@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo0028: (2016-03-11 )
MLVKGDTVGIICCSDGRKKEDENRIALLEQVLKTEFSLQVVFAETIFQKAESPFSGTPQARAIELMKLYQRSDVQMIFDISGGDAANQVLPYLDFDIIRNAQKPFVGYSDLTVILNAIYTKTEQMGYNYQLLHLVGKDSELQQSHFRKTFFENRVLISGEQLNEFVWRGGEVIGGNIRCFLKLAGTNFMPDFTNKIILLESLGGKEAKLASYVAQLEQLGAFSKCLGVIVGQHSEAEENGEYERIGRLYQQIGRKYKLPIFRTSEIGHSVDAKPCLIGAKVNVSRETLTNF
Atome Classification :
(20 SA)
--------.........10.--....-...20......-..30........40.---.......50........60........70........80........90........100-.......110.......120-----------.--------------...---------..---------.---130.....---.--.140--.--------------------------...--..----...150..------------------------------..--...160.-.....----------------------..------------170.......180......-.190-.-.-.....200.--......--..210.......220.......230.......240.......250......---.260....--...270.......280.......290
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--------MLVKGD
T
V
G
I
I
C--CSDG-RKKED
E
N
R
I
A
L
-
L
E
Q
V
L
KTEF
S
L
Q
V
V
F
---
A
E
T
I
F
Q
KAESPFSGT
P
Q
A
R
A
I
E
L
M
K
L
Y
Q
RSD
V
Q
M
I
F
DISGGD
A
A
NQVLPYL
D
F
D
I
IRNAQ-KPFVG
Y
S
D
L
T
V
I
L
N
A
I
Y
T
K
T
-----------
E
--------------QMG---------Y
N
---------
Y
---
Q
L
L
H
L
VGK---D--
S
E
----
L
--------------------------
Q
Q
S
--
H
F
----
R
K
T
F
FEN
R
------------------------------
V
L
--I
S
G
E
-
Q
L
-
N
E
F
V
W----------------------RG------------
G
E
V
IGG
N
I
R
C
F
L
K
LAGTNF-MPDF-T-
N
-
K
I
I
L
L
E--S--LGG
K
E
A
--
K
L
A
S
Y
V
A
Q
L
E
Q
L
G
A
F
S
K
C
L
G
V
I
VGQHSEAEENG
E
Y
E
R
I
G
R
L
Y
Q
Q
IG
R
K
YKL---
P
I
F
R
TSEI--GHSVDAKP
C
L
I
G
A
K
V
N
V
S
R
E
T
LTNF
9
PsiBlast_PDB
88.95
24%
-89
- C5 -
3TLZ
4
MCCF_ECOLX
A:
[40-353]
---------
L
A
V
G
D
T
I
G
F
F
S
--
S
S
A
P
-
A
T
V
T
A
K
N
R
F
F
R
G
V
E
F
L
Q
R
K
G
F
K
L
---
V
---
S
G
K
L
T
G
K
T
D
F
Y
R
S
G
T
I
K
E
R
A
Q
E
F
N
E
L
V
Y
N
P
D
I
T
C
I
M
S
T
I
G
G
D
N
S
N
S
L
L
P
F
L
D
Y
D
A
I
I
A
N
P
-
K
I
I
I
G
Y
S
D
T
T
A
L
L
A
G
I
Y
A
K
T
-----------
G
--------------
L
I
T
F--------
Y
G
---------
P
---
A
L
I
P
S
F
G
E
---
H
--
P
P
----
L
V
D
I
T
Y
E
S
F
I
K
I
L
TRKQS
G
I
Y
T
Y
T
L
P
E
K
W
S
--
D
E
----
S
I
N
F
N
E
N
K
------------------------------
I
L
--
R
P
K
K
-
L
Y
K
N
N
C
A
F
----------------------
Y
G
S
G
K
V
E
-------
G
R
V
I
G
G
N
L
N
T
L
T
G
I
W
G
S
E
W
-
M
P
E
I
-
R
-
N
G
D
I
L
F
I
E
--
D
--
S
R
K
S
I
A
--
T
V
E
R
L
F
S
M
L
K
L
N
R
V
F
D
K
V
S
A
I
I
L
G
K
H
E
L
F
D
C
A
G
S
K
R
R
P
Y
E
V
L
T
E
V
L
D
G
K
Q
I
---
P
V
L
D
G
F
D
C
--
S
H
T
H
P
M
L
T
L
P
L
G
V
K
L
A
I
--------
1
PsiBlast_PDB
87.25
27%
-89
- C5 -
4E5S
1
?
