R
G
L
I
T
D
R
N
G
E
P
L
A
V
S
---
T
P
V
T
T
L
W
A
N
P
K
E
L
M
-
T
-
A
K
E
R
W
--
P
Q
L
A
A
A
L
G
Q
D
T
K
L
F
A
D
R
I
E
Q
N
A
E
--------------------------------------------------------------------
R
E
F
I
Y
L
V
----------------
R
G
L
T
P
E
Q
G
E
G
V
I
A
--
L
K
V
P
---------------------
G
V
Y
S
I
E
E
-
F
R
R
F
Y
P
A
G
E
V
V
A
H
A
V
G
F
T
D
V
D
-
D
-
R
----------------------
G
R
E
G
I
E
L
A
F
D
E
W
L
A
-
G
V
P
G
K
R
Q
V
L
K
D
R
R
G
R
V
I
K
D
-
V
Q
-
V
T
K
N
A
K
-
P
G
K
T
L
A
L
S
I
D
L
R
L
Q
----
Y
L
A
H
R
E
----
L
R
N
A
L
L
E
N
G
-------
A
K
A
G
S
L
V
I
M
D
V
K
T
G
E
I
L
A
M
T
N
Q
P
T
Y
N
----
P
N
N
R
R
-
N
L
Q
---------------
P
A
A
M
R
N
R
A
M
I
D
V
F
E
P
G
S
T
V
K
P
F
S
M
S
A
A
L
A
S
G
R
W
K
P
S
D
I
V
D
V
Y
P
---
G
T
L
Q
I
G
R
--
Y
T
I
R
D
------
V
S
----
R
-----
N
S
--
R
-----
Q
L
D
L
T
G
I
L
I
K
S
S
N
V
G
I
S
K
I
A
F
D
I
-----------
G
-----------------
A
-------
E
---
S
I
Y
S
V
M
Q
Q
V
G
L
G
Q
D
---
T
G
L
G
F
P
G
E
R
V
G
N
L
P
N
H
R
K
W
-
P
K
A
E
T
A
T
L
A
Y
G
Y
G
-
L
S
V
-------
T
A
I
Q
L
A
H
A
Y
A
A
L
A
N
D
G
K
S
V
P
L
S
M
T
R
V
D
R
V
P
D
G
----------------------
V
-
Q
-
V
I
S
P
E
V
A
S
T
V
Q
G
M
L
Q
Q
V
-
V
E
----------
A
Q
G
G
----------
V
F
-
R
-
A
-
Q
V
P
G
Y
H
A
A
G
K
S
G
T
A
-
R
-------------------
K
A
Y
R
S
L
F
A
G
F
--
A
P
--
A
T
D
P
R
I
A
M
V
V
V
I
--
D
E
P
------
F
G
G
L
V
S
A
P
V
F
S
K
V
M
A
G
A
L
R
L
M
N
V
P
P
D
N
L
----------------------------------------------------------------------------------------------------------------------------
58
Fugue
86.77
23%
-46
- C1 -
1QME
3
PBPX_STRPN
A:
[23-702]
--------------------------------------
T
V
P
A
K
R
G
T
I
Y
D
R
N
G
V
P
I
A
E
D
A
T
---------
S
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
R
S
Y
P
N
G
Q
F
A
S
S
F
I
G
L
A
Q
L
H
E
N
-
E
-
D
--------------
G
S
K
S
L
L
G
T
S
G
M
E
S
S
L
N
S
I
L
A
G
T
D
G
------------------------
R
T
M
D
G
K
D
V
Y
T
T
I
S
S
P
L
Q
----
S
F
M
E
T
Q
----
M
D
A
F
Q
E
K
V
K
-------
G
K
Y
M
T
A
T
L
V
S
A
K
T
G
E
I
L
A
T
T
Q
R
P
T
F
D
----
A
D
T
K
E
G
I
T
E
---------------
D
F
V
W
R
D
I
L
Y
Q
S
N
Y
E
P
G
S
T
M
K
V
M
M
L
A
A
A
I
D
N
N
T
F
P
G
G
E
--
V
F
N
S
---
S
E
L
K
I
A
D
--
A
T
I
R
D
------
W
D
----
V
-----
N
E
--
G
LTG
G
R
M
M
T
F
S
Q
G
F
A
H
S
S
N
V
G
M
T
L
L
E
Q
K
M
-----------
G
-----------------
D
-------
A
---
T
W
L
D
Y
L
N
R
F
K
F
G
V
P
---
T
R
F
G
L
T
D
E
Y
A
G
Q
L
P
A
----
D
N
I
V
N
I
A
Q
S
S
F
G
Q
G
-
I
S
V
-------
T
Q
T
Q
M
I
R
A
F
T
A
I
A
N
D
G
V
M
L
E
P
K
F
I
S
A
I
Y
D
P
N
D
Q
-----
T
A
-
R
K
-
S
Q
----
K
E
I
-
V
G
N
-
P
V
S
K
D
A
A
S
L
T
R
T
N
M
V
L
V
-
G
T
----------
D
-
P
V
YGTMYNHSTG
K
P
-
T
-
V
-
T
V
P
G
Q
N
V
A
L
K
S
G
T
A
-
Q
I
AD
E
--
K
N
--
G
G
--
Y
L
VG
L
T
D
Y
I
F
S
A
V
S
M
--
S
P
--
A
E
N
P
D
F
I
L
Y
V
T
V
--
Q
Q
P
E
H
Y
S
G
I
Q
L
G
E
F
A
N
P
I
L
E
R
A
S
A
M
K
D
S
L
N
-----------
L
Q
Q
S
P
Y
P
MPSVKDIS
P
G
D
L
A
E
E
L
R
R
N
L
V
Q
P
I
V
V
G
TGTKIKNSSAEEGKNLAPN
Q
Q
V
L
I
L
S
DKAEEVPDMYGWT
K
E
T
A
E
T
L
A
K
W
L
N
I
E
L
E
F
Q
G
SGSTVQKQDVRANTAIKDIK
K
I
T
L
T
L
G
D
33
HHSearch
85.06
25%
-50
* C1 *
3EQU
11
PBP2_NEIGO
A:
[24-534]
---------------------------------------------------
N
R
I
V
R
-
T
Q
A
L
P
A
T
R
G
T
V
S
D
R
N
G
A
V
L
A
L
S
---
A
P
T
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
R
H
Y
P
M
G
N
L
F
A
H
V
I
G
F
T
D
I
----
D
-
G
-------------------
K
G
Q
E
G
L
E
L
S
L
E
D
S
L
Y
G
-
E
D
G
A
E
V
V
L
R
D
R
