@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo0002: (2016-03-11 )
MKFVIERDRLVQAVNEVTRAISARTTIPILTGIKIVVNDEGVTLTGSDSDISIEAFIPLIENDEVIVEVESFGGIVLQSKYFGDIVRRLPEENVEIEVTSNYQTNISSGQASFTLNGLDPMEYPKLPEVTDGKTIKIPINVLKNIVRQTVFAVSAIEVRPVLTGVNWIIKENKLSAVATDSHRLALREIPLETDIDEEYNIVIPGKSLSELNKLLDDASESIEMTLANNQILFKLKDLLFYSRLLEGSYPDTSRLIPTDTKSELVINSKAFLQAIDRASLLARENRNNVIKLMTLENGQVEVSSNSPEVGNVSENVFSQSFTGEEIKISFNGKYMMDALRAFEGDDIQISFSGTMRPFVLRPKDAANPNEILQLITPVRTY
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........-100.......110.......120.......130.......140.......150.......160.......170..-......180.......190.......200.......210......-.220.......230.......240.......250.......260.......270.......280...-....290.......300.......310.......320.......330.......340.......350.......360.......370.......380
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MKFVI
E
R
D
R
L
V
Q
A
V
N
E
V
T
R
A
ISART
T
I
P
I
L
T
G
I
K
I
V
V
NDE
G
V
T
L
TGSDS
D
I
S
I
E
A
F
I
P
LIEN
D
E
V
I
V
E
V
ESF
G
G
I
V
L
Q
S
K
Y
F
G
D
I
V
R
RLPEEN
V
E
I
E
V
T-SNYQTNISSGQ
A
S
F
T
LNGLDPMEYPKLPEVTDG
K
T
I
K
I
P
I
N
V
L
K
N
I
V
R
Q
T
V
F
A
V
S
A
I
E
V
R
P
V
LTG
V
N
W
I
I
KE-N
K
-
L
S
A
VATDS
H
R
L
A
L
R
EIPLETDIDEE
Y
N
I
V
IPGK
S
L
S
E
L
N
K
L
L
D
D
A
-SE
S
I
E
M
T
LAN
N
Q
I
L
F
K
L
K
D
L
L
F
Y
S
R
L
LEGSYPDTSRLIPTDTKS
E
L
V
IN
S
K
A
F
L
Q
A
I
D
R
A
S
L
L
A
REN-RN
N
V
I
K
L
M
T
LEN
G
Q
V
E
VSSNSPEVG
N
V
S
E
N
V
F
SQSFTG
E
E
I
K
I
S
FN
G
K
Y
M
M
D
A
L
R
AFEGD
D
I
Q
I
S
FSGTM
R
P
F
V
LRPKDAA
N
P
N
E
I
L
Q
L
ITPVRTY
1
PsiBlast_PDB
96.41
40%
-115
- C2 -
2AWA
1
DPO3B_STRPN
A:
[16-389]
--
F
S
I
N
K
N
L
F
L
Q
A
L
N
T
T
K
R
A
I
S
S
K
N
A
I
P
I
L
S
T
V
K
I
D
V
T
N
E
G
I
T
L
I
G
S
N
G
Q
I
S
I
E
N
F
I
S
Q
-
K
N
E
D
A
G
L
L
I
T
S
L
G
S
I
L
L
E
A
S
F
F
I
N
V
V
S
S
L
P
D
V
T
L
D
F
K
E
I
-
E
Q
N
Q
I
V
L
T
S
G
K
S
E
I
T
L
K
G
K
D
S
E
Q
Y
P
R
I
Q
E
I
S
A
S
T
P
L
I
L
E
T
K
L
L
K
K
I
I
N
E
T
A
F
A
A
S
T
Q
E
S
R
P
I
L
T
G
V
H
F
V
L
S
Q
-
H
K
E
L
K
T
V
A
T
D
S
H
R
L
S
Q
K
K
L
T
L
E
K
N
S
D
D
-
F
D
V
V
I
P
S
R
S
L
R
E
F
S
A
V
F
T
D
D
-
I
E
T
V
E
I
F
F
A
N
N
Q
I
L
F
R
S
E
N
I
S
F
Y
T
R
L
L
E
G
N
Y
P
D
T
D
R
L
I
P
T
D
F
N
T
T
I
T
F
N
V
V
N
L
R
Q
S
M
E
R
A
R
L
L
S
S
A
T
-
Q
N
G
T
V
K
L
-
E
I
K
D
G
V
V
S
A
H
V
H
S
P
E
V
G
K
V
N
E
E
I
D
T
D
Q
V
T
G
E
D
L
T
I
S
F
N
P
T
Y
L
I
D
S
L
K
A
L
N
S
E
K
V
T
I
S
F
I
S
A
V
R
P
F
T
L
V
P
A
D
T
--
D
E
D
F
M
Q
L
I
T
P
V
R
T
-
2
PsiBlast_PDB
92.79
38%
-114
- C2 -
2AVT
-
?