A:
[9-317]
---------
L
K
K
G
D
E
I
R
V
I
S
PS
C
S
L
S
-
I
V
S
T
E
N
R
R
L
A
V
-
K
R
L
---
T
E
L
G
F
H
V
T
F
S
TH
A
E
E
I
D
R
F
A
S
S
S
I
S
----
S
R
V
Q
D
L
H
E
A
F
R
D
P
N
V
K
A
I
L
T
T
L
G
G
Y
N
S
N
G
L
L
K
Y
L
D
Y
D
L
I
R
E
N
P
-
K
F
F
C
G
Y
S
D
I
T
A
L
N
N
A
I
Y
T
K
T
-----------
G
--------------
L
V
T
---------
Y
S
---------
G
---
P
H
F
S
S
F
G
M
---
E
--
K
G
----
L
--------------------------
E
Y
T
T
D
Y
F
----
L
Q
C
L
T
S
N
K
------------------------------
P
I
EV
L
P
S
E
-
T
W
-
S
D
D
S
W
YIDQEN
R
K
F
I
K
N
EGYVSI
H
E
G
E
A
T
------------
G
D
I
I
G
G
N
M
S
T
L
N
L
L
Q
G
T
S
Y
-
M
P
N
L
-
K
-
D
-
K
I
L
F
L
E
E
D
S
--
L
T
G
T
S
T
L
K
T
F
D
R
Y
L
H
S
L
M
Q
Q
Q
N
F
K
H
V
K
G
I
V
I
G
K
M
Q
K
G
A
E
C
----
T
I
E
D
I
Q
E
M
I
A
S
K
P
E
L
AH
I
P
I
I
A
N
A
S
F
--
G
H
T
T
P
I
F
T
F
P
I
G
G
R
A
T
I
--------
14
PsiBlast_PDB
85.93
23%
-88
- C5 -
3TLY
4
MCCF_ECOLX
A:
[40-353]
---------
L
A
V
G
D
T
I
G
F
F
S
--
S
S
A
P
-
A
T
V
T
A
K
N
R
F
F
R
G
V
E
F
L
Q
R
K
G
F
K
L
---
V
---
S
G
K
L
T
G
K
T
D
F
Y
R
S
G
T
I
K
E
R
A
Q
E
F
N
E
L
V
Y
N
P
D
I
T
C
I
M
S
T
I
G
G
D
N
S
N
S
L
L
P
F
L
D
Y
D
A
I
I
A
N
P
-
K
I
I
I
G
Y
A
D
T
T
A
L
L
A
G
I
Y
A
K
T
-----------
G
--------------
L
I
T
F--------
Y
G
---------
P
---
A
L
I
P
S
F
G
E
---
H
--
P
P
----
L
V
D
I
T
Y
E
S
F
I
K
I
L
TRKQS
G
I
Y
T
Y
T
L
PE
K
W
S
--
D
E
----
S
I
N
W
N
E
N
K
------------------------------
I
L
--
R
P
K
K
-
L
Y
K
N
N
C
A
F
----------------------
Y
G
S
G
K
V
E
-------
G
R
V
I
G
G
N
L
A
T
L
T
G
I
W
G
S
E
W
-
M
P
E
I
-
R
-
N
G
D
I
L
F
I
E
--
D
--
S
R
A
S
I
A
--
T
V
E
R
L
F
S
M
L
K
L
N
R
V
F
D
K
V
S
A
I
I
L
G
K
H
E
L
F
D
C
A
G
S
K
R
R
P
Y
E
V
L
T
E
V
L
D
G
K
Q
I
---
P
V
L
D
G
F
D
C
--
S
H
T
H
P
M
L
T
L
P
L
G
V
K
L
A
I
--------
21
HHSearch
85.89
24%
-89
- C5 -
3TLA
1
MCCF_ECOLX
A:
[39-359]
--------
P
L
A
V
G
D
T
I
G
F
F
S
--
S
S
A
P
-
A
T
V
T
A
K
N
R
F
F
R
-
G
V
E
F
L
Q
-
R
K
G
F
K
L
V
S
---
G
-
K
L
T
G
K
T
D
F
Y
R
S
G
T
I
K
E
R
A
Q
E
F
N
E
L
V
Y
N
P
D
I
T
C
I
M
S
T
I
G
G
D
N
S
N
S
L
L
P
F
L
D
Y
D
A
I
I
A
N
P
-
K
I
I
I
G
Y
S
D
T
T
A
L
L
A
G
I
Y
A
K
T
-----------
G
--------------
L
I
T
---------
F
Y
---------
G
---
P
A
L
I
P
S
F
G
---
E
--
H
P
P
L
V
D
I
--------------------------
T
Y
E
--
S
F
----
I
K
I
L
T
R
K
Q
S
G
I
Y
T
Y
T
L
P
EKWSDESINWNENKILRP
K
K
L
Y
K
--
N
N
C
--
A
F
-
Y
G
S
G
K
----------------------
V
E
------------
G
R
V
I
G
G
N
L
N
T
L
T
G
I
W
G
S
E
W