Q
G
N
I
V
D
S
-
L
D
S
P
R
N
K
A
P
Q
N
G
K
D
I
I
L
S
L
D
Q
R
I
Q
----
T
L
A
Y
E
E
----
L
N
K
A
V
E
Y
H
Q
-------
A
K
A
G
T
V
V
V
L
D
A
R
T
G
E
I
L
A
L
A
N
T
P
A
Y
D
----
P
N
R
P
G
-
R
A
D
---------------
S
E
Q
R
R
N
R
A
V
T
D
M
I
E
P
G
S
A
I
K
P
F
V
I
A
K
A
L
D
A
G
K
T
D
L
N
E
R
L
N
T
Q
-----
P
Y
K
I
G
P
--
S
P
V
R
D
------
T
-----
H
-----
V
Y
--
P
-----
S
L
D
V
R
G
I
M
Q
K
S
S
N
V
G
T
S
K
L
S
A
R
F
-----------
G
-----------------
A
-------
E
---
E
M
Y
D
F
Y
H
E
L
G
I
G
V
R
---
M
H
S
G
F
P
G
E
T
A
G
L
L
R
N
W
R
R
W
-
R
P
I
E
Q
A
T
M
S
F
G
Y
G
-
L
Q
L
-------
S
L
L
Q
L
A
R
A
Y
T
A
L
T
H
D
G
V
L
L
P
L
S
F
E
K
Q
A
V
A
P
Q
G
----------------------
K
-
R
-
I
F
K
E
S
T
A
R
E
V
R
N
L
M
V
S
V
-
T
E
P---------
G
-
G
T
----------
G
T
-
A
-
G
-
A
V
D
G
F
D
V
G
A
K
T
G
T
A
----------------------
K
H
V
A
T
F
I
G
F
--
A
P
--
A
K
N
P
R
V
I
V
A
V
T
I
--
D
E
P
T
A
-
H
G
Y
Y
G
G
V
V
A
G
P
P
F
K
K
I
M
G
G
S
L
N
I
L
G
I
S
P
T
K
P
L
T
--------------------------------------------------------------------------------------------------------------------------
59
Fugue
84.51
22%
-42
- C1 -
1QME
3
PBPX_STRPN
A:
[23-702]
-----------------------------------------------------------------------------------------------------------------
T
V
P
A
K
R
G
T
-
I
Y
---
D
R
--------------------------------------------------------------------
N
G
V
P
I
A
E
----------------
D
A
T
S
P
--------------------------------------------
N
R
S
Y
P
N
G
Q
F
A
S
S
F
I
G
L
A
Q
L
H
E
N
-
E
-
D
--------------
G
S
K
S
L
L
G
T
S
G
M
E
S
S
L
N
S
I
L
A
G
T
D
G
R
T
M
D
G
K
------------------------
D
V
Y
T
T
I
S
S
P
L
Q
----
S
F
M
E
T
Q
----
M
D
A
F
Q
E
K
V
K
-------
G
K
Y
M
T
A
T
L
V
S
A
K
T
G
E
I
L
A
T
T
Q
R
P
T
F
D
----
A
D
T
K
E
G
I
T
E
---------------
D
F
V
W
R
D
I
L
Y
Q
S
N
Y
E
P
G
S
T
M
K
V
M
M
L
A
A
A
I
D
N
N
T
F
P
G
G
E
V
F
N
--
S
---
S
E
L
K
I
A
D
--
A
T
I
R
D
------
W
D
----
V
-----
N
E
--
G
LTG
G
R
M
M
T
F
S
Q
G
F
A
H
S
S
N
V
G
M
T
L
L
E
Q
K
M
-----------
G
-----------------
D
-------
A
---
T
W
L
D
Y
L
N
R
F
K
F
G
V
P
---
T
R
F
G
L
T
D
E
Y
A
G
Q
L
P
A
----
D
N
I
V
N
I
A
Q
S
S
F
G
Q
G
-
I
S
V
-------
T
Q
T
Q
M
I
R
A
F
T
A
I
A
N
D
G
V
M
L
E
P
K
F
I
S
A
I
Y
D
P
N
D
Q
-----
T
A
-
R
K
-
S
Q
----
K
E
I
-
V
G
N
-
P
V
S
K
D
A
A
S
L
T
R
T
N
M
V
L
V
-
G
T
DPVYGTMYNH
S
-
T
G
----------
K
P
-
T
-
V
-
T
V
P
G
Q
N
V
A
L
K
S
G
T
A
-
Q
I
AD
E
--
K
N
--
G
G
--
Y
L
VG
L
T
D
Y
I
F
S
A
V
S
M
--
S
P
--
A
E
N
P
D
F
I
L
Y
V
T
V
--
Q
Q
P
E
H
Y
S
G
I
Q
L
G
E
F
A
N
P
I
L
E
R
A
S
A
M
K
D
S
L
N
L
Q
Q
S
P
Y
P
M
P
S
V
K
D
I
S
P
G
D
L
A
E
E
L
R
R
N
L
V
Q
P
I
V
V
G
TGTKIKNSSAEEGKNLAPN
Q
Q
V
L
I
L
S
DKAEEVPDMYGWT
K
E
T
A
E
T
L
A
K
W
L
N
I
E
L
E
F
Q
G
SGSTVQKQDVRANTAIKDIK
K
I
T
L
T
L
G
D-----------
36
HHSearch
83.09
22%
-49
- C1 -
1QME
3
PBPX_STRPN
A:
[23-566]
-----------------------------------------------------------
T
V
P
A
K
R
G
T
I
Y
D
R
N
G
V
P
I
A
E
D
---
A
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
N
R
S
Y
P
N
G
Q
F
A
S
S
F
I
G
L
A
Q
L
H
-
E
-
N
-
E
D-------------
G
S
K
S
L
L
G
T
S
G
M
E
S
S
L
N
S
I
L
A
G
-
T
D
G
-----------------------
R
T
M
D
G
K
D
V
Y
T
T
I
S
S
P
L
Q
----
S
F
M
E
T
Q
----
M
D
A
F
Q
E
K
V
K
-------
G
K
Y
M
T
A
T
L
V
S
A
K
T
G
E
I
L
A
T
T
Q
R
P
T
F
D
----
A
D
T
K
E
-
G
I
T
E--------------
D
F
V
W
R
D
I
L
Y
Q
S
N
Y
E
P
G
S
T
M
K
V
M
M
L
A
A
A
I
D
N
N
T
F
P
G
G
E
V
F
N
S
-----
S
