@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo0032: (2016-03-11 )
LDIQESVIGIDLGGTKILIGEVTKDGEVLNSKSYPSNTENQTKATETLLKVLADYTQNIGFIAPKQTGIGVGLVGRVDHKSGVWLEIEPGKSNPTPLAGILEAKTGLPVSLGNDVVCATMAEKQFGWGRETNDFIYLNVGTGLAAGFVVDGRITQGGHFNAGEVGHAVVDIHSDVLCGCGRRGCVERLASGLGIKEEALRHLNSYPTSILAETQTELTGKMVLHAAEQKDELAEKIIDNATFQLANLIMNLVRTTDPECVILGGGVTRNEHFFQKIQDNLQSNTIRFVTKGVVRSKLEKDKVGLIGAAVIGMRLGNEGGKE
Atome Classification :
(20 SA)
----------------------------------------------------------------------.........10........20........30--...-.....40..-......50......-..60.....---...70........80..--------.-..----...---90---....--.-....100.......110.......120.......130.---.---.....140.......150.......160.......170-------..---------...---------...180.......190......--.200------.......-----210.----.....-...---220........230.......240.......250.......260......-.--270...-.....280....-.--..290-.......------.--300.......310.......320---
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----------------------------------------------------------------------LDIQE
S
V
I
G
I
DLGG
T
K
I
L
I
G
EVTKDG
E
V
LNS--KSY-PSNTENQ
T
K
-
A
T
E
T
L
L
K
V
L
A
D
Y
T
Q-NIGFIAPKQ---TGIGV
G
L
V
G
R
VDHKS
G
V
--------
W
-
L
E
----IEP---G----KSNP--T-
P
L
A
G
I
L
EAKTGL
P
V
SLGN
D
V
V
C
A
T
M
A
E
K
QFGWGRETN
D
---
F
---
I
Y
L
NVGTG
L
A
A
G
F
V
V
D
G
R
I
TQGGHF
N
A
G
EV
G
H
A
V
V
D
I--------H
S
---------
D
V
L
---------CGCG
R
R
G
C
V
E
R
L
A
SGLG
I
K
E
E
A
--
L
R
H
L
------NSY
P
T
S
I
-----
L
--
A
----
E
T
Q
T
E-LTG---
K
M
-
V
L
HA
A
E
Q
K
D
E
L
A
E
K
I
I
DN
A
T
F
Q
L
A
N
L
I
M
N
L
V
RTTDP
E
C
V
I
LGGGVTR-
N
--
E
H
-
F
F
Q
-
K
I
Q
D
N
LQSN
T
I
R
-
F
--
V
T
K
G
--
V
V
R
S
K
LE------K--DKV
G
L
I
G
A
A
V
I
G
M
R
LGNEGGKE----
22
HHSearch
90.84
28%
-90
- C1 -
2QM1
5
?
A:
[3-324]
-----------------------------------------------------------------------
A
M
D
K
K
I
I
G
I
D
L
G
G
T
T
I
K
F
A
I
L
T
T
D
G
V
V
Q
Q
K
--
W
S
I
-
E
T
N
I
L
E
D
G
K
H
I
V
P
S
I
I
E
S
I
R
H
R
I
D
-
L
Y
N
M
K
K
E
D
F
---
V
G
I
G
M
G
T
P
G
S
V
D
I
E
K
G
T
--------
V
V
G
A
----
Y
N
L
---
N
----
W
T
-
T
--
V
Q
P
V
K
E
Q
I
E
S
A
L
G
I
P
F
A
L
D
N
D
A
N
V
A
A
L
G
E
R
W
K
G
A
G
E
N
N
P
D
---
V
---
I
F
I
T
L
G
T
G
V
G
G
G
I
V
A
A
G
K
L
L
H
G
V
A
G
C
A
G
E
V
G
H
V
T
V
D
P
---------
N
---------
G
F
D
---------
C
T
C
G
K
R
G
C
L
E
T
V
S
S
A
T
G
V
V
R
V
A
--
R
H
L
S
------
E
E
F
A
G
D
S
-----
E
--
L
K
Q
A
I
D
D
G
Q
D
-
V
S
S
---
K
D
-
V
F
E
F
A
E
K
G
D
H
F
A
L
M
V
V
D
R
V
C
F
Y
L
G
L
A
T
G
N
L
G
N
T
L
N
P
D
S
V
V
I
G
G
G
V
S
A
-
A
--
G
E
F
L
R
S
-
R
V
E
K
Y
F
Q
E
F
T
F
P
Q
V
R
-
N
S
T
K
--
I
K
L
A
E
L
G
---------
N
E
A
G
V
I
G
A
A
S
L
A
L
Q
F
S
K
---------
24
HHSearch
89.51
29%
-91
- C1 -
3VOV
3
?