A:
[2-377]
I
Q
F
S
I
N
R
T
L
F
I
H
A
L
N
T
T
K
R
A
I
S
T
K
N
A
I
P
I
L
S
S
I
K
I
E
V
T
S
T
G
V
T
L
T
G
S
N
G
Q
I
S
I
E
N
T
I
P
-
V
-----
G
L
L
I
T
S
P
G
A
I
L
L
E
A
S
F
F
I
N
I
I
S
S
L
P
D
I
S
I
N
V
K
E
I
-
E
Q
H
Q
V
V
L
T
S
G
K
S
E
I
T
L
K
G
K
D
V
D
Q
Y
P
R
L
Q
E
V
S
T
E
N
P
L
I
L
K
T
K
L
L
K
S
I
I
A
E
T
A
F
A
A
S
L
Q
E
S
R
P
I
L
T
G
V
H
I
V
L
S
N
-
H
K
D
F
K
A
V
A
T
D
S
H
R
M
S
Q
R
L
I
T
L
D
-
N
T
S
A
D
F
M
V
V
L
P
S
K
S
L
R
E
F
S
A
V
F
T
D
D
-
I
E
T
V
E
V
F
F
S
P
S
Q
I
L
F
R
S
E
H
I
S
F
Y
T
R
L
L
E
G
N
Y
P
D
T
D
R
L
L
M
T
E
F
E
T
E
V
V
F
N
T
Q
S
L
R
H
A
M
E
R
A
F
L
I
S
N
A
T
-
Q
N
G
T
V
K
L
E
I
T
Q
N
-
H
I
S
A
H
V
N
S
P
E
V
G
K
V
N
E
D
L
D
I
V
S
Q
S
G
S
D
L
T
I
S
F
N
P
T
Y
L
I
E
S
L
K
A
I
K
S
E
T
V
K
I
H
F
L
S
P
V
R
P
F
T
L
T
P
G
D
E
E
--
E
S
F
I
Q
L
I
T
P
V
R
T
-
22
HHSearch
91.30
38%
-114
- C2 -
2AVT
-
?
A:
[2-377]
I
Q
F
S
I
N
R
T
L
F
I
H
A
L
N
T
T
K
R
A
I
S
T
K
N
A
I
P
I
L
S
S
I
K
I
E
V
T
S
T
G
V
T
L
T
G
S
N
G
Q
I
S
I
E
N
T
I
P
V
------
G
L
L
I
T
S
P
G
A
I
L
L
E
A
S
F
F
I
N
I
I
S
S
L
P
D
I
S
I
N
V
K
E
I
-
E
Q
H
Q
V
V
L
T
S
G
K
S
E
I
T
L
K
G
K
D
V
D
Q
Y
P
R
L
Q
E
V
S
T
E
N
P
L
I
L
K
T
K
L
L
K
S
I
I
A
E
T
A
F
A
A
S
L
Q
E
S
R
P
I
L
T
G
V
H
I
V
L
S
N
H
K
D
-
F
K
A
V
A
T
D
S
H
R
M
S
Q
R
L
I
T
L
D
N
T
-
S
A
D
F
M
V
V
L
P
S
K
S
L
R
E
F
S
A
V
F
T
D
D
-
I
E
T
V
E
V
F
F
S
P
S
Q
I
L
F
R
S
E
H
I
S
F
Y
T
R
L
L
E
G
N
Y
P
D
T
D
R
L
L
M
T
E
F
E
T
E
V
V
F
N
T
Q
S
L
R
H
A
M
E
R
A
F
L
I
S
N
A
T
Q
N
G
-
T
V
K
L
-
E
I
T
Q
N
H
I
S
A
H
V
N
S
P
E
V
G
K
V
N
E
D
L
D
I
V
S
Q
S
G
S
D
L
T
I
S
F
N
P
T
Y
L
I
E
S
L
K
A
I
K
S
E
T
V
K
I
H
F
L
S
P
V
R
P
F
T
L
T
P
G
D
E
E
--
E
S
F
I
Q
L
I
T
P
V
R
T
-
23
HHSearch
85.46
31%
-116
- C2 -
3T0P
14
?
A:
[2-366]
M
K
L
I
C
S
K
A
N
L
L
K
G
V
N
I
V
S
K
A
V
P
T
R
T
T
M
A
I
L
E
C
I
L
I
D
A
S
A
N
E
I
K
L
M
A
N
D
M
E
L
G
I
E
T
I
I
D
--------
G
T
I
E
E
R
G
I
I
A
L
D
A
K
I
F
S
E
I
V
R
K
L
P
D
N
D
V
T
I
E
T
D
-
A
S
F
K
T
V
I
S
C
E
K
A
K
F
N
I
I
G
K
S
G
D
D
F
S
Y
I
P
Y
V
E
R
N
E
S
I
V
L
S
Q
F
T
L
K
E
V
I
R
Q
T
I
F
S
I
A
D
N
D
N
N
K
L
M
T
G
E
L
F
E
I
E
E
-
N
K
-
L
R
V
V
S
L
D
G
H
R
I
S
I
R
Y
I
E
M
K
N
H
-
Y
D
S
K
K
V
V
V
P
G
K
T
L
Q
E
I
S
K
I
I
P
G
S
A
D
E
D
V
V
I
Y
I
T
N
N
H
I
V
F
E
F
E
N
T
T
V
V
S
R
L
I
E
G
E
Y
F
K
I
D
Q
M
L
S
S
D
Y
D
T
K
V
R
I
N
K
R
E
L
L
D
C
I
D
R
A
T
L
L
V
K
E
D
-
K
K
-
P
I
I
M
-
N
I
T
D
G
N
M
E
L
R
I
N
S
-
F
I
G
S
M
N
E
D
I
D
I
-
D
K
D
G
K
D
I
M
I
G
F
N
P
K
F
F
I
D
A
L
R
V
I
D
E
E
E
V
N
L
Y
M
V
N
P
K
A
P
C
F
I
K
D
D
E
G
----
K
F
I
Y
L
I
L
P
V
N
F
-
21
HHSearch
78.81
25%
-110
- C2 -
1VPK
-
?