E
L
K
I
A
D
--
A
T
I
R
D
------
W
D
----
V
N
E
GLT
G
G
--
R
-----
M
M
T
F
S
Q
G
F
A
H
S
S
N
V
G
M
T
L
L
E
Q
K
M
-----------
G
-----------------
D
-------
A
---
T
W
L
D
Y
L
N
R
F
K
F
G
V
P
---
T
R
F
G
L
T
D
E
Y
A
G
Q
L
P
A
D
----
N
I
V
N
I
A
Q
S
S
F
G
Q
G
-
I
S
V
-------
T
Q
T
Q
M
I
R
A
F
T
A
I
A
N
D
G
V
M
L
E
P
K
F
I
S
A
I
Y
D
P
N
D
Q
-----
T
A
-
R
K
S
Q
K
----
E
I
V
-
G
-
N
-
P
V
S
K
D
A
A
S
L
T
R
T
N
M
V
L
V
-
G
T
DPV-------
Y
-
G
T
MYNHST----
G
K
-
P
T
V
-
T
V
P
G
Q
N
V
A
L
K
S
G
T
A
-
Q
I
--
A
--
D
E
KN
G
G
--
Y
L
VG
L
T
D
Y
I
F
S
A
V
S
M
--
S
P
--
A
E
N
P
D
F
I
L
Y
V
T
V
--
Q
Q
P
E
H
----
Y
S
G
I
Q
L
G
E
F
A
N
P
I
L
E
R
A
S
A
M
K
D
S
L
N
L
Q
Q
S
P
Y
P
M
P
S
V
K
D
I
-----------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
83.02
27%
-46
- C1 -
3EQU
11
PBP2_NEIGO
A:
[26-517]
------------------------------------------------------
I
V
R
T
Q
A
L
P
A
T
R
G
T
V
S
D
R
N
G
A
V
L
A
L
S
A
P
T
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
R
H
Y
P
M
G
N
L
F
A
H
V
I
G
F
T
D
I
D
-
G
-
K
----------------------
G
Q
E
G
L
E
L
S
L
E
D
S
L
Y
G
E
-
D
G
A
E
V
V
L
R
D
R
Q
G
N
I
V
D
S
L
D
S
-
P
R
N
K
A
P
Q
N
G
K
D
I
I
L
S
L
D
Q
R
I
Q
----
T
L
A
Y
E
E
----
L
N
K
A
V
E
Y
H
Q
-------
A
K
A
G
T
V
V
V
L
D
A
R
T
G
E
I
L
A
L
A
N
T
P
A
Y
D
----
P
N
R
P
G
-
R
A
D
---------------
S
E
Q
R
R
N
R
A
V
T
D
M
I
E
P
G
S
A
I
K
P
F
V
I
A
K
A
L
D
A
G
K
T
D
L
N
E
R
--
L
N
T
---
Q
P
Y
K
I
G
P
--
S
P
V
R
D
------
T
H
----
V
Y----
P
S
--
L
-----
D
--
V
R
G
I
M
Q
K
S
S
N
V
G
T
S
K
L
S
A
R
F
-----------
G
-----------------
A
-------
E
E
M
Y
D
F
Y
H
-
E
L
G
I
G
V
R
M
H
---
S
G
--
F
P
G
E
T
A
G
L
L
R
N
W
R
R
W
-
R
P
I
E
Q
A
T
M
S
F
G
Y
G
-
L
Q
L
-------
S
L
L
Q
L
A
R
A
Y
T
A
L
T
H
D
G
V
L
L
P
L
S
F
E
K
Q
A
V
A
P
Q
G
K
-----------------------
R
-
I
F
K
E
S
T
A
R
E
V
R
N
L
M
V
S
V
-
T
E
P---------
G
-
G
T
----------
G
T
-
A
-
G
-
A
V
D
G
F
D
V
G
A
K
T
G
T
A
----------------------
K
H
V
A
T
F
I
G
F
AP
A
K
--
N
P
R
V
I
V
A
V
T
I
D
E
--
P
T
A
H
G
---
Y
Y
G
G
V
V
A
G
P
P
F
K
K
I
M
G
G
S
L
N
I
L
G
I
S
P
T
K
P
L
T
--------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
80.13
26%
-69
- C1 -
4BJP
26
?
A:
[101-499]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
Y
Y
P
S
G
E
V
T
A
H
L
I
G
F
T
N
V
D
-
S
-
Q
----------------------
G
I
E
G
V
E
K
S
F
D
K
W
L
T
--------------------------------
A
H
N
L
A
L
S
I
D
E
R
L
Q
----
A
L
V
Y
R
E
----
L
N
N
A
V
A
F
N
K
-------
A
E
S
G
S
A
V
L
V
D
V
N
T
G
E
V
L
A
M
A
N
S
P
S
Y
N
----
P
N
N
L
S
-
G
T
P
---------------
K
E
A
M
R
N
R
T
I
T
D
V
F
E
P
G
S
T
V
K
P
M
V
V
M
T
A
L
Q
R
G
V
V
--
R
E
N
S
V
L
N
T
---
I
P
Y
R
I
N
G
--
H
E
I
K
-------
D
V
----
A
-----
R
Y
--
S
-----
E
L
T
L
T
G
V
L
Q
K
S
S
N
V
G
V
S
K
L
A
L
A
M
-----------
P
-----------------
S
-------
S
---
A
L
V
D
T
Y
S
R
F
G
L
G
K
A
---
T
N
L
G
L
V
G
E
R
S
G
L
Y
P
Q
K
Q
R
W
S
-
D
I
E
R
A
T
F
S
F
G
Y
G
-
L
M
V
-------
T
P
L
Q
L
A
R
V
Y
A
T
I
G
S
Y
G
-
I
Y
R
P
L
S
I
T
K
---------------
V
D
-
P
P
----
V
P
G
-
E
-
R
-
V
F
P
E
S
I
V
R
T
V
V
H
M
M
E
S
V
A
L
P
----------
G
-
G
G
----------
G
V
-
K
-
A
-
A
I
K
G
Y
R
I
A
I
K
T
G
T
A
K
K
V
--
G
--
P
D
--
G
R
--
Y
---
I
N
K
Y
I
A
Y
T
A
G
V
--
A
P
--
A
S
Q
P
R
F
A
L
-
V
V
V
--
I
N
D
P
Q
A
-------
V
S
A
P
V
F
G
A
I
M
G
G
V
L
R
T
M
N
I
E
P
D
A
-----------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
78.87
28%
-54
- C1 -
4KQR
11
?