-
M
P
E
I
R
N
-
G
-
D
I
L
F
I
E
--
D
--
S
R
K
S
I
A
--
T
V
E
R
L
F
S
M
L
K
L
N
R
V
F
D
K
V
S
A
I
I
L
G
K
H
E
L
F
D
C
A
G
S
K
R
R
P
Y
E
V
L
T
E
V
L
D
G
K
Q
I
---
P
V
L
D
G
F
D
C
--
S
H
T
H
P
M
L
T
L
P
L
G
V
K
L
A
I
D
F
D
N
K
N
--
11
PsiBlast_PDB
85.11
24%
-90
- C5 -
3TLA
1
MCCF_ECOLX
A:
[40-353]
---------
L
A
V
G
D
T
I
G
F
F
S
--
S
S
A
P
-
A
T
V
T
A
K
N
R
F
F
R
G
V
E
F
L
Q
R
K
G
F
K
L
---
V
---
S
G
K
L
T
G
K
T
D
F
Y
R
S
G
T
I
K
E
R
A
Q
E
F
N
E
L
V
Y
N
P
D
I
T
C
I
M
S
T
I
G
G
D
N
S
N
S
L
L
P
F
L
D
Y
D
A
I
I
A
N
P
-
K
I
I
I
G
Y
S
D
T
T
A
L
L
A
G
I
Y
A
K
T
-----------
G
--------------
L
I
T
F--------
Y
G
---------
P
---
A
L
I
P
S
F
G
E
---
H
--
P
P
----
L
V
D
I
T
Y
E
S
F
I
K
I
L
TRKQS
G
I
Y
T
Y
T
L
P
E
K
W
S
--
D
E
----
S
I
N
W
N
E
N
K
------------------------------
I
L
--
R
P
K
K
-
L
Y
K
N
N
C
A
F
----------------------
Y
G
S
G
K
V
E
-------
G
R
V
I
G
G
N
L
N
T
L
T
G
I
W
G
S
E
W
-
M
P
E
I
-
R
-
N
G
D
I
L
F
I
E
--
D
--
S
R
K
S
I
A
--
T
V
E
R
L
F
S
M
L
K
L
N
R
V
F
D
K
V
S
A
I
I
L
G
K
H
E
L
F
D
C
A
G
S
K
R
R
P
Y
E
V
L
T
E
V
L
D
G
K
Q
I
---
P
V
L
D
G
F
D
C
--
S
H
T
H
P
M
L
T
L
P
L
G
V
K
L
A
I
--------
12
PsiBlast_PDB
84.64
24%
-88
- C5 -
3TLE
1
MCCF_ECOLX
A:
[40-353]
---------
L
A
V
G
D
T
I
G
F
F
S
--
S
S
A
P
-
A
T
V
T
A
K
N
R
F
F
R
G
V
E
F
L
Q
R
K
G
F
K
L
---
V
---
S
G
K
L
T
G
K
T
D
F
Y
R
S
G
T
I
K
E
R
A
Q
E
F
N
E
L
V
Y
N
P
D
I
T
C
I
M
S
T
I
G
G
D
N
S
N
S
L
L
P
F
L
D
Y
D
A
I
I
A
N
P
-
K
I
I
I
G
Y
S
D
T
T
A
L
L
A
G
I
Y
A
K
T
-----------
G
--------------
L
I
T
F--------
Y
G
---------
P
---
A
L
I
P
S
F
G
E
---
H
--
P
P
----
L
V
D
I
T
Y
E
S
F
I
K
I
L
TRKQS
G
I
Y
T
Y
T
L
PE
K
W
S
--
D
E
----
S
I
N
W
N
E
N
K
------------------------------
I
L
--
R
P
K
K
-
L
Y
K
N
N
C
A
F
----------------------
Y
G
S
G
K
V
E
-------
G
R
V
I
G
G
N
L
N
T
L
T
G
I
W
G
S
E
W
-
M
P
E
I
-
R
-
N
G
D
I
L
F
I
E
--
D
--
S
R
K
S
I
A
--
T
V
E
R
L
F
S
M
L
K
L
N
R
V
F
D
K
V
S
A
I
I
L
G
K
H
E
L
F
D
C
A
G
S
K
R
R
P
Y
E
V
L
T
E
V
L
D
G
K
Q
I
---
P
V
L
D
G
F
D
C
--
S
H
T
H
P
M
L
T
L
P
L
G
V
K
L
A
I
--------
13
PsiBlast_PDB
84.60
24%
-86
- C5 -
3TLB
1
MCCF_ECOLX
A:
[40-353]
---------
L
A
V
G
D
T
I
G
F
F
S
--
S
S
A
P
-
A
T
V
T
A
K
N
R
F
F
R
G
V
E
F
L
Q
R
K
G
F
K
L
---
V
---
S
G
K
L
T
G
K
T
D
F
Y
R
S
G
T
I
K
E
R
A
Q
E
F
N
E
L
V
Y
N
P
D
I
T
C
I
M
S
T
I
G
G
D
N
S
N
S
L
L
P
F
L
D
Y
D
A
I
I
A
N
P
-
K
I
I
I
G
Y
S
D
T
T
A
L
L
A
G
I
Y
A
K
T
-----------
G