A:
[2-300]
---------------------------------------------------------------------------
K
V
V
G
L
D
L
G
G
T
K
I
A
A
G
V
F
D
G
-
K
R
L
L
S
K
--
V
V
V
-
P
T
P
K
E
-
G
G
E
R
V
A
E
A
L
A
E
A
A
E
R
A
E
R
-
E
---
A
G
V
R
G
---
E
A
I
G
L
G
T
P
G
P
L
D
F
R
R
G
V
--------
I
R-------
N
I
P--
G
----
V
Q
-
D
--
F
-
P
I
R
R
I
L
E
E
A
T
G
R
P
V
F
L
E
N
D
A
N
A
A
A
L
A
E
H
H
L
G
A
A
Q
G
E
E
S
---
S
---
L
Y
L
T
V
S
T
G
I
G
G
G
V
V
L
G
G
R
V
L
R
G
E
R
G
Q
G
G
E
L
G
H
L
T
L
L
P
---------
G
---------
G
P
A
---------
C
G
C
G
L
E
G
C
L
E
A
L
A
A
G
R
A
L
E
R
D
A
--
T
Y
A
F
------
Q
----------------------
R
P
-
V
D
T
---
R
E
-
L
F
R
L
F
Q
A
G
D
P
K
A
E
R
L
V
L
Q
A
A
R
Y
V
G
I
G
L
A
S
L
V
K
A
F
D
P
G
V
V
V
L
G
G
G
V
A
L
-
N
A-
P
E
G
Y
W
E
-
A
L
L
E
A
Y
R
R
Y
L
Q
G
-
W
--
E
A
P
P
--
L
R
R
A
R
L
G
---------
A
E
A
G
L
L
G
A
A
L
T
A
Y
L
E
V
K
D
G
-------
9
PsiBlast_PDB
89.21
28%
-96
- C1 -
3VGK
1
?
A:
[5-307]
-----------------------------------------------------------------------------
I
G
V
D
I
G
G
T
K
I
A
A
G
V
V
D
E
E
G
R
I
L
S
T
F
K
V
A
T
-
P
P
T
A
E
G
I
V
D
-
A
---
I
C
A
A
V
A
G
A
S
E
-
G
H
D
V
E
A
--------
V
G
I
G
A
A
G
Y
V
D
D
K
R
A
T
--------
V
-
L
F
----
A
P
N
---
I
----
D
W
R
H
--
E
-
P
L
K
D
K
V
E
Q
R
V
G
L
P
V
V
V
E
N
D
A
N
A
A
A
W
G
E
Y
R
F
G
A
G
Q
G
H
D
D
---
V
---
I
C
I
T
L
G
T
G
L
G
G
G
I
I
I
G
N
K
L
R
R
G
R
F
G
V
A
A
E
F
G
H
I
R
V
-
V
--------
P
D
---------
G
L
L
---------
C
G
C
G
S
Q
G
C
W
E
Q
Y
A
S
G
R
A
L
V
R
Y
A
--
K
Q
R
A
------
N
A
T
P
E
N
A
A
V
L
L
G
L
--
G
----
D
G
S
V
D
G
I
E
G
---
K
H
-
I
S
E
A
A
R
Q
G
D
P
V
A
V
D
S
F
R
E
L
A
R
W
A
G
A
G
L
A
D
L
A
S
L
F
D
P
S
A
F
I
V
G
G
G
V
S
D
-
E
--
G
E
-
L
----
V
L
D
P
I
R
K
S
F
R
R
-
W
--
L
I
G
G
--
E
W
R
P
H
A
Q
V
L
A
A
Q
L
G
--
G
K
A
G
L
V
G
A
A
-----------------
11
PsiBlast_PDB
88.78
28%
-95
- C1 -
3VGM
3
?
A:
[5-307]
-----------------------------------------------------------------------------
I
G
V
D
I
G
G
T
K
I
A
A
G
V
V
D
E
E
G
R
I
L
S
T
F
K
V
A
T
-
P
P
T
A
E
G
I
V
D
-
A
---
I
C
A
A
V
A
G
A
S
E
-
G
H
D
V
E
A
--------
V
G
I
G
A
A
G
Y
V
D
D
K
R
A
T
--------
V
-
L
F
----
A
P
N
---
I
----
D
W
R
H
--
E
-
P
L
K
D
K
V
E
Q
R
V
G
L
P
V
V
V
E
N
D
A
N
A
A
A
W
G
E
Y
R
F
G
A
G
Q
G
H
D
D
---
V
---
I
C
I
T
L
G
T
G
L
G
G
G
I
I
I
G
N
K
L
R
R
G
R
F
G
V
A
A
E
F
G
H
I
R
V
-
V
--------
P
D
---------
G
L
L
---------
C
G
C
G
S
Q
G
C
W
E
Q
Y
A
S
G
R
A
L
V
R
Y
A
--
K
Q
R
A
------
N
A
T
P
E
N
A
A
V
L
L
G
L
--
G
----
D
G
S
V
D
G
I
E
G
---
K
H
-
I
S
E
A
A
R
Q
G
D
P
V
A
V
D
S
F
R
E
L
A
R
W
A
G
A
G
L
A
D
L
A
S
L
F
D
P
S
A
F
I
V
G
G
G
V
S
D
-
E
--
G
E
-
L
----
V
L
D
P
I
R
K
S
F
R
R
-
W
--
L
I
G
G
--
E
W
R
P
H
A
Q
V
L
A
A
Q
L
G
--
G
K
A
G
L
V
G
A
A
-----------------
23
HHSearch
88.46
28%
-86
* C1 *
3VGL
4
?