A:
[138-542]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
Y
P
A
G
E
V
V
A
H
A
V
G
F
T
D
V
D
-
D
-
R
----------------------
G
R
E
G
I
E
L
A
F
D
E
W
L
-
A
G
V
P
G
K
R
Q
V
L
K
D
R
R
G
R
V
I
K
D
-
V
Q
-
V
T
K
N
A
K
-
P
G
K
T
L
A
L
S
I
D
L
R
L
Q
Y
L
A
H
R
E
L
R
N
A
----
L
--
L
E
N
G
A
K
-------
A
G
S
L
V
--
I
M
D
V
K
T
G
E
I
L
A
M
T
N
Q
P
T
Y
N
----
P
N
N
R
R
-
N
L
Q
---------------
P
A
A
M
R
N
R
A
M
I
D
V
F
E
P
G
S
T
V
K
P
F
S
M
S
A
A
L
A
S
G
R
W
K
P
S
D
I
V
D
V
Y
P
---
G
T
L
Q
I
G
R
--
Y
T
I
R
D
------
V
S
----
R
-----
N
S
--
R
-----
Q
L
D
L
T
G
I
L
I
K
S
S
N
V
G
I
S
K
I
A
F
D
I
-----------
G
-----------------
A
-------
E
---
S
I
Y
S
V
M
Q
Q
V
G
L
G
Q
D
---
T
G
L
G
F
P
G
E
R
V
G
N
L
P
N
H
R
K
W
P
K
-
A
E
T
A
T
L
A
Y
G
Y
G
-
L
S
V
-------
T
A
I
Q
L
A
H
A
Y
A
A
L
A
N
D
G
K
S
V
P
L
S
M
T
R
V
D
R
V
P
D
G
----------------------
V
-
Q
-
V
I
S
P
E
V
A
S
T
V
Q
G
M
L
Q
Q
V
-
V
E
----------
A
-
Q
G
----------
G
V
F
R
-
A
-
Q
V
P
G
Y
H
A
A
G
K
S
G
T
A
-
R
K
--
V
--
S
V
--
G
T
KG
Y
R
--
E
N
A
Y
R
S
L
F
A
G
F
--
A
P
AT
D
P
R
I
A
M
---
V
V
V
--
I
D
E
P
S
K
A
G
Y
F
G
G
L
V
S
A
P
V
F
S
K
V
M
A
G
A
L
R
L
M
N
V
P
P
D
N
L
P
T
A
T
E
Q
Q
Q
V
N
------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
78.31
28%
-54
- C1 -
4KQO
3
?
A:
[138-542]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
Y
P
A
G
E
V
V
A
H
A
V
G
F
T
D
V
D
-
D
-
R
----------------------
G
R
E
G
I
E
L
A
F
D
E
W
L
-
A
G
V
P
G
K
R
Q
V
L
K
D
R
R
G
R
V
I
K
D
-
V
Q
-
V
T
K
N
A
K
-
P
G
K
T
L
A
L
S
I
D
L
R
L
Q
Y
L
A
H
R
E
L
R
N
A
----
L
--
L
E
N
G
A
K
-------
A
G
S
L
V
--
I
M
D
V
K
T
G
E
I
L
A
M
T
N
Q
P
T
Y
N
----
P
N
N
R
R
-
N
L
Q
---------------
P
A
A
M
R
N
R
A
M
I
D
V
F
E
P
G
S
T
V
K
P
F
S
M
S
A
A
L
A
S
G
R
W
K
P
S
D
I
V
D
V
Y
P
---
G
T
L
Q
I
G
R
--
Y
T
I
R
D
------
V
S
----
R
-----
N
S
--
R
-----
Q
L
D
L
T
G
I
L
I
K
S
S
N
V
G
I
S
K
I
A
F
D
I
-----------
G
-----------------
A
-------
E
---
S
I
Y
S
V
M
Q
Q
V
G
L
G
Q
D
---
T
G
L
G
F
P
G
E
R
V
G
N
L
P
N
H
R
K
W
P
K
-
A
E
T
A
T
L
A
Y
G
Y
G
-
L
S
V
-------
T
A
I
Q
L
A
H
A
Y
A
A
L
A
N
D
G
K
S
V
P
L
S
M
T
R
V
D
R
V
P
D
G
----------------------
V
-
Q
-
V
I
S
P
E
V
A
S
T
V
Q
G
M
L
Q
Q
V
-
V
E
----------
A
-
Q
G
----------
G
V
F
R
-
A
-
Q
V
P
G
Y
H
A
A
G
K
S
G
T
A
-
R
K
--
V
--
S
V
--
G
T
KG
Y
R
--
E
N
A
Y
R
S
L
F
A
G
F
--
A
P
AT
D
P
R
I
A
M
---
V
V
V
--
I
D
E
P
S
K
A
G
Y
F
G
G
L
V
S
A
P
V
F
S
K
V
M
A
G
A
L
R
L
M
N
V
P
P
D
N
L
P
T
--------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
77.96
28%
-55
- C1 -
4KQQ
5
?
A:
[138-542]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
Y
P
A
G
E
V
V
A
H
A
V
G
F
T
D
V
D
-
D
-
R
----------------------
G
R
E
G
I
E
L
A
F
D
E
W
L
-
A
G
V
P
G
K
R
Q
V
L
K
D
R
R
G
R
V
I
K
D
-
V
Q
-
V
T
K
N
A
K
-
P
G
K
T
L
A
L
S
I
D
L
R
L
Q
Y
L
A
H
R
E
L
R
N
A
----
L
--
L
E
N
G
A
K
-------
A
G
S
L
V
--
I
M
D
V
K
T
G
E
I
L
A
M
T
N
Q
P
T
Y
N
----
P
N
N
R
R
-
N
L
Q
---------------
P
A
A
M
R
N
R
A
M
I
D
V
F
E
P
G
S
T
V
K
P
F
S
M
S
A
A
L
A
S
G
R
W
K
P
S
D
I
V
D
V
Y
P
---
G
T
L
Q
I
G
R
--
Y
T
I
R
D
------
V
S
----
R
-----
N
S
--
R
-----
Q
L
D
L
T
G
I
L
I
K
S
S
N
V
G
I
S
K
I
A
F
D
I
-----------
G
-----------------
A
-------
E
---
S
I
Y
S
V
M
Q
Q
V
G
L
G
Q
D
---
T
G
L
G
F
P
G
E
R
V
G
N
L
P
N
H
R
K
W
P
K
-
A
E
T
A
T
L
A
Y
G
Y
G
-
L
S
V
-------
T
A
I
Q
L
A
H
A
Y
A
A
L
A
N
D
G
K
S
V
P
L
S
M
T
R
V
D
R
V
P
D
G
----------------------
V
-
Q
-
V
I
S
P
E
V
A
S
T
V
Q
G
M
L
Q
Q
V
-
V
E
----------
A
-
Q
G
----------
G
V
F
R
-
A
-
Q
V
P
G
Y
H
A
A
G
K
S
G
T
A
-
R
K
--
V
--
S
V
--
G
T
KG
Y
R
--
E
N
A
Y
R
S
L
F
A
G
F
--
A
P
AT
D
P
R
I
A
M
---
V
V
V
--
I
D
E
P
S
K
A
G
Y
F
G
G
L
V
S
A
P
V
F
S
K
V
M
A
G
A
L
R
L
M
N
V
P
P
D
N
L
P
T
A
T
E
Q
Q
Q
V
N
------------------------------------------------------------------------------------------------------------------
61
Fugue
77.69
22%
-43
- C1 -
1K25
-
?