A:
[1-366]
M
K
V
T
V
T
T
L
E
L
K
D
K
I
T
I
A
S
K
A
L
A
K
K
S
V
K
P
I
L
A
G
F
L
F
E
V
K
D
G
N
F
Y
I
C
A
T
D
L
E
T
G
V
K
A
T
V
N
A
-------
A
E
I
S
G
E
A
R
F
V
V
P
G
D
V
I
Q
K
M
V
K
V
L
P
D
E
I
T
E
L
-
S
L
-
E
G
D
A
L
V
I
S
S
G
S
T
V
F
R
I
T
T
M
P
A
D
E
F
P
E
I
T
P
A
E
S
G
I
T
F
E
V
D
T
S
L
L
E
E
M
V
E
K
V
I
F
A
A
A
K
D
E
F
M
R
N
L
N
G
V
F
W
E
L
H
K
-
N
L
-
L
R
L
V
A
S
D
G
F
R
L
A
L
A
E
E
Q
I
E
N
--
E
E
E
A
S
F
L
L
S
L
K
S
M
K
E
V
Q
N
V
L
D
N
T
T
E
P
T
I
T
V
R
Y
D
G
R
R
V
S
L
S
T
N
D
V
E
T
V
M
R
V
V
D
A
E
F
P
D
Y
K
R
V
I
P
E
T
F
K
T
K
V
V
V
S
R
K
E
L
R
E
S
L
K
R
V
M
V
I
A
S
K
G
-
S
E
-
S
V
K
F
-
E
I
E
E
N
V
M
R
L
V
S
K
S
P
D
Y
G
E
V
V
D
E
V
E
V
-
Q
K
E
G
E
D
L
V
I
A
F
N
P
K
F
I
E
D
V
L
K
H
I
E
T
E
E
I
E
M
N
F
V
D
S
T
S
P
C
Q
I
N
P
L
D
I
S
---
G
Y
L
Y
I
V
M
P
I
R
L
A
16
PsiBlast_PDB
75.19
28%
-104
- C2 -
4K3M
6
DPO3B_ECOLI
A:
[1-341]
M
K
F
T
V
E
R
E
H
L
L
K
P
L
Q
Q
V
S
G
-------
L
P
I
L
G
N
L
L
L
Q
V
A
D
G
T
L
S
L
T
G
T
D
L
E
M
E
M
V
A
R
V
A
L
V
Q
P
H
E
P
-------
G
A
T
T
V
P
A
R
K
F
F
D
I
C
R
G
L
P
E
-
G
A
E
I
A
V
Q
L
E
G
E
R
M
L
V
R
S
G
R
S
R
F
S
L
S
T
L
P
A
A
D
F
P
N
L
D
D
W
Q
S
E
V
E
F
T
L
P
Q
A
T
M
K
R
L
I
E
A
T
Q
F
S
M
A
H
Q
D
V
R
Y
Y
L
N
G
M
L
F
E
T
E
G
-
E
E
-
L
R
T
V
A
T
D
G
H
R
L
A
V
C
S
M
P
I
G
Q
S
L
-
P
S
H
S
V
I
V
P
R
K
G
V
I
E
L
M
R
M
L
D
G
G
-
D
N
P
L
R
V
Q
I
G
S
N
N
I
R
A
H
V
G
D
F
I
F
T
S
K
L
V
D
G
R
F
P
D
Y
R
R
V
L
P
K
N
P
D
K
H
L
E
A
G
C
D
L
L
K
Q
A
F
A
R
A
A
I
L
S
N
E
K
-
F
R
G
V
-
R
L
Y
V
S
E
N
-
Q
L
K
I
T
A
N
N
P
E
-
Q
E
E
A
E
E
I
L
D
V
T
Y
S
G
A
E
M
E
I
G
F
N
V
S
Y
V
L
D
V
L
N
A
L
K
C
E
N
V
R
M
M
L
T
-----------------------------
19
PsiBlast_PDB
74.52
28%
-105
- C2 -
4K3Q
12
DPO3B_ECOLI
A:
[1-341]
M
K
F
T
V
E
R
E
H
L
L
K
P
L
Q
Q
V
S
G
-------
L
P
I
L
G
N
L
L
L
Q
V
A
D
G
T
L
S
L
T
G
T
D
L
E
M
E
M
V
A
R
V
A
L
V
Q
P
H
E
P
-------
G
A
T
T
V
P
A
R
K
F
F
D
I
C
R
G
L
P
E
-
G
A
E
I
A
V
Q
L
E
G
E
R
M
L
V
R
S
G
R
S
R
F
S
L
S
T
L
P
A
A
D
F
P
N
L
D
D
W
Q
S
E
V
E
F
T
L
P
Q
A
T
M
K
R
L
I
E
A
T
Q
F
S
M
A
H
Q
D
V
R
Y
Y
L
N
G
M
L
F
E
T
E
G
-
E
E
-
L
R
T
V
A
T
D
G
H
R
L
A
V
C
S
M
P
I
G
Q
S
L
-
P
S
H
S
V
I
V
P
R
K
G
V
I
E
L
M
R
M
L
D
G
G
-
D
N
P
L
R
V
Q
I
G
S
N
N
I
R
A
H
V
G
D
F
I
F
T
S
K
L
V
D
G
R