--------------
L
I
T
F--------
Y
G
---------
P
---
A
L
I
P
S
F
G
E
---
H
--
P
P
----
L
V
D
I
T
Y
E
S
F
I
K
I
L
TRKQA
G
I
Y
T
Y
T
L
PE
K
W
S
--
D
E
----
S
I
N
W
N
E
N
K
------------------------------
I
L
--
R
P
K
K
-
L
Y
K
N
N
C
A
F
----------------------
Y
G
S
G
K
V
E
-------
G
R
V
I
G
G
N
L
N
T
L
T
G
I
W
G
S
E
W
-
M
P
E
I
-
R
-
N
G
D
I
L
F
I
E
--
D
--
S
R
K
S
I
A
--
T
V
E
R
L
F
S
M
L
K
L
N
R
V
F
D
K
V
S
A
I
I
L
G
K
H
E
L
F
D
C
A
G
S
K
R
R
P
Y
E
V
L
T
E
V
L
D
G
K
Q
I
---
P
V
L
D
G
F
D
C
--
S
H
T
H
P
M
L
T
L
P
L
G
V
K
L
A
I
--------
17
PsiBlast_PDB
84.15
23%
-88
- C5 -
4IIY
9
MCCF_ECOLX
A:
[40-353]
---------
L
A
V
G
D
T
I
G
F
F
S
--
S
S
A
P
-
A
T
V
T
A
K
N
R
F
F
R
G
V
E
F
L
Q
R
K
G
F
K
L
---
V
---
S
G
K
L
T
G
K
T
D
F
Y
R
S
G
T
I
K
E
R
A
Q
E
F
N
E
L
V
Y
N
P
D
I
T
C
I
M
S
T
I
G
G
D
N
S
N
S
L
L
P
F
L
D
Y
D
A
I
I
A
N
P
-
K
I
I
I
G
Y
A
D
T
T
A
L
L
A
G
I
Y
A
K
T
-----------
G
--------------
L
I
T
F--------
Y
G
---------
P
---
A
L
I
P
S
F
G
E
---
H
--
P
P
----
L
V
D
I
T
Y
E
S
F
I
K
I
L
T
RKQS
G
I
Y
T
Y
T
L
P
E
K
W
S
--
D
E
----
S
I
N
W
N
E
N
K
------------------------------
I
L
--
R
P
K
K
-
L
Y
K
N
N
C
A
F
----------------------
Y
G
S
G
K
V
E
-------
G
R
V
I
G
G
N
L
N
T
L
T
G
I
W
G
S
E
W
-
M
P
E
I
-
R
-
N
G
D
I
L
F
I
E
--
D
--
S
R
K
S
I
A
--
T
V
E
R
L
F
S
M
L
K
L
N
R
V
F
D
K
V
S
A
I
I
L
G
K
H
E
L
F
D
C
A
G
S
K
R
R
P
Y
E
V
L
T
E
V
L
D
G
K
Q
I
---
P
V
L
D
G
F
D
C
--
S
H
T
H
P
M
L
T
L
P
L
G
V
K
L
A
I
--------
16
PsiBlast_PDB
83.55
23%
-90
- C5 -
4IIX
7
MCCF_ECOLX
A:
[40-353]
---------
L
A
V
G
D
T
I
G
F
F
S
--
S
S
A
P
-
A
T
V
T
A
K
N
R
F
F
R
G
V
E
F
L
Q
R
K
G
F
K
L
---
V
---
S
G
K
L
T
G
K
T
D
F
Y
R
S
G
T
I
K
E
R
A
Q
E
F
N
E
L
V
Y
N
P
D
I
T
C
I
M
S
T
I
G
G
D
N
S
N
S
L
L
P
F
L
D
Y
D
A
I
I
A
N
P
-
K
I
I
I
G
Y
A
D
T
T
A
L
L
A
G
I
Y
A
K
T
-----------
G
--------------
L
I
T
F--------
Y
G
---------
P
---
A
L
I
P
S
F
G
E
---
H
--
P
P
----
L
V
D
I
T
Y
E
S
F
I
K
I
L
TRKQS
G
I
Y
T
Y
T
L
PE
K
W
S
--
D
E
----
S
I
N
W
N
E
N
K
------------------------------
I
L
--
R
P
K
K
-
L
Y
K
N
N
C
A
F
----------------------
Y
G
SGKVE-------
G
R
V
I
G
G
N
L
N
T
L
T
G
I
W
G
S
E
W
-
M
P
E
I
-
R
-
N
G
D
I
L
F
I
E
--
D
--
S
R
K
S
I
A
--
T
V
E
R
L
F
S
M
L
K
L
N
R
V
F
D
K
V
S
A
I
I
L
G
K
H
E
L
F
D
C
A
G
S
K
R
R
P
Y
E
V
L
T
E
V
L
D
G
K
Q
I
---
P
V
L
D
G
F
D
C
--
S
H
T
H
P
M
L
T
L
P
L
G
V
K
L
A
I
--------
20
PsiBlast_PDB
83.31
24%
-65
- C5 -
4H1H
2
?