A:
[67-750]
----------------------------------
Q
I
T
R
T
V
P
A
K
R
G
T
I
Y
D
R
N
G
V
P
I
A
E
D
A
T
S
Y
N
V
Y
A
V
T
T
S
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
R
S
Y
P
N
G
Q
F
A
S
S
F
I
G
L
A
Q
L
H
-
E
N
E
-
D
--------------
G
S
K
S
L
L
G
T
S
G
M
E
S
S
L
N
S
I
L
A
G
T
D
G
I
I
T
Y
G
N
I
------
V
P
G
-
T
E
-
L
V
S
Q
Q
T
V
D
G
K
D
V
Y
T
T
L
S
S
P
L
Q
----
S
F
M
E
T
Q
----
M
D
A
F
L
E
K
V
K
-------
G
K
Y
M
T
A
T
L
V
S
A
K
T
G
E
I
L
A
T
T
Q
R
P
T
F
N
----
A
D
T
K
E
G
I
T
E
---------------
D
F
V
W
R
D
I
L
Y
Q
S
N
Y
E
P
G
S
A
M
K
V
M
T
L
A
S
S
I
D
N
N
T
F
P
S
G
E
Y
F
N
S
S
E
------------------------------------------------------
L
S
S
N
V
G
M
S
L
L
E
Q
K
M
-----------
G
-----------------
D
-------
A
---
T
W
L
D
Y
L
K
R
F
K
F
G
V
P
---
T
R
F
G
L
T
D
E
Y
A
G
Q
L
P
A
----
D
N
I
V
S
I
A
Q
S
S
F
G
Q
G
-
I
S
V
-------
T
Q
T
Q
M
L
R
A
F
T
A
I
A
N
D
G
V
M
L
E
P
K
F
I
S
A
I
Y
D
T
N
N
Q
-----
S
V
-
R
K
-
S
Q
----
K
E
I
-
V
G
N
-
P
V
S
K
E
A
A
S
T
T
R
N
H
M
I
L
V
-
G
-------------
T
D
----------
P
L
-
I
-
I
-
T
V
P
G
Q
N
V
A
V
K
S
G
T
A
-
Q
I
--
A
DE
K
N
--
G
G
--
Y
L
VG
S
T
N
Y
I
F
S
A
V
T
M
--
N
P
--
A
E
N
P
D
F
I
L
Y
V
T
V
--
Q
Q
P
E
H
Y
S
G
I
Q
L
G
E
F
A
T
P
I
L
E
R
A
S
A
M
K
E
S
L
N
L
Q
S
P
A
K
N
L
D
K
V
T
T
E
S
S
Y
A
M
P
SIKDIS
P
G
E
L
A
E
A
L
R
R
N
I
V
Q
P
I
V
V
G
TGTKIKETSVEEGTNLAPN
Q
Q
V
L
L
L
S
DKVEEIPDMYGWK
K
E
T
A
E
T
F
A
K
W
L
D
I
E
L
E
F
E
G
SGSVVQKQDVRTNTAIKNIK
K
I
K
L
T
L
G
D
1
PsiBlast_PDB
77.18
28%
-55
- C1 -
3OCN
1
?
A:
[138-542]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
Y
P
A
G
E
V
V
A
H
A
V
G
F
T
D
V
D
-
D
-
R
----------------------
G
R
E
G
I
E
L
A
F
D
E
W
L
-
A
G
V
P
G
K
R
Q
V
L
K
D
R
R
G
R
V
I
K
D
-
V
Q
-
V
T
K
N
A
K
-
P
G
K
T
L
A
L
S
I
D
L
R
L
Q
Y
L
A
H
R
E
L
R
N
A
----
L
--
L
E
N
G
A
K
-------
A
G
S
L
V
--
I
M
D
V
K
T
G
E
I
L
A
M
T
N
Q
P
T
Y
N
----
P
N
N
R
R
-
N
L
Q
---------------
P
A
A
M
R
N
R
A
M
I
D
V
F
E
P
G
S
T
V
K
P
F
S
M
S
A
A
L
A
S
G
R
W
K
P
S
D
I
V
D
V
Y
P
---
G
T
L
Q
I
G
R
--
Y
T
I
R
D
------
V
S
----
R
-----
N
S
--
R
-----
Q
L
D
L
T
G
I
L
I
K
S
S
N
V
G
I
S
K
I
A
F
D
I
-----------
G
-----------------
A
-------
E
---
S
I
Y
S
V
M
Q
Q
V
G
L
G
Q
D
---
T
G
L
G
F
P
G
E
R
V
G
N
L
P
N
H
R
K
W
P
K
-
A
E
T
A
T
L
A
Y
G
Y
G
-
L
S
V
-------
T
A
I
Q
L
A
H
A
Y
A
A
L
A
N
D
G
K
S
V
P
L
S
M
T
R
V
D
R
V
P
D
G
----------------------
V
-
Q
-
V
I
S
P
E
V
A
S
T
V
Q
G
M
L
Q
Q
V
-
V
E
----------
A
-
Q
G
----------
G
V
F
R
-
A
-
Q
V
P
G
Y
H
A
A
G
K
S
G
T
A
-
R
K
--
V
--------------
E
N
A
Y
R
S
L
F
A
G
F
--
A
P
AT
D
P
R
I
A
M
---
V
V
V
--
I
D
E
P
S
K
A
G
Y
F
G
G
L
V
S
A
P
V
F
S
K
V
M
A
G
A
L
R
L
M
N
V
P
P
D
N
L
----------------------------------------------------------------------------------------------------------------------------
34
HHSearch
72.81
21%
-41
- C1 -
3VSK
-
?