A:
[2-313]
--------------------------------------------------------------------------
G
L
T
I
G
V
D
I
G
G
T
K
I
A
A
G
V
V
D
E
E
G
R
I
L
S
T
--
F
K
V
-
A
T
P
P
--
T
A
E
G
I
V
D
A
I
C
A
A
V
A
G
A
S
------
E
G
H
D
V
---
E
A
V
G
I
G
A
A
G
Y
V
D
D
K
R
A
T
--------
V
L
F
A
----
P
N
I
---
D
----
W
R
-
H
--
E
-
P
L
K
D
K
V
E
Q
R
V
G
L
P
V
V
V
E
N
D
A
N
A
A
A
W
G
E
Y
R
F
G
A
G
Q
G
H
D
D
---
V
---
I
C
I
T
L
G
T
G
L
G
G
G
I
I
I
G
N
K
L
R
R
G
R
F
G
V
A
A
E
F
G
H
I
R
V
V
P
---------
D
---------
G
L
L
---------
C
G
C
G
S
Q
G
C
W
E
Q
Y
A
S
G
R
A
L
V
R
Y
A
--
K
Q
R
A
------
N
A
T
P
E
N
A
A
V
---
L
L
G
L
G
D--
G
S
V
D
G
-
I
E
G
---
K
H
-
I
S
E
A
A
R
Q
G
D
P
V
A
V
D
S
F
R
E
L
A
R
W
A
G
A
G
L
A
D
L
A
S
L
F
D
P
S
A
F
I
V
G
G
G
V
S
D
-
E
--
G
E
L
V
L
D
-
P
I
R
K
S
F
R
R
W
L
I
G
G
E
W
R
P
H
A
Q
--
V
L
A
A
Q
L
G
---------
G
K
A
G
L
V
G
A
A
D
L
A
R
Q
G
-----------
10
PsiBlast_PDB
88.19
28%
-92
- C1 -
3VGL
4
?
A:
[5-307]
-----------------------------------------------------------------------------
I
G
V
D
I
G
G
T
K
I
A
A
G
V
V
D
E
E
G
R
I
L
S
T
F
K
V
A
T
-
P
P
T
A
E
G
I
V
D
-
A
---
I
C
A
A
V
A
G
A
S
E
-
G
H
D
V
E
A
--------
V
G
I
G
A
A
G
Y
V
D
D
K
R
A
T
--------
V
-
L
F
----
A
P
N
---
I
----
D
W
R
H
--
E
-
P
L
K
D
K
V
E
Q
R
V
G
L
P
V
V
V
E
N
D
A
N
A
A
A
W
G
E
Y
R
F
G
A
G
Q
G
H
D
D
---
V
---
I
C
I
T
L
G
T
G
L
G
G
G
I
I
I
G
N
K
L
R
R
G
R
F
G
V
A
A
E
F
G
H
I
R
V
-
V
--------
P
D
---------
G
L
L
---------
C
G
C
G
S
Q
G
C
W
E
Q
Y
A
S
G
R
A
L
V
R
Y
A
--
K
Q
R
A
------
N
A
T
P
E
N
A
A
V
L
L
G
L
--
G
----
D
G
S
V
D
G
I
E
G
---
K
H
-
I
S
E
A
A
R
Q
G
D
P
V
A
V
D
S
F
R
E
L
A
R
W
A
G
A
G
L
A
D
L
A
S
L
F
D
P
S
A
F
I
V
G
G
G
V
S
D
-
E
--
G
E
-
L
----
V
L
D
P
I
R
K
S
F
R
R
-
W
--
L
I
G
G
--
E
W
R
P
H
A
Q
V
L
A
AQL
G
--
G
K
A
G
L
V
G
A
A
-----------------
2
PsiBlast_PDB
88.13
27%
-92
- C1 -
1Z05
7
?