A:
[9-300]
---------
L
K
Q
G
D
E
I
R
I
I
A
--
P
S
R
S
-
I
G
I
M
A
D
N
Q
V
E
I
-
A
V
N
R
L
-
T
D
M
G
F
K
V
T
F
---
G
E
H
V
-
A
E
M
D
C
M
M
S
S
S
I
R
S
R
V
A
D
I
H
E
A
F
N
D
S
S
V
K
A
I
L
T
V
I
G
G
F
N
S
N
Q
L
L
P
Y
L
D
Y
D
L
I
S
E
N
P
-
K
I
L
C
G
F
S
D
I
T
A
L
A
T
A
I
Y
T
Q
T
-----------
E
--------------
L
I
T
---------
Y
S
GAH
F
S
S
F
S
M
E
---
K
G
L
D
Y
V
M
E
S
F
S
D
--
C
L
----
L
--------------------------
Q
K
E
--
P
F
ALKE
S
A
T
W
S
D
D
E
------------------------------
W
Y
--
L
D
Q
E
-
N
R
-
N
F
I
P
N
----------------------
E
G
LVVM
Q
P
G
V
A
E
--
G
I
I
I
G
G
N
L
C
T
L
N
L
L
Q
G
T
E
Y
-
M
P
N
L
-
A
-
G
-
T
I
L
F
I
E
--
D
D
F
M
T
I
P
E
T
--
F
D
R
D
L
E
S
L
L
S
Q
P
G
A
-
D
E
I
E
G
M
V
I
G
R
F
Q
Q
-
K
T
A
M
T
A
E
K
L
A
Y
I
I
E
T
K
T
A
L
Q
K
I
---
P
V
I
S
G
A
D
F
--
G
H
T
----------------------
15
PsiBlast_PDB
83.28
23%
-87
- C5 -
3TLC
2
MCCF_ECOLX
A:
[40-353]
---------
L
A
V
G
D
T
I
G
F
F
S
--
S
S
A
P
-
A
T
V
T
A
K
N
R
F
F
R
G
V
E
F
L
Q
R
K
G
F
K
L
---
V
---
S
G
K
L
T
G
K
T
D
F
Y
R
S
G
T
I
K
E
R
A
Q
E
F
N
E
L
V
Y
N
P
D
I
T
C
I
M
S
T
I
G
G
D
N
S
N
S
L
L
P
F
L
D
Y
D
A
I
I
A
N
P
-
K
I
I
I
G
Y
A
D
T
T
A
L
L
A
G
I
Y
A
K
T
-----------
G
--------------
L
I
T
F--------
Y
G
---------
P
---
A
L
I
P
S
F
G
E
---
H
--
P
P
----
L
V
D
I
T
Y
E
S
F
I
K
I
L
TRKQS
G
I
Y
T
Y
T
L
P
E
K
W
S
--
D
E
----
S
I
N
W
N
E
N
K
------------------------------
I
L
--
R
P
K
K
-
L
Y
K
N
N
C
A
F
----------------------
Y
G
S
G
K
V
E
-------
G
R
V
I
G
G
N
L
N
T
L
T
G
I
W
G
S
E
W
-
M
P
E
I
-
R
-
N
G
D
I
L
F
I
E
--
D
--
S
R
K
S
I
A
--
T
V
E
R
L
F
S
M
L
K
L
N
R
V
F
D
K
V
S
A
I
I
L
G
K
H
E
L
F
D
C
A
G
S
K
R
R
P
Y
E
V
L
T
E
V
L
D
G
K
Q
I
---
P
V
L
D
G
F
D
C
--
S
H
T
H
P
M
L
T
L
P
L
G
V
K
L
A
I
--------
4
PsiBlast_PDB
83.06
24%
-72
- C5 -
4INJ
3
?