A:
[57-678]
---------------------------------------------------
N
D
E
N
I
-
T
V
N
E
S
V
P
R
G
R
I
L
D
R
N
G
K
V
L
V
D
N
---
A
S
K
M
A
I
T
Y
T
R
G
R
K
T
-
T
Q
S
E
M
L
D
T
A
E
K
L
S
K
L
I
K
M
D
T
K
K
I
T
E
R
D
---
K
K
D
F
W
I
Q
L
H
P
K
K
A
K
A
M
M
T
K
E
Q
A
M
L
A
DGSIK
Q
D
Q
Y
D
K
Q
L
L
S
K
IRKSQLDELS
S
K
D
L
Q
V
L
A
I
F
R
E
M
N
AGTVL
D
P
Q
M
I
K
N
----------------
E
D
V
S
E
K
E
Y
A
A
V
S
Q
Q
L
S
K
L
P
---------------------
G
V
N
T
-
S
M
D
W
D
R
K
Y
P
Y
G
D
T
L
R
G
I
F
G
D
V
S
T
P
-
A
-
E
-
G
IPKEL
T
E
H
Y
L
S
K
GY
S
R
N
D
R
V
G
K
S
Y
L
E
Y
Q
Y
E
D
V
L
R
G
-
K
K
K
E
M
K
Y
T
T
D
K
S
G
K
V
T
S
S
-
E
V
---
L
N
P
G
A
R
G
Q
D
L
K
L
T
I
D
I
D
L
Q
----
K
E
V
E
A
L
----
L
D
K
Q
I
K
K
L
R
SQGAKD-
M
D
N
A
M
M
V
V
Q
N
P
K
N
G
D
I
L
A
L
A
G
K
Q
I
N
K
----
S
G
K
M
---------------------
T
D
Y
D
I
G
T
F
T
S
Q
F
A
V
G
S
S
V
K
G
G
T
L
L
A
G
Y
Q
N
K
A
I
K
V
G
E
T
M
V
D
E
P
---
L
H
F
Q
-
G
G
--
L
T
K
R
S
------
Y
F
NK--
N
-----
G
H
--
V
-----
S
I
N
D
K
Q
A
L
M
H
S
S
N
V
Y
M
F
K
T
A
L
K
L
-----------
A
GDPYYSGMALPSDI
S
S
P
A
-------
Q
---
K
L
R
R
G
L
N
Q
V
G
L
G
V
K
---
T
G
I
D
L
P
N
E
T
R
G
Q
I
E
P
L
-
T
N
-
N
P
G
N
Y
L
D
L
S
I
G
Q
Y
-
D
T
Y
-------
T
P
L
Q
L
S
Q
Y
V
S
T
I
A
N
D
G
Y
R
I
Q
P
H
I
G
L
T
I
H
E
S
T
N
K
D----
E
V
-
G
P
L
K
K
K
I
N
G
T
V
L
-
N
-
K
V
N
N
T
E
K
E
I
K
Q
I
Q
E
G
F
K
M
A
-
F
N
DK--------
D
-
G
T
----------
G
Y
-
V
-
S
F
K
D
T
V
V
P
T
A
G
K
T
G
T
A
-
E
V
--
F
--
Q
-----------
E
P
R
V
N
S
T
Y
I
G
Y
--
A
P
--
I
D
D
P
K
L
A
F
S
I
V
Y
--
T
N
Q
P
V
-
P
--
P
P
W
L
T
G
G
D
L
G
R
D
V
I
N
Y
Y
F
K
-------------------------------------------------------------------------------------------------------------------------------------
38
HHSearch
71.45
18%
-48
- C1 -
3UN7
-
PBPA_MYCTU
A:
[73-488]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
L
R
V
Y
P
N
P
E
V
Y
A
P
V
T
G
F
Y
S
L
R
-------------------------
Y
S
S
T
A
L
E
R
A
E
D
P
I
L
N
G
-
S
D
R
R
L
F
------
G
R
R
L
A
D
-
F
F
---
T
G
R
D
P
R
G
G
N
V
D
T
T
I
N
P
R
I
Q
----
Q
A
G
W
D
A
----
M
Q
Q
G
C
--
Y
G
-------
P
C
K
G
A
V
V
A
L
E
P
S
T
G
K
I
L
A
L
V
S
S
P
S
Y
D
----
P
N
L
L
A
-
S
H
N
P
E
V
Q
A
Q
A
W
Q
R
L
G
D
NP
A
S
P
L
T
N
R
A
I
S
E
T
Y
P
P
G
S
T
F
K
V
I
T
T
A
A
A
L
A
A
G
A
T
E
T
E
-
Q
L
T
A
A
----
P
T
I
P
L
P
G
ST
A
Q
L
E
N
------
Y
G
GAPC
G
-----
D
E
--
P
-----
T
V
S
L
R
E
A
F
V
K
S
C
N
T
A
F
V
Q
L
G
I
R
T
-----------
G
-----------------
A
-------
D
---
A
L
R
S
M
A
R
A
F
G
L
D
S
P
P
R
P
T
P
L
Q
V
A
E
S
T
V
G
P
I
P
D
------
S
A
A
L
G
M
T
S
I
G
Q
K
D
V
A
L
-------
T
P
L
A
N
A
E
I
A
A
T
I
A
N
G
G
I
T
M
R
P
Y
L
V
G
S
L
K
G
P
D
L
A
-----
N
I
-
S
T
T
V
R
----
Y
Q
Q
-
R
-
R
-
A
V
S
P
Q
V
A
A
K
L
T
E
L
M
V
G
A
-
E
K
----------
V
-------------
Q
--
K
-
G
-
A
I
P
G
V
Q
I
A
S
K
T
G
T
A
-
E
H
--
G
--
T
D
------
P
R
--
H
T
P
P
H
A
W
Y
I
A
F
--
A
P
--
A
Q
A
P
K
V
A
V
A
V
L
V
--
E
N
G
A
D
R
L
S
A
T
G
G
A
L
A
A
P
I
G
R
A
V
I
E
A
A
L
Q
-------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
70.89
30%
-50
- C1 -
4U3T
-
PBP2_NEIGO
A:
[6-312]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
D
----
Q
R
I
Q
T
L
A
Y
E
E
L
N
K
A
V
E
Y
H
Q
-------
A
K
A
G
T
V
V
V
L
D
A
R
T
G
E
I
L
A
L
A
N
T
---------------------------------
P
G
R
N
R
A
V
T
D
M
I
-
E
P
G
S
A
I
K
P
F
V
I
A
K
A
L
D
A
G
K
T
D
L
N
E
R
--
L
N
T
---
Q
P
Y
K
I
G
P
--
S
P
V
R
D
------
D
T
----
H
-----
V
Y
--
P
-----
S
L
D
V
R
G
I
M
Q
K
S
S
N
V
G
T
S
K
L
S
A
R
F
-----------
G
-----------------
A
-------
E
E
M
Y
D
F
Y
H
-
E
L
G
I
G
V
R
M
H
---
S
G
--
F
P