A:
[129-417]
-----------------------------------------------------------------------------------------------
G
E
V
L
I
D
--
T
K
I
-
D
I
H
E
I
D
Q
D
D
-
V
L
A
R
L
L
F
E
I
E
E
F
F
Q
-
T
Y
A
A
Q
L
D
R
V
---
T
S
I
A
I
T
L
P
G
L
V
N
S
E
Q
G
I
--------
V
-
L
Q
----
M
P
H
---
Y
----
N
V
K
N
--
L
-
A
L
G
P
E
I
Y
K
A
T
G
L
P
V
F
V
A
N
D
T
R
A
W
A
L
A
E
K
L
F
G
H
S
Q
D
V
D
N
---
S
---
V
L
I
S
I
H
H
G
L
G
A
G
I
V
L
D
G
R
V
L
Q
G
R
H
G
N
I
G
E
L
G
H
I
Q
I
D
P
--------
Q
G
---------
K
-
R
---------
C
H
C
G
N
Y
G
C
L
E
T
V
A
S
S
Q
A
I
R
D
Q
V
--
T
A
R
I
------
Q
A
G
E
P
S
C
-----
L
--
A
-----
T
V
E
E
-
I
S
I
---
E
D
-
I
C
A
A
A
A
D
G
D
P
L
A
V
D
V
I
Q
Q
L
G
R
Y
L
G
A
A
I
A
I
V
I
N
L
F
N
P
E
K
I
L
I
G
G
V
I
N
Q
-
A
--
K
S
I
L
Y
P
-
S
I
E
Q
C
I
R
E
Q
S
L
P
-
V
--
Y
H
Q
D
L
K
L
V
E
S
R
F
Y
------
K
---
Q
A
T
M
P
G
A
A
L
I
K
Q
A
L
-----------
14
PsiBlast_PDB
87.67
30%
-90
- C1 -
3VOV
3
?
A:
[3-291]
----------------------------------------------------------------------------
V
V
G
L
D
L
G
G
T
K
I
A
A
G
--
V
F
D
G
K
R
L
L
S
--
K
V
V
V
P
T
P
K
E
G
G
E
R
-
V
A
E
A
L
A
E
A
A
E
R
A
E
R
-
E
A
G
V
---
R
G
---
E
A
I
G
L
G
T
P
G
P
L
D
F
R
R
G
V
IR--------------
N
I
P
---
G
----
V
Q
D
---
F
-
P
I
R
R
I
L
E
E
A
T
G
R
P
V
F
L
E
N
D
A
N
A
A
A
L
A
E
H
H
L
G
A
A
Q
G
E
E
S
---
S
---
L
Y
L
T
V
S
T
G
I
G
G
G
V
V
L
G
G
R
V
L
R
G
E
R
G
Q
G
G
E
L
G
H
L
T
L
-
L
--------
P
G
---------
G
P
A
---------
C
G
C
G
L
E
G
C
L
E
A
L
A
A
G
R
A
L
E
R
D
A
--
T
Y
A
F
----------------------------
Q
R
P
-
V
D
T
---
R
E
-
L
F
R
L
F
Q
A
G
D
P
K
A
E
R
L
V
L
Q
A
A
R
Y
V
G
I
G
L
A
S
L
V
K
A
F
D
P
G
V
V
V
L
G
G
G
V
A
L
-
N
AP
E
G
-
Y
W
E
-
A
L
L
E
A
Y
R
R
Y
L
Q
G
-
W
--
E
A
P
P
--
L
R
R
A
R
L
G
------
A
--
E
-
A
G
L
L
G
A
A
L
----------------
46
Fugue
87.17
24%
-85
- C1 -
1Z05
8
?
A:
[34-429]
D
H
I
K
Q
I
N
A
G
R
V
Y
K
L
I
D
Q
KGPIS
R
I
D
L
S
K
E
S
ELA
P
A
S
I
T
K
I
T
R
E
L
I
D
A
HLIHETT
V
Q
E
A
I
S
R
G
R
P
A
V
G
L
QT
N
N
L
G
W
Q
F
L
S
M
R
L
G
R
G
Y
L
T
I
A
L
H
E
L
G
G
E
V
L
I
D
--
T
K
I
-
D
I
H
E
I
D
Q
D
D
-
V
L
A
R
L
L
F
E
I
E
E
F
F
Q
-
T
Y
A
A
Q
L
D
R
V
---
T
S
I
A
I
T
L
P
G
L
V
N
S
E
Q
G
I
--------
V
-
L
Q
----
M
P
H
---
Y
----
N
V
K
N
--
L
-
A
L
G
P
E
I
Y
K
A
T
G
L
P
V
F
V
A
N
D
T
R
A
W
A
L
A
E
K
L
F
G
H
S
Q
D
V
D
N
---
S
---
V
L
I
S
I
H
H
G
L
G
A
G
I
V
L
D
G
R
V
L
Q
G
R
H
G
N
I
G
E
L
G
H
I
Q
I
D
P
--------
Q
G
---------
K
-
R
---------
C
H
C
G
N
Y
G
C
L
E
T
V
A
S
S
Q
A
I
R
D
Q
V
--
T
A
R
I
------
Q
A
G
E
P
S
C
-----
L
--
A
----
T
V
E
-
E
-
I
S
I
---
E
D
-
I
C
A
A
A
A
D
G
D
P
L
A
V
D
V
I
Q
Q
L
G
R
Y
L
G
A
A
I
A
I
V
I
N
L
F
N
P
E
K
I
L
I
G
G
V
I
N
Q
A
K
--
S
I
-
L
Y
P
-
S
I
E
Q
C
I
R
E
Q
S
L
P
-
V
--
Y
H
Q
D
L
K
L
V
E
S
R
F
Y
------
K
--
Q
A
T
M
P
G
A
A
L
I
K
Q
A
L
Y
D
G
L
L
L
M
K
V
V
E
G
25
HHSearch
85.62
25%
-86
- C1 -
1Z05
7
?