F
P
D
Y
R
R
V
L
P
K
N
P
D
K
H
L
E
A
G
C
D
L
L
K
Q
A
F
A
R
A
A
I
L
S
N
E
K
-
F
R
G
V
-
R
L
Y
V
S
E
N
-
Q
L
K
I
T
A
N
N
P
E
-
Q
E
E
A
E
E
I
L
D
V
T
Y
S
G
A
E
M
E
I
G
F
N
V
S
Y
V
L
D
V
L
N
A
L
K
C
E
N
V
R
M
M
L
T
-----------------------------
9
PsiBlast_PDB
74.50
28%
-102
- C2 -
3D1F
3
DPO3B_ECOLI
A:
[1-341]
M
K
F
T
V
E
R
E
H
L
L
K
P
L
Q
Q
V
S
G
P
L
G
G
R
P
T
L
P
I
L
G
N
L
L
L
Q
V
A
D
G
T
L
S
L
T
G
T
D
L
E
M
E
M
V
A
R
V
A
L
V
Q
P
H
E
P
-------
G
A
T
T
V
P
A
R
K
F
F
D
I
C
R
G
L
P
E
-
G
A
E
I
A
V
Q
L
E
G
E
R
M
L
V
R
S
G
R
S
R
F
S
L
S
T
L
P
A
A
D
F
P
N
L
D
D
W
Q
S
E
V
E
F
T
L
P
Q
A
T
M
K
R
L
I
E
A
T
Q
F
S
M
A
H
Q
D
V
R
Y
Y
L
N
G
M
L
F
E
T
E
G
-
E
E
-
L
R
T
V
A
T
D
G
H
R
L
A
V
C
S
M
P
I
G
Q
S
L
-
P
S
H
S
V
I
V
P
R
K
G
V
I
E
L
M
R
M
L
D
G
G
-
D
N
P
L
R
V
Q
I
G
S
N
N
I
R
A
H
V
G
D
F
I
F
T
S
K
L
V
D
G
R
F
P
D
Y
R
R
V
L
P
K
N
P
D
K
H
L
E
A
G
C
D
L
L
K
Q
A
F
A
R
A
A
I
L
S
N
E
K
-
F
R
G
V
-
R
L
Y
V
S
E
N
-
Q
L
K
I
T
A
N
N
P
E
-
Q
E
E
A
E
E
I
L
D
V
T
Y
S
G
A
E
M
E
I
G
F
N
V
S
Y
V
L
D
V
L
N
A
L
K
C
E
N
V
R
M
M
L
T
-----------------------------
13
PsiBlast_PDB
74.31
28%
-107
- C2 -
3Q4K
1
DPO3B_ECOLI
A:
[1-341]
M
K
F
T
V
E
R
E
H
L
L
K
P
L
Q
Q
V
S
-------
T
L
P
I
L
G
N
L
L
L
Q
V
A
D
G
T
L
S
L
T
G
T
D
L
E
M
E
M
V
A
R
V
A
L
V
Q
P
H
E
P
-------
G
A
T
T
V
P
A
R
K
F
F
D
I
C
R
G
L
P
E
-
G
A
E
I
A
V
Q
L
E
G
E
R
M
L
V
R
S
G
R
S
R
F
S
L
S
T
L
P
A
A
D
F
P
N
L
D
D
W
Q
S
E
V
E
F
T
L
P
Q
A
T
M
K
R
L
I
E
A
T
Q
F
S
M
A
H
Q
D
V
R
Y
Y
L
N
G
M
L
F
E
T
E
G
-
E
E
-
L
R
T
V
A
T
D
G
H
R
L
A
V
C
S
M
P
I
G
Q
S
L
-
P
S
H
S
V
I
V
P
R
K
G
V
I
E
L
M
R
M
L
D
G
G
-
D
N
P
L
R
V
Q
I
G
S
N
N
I
R
A
H
V
G
D
F
I
F
T
S
K
L
V
D
G
R
F
P
D
Y
R
R
V
L
P
--
P
D
K
H
L
E
A
G
C
D
L
L
K
Q
A
F
A
R
A
A
I
L
S
N
E
K
-
F
R
G
V
-
R
L
Y
V
S
E
N
-
Q
L
K
I
T
A
N
N
P
E
-
Q
E
E
A
E
E
I
L
D
V
T
Y
S
G
A
E
M
E
I
G
F
N
V
S
Y
V
L
D
V
L
N
A
L
K
C
E
N
V
R
M
M
L
T
-----------------------------
5
PsiBlast_PDB
74.09
28%
-103
- C2 -
1UNN
-
DPO3B_ECOLI
A:
[1-341]
M
K
F
T
V
E
R
E
H
L
L
K
P
L
Q
Q
V
S
G
P
L
G
G
R
P
T
L
P
I
L
G
N
L
L
L
Q
V
A
D
G
T
L
S
L
T
G
T
D
L
E
M
E
M
V
A
R
V
A
L
V
Q
P
H
E
P
-------
G
A
T
T
V
P
A
R
K
F
F
D
I
C
R
G
L
P
E
-
G
A
E
I
A
V
Q
L
E
G
E
R
M
L
V
R
S
G
R
S
R
F
S
L