G
E
T
A
G
L
L
R
N
W
R
R
W
-
R
P
I
E
Q
A
T
M
S
F
G
Y
G
-
L
Q
L
-------
S
L
L
Q
L
A
R
A
Y
T
A
L
T
H
D
G
V
L
L
P
L
S
F
E
K
Q
A
V
A
P
Q
G
K
-----------------------
R
-
I
F
K
E
S
T
A
R
E
V
R
N
L
M
V
S
V
-
T
E
P---------
G
-
G
T
----------
G
T
-
A
-
G
-
A
V
D
G
F
D
V
G
A
K
T
G
T
A
-
R
K
--
L
--
V
N
--
G
R
--
Y
V
--
D
N
K
H
V
G
T
F
I
G
F
--
A
P
--
A
K
N
P
R
V
I
V
A
V
T
I
D
E
P
T
A
H
G
-------
V
V
A
G
S
P
F
K
K
I
M
G
G
S
L
N
I
L
G
I
S
P
T
K
P
L
T
A
-------------------------------------------------------------------------------------------------------------------------
35
HHSearch
70.46
19%
-51
- C1 -
2WAD
3
PBP2_STRR6
A:
[50-676]
-----------------------------------------------------
S
Q
T
-
K
V
T
T
S
S
A
R
G
E
I
Y
D
A
S
G
K
P
L
V
E
N
---
T
L
K
Q
V
V
S
F
T
R
S
N
K
M
T
A
-
T
D
L
K
E
I
A
K
K
L
L
T
Y
V
S
I
S
S
P
N
L
T
E
R
Q
---
L
A
D
Y
Y
L
AD
P
E
I
Y
K
K
T
V
E
A
LPE
S
E
L
Y
N
N
A
V
D
S
V
PTSQ
L
N
Y
T
E
D
E
---------------------------
K
K
E
I
Y
L
F
S
Q
L
N
A
VGNF
A
T
G
T
I
A
T
D
P
L
N
D
S
Q
V
A
V
I
A
S
--
I
-------------------
S
K
E
M
P
G
I
S
I
-
S
T
S
W
D
R
K
I
L
E
-
T
S
L
S
S
I
V
G
S
V
S
S
E
-
K
-
A
G
L
PAEE
A
E
S
Y
L
K
K
GY-
S
L
N
D
R
V
G
T
S
Y
L
E
K
Q
Y
E
E
V
L
Q
G
-
K
R
P
V
K
E
I
H
L
D
K
H
G
D
M
E
S
V
-
E
N
---
I
E
E
G
S
K
G
K
N
I
K
L
T
I
D
L
A
F
Q
----
D
S
V
D
A
L
----
L
K
S
Y
F
N
S
E
L
G
N
GGAKY
S
E
G
V
Y
A
V
A
L
N
P
Q
T
G
A
V
L
S
M
S
G
L
K
-
H
D
----
L
K
T
G
E
-------------------
L
T
P
D
S
L
G
T
V
T
N
V
F
V
P
G
S
V
V
K
A
A
T
I
S
S
G
W
E
N
G
V
L
S
G
N
Q
T
L
T
D
Q
----
P
-
I
V
F
Q
G
S-
A
P
I
Y
S
------
W
Y
----
K
L----
A
Y
G
S
F
-----
P
I
T
A
V
E
A
L
E
Y
S
S
N
A
Y
V
V
Q
T
A
L
G
I
M
G
Q
T
Y
Q
P
N
M
F
V
G
-----------------
T
SN
L
E
S
A
M
G
---
K
L
R
S
T
F
G
E
Y
G
L
G
S
A
---
T
G
I
D
L
P
D
E
S
T
G
L
V
P
K
--
E
Y
-
N
F
A
N
F
I
T
N
A
F
G
Q
F
-
D
N
Y
-------
T
P
M
Q
L
A
Q
Y
V
A
T
I
A
N
N
G
V
R
L
A
P
H
I
V
E
G
I
Y
D
N
N
D
K
G
G
L
G
E
L
I
-
Q
A
I
D
T
----
K
E
I
N
K
-
V
-
N
I
S
E
S
D
M
A
I
L
H
Q
G
F
Y
Q
V
-
S
H
------------
G
T
SPLTT-----
G
R
-
A
-
F
S
D
G
A
T
V
S
I
S
G
K
T
G
T
-------------------------
N
T
N
A
V
A
Y
--
A
P
--
T
E
N
P
Q
I
A
V
A
V
V
F
--
P
H
N
T
N
----
L
T
K
N
V
G
P
A
I
A
R
D
I
I
N
L
Y
N
Q
H
H
P
M
N
--------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
69.84
23%
-36
- C1 -
4N1X
1
?
A:
[70-465]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
N
Y
P
H
D
G
M
A
S
H
T
V
G
Y
I
S
T
Q
-
Y
------------------------
G
T
A
G
I
E
S
S
M
N
E
T
L
T
--------
D
W
R
S
A
L
Y
S
M
A
G
I
-
N
T
--------
T
G
S
S
V
V
L
T
I
N
S
Q
M
Q
----
A
V
A
E
A
A
----
L
Q
G
Y
S
G
S
I
V
--------------
V
M
D
P
S
T
G
A
V
L
A
K
A
S
S
P
S
Y
T
H
A
E
L
G
T
-----------------------
S
Q
L
V
D
R
T
T
Q
A
L
Y
S
P
G
S
S
F
K
T
V
T
L
A
A
G
I
D
T
H
----
K
T
T
L
D
T
T
Y
S
A
P
G
T
M
E
I
G
G
--
G
T
I
H
N
YANEDM
G
T
----
I
-----
P
L
--
R
-----
E
A
-----
F
A
R
S
S
N
T
A
L
A
Q
L
G
V
A
L
-----------
G
-----------------
A
-------
D
---
N
L
V
S
Y
A
R
A
F
G
Y
G
T
A
---
L
G
Q
D
F
S
T
T
P
S
L
M
P
N
P
A
E
M
T
T
W
E
L
A
W
A
S
C
G
L
P
V
G
-
E
H
A
SPAGP
Q
T
T
V
M
Q
N
A
V
I
A
A
A
I
A
N
G
G
V
V
M
N
P
Y
I
V
D
R
V
L
S
P
E
G
A
-----
V
V
S
T
T
-
S
P
----
K
S
L
-
G
-
Q
-
A
V
S
A
D
T
A
A
Q
V
R
E
A
M
L
G
V
-
V
E
----------
S
-
G
T
----------
G
M
-
G
-
A
-
R
V
P
G
V
K
I
A
G
K
T
G
T
A
-
D
V
-----
E
N
--
G
---------
N
F
N
S
F
F
I
G
F
--
A
P
--
Y
D
H
P
T
L
V
V
S
V
V
I
--
E
G
N
G
E
N
V
L
G
Y
G
A
Q
V
G
G
R
V
L
A
Q
C
L
N
I
Q
A
--------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
68.32
23%
-37
- C1 -
4R3J
4
?