A:
[106-417]
------------------------------------------------------------------------
L
G
W
Q
F
L
S
M
R
L
G
R
G
Y
L
T
I
A
L
H
E
L
G
G
E
V
L
I
D
--
T
K
I
-
D
I
H
E
I
-
D
Q
D
D
V
L
A
R
L
L
F
E
I
E
E
F
F
Q
-
T
Y
A
A
Q
L
D
R
V
---
T
S
I
A
I
T
L
P
G
L
V
N
S
E
Q
G
I
--------
V
L
Q
M
----
P
H
Y
---
N
----
V
K
-
N
--
L
-
A
L
G
P
E
I
Y
K
A
T
G
L
P
V
F
V
A
N
D
T
R
A
W
A
L
A
E
K
L
F
G
H
S
Q
D
V
D
N
---
S
---
V
L
I
S
I
H
H
G
L
G
A
G
I
V
L
D
G
R
V
L
Q
G
R
H
G
N
I
G
E
L
G
H
I
Q
I
D
P
---------
Q
---------
G
K
R
---------
C
H
C
G
N
Y
G
C
L
E
T
V
A
S
S
Q
A
I
R
D
Q
V
--
T
A
R
I
------
Q
A
G
E
P
S
C
--------
L
----
A
T
V
E
E
-
I
S
I
---
E
D
-
I
C
A
A
A
A
D
G
D
P
L
A
V
D
V
I
Q
Q
L
G
R
Y
L
G
A
A
I
A
I
V
I
N
L
F
N
P
E
K
I
L
I
G
G
V
I
N
Q
-
A
--
K
S
I
L
Y
P
-
S
I
E
Q
C
I
R
E
Q
S
L
P
-
V
YH
Q
D
L
K
--
L
V
E
S
R
F
Y
---------
K
Q
A
T
M
P
G
A
A
L
I
K
Q
A
L
-----------
1
PsiBlast_PDB
85.19
30%
-74
- C1 -
2QM1
5
?
A:
[6-324]
--------------------------------------------------------------------------
K
K
I
I
G
I
D
L
G
G
T
T
I
K
F
A
I
L
T
T
D
G
V
V
Q
Q
K
--
W
S
I
-
E
T
N
I
L
E
D
G
K
---
H
I
V
P
S
I
I
E
S
I
R
H
-
R
I
D
L
Y
N
M
K
K
EDF
V
G
I
G
M
G
T
P
G
S
V
D
I
E
K
G
T
VVGAYNLN
W
-
T
T
----
V
Q
P
---
V
----
K
E
Q
----------
I
E
S
A
L
G
I
P
F
A
L
D
N
D
A
N
V
A
A
L
G
E
R
W
K
G
A
G
E
N
N
P
D
---
V
---
I
F
I
T
L
G
T
G
V
G
G
G
I
V
A
A
G
K
L
L
H
G
V
A
G
C
A
G
E
V
G
H
V
T
V
D
P
--------
N
G
----------
F
D
---------
C
T
C
G
K
R
G
C
L
E
T
V
S
S
A
T
G
V
V
R
V
A
---
R
H
L
SEEFAG
D
S
E
L
K
Q
A
-----
I
--
D
----
D
G
Q
-
D
-
V
S
S
---
K
D
-
V
F
E
F
A
E
K
G
D
H
F
A
L
M
V
V
D
R
V
C
F
Y
L
G
L
A
T
G
N
L
G
N
T
L
N
P
D
S
V
V
I
G
G
G
V
S
A
-
A
--
G
E
-
F
L
R
S
R
V
E
K
Y
F
Q
E
F
T
F
P
-
Q
--
V
-
R
N
--
S
T
K
I
K
L
A
------
E
LG
N
E
A
G
V
I
G
A
A
S
L
A
L
Q
F
S
K
---------
8
PsiBlast_PDB
83.23
27%
-80
- C1 -
4HTL
1
BGLK_LISMO
A:
[6-285]
----------------------------------------------------------------------------
I
A
A
F
D
I
G
G
T
A
L
K
M
G
V
V
L
P
H
G
E
I
I
L
T
--
K
S
A
-
E
I
S
G
S
D
G
D
Q
-
I
L
A
E
M
K
V
F
L
A
E
N
T
D
---------
V
---
T
G
I
A
V
S
A
P
G
Y
V
N
P
K
T
G
L
----------------
I
T
M
---
G
GAIR
R
F
D
N
--
F
-
N
L
K
E
W
L
E
A
E
T
G
L
P
V
A
I
E
N
D
A
N
C
A
L
L
A
E
K
W
L
G
K
G
Q
D
L
D
D
---
F
---
L
C
L
T
I
G
T
G
I
G
G
G
I
F
S
N
G
E
L
V
R
G
G
R
F
R
A
G
E
F
G
Y
M
F
S
E
------------------------------------
R
P
G
A
F
R
P
G
K
Y
T
L
N
E
T
T
T
M
--
L
V
L
R
------
R
Q
Y
-
A
E
L
-----
T
--
G
----
R
P
L
E
E
-
I
T
G
---