A:
[9-300]
---------
L
K
Q
G
D
E
I
R
I
I
A
--
P
S
R
S
-
I
G
I
M
A
D
N
Q
V
E
I
-
A
V
N
R
L
-
T
D
M
G
F
K
V
T
F
---
G
E
H
V
-
A
E
M
D
C
M
M
S
S
S
I
R
S
R
V
A
D
I
H
E
A
F
N
D
S
S
V
K
A
I
L
T
V
I
G
G
F
N
S
N
Q
L
L
P
Y
L
D
Y
D
L
I
S
E
N
P
-
K
I
L
C
G
F
A
D
I
T
A
L
A
T
A
I
Y
T
Q
T
-----------
E
LITYS
G
A
H
FSSFSM
E
K
G
---------
L
D
---------
Y
---
V
M
E
S
F
--
S
---
D
--
C
L
----
L
--------------------------
Q
K
E
--
P
F
ALKE
S
A
T
W
S
D
D
E
------------------------------
W
Y
--
L
D
Q
E
-
N
R
-
N
F
I
P
N
----------------------
E
G
LVVM
Q
P
G
V
A
E
--
G
I
I
I
G
G
N
L
C
T
L
N
L
L
Q
G
T
E
Y
-
M
P
N
L
-
A
-
G
-
T
I
L
F
I
E
--
D
D
F
M
T
I
P
E
T
--
F
D
R
D
L
E
S
L
L
S
Q
P
G
A
-
D
E
I
E
G
M
V
I
G
R
F
Q
Q
-
K
T
A
M
T
A
E
K
L
A
Y
I
I
E
T
K
T
A
L
Q
K
I
---
P
V
I
S
G
A
D
F
--
G
H
T
----------------------
42
Fugue
79.07
18%
-86
- C5 -
1ZL0
11
LDC_PSEAE
A:
[5-310]
SRPSS
D
Q
T
W
Q
P
I
D
G
R
V
A
L
I
A
--
P
A
S
A
I
A
T
D
V
L
E
A
T
L
R
Q
-
L
E
V
-----
H
G
V
D
Y
H
L
---
G
R
H
V
E
A
R
-
Y
R
Y
L
A
G
T
V
E
Q
R
L
E
D
L
H
N
A
F
D
M
P
D
I
T
A
V
W
C
L
R
G
G
Y
G
C
G
Q
L
L
P
G
L
D
W
G
R
L
Q
A
A
S
P
R
P
L
I
G
F
S
D
I
S
V
L
L
S
A
F
H
R
H
G
-----------
L
--------------
P
A
I
---------
H
G
---------
P
---
V
A
T
G
L
G
L
S
---
P
LS
A
P
----
R
--------------------------
E
Q
Q
--
E
R
----
L
A
S
L
A
S
V
S
------------------------------
R
L
--
L
A
G
I
-
D
H
-
E
L
P
V
Q
----------------------
H
L
G
GHK
Q
R
V
E
----
G
A
L
I
G
G
N
L
T
A
L
A
C
M
A
G
T
L
G
G
L
H
A
P
-
A
-
G
-
S
I
L
V
L
E
--
D
--
V
G
E
P
Y
Y
--
R
L
E
R
S
L
W
Q
L
L
E
S
I
D
A
R
Q
L
G
A
I
C
L
G
S
F
T
D
C
P
R
K
E
V
A
H
S
L
E
R
I
F
G
E
Y
A
A
A
I
E
V
---
P
L
Y
H
H
L
P
S
--
G
H
G
A
Q
N
R
A
W
P
Y
G
K
T
A
V
L
E
G
N
R
L
R
W
G
5
PsiBlast_PDB
78.97
26%
-78
- C5 -
3T5M
2
?
A:
[61-321]
---------------------------------------------------------------------
S
G
S
I
Q
E
R
A
K
E
L
N
A
L
I
R
N
P
N
V
S
C
I
M
S
T
I
G
G
M
N
S
N
S
L
L
P
Y
I
D
Y
D
A
F
Q
N
N
P
-
K
I
M
I
G
Y
A
D
A
T
A
L
L
L
G
I
Y
A
K
T
G
I
P
T
F
Y
G
P
A
LV
P
--------------
S
F
G
EFE
P
F
V
D
D
T
Y
K
---------
Y
F
L
E
T
L
L
H
D
Q
A
L
---
P
--
Y
N
----
I
--------------------------
K
Q
P
--
L
F
----
W
S
D
E
F
I
N
W
------------------------------
E
E
--
K
T
K
E
K
E
L
-
R
P
N
N
W
I
SV
T
N
G
Q
---------------
A
T
------------
G
R
V
I
G
G
N
L
N
T
I
Q
G
I
W
G
S
P
Y
-
M
P
C
I
-
Q
E
G
-
D
I
L
F
I
E
--
D
--
S
S
K
D
A
A
--
T
I
E
R
S
F
S
F
L
K
I
N
G
V
F
D
K
V
S
G
I
I
L
G
K
H
E
Q
F
D
D
C
G
T
N
R
K
P
Y
E
I
L
L
E
V
L
Q
N
Q
R
I
---
P
L
L
A
D
F
D
C
--
C
H
T
H
P
M
I
T
M
P
I
G
V
Q
V
K
M
--------
18
PsiBlast_PDB
78.60
25%
-73
- C5 -
4MI1
2
?