S
T
L
P
A
A
D
F
P
N
L
D
D
W
Q
S
E
V
E
F
T
L
P
Q
A
T
M
K
R
L
I
E
A
T
Q
F
S
M
A
H
Q
D
V
R
Y
Y
L
N
G
M
L
F
E
T
E
G
-
E
E
-
L
R
T
V
A
T
D
G
H
R
L
A
V
C
S
M
P
I
G
Q
S
L
-
P
S
H
S
V
I
V
P
R
K
G
V
I
E
L
M
R
M
L
D
G
G
-
D
N
P
L
R
V
Q
I
G
S
N
N
I
R
A
H
V
G
D
F
I
F
T
S
K
L
V
D
G
R
F
P
D
Y
R
R
V
L
P
K
N
P
D
K
H
L
E
A
G
C
D
L
L
K
Q
A
F
A
R
A
A
I
L
S
N
E
K
-
F
R
G
V
-
R
L
Y
V
S
E
N
-
Q
L
K
I
T
A
N
N
P
E
-
Q
E
E
A
E
E
I
L
D
V
T
Y
S
G
A
E
M
E
I
G
F
N
V
S
Y
V
L
D
V
L
N
A
L
K
C
E
N
V
R
M
M
L
T
-----------------------------
15
PsiBlast_PDB
74.04
28%
-107
- C2 -
4K3L
7
DPO3B_ECOLI
A:
[1-341]
M
K
F
T
V
E
R
E
H
L
L
K
P
L
Q
Q
V
S
---------
P
I
L
G
N
L
L
L
Q
V
A
D
G
T
L
S
L
T
G
T
D
L
E
M
E
M
V
A
R
V
A
L
V
Q
P
H
E
P
-------
G
A
T
T
V
P
A
R
K
F
F
D
I
C
R
G
L
P
E
-
G
A
E
I
A
V
Q
L
E
G
E
R
M
L
V
R
S
G
R
S
R
F
S
L
S
T
L
P
A
A
D
F
P
N
L
D
D
W
Q
S
E
V
E
F
T
L
P
Q
A
T
M
K
R
L
I
E
A
T
Q
F
S
M
A
H
Q
D
V
R
Y
Y
L
N
G
M
L
F
E
T
E
G
-
E
E
-
L
R
T
V
A
T
D
G
H
R
L
A
V
C
S
M
P
I
G
Q
S
L
-
P
S
H
S
V
I
V
P
R
K
G
V
I
E
L
M
R
M
L
D
----
N
P
L
R
V
Q
I
G
S
N
N
I
R
A
H
V
G
D
F
I
F
T
S
K
L
V
D
G
R
F
P
D
Y
R
R
V
L
P
K
N
P
D
K
H
L
E
A
G
C
D
L
L
K
Q
A
F
A
R
A
A
I
L
S
N
E
K
-
F
R
G
V
-
R
L
Y
V
S
E
N
-
Q
L
K
I
T
A
N
N
P
E
-
Q
E
E
A
E
E
I
L
D
V
T
Y
S
G
A
E
M
E
I
G
F
N
V
S
Y
V
L
D
V
L
N
A
L
K
C
E
N
V
R
M
M
L
T
-----------------------------
7
PsiBlast_PDB
73.84
28%
-100
- C2 -
3BEP
2
DPO3B_ECOLI
A:
[1-341]
M
K
F
T
V
E
R
E
H
L
L
K
P
L
Q
Q
V
S
G
P
L
G
G
R
P
T
L
P
I
L
G
N
L
L
L
Q
V
A
D
G
T
L
S
L
T
G
T
D
L
E
M
E
M
V
A
R
V
A
L
V
Q
P
H
E
P
-------
G
A
T
T
V
P
A
R
K
F
F
D
I
C
R
G
L
P
E
-
G
A
E
I
A
V
Q
L
E
G
E
R
M
L
V
R
S
G
R
S
R
F
S
L
S
T
L
P
A
A
D
F
P
N
L
D
D
W
Q
S
E
V
E
F
T
L
P
Q
A
T
M
K
R
L
I
E
A
T
Q
F
S
M
A
H
Q
D
V
R
Y
Y
L
N
G
M
L
F
E
T
E
G
-
E
E
-
L
R
T
V
A
T
D
G
H
R
L
A
V
C
S
M
P
I
G
Q
S
L
-
P
S
H
S
V
I
V
P
R
K
G
V
I
E
L
M
R
M
L
D
G
G
-
D
N
P
L
R
V
Q
I
G
S
N
N
I
R
A
H
V
G
D
F
I
F
T
S
K
L
V
D
G
R
F
P
D
Y
R
R
V
L
P
K
N
P
D
K
H
L
E
A
G
C
D
L
L
K
Q
A
F
A
R
A
A
I
L
S
N
E
K
-
F
R
G
V
-
R
L
Y
V
S
E
N
-
Q
L
K
I
T
A
N
N
P
E
-
Q
E
E
A
E
E
I
L
D
V
T
Y
S
G
A
E
M
E
I
G
F
N
V
S
Y
V
L
D
V
L
N
A
L
K
C
E
N
V
R
M
M
L
T
-----------------------------
11
PsiBlast_PDB
73.82