E
E
-
I
F
A
N
Y
D
A
H
D
A
V
S
E
R
L
I
T
E
F
Y
T
G
I
C
T
G
L
Y
N
L
I
Y
L
F
D
P
T
H
I
F
I
G
G
G
I
T
S
-
R
--
P
T
-
F
I
A
-
E
L
K
H
H
M
E
S
F
G
L
R
------
D
T
--
I
I
E
T
A
T
H
------
K
--
N
Q
A
G
L
L
G
A
------------------
26
HHSearch
83.13
28%
-83
- C1 -
2AA4
1
NANK_ECOLI
A:
[1-288]
--------------------------------------------------------------------------
M
T
T
L
A
I
D
I
G
G
T
K
L
A
A
A
L
I
G
A
D
G
Q
I
R
D
R
--
R
E
L
-
P
T
P
A
S
Q
T
P
E
----
A
L
R
D
A
L
S
A
L
V
S
-
P
L
---
Q
A
H
A
---
Q
R
V
A
I
A
S
T
G
I
I
R
D
G
S
L
L
--------
A
L
N
P
----
H
N
L
---
G
G---
L
L
-
H
--
F
-
P
L
V
K
T
L
E
Q
L
T
N
L
P
T
I
A
I
N
D
A
Q
A
A
A
W
A
E
F
Q
A
L
D
-
G
D
I
T
D
---
M
---
V
F
I
T
V
S
T
G
V
G
G
G
V
V
S
G
C
K
L
L
T
G
P
G
G
L
A
G
H
I
G
H
T
L
A
D
P
---------
H
---------
G
P
V
---------
C
G
C
G
R
T
G
C
V
E
A
I
A
S
G
R
G
I
A
A
A
A
--
Q
G
E
L
------
A
-----------------------
G
-
A
D
A
---
K
T
-
I
F
T
R
A
G
Q
G
D
E
Q
A
Q
Q
L
I
H
R
S
A
R
T
L
A
R
L
I
A
D
I
K
A
T
T
D
C
Q
C
V
V
V
G
G
S
V
G
L
-
A
--
E
G
-
Y
L
A
-
L
V
E
T
Y
L
A
Q
E
P
A
--
A
--
F
H
V
D
--
L
L
A
A
H
Y
R
---------
H
D
A
G
L
L
G
A
A
L
L
A
Q
G
------------
29
HHSearch
82.36
24%
-86
- C1 -
2AP1
1
NAGK_SALTY
A:
[23-326]
-------------------------------------------------------------------------
N
A
M
Y
Y
G
F
D
I
G
G
T
K
I
A
L
G
V
F
D
S
T
R
R
L
Q
W
E
--
K
R
V
-
P
T
P
H
T
-
S
Y
S
A
F
L
D
A
V
C
E
L
V
E
E
A
D
Q
-
R
----
F
G
V
K
---
G
S
V
G
I
G
I
P
G
M
P
E
T
E
D
G
T
--------
L
Y
A
A
----
N
V
P
---
A
----
A
S
-
G
--
K
-
P
L
R
A
D
L
S
A
R
L
D
R
D
V
R
L
D
N
D
A
N
C
F
A
L
S
E
A
W
D
D
E
F
T
Q
Y
P
L
---
V
---
M
G
L
I
L
G
T
G
V
G
G
G
L
V
L
N
G
K
P
I
T
G
Q
S
Y
I
T
G
E
F
G
H
M
R
L
P
V
--------
D
A
L
T
L
M
GFDFP
L
R
R
---------
C
G
C
G
Q
M
G
C
I
E
N
Y
L
S
G
R
G
F
A
W
L
Y
--
Q
H
Y
Y
------
D
----------------------
Q
S
-
L
Q
A
---
P
E
-
I
I
A
L
W
E
Q
G
D
E
Q
A
H
A
H
V
E
R
Y
L
D
L
L
A
V
C
L
G
N
I
L
T
I
V
D
P
D
L
L
V
I
G
G
G
L
S
N
-
F
--
T
A
-
I
T
T
-
Q
L
A
E
R
L
P
R
H
L
L
P
-
V
A-
R
A
P
R
--
I
E
R
A
R
H
G
---------
D
A
G
G
M
R
G
A
A
F
L
H
L
T
------------
17
PsiBlast_PDB
81.78
23%
-89
- C1 -
2AP1
1
NAGK_SALTY
A:
[28-325]
------------------------------------------------------------------------------
G
F
D
I
G
G
T
K
I
A
L
G
V
F
D
S
T
R
R
L
Q
W
E
--
K
R
V
-
P
T
P
H
T
S
Y
S
A
-
F
L
D
A
V
C
E
L
V
E
E
A
D
Q
-
R
F
G
V
----
K
---
G
S
V
G
I
G
I
P
G
M
P
E
T
E
D
G
T
--------
L
-
Y
A
----
A
N
V
---
P
----
A
A
S
G
--
K
-
P
L
R
A
D
L
S
A
R
L
D
R
D
V
R
L
D
N
D
A
N