A:
[80-475]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
N
Y
P
H
D
G
M
A
S
H
T
V
G
Y
I
S
T
Q
-
Y
------------------------
G
T
A
G
I
E
S
S
M
N
E
T
L
T
G
------------------------------
T
G
S
S
V
V
L
T
I
N
S
Q
M
Q
----
A
V
A
E
A
A
----
L
Q
G
Y
S
G
S
I
V
--------------
V
M
D
P
S
T
G
A
V
L
A
K
A
S
S
P
S
Y
T
HAE
L
G
T
I
I
E
-
S
G
T
---------------
G
S
Q
L
V
D
R
T
T
Q
A
L
Y
S
P
G
S
S
F
K
T
V
T
L
A
A
G
I
D
T
H
----
K
T
T
L
D
T
T
Y
S
A
P
G
T
M
E
I
G
G
--
G
T
I
H
N
YANEDM
G
T
----
I
-----
P
L
--
R
-----
E
A
-----
F
A
R
S
S
N
T
A
L
A
Q
L
G
V
A
L
-----------
G
-----------------
A
-------
D
---
N
L
V
S
Y
A
R
A
F
G
Y
G
T
A
---
L
G
Q
D
F
S
T
T
P
S
L
M
P
N
P
A
E
M
T
T
W
E
L
A
W
A
S
C
G
L
P
V
G
-
E
H
A
SPAGP
Q
T
T
V
M
Q
N
A
V
I
A
A
A
I
A
N
G
G
V
V
M
N
P
Y
I
V
D
R
V
L
S
P
E
G
A
-----
V
V
S
T
T
-
S
P
----
K
S
L
-
G
-
Q
-
A
V
S
A
D
T
A
A
Q
V
R
E
A
M
L
G
V
-
V
E
----------
S
-
G
T
----------
G
M
-
G
-
A
-
R
V
P
G
V
K
I
A
G
K
T
G
T
A
-
D
-------
N
--
G
---------
N
F
N
S
F
F
I
G
F
--
A
P
--
Y
D
H
P
T
L
V
V
S
V
V
I
--
E
G
N
G
E
N
V
L
G
Y
G
A
Q
V
G
G
R
V
L
A
Q
C
L
N
I
Q
A
L
G
A
A
S
---------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
68.05
23%
-36
- C1 -
4R23
7
?
A:
[80-475]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
N
Y
P
H
D
G
M
A
S
H
T
V
G
Y
I
S
T
Q
-
Y
------------------------
G
T
A
G
I
E
S
S
M
N
E
T
L
T
G
H
--------
R
S
A
L
Y
S
M
A
G
I
--
T
--------
T
G
S
S
V
V
L
T
I
N
S
Q
M
Q
----
A
V
A
E
A
A
----
L
Q
G
Y
S
G
S
I
V
--------------
V
M
D
P
S
T
G
A
V
L
A
K
A
S
S
P
S
Y
T
H
A
E
L
G
T
I
----------------------
S
Q
L
V
D
R
T
T
Q
A
L
Y
S
P
G
S
S
F
K
T
V
T
L
A
A
G
I
D
T
H
----
K
T
T
L
D
T
T
Y
S
A
P
G
T
M
E
I
G
G
--
G
T
I
H
N
YANEDM
G
T
----
I
-----
P
L
--
R
-----
E
A
-----
F
A
R
S
S
N
T
A
L
A
Q
L
G
V
A
L
-----------
G
-----------------
A
-------
D
---
N
L
V
S
Y
A
R
A
F
G
Y
G
T
A
---
L
G
Q
D
F
S
T
T
P
S
L
M
P
N
P
A
E
M
T
T
W
E
L
A
W
A
S
C
G
L
P
V
G
-
E
H
A
SPAGP
Q
T
T
V
M
Q
N
A
V
I
A
A
A
I
A
N
G
G
V
V
M
N
P
Y
I
V
D
R
V
L
S
P
E
G
A
-----
V
V
S
T
T
-
S
P
----
K
S
L
-
G
-
Q
-
A
V
S
A
D
T
A
A
Q
V
R
E
A
M
L
G
V
-
V
E
----------
S
-
G
T
----------
G
M
-
G
-
A
-
R
V
P
G
V
K
I
A
G
K
T
G
T
A
-
D
V
-----
E
N
--
G
---------
N
F
N
S
F
F
I
G
F
--
A
P
--
Y
D
H
P
T
L
V
V
S
V
V
I
--
E
G
N
G
E
N
V
L
G
Y
G
A
Q
V
G
G
R
V
L
A
Q
C
L
N
I
Q
A
L
-------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
67.85
23%
-36
- C1 -
4JBF
-
?
A:
[80-475]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
N
Y
P
H
D
G
M
A
S
H
T
V
G
Y
I
S
T
Q
-
Y
------------------------
G
T
A
G
I
E
S
S
M
N
E
T
L
T
--------
D
W
R
S
A
L
Y
S
M
A
G
I
-
N
T
--------
T
G
S
S
V
V
L
T
I
N
S
Q
M
Q
----
A
V
A
E
A
A
----
L
Q
G
Y
S
G
S
I
V
--------------
V
M
D
P
S
T
G
A
V
L
A
K
A
S
S
P
S
Y
T
HAEL
G
T
-----------------------
S
Q
L
V
D
R
T
T
Q
A
L
Y
S
P
G
S
S
F
K
T
V
T
L
A
A
G
I
D
T
H
----
K
T
T
L
D
T
T
Y
S
A
P
G
T
M
E
I
G
G
--
G
T
I
H
N
YANEDM
G
T
----
I
-----
P
L
--
R
-----
E
A
-----
F
A
R
S
S
N
T
A
L
A
Q
L
G
V
A
L
-----------
G
-----------------
A
-------
D
---
N
L
V
S
Y
A
R
A
F
G
Y
G
T
A
---
L
G
Q
D
F
S
T
T
P
S
L
M
P
N
P
A
E
M
T
T
W
E
L
A
W
A
S
C
G
L
P
V
G
-
E
H
A
SPAGP
Q
T
T
V
M
Q
N
A
V
I
A
A
A
I
A
N
G
G
V
V
M
N
P
Y
I
V
D
R
V
L
S
P
E
-
A
-----
V
V
S
T
T
-
S
P
----
K
S
L
-
G
-
Q
-
A
V
S
A
D
T
A
A
Q
V
R
E
A
M
L
G
V
-
V
E
----------
S
-
G
T
----------
G
M
-
G
-
A
-
R
V
P
G
V
K
I
A
G
K
T
G
T
A
-
D
V
------
N
--
G
---------
N
F
N
S
F
F
I
G
F
--
A
P
--
Y
D
H
P
T
L
V
V
S
V
V
I
--
E
G
N
G
-
N
V
L
G
Y
G
A
Q
V
G
G
R
V
L
A
Q
C
L
N
I
Q
A
L
-------------------------------------------------------------------------------------------------------------------------------------