28%
-100
- C2 -
3QSB
1
DPO3B_ECOLI
A:
[1-341]
M
K
F
T
V
E
R
E
H
L
L
K
P
L
Q
Q
V
S
G
P
L
G
G
R
P
T
L
P
I
L
G
N
L
L
L
Q
V
A
D
G
T
L
S
L
T
G
T
D
L
E
M
E
M
V
A
R
V
A
L
V
Q
P
H
E
P
-------
G
A
T
T
V
P
A
R
K
F
F
D
I
C
R
G
L
P
E
-
G
A
E
I
A
V
Q
L
E
G
E
R
M
L
V
R
S
G
R
S
R
F
S
L
S
T
L
P
A
A
D
F
P
N
L
D
D
W
Q
S
E
V
E
F
T
L
P
Q
A
T
M
K
R
L
I
E
A
T
Q
F
S
M
A
H
Q
D
V
R
Y
Y
L
N
G
M
L
F
E
T
E
G
-
E
E
-
L
R
T
V
A
T
D
G
H
R
L
A
V
C
S
M
P
I
G
Q
S
L
-
P
S
H
S
V
I
V
P
R
K
G
V
I
E
L
M
R
M
L
D
G
G
-
D
N
P
L
R
V
Q
I
G
S
N
N
I
R
A
H
V
G
D
F
I
F
T
S
K
L
V
D
G
R
F
P
D
Y
R
R
V
L
P
K
N
P
D
K
H
L
E
A
G
C
D
L
L
K
Q
A
F
A
R
A
A
I
L
S
N
E
K
-
F
R
G
V
-
R
L
Y
V
S
E
N
-
Q
L
K
I
T
A
N
N
P
E
-
Q
E
E
A
E
E
I
L
D
V
T
Y
S
G
A
E
M
E
I
G
F
N
V
S
Y
V
L
D
V
L
N
A
L
K
C
E
N
V
R
M
M
L
T
-----------------------------
17
PsiBlast_PDB
73.66
28%
-105
- C2 -
4K3O
9
DPO3B_ECOLI
A:
[1-341]
M
K
F
T
V
E
R
E
H
L
L
K
P
L
Q
Q
V
S
G
P
L
-----
L
P
I
L
G
N
L
L
L
Q
V
A
D
G
T
L
S
L
T
G
T
D
L
E
M
E
M
V
A
R
V
A
L
V
Q
P
H
E
P
-------
G
A
T
T
V
P
A
R
K
F
F
D
I
C
R
G
L
P
E
-
G
A
E
I
A
V
Q
L
E
G
E
R
M
L
V
R
S
G
R
S
R
F
S
L
S
T
L
P
A
A
D
F
P
N
L
D
D
W
Q
S
E
V
E
F
T
L
P
Q
A
T
M
K
R
L
I
E
A
T
Q
F
S
M
A
H
Q
D
V
R
Y
Y
L
N
G
M
L
F
E
T
E
G
-
E
E
-
L
R
T
V
A
T
D
G
H
R
L
A
V
C
S
M
P
I
G
Q
S
L
-
P
S
H
S
V
I
V
P
R
K
G
V
I
E
L
M
R
M
L
D
G
G
-
D
N
P
L
R
V
Q
I
G
S
N
N
I
R
A
H
V
G
D
F
I
F
T
S
K
L
V
D
G
R
F
P
D
Y
R
R
V
L
P
K
N
P
D
K
H
L
E
A
G
C
D
L
L
K
Q
A
F
A
R
A
A
I
L
S
N
E
K
-
F
R
G
V
-
R
L
Y
V
S
E
N
-
Q
L
K
I
T
A
N
N
P
E
-
Q
E
E
A
E
E
I
L
D
V
T
Y
S
G
A
E
M
E
I
G
F
N
V
S
Y
V
L
D
V
L
N
A
L
K
C
E
N
V
R
M
M
L
T
-----------------------------
6
PsiBlast_PDB
73.28
28%
-101
- C2 -
1OK7
-
DPO3B_ECOLI
A:
[1-341]
M
K
F
T
V
E
R
E
H
L
L
K
P
L
Q
Q
V
S
G
P
L
G
G
R
P
T
L
P
I
L
G
N
L
L
L
Q
V
A
D
G
T
L
S
L
T
G
T
D
L
E
M
E
M
V
A
R
V
A
L
V
Q
P
H
E
P
-------
G
A
T
T
V
P
A
R
K
F
F
D
I
C
R
G
L
P
E
-
G
A
E
I
A
V
Q
L
E
G
E
R
M
L
V
R
S
G
R
S
R
F
S
L
S
T
L
P
A
A
D
F
P
N
L
D
D
W
Q
S
E
V
E
F
T
L
P
Q
A
T
M
K
R
L
I
E
A
T
Q
F
S
M
A
H
Q
D
V
R
Y
Y
L
N
G
M
L
F
E
T
E
G
-
E
E
-
L
R
T
V
A
T
D
G
H
R
L
A
V
C
S
M
P
I
G
Q
S
L
-
P
S
H
S
V
I
V
P
R
K
G
V
I
E
L
M
R
M
L
D
G
G
-
D
N
P
L
R
V
Q
I
G
S
N
N
I
R
A
H
V
G
D
F
I
F
T