C
F
A
L
S
E
---
A
W
D
D
E
F
T
Q
---
Y
P
L
V
M
G
L
I
L
G
T
G
V
G
G
G
L
V
L
N
G
K
P
I
T
G
Q
S
Y
I
T
G
E
F
G
H
M
R
L
P
V
--------
D
A
---------
L
T
L
M
GFDFPLRR
C
G
C
G
Q
M
G
C
I
E
N
Y
L
S
G
R
G
F
---
A
--
W
L
Y
Q
------
H
Y
Y
D
Q
S
L
-----
Q
--
A
----
P
E
-------------
I
I
A
L
W
E
Q
G
D
E
Q
A
H
A
H
V
E
R
Y
L
D
L
L
A
V
C
L
G
N
I
L
T
I
V
D
P
D
L
L
V
I
G
G
G
L
S
N
-
F
--
T
A
-
I
T
T
-
Q
L
A
E
R
L
P
R
H
L
L
P
-
V
--
A
R
A
P
--
R
I
E
R
A
R
H
------
G
--
D
A
G
G
M
R
G
A
A
F
L
H
L
-------------
3
PsiBlast_PDB
81.52
31%
-80
- C1 -
2AA4
1
NANK_ECOLI
A:
[2-264]
---------------------------------------------------------------------------
T
T
L
A
I
D
I
G
G
T
K
L
A
A
A
L
I
G
A
D
G
Q
I
R
D
R
--
R
E
L
-
P
T
P
A
S
Q
T
P
E
-
A
L
R
D
A
L
S
A
L
V
S
P
L
Q
A
H
A
Q
R
V
A
I
A
S
---
T
G
I
---------
I
R
D
G
S
--------
L
-
L
A
----
L
N
P
HNL
G
----
G
L
L
H
--
F
-
P
L
V
K
T
L
E
Q
L
T
N
L
P
T
I
A
I
N
D
A
Q
A
A
A
W
A
E
F
Q
A
L
D
G
-
D
I
T
D
---
M
---
V
F
I
T
V
S
T
G
V
G
G
G
V
V
S
G
C
K
L
L
T
G
P
G
G
L
A
G
H
I
G
H
T
L
A
D
P
--------
H
G
---------
P
V
----------
C
G
C
G
R
T
G
C
V
E
A
I
A
S
G
R
G
I
A
------------------------------
A
----
A
A
Q
G
E
-
L
A
G
AD
A
K
T
-
I
F
T
R
A
G
Q
G
D
E
Q
A
Q
Q
L
I
H
R
S
A
R
T
L
A
R
L
I
A
D
I
K
A
T
T
D
C
Q
C
V
V
V
G
G
S
V
G
L
-
A
--
E
G
-
Y
L
A
-
L
V
E
T
Y
L
A
Q
E
P
A
A
-
F
--------------------------------------------------
21
PsiBlast_CBE
80.66
31%
-79
- C1 -
2AA4
1
NANK_ECOLI
B:
[2-264]
---------------------------------------------------------------------------
T
T
L
A
I
D
I
G
G
T
K
L
A
A
A
L
I
G
A
D
G
Q
I
R
D
R
--
R
E
L
-
P
T
P
A
S
Q
T
P
E
-
A
L
R
D
A
L
S
A
L
V
S
P
L
Q
A
H
A
Q
R
V
A
I
A
S
---
T
G
I
---------
I
R
D
G
S
--------
L
-
L
A
----
L
N
P
HNL
G
----
G
L
L
H
--
F
-
P
L
V
K
T
L
E
Q
L
T
N
L
P
T
I
A
I
N
D
A
Q
A
A
A
W
A
E
F
Q
A
L
D
G
-
D
I
T
D
---
M
---
V
F
I
T
V
S
T
G
V
G
G
G
V
V
S
G
C
K
L
L
T
G
P
G
G
L
A
G
H
I
G
H
T
L
A
D
P
--------
H
G
---------
P
V
----------
C
G
C
G
R
T
G
C
V
E
A
I
A
S
G
R
G
I
A
------------------------------
A
----
A
A
Q
G
E
-
L
A
G
ADA
K
T
-
I
F
T
R
A
G
Q
G
D
E
Q
A
Q
Q
L
I
H
R
S
A
R
T
L
A
R
L
I
A
D
I
K
A
T
T
D
C
Q
C
V
V
V
G
G
S
V
G
L
-
A
--
E
G
-
Y
L
A
-
L
V
E
T
Y
L
A
Q
E
P
A
A
-
F
--------------------------------------------------
7
PsiBlast_PDB
80.61
27%
-91
- C1 -
2YI1
12
A:
[31-311]
---------------------------------------------------------------------------
S
A
L
A
V
D
L
G
G
T
N
L
R
V
A
I
V
S
M
K
G
E
I
V
K
---
K
Y
T
-
Q
F
N
P
K