A:
[61-328]
---------------------------------------------------------------------
S
G
S
I
Q
E
R
A
K
E
L
N
A
L
I
R
N
P
N
V
S
C
I
M
S
T
I
G
G
M
N
S
N
S
L
L
P
Y
I
D
Y
D
A
F
Q
N
N
P
-
K
I
M
I
G
Y
A
D
A
T
A
L
L
L
G
I
Y
A
K
T
G
I
P
T
F
YGPALV
P
--------------
S
F
G
EFE
P
F
V
D
D
T
Y
K
---------
Y
F
L
E
T
L
L
H
D
Q
A
L
---
P
--
Y
N
----
I
--------------------------
K
Q
P
--
L
F
----
W
S
D
E
F
I
N
W
------------------------------
E
E
--
K
T
K
E
K
E
L
-
R
P
N
N
W
I
SV
T
N
G
Q
---------------
A
T
------------
G
R
V
I
G
G
N
L
N
T
I
Q
G
I
W
G
S
P
Y
-
M
P
C
I
-
Q
E
G
-
D
I
L
F
I
E
--
D
--
S
S
K
D
A
A
--
T
I
E
R
S
F
S
F
L
K
I
N
G
V
F
D
K
V
S
G
I
I
L
G
K
H
E
Q
F
D
D
C
G
T
N
R
K
P
Y
E
I
L
L
E
V
L
Q
N
Q
R
I
---
P
L
L
A
D
F
D
C
CA
T
H
P
M
I
T
M
P
I
G
V
Q
V
K
M
D
A
T
N
K
T
I
---
3
PsiBlast_PDB
78.45
26%
-78
- C5 -
3U1B
1
?
A:
[61-321]
---------------------------------------------------------------------
S
G
S
I
Q
E
R
A
K
E
L
N
A
L
I
R
N
P
N
V
S
C
I
M
S
T
I
G
G
M
N
S
N
S
L
L
P
Y
I
D
Y
D
A
F
Q
N
N
P
-
K
I
M
I
G
Y
S
D
A
T
A
L
L
L
G
I
Y
A
K
T
G
I
P
T
F
YGPALV
P
--------------
S
F
G
EFE
P
F
V
D
D
T
Y
K
---------
Y
F
L
E
T
L
L
H
D
Q
A
L
---
P
--
Y
N
----
I
--------------------------
K
Q
P
--
L
F
----
W
S
D
E
F
I
N
W
------------------------------
E
E
--
K
T
K
E
K
E
L
-
R
P
N
N
W
I
SV
T
N
G
Q
---------------
A
T
------------
G
R
V
I
G
G
N
L
N
T
I
Q
G
I
W
G
S
P
Y
-
M
P
C
I
-
Q
E
G
-
D
I
L
F
I
E
--
D
--
S
R
K
D
A
A
--
T
I
E
R
S
F
S
F
L
K
I
N
G
V
F
D
K
V
S
G
I
I
L
G
K
H
E
Q
F
D
D
C
G
T
N
R
K
P
Y
E
I
L
L
E
V
L
Q
N
Q
R
I
---
P
L
L
A
D
F
D
C
--
C
H
T
H
P
M
I
T
M
P
I
G
V
Q
V
K
M
--------
8
PsiBlast_PDB
78.32
25%
-71
- C5 -
4MJX
3
?
A:
[61-328]
---------------------------------------------------------------------
S
G
S
I
Q
E
R
A
K
E
L
N
A
L
I
R
N
P
N
V
S
C
I
M
S
T
I
G
G
M
N
S
N
S
L
L
P
Y
I
D
Y
D
A
F
Q
N
N
P
-
K
I
M
I
G
Y
A
D
A
T
A
L
L
L
G
I
Y
A
K
T
G
I
P
T
F
YGPALV
P
--------------
S
F
G
EFE
P
F
V
D
D
T
Y
K
---------
Y
F
L
E
T
L
L
H
D
Q
A
L
---
P
--
Y
N
----
I
--------------------------
K
Q
P
--
L
F
----
W
S
D
E
F
I
N
W
------------------------------
E
E
--
K
T
K
E
K
E
L
-
R
P
N
N
W
I
SV
T
N
G
Q
---------------
A
T
------------
G
R
V
I
G
G
N
L
N
T
I
Q
G
I
W
G
S
P
Y
-
M
P
C
I
-
Q
E
G
-
D
I
L
F
I
E
--
D
--
S
S
K
D
A
A
--
T
I
E
R
S
F
S
F
L
K
I
N
G
V
F
D
K
V
S
G
I
I
L
G
K
H
E
Q
F
D
D
C
G
T
N
R
K
P
Y
E
I
L
L
E
V
L
Q
N
Q
R
I
---
P
L
L
A
D
F
D
C
CA
T
H
P
M
I
T
M
P
I
G
V
Q
V
K
M
D
A
T
N
K
T
I
---
6
PsiBlast_PDB
78.19
25%
-83
- C5 -
3TYX
1
?