S
K
L
V
D
G
R
F
P
D
Y
R
R
V
L
P
K
N
P
D
K
H
L
E
A
G
C
D
L
L
K
Q
A
F
A
R
A
A
I
L
S
N
E
K
-
F
R
G
V
-
R
L
Y
V
S
E
N
-
Q
L
K
I
T
A
N
N
P
E
-
Q
E
E
A
E
E
I
L
D
V
T
Y
S
G
A
E
M
E
I
G
F
N
V
S
Y
V
L
D
V
L
N
A
L
K
C
E
N
V
R
M
M
L
T
-----------------------------
8
PsiBlast_PDB
73.04
28%
-103
- C2 -
3D1E
1
DPO3B_ECOLI
A:
[1-341]
M
K
F
T
V
E
R
E
H
L
L
K
P
L
Q
Q
V
S
G
P
L
G
G
R
P
T
L
P
I
L
G
N
L
L
L
Q
V
A
D
G
T
L
S
L
T
G
T
D
L
E
M
E
M
V
A
R
V
A
L
V
Q
P
H
E
P
-------
G
A
T
T
V
P
A
R
K
F
F
D
I
C
R
G
L
P
E
-
G
A
E
I
A
V
Q
L
E
G
E
R
M
L
V
R
S
G
R
S
R
F
S
L
S
T
L
P
A
A
D
F
P
N
L
D
D
W
Q
S
E
V
E
F
T
L
P
Q
A
T
M
K
R
L
I
E
A
T
Q
F
S
M
A
H
Q
D
V
R
Y
Y
L
N
G
M
L
F
E
T
E
G
-
E
E
-
L
R
T
V
A
T
D
G
H
R
L
A
V
C
S
M
P
I
G
Q
S
L
-
P
S
H
S
V
I
V
P
R
K
G
V
I
E
L
M
R
M
L
D
G
G
-
D
N
P
L
R
V
Q
I
G
S
N
N
I
R
A
H
V
G
D
F
I
F
T
S
K
L
V
D
G
R
F
P
D
Y
R
R
V
L
P
K
N
P
D
K
H
L
E
A
G
C
D
L
L
K
Q
A
F
A
R
A
A
I
L
S
N
E
K
-
F
R
G
V
-
R
L
Y
V
S
E
N
-
Q
L
K
I
T
A
N
N
P
E
-
Q
E
E
A
E
E
I
L
D
V
T
Y
S
G
A
E
M
E
I
G
F
N
V
S
Y
V
L
D
V
L
N
A
L
K
C
E
N
V
R
M
M
L
T
-----------------------------
18
PsiBlast_PDB
72.88
28%
-104
- C2 -
4K3P
6
DPO3B_ECOLI
A:
[1-341]
M
K
F
T
V
E
R
E
H
L
L
K
P
L
Q
Q
V
S
G
--------
P
I
L
G
N
L
L
L
Q
V
A
D
G
T
L
S
L
T
G
T
D
L
E
M
E
M
V
A
R
V
A
L
V
Q
P
H
E
P
-------
G
A
T
T
V
P
A
R
K
F
F
D
I
C
R
G
L
P
E
-
G
A
E
I
A
V
Q
L
E
G
E
R
M
L
V
R
S
G
R
S
R
F
S
L
S
T
L
P
A
A
D
F
P
N
L
D
D
W
Q
S
E
V
E
F
T
L
P
Q
A
T
M
K
R
L
I
E
A
T
Q
F
S
M
A
H
Q
D
V
R
Y
Y
L
N
G
M
L
F
E
T
E
G
-
E
E
-
L
R
T
V
A
T
D
G
H
R
L
A
V
C
S
M
P
I
G
Q
S
L
-
P
S
H
S
V
I
V
P
R
K
G
V
I
E
L
M
R
M
L
D
G
G
-
D
N
P
L
R
V
Q
I
G
S
N
N
I
R
A
H
V
G
D
F
I
F
T
S
K
L
V
D
G
R
F
P
D
Y
R
R
V
L
P
K
N
P
D
K
H
L
E
A
G
C
D
L
L
K
Q
A
F
A
R
A
A
I
L
S
N
E
K
-
F
R
G
V
-
R
L
Y
V
S
E
N
-
Q
L
K
I
T
A
N
N
P
E
-
Q
E
E
A
E
E
I
L
D
V
T
Y
S
G
A
E
M
E
I
G
F
N
V
S
Y
V
L
D
V
L
N
A
L
K
C
E
N
V
R
M
M
L
T
-----------------------------
10
PsiBlast_PDB
72.41
28%
-99
- C2 -
3D1G
1
DPO3B_ECOLI
A:
[1-341]
M
K
F
T
V
E
R
E
H
L
L
K
P
L
Q
Q
V
S
G
P
L
G
G
R
P
T
L
P
I
L
G
N
L
L
L
Q
V
A
D
G
T
L
S
L
T
G
T
D
L
E
M
E
M
V
A
R
V
A
L
V
Q
P
H
E
P
-------
G
A
T
T
V
P
A
R
K
F
F
D
I
C
R
G
L
P
E
-
G
A
E
I
A
V
Q
L
E
G
E
R
M
L
V
R
S