T
Y
E
E
-
R
I
N
L
I
L
Q
M
C
V
E
A
A
A
-
E
A
V
K
L
N
C
R
I
---
L
G
V
G
I
S
T
G
G
R
V
N
P
R
E
G
I
--------
V
-
L
H
STKL
I
Q
E
---
W
----
N
S
V
D
L
R
T
-
P
L
S
D
T
L
H
----
L
P
V
W
V
D
N
D
G
N
C
A
A
L
A
E
R
K
F
G
Q
G
K
G
L
E
N
---
F
---
V
T
L
I
T
G
T
G
I
G
G
G
I
I
H
Q
H
E
L
I
H
G
S
S
F
C
A
A
E
L
G
H
L
V
V
S
L
--------
D
G
---------
P
D
----------
C
S
C
G
S
H
G
C
I
E
A
Y
A
S
G
M
A
L
Q
R
E
A
K
K
L
H
D
E
------
D
L
L
L
V
E
G
-----
M
--
S
----------
A
V
G
---
A
L
H
L
I
Q
A
A
K
L
G
N
A
K
A
Q
S
I
L
R
T
A
G
T
A
L
G
L
G
V
V
N
I
L
H
T
M
N
P
S
L
V
I
L
S
G
V
L
A
-----
S
H
-
Y
I
H
-
I
V
K
D
V
I
R
Q
Q
A
L
-----------------------------------------------------
6
PsiBlast_PDB
80.18
27%
-92
- C1 -
2YHY
13
A:
[31-311]
---------------------------------------------------------------------------
S
A
L
A
V
D
L
G
G
T
N
L
R
V
A
I
V
S
M
K
G
E
I
V
K
---
K
Y
T
-
Q
F
N
P
K
T
Y
E
E
-
R
I
N
L
I
L
Q
M
C
V
E
A
A
A
-
E
A
V
K
L
N
C
R
I
---
L
G
V
G
I
S
T
G
G
R
V
N
P
R
E
G
I
--------
V
-
L
H
STKL
I
Q
E
---
W
----
N
S
V
D
L
R
T
-
P
L
S
D
T
L
H
----
L
P
V
W
V
D
N
D
G
N
C
A
A
L
A
E
R
K
F
G
Q
G
K
G
L
E
N
---
F
---
V
T
L
I
T
G
T
G
I
G
G
G
I
I
H
Q
H
E
L
I
H
G
S
S
F
C
A
A
E
L
G
H
L
V
V
S
L
--------
D
G
---------
P
D
----------
C
S
C
G
S
H
G
C
I
E
A
Y
A
S
G
M
A
L
Q
R
E
A
K
K
L
H
D
E
------
D
L
L
L
V
E
G
-----
M
--
S
----------
A
V
G
---
A
L
H
L
I
Q
A
A
K
L
G
N
A
K
A
Q
S
I
L
R
T
A
G
T
A
L
G
L
G
V
V
N
I
L
H
T
M
N
P
S
L
V
I
L
S
G
V
L
A
-----
S
H
-
Y
I
H
-
I
V
K
D
V
I
R
Q
Q
A
L
-----------------------------------------------------
4
PsiBlast_PDB
80.07
26%
-76
- C1 -
4DB3
5
NAGK_VIBVU
A:
[28-326]
------------------------------------------------------------------------------
G
F
D
V
G
G
T
K
I
E
F
G
A
F
N
E
K
L
E
R
V
A
T
--
E
R
V
-
P
T
P
T
D
D
Y
P
L
-
L
L
E
T
I
A
G
L
V
A
K
Y
D
Q
-
E
F
A
C
----
E
---
G
K
I
G
L
G
L
P
G
M
E
D
A
D
D
A
T
--------
V
-
L
T
----
V
N
V
---
P
----
A
A
K
G
--
K
-
P
L
R
A
D
L
E
A
K
I
G
R
S
V
K
I
E
N
D
A
N
C
F
A
L
S
E
---
A
W
D
E
E
L
Q
D
AP
S
V
---
M
G
L
I
L
G
T
G
F
G
G
G
L
I
Y
E
G
K
V
F
S
G
R
N
N
V
A
G
E
L
G
H
M
R
L
P
L
D
A
W
F
H
L
GD
N
A
---------
P
L
L
G--------
C
G
C
G
K
K
G
C
L
D
S
Y
L
S
G
R
G
F
E
-----
L
L
Y
A
------
H
Y
Y
------------
G
----
E
E
K
K
A
-
I
D
-------
I
I
K
A
N
A
A
G
D
E
K
A
A
E
H
V
E
R
F
M
E
L
L
A
I
C
F
G
N
I
F
T
A
N
D
P
H
V
V
A
L
G
G
G
L
S
N
-
F
--
E
L
-
I
Y
E
-
E
M
P
K
R
V
P
K
Y
L
L
S
-
V
--
A
K
C
P
--
K
I
I
K
A
K
H
------
G
--
D
S
G
G
V
R
G
A
A
F
L
N
I
K
------------