A:
[61-321]
---------------------------------------------------------------------
S
G
S
I
Q
E
R
A
K
E
L
N
A
L
I
R
N
P
N
V
S
C
I
M
S
T
I
G
G
M
N
S
N
S
L
L
P
Y
I
D
Y
D
A
F
Q
N
N
P
-
K
I
M
I
G
Y
S
D
A
T
A
L
L
L
G
I
Y
A
K
T
GIPTFYGPALV
P
--------------
S
F
G
EFE
P
F
V
D
D
T
Y
K
---------
Y
---
F
L
E
T
L
L
-
H
---
D
--
Q
A
----
L
--------------------------
P
Y
N
--
I
K
----
Q
P
L
F
W
S
D
E
------------------------------
S
I
--
N
W
E
E
-
K
T
-
K
E
K
E
L
----------------------
R
P
N
N
W
I
SV
T
N
G
Q
A
T
G
R
V
I
G
G
N
L
N
T
I
Q
G
I
W
G
S
P
Y
-
M
P
C
I
-
Q
E
G
-
D
I
L
F
I
E
--
D
--
S
S
K
D
A
A
--
T
I
E
R
S
F
S
F
L
K
I
N
G
V
F
D
K
V
S
G
I
I
L
G
K
H
E
Q
F
D
D
C
G
T
N
R
K
P
Y
E
I
L
L
E
V
L
Q
N
Q
R
I
---
P
L
L
A
D
F
D
C
--
C
H
T
H
P
M
I
T
M
P
I
G
V
Q
V
K
M
--------
7
PsiBlast_PDB
78.12
25%
-76
- C5 -
4JVO
1
?
A:
[61-328]
---------------------------------------------------------------------
S
G
S
I
Q
E
R
A
K
E
L
N
A
L
I
R
N
P
N
V
S
C
I
M
S
T
I
G
G
M
N
S
N
S
L
L
P
Y
I
D
Y
D
A
F
Q
N
N
P
-
K
I
M
I
G
Y
A
D
A
T
A
L
L
L
G
I
Y
A
K
T
G
I
P
T
F
YGPALV
P
--------------
S
F
G
EFE
P
F
V
D
D
T
Y
K
---------
Y
F
L
E
T
L
L
H
D
Q
A
L
---
P
--
Y
N
----
I
--------------------------
K
Q
P
--
L
F
----
W
S
D
E
F
I
N
W
------------------------------
E
E
--
K
T
K
E
K
E
L
-
R
P
N
N
W
I
SV
T
N
G
Q
---------------
A
T
------------
G
R
V
I
G
G
N
L
N
T
I
Q
G
I
W
G
S
P
Y
-
M
P
C
I
-
Q
E
G
-
D
I
L
F
I
E
--
D
--
S
S
K
D
A
A
--
T
I
E
R
S
F
S
F
L
K
I
N
G
V
F
D
K
V
S
G
I
I
L
G
K
H
E
Q
F
D
D
C
G
T
N
R
K
P
Y
E
I
L
L
E
V
L
Q
N
Q
R
I
---
P
L
L
A
D
F
D
C
CA
T
H
P
M
I
T
M
P
I
G
V
Q
V
K
M
D
A
T
N
K
T
I
---
2
PsiBlast_PDB
77.71
26%
-78
- C5 -
3SR3
-
?
A:
[58-318]
---------------------------------------------------------------------
S
G
S
I
Q
E
R
A
K
E
L
N
A
L
I
R
N
P
N
V
S
C
I
M
S
T
I
G
G
M
N
S
N
S
L
L
P
Y
I
D
Y
D
A
F
Q
N
N
P
-
K
I
M
I
G
Y
S
D
A
T
A
L
L
L
G
I
Y
A
K
T
G
I
P
T
F
YGPALV
P
--------------
S
F
G
EFEPF
V
D
D
T
Y
K
---------
Y
F
L
E
T
L
L
H
D
Q
A
L
---
P
--
Y
N
----
I
--------------------------
K
Q
P
--
L
F
----
W
S
D
E
F
I
N
A
------------------------------
E
E
--
K
T
K
E
K
E
L
-
R
P
N
N
W
I
SV
T
N
G
Q
---------------
A
T
------------
G
R
V
I
G
G
N
L
N
T
I
Q
G
I
W
G
S
P
Y
-
M
P
C
I
-
Q
E
G
-
D
I
L
F
I
E
--
D
--
S
S
K
D
A
A
--
T
I
E
R
S
F
S
F
L
K
I
N
G
V
F
D
K
V
S
G
I
I
L
G
K
H
E
Q
F
D
D
C
G
T
N
R
K
P
Y
E
I
L
L
E
V
L
Q
N
Q
R
I
---
P
L
L
A
D
F
D
C
--
C
H
T
H
P
M
I
T
M
P
I
G
V
Q
V
K
M
--------