G
R
S
R
F
S
L
S
T
L
P
A
A
D
F
P
N
L
D
D
W
Q
S
E
V
E
F
T
L
P
Q
A
T
M
K
R
L
I
E
A
T
Q
F
S
M
A
H
Q
D
V
R
Y
Y
L
N
G
M
L
F
E
T
E
G
-
E
E
-
L
R
T
V
A
T
D
G
H
R
L
A
V
C
S
M
P
I
G
Q
S
L
-
P
S
H
S
V
I
V
P
R
K
G
V
I
E
L
M
R
M
L
D
G
G
-
D
N
P
L
R
V
Q
I
G
S
N
N
I
R
A
H
V
G
D
F
I
F
T
S
K
L
V
D
G
R
F
P
D
Y
R
R
V
L
P
K
N
P
D
K
H
L
E
A
G
C
D
L
L
K
Q
A
F
A
R
A
A
I
L
S
N
E
K
-
F
R
G
V
-
R
L
Y
V
S
E
N
-
Q
L
K
I
T
A
N
N
P
E
-
Q
E
E
A
E
E
I
L
D
V
T
Y
S
G
A
E
M
E
I
G
F
N
V
S
Y
V
L
D
V
L
N
A
L
K
C
E
N
V
R
M
M
L
T
-----------------------------
12
PsiBlast_PDB
72.21
28%
-103
- C2 -
3Q4J
-
DPO3B_ECOLI
A:
[1-341]
M
K
F
T
V
E
R
E
H
L
L
K
P
L
Q
Q
V
S
G
P
L
G
G
R
P
T
L
P
I
L
G
N
L
L
L
Q
V
A
D
G
T
L
S
L
T
G
T
D
L
E
M
E
M
V
A
R
V
A
L
V
Q
P
H
E
P
-------
G
A
T
T
V
P
A
R
K
F
F
D
I
C
R
G
L
P
E
-
G
A
E
I
A
V
Q
L
E
G
E
R
M
L
V
R
S
G
R
S
R
F
S
L
S
T
L
P
A
A
D
F
P
N
L
D
D
W
Q
S
E
V
E
F
T
L
P
Q
A
T
M
K
R
L
I
E
A
T
Q
F
S
M
A
H
Q
D
V
R
Y
Y
L
N
G
M
L
F
E
T
E
G
-
E
E
-
L
R
T
V
A
T
D
G
H
R
L
A
V
C
S
M
P
I
G
Q
S
L
-
P
S
H
S
V
I
V
P
R
K
G
V
I
E
L
M
R
M
L
D
G
G
-
D
N
P
L
R
V
Q
I
G
S
N
N
I
R
A
H
V
G
D
F
I
F
T
S
K
L
V
D
G
R
F
P
D
Y
R
R
V
L
P
K
N
P
D
K
H
L
E
A
G
C
D
L
L
K
Q
A
F
A
R
A
A
I
L
S
N
E
K
-
F
R
G
V
-
R
L
Y
V
S
E
N
-
Q
L
K
I
T
A
N
N
P
E
-
Q
E
E
A
E
E
I
L
D
V
T
Y
S
G
A
E
M
E
I
G
F
N
V
S
Y
V
L
D
V
L
N
A
L
K
C
E
N
V
R
M
M
L
T
-----------------------------
3
PsiBlast_PDB
72.20
28%
-99
- C2 -
2POL
-
DPO3B_ECOLI
A:
[1-341]
M
K
F
T
V
E
R
E
H
L
L
K
P
L
Q
Q
V
S
G
P
L
G
G
R
P
T
L
P
I
L
G
N
L
L
L
Q
V
A
D
G
T
L
S
L
T
G
T
D
L
E
M
E
M
V
A
R
V
A
L
V
Q
P
H
E
P
-------
G
A
T
T
V
P
A
R
K
F
F
D
I
C
R
G
L
P
E
-
G
A
E
I
A
V
Q
L
E
G
E
R
M
L
V
R
S
G
R
S
R
F
S
L
S
T
L
P
A
A
D
F
P
N
L
D
D
W
Q
S
E
V
E
F
T
L
P
Q
A
T
M
K
R
L
I
E
A
T
Q
F
S
M
A
H
Q
D
V
R
Y
Y
L
N
G
M
L
F
E
T
E
G
-
E
E
-
L
R
T
V
A
T
D
G
H
R
L
A
V
C
S
M
P
I
G
Q
S
L
-
P
S
H
S
V
I
V
P
R
K
G
V
I
E
L
M
R
M
L
D
G
G
-
D
N
P
L
R
V
Q
I
G
S
N
N
I
R
A
H
V
G
D
F
I
F
T
S
K
L
V
D
G
R
F
P
D
Y
R
R
V
L
P
K
N
P
D
K
H
L
E
A
G
C
D
L
L
K
Q
A
F
A
R
A
A
I
L
S
N
E
K
-
F
R
G
V
-
R
L
Y
V
S
E
N
-
Q
L
K
I
T
A
N
N
P
E
-
Q
E
E
A
E
E
I
L
D
V
T
Y
S
G
A
E
M
E
I
G
F
N
V
S
Y
V
L
D
V
L
N
A
L
K
C
E
N
V
R
M
M
L
T
-----------------------------